Harvard Catalyst Profiles

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Masanori Aikawa, Ph.D., M.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01HL149302 (AIKAWA, MASANORI) Jul 15, 2019 - Jun 30, 2023
    NIH
    Pro-inflammatory activation of human macrophages regulated by lncRNAs
    Role: Principal Investigator
  2. R13HL142296 (AIKAWA, MASANORI) Oct 1, 2018 - Sep 30, 2019
    NIH
    NAVBO Workshops at Vascular Biology 2018
    Role: Principal Investigator
  3. R01HL126901 (AIKAWA, MASANORI) Jan 1, 2016 - Dec 31, 2019
    NIH
    PARP9 and PARP14 in atherosclerosis
    Role: Principal Investigator
  4. R01HL107550 (AIKAWA, MASANORI) Jan 1, 2012 - Nov 30, 2015
    NIH
    Dll4 in macrophage activation
    Role: Principal Investigator
  5. R01HL066086 (AIKAWA, MASANORI) Apr 3, 2003 - Mar 31, 2007
    NIH
    Role of the CD40/CD40L dyad in atherosclerosis
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Krohn JB, Aikawa E, Aikawa M, Hutcheson JD, Sahoo S, Fish JE. Editorial: Extracellular vesicles in cardiovascular inflammation and calcification. Front Cardiovasc Med. 2022; 9:1077124. PMID: 36426218; PMCID: PMC9680153.
    Citations:    
  2. Katsuki S, K Jha P, Lupieri A, Nakano T, Passos LSA, Rogers MA, Becker-Greene D, Le TD, Decano JL, Ho Lee L, Guimaraes GC, Abdelhamid I, Halu A, Muscoloni A, V Cannistraci C, Higashi H, Zhang H, Vromman A, Libby P, Keith Ozaki C, Sharma A, Singh SA, Aikawa E, Aikawa M. Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Promotes Macrophage Activation via LDL Receptor-Independent Mechanisms. Circ Res. 2022 Nov 11; 131(11):873-889. PMID: 36263780.
    Citations: 2     Fields:    Translation:Animals
  3. Kuo A, Checa A, Niaudet C, Jung B, Fu Z, Wheelock CE, Singh SA, Aikawa M, Smith LE, Proia RL, Hla T. Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis. Elife. 2022 10 05; 11. PMID: 36197001; PMCID: PMC9578713.
    Citations:    Fields:    Translation:AnimalsCells
  4. Morgan S, Lee LH, Halu A, Nicolau JS, Higashi H, Ha AH, Wen JR, Daugherty A, Libby P, Cameron SJ, Mix D, Aikawa E, Owens AP, Singh SA, Aikawa M. Identifying novel mechanisms of abdominal aortic aneurysm via unbiased proteomics and systems biology. Front Cardiovasc Med. 2022; 9:889994. PMID: 35990960; PMCID: PMC9382335.
    Citations:    
  5. Uchida S, Yu J, Goldman M, Asmis R, Yang X, Aikawa E, Bourantas C, Aikawa M, Tevaearai Stahel H. Editorial: Research reproducibility and preventing fraud. Front Cardiovasc Med. 2022; 9:979467. PMID: 35979020; PMCID: PMC9376614.
    Citations:    
  6. Atkins SK, Sonawane AR, Brouwhuis R, Barrientos J, Ha A, Rogers M, Tanaka T, Okui T, Kuraoka S, Singh SA, Aikawa M, Aikawa E. Induced pluripotent stem cell-derived smooth muscle cells to study cardiovascular calcification. Front Cardiovasc Med. 2022; 9:925777. PMID: 35958427.
    Citations:    
  7. Bartoli-Leonard F, Turner ME, Zimmer J, Chapurlat R, Pham T, Aikawa M, Pradhan AD, Szulc P, Aikawa E. Elevated lipoprotein(a) as a predictor for coronary events in older men. J Lipid Res. 2022 08; 63(8):100242. PMID: 35724702; PMCID: PMC9304778.
    Citations:    Fields:    
  8. Wang L, Xu GE, Pan L, Aikawa E, Aikawa M, Xiao J, Huang NF. Editorial: Frontiers in Cardiovascular Medicine: Rising Stars 2021. Front Cardiovasc Med. 2022; 9:928981. PMID: 35757336; PMCID: PMC9218798.
    Citations:    
  9. Decano JL, Aikawa M, Singh SA. Promise of a Novel Bedside-to-Bench Paradigm: Can Percutaneous Coronary Intervention Proteomics Balloon Into Clinical Practice? Arterioscler Thromb Vasc Biol. 2022 07; 42(7):865-867. PMID: 35616034.
