Harvard Catalyst Profiles

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Timothy M. Shoup, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Yuan G, Guehl NJ, Zheng B, Qu X, Moon SH, Dhaynaut M, Shoup TM, Afshar S, Kang HJ, Zhang Z, El Fakhri G, Normandin MD, Brownell AL. Synthesis and Characterization of [18F]JNJ-46356479 as the First 18F-Labeled PET Imaging Ligand for Metabotropic Glutamate Receptor 2. Mol Imaging Biol. 2021 Feb 08. PMID: 33559035.
    Citations:    Fields:    
  2. Shoup TM, Griciuc A, Normandin MD, Quinti L, Walsh LV, Dhaynaut M, Moon SH, Guehl NJ, Brugarolas P, Elmaleh DR, Fakhri GE, Tanzi RE. Evaluation of Fluorinated Cromolyn Derivatives as Potential Therapeutics for Alzheimer's Disease. J Alzheimers Dis. 2021; 80(2):775-786. PMID: 33579853.
    Citations:    Fields:    
  3. Yuan G, Shoup TM, Moon SH, Brownell AL. A concise method for fully automated radiosyntheses of [18F]JNJ-46356479 and [18F]FITM via Cu-mediated 18F-fluorination of organoboranes. RSC Adv. 2020 Jul 02; 10(42):25223-25227. PMID: 33014351.
  4. Wang J, Qu X, Shoup TM, Yuan G, Afshar S, Pan C, Zhu A, Choi JK, Kang HJ, Poutiainen P, El Fakhri G, Zhang Z, Brownell AL. Synthesis and Characterization of Fluorine-18-Labeled N-(4-Chloro-3-((fluoromethyl-d2)thio)phenyl)picolinamide for Imaging of mGluR4 in Brain. J Med Chem. 2020 03 26; 63(6):3381-3389. PMID: 32081008.
    Citations:    Fields:    Translation:AnimalsCells
  5. Wang J, Shoup TM, Brownell AL, Zhang Z. Improved Synthesis of the Thiophenol Precursor N-(4-Chloro-3-mercaptophenyl)picolinamide for Making the mGluR4 PET Ligand. Tetrahedron. 2019 Jul 19; 75(29):3917-3922. PMID: 32831413.
    Citations:    Fields:    
  6. Verwer EE, Kavanagh TR, Mischler WJ, Feng Y, Takahashi K, Wang S, Shoup TM, Neelamegam R, Yang J, Guehl NJ, Ran C, Massefski W, Cui Y, El-Chemaly S, Sadow PM, Oldham WM, Kijewski MF, El Fakhri G, Normandin MD, Priolo C. [18F]Fluorocholine and [18F]Fluoroacetate PET as Imaging Biomarkers to Assess Phosphatidylcholine and Mitochondrial Metabolism in Preclinical Models of TSC and LAM. Clin Cancer Res. 2018 12 01; 24(23):5925-5938. PMID: 30054282.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  7. Alpert NM, Guehl N, Ptaszek L, Pelletier-Galarneau M, Ruskin J, Mansour MC, Wooten D, Ma C, Takahashi K, Zhou Y, Shoup TM, Normandin MD, El Fakhri G. Quantitative in vivo mapping of myocardial mitochondrial membrane potential. PLoS One. 2018; 13(1):e0190968. PMID: 29338024.
    Citations: 6     Fields:    Translation:Animals
  8. Guehl NJ, Normandin MD, Wooten DW, Rozen G, Ruskin JN, Shoup TM, Woo J, Ptaszek LM, Fakhri GE, Alpert NM. Rapid computation of single PET scan rest-stress myocardial blood flow parametric images by table look up. Med Phys. 2017 Sep; 44(9):4643-4651. PMID: 28594441.
    Citations:    Fields:    Translation:HumansAnimals
  9. Guehl NJ, Normandin MD, Wooten DW, Rozen G, Sitek A, Ruskin J, Shoup TM, Ptaszek LM, El Fakhri G, Alpert NM. Single-scan rest/stress imaging: validation in a porcine model with 18F-Flurpiridaz. Eur J Nucl Med Mol Imaging. 2017 Aug; 44(9):1538-1546. PMID: 28365789.
    Citations: 4     Fields:    Translation:Animals
  10. Petibon Y, Guehl NJ, Reese TG, Ebrahimi B, Normandin MD, Shoup TM, Alpert NM, El Fakhri G, Ouyang J. Impact of motion and partial volume effects correction on PET myocardial perfusion imaging using simultaneous PET-MR. Phys Med Biol. 2017 01 21; 62(2):326-343. PMID: 27997375.
