Harvard Catalyst Profiles

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Masanori Aikawa, Ph.D., M.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01HL149302 (AIKAWA, MASANORI) Jul 15, 2019 - Jun 30, 2023
    NIH/NHLBI
    Pro-inflammatory activation of human macrophages regulated by lncRNAs
    Role: Principal Investigator
  2. R13HL142296 (AIKAWA, MASANORI) Oct 1, 2018 - Sep 30, 2019
    NIH/NHLBI
    NAVBO Workshops at Vascular Biology 2018
    Role: Principal Investigator
  3. R01HL126901 (AIKAWA, MASANORI) Jan 1, 2016 - Dec 31, 2019
    NIH/NHLBI
    PARP9 and PARP14 in atherosclerosis
    Role: Principal Investigator
  4. R01HL107550 (AIKAWA, MASANORI) Jan 1, 2012 - Nov 30, 2015
    NIH/NHLBI
    Dll4 in macrophage activation
    Role: Principal Investigator
  5. R01HL066086 (AIKAWA, MASANORI) Apr 3, 2003 - Mar 31, 2007
    NIH/NHLBI
    Role of the CD40/CD40L dyad in atherosclerosis
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Toyohara T, Roudnicky F, Florido MHC, Nakano T, Yu H, Katsuki S, Lee M, Meissner T, Friesen M, Davidow LS, Ptaszek L, Abe T, Rubin LL, Pereira AC, Aikawa M, Cowan CA. Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis. Cell Stem Cell. 2020 Jul 02; 27(1):178-180. PMID: 32619513.
    Citations:    
  2. Kawakami R, Katsuki S, Travers R, Romero DC, Becker-Greene D, Passos LSA, Higashi H, Blaser MC, Sukhova GK, Buttigieg J, Kopriva D, Schmidt AM, Anderson DG, Singh SA, Cardoso L, Weinbaum S, Libby P, Aikawa M, Croce K, Aikawa E. S100A9-RAGE Axis Accelerates Formation of Macrophage-Mediated Extracellular Vesicle Microcalcification in Diabetes Mellitus. Arterioscler Thromb Vasc Biol. 2020 Aug; 40(8):1838-1853. PMID: 32460581.
    Citations:    
  3. Toyohara T, Roudnicky F, Florido MHC, Nakano T, Yu H, Katsuki S, Lee M, Meissner T, Friesen M, Davidow LS, Ptaszek L, Abe T, Rubin LL, Pereira AC, Aikawa M, Cowan CA. Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis. Cell Stem Cell. 2020 Jul 02; 27(1):147-157.e7. PMID: 32413331.
    Citations:    
  4. Figueiredo JL, Santa-Cruz F, Lima-Filho JL, Hilgendorf I, Aikawa M, Pittet MJ, Nahrendorf M, Weissleder R, Swirski FK, Robbins CS. A durable murine model of spleen transplantation with arterial and venous anastomoses. Sci Rep. 2020 Mar 04; 10(1):3979. PMID: 32132617.
    Citations:    
  5. Engelbrecht E, Levesque MV, He L, Vanlandewijck M, Nitzsche A, Niazi H, Kuo A, Singh SA, Aikawa M, Holton K, Proia RL, Kono M, Pu WT, Camerer E, Betsholtz C, Hla T. Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta. Elife. 2020 Feb 24; 9. PMID: 32091396.
    Citations:    
  6. Fehr AR, Singh SA, Kerr CM, Mukai S, Higashi H, Aikawa M. The impact of PARPs and ADP-ribosylation on inflammation and host-pathogen interactions. Genes Dev. 2020 03 01; 34(5-6):341-359. PMID: 32029454.
    Citations:    
  7. Rogers MA, Chen J, Nallamshetty S, Pham T, Goto S, Muehlschlegel JD, Libby P, Aikawa M, Aikawa E, Plutzky J. Retinoids Repress Human Cardiovascular Cell Calcification With Evidence for Distinct Selective Retinoid Modulator Effects. Arterioscler Thromb Vasc Biol. 2020 03; 40(3):656-669. PMID: 31852220.
    Citations:    
  8. Nakato R, Wada Y, Nakaki R, Nagae G, Katou Y, Tsutsumi S, Nakajima N, Fukuhara H, Iguchi A, Kohro T, Kanki Y, Saito Y, Kobayashi M, Izumi-Taguchi A, Osato N, Tatsuno K, Kamio A, Hayashi-Takanaka Y, Wada H, Ohta S, Aikawa M, Nakajima H, Nakamura M, McGee RC, Heppner KW, Kawakatsu T, Genno M, Yanase H, Kume H, Senbonmatsu T, Homma Y, Nishimura S, Mitsuyama T, Aburatani H, Kimura H, Shirahige K. Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells. Epigenetics Chromatin. 2019 12 19; 12(1):77. PMID: 31856914.
    Citations:    
  9. Arima N, Sasaki Y, Lee LH, Zhang H, Figueiredo JL, Mlynarchik AK, Qiao J, Yamada I, Higashi H, Ha AH, Halu A, Mizuno K, Singh SA, Yamazaki Y, Aikawa M. Multiorgan Systems Study Reveals Igfbp7 as a Suppressor of Gluconeogenesis after Gastric Bypass Surgery. J Proteome Res. 2020 01 03; 19(1):129-143. PMID: 31661273.
    Citations:    
  10. Andraski AB, Singh SA, Lee LH, Higashi H, Smith N, Zhang B, Aikawa M, Sacks FM. Effects of Replacing Dietary Monounsaturated Fat With Carbohydrate on HDL (High-Density Lipoprotein) Protein Metabolism and Proteome Composition in Humans. Arterioscler Thromb Vasc Biol. 2019 11; 39(11):2411-2430. PMID: 31554421.
    Citations:    
  11. Aikawa M, Manabe I, Marx N. Editorial: New Trends in Vascular Inflammation Research: From Biology to Therapy. Front Cardiovasc Med. 2019; 6:102. PMID: 31555666.