    Citations:    Fields:    Translation:Humans
  10. Sonawane AR, Aikawa E, Aikawa M. Connections for Matters of the Heart: Network Medicine in Cardiovascular Diseases. Front Cardiovasc Med. 2022; 9:873582. PMID: 35665246; PMCID: PMC9160390.
    Citations:    
  11. Garelnabi M, Cowdin M, Fang Y, Shrestha B, Ushio-Fukai M, Aikawa E, Graham G, Molema G, Yanagisawa H, Aikawa M. Embracing Diversity, Equity, and Inclusion in the Scientific Community-Viewpoints of the Diversity, Equity, and Inclusion Committee of the North American Vascular Biology Organization. Front Cardiovasc Med. 2022; 9:863256. PMID: 35463765; PMCID: PMC9021758.
    Citations:    
  12. Decano JL, Iwamoto Y, Goto S, Lee JY, Matamalas JT, Halu A, Blaser M, Lee LH, Pieper B, Chelvanambi S, Silva-Nicolau J, Bartoli-Leonard F, Higashi H, Shibata H, Vyas P, Wang J, Gostjeva E, Body SC, Singh SA, Aikawa M, Aikawa E. A disease-driver population within interstitial cells of human calcific aortic valves identified via single-cell and proteomic profiling. Cell Rep. 2022 04 12; 39(2):110685. PMID: 35417712.
    Citations:    Fields:    Translation:HumansAnimalsCells
  13. Singh SA, Kuraoka S, Pestana DVS, Nasir W, Delanghe B, Aikawa M. The RiboMaP Spectral Annotation Method Applied to Various ADP-Ribosylome Studies Including INF-?-Stimulated Human Cells and Mouse Tissues. Front Cardiovasc Med. 2022; 9:851351. PMID: 35419443; PMCID: PMC8996112.
    Citations:    
  14. Asano T, Chelvanambi S, Decano JL, Whelan MC, Aikawa E, Aikawa M. In silico Drug Screening Approach Using L1000-Based Connectivity Map and Its Application to COVID-19. Front Cardiovasc Med. 2022; 9:842641. PMID: 35402570; PMCID: PMC8989014.
    Citations:    
  15. Passos LSA, Jha PK, Becker-Greene D, Blaser MC, Romero D, Lupieri A, Sukhova GK, Libby P, Singh SA, Dutra WO, Aikawa M, Levine RA, Nunes MCP, Aikawa E. Prothymosin Alpha: A Novel Contributor to Estradiol Receptor Alpha-Mediated CD8+ T-Cell Pathogenic Responses and Recognition of Type 1 Collagen in Rheumatic Heart Valve Disease. Circulation. 2022 02 15; 145(7):531-548. PMID: 35157519; PMCID: PMC8869797.
    Citations: 2     Fields:    Translation:HumansCells
  16. Sawada H, Katsumata Y, Higashi H, Zhang C, Li Y, Morgan S, Lee LH, Singh SA, Chen JZ, Franklin MK, Moorleghen JJ, Howatt DA, Rateri DL, Shen YH, LeMaire SA, Aikawa M, Majesky MW, Lu HS, Daugherty A. Second Heart Field-Derived Cells Contribute to Angiotensin II-Mediated Ascending Aortopathies. Circulation. 2022 03 29; 145(13):987-1001. PMID: 35143327; PMCID: PMC9008740.
    Citations: 1     Fields:    Translation:HumansAnimals
  17. Rogers MA, Atkins SK, Zheng KH, Singh SA, Chelvanambi S, Pham TH, Kuraoka S, Stroes ESG, Aikawa M, Aikawa E. Lipoprotein(a) Induces Vesicular Cardiovascular Calcification Revealed With Single-Extracellular Vesicle Analysis. Front Cardiovasc Med. 2022; 9:778919. PMID: 35155626; PMCID: PMC8831739.
    Citations:    
  18. Passos LSA, Becker-Greene D, Braulio R, Le TD, Gelape CL, de Almeida LFR, Rocha DPA, Gomes CAP, Esteves WAM, Passaglia LG, Dal-Bianco JP, Levine RA, Aikawa M, Hung J, Dutra WO, Nunes MCP, Aikawa E. Proinflammatory Matrix Metalloproteinase-1 Associates With Mitral Valve Leaflet Disruption Following Percutaneous Mitral Valvuloplasty. Front Cardiovasc Med. 2021; 8:804111. PMID: 35127864; PMCID: PMC8811173.
