Harvard Catalyst Profiles

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Roger Joseph Laham, M.D.

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Mentoring

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. P50HL063609 (AIRD, WILLIAM C) Apr 1, 2000 - Mar 31, 2005
    NIH/NHLBI
    ENDOTHELIAL CELL SIGNALING AND CARDIAC ANGIOGENESIS
    Role: Co-Principal Investigator
  2. M01RR001032 (SUKHATME, VIKAS P) Dec 1, 1977 - Mar 31, 2010
    NIH/NCRR
    General Clinical Research Center
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Shi SM, Sung M, Afilalo J, Lipsitz LA, Kim CA, Popma JJ, Khabbaz KR, Laham RJ, Guibone K, Lee J, Marcantonio ER, Kim DH. Delirium Incidence and Functional Outcomes After Transcatheter and Surgical Aortic Valve Replacement. J Am Geriatr Soc. 2019 Mar 18. PMID: 30882905.
    Citations:    
  2. Kim DH, Afilalo J, Shi SM, Popma JJ, Khabbaz KR, Laham RJ, Grodstein F, Guibone K, Lux E, Lipsitz LA. Evaluation of Changes in Functional Status in the Year After Aortic Valve Replacement. JAMA Intern Med. 2019 Feb 04. PMID: 30715097.
    Citations:    
  3. Song YB, Arbab-Zadeh A, Matheson MB, Ostovaneh MR, Vavere AL, Dewey M, Rochitte C, Niinuma H, Laham R, Schuijf JD, Cox C, Brinker J, di Carli M, Lima JAC, Miller JM. Contemporary Discrepancies of Stenosis Assessment by Computed Tomography and Invasive Coronary Angiography. Circ Cardiovasc Imaging. 2019 Feb; 12(2):e007720. PMID: 30764641.
    Citations:    
  4. Kundi H, Popma JJ, Cohen DJ, Liu DC, Laham RJ, Pinto DS, Chu LM, Strom JB, Shen C, Yeh RW. Prevalence and Outcomes of Isolated Tricuspid Valve Surgery Among Medicare Beneficiaries. Am J Cardiol. 2019 Jan 01; 123(1):132-138. PMID: 30442362.
    Citations:    Fields:    
  5. Shi S, Afilalo J, Lipsitz LA, Popma JJ, Khabbaz KR, Laham RJ, Guibone K, Grodstein F, Lux E, Kim DH. Frailty Phenotype and Deficit Accumulation Frailty Index in Predicting Recovery After Transcatheter and Surgical Aortic Valve Replacement. J Gerontol A Biol Sci Med Sci. 2018 Aug 25. PMID: 30165422.
    Citations:    Fields:    
  6. Ravindran K, DiStasio M, Laham R, Ogilvy CS, Thomas AJ, VanderLaan PA, Alturki AY. Histopathological Demonstration of Subacute Endothelialization Following Aneurysm Retreatment with the Pipeline Embolization Device. World Neurosurg. 2018 Oct; 118:156-160. PMID: 30031197.
    Citations:    Fields:    Translation:Humans
  7. Buitrago DH, Pinto D, Berkowitz SJ, Laham RJ, Hecht JL, Kent MS. Fatal Hemoptysis After Closure of Gastrobronchial Fistula Using an Amplatzer Vascular Device. Ann Thorac Surg. 2018 Feb; 105(2):e71-e73. PMID: 29362196.
    Citations:    Fields:    Translation:Humans
  8. Khamooshian A, Jeganthan J, Amador Y, Laham RJ, Mahmood F, Matyal R. Mechanical discordance between left atrium and left atrial appendage. Ann Card Anaesth. 2018 Jan-Mar; 21(1):82-84. PMID: 29336402.
    Citations:    Fields:    Translation:Humans
  9. Chen MY, Rochitte CE, Arbab-Zadeh A, Dewey M, George RT, Miller JM, Niinuma H, Yoshioka K, Kitagawa K, Sakuma H, Laham R, Vavere AL, Cerci RJ, Mehra VC, Nomura C, Kofoed KF, Jinzaki M, Kuribayashi S, Scholte AJ, Laule M, Tan SY, Hoe J, Paul N, Rybicki FJ, Brinker JA, Arai AE, Matheson MB, Cox C, Clouse ME, Di Carli MF, Lima JAC. Prognostic Value of Combined CT Angiography and Myocardial Perfusion Imaging versus Invasive Coronary Angiography and Nuclear Stress Perfusion Imaging in the Prediction of Major Adverse Cardiovascular Events: The CORE320 Multicenter Study. Radiology. 2017 07; 284(1):55-65. PMID: 28290782.
    Citations: 3     Fields:    Translation:Humans
  10. Feng G, Xiao J, Bi Y, Lan Z, Zheng X, Lu Z, Li J, Wu K, Kislauskis E, McCarthy S, Hu Q, Jiang X, Wu T, Laham R. 12-Month Coronary Angiography, Intravascular Ultrasound and Histology Evaluation of a Novel Fully Bioabsorbable Poly-L-Lactic Acid/Amorphous Calcium Phosphate Scaffolds in Porcine Coronary Arteries. J Biomed Nanotechnol. 2016 Apr; 12(4):743-52. PMID: 27301200.
    Citations: 1     Fields:    Translation:Animals
  11. Feng R, Saraf R, Shapeton A, Matyal R, Laham R, Mahmood F. A Complex Atrial Septal Defect and Three-Dimensional Echocardiography: A Question and an Answer. J Cardiothorac Vasc Anesth. 2016 Aug; 30(4):1050-2. PMID: 26746796.
    Citations: 1     Fields:    Translation:Humans
  12. Xiao J, Feng G, Kang G, Lan Z, Liao T, Kislauskis E, Chen J, Xia J, Wang Z, Huo Z, Wang Q, Xi T, McCarthy S, Jiang X, Wu T, Laham R. 6-Month Follow-Up of a Novel Biodegradable Drug-Eluting Stent Composed of Poly-L-Lactic Acid and Amorphous Calcium Phosphate Nanoparticles in Porcine Coronary Artery. J Biomed Nanotechnol. 2015 Oct; 11(10):1819-25. PMID: 26502644.