    Citations:    
  12. Fruchart JC, Santos RD, Aguilar-Salinas C, Aikawa M, Al Rasadi K, Amarenco P, Barter PJ, Ceska R, Corsini A, Després JP, Duriez P, Eckel RH, Ezhov MV, Farnier M, Ginsberg HN, Hermans MP, Ishibashi S, Karpe F, Kodama T, Koenig W, Krempf M, Lim S, Lorenzatti AJ, McPherson R, Nuñez-Cortes JM, Nordestgaard BG, Ogawa H, Packard CJ, Plutzky J, Ponte-Negretti CI, Pradhan A, Ray KK, Reiner Ž, Ridker PM, Ruscica M, Sadikot S, Shimano H, Sritara P, Stock JK, Su TC, Susekov AV, Tartar A, Taskinen MR, Tenenbaum A, Tokgözoglu LS, Tomlinson B, Tybjærg-Hansen A, Valensi P, Vrablík M, Wahli W, Watts GF, Yamashita S, Yokote K, Zambon A, Libby P. The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMa) paradigm: conceptual framework and therapeutic potential : A consensus statement from the International Atherosclerosis Society (IAS) and the Residual Risk Reduction Initiative (R3i) Foundation. Cardiovasc Diabetol. 2019 06 04; 18(1):71. PMID: 31164165.
    Citations:    
  13. Grunewald ME, Chen Y, Kuny C, Maejima T, Lease R, Ferraris D, Aikawa M, Sullivan CS, Perlman S, Fehr AR. The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression. PLoS Pathog. 2019 05; 15(5):e1007756. PMID: 31095648.
    Citations:    
  14. Goto S, Rogers MA, Blaser MC, Higashi H, Lee LH, Schlotter F, Body SC, Aikawa M, Singh SA, Aikawa E. Standardization of Human Calcific Aortic Valve Disease in vitro Modeling Reveals Passage-Dependent Calcification. Front Cardiovasc Med. 2019; 6:49. PMID: 31041314.
    Citations:    
  15. Higashi H, Maejima T, Lee LH, Yamazaki Y, Hottiger MO, Singh SA, Aikawa M. A Study into the ADP-Ribosylome of IFN-?-Stimulated THP-1 Human Macrophage-like Cells Identifies ARTD8/PARP14 and ARTD9/PARP9 ADP-Ribosylation. J Proteome Res. 2019 04 05; 18(4):1607-1622. PMID: 30848916.
    Citations:    
  16. Hutcheson JD, Goergen CJ, Schoen FJ, Aikawa M, Zilla P, Aikawa E, Gaudette GR. After 50 Years of Heart Transplants: What Does the Next 50 Years Hold for Cardiovascular Medicine? A Perspective From the International Society for Applied Cardiovascular Biology. Front Cardiovasc Med. 2019; 6:8. PMID: 30838213.
    Citations:    
  17. Nakano T, Katsuki S, Chen M, Decano JL, Halu A, Lee LH, Pestana DVS, Kum AST, Kuromoto RK, Golden WS, Boff MS, Guimaraes GC, Higashi H, Kauffman KJ, Maejima T, Suzuki T, Iwata H, Barabási AL, Aster JC, Anderson DG, Sharma A, Singh SA, Aikawa E, Aikawa M. Uremic Toxin Indoxyl Sulfate Promotes Proinflammatory Macrophage Activation Via the Interplay of OATP2B1 and Dll4-Notch Signaling. Circulation. 2019 01 02; 139(1):78-96. PMID: 30586693.
    Citations:    Fields:    
  18. Creager MD, Hohl T, Hutcheson JD, Moss AJ, Schlotter F, Blaser MC, Park MA, Lee LH, Singh SA, Alcaide-Corral CJ, Tavares AAS, Newby DE, Kijewski MF, Aikawa M, Di Carli M, Dweck MR, Aikawa E. 18F-Fluoride Signal Amplification Identifies Microcalcifications Associated With Atherosclerotic Plaque Instability in Positron Emission Tomography/Computed Tomography Images. Circ Cardiovasc Imaging. 2019 01; 12(1):e007835. PMID: 30642216.
    Citations:    Fields:    
  19. Lee LH, Halu A, Morgan S, Iwata H, Aikawa M, Singh SA. XINA: A Workflow for the Integration of Multiplexed Proteomics Kinetics Data with Network Analysis. J Proteome Res. 2019 02 01; 18(2):775-781. PMID: 30370770.
    Citations:    Fields:    
  20. Halu A, Wang JG, Iwata H, Mojcher A, Abib AL, Singh SA, Aikawa M, Sharma A. Context-enriched interactome powered by proteomics helps the identification of novel regulators of macrophage activation. Elife. 2018 10 10; 7. PMID: 30303482.
    Citations:    Fields:    Translation:HumansCells
  21. Decano JL, Aikawa M. Dynamic Macrophages: Understanding Mechanisms of Activation as Guide to Therapy for Atherosclerotic Vascular Disease. Front Cardiovasc Med. 2018; 5:97. PMID: 30123798.
    Citations:    
  22. Schlotter F, Halu A, Goto S, Blaser MC, Body SC, Lee LH, Higashi H, DeLaughter DM, Hutcheson JD, Vyas P, Pham T, Rogers MA, Sharma A, Seidman CE, Loscalzo J, Seidman JG, Aikawa M, Singh SA, Aikawa E. Spatiotemporal Multi-Omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease. Circulation. 2018 07 24; 138(4):377-393. PMID: 29588317.
    Citations:    Fields:    
  23. Sharma A, Halu A, Decano JL, Padi M, Liu YY, Prasad RB, Fadista J, Santolini M, Menche J, Weiss ST, Vidal M, Silverman EK, Aikawa M, Barabási AL, Groop L, Loscalzo J. Controllability in an islet specific regulatory network identifies the transcriptional factor NFATC4, which regulates Type 2 Diabetes associated genes. NPJ Syst Biol Appl. 2018; 4:25. PMID: 29977601.
    Citations:    
  24. Hagita S, Rogers MA, Pham T, Wen JR, Mlynarchik AK, Aikawa M, Aikawa E. Transcriptional control of intestinal cholesterol absorption, adipose energy expenditure and lipid handling by Sortilin. Sci Rep. 2018 06 13; 8(1):9006. PMID: 29899496.
    Citations:    Fields:    
  25. van der Valk DC, van der Ven CFT, Blaser MC, Grolman JM, Wu PJ, Fenton OS, Lee LH, Tibbitt MW, Andresen JL, Wen JR, Ha AH, Buffolo F, van Mil A, Bouten CVC, Body SC, Mooney DJ, Sluijter JPG, Aikawa M, Hjortnaes J, Langer R, Aikawa E. Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics. Nanomaterials (Basel). 2018 May 03; 8(5). PMID: 29751516.
