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profileMasanori Aikawa, PH.D., M.D.

TitleAssociate Professor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham and Women's Hospital
Center for Excellence in Vascular Biology, NRB741J
77 Avenue Louis Pasteur
Boston MA 02115
Phone617/730-7777
Fax617/525-4400
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Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
Most Recent  |  List All
R01HL126901     (AIKAWA, MASANORI)Jan 1, 2016 - Dec 31, 2019
NIH/NHLBI
PARP9 and PARP14 in atherosclerosis
Role: Principal Investigator
R01HL107550     (AIKAWA, MASANORI)Jan 1, 2012 - Nov 30, 2015
NIH/NHLBI
Dll4 in macrophage activation
Role: Principal Investigator
R01HL066086     (AIKAWA, MASANORI)Apr 3, 2003 - Mar 31, 2007
NIH/NHLBI
Role of the CD40/CD40L dyad in atherosclerosis
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Goettsch C, Iwata H, Hutcheson JD, O'Donnell CJ, Chapurlat R, Cook NR, Aikawa M, Szulc P, Aikawa E. Serum Sortilin Associates With Aortic Calcification and Cardiovascular Risk in Men. Arterioscler Thromb Vasc Biol. 2017 May; 37(5):1005-1011. PMID: 28279970.
    View in: PubMed
  2. Singh SA, Aikawa M. Unbiased and targeted mass spectrometry for the HDL proteome. Curr Opin Lipidol. 2017 Feb; 28(1):68-77. PMID: 28002079.
    View in: PubMed
  3. Lee LH, Andraski AB, Pieper B, Higashi H, Sacks FM, Aikawa M, Singh SA. Automation of PRM-dependent D3-Leu tracer enrichment in HDL to study the metabolism of apoA-I, LCAT and other apolipoproteins. Proteomics. 2017 Jan; 17(1-2). PMID: 27862954.
    View in: PubMed
  4. Yabusaki K, Hutcheson JD, Vyas P, Bertazzo S, Body SC, Aikawa M, Aikawa E. Quantification of Calcified Particles in Human Valve Tissue Reveals Asymmetry of Calcific Aortic Valve Disease Development. Front Cardiovasc Med. 2016; 3:44. PMID: 27867942.
    View in: PubMed
  5. Iwata H, Goettsch C, Sharma A, Ricchiuto P, Goh WW, Halu A, Yamada I, Yoshida H, Hara T, Wei M, Inoue N, Fukuda D, Mojcher A, Mattson PC, Barabási AL, Boothby M, Aikawa E, Singh SA, Aikawa M. PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation. Nat Commun. 2016 Oct 31; 7:12849. PMID: 27796300.
    View in: PubMed
  6. Nakano T, Fukuda D, Koga J, Aikawa M. Delta-Like Ligand 4-Notch Signaling in Macrophage Activation. Arterioscler Thromb Vasc Biol. 2016 Oct; 36(10):2038-47. PMID: 27562914; PMCID: PMC5033717 [Available on 10/01/17].
    View in: PubMed, PubMed Central
  7. Singh SA, Aikawa E, Aikawa M. Current Trends and Future Perspectives of State-of-the-Art Proteomics Technologies Applied to Cardiovascular Disease Research. Circ J. 2016 Jul 25; 80(8):1674-83. PMID: 27430298.
    View in: PubMed
  8. Goettsch C, Hutcheson JD, Hagita S, Rogers MA, Creager MD, Pham T, Choi J, Mlynarchik AK, Pieper B, Kjolby M, Aikawa M, Aikawa E. A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification. Atherosclerosis. 2016 Aug; 251:109-118. PMID: 27318830; PMCID: PMC4983246 [Available on 02/01/17].
    View in: PubMed, PubMed Central
  9. Ghiassian SD, Menche J, Chasman DI, Giulianini F, Wang R, Ricchiuto P, Aikawa M, Iwata H, Müller C, Zeller T, Sharma A, Wild P, Lackner K, Singh S, Ridker PM, Blankenberg S, Barabási AL, Loscalzo J. Endophenotype Network Models: Common Core of Complex Diseases. Sci Rep. 2016 Jun 09; 6:27414. PMID: 27278246; PMCID: PMC4899691.
    View in: PubMed, PubMed Central
  10. Decano JL, Mattson PC, Aikawa M. Macrophages in Vascular Inflammation: Origins and Functions. Curr Atheroscler Rep. 2016 Jun; 18(6):34. PMID: 27125207.
    View in: PubMed
  11. Goettsch C, Hutcheson JD, Aikawa M, Iwata H, Pham T, Nykjaer A, Kjolby M, Rogers M, Michel T, Shibasaki M, Hagita S, Kramann R, Rader DJ, Libby P, Singh SA, Aikawa E. Sortilin mediates vascular calcification via its recruitment into extracellular vesicles. J Clin Invest. 2016 Apr 01; 126(4):1323-36. PMID: 26950419; PMCID: PMC4811143.
    View in: PubMed, PubMed Central
  12. Singh SA, Andraski AB, Pieper B, Goh W, Mendivil CO, Sacks FM, Aikawa M. Multiple apolipoprotein kinetics measured in human HDL by high-resolution/accurate mass parallel reaction monitoring. J Lipid Res. 2016 Apr; 57(4):714-28. PMID: 26862155; PMCID: PMC4808760 [Available on 04/01/17].
    View in: PubMed, PubMed Central
  13. Hutcheson JD, Goettsch C, Bertazzo S, Maldonado N, Ruiz JL, Goh W, Yabusaki K, Faits T, Bouten C, Franck G, Quillard T, Libby P, Aikawa M, Weinbaum S, Aikawa E. Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques. Nat Mater. 2016 Mar; 15(3):335-43. PMID: 26752654; PMCID: PMC4767675.
    View in: PubMed, PubMed Central
  14. Sun X, Haas ME, Miao J, Mehta A, Graham MJ, Crooke RM, Pais de Barros JP, Wang JG, Aikawa M, Masson D, Biddinger SB. Insulin Dissociates the Effects of Liver X Receptor on Lipogenesis, Endoplasmic Reticulum Stress, and Inflammation. J Biol Chem. 2016 Jan 15; 291(3):1115-22. PMID: 26511317; PMCID: PMC4714195 [Available on 01/15/17].
    View in: PubMed, PubMed Central
  15. Wang JG, Aikawa M. Toll-like receptors and Src-family kinases in atherosclerosis -- focus on macrophages. Circ J. 2015; 79(11):2332-4. PMID: 26467082.
    View in: PubMed
  16. Koga J, Nakano T, Dahlman JE, Figueiredo JL, Zhang H, Decano J, Khan OF, Niida T, Iwata H, Aster JC, Yagita H, Anderson DG, Ozaki CK, Aikawa M. Macrophage Notch Ligand Delta-Like 4 Promotes Vein Graft Lesion Development: Implications for the Treatment of Vein Graft Failure. Arterioscler Thromb Vasc Biol. 2015 Nov; 35(11):2343-53. PMID: 26404485; PMCID: PMC5003117 [Available on 11/01/16].
    View in: PubMed, PubMed Central
  17. Shibasaki M, Wang JG, Figueiredo JL, New SE, Quillard T, Goettsch C, Koga J, Sonoki H, Matsumoto J, Aikawa M, Aikawa E. Pitavastatin Reduces Inflammation in Atherosclerotic Plaques in Apolipoprotein E-Deficient Mice with Late Stage Renal Disease. PLoS One. 2015; 10(9):e0138047. PMID: 26367531; PMCID: PMC4569429.
    View in: PubMed, PubMed Central
  18. Singh SA, Miyosawa K, Aikawa M. Mass spectrometry meets the challenge of understanding the complexity of the lipoproteome: recent findings regarding proteins involved in dyslipidemia and cardiovascular disease. Expert Rev Proteomics. 2015; 12(5):519-32. PMID: 26325144.
    View in: PubMed
  19. Ricchiuto P, Iwata H, Yabusaki K, Yamada I, Pieper B, Sharma A, Aikawa M, Singh SA. mIMT-visHTS: A novel method for multiplexing isobaric mass tagged datasets with an accompanying visualization high throughput screening tool for protein profiling. J Proteomics. 2015 Oct 14; 128:132-40. PMID: 26232111.
    View in: PubMed
  20. Sasaki Y, Ohta M, Desai D, Figueiredo JL, Whelan MC, Sugano T, Yamabi M, Yano W, Faits T, Yabusaki K, Zhang H, Mlynarchik AK, Inoue K, Mizuno K, Aikawa M. Angiopoietin Like Protein 2 (ANGPTL2) Promotes Adipose Tissue Macrophage and T lymphocyte Accumulation and Leads to Insulin Resistance. PLoS One. 2015; 10(7):e0131176. PMID: 26132105; PMCID: PMC4489192.