    Citations: 1     Fields:    Translation:Animals
  13. Kishi S, Magalhaes TA, George RT, Dewey M, Laham RJ, Niinuma H, Friedman LA, Cox C, Tanami Y, Schuijf JD, Vavere AL, Kitagawa K, Chen MY, Nomura CH, Brinker JA, Rybicki FJ, Di Carli MF, Arbab-Zadeh A, Lima JA. Relationship of left ventricular mass to coronary atherosclerosis and myocardial ischaemia: the CORE320 multicenter study. Eur Heart J Cardiovasc Imaging. 2015 Feb; 16(2):166-76. PMID: 25368207.
    Citations: 1     Fields:    Translation:Humans
  14. Lan Z, Lyu Y, Xiao J, Zheng X, He S, Feng G, Zhang Y, Wang S, Kislauskis E, Chen J, McCarthy S, Laham R, Jiang X, Wu T. Novel biodegradable drug-eluting stent composed of poly-L-lactic acid and amorphous calcium phosphate nanoparticles demonstrates improved structural and functional performance for coronary artery disease. J Biomed Nanotechnol. 2014 Jul; 10(7):1194-204. PMID: 24804540.
    Citations: 2     Fields:    Translation:Animals
  15. Zheng X, Wang Y, Lan Z, Lyu Y, Feng G, Zhang Y, Tagusari S, Kislauskis E, Robich MP, McCarthy S, Sellke FW, Laham R, Jiang X, Gu WW, Wu T. Improved biocompatibility of poly(lactic-co-glycolic acid) orv and poly-L-lactic acid blended with nanoparticulate amorphous calcium phosphate in vascular stent applications. J Biomed Nanotechnol. 2014 Jun; 10(6):900-10. PMID: 24749387.
    Citations: 1     Fields:    Translation:Animals
  16. Rochitte CE, George RT, Chen MY, Arbab-Zadeh A, Dewey M, Miller JM, Niinuma H, Yoshioka K, Kitagawa K, Nakamori S, Laham R, Vavere AL, Cerci RJ, Mehra VC, Nomura C, Kofoed KF, Jinzaki M, Kuribayashi S, de Roos A, Laule M, Tan SY, Hoe J, Paul N, Rybicki FJ, Brinker JA, Arai AE, Cox C, Clouse ME, Di Carli MF, Lima JA. Computed tomography angiography and perfusion to assess coronary artery stenosis causing perfusion defects by single photon emission computed tomography: the CORE320 study. Eur Heart J. 2014 May; 35(17):1120-30. PMID: 24255127.
    Citations: 87     Fields:    Translation:Humans
  17. Lassaletta AD, Elmadhun NY, Liu Y, Feng J, Burgess TA, Karlson NW, Laham RJ, Sellke FW. Ethanol promotes arteriogenesis and restores perfusion to chronically ischemic myocardium. Circulation. 2013 Sep 10; 128(11 Suppl 1):S136-43. PMID: 24030397.
    Citations: 5     Fields:    Translation:Animals
  18. Melman YF, Levy MS, Laham RJ. Intracardiac echocardiography and fluoroscopy guided percutaneous left ventricular pseudoaneurysm closure. Catheter Cardiovasc Interv. 2013 Dec 01; 82(7):E915-8. PMID: 21954145.
    Citations:    Fields:    Translation:Humans
  19. Cerci R, Vavere AL, Miller JM, Yoneyama K, Rochitte CE, Dewey M, Niinuma H, Clouse ME, Laham R, Bush DE, Shapiro EP, Lardo AC, Cox C, Brinker J, Lima JA, Arbab-Zadeh A. Patterns of coronary arterial lesion calcification by a novel, cross-sectional CT angiographic assessment. Int J Cardiovasc Imaging. 2013 Oct; 29(7):1619-27. PMID: 23702949.
    Citations: 3     Fields:    Translation:Humans
  20. Chu LM, Lassaletta AD, Robich MP, Liu Y, Burgess T, Laham RJ, Sweeney JD, Shen TL, Sellke FW. Effects of red wine and vodka on collateral-dependent perfusion and cardiovascular function in hypercholesterolemic swine. Circulation. 2012 Sep 11; 126(11 Suppl 1):S65-72. PMID: 22965995.
    Citations: 12     Fields:    Translation:Animals
  21. Robich MP, Chu LM, Burgess TA, Feng J, Han Y, Nezafat R, Leber MP, Laham RJ, Manning WJ, Sellke FW. Resveratrol preserves myocardial function and perfusion in remote nonischemic myocardium in a swine model of metabolic syndrome. J Am Coll Surg. 2012 Nov; 215(5):681-9. PMID: 22867714.
    Citations: 11     Fields:    Translation:Animals
  22. Touchan J, Levy MS, Laham RJ. Percutaneous retrieval of fractured Bird's Nest IVC filter penetrating into aorta. Catheter Cardiovasc Interv. 2012 Oct 01; 80(4):657-60. PMID: 22488685.
    Citations: 1     Fields:    Translation:Humans
  23. Lassaletta AD, Chu LM, Robich MP, Elmadhun NY, Feng J, Burgess TA, Laham RJ, Sturek M, Sellke FW. Overfed Ossabaw swine with early stage metabolic syndrome have normal coronary collateral development in response to chronic ischemia. Basic Res Cardiol. 2012 Mar; 107(2):243. PMID: 22231675.
    Citations: 24     Fields:    Translation:Animals
  24. Vavere AL, Simon GG, George RT, Rochitte CE, Arai AE, Miller JM, Di Carli M, Arbab-Zadeh A, Zadeh AA, Dewey M, Niinuma H, Laham R, Rybicki FJ, Schuijf JD, Paul N, Hoe J, Kuribyashi S, Sakuma H, Nomura C, Yaw TS, Kofoed KF, Yoshioka K, Clouse ME, Brinker J, Cox C, Lima JA. Diagnostic performance of combined noninvasive coronary angiography and myocardial perfusion imaging using 320 row detector computed tomography: design and implementation of the CORE320 multicenter, multinational diagnostic study. J Cardiovasc Comput Tomogr. 2011 Nov-Dec; 5(6):370-81. PMID: 22146496.