    Citations:    
  26. Itoh S, Mizuno K, Aikawa M, Aikawa E. Dimerization of sortilin regulates its trafficking to extracellular vesicles. J Biol Chem. 2018 03 23; 293(12):4532-4544. PMID: 29382723.
    Citations: 1     Fields:    Translation:HumansCells
  27. Rogers MA, Aikawa M, Aikawa E. Macrophage Heterogeneity Complicates Reversal of Calcification in Cardiovascular Tissues. Circ Res. 2017 06 23; 121(1):5-7. PMID: 28642321.
    Citations:    Fields:    
  28. Rogers MA, Maldonado N, Hutcheson JD, Goettsch C, Goto S, Yamada I, Faits T, Sesaki H, Aikawa M, Aikawa E. Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative Stress. Circ Res. 2017 Jul 21; 121(3):220-233. PMID: 28607103.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  29. Saito M, Aikawa M, Komori Y, Haba H, Takács S. Production cross sections of 169Yb and Tm isotopes in deuteron-induced reactions on 169Tm. Appl Radiat Isot. 2017 Jul; 125:23-26. PMID: 28395221.
    Citations:    
  30. Goettsch C, Iwata H, Hutcheson JD, O'Donnell CJ, Chapurlat R, Cook NR, Aikawa M, Szulc P, Aikawa E. Serum Sortilin Associates With Aortic Calcification and Cardiovascular Risk in Men. Arterioscler Thromb Vasc Biol. 2017 05; 37(5):1005-1011. PMID: 28279970.
    Citations:    Fields:    Translation:HumansCells
  31. Singh SA, Aikawa M. Unbiased and targeted mass spectrometry for the HDL proteome. Curr Opin Lipidol. 2017 02; 28(1):68-77. PMID: 28002079.
    Citations:    Fields:    Translation:HumansAnimals
  32. Lee LH, Andraski AB, Pieper B, Higashi H, Sacks FM, Aikawa M, Singh SA. Automation of PRM-dependent D3-Leu tracer enrichment in HDL to study the metabolism of apoA-I, LCAT and other apolipoproteins. Proteomics. 2017 01; 17(1-2). PMID: 27862954.
    Citations:    Fields:    Translation:Humans
  33. Yabusaki K, Hutcheson JD, Vyas P, Bertazzo S, Body SC, Aikawa M, Aikawa E. Quantification of Calcified Particles in Human Valve Tissue Reveals Asymmetry of Calcific Aortic Valve Disease Development. Front Cardiovasc Med. 2016; 3:44. PMID: 27867942.
    Citations:    
  34. Iwata H, Goettsch C, Sharma A, Ricchiuto P, Goh WW, Halu A, Yamada I, Yoshida H, Hara T, Wei M, Inoue N, Fukuda D, Mojcher A, Mattson PC, Barabási AL, Boothby M, Aikawa E, Singh SA, Aikawa M. PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation. Nat Commun. 2016 10 31; 7:12849. PMID: 27796300.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  35. Nakano T, Fukuda D, Koga J, Aikawa M. Delta-Like Ligand 4-Notch Signaling in Macrophage Activation. Arterioscler Thromb Vasc Biol. 2016 10; 36(10):2038-47. PMID: 27562914.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  36. Singh SA, Aikawa E, Aikawa M. Current Trends and Future Perspectives of State-of-the-Art Proteomics Technologies Applied to Cardiovascular Disease Research. Circ J. 2016 Jul 25; 80(8):1674-83. PMID: 27430298.
    Citations: 1     Fields:    Translation:HumansAnimals
  37. Goettsch C, Hutcheson JD, Hagita S, Rogers MA, Creager MD, Pham T, Choi J, Mlynarchik AK, Pieper B, Kjolby M, Aikawa M, Aikawa E. A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification. Atherosclerosis. 2016 08; 251:109-118. PMID: 27318830.
    Citations: 6     Fields:    Translation:AnimalsCells
  38. Ghiassian SD, Menche J, Chasman DI, Giulianini F, Wang R, Ricchiuto P, Aikawa M, Iwata H, Müller C, Zeller T, Sharma A, Wild P, Lackner K, Singh S, Ridker PM, Blankenberg S, Barabási AL, Loscalzo J. Endophenotype Network Models: Common Core of Complex Diseases. Sci Rep. 2016 06 09; 6:27414. PMID: 27278246.
    Citations: 12     Fields:    Translation:Humans
  39. Decano JL, Mattson PC, Aikawa M. Macrophages in Vascular Inflammation: Origins and Functions. Curr Atheroscler Rep. 2016 Jun; 18(6):34. PMID: 27125207.
    Citations: 4     Fields:    Translation:HumansCells
  40. Goettsch C, Hutcheson JD, Aikawa M, Iwata H, Pham T, Nykjaer A, Kjolby M, Rogers M, Michel T, Shibasaki M, Hagita S, Kramann R, Rader DJ, Libby P, Singh SA, Aikawa E. Sortilin mediates vascular calcification via its recruitment into extracellular vesicles. J Clin Invest. 2016 Apr 01; 126(4):1323-36. PMID: 26950419.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  41. Singh SA, Andraski AB, Pieper B, Goh W, Mendivil CO, Sacks FM, Aikawa M. Multiple apolipoprotein kinetics measured in human HDL by high-resolution/accurate mass parallel reaction monitoring. J Lipid Res. 2016 Apr; 57(4):714-28. PMID: 26862155.
    Citations: 6     Fields:    Translation:HumansCells
  42. Hutcheson JD, Goettsch C, Bertazzo S, Maldonado N, Ruiz JL, Goh W, Yabusaki K, Faits T, Bouten C, Franck G, Quillard T, Libby P, Aikawa M, Weinbaum S, Aikawa E. Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques. Nat Mater. 2016 Mar; 15(3):335-43. PMID: 26752654.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  43. Sun X, Haas ME, Miao J, Mehta A, Graham MJ, Crooke RM, Pais de Barros JP, Wang JG, Aikawa M, Masson D, Biddinger SB. Insulin Dissociates the Effects of Liver X Receptor on Lipogenesis, Endoplasmic Reticulum Stress, and Inflammation. J Biol Chem. 2016 Jan 15; 291(3):1115-22. PMID: 26511317.