    View in: PubMed, PubMed Central
  21. Miyosawa K, Watanabe Y, Murakami K, Murakami T, Shibata H, Iwashita M, Yamazaki H, Yamazaki K, Ohgiya T, Shibuya K, Mizuno K, Tanabe S, Singh SA, Aikawa M. New CETP inhibitor K-312 reduces PCSK9 expression: a potential effect on LDL cholesterol metabolism. Am J Physiol Endocrinol Metab. 2015 Jul 15; 309(2):E177-90. PMID: 26015437.
    View in: PubMed
  22. Lu H, Aikawa M. Many faces of matrix metalloproteinases in aortic aneurysms. Arterioscler Thromb Vasc Biol. 2015 Apr; 35(4):752-4. PMID: 25810296.
    View in: PubMed
  23. Figueiredo JL, Aikawa M, Zheng C, Aaron J, Lax L, Libby P, de Lima Filho JL, Gruener S, Fingerle J, Haap W, Hartmann G, Aikawa E. Selective cathepsin S inhibition attenuates atherosclerosis in apolipoprotein E-deficient mice with chronic renal disease. Am J Pathol. 2015 Apr; 185(4):1156-66. PMID: 25680278; PMCID: PMC4380840.
    View in: PubMed, PubMed Central
  24. Hutcheson JD, Goettsch C, Pham T, Iwashita M, Aikawa M, Singh SA, Aikawa E. Enrichment of calcifying extracellular vesicles using density-based ultracentrifugation protocol. J Extracell Vesicles. 2014; 3:25129. PMID: 25491249; PMCID: PMC4261240.
    View in: PubMed, PubMed Central
  25. Takase K, Aikawa M, Okada K, Watanabe Y, Okamoto K, Sato H, Nonaka K, Yamaguchi S, Sakuramoto S, Koyama I, Miyazawa M. Development of novel treatment with a bioabsorbable esophageal patch for benign esophageal stricture. Dis Esophagus. 2015 Nov-Dec; 28(8):728-34. PMID: 25286827.
    View in: PubMed
  26. Miyazaki T, Chiuve S, Sacks FM, Ridker PM, Libby P, Aikawa M. Plasma pentraxin 3 levels do not predict coronary events but reflect metabolic disorders in patients with coronary artery disease in the CARE trial. PLoS One. 2014; 9(4):e94073. PMID: 24705587; PMCID: PMC3976379.
    View in: PubMed, PubMed Central
  27. Yabusaki K, Faits T, McMullen E, Figueiredo JL, Aikawa M, Aikawa E. A novel quantitative approach for eliminating sample-to-sample variation using a hue saturation value analysis program. PLoS One. 2014; 9(3):e89627. PMID: 24595280; PMCID: PMC3940696.
    View in: PubMed, PubMed Central
  28. Koga J, Aikawa M. Application of anti-ligand antibodies to inhibit Notch signaling. Methods Mol Biol. 2014; 1187:335-42. PMID: 25053501.
    View in: PubMed
  29. Itou T, Maldonado N, Yamada I, Goettsch C, Matsumoto J, Aikawa M, Singh S, Aikawa E. Cystathionine ?-lyase accelerates osteoclast differentiation: identification of a novel regulator of osteoclastogenesis by proteomic analysis. Arterioscler Thromb Vasc Biol. 2014 Mar; 34(3):626-34. PMID: 24357058; PMCID: PMC3959796.
    View in: PubMed, PubMed Central
  30. Fukuda D, Aikawa M. Expanding role of delta-like 4 mediated notch signaling in cardiovascular and metabolic diseases. Circ J. 2013; 77(10):2462-8. PMID: 24025398; PMCID: PMC4545641.
    View in: PubMed, PubMed Central
  31. Wang JG, Aikawa E, Aikawa M. Leukocyte-derived microparticles as proinflammatory mediators in atherosclerosis. J Am Coll Cardiol. 2013 Oct 15; 62(16):1442-5. PMID: 23707315.
    View in: PubMed
  32. Zheng C, Morishige K, Aikawa M. Functional molecular imaging linking macrophages to reverse cholesterol transport. Circ J. 2013; 77(6):1403-6. PMID: 23685734.
    View in: PubMed
  33. New SE, Goettsch C, Aikawa M, Marchini JF, Shibasaki M, Yabusaki K, Libby P, Shanahan CM, Croce K, Aikawa E. Macrophage-derived matrix vesicles: an alternative novel mechanism for microcalcification in atherosclerotic plaques. Circ Res. 2013 Jun 21; 113(1):72-7. PMID: 23616621; PMCID: PMC3703850.
    View in: PubMed, PubMed Central
  34. Iwata H, Aikawa M. Liver-artery interactions via the plasminogen-CD36 axis in macrophage foam cell formation: new evidence for the role of remote organ crosstalk in atherosclerosis. Circulation. 2013 Mar 19; 127(11):1173-6. PMID: 23509031.
    View in: PubMed
  35. Abe J, Manabe I, Aikawa M, Aikawa E. Cardiovascular Inflammation 2012: Reactive Oxygen Species, SUMOylation, and Biomarkers in Cardiovascular Inflammation. Int J Inflam. 2013; 2013:953463. PMID: 23555068; PMCID: PMC3608100.
    View in: PubMed, PubMed Central
  36. Zheng C, Aikawa M. High-density lipoproteins: from function to therapy. J Am Coll Cardiol. 2012 Dec 11; 60(23):2380-3. PMID: 23141492.
    View in: PubMed
  37. Zheng C, Azcutia V, Aikawa E, Figueiredo JL, Croce K, Sonoki H, Sacks FM, Luscinskas FW, Aikawa M. Statins suppress apolipoprotein CIII-induced vascular endothelial cell activation and monocyte adhesion. Eur Heart J. 2013 Feb; 34(8):615-24. PMID: 22927557; PMCID: PMC3578265.
    View in: PubMed, PubMed Central
  38. Azcutia V, Stefanidakis M, Tsuboi N, Mayadas T, Croce KJ, Fukuda D, Aikawa M, Newton G, Luscinskas FW. Endothelial CD47 promotes vascular endothelial-cadherin tyrosine phosphorylation and participates in T cell recruitment at sites of inflammation in vivo. J Immunol. 2012 Sep 01; 189(5):2553-62. PMID: 22815286; PMCID: PMC3424398.
    View in: PubMed, PubMed Central
  39. Fukuda D, Aikawa E, Swirski FK, Novobrantseva TI, Kotelianski V, Gorgun CZ, Chudnovskiy A, Yamazaki H, Croce K, Weissleder R, Aster JC, Hotamisligil GS, Yagita H, Aikawa M. Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders. Proc Natl Acad Sci U S A. 2012 Jul 03; 109(27):E1868-77. PMID: 22699504; PMCID: PMC3390871.
    View in: PubMed, PubMed Central
  40. Aikawa M, Manabe I, Chester A, Aikawa E. Cardiovascular inflammation. Int J Inflam. 2012; 2012:904608. PMID: 22518345; PMCID: PMC3317089.
    View in: PubMed, PubMed Central
  41. Koga J, Aikawa M. Crosstalk between macrophages and smooth muscle cells in atherosclerotic vascular diseases. Vascul Pharmacol. 2012 Aug 19; 57(1):24-8. PMID: 22402259.
    View in: PubMed
  42. Quillard T, Tesmenitsky Y, Croce K, Travers R, Shvartz E, Koskinas KC, Sukhova GK, Aikawa E, Aikawa M, Libby P. Selective inhibition of matrix metalloproteinase-13 increases collagen content of established mouse atherosclerosis. Arterioscler Thromb Vasc Biol. 2011 Nov; 31(11):2464-72. PMID: 21903941; PMCID: PMC3200308.
    View in: PubMed, PubMed Central
  43. Umeda H, Aikawa M, Libby P. Liberation of desmosine and isodesmosine as amino acids from insoluble elastin by elastolytic proteases. Biochem Biophys Res Commun. 2011 Jul 29; 411(2):281-6. PMID: 21726534; PMCID: PMC3148299.
    View in: PubMed, PubMed Central
  44. Fukuda D, Aikawa M. Intimal smooth muscle cells: the context-dependent origin. Circulation. 2010 Nov 16; 122(20):2005-8. PMID: 21041686.
    View in: PubMed
  45. Morishige K, Kacher DF, Libby P, Josephson L, Ganz P, Weissleder R, Aikawa M. High-resolution magnetic resonance imaging enhanced with superparamagnetic nanoparticles measures macrophage burden in atherosclerosis. Circulation. 2010 Oct 26; 122(17):1707-15. PMID: 20937980; PMCID: PMC3003265.