    Citations: 24     Fields:    Translation:HumansCTClinical Trials
  25. Chu LM, Robich MP, Lassaletta AD, Feng J, Laham RJ, Burgess T, Clements RT, Sellke FW. Resveratrol supplementation abrogates pro-arteriogenic effects of intramyocardial vascular endothelial growth factor in a hypercholesterolemic swine model of chronic ischemia. Surgery. 2011 Sep; 150(3):390-9. PMID: 21783219.
    Citations: 3     Fields:    Translation:AnimalsCells
  26. Levy MS, Laham RJ. Virtual histologic guidance of percutaneous peripheral atherectomy: the evolution of a new paradigm? J Invasive Cardiol. 2011 Jul; 23(7):274-5. PMID: 21725121.
    Citations:    Fields:    Translation:Humans
  27. Pervaiz MH, Laham RJ. Distal anchoring technique: yet another weapon for successful intervention. J Invasive Cardiol. 2011 Jul; 23(7):295-6. PMID: 21725126.
    Citations:    Fields:    Translation:Humans
  28. Dejam A, Hokinson M, Laham R. Repeated successful balloon valvuloplasty of a bioprosthetic aortic valve in a nonagenerian. Catheter Cardiovasc Interv. 2011 Mar 01; 77(4):589-92. PMID: 21351233.
    Citations: 1     Fields:    Translation:Humans
  29. Ma X, Oyamada S, Wu T, Robich MP, Wu H, Wang X, Buchholz B, McCarthy S, Bianchi CF, Sellke FW, Laham R. In vitro and in vivo degradation of poly(D, L-lactide-co-glycolide)/amorphous calcium phosphate copolymer coated on metal stents. J Biomed Mater Res A. 2011 Mar 15; 96(4):632-8. PMID: 21268237.
    Citations: 2     Fields:    Translation:Animals
  30. Wykrzykowska JJ, Rosinberg A, Lee SU, Voisine P, Wu G, Appelbaum E, Boodhwani M, Sellke FW, Laham RJ. Autologous cardiomyotissue implantation promotes myocardial regeneration, decreases infarct size, and improves left ventricular function. Circulation. 2011 Jan 04; 123(1):62-9. PMID: 21173354.
    Citations: 2     Fields:    Translation:Animals
  31. Oyamada S, Ma X, Wu T, Robich MP, Wu H, Wang X, Buchholz B, McCarthy S, Bianchi CF, Sellke FW, Laham R. Trans-iliac rat aorta stenting: a novel high throughput preclinical stent model for restenosis and thrombosis. J Surg Res. 2011 Mar; 166(1):e91-5. PMID: 21195423.
    Citations: 4     Fields:    Translation:Animals
  32. Ma X, Oyamada S, Gao F, Wu T, Robich MP, Wu H, Wang X, Buchholz B, McCarthy S, Gu Z, Bianchi CF, Sellke FW, Laham R. Paclitaxel/sirolimus combination coated drug-eluting stent: in vitro and in vivo drug release studies. J Pharm Biomed Anal. 2011 Mar 25; 54(4):807-11. PMID: 21126843.
    Citations: 8     Fields:    Translation:Animals
  33. Robich MP, Chu LM, Feng J, Burgess TA, Laham RJ, Bianchi C, Sellke FW. Effects of selective cyclooxygenase-2 and nonselective cyclooxygenase inhibition on ischemic myocardium. J Thorac Cardiovasc Surg. 2010 Nov; 140(5):1143-52. PMID: 20804993.
    Citations: 5     Fields:    Translation:Animals
  34. Robich MP, Osipov RM, Nezafat R, Feng J, Clements RT, Bianchi C, Boodhwani M, Coady MA, Laham RJ, Sellke FW. Resveratrol improves myocardial perfusion in a swine model of hypercholesterolemia and chronic myocardial ischemia. Circulation. 2010 Sep 14; 122(11 Suppl):S142-9. PMID: 20837905.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  35. Robich MP, Matyal R, Chu LM, Feng J, Xu SH, Laham RJ, Hess PE, Bianchi C, Sellke FW. Effects of neuropeptide Y on collateral development in a swine model of chronic myocardial ischemia. J Mol Cell Cardiol. 2010 Dec; 49(6):1022-30. PMID: 20826160.
    Citations: 13     Fields:    Translation:Animals
  36. Robich MP, Osipov RM, Chu LM, Feng J, Burgess TA, Oyamada S, Clements RT, Laham RJ, Sellke FW. Temporal and spatial changes in collateral formation and function during chronic myocardial ischemia. J Am Coll Surg. 2010 Oct; 211(4):470-80. PMID: 20729101.
    Citations: 1     Fields:    Translation:Animals
  37. Robich MP, Chu LM, Chaudray M, Nezafat R, Han Y, Clements RT, Laham RJ, Manning WJ, Coady MA, Sellke FW. Anti-angiogenic effect of high-dose resveratrol in a swine model of metabolic syndrome. Surgery. 2010 Aug; 148(2):453-62. PMID: 20570307.
    Citations: 16     Fields:    Translation:Animals
  38. Laham RJ. The treatment of peripheral vascular disease: scio me nihil scire. J Invasive Cardiol. 2009 Jun; 21(6):282. PMID: 19494405.
    Citations:    Fields:    Translation:Humans
  39. Wykrzykowska J, Lehman S, Williams G, Parker JA, Palmer MR, Varkey S, Kolodny G, Laham R. Imaging of inflamed and vulnerable plaque in coronary arteries with 18F-FDG PET/CT in patients with suppression of myocardial uptake using a low-carbohydrate, high-fat preparation. J Nucl Med. 2009 Apr; 50(4):563-8. PMID: 19289431.