    Citations: 1     
  19. Tanaka T, Asano T, Okui T, Kuraoka S, Singh SA, Aikawa M, Aikawa E. Computational Screening Strategy for Drug Repurposing Identified Niclosamide as Inhibitor of Vascular Calcification. Front Cardiovasc Med. 2021; 8:826529. PMID: 35127876; PMCID: PMC8811128.
    Citations:    
  20. Iwata H, Osborn EA, Ughi GJ, Murakami K, Goettsch C, Hutcheson JD, Mauskapf A, Mattson PC, Libby P, Singh SA, Matamalas J, Aikawa E, Tearney GJ, Aikawa M, Jaffer FA. Highly Selective PPARa (Peroxisome Proliferator-Activated Receptor a) Agonist Pemafibrate Inhibits Stent Inflammation and Restenosis Assessed by Multimodality Molecular-Microstructural Imaging. J Am Heart Assoc. 2021 10 19; 10(20):e020834. PMID: 34632804; PMCID: PMC8751880.
    Citations:    Fields:    Translation:Animals
  21. Rogers MA, Hutcheson JD, Okui T, Goettsch C, Singh SA, Halu A, Schlotter F, Higashi H, Wang L, Whelan MC, Mlynarchik AK, Daugherty A, Nomura M, Aikawa M, Aikawa E. Dynamin-related protein 1 inhibition reduces hepatic PCSK9 secretion. Cardiovasc Res. 2021 09 28; 117(11):2340-2353. PMID: 33523181; PMCID: PMC8479802.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  22. Kuraoka S, Higashi H, Yanagihara Y, Sonawane AR, Mukai S, Mlynarchik AK, Whelan MC, Hottiger MO, Nasir W, Delanghe B, Aikawa M, Singh SA. A Novel Spectral Annotation Strategy Streamlines Reporting of Mono-ADP-ribosylated Peptides Derived from Mouse Liver and Spleen in Response to IFN-?. Mol Cell Proteomics. 2022 04; 21(4):100153. PMID: 34592425; PMCID: PMC9014395.
    Citations: 3     Fields:    Translation:Animals
  23. Hutcheson JD, Schlotter F, Creager MD, Li X, Pham T, Vyas P, Higashi H, Body SC, Aikawa M, Singh SA, Kos L, Aikawa E. Elastogenesis Correlates With Pigment Production in Murine Aortic Valve Leaflets. Front Cardiovasc Med. 2021; 8:678401. PMID: 34239903.
    Citations: 1     
  24. Ruiz JL, Hutcheson JD, Cardoso L, Bakhshian Nik A, Condado de Abreu A, Pham T, Buffolo F, Busatto S, Federici S, Ridolfi A, Aikawa M, Bertazzo S, Bergese P, Weinbaum S, Aikawa E. Nanoanalytical analysis of bisphosphonate-driven alterations of microcalcifications using a 3D hydrogel system and in vivo mouse model. Proc Natl Acad Sci U S A. 2021 04 06; 118(14). PMID: 33795519.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  25. Decano JL, Singh SA, Gasparotto Bueno C, Ho Lee L, Halu A, Chelvanambi S, Matamalas JT, Zhang H, Mlynarchik AK, Qiao J, Sharma A, Mukai S, Wang J, Anderson DG, Ozaki CK, Libby P, Aikawa E, Aikawa M. Systems Approach to Discovery of Therapeutic Targets for Vein Graft Disease: PPARa Pivotally Regulates Metabolism, Activation, and Heterogeneity of Macrophages and Lesion Development. Circulation. 2021 06 22; 143(25):2454-2470. PMID: 33821665; PMCID: PMC8212880.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  26. Singh SA, Andraski AB, Higashi H, Lee LH, Ramsaroop A, Sacks FM, Aikawa M. Metabolism of PLTP, CETP, and LCAT on multiple HDL sizes using the Orbitrap Fusion Lumos. JCI Insight. 2021 02 08; 6(3). PMID: 33351780.
    Citations: 1     Fields:    Translation:Humans
  27. Jha PK, Vijay A, Halu A, Uchida S, Aikawa M. Gene Expression Profiling Reveals the Shared and Distinct Transcriptional Signatures in Human Lung Epithelial Cells Infected With SARS-CoV-2, MERS-CoV, or SARS-CoV: Potential Implications in Cardiovascular Complications of COVID-19. Front Cardiovasc Med. 2020; 7:623012. PMID: 33521069.