    View in: PubMed, PubMed Central
  46. Bu DX, Tarrio M, Grabie N, Zhang Y, Yamazaki H, Stavrakis G, Maganto-Garcia E, Pepper-Cunningham Z, Jarolim P, Aikawa M, García-Cardeña G, Lichtman AH. Statin-induced Krüppel-like factor 2 expression in human and mouse T cells reduces inflammatory and pathogenic responses. J Clin Invest. 2010 Jun; 120(6):1961-70. PMID: 20440076; PMCID: PMC2877947.
    View in: PubMed, PubMed Central
  47. Zheng C, Sacks FM, Aikawa M. Modern Insights Into Diseases From Molecules to Man: Adhesion Molecules (Preedy V, ed). Apolipoproteins and adhesion molecules. 2010; 429-445.
  48. Morishige K, Kacher DF, Libby P, Josephson L, Ganz P, Weissleder R, Aikawa M. Circulation. High- resolution MRI enhanced with superparamagnetic nanoparticles measures macrophage burden in atherosclerosis. 2010; 122:1707-1715.
  49. Fukuda D, Aikawa M. Circulation. Intimal smooth muscle cells: the context-dependent origin. 2010; 122:2005-2008.
  50. Deguchi JO, Yamazaki H, Aikawa E, Aikawa M. Chronic hypoxia activates the Akt and beta-catenin pathways in human macrophages. Arterioscler Thromb Vasc Biol. 2009 Oct; 29(10):1664-70. PMID: 19644051.
    View in: PubMed
  51. Aikawa E, Aikawa M, Libby P, Figueiredo JL, Rusanescu G, Iwamoto Y, Fukuda D, Kohler RH, Shi GP, Jaffer FA, Weissleder R. Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease. Circulation. 2009 Apr 07; 119(13):1785-94. PMID: 19307473; PMCID: PMC2717745.
    View in: PubMed, PubMed Central
  52. Deguchi JO, Huang H, Libby P, Aikawa E, Whittaker P, Sylvan J, Lee RT, Aikawa M. Genetically engineered resistance for MMP collagenases promotes abdominal aortic aneurysm formation in mice infused with angiotensin II. Lab Invest. 2009 Mar; 89(3):315-26. PMID: 19153555; PMCID: PMC2932654.
    View in: PubMed, PubMed Central
  53. Sun Y, Ishibashi M, Seimon T, Lee M, Sharma SM, Fitzgerald KA, Samokhin AO, Wang Y, Sayers S, Aikawa M, Jerome WG, Ostrowski MC, Bromme D, Libby P, Tabas IA, Welch CL, Tall AR. Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K. Circ Res. 2009 Feb 27; 104(4):455-65. PMID: 19122179; PMCID: PMC2680702.
    View in: PubMed, PubMed Central
  54. Kawakami A, Osaka M, Aikawa M, Uematsu S, Akira S, Libby P, Shimokado K, Sacks FM, Yoshida M. Toll-like receptor 2 mediates apolipoprotein CIII-induced monocyte activation. Circ Res. 2008 Dec 05; 103(12):1402-9. PMID: 18974386; PMCID: PMC2994199.
    View in: PubMed, PubMed Central
  55. Minami M, Shimizu K, Okamoto Y, Folco E, Ilasaca ML, Feinberg MW, Aikawa M, Libby P. Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation. J Biol Chem. 2008 Apr 11; 283(15):9692-703. PMID: 18270204; PMCID: PMC2442287.
    View in: PubMed, PubMed Central
  56. Schneider F, Sukhova GK, Aikawa M, Canner J, Gerdes N, Tang SM, Shi GP, Apte SS, Libby P. Matrix-metalloproteinase-14 deficiency in bone-marrow-derived cells promotes collagen accumulation in mouse atherosclerotic plaques. Circulation. 2008 Feb 19; 117(7):931-9. PMID: 18250269.
    View in: PubMed
  57. Miyazaki T, Aikawa E, Aikawa M. Immunol Endocr Metab Agents in Med Chem. Biology of cholesterol lowering in atherosclerotic plaques. 2008; 8:105-115.
  58. Aikawa E, Nahrendorf M, Figueiredo JL, Swirski FK, Shtatland T, Kohler RH, Jaffer FA, Aikawa M, Weissleder R. Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo. Circulation. 2007 Dec 11; 116(24):2841-50. PMID: 18040026.
    View in: PubMed
  59. Aikawa M. The balance of power: the law of Yin and Yang in smooth muscle cell fate. Is YY1 a vascular protector? Circ Res. 2007 Jul 20; 101(2):111-3. PMID: 17641231.
    View in: PubMed
  60. Ahluwalia N, Lin AY, Tager AM, Pruitt IE, Anderson TJ, Kristo F, Shen D, Cruz AR, Aikawa M, Luster AD, Gerszten RE. Inhibited aortic aneurysm formation in BLT1-deficient mice. J Immunol. 2007 Jul 01; 179(1):691-7. PMID: 17579092.
    View in: PubMed
  61. Fung E, Tang SM, Canner JP, Morishige K, Arboleda-Velasquez JF, Cardoso AA, Carlesso N, Aster JC, Aikawa M. Delta-like 4 induces notch signaling in macrophages: implications for inflammation. Circulation. 2007 Jun 12; 115(23):2948-56. PMID: 17533181.
    View in: PubMed
  62. Zirlik A, Maier C, Gerdes N, MacFarlane L, Soosairajah J, Bavendiek U, Ahrens I, Ernst S, Bassler N, Missiou A, Patko Z, Aikawa M, Schönbeck U, Bode C, Libby P, Peter K. CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1. Circulation. 2007 Mar 27; 115(12):1571-80. PMID: 17372166.
    View in: PubMed
  63. Zirlik A, Bavendiek U, Libby P, MacFarlane L, Gerdes N, Jagielska J, Ernst S, Aikawa M, Nakano H, Tsitsikov E, Schönbeck U. TRAF-1, -2, -3, -5, and -6 are induced in atherosclerotic plaques and differentially mediate proinflammatory functions of CD40L in endothelial cells. Arterioscler Thromb Vasc Biol. 2007 May; 27(5):1101-7. PMID: 17332487.
    View in: PubMed
  64. Aikawa E, Nahrendorf M, Sosnovik D, Lok VM, Jaffer FA, Aikawa M, Weissleder R. Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease. Circulation. 2007 Jan 23; 115(3):377-86. PMID: 17224478.
    View in: PubMed
  65. Tsimikas S, Aikawa M, Miller FJ, Miller ER, Torzewski M, Lentz SR, Bergmark C, Heistad DD, Libby P, Witztum JL. Increased plasma oxidized phospholipid:apolipoprotein B-100 ratio with concomitant depletion of oxidized phospholipids from atherosclerotic lesions after dietary lipid-lowering: a potential biomarker of early atherosclerosis regression. Arterioscler Thromb Vasc Biol. 2007 Jan; 27(1):175-81. PMID: 17082490.
    View in: PubMed
  66. Kawakami A, Aikawa M, Nitta N, Yoshida M, Libby P, Sacks FM. Apolipoprotein CIII-induced THP-1 cell adhesion to endothelial cells involves pertussis toxin-sensitive G protein- and protein kinase C alpha-mediated nuclear factor-kappaB activation. Arterioscler Thromb Vasc Biol. 2007 Jan; 27(1):219-25. PMID: 17038637.
    View in: PubMed
  67. Kawakami A, Aikawa M, Alcaide P, Luscinskas FW, Libby P, Sacks FM. Apolipoprotein CIII induces expression of vascular cell adhesion molecule-1 in vascular endothelial cells and increases adhesion of monocytic cells. Circulation. 2006 Aug 15; 114(7):681-7. PMID: 16894036.
    View in: PubMed
  68. Deguchi JO, Aikawa M, Tung CH, Aikawa E, Kim DE, Ntziachristos V, Weissleder R, Libby P. Inflammation in atherosclerosis: visualizing matrix metalloproteinase action in macrophages in vivo. Circulation. 2006 Jul 04; 114(1):55-62. PMID: 16801460.
    View in: PubMed
  69. Aikawa E, Whittaker P, Farber M, Mendelson K, Padera RF, Aikawa M, Schoen FJ. Human semilunar cardiac valve remodeling by activated cells from fetus to adult: implications for postnatal adaptation, pathology, and tissue engineering. Circulation. 2006 Mar 14; 113(10):1344-52. PMID: 16534030.
    View in: PubMed
  70. Kawakami A, Aikawa M, Libby P, Alcaide P, Luscinskas FW, Sacks FM. Apolipoprotein CIII in apolipoprotein B lipoproteins enhances the adhesion of human monocytic cells to endothelial cells. Circulation. 2006 Feb 07; 113(5):691-700. PMID: 16461842.