    Citations: 75     Fields:    Translation:Humans
  40. Sodha NR, Clements RT, Boodhwani M, Xu SH, Laham RJ, Bianchi C, Sellke FW. Endostatin and angiostatin are increased in diabetic patients with coronary artery disease and associated with impaired coronary collateral formation. Am J Physiol Heart Circ Physiol. 2009 Feb; 296(2):H428-34. PMID: 19074676.
    Citations: 34     Fields:    Translation:Humans
  41. Wu G, Rana JS, Wykrzykowska J, Du Z, Ke Q, Kang P, Li J, Laham RJ. Exercise-induced expression of VEGF and salvation of myocardium in the early stage of myocardial infarction. Am J Physiol Heart Circ Physiol. 2009 Feb; 296(2):H389-95. PMID: 19060119.
    Citations: 17     Fields:    Translation:Animals
  42. Wykrzykowska JJ, Piazza G, Laham RJ. Intracavitary pressure wire and intravascular ultrasound for the evaluation of combined symmetric hypertrophic cardiomyopathy and aortic stenosis in a patient with dyspnea and syncope: treatment with ethanol septal ablation. J Invasive Cardiol. 2008 May; 20(5):E171-3. PMID: 18460722.
    Citations:    Fields:    Translation:Humans
  43. Wu GF, Wykrzykowska JJ, Rana JS, Pinto DS, Gibson CM, Li J, Sellke FW, Laham RJ. Effects of B-type natriuretic peptide (nesiritide) on coronary epicardial arteries, systemic vasculature and microvessels. J Invasive Cardiol. 2008 Feb; 20(2):76-80. PMID: 18252972.
    Citations:    Fields:    Translation:Animals
  44. Laham RJ. Anecdotal vs. evidence-based, off label use of drug eluting stents for infrapopliteal disease: abusus non tollit usum (misuse does not nullify proper use). Catheter Cardiovasc Interv. 2008 Jan 01; 71(1):112-3. PMID: 18098212.
    Citations:    Fields:    Translation:Humans
  45. Wykrzykowska JJ, Williams M, Laham RJ. Stabilization of renal function, improvement in blood pressure control and pulmonary edema symptoms after opening a totally occluded renal artery. J Invasive Cardiol. 2008 Jan; 20(1):E26-9. PMID: 18174627.
    Citations: 2     Fields:    Translation:Humans
  46. Voisine P, Rosinberg A, Wykrzykowska JJ, Shamis Y, Wu GF, Appelbaum E, Li J, Sellke FW, Pinto D, Gibson CM, Mitrani E, Laham RJ. Skin-derived microorgan autotransplantation as a novel approach for therapeutic angiogenesis. Am J Physiol Heart Circ Physiol. 2008 Jan; 294(1):H213-9. PMID: 17965291.
    Citations: 1     Fields:    Translation:AnimalsCells
  47. Pinto DS, Kirtane AJ, Nallamothu BK, Murphy SA, Cohen DJ, Laham RJ, Cutlip DE, Bates ER, Frederick PD, Miller DP, Carrozza JP, Antman EM, Cannon CP, Gibson CM. Hospital delays in reperfusion for ST-elevation myocardial infarction: implications when selecting a reperfusion strategy. Circulation. 2006 Nov 07; 114(19):2019-25. PMID: 17075010.
    Citations: 55     Fields:    Translation:Humans
  48. Boodhwani M, Sodha NR, Laham RJ, Sellke FW. The future of therapeutic myocardial angiogenesis. Shock. 2006 Oct; 26(4):332-41. PMID: 16980878.
    Citations: 14     Fields:    Translation:HumansAnimals
  49. Sperling RT, Ho K, James D, Laham R, Gibson M, Carrozza J. Treatment of stent-jailed side branch stenoses with rotational atherectomy. J Invasive Cardiol. 2006 Aug; 18(8):354-8. PMID: 16877781.
    Citations: 1     Fields:    Translation:Humans
  50. Mieno S, Boodhwani M, Ramlawi B, Li J, Feng J, Bianchi C, Laham RJ, Li J, Sellke FW. Human coronary microvascular effects of cardioplegia-induced stromal-derived factor-1alpha. Ann Thorac Surg. 2006 Aug; 82(2):657-63. PMID: 16863781.
    Citations: 3     Fields:    Translation:HumansCells
  51. Wykrzykowska JJ, Carrozza J, Laham RJ. Aortocoronary dissection with acute left main artery occlusion: successful treatment with emergent stenting. J Invasive Cardiol. 2006 Aug; 18(8):E217-20. PMID: 16877790.
    Citations: 4     Fields:    Translation:Humans
  52. Boodhwani M, Nakai Y, Voisine P, Feng J, Li J, Mieno S, Ramlawi B, Bianchi C, Laham R, Sellke FW. High-dose atorvastatin improves hypercholesterolemic coronary endothelial dysfunction without improving the angiogenic response. Circulation. 2006 Jul 04; 114(1 Suppl):I402-8. PMID: 16820608.
    Citations: 13     Fields:    Translation:AnimalsCells
  53. Sellke FW, Laham R, Suuronen EJ, Ruel M. Angiogenesis for the treatment of inoperable coronary disease: the future. Semin Cardiothorac Vasc Anesth. 2006 Jun; 10(2):184-8. PMID: 16959748.
    Citations: 1     Fields:    Translation:HumansAnimals
  54. Wykrzykowska JJ, Kwaku K, Wylie J, Manning WJ, Josephson ME, Zimetbaum P, Laham RJ. Delayed occurrence of unheralded phase IV complete heart block after ethanol septal ablation for symmetric hypertrophic obstructive cardiomyopathy. Pacing Clin Electrophysiol. 2006 Jun; 29(6):674-8. PMID: 16784435.
    Citations: 1     Fields:    Translation:Humans
  55. Boodhwani M, Ramlawi B, Laham RJ, Sellke FW. Targeting vascular endothelial growth factor in angina therapy. Expert Opin Ther Targets. 2006 Feb; 10(1):5-14. PMID: 16441224.
    Citations:    Fields:    Translation:HumansAnimals
  56. Lee SU, Wykrzykowska JJ, Laham RJ. Angiogenesis: bench to bedside, have we learned anything? Toxicol Pathol. 2006; 34(1):3-10. PMID: 16507538.
