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Masanori Aikawa, Ph.D., M.D.

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Mentoring
Available: 11/30/20, Expires: 12/31/21

[Background] Many lines of evidence, including our own, established that macrophages contribute importantly to cardiovascular disease such as atherosclerosis. Despite the availability of potent therapeutics against modifiable risk factors (e.g., statins for hypercholesterolemia), many patients still suffer with major complications of atherosclerosis including myocardial infarction. Our laboratory has thus explored new mechanisms for pro-inflammatory activation of macrophages as therapeutic targets. Interestingly, we have learned in recent years that macrophages are a heterogeneous group of cells. They may have several subpopulations, such as pro-inflammatory and anti-inflammatory clusters. It is important to understand how what factors regulate macrophage heterogeneity as a guide to the development of new drugs.

[Goals] How many subpopulations do macrophage have? We aim to identify subpopulations of human primary macrophages derived from the circulating blood using several single cell analysis platform, including single cell RNA-sequencing and mass cytometry (CyTOF). To analyze large complex data from such screening, we use our own bioinformatics programs, machine learning, and network analysis, followed by comprehensive validation using cell and molecular biology experiments. The ultimate goal of this comprehensive, multidisciplinary project is to discover mechanisms that regulate macrophage heterogeneity as novel therapeutic targets for precision medicine against cardiovascular diseases. Anticipated discoveries from this project should also help to develop new therapies for various other inflammatory diseases such as cancer, Alzheimer’s disease, metabolic disorders, fatty liver, and irritable bowel syndrome.

[Center for Interdisciplinary Cardiovascular Sciences (CICS)] This project is conducted at CICS of Divisions of Cardiovascular Medicine and Network Medicine of Brigham and Women's Hospital under the supervision of Masanori Aikawa, MD, PhD, Founding Director. CICS uses various innovative technologies, including proteomics, transcriptomics, single cell analysis, our own bioinformatics programs, and machine learning. We are a diverse group of investigators, including vascular biologist, immunologist, biochemist, and data scientists who specialize in machine learning, bioinformatics, or systems biology. https://cics.bwh.harvard.edu/

[Requirements] Any students with extraordinary passion and curiosity for innovative medical sciences are suited for the project. But, considering the nature of this multidisciplinary project, excellent communication skills are required. Prior experience in laboratory research is also advantageous.

Available: 01/04/21, Expires: 12/31/21

[Background] Despite the availability of potent therapeutics (e.g., cholesterol-lowering statins), many patients still suffer with cardiovascular diseases such as myocardial infarction. One of major challenges in medical practice and drug development is the heterogeneity of human diseases, which makes it hard to prevent clinical events in many patients with one drug. It is thus important to understand how heterogeneous each cardiovascular disease is and what factors regulate such heterogeneity.

[Goals] How many subpopulations does each cardiovascular disease have? We aim to identify subpopulations of patients with cardiovascular diseases using the big patient data from electronic health records, clinical samples, machine learning, systems biology, multi-omics, and cell and molecular biology. Our current focus include coronary artery disease, heart failure, and complications of COVID-19. The ultimate goal of this comprehensive, multidisciplinary project is to discover mechanisms that regulate disease heterogeneity as novel therapeutic targets for precision medicine (e.g., how can you prevent disease progression in patients in a subpopulation with the highest risk with a new drug?).

[Center for Interdisciplinary Cardiovascular Sciences (CICS)] This project is conducted at CICS of Divisions of Cardiovascular Medicine and Network Medicine of Brigham and Women's Hospital under the supervision of Masanori Aikawa, MD, PhD, Founding Director. CICS uses various innovative technologies, including proteomics, transcriptomics, single cell analysis, our own bioinformatics programs, and machine learning. We are a diverse group of investigators, including vascular biologist, immunologist, biochemist, and data scientists who specialize in machine learning, bioinformatics, or systems biology. https://cics.bwh.harvard.edu/