    View in: PubMed
  71. Libby P, Aikawa M, Jain MK. Vascular endothelium and atherosclerosis. Handb Exp Pharmacol. 2006; (176 Pt 2):285-306. PMID: 16999230.
    View in: PubMed
  72. Sugiyama S, Kugiyama K, Nakamura S, Kataoka K, Aikawa M, Shimizu K, Koide S, Mitchell RN, Ogawa H, Libby P. Characterization of smooth muscle-like cells in circulating human peripheral blood. Atherosclerosis. 2006 Aug; 187(2):351-62. PMID: 16253262.
    View in: PubMed
  73. Deguchi JO, Aikawa E, Libby P, Vachon JR, Inada M, Krane SM, Whittaker P, Aikawa M. Matrix metalloproteinase-13/collagenase-3 deletion promotes collagen accumulation and organization in mouse atherosclerotic plaques. Circulation. 2005 Oct 25; 112(17):2708-15. PMID: 16230484.
    View in: PubMed
  74. Larose E, Yeghiazarians Y, Libby P, Yucel EK, Aikawa M, Kacher DF, Aikawa E, Kinlay S, Schoen FJ, Selwyn AP, Ganz P. Characterization of human atherosclerotic plaques by intravascular magnetic resonance imaging. Circulation. 2005 Oct 11; 112(15):2324-31. PMID: 16203910.
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  75. Arboleda-Velasquez JF, Rampal R, Fung E, Darland DC, Liu M, Martinez MC, Donahue CP, Navarro-Gonzalez MF, Libby P, D'Amore PA, Aikawa M, Haltiwanger RS, Kosik KS. CADASIL mutations impair Notch3 glycosylation by Fringe. Hum Mol Genet. 2005 Jun 15; 14(12):1631-9. PMID: 15857853.
    View in: PubMed
  76. Aikawa M, Libby P. Lipid lowering therapy in atherosclerosis. Semin Vasc Med. 2004 Nov; 4(4):357-66. PMID: 15861316.
    View in: PubMed
  77. Rabkin-Aikawa E, Aikawa M, Farber M, Kratz JR, Garcia-Cardena G, Kouchoukos NT, Mitchell MB, Jonas RA, Schoen FJ. Clinical pulmonary autograft valves: pathologic evidence of adaptive remodeling in the aortic site. J Thorac Cardiovasc Surg. 2004 Oct; 128(4):552-61. PMID: 15457156.
    View in: PubMed
  78. Fukumoto Y, Deguchi JO, Libby P, Rabkin-Aikawa E, Sakata Y, Chin MT, Hill CC, Lawler PR, Varo N, Schoen FJ, Krane SM, Aikawa M. Genetically determined resistance to collagenase action augments interstitial collagen accumulation in atherosclerotic plaques. Circulation. 2004 Oct 05; 110(14):1953-9. PMID: 15451791.
    View in: PubMed
  79. Rabkin-Aikawa E, Farber M, Aikawa M, Schoen FJ. Dynamic and reversible changes of interstitial cell phenotype during remodeling of cardiac valves. J Heart Valve Dis. 2004 Sep; 13(5):841-7. PMID: 15473488.
    View in: PubMed
  80. Aikawa M. Effects of statin therapy on vascular dysfunction. Coron Artery Dis. 2004 Aug; 15(5):227-33. PMID: 15238817.
    View in: PubMed
  81. Hosgor M, Karaca I, Ozer E, Erdag G, Ulukus C, Fescekoglu O, Aikawa M. The role of smooth muscle cell differentiation in the mechanism of obliteration of processus vaginalis. J Pediatr Surg. 2004 Jul; 39(7):1018-23. PMID: 15213890.
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  82. Sugiyama S, Kugiyama K, Aikawa M, Nakamura S, Ogawa H, Libby P. Hypochlorous acid, a macrophage product, induces endothelial apoptosis and tissue factor expression: involvement of myeloperoxidase-mediated oxidant in plaque erosion and thrombogenesis. Arterioscler Thromb Vasc Biol. 2004 Jul; 24(7):1309-14. PMID: 15142860.
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  83. Aikawa M, Libby P. The vulnerable atherosclerotic plaque: pathogenesis and therapeutic approach. Cardiovasc Pathol. 2004 May-Jun; 13(3):125-38. PMID: 15081469.
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  84. Aikawa M, Libby P. Atherosclerotic plaque inflammation: the final frontier? Can J Cardiol. 2004 May 01; 20(6):631-4. PMID: 15152295.
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  85. Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, Rumberger J, Badimon JJ, Stefanadis C, Moreno P, Pasterkamp G, Fayad Z, Stone PH, Waxman S, Raggi P, Madjid M, Zarrabi A, Burke A, Yuan C, Fitzgerald PJ, Siscovick DS, de Korte CL, Aikawa M, Airaksinen KE, Assmann G, Becker CR, Chesebro JH, Farb A, Galis ZS, Jackson C, Jang IK, Koenig W, Lodder RA, March K, Demirovic J, Navab M, Priori SG, Rekhter MD, Bahr R, Grundy SM, Mehran R, Colombo A, Boerwinkle E, Ballantyne C, Insull W, Schwartz RS, Vogel R, Serruys PW, Hansson GK, Faxon DP, Kaul S, Drexler H, Greenland P, Muller JE, Virmani R, Ridker PM, Zipes DP, Shah PK, Willerson JT. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part II. Circulation. 2003 Oct 14; 108(15):1772-8. PMID: 14557340.
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  86. Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, Rumberger J, Badimon JJ, Stefanadis C, Moreno P, Pasterkamp G, Fayad Z, Stone PH, Waxman S, Raggi P, Madjid M, Zarrabi A, Burke A, Yuan C, Fitzgerald PJ, Siscovick DS, de Korte CL, Aikawa M, Juhani Airaksinen KE, Assmann G, Becker CR, Chesebro JH, Farb A, Galis ZS, Jackson C, Jang IK, Koenig W, Lodder RA, March K, Demirovic J, Navab M, Priori SG, Rekhter MD, Bahr R, Grundy SM, Mehran R, Colombo A, Boerwinkle E, Ballantyne C, Insull W, Schwartz RS, Vogel R, Serruys PW, Hansson GK, Faxon DP, Kaul S, Drexler H, Greenland P, Muller JE, Virmani R, Ridker PM, Zipes DP, Shah PK, Willerson JT. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I. Circulation. 2003 Oct 07; 108(14):1664-72. PMID: 14530185.
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  87. Shimizu K, Aikawa M, Takayama K, Libby P, Mitchell RN. Direct anti-inflammatory mechanisms contribute to attenuation of experimental allograft arteriosclerosis by statins. Circulation. 2003 Oct 28; 108(17):2113-20. PMID: 14517172.
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  88. Lindsey ML, Yoshioka J, MacGillivray C, Muangman S, Gannon J, Verghese A, Aikawa M, Libby P, Krane SM, Lee RT. Effect of a cleavage-resistant collagen mutation on left ventricular remodeling. Circ Res. 2003 Aug 08; 93(3):238-45. PMID: 12855673.
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  89. Libby P, Aikawa M. Mechanisms of plaque stabilization with statins. Am J Cardiol. 2003 Feb 20; 91(4A):4B-8B. PMID: 12615292.
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  90. Libby P, Aikawa M. Effects of statins in reducing thrombotic risk and modulating plaque vulnerability. Clin Cardiol. 2003 Jan; 26(1 Suppl 1):I11-4. PMID: 12539817.
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  91. Libby P, Aikawa M. Stabilization of atherosclerotic plaques: new mechanisms and clinical targets. Nat Med. 2002 Nov; 8(11):1257-62. PMID: 12411953.
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  92. Aikawa M, Sugiyama S, Hill CC, Voglic SJ, Rabkin E, Fukumoto Y, Schoen FJ, Witztum JL, Libby P. Lipid lowering reduces oxidative stress and endothelial cell activation in rabbit atheroma. Circulation. 2002 Sep 10; 106(11):1390-6. PMID: 12221058.
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  93. Rabkin E, Hoerstrup SP, Aikawa M, Mayer JE, Schoen FJ. Evolution of cell phenotype and extracellular matrix in tissue-engineered heart valves during in-vitro maturation and in-vivo remodeling. J Heart Valve Dis. 2002 May; 11(3):308-14; discussion 314. PMID: 12056720.
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  94. Libby P, Aikawa M. Vitamin C, collagen, and cracks in the plaque. Circulation. 2002 Mar 26; 105(12):1396-8. PMID: 11914242.
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  95. Lindsey ML, Gannon J, Aikawa M, Schoen FJ, Rabkin E, Lopresti-Morrow L, Crawford J, Black S, Libby P, Mitchell PG, Lee RT. Selective matrix metalloproteinase inhibition reduces left ventricular remodeling but does not inhibit angiogenesis after myocardial infarction. Circulation. 2002 Feb 12; 105(6):753-8. PMID: 11839633.