    Citations: 3     Fields:    Translation:HumansAnimals
  57. Wu G, Luo J, Rana JS, Laham R, Sellke FW, Li J. Involvement of COX-2 in VEGF-induced angiogenesis via P38 and JNK pathways in vascular endothelial cells. Cardiovasc Res. 2006 Feb 01; 69(2):512-9. PMID: 16336951.
    Citations: 52     Fields:    Translation:HumansCells
  58. Laham RJ. Drug eluting stents for everyone and everything? Catheter Cardiovasc Interv. 2005 Dec; 66(4):512-3. PMID: 16270362.
    Citations:    Fields:    Translation:Humans
  59. Leon MB, Kornowski R, Downey WE, Weisz G, Baim DS, Bonow RO, Hendel RC, Cohen DJ, Gervino E, Laham R, Lembo NJ, Moses JW, Kuntz RE. A blinded, randomized, placebo-controlled trial of percutaneous laser myocardial revascularization to improve angina symptoms in patients with severe coronary disease. J Am Coll Cardiol. 2005 Nov 15; 46(10):1812-9. PMID: 16286164.
    Citations: 25     Fields:    Translation:Humans
  60. Wu G, Du Z, Hu C, Zheng Z, Zhan C, Ma H, Fang D, Ahmed KT, Laham RJ, Hui JC, Lawson WE. Angiogenic effects of long-term enhanced external counterpulsation in a dog model of myocardial infarction. Am J Physiol Heart Circ Physiol. 2006 Jan; 290(1):H248-54. PMID: 16113071.
    Citations: 9     Fields:    Translation:Animals
  61. Rana JS, Mannam A, Donnell-Fink L, Gervino EV, Sellke FW, Laham RJ. Longevity of the placebo effect in the therapeutic angiogenesis and laser myocardial revascularization trials in patients with coronary heart disease. Am J Cardiol. 2005 Jun 15; 95(12):1456-9. PMID: 15950570.
    Citations: 11     Fields:    Translation:Humans
  62. Laham RJ, Post M, Rezaee M, Donnell-Fink L, Wykrzykowska JJ, Lee SU, Baim DS, Sellke FW. Transendocardial and transepicardial intramyocardial fibroblast growth factor-2 administration: myocardial and tissue distribution. Drug Metab Dispos. 2005 Aug; 33(8):1101-7. PMID: 15879496.
    Citations: 11     Fields:    Translation:Animals
  63. Laham RJ. Yet another "weapon" to conquer the last remaining challenge in PCI. Catheter Cardiovasc Interv. 2004 Oct; 63(2):164-5. PMID: 15390341.
    Citations:    Fields:    Translation:Humans
  64. Voisine P, Bianchi C, Ruel M, Malik T, Rosinberg A, Feng J, Khan TA, Xu SH, Sandmeyer J, Laham RJ, Sellke FW. Inhibition of the cardiac angiogenic response to exogenous vascular endothelial growth factor. Surgery. 2004 Aug; 136(2):407-15. PMID: 15300208.
    Citations: 12     Fields:    Translation:AnimalsCells
  65. Shie JL, Wu G, Wu J, Liu FF, Laham RJ, Oettgen P, Li J. RTEF-1, a novel transcriptional stimulator of vascular endothelial growth factor in hypoxic endothelial cells. J Biol Chem. 2004 Jun 11; 279(24):25010-6. PMID: 15073166.
    Citations: 22     Fields:    Translation:AnimalsCells
  66. Wu J, Parungo C, Wu G, Kang PM, Laham RJ, Sellke FW, Simons M, Li J. PR39 inhibits apoptosis in hypoxic endothelial cells: role of inhibitor apoptosis protein-2. Circulation. 2004 Apr 06; 109(13):1660-7. PMID: 15023888.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  67. Ruel M, Wu GF, Khan TA, Voisine P, Bianchi C, Li J, Li J, Laham RJ, Sellke FW. Inhibition of the cardiac angiogenic response to surgical FGF-2 therapy in a Swine endothelial dysfunction model. Circulation. 2003 Sep 09; 108 Suppl 1:II335-40. PMID: 12970256.
    Citations: 16     Fields:    Translation:Animals
  68. Wu G, Mannam AP, Wu J, Kirbis S, Shie JL, Chen C, Laham RJ, Sellke FW, Li J. Hypoxia induces myocyte-dependent COX-2 regulation in endothelial cells: role of VEGF. Am J Physiol Heart Circ Physiol. 2003 Dec; 285(6):H2420-9. PMID: 12881220.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  69. Laham RJ, Li J, Tofukuji M, Post M, Simons M, Sellke FW. Spatial heterogeneity in VEGF-induced vasodilation: VEGF dilates microvessels but not epicardial and systemic arteries and veins. Ann Vasc Surg. 2003 May; 17(3):245-52. PMID: 12704544.
    Citations: 11     Fields:    Translation:AnimalsCells
  70. Laham RJ, Rezaee M, Post M, Xu X, Sellke FW. Intrapericardial administration of basic fibroblast growth factor: myocardial and tissue distribution and comparison with intracoronary and intravenous administration. Catheter Cardiovasc Interv. 2003 Mar; 58(3):375-81. PMID: 12594706.
    Citations: 9     Fields:    Translation:Animals
  71. Khan TA, Sellke FW, Laham RJ. Therapeutic angiogenesis: protein-based therapy for coronary artery disease. Expert Opin Pharmacother. 2003 Feb; 4(2):219-26. PMID: 12562312.
    Citations: 2     Fields:    Translation:HumansAnimals
  72. Khan TA, Sellke FW, Laham RJ. Gene therapy progress and prospects: therapeutic angiogenesis for limb and myocardial ischemia. Gene Ther. 2003 Feb; 10(4):285-91. PMID: 12595887.
    Citations: 30     Fields:    Translation:HumansAnimals
  73. Laham RJ, Oettgen P. Bone marrow transplantation for the heart: fact or fiction? Lancet. 2003 Jan 04; 361(9351):11-2. PMID: 12517456.