[Requirements] Any students with extraordinary passion and curiosity for innovative medical sciences are suited for the project. But, considering the nature of this multidisciplinary project, excellent communication skills are required. Prior experience in computational analysis is also advantageous, but not essential.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL149302 (AIKAWA, MASANORI) Jul 15, 2019 - Jun 30, 2023
    NIH
    Pro-inflammatory activation of human macrophages regulated by lncRNAs
    Role: Principal Investigator
  2. R13HL142296 (AIKAWA, MASANORI) Oct 1, 2018 - Sep 30, 2019
    NIH
    NAVBO Workshops at Vascular Biology 2018
    Role: Principal Investigator
  3. R01HL126901 (AIKAWA, MASANORI) Jan 1, 2016 - Dec 31, 2019
    NIH
    PARP9 and PARP14 in atherosclerosis
    Role: Principal Investigator
  4. R01HL107550 (AIKAWA, MASANORI) Jan 1, 2012 - Nov 30, 2015
    NIH
    Dll4 in macrophage activation
    Role: Principal Investigator
  5. R01HL066086 (AIKAWA, MASANORI) Apr 3, 2003 - Mar 31, 2007
    NIH
    Role of the CD40/CD40L dyad in atherosclerosis
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Singh SA, Andraski AB, Higashi H, Lee LH, Ramsaroop A, Sacks FM, Aikawa M. Metabolism of PLTP, CETP, and LCAT on multiple HDL sizes using the Orbitrap Fusion Lumos. JCI Insight. 2021 Feb 08; 6(3). PMID: 33351780.
    Citations:    Fields:    
  2. Rogers MA, Hutcheson JD, Okui T, Goettsch C, Singh SA, Halu A, Schlotter F, Higashi H, Wang L, Whelan MC, Mlynarchik AK, Daugherty A, Nomura M, Aikawa M, Aikawa E. Dynamin-related protein 1 inhibition reduces hepatic PCSK9 secretion. Cardiovasc Res. 2021 Feb 01. PMID: 33523181.
    Citations:    Fields:    
  3. Jha PK, Vijay A, Halu A, Uchida S, Aikawa M. Gene Expression Profiling Reveals the Shared and Distinct Transcriptional Signatures in Human Lung Epithelial Cells Infected With SARS-CoV-2, MERS-CoV, or SARS-CoV: Potential Implications in Cardiovascular Complications of COVID-19. Front Cardiovasc Med. 2020; 7:623012. PMID: 33521069.
    Citations:    
  4. Okui T, Iwashita M, Rogers MA, Halu A, Atkins SK, Kuraoka S, Abdelhamid I, Higashi H, Ramsaroop A, Aikawa M, Singh SA, Aikawa E. CROT (Carnitine O-Octanoyltransferase) Is a Novel Contributing Factor in Vascular Calcification via Promoting Fatty Acid Metabolism and Mitochondrial Dysfunction. Arterioscler Thromb Vasc Biol. 2020 Dec 24; ATVBAHA120315007. PMID: 33356393.
    Citations:    Fields:    
  5. Schlotter F, de Freitas RCC, Rogers MA, Blaser MC, Wu PJ, Higashi H, Halu A, Iqbal F, Andraski AB, Rodia CN, Kuraoka S, Wen JR, Creager M, Pham T, Hutcheson JD, Body SC, Kohan AB, Sacks FM, Aikawa M, Singh SA, Aikawa E. ApoC-III is a novel inducer of calcification in human aortic valves. J Biol Chem. 2020 Dec 17. PMID: 33334888.
    Citations:    Fields:    
  6. Iqbal F, Lupieri A, Aikawa M, Aikawa E. Harnessing Single-Cell RNA Sequencing to Better Understand How Diseased Cells Behave the Way They Do in Cardiovascular Disease. Arterioscler Thromb Vasc Biol. 2020 Dec 17; ATVBAHA120314776. PMID: 33327741.
    Citations:    Fields:    