    Citations: 4     Fields:    Translation:AnimalsCells
  44. Wang JG, Aikawa M. Toll-like receptors and Src-family kinases in atherosclerosis -- focus on macrophages. Circ J. 2015; 79(11):2332-4. PMID: 26467082.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  45. Koga JI, Nakano T, Dahlman JE, Figueiredo JL, Zhang H, Decano J, Khan OF, Niida T, Iwata H, Aster JC, Yagita H, Anderson DG, Ozaki CK, Aikawa M. Macrophage Notch Ligand Delta-Like 4 Promotes Vein Graft Lesion Development: Implications for the Treatment of Vein Graft Failure. Arterioscler Thromb Vasc Biol. 2015 Nov; 35(11):2343-2353. PMID: 26404485.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  46. Shibasaki M, Wang JG, Figueiredo JL, New SE, Quillard T, Goettsch C, Koga J, Sonoki H, Matsumoto J, Aikawa M, Aikawa E. Pitavastatin Reduces Inflammation in Atherosclerotic Plaques in Apolipoprotein E-Deficient Mice with Late Stage Renal Disease. PLoS One. 2015; 10(9):e0138047. PMID: 26367531.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  47. Singh SA, Miyosawa K, Aikawa M. Mass spectrometry meets the challenge of understanding the complexity of the lipoproteome: recent findings regarding proteins involved in dyslipidemia and cardiovascular disease. Expert Rev Proteomics. 2015; 12(5):519-32. PMID: 26325144.
    Citations: 3     Fields:    Translation:HumansAnimals
  48. Ricchiuto P, Iwata H, Yabusaki K, Yamada I, Pieper B, Sharma A, Aikawa M, Singh SA. mIMT-visHTS: A novel method for multiplexing isobaric mass tagged datasets with an accompanying visualization high throughput screening tool for protein profiling. J Proteomics. 2015 Oct 14; 128:132-40. PMID: 26232111.
    Citations: 2     Fields:    Translation:AnimalsCells
  49. Sasaki Y, Ohta M, Desai D, Figueiredo JL, Whelan MC, Sugano T, Yamabi M, Yano W, Faits T, Yabusaki K, Zhang H, Mlynarchik AK, Inoue K, Mizuno K, Aikawa M. Angiopoietin Like Protein 2 (ANGPTL2) Promotes Adipose Tissue Macrophage and T lymphocyte Accumulation and Leads to Insulin Resistance. PLoS One. 2015; 10(7):e0131176. PMID: 26132105.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  50. Miyosawa K, Watanabe Y, Murakami K, Murakami T, Shibata H, Iwashita M, Yamazaki H, Yamazaki K, Ohgiya T, Shibuya K, Mizuno K, Tanabe S, Singh SA, Aikawa M. New CETP inhibitor K-312 reduces PCSK9 expression: a potential effect on LDL cholesterol metabolism. Am J Physiol Endocrinol Metab. 2015 Jul 15; 309(2):E177-90. PMID: 26015437.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  51. Lei Y, Iwashita M, Choi J, Aikawa M, Aikawa E. N-acetylglucosamine-1-Phosphate Transferase Suppresses Lysosomal Hydrolases in Dysfunctional Osteoclasts: A Potential Mechanism for Vascular Calcification. J Cardiovasc Dev Dis. 2015 Apr 15; 2(2):31-47. PMID: 29371511.
    Citations:    
  52. Lu H, Aikawa M. Many faces of matrix metalloproteinases in aortic aneurysms. Arterioscler Thromb Vasc Biol. 2015 Apr; 35(4):752-4. PMID: 25810296.
    Citations: 5     Fields:    Translation:AnimalsCells
  53. Figueiredo JL, Aikawa M, Zheng C, Aaron J, Lax L, Libby P, de Lima Filho JL, Gruener S, Fingerle J, Haap W, Hartmann G, Aikawa E. Selective cathepsin S inhibition attenuates atherosclerosis in apolipoprotein E-deficient mice with chronic renal disease. Am J Pathol. 2015 Apr; 185(4):1156-66. PMID: 25680278.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  54. Hutcheson JD, Goettsch C, Pham T, Iwashita M, Aikawa M, Singh SA, Aikawa E. Enrichment of calcifying extracellular vesicles using density-based ultracentrifugation protocol. J Extracell Vesicles. 2014; 3:25129. PMID: 25491249.
    Citations: 10     
  55. Takase K, Aikawa M, Okada K, Watanabe Y, Okamoto K, Sato H, Nonaka K, Yamaguchi S, Sakuramoto S, Koyama I, Miyazawa M. Development of novel treatment with a bioabsorbable esophageal patch for benign esophageal stricture. Dis Esophagus. 2015 Nov-Dec; 28(8):728-34. PMID: 25286827.
    Citations:    Fields:    Translation:Animals
  56. Miyazaki T, Chiuve S, Sacks FM, Ridker PM, Libby P, Aikawa M. Plasma pentraxin 3 levels do not predict coronary events but reflect metabolic disorders in patients with coronary artery disease in the CARE trial. PLoS One. 2014; 9(4):e94073. PMID: 24705587.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  57. Yabusaki K, Faits T, McMullen E, Figueiredo JL, Aikawa M, Aikawa E. A novel quantitative approach for eliminating sample-to-sample variation using a hue saturation value analysis program. PLoS One. 2014; 9(3):e89627. PMID: 24595280.
    Citations: 3     Fields:    
  58. Koga J, Aikawa M. Application of anti-ligand antibodies to inhibit Notch signaling. Methods Mol Biol. 2014; 1187:335-42. PMID: 25053501.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  59. Itou T, Maldonado N, Yamada I, Goettsch C, Matsumoto J, Aikawa M, Singh S, Aikawa E. Cystathionine ?-lyase accelerates osteoclast differentiation: identification of a novel regulator of osteoclastogenesis by proteomic analysis. Arterioscler Thromb Vasc Biol. 2014 Mar; 34(3):626-34. PMID: 24357058.
    Citations: 8     Fields:    Translation:AnimalsCells
  60. Fukuda D, Aikawa M. Expanding role of delta-like 4 mediated notch signaling in cardiovascular and metabolic diseases. Circ J. 2013; 77(10):2462-8. PMID: 24025398.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  61. Wang JG, Aikawa E, Aikawa M. Leukocyte-derived microparticles as proinflammatory mediators in atherosclerosis. J Am Coll Cardiol. 2013 Oct 15; 62(16):1442-5. PMID: 23707315.
    Citations: 3     Fields:    Translation:HumansCells
  62. Zheng C, Morishige K, Aikawa M. Functional molecular imaging linking macrophages to reverse cholesterol transport. Circ J. 2013; 77(6):1403-6. PMID: 23685734.