    Citations: 11     Fields:    Translation:Animals
  11. Wooten DW, Guehl NJ, Verwer EE, Shoup TM, Yokell DL, Zubcevik N, Vasdev N, Zafonte RD, Johnson KA, El Fakhri G, Normandin MD. Pharmacokinetic Evaluation of the Tau PET Radiotracer 18F-T807 (18F-AV-1451) in Human Subjects. J Nucl Med. 2017 Mar; 58(3):484-491. PMID: 27660144.
    Citations: 28     Fields:    Translation:Humans
  12. Johnson KA, Schultz A, Betensky RA, Becker JA, Sepulcre J, Rentz D, Mormino E, Chhatwal J, Amariglio R, Papp K, Marshall G, Albers M, Mauro S, Pepin L, Alverio J, Judge K, Philiossaint M, Shoup T, Yokell D, Dickerson B, Gomez-Isla T, Hyman B, Vasdev N, Sperling R. Tau positron emission tomographic imaging in aging and early Alzheimer disease. Ann Neurol. 2016 Jan; 79(1):110-9. PMID: 26505746.
    Citations: 291     Fields:    Translation:Humans
  13. Liang SH, Southon AG, Fraser BH, Krause-Heuer AM, Zhang B, Shoup TM, Lewis R, Volitakis I, Han Y, Greguric I, Bush AI, Vasdev N. Novel Fluorinated 8-Hydroxyquinoline Based Metal Ionophores for Exploring the Metal Hypothesis of Alzheimer's Disease. ACS Med Chem Lett. 2015 Sep 10; 6(9):1025-9. PMID: 26396692.
    Citations: 9     
  14. Shoup TM, Bonab AA, Wilson AA, Vasdev N. Synthesis and preclinical evaluation of [¹8F]FCHC for neuroimaging of fatty acid amide hydrolase. Mol Imaging Biol. 2015 Apr; 17(2):257-63. PMID: 25273322.
    Citations: 4     Fields:    Translation:Animals
  15. Heidari P, Deng F, Esfahani SA, Leece AK, Shoup TM, Vasdev N, Mahmood U. Pharmacodynamic imaging guides dosing of a selective estrogen receptor degrader. Clin Cancer Res. 2015 Mar 15; 21(6):1340-7. PMID: 25609068.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  16. Hori Y, Takeda S, Cho H, Wegmann S, Shoup TM, Takahashi K, Irimia D, Elmaleh DR, Hyman BT, Hudry E. A Food and Drug Administration-approved asthma therapeutic agent impacts amyloid ß in the brain in a transgenic model of Alzheimer disease. J Biol Chem. 2015 Jan 23; 290(4):1966-78. PMID: 25468905.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  17. Tian Y, Zhang X, Li Y, Shoup TM, Teng X, Elmaleh DR, Moore A, Ran C. Crown ethers attenuate aggregation of amyloid beta of Alzheimer's disease. Chem Commun (Camb). 2014 Dec 25; 50(99):15792-5. PMID: 25372154.
    Citations: 2     Fields:    Translation:Animals
  18. Liang SH, Yokell DL, Normandin MD, Rice PA, Jackson RN, Shoup TM, Brady TJ, Fakhri GE, Collier TL, Vasdev N. First Human Use of a Radiopharmaceutical Prepared by Continuous-Flow Microfluidic Radiofluorination: Proof of Concept with the Tau Imaging Agent [18F]T807. Mol Imaging. 2014 Oct 01; 13(8):7290201400025. PMID: 28650281.
  19. Rotstein BH, Wey HY, Shoup TM, Wilson AA, Liang SH, Hooker JM, Vasdev N. PET imaging of fatty acid amide hydrolase with [(18)F]DOPP in nonhuman primates. Mol Pharm. 2014 Nov 03; 11(11):3832-8. PMID: 25004399.
    Citations: 5     Fields:    Translation:Animals
  20. Zhao G, Yu YM, Shoup TM, Elmaleh DR, Bonab AA, Tompkins RG, Fischman AJ. Membrane potential-dependent uptake of 18F-triphenylphosphonium--a new voltage sensor as an imaging agent for detecting burn-induced apoptosis. J Surg Res. 2014 May 15; 188(2):473-9. PMID: 24582214.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  21. Liang SH, Yokell DL, Normandin MD, Rice PA, Jackson RN, Shoup TM, Brady TJ, El Fakhri G, Collier TL, Vasdev N. First human use of a radiopharmaceutical prepared by continuous-flow microfluidic radiofluorination: proof of concept with the tau imaging agent [18F]T807. Mol Imaging. 2014; 13. PMID: 25248283.