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  96. Akaki M, Nagayasu E, Nakano Y, Aikawa M. Surface charge of Plasmodium falciparum merozoites as revealed by atomic force microscopy with surface potential spectroscopy. Parasitol Res. 2002 Jan; 88(1):16-20. PMID: 11822732.
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  97. Rabkin E, Aikawa M, Stone JR, Fukumoto Y, Libby P, Schoen FJ. Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valves. Circulation. 2001 Nov 20; 104(21):2525-32. PMID: 11714645.
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  98. Kikuchi M, Looareesuwan S, Ubalee R, Tasanor O, Suzuki F, Wattanagoon Y, Na-Bangchang K, Kimura A, Aikawa M, Hirayama K. Association of adhesion molecule PECAM-1/CD31 polymorphism with susceptibility to cerebral malaria in Thais. Parasitol Int. 2001 Nov; 50(4):235-9. PMID: 11719109.
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  99. Osaki T, Oyama T, Inoue M, Gu CD, Kodate M, Aikawa M, So T, Mizukami M, Mitsudomi T, Yasumoto K. Molecular biological markers and micrometastasis in resected non-small-cell lung cancer. Prognostic implications. Jpn J Thorac Cardiovasc Surg. 2001 Sep; 49(9):545-51. PMID: 11577444.
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  100. Osaki T, Oyama T, Takenoyama M, So T, Yamashita T, Aikawa M, Ono K, Yasumoto K. [Results of surgical treatment for primary lung cancer; time trends of survival and clinicopathologic features]. J UOEH. 2001 Sep 01; 23(3):277-83. PMID: 11570051.
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  101. Sakamoto H, Aikawa M, Hill CC, Weiss D, Taylor WR, Libby P, Lee RT. Biomechanical strain induces class a scavenger receptor expression in human monocyte/macrophages and THP-1 cells: a potential mechanism of increased atherosclerosis in hypertension. Circulation. 2001 Jul 03; 104(1):109-14. PMID: 11435347.
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  102. Shimizu K, Sugiyama S, Aikawa M, Fukumoto Y, Rabkin E, Libby P, Mitchell RN. Host bone-marrow cells are a source of donor intimal smooth- muscle-like cells in murine aortic transplant arteriopathy. Nat Med. 2001 Jun; 7(6):738-41. PMID: 11385513.
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  103. Libby P, Aikawa M. Evolution and stabilization of vulnerable atherosclerotic plaques. Jpn Circ J. 2001 Jun; 65(6):473-9. PMID: 11407724.
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  104. Zhang M, Hisaeda H, Kano S, Matsumoto Y, Hao YP, Looaresuwan S, Aikawa M, Himeno K. Antibodies specific for heat shock proteins in human and murine malaria. Microbes Infect. 2001 Apr; 3(5):363-7. PMID: 11369272.
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  105. Akaki M, Nakano Y, Nagayasu E, Nagakura K, Kawai S, Aikawa M. Invasive forms of Toxoplasma gondii, Leishmania amazonensis and Trypanosoma cruzi have a positive charge at their contact site with host cells. Parasitol Res. 2001 Mar; 87(3):193-7. PMID: 11293566.
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  106. Fukumoto Y, Libby P, Rabkin E, Hill CC, Enomoto M, Hirouchi Y, Shiomi M, Aikawa M. Statins alter smooth muscle cell accumulation and collagen content in established atheroma of watanabe heritable hyperlipidemic rabbits. Circulation. 2001 Feb 20; 103(7):993-9. PMID: 11181475.
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  107. Aikawa M, Rabkin E, Sugiyama S, Voglic SJ, Fukumoto Y, Furukawa Y, Shiomi M, Schoen FJ, Libby P. An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro. Circulation. 2001 Jan 16; 103(2):276-83. PMID: 11208689.
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  108. Nagayasu E, Ito M, Akaki M, Nakano Y, Kimura M, Looareesuwan S, Aikawa M. CR1 density polymorphism on erythrocytes of falciparum malaria patients in Thailand. Am J Trop Med Hyg. 2001 Jan-Feb; 64(1-2):1-5. PMID: 11425154.
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  109. Libby P, Aikawa M, Schönbeck U. Cholesterol and atherosclerosis. Biochim Biophys Acta. 2000 Dec 15; 1529(1-3):299-309. PMID: 11111097.
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  110. Ducharme A, Frantz S, Aikawa M, Rabkin E, Lindsey M, Rohde LE, Schoen FJ, Kelly RA, Werb Z, Libby P, Lee RT. Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction. J Clin Invest. 2000 Jul; 106(1):55-62. PMID: 10880048; PMCID: PMC517910.
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  111. Libby P, Aikawa M, Kinlay S, Selwyn A, Ganz P. Lipid lowering improves endothelial functions. Int J Cardiol. 2000 Jun 30; 74 Suppl 1:S3-S10. PMID: 10856767.
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  112. Aikawa M, Libby P. Lipid lowering reduces proteolytic and prothrombotic potential in rabbit atheroma. Ann N Y Acad Sci. 2000 May; 902:140-52. PMID: 10865834.
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  113. Ahmed K, Nakagawa T, Nakano Y, Martinez G, Ichinose A, Zheng CH, Akaki M, Aikawa M, Nagatake T. Attachment of Moraxella catarrhalis occurs to the positively charged domains of pharyngeal epithelial cells. Microb Pathog. 2000 Apr; 28(4):203-9. PMID: 10764611.
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  114. Perlmann P, Perlmann H, Looareesuwan S, Krudsood S, Kano S, Matsumoto Y, Brittenham G, Troye-Blomberg M, Aikawa M. Contrasting functions of IgG and IgE antimalarial antibodies in uncomplicated and severe Plasmodium falciparum malaria. Am J Trop Med Hyg. 2000 Mar; 62(3):373-7. PMID: 11037780.
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  115. Matsumoto J, Kawai S, Terao K, Kirinoki M, Yasutomi Y, Aikawa M, Matsuda H. Malaria infection induces rapid elevation of the soluble Fas ligand level in serum and subsequent T lymphocytopenia: possible factors responsible for the differences in susceptibility of two species of Macaca monkeys to Plasmodium coatneyi infection. Infect Immun. 2000 Mar; 68(3):1183-8. PMID: 10678924; PMCID: PMC97265.
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  116. Zhang K, Fujioka H, Lobo CA, Kitayaporn D, Aikawa M, Kumar N. Cloning and characterization of a new asparagine-rich protein in Plasmodium falciparum. Parasitol Res. 1999 Dec; 85(12):956-63. PMID: 10599917.
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  117. Shiojima I, Aikawa M, Suzuki J, Yazaki Y, Nagai R. Embryonic smooth muscle myosin heavy chain SMemb is expressed in pressure-overloaded cardiac fibroblasts. Jpn Heart J. 1999 Nov; 40(6):803-18. PMID: 10737564.
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  118. Wright M, Aikawa M, Szeto W, Papkoff J. Identification of a Wnt-responsive signal transduction pathway in primary endothelial cells. Biochem Biophys Res Commun. 1999 Sep 24; 263(2):384-8. PMID: 10491302.
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  119. Aikawa M, Voglic SJ, Sugiyama S, Rabkin E, Taubman MB, Fallon JT, Libby P. Dietary lipid lowering reduces tissue factor expression in rabbit atheroma. Circulation. 1999 Sep 14; 100(11):1215-22. PMID: 10484543.
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  120. Libby P, Mach F, Schönbeck U, Bourcier T, Aikawa M. Regulation of the thrombotic potential of atheroma. Thromb Haemost. 1999 Aug; 82(2):736-41. PMID: 10605776.
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  121. McConnell MV, Aikawa M, Maier SE, Ganz P, Libby P, Lee RT. MRI of rabbit atherosclerosis in response to dietary cholesterol lowering. Arterioscler Thromb Vasc Biol. 1999 Aug; 19(8):1956-9. PMID: 10446077.
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  122. Watanabe N, Kurabayashi M, Shimomura Y, Kawai-Kowase K, Hoshino Y, Manabe I, Watanabe M, Aikawa M, Kuro-o M, Suzuki T, Yazaki Y, Nagai R. BTEB2, a Krüppel-like transcription factor, regulates expression of the SMemb/Nonmuscle myosin heavy chain B (SMemb/NMHC-B) gene. Circ Res. 1999 Jul 23; 85(2):182-91. PMID: 10417400.
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  123. Rohde LE, Ducharme A, Arroyo LH, Aikawa M, Sukhova GH, Lopez-Anaya A, McClure KF, Mitchell PG, Libby P, Lee RT. Matrix metalloproteinase inhibition attenuates early left ventricular enlargement after experimental myocardial infarction in mice. Circulation. 1999 Jun 15; 99(23):3063-70. PMID: 10368126.