    Citations:    Fields:    Translation:HumansAnimals
  63. New SE, Goettsch C, Aikawa M, Marchini JF, Shibasaki M, Yabusaki K, Libby P, Shanahan CM, Croce K, Aikawa E. Macrophage-derived matrix vesicles: an alternative novel mechanism for microcalcification in atherosclerotic plaques. Circ Res. 2013 Jun 21; 113(1):72-7. PMID: 23616621.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  64. Iwata H, Aikawa M. Liver-artery interactions via the plasminogen-CD36 axis in macrophage foam cell formation: new evidence for the role of remote organ crosstalk in atherosclerosis. Circulation. 2013 Mar 19; 127(11):1173-6. PMID: 23509031.
    Citations: 5     Fields:    Translation:AnimalsCells
  65. Abe J, Manabe I, Aikawa M, Aikawa E. Cardiovascular Inflammation 2012: Reactive Oxygen Species, SUMOylation, and Biomarkers in Cardiovascular Inflammation. Int J Inflam. 2013; 2013:953463. PMID: 23555068.
    Citations: 2     
  66. Zheng C, Aikawa M. High-density lipoproteins: from function to therapy. J Am Coll Cardiol. 2012 Dec 11; 60(23):2380-3. PMID: 23141492.
    Citations: 12     Fields:    Translation:Humans
  67. Zheng C, Azcutia V, Aikawa E, Figueiredo JL, Croce K, Sonoki H, Sacks FM, Luscinskas FW, Aikawa M. Statins suppress apolipoprotein CIII-induced vascular endothelial cell activation and monocyte adhesion. Eur Heart J. 2013 Feb; 34(8):615-24. PMID: 22927557.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  68. Azcutia V, Stefanidakis M, Tsuboi N, Mayadas T, Croce KJ, Fukuda D, Aikawa M, Newton G, Luscinskas FW. Endothelial CD47 promotes vascular endothelial-cadherin tyrosine phosphorylation and participates in T cell recruitment at sites of inflammation in vivo. J Immunol. 2012 Sep 01; 189(5):2553-62. PMID: 22815286.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  69. Fukuda D, Aikawa E, Swirski FK, Novobrantseva TI, Kotelianski V, Gorgun CZ, Chudnovskiy A, Yamazaki H, Croce K, Weissleder R, Aster JC, Hotamisligil GS, Yagita H, Aikawa M. Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders. Proc Natl Acad Sci U S A. 2012 Jul 03; 109(27):E1868-77. PMID: 22699504.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  70. Aikawa M, Manabe I, Chester A, Aikawa E. Cardiovascular inflammation. Int J Inflam. 2012; 2012:904608. PMID: 22518345.
    Citations: 1     
  71. Koga J, Aikawa M. Crosstalk between macrophages and smooth muscle cells in atherosclerotic vascular diseases. Vascul Pharmacol. 2012 Aug 19; 57(1):24-8. PMID: 22402259.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  72. Quillard T, Tesmenitsky Y, Croce K, Travers R, Shvartz E, Koskinas KC, Sukhova GK, Aikawa E, Aikawa M, Libby P. Selective inhibition of matrix metalloproteinase-13 increases collagen content of established mouse atherosclerosis. Arterioscler Thromb Vasc Biol. 2011 Nov; 31(11):2464-72. PMID: 21903941.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  73. Umeda H, Aikawa M, Libby P. Liberation of desmosine and isodesmosine as amino acids from insoluble elastin by elastolytic proteases. Biochem Biophys Res Commun. 2011 Jul 29; 411(2):281-6. PMID: 21726534.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  74. Fukuda D, Aikawa M. Intimal smooth muscle cells: the context-dependent origin. Circulation. 2010 Nov 16; 122(20):2005-8. PMID: 21041686.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  75. Morishige K, Kacher DF, Libby P, Josephson L, Ganz P, Weissleder R, Aikawa M. High-resolution magnetic resonance imaging enhanced with superparamagnetic nanoparticles measures macrophage burden in atherosclerosis. Circulation. 2010 Oct 26; 122(17):1707-15. PMID: 20937980.
    Citations: 40     Fields:    Translation:AnimalsCells
  76. Bu DX, Tarrio M, Grabie N, Zhang Y, Yamazaki H, Stavrakis G, Maganto-Garcia E, Pepper-Cunningham Z, Jarolim P, Aikawa M, García-Cardeña G, Lichtman AH. Statin-induced Krüppel-like factor 2 expression in human and mouse T cells reduces inflammatory and pathogenic responses. J Clin Invest. 2010 Jun; 120(6):1961-70. PMID: 20440076.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  77. Zheng C, Sacks FM, Aikawa M. Modern Insights Into Diseases From Molecules to Man: Adhesion Molecules (Preedy V, ed). Apolipoproteins and adhesion molecules. 2010; 429-445.
  78. Morishige K, Kacher DF, Libby P, Josephson L, Ganz P, Weissleder R, Aikawa M. Circulation. High- resolution MRI enhanced with superparamagnetic nanoparticles measures macrophage burden in atherosclerosis. 2010; 122:1707-1715.
  79. Fukuda D, Aikawa M. Circulation. Intimal smooth muscle cells: the context-dependent origin. 2010; 122:2005-2008.
  80. Deguchi JO, Yamazaki H, Aikawa E, Aikawa M. Chronic hypoxia activates the Akt and beta-catenin pathways in human macrophages. Arterioscler Thromb Vasc Biol. 2009 Oct; 29(10):1664-70. PMID: 19644051.
    Citations: 12     Fields:    Translation:HumansCells
  81. Aikawa E, Aikawa M, Libby P, Figueiredo JL, Rusanescu G, Iwamoto Y, Fukuda D, Kohler RH, Shi GP, Jaffer FA, Weissleder R. Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease. Circulation. 2009 Apr 07; 119(13):1785-94. PMID: 19307473.
    Citations: 92     Fields:    Translation:HumansAnimalsCells
  82. Deguchi JO, Huang H, Libby P, Aikawa E, Whittaker P, Sylvan J, Lee RT, Aikawa M. Genetically engineered resistance for MMP collagenases promotes abdominal aortic aneurysm formation in mice infused with angiotensin II. Lab Invest. 2009 Mar; 89(3):315-26. PMID: 19153555.