    Citations: 5     Fields:    Translation:Humans
  22. Shoup TM, Yokell DL, Rice PA, Jackson RN, Livni E, Johnson KA, Brady TJ, Vasdev N. A concise radiosynthesis of the tau radiopharmaceutical, [(18) F]T807. J Labelled Comp Radiopharm. 2013 Dec; 56(14):736-40. PMID: 24339014.
    Citations: 33     Fields:    
  23. Larvie M, Shoup T, Chang WC, Chigweshe L, Hartshorn K, White MR, Stahl GL, Elmaleh DR, Takahashi K. Mannose-binding lectin binds to amyloid ß protein and modulates inflammation. J Biomed Biotechnol. 2012; 2012:929803. PMID: 22536027.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  24. Gurm GS, Danik SB, Shoup TM, Weise S, Takahashi K, Laferrier S, Elmaleh DR, Gewirtz H. 4-[18F]-tetraphenylphosphonium as a PET tracer for myocardial mitochondrial membrane potential. JACC Cardiovasc Imaging. 2012 Mar; 5(3):285-92. PMID: 22421174.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  25. Shoup TM, Elmaleh DR, Brownell AL, Zhu A, Guerrero JL, Fischman AJ. Evaluation of (4-[18F]Fluorophenyl)triphenylphosphonium ion. A potential myocardial blood flow agent for PET. Mol Imaging Biol. 2011 Jun; 13(3):511-517. PMID: 20563755.
    Citations: 18     Fields:    Translation:Animals
  26. Gomperts SN, Rentz DM, Moran E, Becker JA, Locascio JJ, Klunk WE, Mathis CA, Elmaleh DR, Shoup T, Fischman AJ, Hyman BT, Growdon JH, Johnson KA. Imaging amyloid deposition in Lewy body diseases. Neurology. 2008 Sep 16; 71(12):903-10. PMID: 18794492.
    Citations: 151     Fields:    Translation:Humans
  27. Elmaleh DR, Fischman AJ, Tawakol A, Zhu A, Shoup TM, Hoffmann U, Brownell AL, Zamecnik PC. Detection of inflamed atherosclerotic lesions with diadenosine-5',5'''-P1,P4-tetraphosphate (Ap4A) and positron-emission tomography. Proc Natl Acad Sci U S A. 2006 Oct 24; 103(43):15992-6. PMID: 17038498.
    Citations: 10     Fields:    Translation:AnimalsCells
  28. Shoup TM, Elmaleh DR, Bonab AA, Fischman AJ. Evaluation of trans-9-18F-fluoro-3,4-Methyleneheptadecanoic acid as a PET tracer for myocardial fatty acid imaging. J Nucl Med. 2005 Feb; 46(2):297-304. PMID: 15695790.
    Citations: 12     Fields:    Translation:Animals
  29. Choi SW, Elmaleh DR, Hanson RN, Shoup TM, Fischman AJ. Novel (bisarylmethoxy)butylpiperidine analogues as neurotransmitter transporter inhibitors with activity at dopamine receptor sites. Bioorg Med Chem. 2002 Dec; 10(12):4091-102. PMID: 12413863.
    Citations:    Fields:    Translation:HumansAnimalsCells
  30. Femia FJ, Chen X, Maresca KP, Shoup TM, Babich JW, Zubieta J. Synthesis and characterization of complexes of the {ReO} core with SNS and S donor ligands. Inorganica Chim Acta. 2000 Aug; 306(1):30-37. PMID: 20628539.
    Citations: 3     
  31. Kabalka GW, Shoup TM, Daniel GB, Goodman MM. Synthesis and evaluation of a new series of 17alpha-[(123)I]iodovinyl estradiols. Nucl Med Biol. 2000 Apr; 27(3):279-87. PMID: 10832085.
    Citations: 1     Fields:    Translation:Animals
  32. Votaw JR, Henry TR, Shoup TM, Hoffman JM, Woodard JL, Goodman MM. Butanol is superior to water for performing positron emission tomography activation studies. J Cereb Blood Flow Metab. 1999 Sep; 19(9):982-9. PMID: 10478649.