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  124. Lobo CA, Fujioka H, Aikawa M, Kumar N. Disruption of the Pfg27 locus by homologous recombination leads to loss of the sexual phenotype in P. falciparum. Mol Cell. 1999 Jun; 3(6):793-8. PMID: 10394367.
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  125. Rohde LE, Aikawa M, Cheng GC, Sukhova G, Solomon SD, Libby P, Pfeffer J, Pfeffer MA, Lee RT. Echocardiography-derived left ventricular end-systolic regional wall stress and matrix remodeling after experimental myocardial infarction. J Am Coll Cardiol. 1999 Mar; 33(3):835-42. PMID: 10080489.
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  126. Aikawa M, Rabkin E, Voglic SJ, Shing H, Nagai R, Schoen FJ, Libby P. Lipid lowering promotes accumulation of mature smooth muscle cells expressing smooth muscle myosin heavy chain isoforms in rabbit atheroma. Circ Res. 1998 Nov 16; 83(10):1015-26. PMID: 9815149.
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  127. Blackman MJ, Fujioka H, Stafford WH, Sajid M, Clough B, Fleck SL, Aikawa M, Grainger M, Hackett F. A subtilisin-like protein in secretory organelles of Plasmodium falciparum merozoites. J Biol Chem. 1998 Sep 04; 273(36):23398-409. PMID: 9722575.
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  128. Katakura K, Kawazu S, Naya T, Nagakura K, Ito M, Aikawa M, Qu JQ, Guan LR, Zuo XP, Chai JJ, Chang KP, Matsumoto Y. Diagnosis of kala-azar by nested PCR based on amplification of the Leishmania mini-exon gene. J Clin Microbiol. 1998 Aug; 36(8):2173-7. PMID: 9665985; PMCID: PMC104997.
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  129. Takazawa K, Tanaka N, Fujita M, Matsuoka O, Saiki T, Aikawa M, Tamura S, Ibukiyama C. Assessment of vasoactive agents and vascular aging by the second derivative of photoplethysmogram waveform. Hypertension. 1998 Aug; 32(2):365-70. PMID: 9719069.
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  130. Miyauchi K, Aikawa M, Tani T, Nakahara K, Kawai S, Nagai R, Okada R, Yamaguchi H. Effect of probucol on smooth muscle cell proliferation and dedifferentiation after vascular injury in rabbits: possible role of PDGF. Cardiovasc Drugs Ther. 1998 Jul; 12(3):251-60. PMID: 9784904.
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  131. Papkoff J, Aikawa M. WNT-1 and HGF regulate GSK3 beta activity and beta-catenin signaling in mammary epithelial cells. Biochem Biophys Res Commun. 1998 Jun 29; 247(3):851-8. PMID: 9647782.
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  132. Aikawa M, Rabkin E, Okada Y, Voglic SJ, Clinton SK, Brinckerhoff CE, Sukhova GK, Libby P. Lipid lowering by diet reduces matrix metalloproteinase activity and increases collagen content of rabbit atheroma: a potential mechanism of lesion stabilization. Circulation. 1998 Jun 23; 97(24):2433-44. PMID: 9641696.
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  133. Libby P, Aikawa M. New insights into plaque stabilisation by lipid lowering. Drugs. 1998; 56 Suppl 1:9-13; discussion 33. PMID: 9740536.
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  134. Manabe I, Kurabayashi M, Shimomura Y, Kuro-o M, Watanabe N, Watanabe M, Aikawa M, Suzuki T, Yazaki Y, Nagai R. Isolation of the embryonic form of smooth muscle myosin heavy chain (SMemb/NMHC-B) gene and characterization of its 5'-flanking region. Biochem Biophys Res Commun. 1997 Oct 20; 239(2):598-605. PMID: 9344877.
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  135. Jakobsen PH, Bygbjerg IC, Theander TG, Hviid L, Fujioka H, Aikawa M, Bayoumi RA, Koch C. Soluble haemoglobin is a marker of recent Plasmodium falciparum infections. Immunol Lett. 1997 Oct; 59(1):35-42. PMID: 9334855.
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  136. Aikawa M, Sakomura Y, Ueda M, Kimura K, Manabe I, Ishiwata S, Komiyama N, Yamaguchi H, Yazaki Y, Nagai R. Redifferentiation of smooth muscle cells after coronary angioplasty determined via myosin heavy chain expression. Circulation. 1997 Jul 01; 96(1):82-90. PMID: 9236421.
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  137. Okazaki T, Sharma HS, Aikawa M, Yamataka A, Nagai R, Miyano T, Tibboel D. Pulmonary expression of vascular endothelial growth factor and myosin isoforms in rats with congenital diaphragmatic hernia. J Pediatr Surg. 1997 Mar; 32(3):391-4. PMID: 9094000.
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  138. Fukumoto Y, Shimokawa H, Ito A, Kadokami T, Yonemitsu Y, Aikawa M, Owada MK, Egashira K, Sueishi K, Nagai R, Yazaki Y, Takeshita A. Inflammatory cytokines cause coronary arteriosclerosis-like changes and alterations in the smooth-muscle phenotypes in pigs. J Cardiovasc Pharmacol. 1997 Feb; 29(2):222-31. PMID: 9057072.
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  139. Ueda S, Aikawa M, Kawata M, Naruse I, Whitaker-Azmitia PM, Azmitia EC. Neuro-glial neurotrophic interaction in the S-100 beta retarded mutant mouse (Polydactyly Nagoya). III. Transplantation study. Brain Res. 1996 Oct 28; 738(1):15-23. PMID: 8949922.
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  140. Smith CD, Brown AE, Nakazawa S, Fujioka H, Aikawa M. Multi-organ erythrocyte sequestration and ligand expression in rhesus monkeys infected with Plasmodium coatneyi malaria. Am J Trop Med Hyg. 1996 Oct; 55(4):379-83. PMID: 8916792.
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  141. Libby P, Geng YJ, Aikawa M, Schoenbeck U, Mach F, Clinton SK, Sukhova GK, Lee RT. Macrophages and atherosclerotic plaque stability. Curr Opin Lipidol. 1996 Oct; 7(5):330-5. PMID: 8937525.
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  142. Suzuki J, Isobe M, Aikawa M, Kawauchi M, Shiojima I, Kobayashi N, Tojo A, Suzuki T, Kimura K, Nishikawa T, Sakai T, Sekiguchi M, Yazaki Y, Nagai R. Nonmuscle and smooth muscle myosin heavy chain expression in rejected cardiac allografts. A study in rat and monkey models. Circulation. 1996 Sep 01; 94(5):1118-24. PMID: 8790054.
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  143. Watanabe M, Sakomura Y, Kurabayashi M, Manabe I, Aikawa M, Kuro-o M, Suzuki T, Yazaki Y, Nagai R. Structure and characterization of the 5'-flanking region of the mouse smooth muscle myosin heavy chain (SM1/2) gene. Circ Res. 1996 Jun; 78(6):978-89. PMID: 8635248.
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  144. Klotz FW, Cohen SJ, Szarfman A, Aikawa M, Howard RJ. Cross-reactive epitope among proteins in Plasmodium falciparum Maurer's clefts and primate leukocytes and platelets. Am J Trop Med Hyg. 1996 Jun; 54(6):655-9. PMID: 8686788.
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  145. Kuzuhara K, Dobashi Y, Aikawa M, Nishimori H, Inoue S, Otsubo O, Inou T, Mimura N, Komiyama N, Nakanishi M, Matuta H, Murata H. Evaluation of cardiac function of renal transplant patients using stress and rest cardiac pool gated scintigraphy and myocardial scintigraphy with 99mTc-MIBI. Transplant Proc. 1996 Jun; 28(3):1618-20. PMID: 8658810.
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  146. Hiroi J, Kimura K, Aikawa M, Tojo A, Suzuki Y, Nagamatsu T, Omata M, Yazaki Y, Nagai R. Expression of a nonmuscle myosin heavy chain in glomerular cells differentiates various types of glomerular disease in rats. Kidney Int. 1996 May; 49(5):1231-41. PMID: 8731086.
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  147. Bottius E, BenMohamed L, Brahimi K, Gras H, Lepers JP, Raharimalala L, Aikawa M, Meis J, Slierendregt B, Tartar A, Thomas A, Druilhe P. A novel Plasmodium falciparum sporozoite and liver stage antigen (SALSA) defines major B, T helper, and CTL epitopes. J Immunol. 1996 Apr 15; 156(8):2874-84. PMID: 8609407.