    Citations: 2     Fields:    Translation:Humans
  74. Rinfret S, Cutlip DE, Katsiyiannis PT, Ho KK, Cohen DJ, Carrozza JP, Laham RJ. Rheolytic thrombectomy and platelet glycoprotein IIb/IIIa blockade for stent thrombosis. Catheter Cardiovasc Interv. 2002 Sep; 57(1):24-30. PMID: 12203922.
    Citations: 1     Fields:    Translation:Humans
  75. Rinfret S, Katsiyiannis PT, Ho KK, Cohen DJ, Baim DS, Carrozza JP, Laham RJ. Effectiveness of rheolytic coronary thrombectomy with the AngioJet catheter. Am J Cardiol. 2002 Sep 01; 90(5):470-6. PMID: 12208404.
    Citations: 2     Fields:    Translation:Humans
  76. Ruel M, Laham RJ, Parker JA, Post MJ, Ware JA, Simons M, Sellke FW. Long-term effects of surgical angiogenic therapy with fibroblast growth factor 2 protein. J Thorac Cardiovasc Surg. 2002 Jul; 124(1):28-34. PMID: 12091805.
    Citations: 23     Fields:    Translation:HumansCTClinical Trials
  77. Post MJ, Laham RJ, Kuntz RE, Novicki D, Simons M. The effect of intracoronary fibroblast growth factor-2 on restenosis after primary angioplasty or stent placement in a pig model of atherosclerosis. Clin Cardiol. 2002 Jun; 25(6):271-8. PMID: 12058790.
    Citations: 1     Fields:    Translation:Animals
  78. Mannam AP, Ho KK, Cultip DE, Carrozza JP, Cohen DJ, Lorell BH, Laham RJ. Safety of subxyphoid pericardial access using a blunt-tip needle. Am J Cardiol. 2002 Apr 01; 89(7):891-3. PMID: 11909585.
    Citations:    Fields:    Translation:Humans
  79. Simons M, Annex BH, Laham RJ, Kleiman N, Henry T, Dauerman H, Udelson JE, Gervino EV, Pike M, Whitehouse MJ, Moon T, Chronos NA. Pharmacological treatment of coronary artery disease with recombinant fibroblast growth factor-2: double-blind, randomized, controlled clinical trial. Circulation. 2002 Feb 19; 105(7):788-93. PMID: 11854116.
    Citations: 121     Fields:    Translation:HumansCTClinical Trials
  80. Khan TA, Sellke FW, Laham RJ. Therapeutic Angiogenesis for Coronary Artery Disease. Curr Treat Options Cardiovasc Med. 2002 Feb; 4(1):65-74. PMID: 11792229.
    Citations: 2     
  81. Laham RJ, Simons M, Pearlman JD, Ho KK, Baim DS. Magnetic resonance imaging demonstrates improved regional systolic wall motion and thickening and myocardial perfusion of myocardial territories treated by laser myocardial revascularization. J Am Coll Cardiol. 2002 Jan 02; 39(1):1-8. PMID: 11755279.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  82. Pearlman JD, Laham RJ, Post M, Leiner T, Simons M. Medical imaging techniques in the evaluation of strategies for therapeutic angiogenesis. Curr Pharm Des. 2002; 8(16):1467-96. PMID: 12052207.
    Citations: 6     Fields:    Translation:HumansAnimals
  83. Laham RJ, Mannam A, Post MJ, Sellke F. Gene transfer to induce angiogenesis in myocardial and limb ischaemia. Expert Opin Biol Ther. 2001 Nov; 1(6):985-94. PMID: 11728230.
    Citations: 1     Fields:    Translation:Humans
  84. Bao J, Naimark W, Palasis M, Laham R, Simons M, Post MJ. Intramyocardial delivery of FGF2 in combination with radio frequency transmyocardial revascularization. Catheter Cardiovasc Interv. 2001 Jul; 53(3):429-34. PMID: 11458429.
    Citations:    Fields:    Translation:Animals
  85. Laham RJ, Baim DS. Combined percutaneous biosense-guided laser myocardial revascularization and coronary intervention. Catheter Cardiovasc Interv. 2001 Jun; 53(2):235-40. PMID: 11387612.
    Citations: 1     Fields:    Translation:Humans
  86. Laham R. Angiogenesis (clinical trials). Can J Cardiol. 2001 May; 17 Suppl A:29A-32A. PMID: 11381293.
    Citations: 2     Fields:    Translation:Humans
  87. Bush MA, Samara E, Whitehouse MJ, Yoshizawa C, Novicki DL, Pike M, Laham RJ, Simons M, Chronos NA. Pharmacokinetics and pharmacodynamics of recombinant FGF-2 in a phase I trial in coronary artery disease. J Clin Pharmacol. 2001 Apr; 41(4):378-85. PMID: 11304894.
    Citations: 8     Fields:    Translation:HumansCTClinical Trials
  88. Fuchs S, Hendel RC, Baim DS, Moses JW, Pierre A, Laham RJ, Hong MK, Kuntz RE, Pietrusewicz M, Bonow RO, Mintz GS, Leon MB, Kornowski R. Comparison of endocardial electromechanical mapping with radionuclide perfusion imaging to assess myocardial viability and severity of myocardial ischemia in angina pectoris. Am J Cardiol. 2001 Apr 01; 87(7):874-80. PMID: 11274943.
    Citations: 10     Fields:    Translation:Humans
  89. Xu X, Li J, Simons M, Li J, Laham RJ, Sellke FW. Expression of vascular endothelial growth factor and its receptors is increased, but microvascular relaxation is impaired in patients after acute myocardial ischemia. J Thorac Cardiovasc Surg. 2001 Apr; 121(4):735-42. PMID: 11279416.
    Citations: 4     Fields:    Translation:Humans
  90. Post MJ, Laham R, Sellke FW, Simons M. Therapeutic angiogenesis in cardiology using protein formulations. Cardiovasc Res. 2001 Feb 16; 49(3):522-31. PMID: 11166265.