    Citations: 12     
  28. Schlotter F, de Freitas RCC, Rogers MA, Blaser MC, Wu PJ, Higashi H, Halu A, Iqbal F, Andraski AB, Rodia CN, Kuraoka S, Wen JR, Creager M, Pham T, Hutcheson JD, Body SC, Kohan AB, Sacks FM, Aikawa M, Singh SA, Aikawa E. ApoC-III is a novel inducer of calcification in human aortic valves. J Biol Chem. 2021 Jan-Jun; 296:100193. PMID: 33334888.
    Citations: 7     Fields:    Translation:HumansCells
  29. Okui T, Iwashita M, Rogers MA, Halu A, Atkins SK, Kuraoka S, Abdelhamid I, Higashi H, Ramsaroop A, Aikawa M, Singh SA, Aikawa E. CROT (Carnitine O-Octanoyltransferase) Is a Novel Contributing Factor in Vascular Calcification via Promoting Fatty Acid Metabolism and Mitochondrial Dysfunction. Arterioscler Thromb Vasc Biol. 2021 02; 41(2):755-768. PMID: 33356393; PMCID: PMC8105275.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  30. Iqbal F, Lupieri A, Aikawa M, Aikawa E. Harnessing Single-Cell RNA Sequencing to Better Understand How Diseased Cells Behave the Way They Do in Cardiovascular Disease. Arterioscler Thromb Vasc Biol. 2021 02; 41(2):585-600. PMID: 33327741; PMCID: PMC8105278.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  31. Brandão SCS, Ramos JOX, Dompieri LT, Godoi ETAM, Figueiredo JL, Sarinho ESC, Chelvanambi S, Aikawa M. Is Toll-like receptor 4 involved in the severity of COVID-19 pathology in patients with cardiometabolic comorbidities? Cytokine Growth Factor Rev. 2021 04; 58:102-110. PMID: 32988728.
    Citations: 36     Fields:    Translation:HumansCells
  32. Rogers MA, Buffolo F, Schlotter F, Atkins SK, Lee LH, Halu A, Blaser MC, Tsolaki E, Higashi H, Luther K, Daaboul G, Bouten CVC, Body SC, Singh SA, Bertazzo S, Libby P, Aikawa M, Aikawa E. Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis. Sci Adv. 2020 09; 6(38). PMID: 32938681; PMCID: PMC7494353.
    Citations: 24     Fields:    
  33. Toyohara T, Roudnicky F, Florido MHC, Nakano T, Yu H, Katsuki S, Lee M, Meissner T, Friesen M, Davidow LS, Ptaszek L, Abe T, Rubin LL, Pereira AC, Aikawa M, Cowan CA. Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis. Cell Stem Cell. 2020 Jul 02; 27(1):178-180. PMID: 32619513.
    Citations: 2     Fields:    
  34. Kawakami R, Katsuki S, Travers R, Romero DC, Becker-Greene D, Passos LSA, Higashi H, Blaser MC, Sukhova GK, Buttigieg J, Kopriva D, Schmidt AM, Anderson DG, Singh SA, Cardoso L, Weinbaum S, Libby P, Aikawa M, Croce K, Aikawa E. S100A9-RAGE Axis Accelerates Formation of Macrophage-Mediated Extracellular Vesicle Microcalcification in Diabetes Mellitus. Arterioscler Thromb Vasc Biol. 2020 08; 40(8):1838-1853. PMID: 32460581.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  35. Toyohara T, Roudnicky F, Florido MHC, Nakano T, Yu H, Katsuki S, Lee M, Meissner T, Friesen M, Davidow LS, Ptaszek L, Abe T, Rubin LL, Pereira AC, Aikawa M, Cowan CA. Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis. Cell Stem Cell. 2020 07 02; 27(1):147-157.e7. PMID: 32413331.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  36. Figueiredo JL, Santa-Cruz F, Lima-Filho JL, Hilgendorf I, Aikawa M, Pittet MJ, Nahrendorf M, Weissleder R, Swirski FK, Robbins CS. A durable murine model of spleen transplantation with arterial and venous anastomoses. Sci Rep. 2020 03 04; 10(1):3979. PMID: 32132617.
    Citations: 1     Fields:    Translation:Animals
  37. Engelbrecht E, Levesque MV, He L, Vanlandewijck M, Nitzsche A, Niazi H, Kuo A, Singh SA, Aikawa M, Holton K, Proia RL, Kono M, Pu WT, Camerer E, Betsholtz C, Hla T. Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta. Elife. 2020 02 24; 9. PMID: 32091396.