    Citations: 19     Fields:    Translation:Animals
  83. Sun Y, Ishibashi M, Seimon T, Lee M, Sharma SM, Fitzgerald KA, Samokhin AO, Wang Y, Sayers S, Aikawa M, Jerome WG, Ostrowski MC, Bromme D, Libby P, Tabas IA, Welch CL, Tall AR. Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K. Circ Res. 2009 Feb 27; 104(4):455-65. PMID: 19122179.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  84. Kawakami A, Osaka M, Aikawa M, Uematsu S, Akira S, Libby P, Shimokado K, Sacks FM, Yoshida M. Toll-like receptor 2 mediates apolipoprotein CIII-induced monocyte activation. Circ Res. 2008 Dec 05; 103(12):1402-9. PMID: 18974386.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  85. Minami M, Shimizu K, Okamoto Y, Folco E, Ilasaca ML, Feinberg MW, Aikawa M, Libby P. Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation. J Biol Chem. 2008 Apr 11; 283(15):9692-703. PMID: 18270204.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  86. Schneider F, Sukhova GK, Aikawa M, Canner J, Gerdes N, Tang SM, Shi GP, Apte SS, Libby P. Matrix-metalloproteinase-14 deficiency in bone-marrow-derived cells promotes collagen accumulation in mouse atherosclerotic plaques. Circulation. 2008 Feb 19; 117(7):931-9. PMID: 18250269.
    Citations: 41     Fields:    Translation:AnimalsCells
  87. Miyazaki T, Aikawa E, Aikawa M. Immunol Endocr Metab Agents in Med Chem. Biology of cholesterol lowering in atherosclerotic plaques. 2008; 8:105-115.
  88. Aikawa E, Nahrendorf M, Figueiredo JL, Swirski FK, Shtatland T, Kohler RH, Jaffer FA, Aikawa M, Weissleder R. Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo. Circulation. 2007 Dec 11; 116(24):2841-50. PMID: 18040026.
    Citations: 152     Fields:    Translation:HumansAnimals
  89. Aikawa M. The balance of power: the law of Yin and Yang in smooth muscle cell fate. Is YY1 a vascular protector? Circ Res. 2007 Jul 20; 101(2):111-3. PMID: 17641231.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  90. Ahluwalia N, Lin AY, Tager AM, Pruitt IE, Anderson TJ, Kristo F, Shen D, Cruz AR, Aikawa M, Luster AD, Gerszten RE. Inhibited aortic aneurysm formation in BLT1-deficient mice. J Immunol. 2007 Jul 01; 179(1):691-7. PMID: 17579092.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  91. Fung E, Tang SM, Canner JP, Morishige K, Arboleda-Velasquez JF, Cardoso AA, Carlesso N, Aster JC, Aikawa M. Delta-like 4 induces notch signaling in macrophages: implications for inflammation. Circulation. 2007 Jun 12; 115(23):2948-56. PMID: 17533181.
    Citations: 59     Fields:    Translation:HumansCells
  92. Zirlik A, Maier C, Gerdes N, MacFarlane L, Soosairajah J, Bavendiek U, Ahrens I, Ernst S, Bassler N, Missiou A, Patko Z, Aikawa M, Schönbeck U, Bode C, Libby P, Peter K. CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1. Circulation. 2007 Mar 27; 115(12):1571-80. PMID: 17372166.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  93. Zirlik A, Bavendiek U, Libby P, MacFarlane L, Gerdes N, Jagielska J, Ernst S, Aikawa M, Nakano H, Tsitsikov E, Schönbeck U. TRAF-1, -2, -3, -5, and -6 are induced in atherosclerotic plaques and differentially mediate proinflammatory functions of CD40L in endothelial cells. Arterioscler Thromb Vasc Biol. 2007 May; 27(5):1101-7. PMID: 17332487.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  94. Aikawa E, Nahrendorf M, Sosnovik D, Lok VM, Jaffer FA, Aikawa M, Weissleder R. Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease. Circulation. 2007 Jan 23; 115(3):377-86. PMID: 17224478.
    Citations: 122     Fields:    Translation:AnimalsCells
  95. Tsimikas S, Aikawa M, Miller FJ, Miller ER, Torzewski M, Lentz SR, Bergmark C, Heistad DD, Libby P, Witztum JL. Increased plasma oxidized phospholipid:apolipoprotein B-100 ratio with concomitant depletion of oxidized phospholipids from atherosclerotic lesions after dietary lipid-lowering: a potential biomarker of early atherosclerosis regression. Arterioscler Thromb Vasc Biol. 2007 Jan; 27(1):175-81. PMID: 17082490.
    Citations: 21     Fields:    Translation:AnimalsCells
  96. Kawakami A, Aikawa M, Nitta N, Yoshida M, Libby P, Sacks FM. Apolipoprotein CIII-induced THP-1 cell adhesion to endothelial cells involves pertussis toxin-sensitive G protein- and protein kinase C alpha-mediated nuclear factor-kappaB activation. Arterioscler Thromb Vasc Biol. 2007 Jan; 27(1):219-25. PMID: 17038637.
    Citations: 27     Fields:    Translation:HumansCells
  97. Kawakami A, Aikawa M, Alcaide P, Luscinskas FW, Libby P, Sacks FM. Apolipoprotein CIII induces expression of vascular cell adhesion molecule-1 in vascular endothelial cells and increases adhesion of monocytic cells. Circulation. 2006 Aug 15; 114(7):681-7. PMID: 16894036.
    Citations: 67     Fields:    Translation:HumansCells
  98. Deguchi JO, Aikawa M, Tung CH, Aikawa E, Kim DE, Ntziachristos V, Weissleder R, Libby P. Inflammation in atherosclerosis: visualizing matrix metalloproteinase action in macrophages in vivo. Circulation. 2006 Jul 04; 114(1):55-62. PMID: 16801460.
    Citations: 113     Fields:    Translation:AnimalsCells
  99. Aikawa E, Whittaker P, Farber M, Mendelson K, Padera RF, Aikawa M, Schoen FJ. Human semilunar cardiac valve remodeling by activated cells from fetus to adult: implications for postnatal adaptation, pathology, and tissue engineering. Circulation. 2006 Mar 14; 113(10):1344-52. PMID: 16534030.
    Citations: 114     Fields:    Translation:HumansCells
  100. Kawakami A, Aikawa M, Libby P, Alcaide P, Luscinskas FW, Sacks FM. Apolipoprotein CIII in apolipoprotein B lipoproteins enhances the adhesion of human monocytic cells to endothelial cells. Circulation. 2006 Feb 07; 113(5):691-700. PMID: 16461842.