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  148. Suzuki T, Kim HS, Kurabayashi M, Hamada H, Fujii H, Aikawa M, Watanabe M, Watanabe N, Sakomura Y, Yazaki Y, Nagai R. Preferential differentiation of P19 mouse embryonal carcinoma cells into smooth muscle cells. Use of retinoic acid and antisense against the central nervous system-specific POU transcription factor Brn-2. Circ Res. 1996 Mar; 78(3):395-404. PMID: 8593698.
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  149. Fujioka H, Aikawa M. The molecular basis of pathogenesis of cerebral malaria. Microb Pathog. 1996 Feb; 20(2):63-72. PMID: 8722095.
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  150. Suzuki T, Aikawa M, Kuro-o M, Watanabe M, Kimura K, Yazaki Y, Nagai R. Presence of contractile-type smooth muscle cells in the endocardium. Cardiology. 1996 Jan-Feb; 87(1):23-7. PMID: 8631040.
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  151. Okamoto E, Suzuki T, Aikawa M, Imataka K, Fujii J, Kuro-o M, Nakahara K, Hasegawa A, Yazaki Y, Nagai R. Diversity of the synthetic-state smooth-muscle cells proliferating in mechanically and hemodynamically injured rabbit arteries. Lab Invest. 1996 Jan; 74(1):120-8. PMID: 8569174.
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  152. Wahlgren M, Abrams JS, Fernandez V, Bejarano MT, Azuma M, Torii M, Aikawa M, Howard RJ. Adhesion of Plasmodium falciparum-infected erythrocytes to human cells and secretion of cytokines (IL-1-beta, IL-1RA, IL-6, IL-8, IL-10, TGF beta, TNF alpha, G-CSF, GM-CSF. Scand J Immunol. 1995 Dec; 42(6):626-36. PMID: 8552986.
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  155. Nakamura T, Kimura K, Ebihara I, Takahashi T, Tomino Y, Aikawa M, Yazaki Y, Nagai R, Koide H. Glomerular expression of smooth-muscle myosin heavy-chain isoforms in aminonucleoside nephrosis in rats. Clin Sci (Lond). 1995 Jul; 89(1):45-52. PMID: 7671567.
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  159. Takewaki S, Kuro-o M, Hiroi Y, Yamazaki T, Noguchi T, Miyagishi A, Nakahara K, Aikawa M, Manabe I, Yazaki Y, et al. Activation of Na(+)-H+ antiporter (NHE-1) gene expression during growth, hypertrophy and proliferation of the rabbit cardiovascular system. J Mol Cell Cardiol. 1995 Jan; 27(1):729-42. PMID: 7760389.
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  161. Maeno Y, Fujioka H, Hollingdale MR, Ockenhouse CF, Nakazawa S, Aikawa M. Ultrastructural localization of CD36 in human hepatic sinusoidal lining cells, hepatocytes, human hepatoma (HepG2-A16) cells, and C32 amelanotic melanoma cells. Exp Parasitol. 1994 Nov; 79(3):383-90. PMID: 7525338.
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  162. Nakazawa S, Brown AE, Maeno Y, Smith CD, Aikawa M. Malaria-induced increase of splenic gamma delta T cells in humans, monkeys, and mice. Exp Parasitol. 1994 Nov; 79(3):391-8. PMID: 7957758.
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  163. Nagasawa H, Hisaeda H, Maekawa Y, Fujioka H, Ito Y, Aikawa M, Himeno K. gamma delta T cells play a crucial role in the expression of 65,000 MW heat-shock protein in mice immunized with Toxoplasma antigen. Immunology. 1994 Nov; 83(3):347-52. PMID: 7835958; PMCID: PMC1415035.
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  165. Fujioka H, Millet P, Maeno Y, Nakazawa S, Ito Y, Howard RJ, Collins WE, Aikawa M. A nonhuman primate model for human cerebral malaria: rhesus monkeys experimentally infected with Plasmodium fragile. Exp Parasitol. 1994 Jun; 78(4):371-6. PMID: 7515825.
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  166. Aikawa M, Sivam PN, Kuro-o M, Kimura K, Nakahara K, Takewaki S, Ueda M, Yamaguchi H, Yazaki Y, Periasamy M, et al. Human smooth muscle myosin heavy chain isoforms as molecular markers for vascular development and atherosclerosis. Circ Res. 1993 Dec; 73(6):1000-12. PMID: 7916668.
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  167. Kim HS, Aikawa M, Kimura K, Kuro-o M, Nakahara K, Suzuki T, Katoh H, Okamoto E, Yazaki Y, Nagai R. Ductus arteriosus. Advanced differentiation of smooth muscle cells demonstrated by myosin heavy chain isoform expression in rabbits. Circulation. 1993 Oct; 88(4 Pt 1):1804-10. PMID: 8403325.
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  168. Yuki N, Yanagisawa K, Saito Y, Aikawa M, Miyatake T. [Proximal lower motor neuron syndrome associated with serum antibodies to asialo-GM1, GM1 and LM1]. Rinsho Shinkeigaku. 1993 Aug; 33(8):891-4. PMID: 8261703.
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  169. Kawai S, Aikawa M, Kano S, Suzuki M. A primate model for severe human malaria with cerebral involvement: Plasmodium coatneyi-infected Macaca fuscata. Am J Trop Med Hyg. 1993 May; 48(5):630-6. PMID: 8517481.
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  170. Millet P, Campbell GH, Sulzer AJ, Grady KK, Pohl J, Aikawa M, Collins WE. Immunogenicity of the Plasmodium falciparum asexual blood-stage synthetic peptide vaccine SPf66. Am J Trop Med Hyg. 1993 Mar; 48(3):424-31. PMID: 7682382.
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  171. Kumar N, Nagasawa H, Sacci JB, Sina BJ, Aikawa M, Atkinson C, Uparanukraw P, Kubiak LB, Azad AF, Hollingdale MR. Expression of members of the heat-shock protein 70 family in the exoerythrocytic stages of Plasmodium berghei and Plasmodium falciparum. Parasitol Res. 1993; 79(2):109-13. PMID: 8475027.
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  172. Rogers WO, Malik A, Mellouk S, Nakamura K, Rogers MD, Szarfman A, Gordon DM, Nussler AK, Aikawa M, Hoffman SL. Characterization of Plasmodium falciparum sporozoite surface protein 2. Proc Natl Acad Sci U S A. 1992 Oct 01; 89(19):9176-80. PMID: 1409621; PMCID: PMC50088.
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  173. Ockenhouse CF, Tegoshi T, Maeno Y, Benjamin C, Ho M, Kan KE, Thway Y, Win K, Aikawa M, Lobb RR. Human vascular endothelial cell adhesion receptors for Plasmodium falciparum-infected erythrocytes: roles for endothelial leukocyte adhesion molecule 1 and vascular cell adhesion molecule 1. J Exp Med. 1992 Oct 01; 176(4):1183-9. PMID: 1383378; PMCID: PMC2119387.
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  174. Nakamura K, Hasler T, Morehead K, Howard RJ, Aikawa M. Plasmodium falciparum-infected erythrocyte receptor(s) for CD36 and thrombospondin are restricted to knobs on the erythrocyte surface. J Histochem Cytochem. 1992 Sep; 40(9):1419-22. PMID: 1380530.
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  175. Aikawa M, Brown A, Smith CD, Tegoshi T, Howard RJ, Hasler TH, Ito Y, Perry G, Collins WE, Webster K. A primate model for human cerebral malaria: Plasmodium coatneyi-infected rhesus monkeys. Am J Trop Med Hyg. 1992 Apr; 46(4):391-7. PMID: 1374220.
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  176. Aikawa M, Brown AE, Smith CD, Tegoshi T, Howard RJ, Hasler TH, Ito Y, Collins WE, Webster HK. Plasmodium coatneyi-infected rhesus monkeys: a primate model for human cerebral malaria. Mem Inst Oswaldo Cruz. 1992; 87 Suppl 3:443-7. PMID: 1343725.
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  177. Verma JN, Wassef NM, Wirtz RA, Atkinson CT, Aikawa M, Loomis LD, Alving CR. Phagocytosis of liposomes by macrophages: intracellular fate of liposomal malaria antigen. Biochim Biophys Acta. 1991 Jul 22; 1066(2):229-38. PMID: 1854787.
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  178. Prioli RP, Mejia JS, Aji T, Aikawa M, Pereira ME. Trypanosoma cruzi: localization of neuraminidase on the surface of trypomastigotes. Trop Med Parasitol. 1991 Jun; 42(2):146-50. PMID: 1896773.
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  179. Riganti M, Pongponratn E, Tegoshi T, Looareesuwan S, Punpoowong B, Aikawa M. Human cerebral malaria in Thailand: a clinico-pathological correlation. Immunol Lett. 1990 Aug; 25(1-3):199-205. PMID: 2283150.