    Citations: 15     Fields:    Translation:AnimalsCells
  38. Fehr AR, Singh SA, Kerr CM, Mukai S, Higashi H, Aikawa M. The impact of PARPs and ADP-ribosylation on inflammation and host-pathogen interactions. Genes Dev. 2020 03 01; 34(5-6):341-359. PMID: 32029454; PMCID: PMC7050484.
    Citations: 65     Fields:    Translation:HumansCells
  39. Rogers MA, Chen J, Nallamshetty S, Pham T, Goto S, Muehlschlegel JD, Libby P, Aikawa M, Aikawa E, Plutzky J. Retinoids Repress Human Cardiovascular Cell Calcification With Evidence for Distinct Selective Retinoid Modulator Effects. Arterioscler Thromb Vasc Biol. 2020 03; 40(3):656-669. PMID: 31852220; PMCID: PMC7047603.
    Citations: 10     Fields:    Translation:HumansCells
  40. Nakato R, Wada Y, Nakaki R, Nagae G, Katou Y, Tsutsumi S, Nakajima N, Fukuhara H, Iguchi A, Kohro T, Kanki Y, Saito Y, Kobayashi M, Izumi-Taguchi A, Osato N, Tatsuno K, Kamio A, Hayashi-Takanaka Y, Wada H, Ohta S, Aikawa M, Nakajima H, Nakamura M, McGee RC, Heppner KW, Kawakatsu T, Genno M, Yanase H, Kume H, Senbonmatsu T, Homma Y, Nishimura S, Mitsuyama T, Aburatani H, Kimura H, Shirahige K. Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells. Epigenetics Chromatin. 2019 12 19; 12(1):77. PMID: 31856914.
    Citations: 11     Fields:    Translation:HumansCells
  41. Arima N, Sasaki Y, Lee LH, Zhang H, Figueiredo JL, Mlynarchik AK, Qiao J, Yamada I, Higashi H, Ha AH, Halu A, Mizuno K, Singh SA, Yamazaki Y, Aikawa M. Multiorgan Systems Study Reveals Igfbp7 as a Suppressor of Gluconeogenesis after Gastric Bypass Surgery. J Proteome Res. 2020 01 03; 19(1):129-143. PMID: 31661273.
    Citations:    Fields:    Translation:HumansAnimalsCells
  42. Andraski AB, Singh SA, Lee LH, Higashi H, Smith N, Zhang B, Aikawa M, Sacks FM. Effects of Replacing Dietary Monounsaturated Fat With Carbohydrate on HDL (High-Density Lipoprotein) Protein Metabolism and Proteome Composition in Humans. Arterioscler Thromb Vasc Biol. 2019 11; 39(11):2411-2430. PMID: 31554421.
    Citations: 7     Fields:    Translation:HumansCTClinical Trials
  43. Aikawa M, Manabe I, Marx N. Editorial: New Trends in Vascular Inflammation Research: From Biology to Therapy. Front Cardiovasc Med. 2019; 6:102. PMID: 31555666; PMCID: PMC6722177.
    Citations: 1     
  44. Fruchart JC, Santos RD, Aguilar-Salinas C, Aikawa M, Al Rasadi K, Amarenco P, Barter PJ, Ceska R, Corsini A, Després JP, Duriez P, Eckel RH, Ezhov MV, Farnier M, Ginsberg HN, Hermans MP, Ishibashi S, Karpe F, Kodama T, Koenig W, Krempf M, Lim S, Lorenzatti AJ, McPherson R, Nuñez-Cortes JM, Nordestgaard BG, Ogawa H, Packard CJ, Plutzky J, Ponte-Negretti CI, Pradhan A, Ray KK, Reiner Ž, Ridker PM, Ruscica M, Sadikot S, Shimano H, Sritara P, Stock JK, Su TC, Susekov AV, Tartar A, Taskinen MR, Tenenbaum A, Tokgözoglu LS, Tomlinson B, Tybjærg-Hansen A, Valensi P, Vrablík M, Wahli W, Watts GF, Yamashita S, Yokote K, Zambon A, Libby P. The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMa) paradigm: conceptual framework and therapeutic potential : A consensus statement from the International Atherosclerosis Society (IAS) and the Residual Risk Reduction Initiative (R3i) Foundation. Cardiovasc Diabetol. 2019 06 04; 18(1):71. PMID: 31164165; PMCID: PMC6549355.
    Citations: 39     Fields:    Translation:HumansAnimalsCells