    Citations:    Fields:    Translation:Humans
  33. Shoup TM, Olson J, Hoffman JM, Votaw J, Eshima D, Eshima L, Camp VM, Stabin M, Votaw D, Goodman MM. Synthesis and evaluation of [18F]1-amino-3-fluorocyclobutane-1-carboxylic acid to image brain tumors. J Nucl Med. 1999 Feb; 40(2):331-8. PMID: 10025843.
    Citations: 43     Fields:    Translation:HumansAnimals
  34. Subramanian T, Emerich DF, Bakay RA, Hoffman JM, Goodman MM, Shoup TM, Miller GW, Levey AI, Hubert GW, Batchelor S, Winn SR, Saydoff JA, Watts RL. Polymer-encapsulated PC-12 cells demonstrate high-affinity uptake of dopamine in vitro and 18F-Dopa uptake and metabolism after intracerebral implantation in nonhuman primates. Cell Transplant. 1997 Sep-Oct; 6(5):469-77. PMID: 9331498.
    Citations: 5     Fields:    Translation:AnimalsCells
  35. Goodman MM, Keil R, Shoup TM, Eshima D, Eshima L, Kilts C, Votaw J, Camp VM, Votaw D, Smith E, Kung MP, Malveaux E, Watts R, Huerkamp M, Wu D, Garcia E, Hoffman JM. Fluorine-18-FPCT: a PET radiotracer for imaging dopamine transporters. J Nucl Med. 1997 Jan; 38(1):119-26. PMID: 8998165.
    Citations: 10     Fields:    Translation:Animals
  36. Fischman AJ, Bonab AA, Babich JW, Alpert NM, Rauch SL, Elmaleh DR, Shoup TM, Williams SA, Rubin RH. Positron emission tomographic analysis of central 5-hydroxytryptamine2 receptor occupancy in healthy volunteers treated with the novel antipsychotic agent, ziprasidone. J Pharmacol Exp Ther. 1996 Nov; 279(2):939-47. PMID: 8930203.
    Citations: 13     Fields:    Translation:Humans
  37. Brownell AL, Elmaleh DR, Meltzer PC, Shoup TM, Brownell GL, Fischman AJ, Madras BK. Cocaine congeners as PET imaging probes for dopamine terminals. J Nucl Med. 1996 Jul; 37(7):1186-92. PMID: 8965196.
    Citations: 5     Fields:    Translation:Animals
  38. Elmaleh DR, Fischman AJ, Shoup TM, Byon C, Hanson RN, Liang AY, Meltzer PC, Madras BK. Preparation and biological evaluation of iodine-125-IACFT: a selective SPECT agent for imaging dopamine transporter sites. J Nucl Med. 1996 Jul; 37(7):1197-202. PMID: 8965198.
    Citations: 3     Fields:    Translation:Animals
  39. Shoup TM, Fischman AJ, Jaywook S, Babich JW, Strauss HW, Elmaleh DR. Synthesis of fluorine-18-labeled biotin derivatives: biodistribution and infection localization. J Nucl Med. 1994 Oct; 35(10):1685-90. PMID: 7931672.
    Citations: 8     Fields:    Translation:Animals
  40. Wüllner U, Pakzaban P, Brownell AL, Hantraye P, Burns L, Shoup T, Elmaleh D, Petto AJ, Spealman RD, Brownell GL, et al. Dopamine terminal loss and onset of motor symptoms in MPTP-treated monkeys: a positron emission tomography study with 11C-CFT. Exp Neurol. 1994 Apr; 126(2):305-9. PMID: 7925829.
    Citations: 9     Fields:    
  41. Brownell AL, Hantraye P, Wullner U, Hamberg L, Shoup T, Elmaleh DR, Frim DM, Madras BK, Brownell GL, Rosen BR, et al. PET- and MRI-based assessment of glucose utilization, dopamine receptor binding, and hemodynamic changes after lesions to the caudate-putamen in primates. Exp Neurol. 1994 Jan; 125(1):41-51. PMID: 7905836.
    Citations: 2     Fields:    Translation:Animals
  42. Melder RJ, Brownell AL, Shoup TM, Brownell GL, Jain RK. Imaging of activated natural killer cells in mice by positron emission tomography: preferential uptake in tumors. Cancer Res. 1993 Dec 15; 53(24):5867-71. PMID: 8261395.
    Citations: 19     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.