    Citations: 32     Fields:    Translation:HumansAnimals
  91. Sato K, Wu T, Laham RJ, Johnson RB, Douglas P, Li J, Sellke FW, Bunting S, Simons M, Post MJ. Efficacy of intracoronary or intravenous VEGF165 in a pig model of chronic myocardial ischemia. J Am Coll Cardiol. 2001 Feb; 37(2):616-23. PMID: 11216988.
    Citations: 16     Fields:    Translation:Animals
  92. Laham RJ, Simons M, Sellke F. Gene transfer for angiogenesis in coronary artery disease. Annu Rev Med. 2001; 52:485-502. PMID: 11160791.
    Citations: 8     Fields:    Translation:Humans
  93. Laham RJ, Chronos NA, Pike M, Leimbach ME, Udelson JE, Pearlman JD, Pettigrew RI, Whitehouse MJ, Yoshizawa C, Simons M. Intracoronary basic fibroblast growth factor (FGF-2) in patients with severe ischemic heart disease: results of a phase I open-label dose escalation study. J Am Coll Cardiol. 2000 Dec; 36(7):2132-9. PMID: 11127452.
    Citations: 31     Fields:    Translation:HumansCTClinical Trials
  94. Sato K, Laham RJ, Pearlman JD, Novicki D, Sellke FW, Simons M, Post MJ. Efficacy of intracoronary versus intravenous FGF-2 in a pig model of chronic myocardial ischemia. Ann Thorac Surg. 2000 Dec; 70(6):2113-8. PMID: 11156130.
    Citations: 12     Fields:    Translation:Animals
  95. Udelson JE, Dilsizian V, Laham RJ, Chronos N, Vansant J, Blais M, Galt JR, Pike M, Yoshizawa C, Simons M. Therapeutic angiogenesis with recombinant fibroblast growth factor-2 improves stress and rest myocardial perfusion abnormalities in patients with severe symptomatic chronic coronary artery disease. Circulation. 2000 Oct 03; 102(14):1605-10. PMID: 11015335.
    Citations: 29     Fields:    Translation:HumansCTClinical Trials
  96. Simons M, Bonow RO, Chronos NA, Cohen DJ, Giordano FJ, Hammond HK, Laham RJ, Li W, Pike M, Sellke FW, Stegmann TJ, Udelson JE, Rosengart TK. Clinical trials in coronary angiogenesis: issues, problems, consensus: An expert panel summary. Circulation. 2000 Sep 12; 102(11):E73-86. PMID: 10982554.
    Citations: 85     Fields:    Translation:HumansAnimals
  97. Kornowski R, Baim DS, Moses JW, Hong MK, Laham RJ, Fuchs S, Hendel RC, Wallace D, Cohen DJ, Bonow RO, Kuntz RE, Leon MB. Short- and intermediate-term clinical outcomes from direct myocardial laser revascularization guided by biosense left ventricular electromechanical mapping. Circulation. 2000 Sep 05; 102(10):1120-5. PMID: 10973840.
    Citations: 6     Fields:    Translation:Humans
  98. Kumar A, Gambhir DS, Laham RJ. Current status of therapeutic angiogenesis. Indian Heart J. 2000 Sep-Oct; 52(5):604-14. PMID: 11256790.
    Citations:    Fields:    Translation:HumansAnimals
  99. Laham RJ, Post M, Sellke FW, Simons M. Therapeutic Angiogenesis Using Local Perivascular and Pericardial Delivery. Curr Interv Cardiol Rep. 2000 Aug; 2(3):213-217. PMID: 11096670.
    Citations: 1     
  100. Simons M, Laham RJ, Post M, Sellke FW. Therapeutic angiogenesis: potential role of basic fibroblast growth factor in patients with severe ischaemic heart disease. BioDrugs. 2000 Jul; 14(1):13-20. PMID: 18034552.
    Citations: 2     Fields:    
  101. Pearlman JD, Laham RJ, Simons M. Coronary angiogenesis: detection in vivo with MR imaging sensitive to collateral neocirculation--preliminary study in pigs. Radiology. 2000 Mar; 214(3):801-7. PMID: 10715049.
    Citations: 10     Fields:    Translation:HumansAnimals
  102. Laham RJ, Rezaee M, Post M, Novicki D, Sellke FW, Pearlman JD, Simons M, Hung D. Intrapericardial delivery of fibroblast growth factor-2 induces neovascularization in a porcine model of chronic myocardial ischemia. J Pharmacol Exp Ther. 2000 Feb; 292(2):795-802. PMID: 10640320.
    Citations: 25     Fields:    Translation:Animals
  103. Laham RJ, Sellke FW, Edelman ER, Pearlman JD, Ware JA, Brown DL, Gold JP, Simons M. Local perivascular delivery of basic fibroblast growth factor in patients undergoing coronary bypass surgery: results of a phase I randomized, double-blind, placebo-controlled trial. Circulation. 1999 Nov 02; 100(18):1865-71. PMID: 10545430.
    Citations: 50     Fields:    Translation:HumansCTClinical Trials
  104. Simons M, Laham RJ. Chronic myocardial ischemia: contemporary management strategies. Drugs Today (Barc). 1999 Sep; 35(9):667-84. PMID: 12973465.
    Citations:    Fields:    
  105. Laham RJ, Rezaee M, Post M, Sellke FW, Braeckman RA, Hung D, Simons M. Intracoronary and intravenous administration of basic fibroblast growth factor: myocardial and tissue distribution. Drug Metab Dispos. 1999 Jul; 27(7):821-6. PMID: 10383927.
    Citations: 19     Fields:    Translation:Animals
  106. Baim DS, Carrozza JP, Kuntz RE, Laham R. Managing the embolization problem during saphenous vein graft intervention. Catheter Cardiovasc Interv. 1999 Jun; 47(2):155-6. PMID: 10376494.
    Citations:    Fields:    Translation:Humans
  107. Laham RJ, Simons M, Hung D. Subxyphoid access of the normal pericardium: a novel drug delivery technique. Catheter Cardiovasc Interv. 1999 May; 47(1):109-11. PMID: 10385173.