    Citations: 50     Fields:    Translation:HumansCells
  101. Libby P, Aikawa M, Jain MK. Vascular endothelium and atherosclerosis. Handb Exp Pharmacol. 2006; (176 Pt 2):285-306. PMID: 16999230.
    Citations: 32     Fields:    Translation:HumansAnimals
  102. Sugiyama S, Kugiyama K, Nakamura S, Kataoka K, Aikawa M, Shimizu K, Koide S, Mitchell RN, Ogawa H, Libby P. Characterization of smooth muscle-like cells in circulating human peripheral blood. Atherosclerosis. 2006 Aug; 187(2):351-62. PMID: 16253262.
    Citations: 17     Fields:    Translation:HumansCells
  103. Deguchi JO, Aikawa E, Libby P, Vachon JR, Inada M, Krane SM, Whittaker P, Aikawa M. Matrix metalloproteinase-13/collagenase-3 deletion promotes collagen accumulation and organization in mouse atherosclerotic plaques. Circulation. 2005 Oct 25; 112(17):2708-15. PMID: 16230484.
    Citations: 67     Fields:    Translation:Animals
  104. Larose E, Yeghiazarians Y, Libby P, Yucel EK, Aikawa M, Kacher DF, Aikawa E, Kinlay S, Schoen FJ, Selwyn AP, Ganz P. Characterization of human atherosclerotic plaques by intravascular magnetic resonance imaging. Circulation. 2005 Oct 11; 112(15):2324-31. PMID: 16203910.
    Citations: 32     Fields:    Translation:Humans
  105. Arboleda-Velasquez JF, Rampal R, Fung E, Darland DC, Liu M, Martinez MC, Donahue CP, Navarro-Gonzalez MF, Libby P, D'Amore PA, Aikawa M, Haltiwanger RS, Kosik KS. CADASIL mutations impair Notch3 glycosylation by Fringe. Hum Mol Genet. 2005 Jun 15; 14(12):1631-9. PMID: 15857853.
    Citations: 10     Fields:    Translation:AnimalsCells
  106. Aikawa M, Libby P. Lipid lowering therapy in atherosclerosis. Semin Vasc Med. 2004 Nov; 4(4):357-66. PMID: 15861316.
    Citations: 8     Fields:    Translation:HumansAnimals
  107. Rabkin-Aikawa E, Aikawa M, Farber M, Kratz JR, Garcia-Cardena G, Kouchoukos NT, Mitchell MB, Jonas RA, Schoen FJ. Clinical pulmonary autograft valves: pathologic evidence of adaptive remodeling in the aortic site. J Thorac Cardiovasc Surg. 2004 Oct; 128(4):552-61. PMID: 15457156.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  108. Fukumoto Y, Deguchi JO, Libby P, Rabkin-Aikawa E, Sakata Y, Chin MT, Hill CC, Lawler PR, Varo N, Schoen FJ, Krane SM, Aikawa M. Genetically determined resistance to collagenase action augments interstitial collagen accumulation in atherosclerotic plaques. Circulation. 2004 Oct 05; 110(14):1953-9. PMID: 15451791.
    Citations: 23     Fields:    Translation:AnimalsCells
  109. Rabkin-Aikawa E, Farber M, Aikawa M, Schoen FJ. Dynamic and reversible changes of interstitial cell phenotype during remodeling of cardiac valves. J Heart Valve Dis. 2004 Sep; 13(5):841-7. PMID: 15473488.
    Citations: 90     Fields:    Translation:HumansAnimalsCells
  110. Aikawa M. Effects of statin therapy on vascular dysfunction. Coron Artery Dis. 2004 Aug; 15(5):227-33. PMID: 15238817.
    Citations: 1     Fields:    Translation:HumansCells
  111. Hosgor M, Karaca I, Ozer E, Erdag G, Ulukus C, Fescekoglu O, Aikawa M. The role of smooth muscle cell differentiation in the mechanism of obliteration of processus vaginalis. J Pediatr Surg. 2004 Jul; 39(7):1018-23. PMID: 15213890.
    Citations: 3     Fields:    Translation:Humans
  112. Sugiyama S, Kugiyama K, Aikawa M, Nakamura S, Ogawa H, Libby P. Hypochlorous acid, a macrophage product, induces endothelial apoptosis and tissue factor expression: involvement of myeloperoxidase-mediated oxidant in plaque erosion and thrombogenesis. Arterioscler Thromb Vasc Biol. 2004 Jul; 24(7):1309-14. PMID: 15142860.
    Citations: 60     Fields:    Translation:HumansCells
  113. Aikawa M, Libby P. The vulnerable atherosclerotic plaque: pathogenesis and therapeutic approach. Cardiovasc Pathol. 2004 May-Jun; 13(3):125-38. PMID: 15081469.
    Citations: 39     Fields:    Translation:HumansAnimals
  114. Aikawa M, Libby P. Atherosclerotic plaque inflammation: the final frontier? Can J Cardiol. 2004 May 01; 20(6):631-4. PMID: 15152295.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  115. Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, Rumberger J, Badimon JJ, Stefanadis C, Moreno P, Pasterkamp G, Fayad Z, Stone PH, Waxman S, Raggi P, Madjid M, Zarrabi A, Burke A, Yuan C, Fitzgerald PJ, Siscovick DS, de Korte CL, Aikawa M, Airaksinen KE, Assmann G, Becker CR, Chesebro JH, Farb A, Galis ZS, Jackson C, Jang IK, Koenig W, Lodder RA, March K, Demirovic J, Navab M, Priori SG, Rekhter MD, Bahr R, Grundy SM, Mehran R, Colombo A, Boerwinkle E, Ballantyne C, Insull W, Schwartz RS, Vogel R, Serruys PW, Hansson GK, Faxon DP, Kaul S, Drexler H, Greenland P, Muller JE, Virmani R, Ridker PM, Zipes DP, Shah PK, Willerson JT. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part II. Circulation. 2003 Oct 14; 108(15):1772-8. PMID: 14557340.