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  180. Barnwell JW, Asch AS, Nachman RL, Yamaya M, Aikawa M, Ingravallo P. A human 88-kD membrane glycoprotein (CD36) functions in vitro as a receptor for a cytoadherence ligand on Plasmodium falciparum-infected erythrocytes. J Clin Invest. 1989 Sep; 84(3):765-72. PMID: 2474574; PMCID: PMC329717.
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  181. Udomsangpetch R, Carlsson J, Wåhlin B, Holmquist G, Ozaki LS, Scherf A, Mattei D, Mercereau-Puijalon O, Uni S, Aikawa M, et al. Reactivity of the human monoclonal antibody 33G2 with repeated sequences of three distinct Plasmodium falciparum antigens. J Immunol. 1989 May 15; 142(10):3620-6. PMID: 2654292.
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  182. Rosenthal PJ, McKerrow JH, Aikawa M, Nagasawa H, Leech JH. A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum. J Clin Invest. 1988 Nov; 82(5):1560-6. PMID: 3053784; PMCID: PMC442723.
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  183. Aikawa M. Human cerebral malaria. Am J Trop Med Hyg. 1988 Jul; 39(1):3-10. PMID: 3041856.
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  184. Udagama PV, Atkinson CT, Peiris JS, David PH, Mendis KN, Aikawa M. Immunoelectron microscopy of Schüffner's dots in Plasmodium vivax-infected human erythrocytes. Am J Pathol. 1988 Apr; 131(1):48-52. PMID: 3281470; PMCID: PMC1880566.
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  185. Chulay JD, Lyon JA, Haynes JD, Meierovics AI, Atkinson CT, Aikawa M. Monoclonal antibody characterization of Plasmodium falciparum antigens in immune complexes formed when schizonts rupture in the presence of immune serum. J Immunol. 1987 Oct 15; 139(8):2768-74. PMID: 3309058.
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  186. Scheibel LW, Colombani PM, Hess AD, Aikawa M, Atkinson CT, Milhous WK. Calcium and calmodulin antagonists inhibit human malaria parasites (Plasmodium falciparum): implications for drug design. Proc Natl Acad Sci U S A. 1987 Oct; 84(20):7310-4. PMID: 3313391; PMCID: PMC299282.
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  187. Kazura JW, de Brito P, Rabbege J, Aikawa M. Role of granulocyte oxygen products in damage of Schistosoma mansoni eggs in vitro. J Clin Invest. 1985 Apr; 75(4):1297-307. PMID: 2985656; PMCID: PMC425459.
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  188. Kaplan BS, Uni S, Aikawa M, Mahmoud AA. Effector mechanism of host resistance in murine giardiasis: specific IgG and IgA cell-mediated toxicity. J Immunol. 1985 Mar; 134(3):1975-81. PMID: 3968437.
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  189. Abramowsky CR, Aikawa M, Swinehart GL, Snajdar RM. Spontaneous nephrotic syndrome in a genetic rat model. Am J Pathol. 1984 Dec; 117(3):400-8. PMID: 6507587; PMCID: PMC1900576.
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  190. Miller LH, David PH, Hudson DE, Hadley TJ, Richards RL, Aikawa M. Monoclonal antibodies to a 140,000-m.w. protein on Plasmodium knowlesi merozoites inhibit their invasion of rhesus erythrocytes. J Immunol. 1984 Jan; 132(1):438-42. PMID: 6690607.
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  191. Greenblatt HC, Diggs CL, Aikawa M. Antibody-dependent phagocytosis of Trypanosoma rhodesiense by murine macrophages. Am J Trop Med Hyg. 1983 Jan; 32(1):34-45. PMID: 6824126.
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  192. El-Sadr WM, Aikawa M, Greene BM. In vitro immune mechanisms associated with clearance of microfilariae of Dirofilaria immitis. J Immunol. 1983 Jan; 130(1):428-34. PMID: 6847891.
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  193. Schmidt JA, Udeinya IJ, Leech JH, Hay RJ, Aikawa M, Barnwell J, Green I, Miller LH. Plasmodium falciparum malaria. An amelanotic melanoma cell line bears receptors for the knob ligand on infected erythrocytes. J Clin Invest. 1982 Aug; 70(2):379-86. PMID: 7047567; PMCID: PMC371246.
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  194. Aikawa M, Hendricks LD, Ito Y, Jagusiak M. Interactions between macrophagelike cells and Leishmania braziliensis in vitro. Am J Pathol. 1982 Jul; 108(1):50-9. PMID: 7091302; PMCID: PMC1916017.
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  195. Butler T, Spagnuolo PJ, Goldsmith GH, Aikawa M. Interaction of Borrelia spirochetes with human mononuclear leukocytes causes production of leukocytic pyrogen and thromboplastin. J Lab Clin Med. 1982 May; 99(5):709-21. PMID: 7069269.
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  196. Greene BM, Taylor HR, Aikawa M. Cellular killing of microfilariae of Onchocerca volvulus: eosinophil and neutrophil-mediated immune serum-dependent destruction. J Immunol. 1981 Oct; 127(4):1611-8. PMID: 7276574.
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  197. Epstein N, Miller LH, Kaushel DC, Udeinya IJ, Rener J, Howard RJ, Asofsky R, Aikawa M, Hess RL. Monoclonal antibodies against a specific surface determinant on malarial (Plasmodium knowlesi) merozoites block erythrocyte invasion. J Immunol. 1981 Jul; 127(1):212-7. PMID: 6165764.
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  198. Abramowsky CR, Powers KG, Aikawa M, Swinehart G. Dirofilaria immitis. 5. Immunopathology of filarial nephropathy in dogs. Am J Pathol. 1981 Jul; 104(1):1-12. PMID: 7020425; PMCID: PMC1903733.
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  199. Aikawa M, Yoshida N, Nussenzweig RS, Nussenzweig V. The protective antigen of malarial sporozoites (Plasmodium berghei) is a differentiation antigen. J Immunol. 1981 Jun; 126(6):2494-5. PMID: 6785357.
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  200. Kazura JW, Aikawa M. Host defense mechanisms against Trichinella spiralis infection in the mouse: eosinophil-mediated destruction of newborn larvae in vitro. J Immunol. 1980 Jan; 124(1):355-61. PMID: 7350232.
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  201. Makker SP, Aikawa M. Mesangial glomerulonephropathy with deposition of IgG, IgM, and C3 induced by mercuric chloride: a new model. Lab Invest. 1979 Jul; 41(1):45-50. PMID: 376939.
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  202. Aikawa M, Komata Y, Asai T, Midorikawa O. Transmission and scanning electron microscopy of host cell entry by Toxoplasma gondii. Am J Pathol. 1977 May; 87(2):285-96. PMID: 851168; PMCID: PMC2032037.
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  203. Cochrane AH, Aikawa M, Jeng M, Nussenzweig RS. Antibody-induced ultrastructural changes of malarial sporozoites. J Immunol. 1976 Mar; 116(3):859-67. PMID: 815435.
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  204. Aikawa M, Miller LH, Rabbege J. Caveola--vesicle complexes in the plasmalemma of erythrocytes infected by Plasmodium vivax and P cynomolgi. Unique structures related to Schüffner's dots. Am J Pathol. 1975 May; 79(2):285-300. PMID: 50017; PMCID: PMC1912656.
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  205. Miller LH, Aikawa M, Dvorak JA. Malaria (Plasmodium knowlesi) merozoites: immunity and the surface coat. J Immunol. 1975 Apr; 114(4):1237-42. PMID: 1117140.
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  206. Aikawa M. High-resolution autoradiography of malarial parasites treated with 3 H-chloroquine. Am J Pathol. 1972 May; 67(2):277-84. PMID: 5021103; PMCID: PMC2032601.
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  207. Aikawa M, Schoenbechler MJ, Barbaro JF, Sadun EH. Interaction of rabbit platelets and leukocytes in the release of histamine. Electron microscopic observations. Am J Pathol. 1971 Apr; 63(1):85-98. PMID: 4101057; PMCID: PMC2047462.
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  208. Aikawa M, Sprinz H. Erythrophagocytosis in the bone marrow of canary infected with malaria. Electron microscope observations. Lab Invest. 1971 Jan; 24(1):45-54. PMID: 5544827.
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  209. Aikawa M, Koletsky S. Arteriosclerosis of the mesenteric arteries of rats with renal hypertension. Electron microscopic observations. Am J Pathol. 1970 Dec; 61(3):293-322. PMID: 5526230; PMCID: PMC2047453.
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  210. Yata J, Aikawa M, Ohmi K, Yanagisawa M, Furukawa T. Neuroblastoma, clinical study of 55 cases. Paediatr Univ Tokyo. 1966 Dec; 13:34-42. PMID: 5979954.
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