    Citations: 6     Fields:    Translation:Animals
  108. Zimetbaum PJ, Schreckengost VE, Cohen DJ, Lemery R, Love D, Epstein LM, Laham R, Josephson ME. Evaluation of outpatient initiation of antiarrhythmic drug therapy in patients reverting to sinus rhythm after an episode of atrial fibrillation. Am J Cardiol. 1999 Feb 01; 83(3):450-2, A9. PMID: 10072241.
    Citations:    Fields:    Translation:HumansPHPublic HealthCTClinical Trials
  109. Laham RJ, Hung D, Simons M. Therapeutic myocardial angiogenesis using percutaneous intrapericardial drug delivery. Clin Cardiol. 1999 Jan; 22(1 Suppl 1):I6-9. PMID: 9929761.
    Citations: 2     Fields:    Translation:Animals
  110. Gibson CM, Ryan K, Sparano A, Moynihan JL, Rizzo M, Kelley M, Marble SJ, Laham R, Simons M, McClusky TR, Dodge JT. Angiographic methods to assess human coronary angiogenesis. Am Heart J. 1999 Jan; 137(1):169-79. PMID: 9878950.
    Citations: 13     Fields:    Translation:Humans
  111. Laham RJ, Simons M, Tofukuji M, Hung D, Sellke FW. Modulation of myocardial perfusion and vascular reactivity by pericardial basic fibroblast growth factor: insight into ischemia-induced reduction in endothelium-dependent vasodilatation. J Thorac Cardiovasc Surg. 1998 Dec; 116(6):1022-8. PMID: 9832695.
    Citations: 7     Fields:    Translation:Animals
  112. Dauerman HL, Higgins PJ, Sparano AM, Gibson CM, Garber GR, Carrozza JP, Kuntz RE, Laham RJ, Shubrooks SJ, Baim DS, Cohen DJ. Mechanical debulking versus balloon angioplasty for the treatment of true bifurcation lesions. J Am Coll Cardiol. 1998 Dec; 32(7):1845-52. PMID: 9857861.
    Citations: 6     Fields:    Translation:Humans
  113. Lopez JJ, Laham RJ, Stamler A, Pearlman JD, Bunting S, Kaplan A, Carrozza JP, Sellke FW, Simons M. VEGF administration in chronic myocardial ischemia in pigs. Cardiovasc Res. 1998 Nov; 40(2):272-81. PMID: 9893720.
    Citations: 32     Fields:    Translation:Animals
  114. Sellke FW, Laham RJ, Edelman ER, Pearlman JD, Simons M. Therapeutic angiogenesis with basic fibroblast growth factor: technique and early results. Ann Thorac Surg. 1998 Jun; 65(6):1540-4. PMID: 9647055.
    Citations: 28     Fields:    Translation:HumansCTClinical Trials
  115. Sellke FW, Tofukuji M, Laham RJ, Li J, Hariawala MD, Bunting S, Simons M. Comparison of VEGF delivery techniques on collateral-dependent microvascular reactivity. Microvasc Res. 1998 Mar; 55(2):175-8. PMID: 9521892.
    Citations: 2     Fields:    Translation:Animals
  116. Li J, Brown LF, Laham RJ, Volk R, Simons M. Macrophage-dependent regulation of syndecan gene expression. Circ Res. 1997 Nov; 81(5):785-96. PMID: 9351452.
    Citations: 24     Fields:    Translation:AnimalsCells
  117. Pearlman JD, Laham RJ, Simons M, Gladstone S, Raptopoulos V. Extent of myocardial collateralization: determination with three-dimensional elastic-subtraction spiral CT. Acad Radiol. 1997 Oct; 4(10):680-6. PMID: 9344290.
    Citations: 2     Fields:    Translation:Animals
  118. Lopez JJ, Laham RJ, Carrozza JP, Tofukuji M, Sellke FW, Bunting S, Simons M. Hemodynamic effects of intracoronary VEGF delivery: evidence of tachyphylaxis and NO dependence of response. Am J Physiol. 1997 Sep; 273(3 Pt 2):H1317-23. PMID: 9321821.
    Citations: 13     Fields:    Translation:Animals
  119. Laham RJ, Ho KK, Baim DS, Kuntz RE, Cohen DJ, Carrozza JP. Multivessel Palmaz-Schatz stenting: early results and one-year outcome. J Am Coll Cardiol. 1997 Jul; 30(1):180-5. PMID: 9207640.
    Citations: 2     Fields:    Translation:Humans
  120. Sukin CA, Baim DS, Caputo RP, Ho KK, Laham RJ, Flatley MG, Carrozza JP, Cohen DJ. The impact of optimal stenting techniques on cardiac catheterization laboratory resource utilization and costs. Am J Cardiol. 1997 Feb 01; 79(3):275-80. PMID: 9036744.
    Citations: 1     Fields:    Translation:Humans
  121. Laham RJ, Carrozza JP, Berger C, Cohen DJ, Kuntz RE, Baim DS. Long-term (4- to 6-year) outcome of Palmaz-Schatz stenting: paucity of late clinical stent-related problems. J Am Coll Cardiol. 1996 Oct; 28(4):820-6. PMID: 8837554.
    Citations: 13     Fields:    Translation:Humans
  122. Laham RJ, Cohen DJ, Kuntz RE, Baim DS, Lorell BH, Simons M. Pericardial effusion in patients with cancer: outcome with contemporary management strategies. Heart. 1996 Jan; 75(1):67-71. PMID: 8624876.
    Citations: 17     Fields:    Translation:Humans
  123. Laham RJ, Carrozza JP, Baim DS. Treatment of unprotected left main stenoses with Palmaz-Schatz stenting. Cathet Cardiovasc Diagn. 1996 Jan; 37(1):77-80. PMID: 8770487.
    Citations:    Fields:    Translation:Humans
  124. Laham RJ, Ho KK, Douglas PS, Faherty CE, Lock JE, Baim DS, Kuntz RE. Right ventricular infarction complicated by acute right-to-left shunting. Am J Cardiol. 1994 Oct 15; 74(8):824-6. PMID: 7942562.
    Citations: 5     Fields:    Translation:Humans
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.