    Citations: 216     Fields:    Translation:HumansAnimalsPHPublic Health
  116. Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, Rumberger J, Badimon JJ, Stefanadis C, Moreno P, Pasterkamp G, Fayad Z, Stone PH, Waxman S, Raggi P, Madjid M, Zarrabi A, Burke A, Yuan C, Fitzgerald PJ, Siscovick DS, de Korte CL, Aikawa M, Juhani Airaksinen KE, Assmann G, Becker CR, Chesebro JH, Farb A, Galis ZS, Jackson C, Jang IK, Koenig W, Lodder RA, March K, Demirovic J, Navab M, Priori SG, Rekhter MD, Bahr R, Grundy SM, Mehran R, Colombo A, Boerwinkle E, Ballantyne C, Insull W, Schwartz RS, Vogel R, Serruys PW, Hansson GK, Faxon DP, Kaul S, Drexler H, Greenland P, Muller JE, Virmani R, Ridker PM, Zipes DP, Shah PK, Willerson JT. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I. Circulation. 2003 Oct 07; 108(14):1664-72. PMID: 14530185.
    Citations: 466     Fields:    Translation:Humans
  117. Shimizu K, Aikawa M, Takayama K, Libby P, Mitchell RN. Direct anti-inflammatory mechanisms contribute to attenuation of experimental allograft arteriosclerosis by statins. Circulation. 2003 Oct 28; 108(17):2113-20. PMID: 14517172.
    Citations: 21     Fields:    Translation:AnimalsCells
  118. Lindsey ML, Yoshioka J, MacGillivray C, Muangman S, Gannon J, Verghese A, Aikawa M, Libby P, Krane SM, Lee RT. Effect of a cleavage-resistant collagen mutation on left ventricular remodeling. Circ Res. 2003 Aug 08; 93(3):238-45. PMID: 12855673.
    Citations: 19     Fields:    Translation:Animals
  119. Libby P, Aikawa M. Mechanisms of plaque stabilization with statins. Am J Cardiol. 2003 Feb 20; 91(4A):4B-8B. PMID: 12615292.
    Citations: 34     Fields:    Translation:HumansAnimals
  120. Libby P, Aikawa M. Effects of statins in reducing thrombotic risk and modulating plaque vulnerability. Clin Cardiol. 2003 Jan; 26(1 Suppl 1):I11-4. PMID: 12539817.
    Citations: 8     Fields:    Translation:HumansAnimalsPHPublic Health
  121. Libby P, Aikawa M. Stabilization of atherosclerotic plaques: new mechanisms and clinical targets. Nat Med. 2002 Nov; 8(11):1257-62. PMID: 12411953.
    Citations: 99     Fields:    Translation:HumansAnimals
  122. Aikawa M, Sugiyama S, Hill CC, Voglic SJ, Rabkin E, Fukumoto Y, Schoen FJ, Witztum JL, Libby P. Lipid lowering reduces oxidative stress and endothelial cell activation in rabbit atheroma. Circulation. 2002 Sep 10; 106(11):1390-6. PMID: 12221058.
    Citations: 34     Fields:    Translation:Animals
  123. Rabkin E, Hoerstrup SP, Aikawa M, Mayer JE, Schoen FJ. Evolution of cell phenotype and extracellular matrix in tissue-engineered heart valves during in-vitro maturation and in-vivo remodeling. J Heart Valve Dis. 2002 May; 11(3):308-14; discussion 314. PMID: 12056720.
    Citations: 26     Fields:    Translation:AnimalsCells
  124. Libby P, Aikawa M. Vitamin C, collagen, and cracks in the plaque. Circulation. 2002 Mar 26; 105(12):1396-8. PMID: 11914242.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  125. Lindsey ML, Gannon J, Aikawa M, Schoen FJ, Rabkin E, Lopresti-Morrow L, Crawford J, Black S, Libby P, Mitchell PG, Lee RT. Selective matrix metalloproteinase inhibition reduces left ventricular remodeling but does not inhibit angiogenesis after myocardial infarction. Circulation. 2002 Feb 12; 105(6):753-8. PMID: 11839633.
    Citations: 50     Fields:    Translation:Animals
  126. Akaki M, Nagayasu E, Nakano Y, Aikawa M. Surface charge of Plasmodium falciparum merozoites as revealed by atomic force microscopy with surface potential spectroscopy. Parasitol Res. 2002 Jan; 88(1):16-20. PMID: 11822732.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  127. Nagaie T, Morita M, Nakagawa M, Itoh S, Aikawa M, Yagi S, Wakiyama S, Kitte T, Shimotakahara A, Kawaguchi A, Wada H, Nakanishi K, Kihara K, Koyanagi N. [A remarkably improved multimetastatic gastric cancer with the use of TS-1 and CDDP]. Gan To Kagaku Ryoho. 2001 Dec; 28(13):2069-72. PMID: 11791387.
    Citations:    Fields:    Translation:Humans
  128. Rabkin E, Aikawa M, Stone JR, Fukumoto Y, Libby P, Schoen FJ. Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valves. Circulation. 2001 Nov 20; 104(21):2525-32. PMID: 11714645.
    Citations: 155     Fields:    Translation:HumansCells
  129. Kikuchi M, Looareesuwan S, Ubalee R, Tasanor O, Suzuki F, Wattanagoon Y, Na-Bangchang K, Kimura A, Aikawa M, Hirayama K. Association of adhesion molecule PECAM-1/CD31 polymorphism with susceptibility to cerebral malaria in Thais. Parasitol Int. 2001 Nov; 50(4):235-9. PMID: 11719109.
    Citations: 13     Fields:    Translation:HumansAnimals
  130. Osaki T, Oyama T, Inoue M, Gu CD, Kodate M, Aikawa M, So T, Mizukami M, Mitsudomi T, Yasumoto K. Molecular biological markers and micrometastasis in resected non-small-cell lung cancer. Prognostic implications. Jpn J Thorac Cardiovasc Surg. 2001 Sep; 49(9):545-51. PMID: 11577444.
    Citations: 4     Fields:    Translation:Humans
  131. Osaki T, Oyama T, Takenoyama M, So T, Yamashita T, Aikawa M, Ono K, Yasumoto K. [Results of surgical treatment for primary lung cancer; time trends of survival and clinicopathologic features]. J UOEH. 2001 Sep 01; 23(3):277-83. PMID: 11570051.
    Citations: 3     Fields:    Translation:Humans
  132. Sakamoto H, Aikawa M, Hill CC, Weiss D, Taylor WR, Libby P, Lee RT. Biomechanical strain induces class a scavenger receptor expression in human monocyte/macrophages and THP-1 cells: a potential mechanism of increased atherosclerosis in hypertension. Circulation. 2001 Jul 03; 104(1):109-14. PMID: 11435347.
    Citations: 12     Fields:    Translation:HumansAnimalsCells