  7. Brandão SCS, Ramos JOX, Dompieri LT, Godoi ETAM, Figueiredo JL, Sarinho ESC, Chelvanambi S, Aikawa M. Is Toll-like receptor 4 involved in the severity of COVID-19 pathology in patients with cardiometabolic comorbidities? Cytokine Growth Factor Rev. 2021 04; 58:102-110. PMID: 32988728.
    Citations: 3     Fields:    
  8. Rogers MA, Buffolo F, Schlotter F, Atkins SK, Lee LH, Halu A, Blaser MC, Tsolaki E, Higashi H, Luther K, Daaboul G, Bouten CVC, Body SC, Singh SA, Bertazzo S, Libby P, Aikawa M, Aikawa E. Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis. Sci Adv. 2020 Sep; 6(38). PMID: 32938681.
    Citations: 4     Fields:    
  9. Toyohara T, Roudnicky F, Florido MHC, Nakano T, Yu H, Katsuki S, Lee M, Meissner T, Friesen M, Davidow LS, Ptaszek L, Abe T, Rubin LL, Pereira AC, Aikawa M, Cowan CA. Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis. Cell Stem Cell. 2020 Jul 02; 27(1):178-180. PMID: 32619513.
    Citations: 1     Fields:    
  10. Kawakami R, Katsuki S, Travers R, Romero DC, Becker-Greene D, Passos LSA, Higashi H, Blaser MC, Sukhova GK, Buttigieg J, Kopriva D, Schmidt AM, Anderson DG, Singh SA, Cardoso L, Weinbaum S, Libby P, Aikawa M, Croce K, Aikawa E. S100A9-RAGE Axis Accelerates Formation of Macrophage-Mediated Extracellular Vesicle Microcalcification in Diabetes Mellitus. Arterioscler Thromb Vasc Biol. 2020 08; 40(8):1838-1853. PMID: 32460581.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  11. Toyohara T, Roudnicky F, Florido MHC, Nakano T, Yu H, Katsuki S, Lee M, Meissner T, Friesen M, Davidow LS, Ptaszek L, Abe T, Rubin LL, Pereira AC, Aikawa M, Cowan CA. Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis. Cell Stem Cell. 2020 07 02; 27(1):147-157.e7. PMID: 32413331.
    Citations: 2     Fields:    
  12. Figueiredo JL, Santa-Cruz F, Lima-Filho JL, Hilgendorf I, Aikawa M, Pittet MJ, Nahrendorf M, Weissleder R, Swirski FK, Robbins CS. A durable murine model of spleen transplantation with arterial and venous anastomoses. Sci Rep. 2020 03 04; 10(1):3979. PMID: 32132617.
    Citations:    Fields:    Translation:Animals
  13. Engelbrecht E, Levesque MV, He L, Vanlandewijck M, Nitzsche A, Niazi H, Kuo A, Singh SA, Aikawa M, Holton K, Proia RL, Kono M, Pu WT, Camerer E, Betsholtz C, Hla T. Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta. Elife. 2020 02 24; 9. PMID: 32091396.
    Citations: 5     Fields:    
  14. Fehr AR, Singh SA, Kerr CM, Mukai S, Higashi H, Aikawa M. The impact of PARPs and ADP-ribosylation on inflammation and host-pathogen interactions. Genes Dev. 2020 03 01; 34(5-6):341-359. PMID: 32029454.
    Citations: 23     Fields:    Translation:HumansCells
  15. Rogers MA, Chen J, Nallamshetty S, Pham T, Goto S, Muehlschlegel JD, Libby P, Aikawa M, Aikawa E, Plutzky J. Retinoids Repress Human Cardiovascular Cell Calcification With Evidence for Distinct Selective Retinoid Modulator Effects. Arterioscler Thromb Vasc Biol. 2020 03; 40(3):656-669. PMID: 31852220.
    Citations: 3     Fields:    Translation:HumansCells
  16. Nakato R, Wada Y, Nakaki R, Nagae G, Katou Y, Tsutsumi S, Nakajima N, Fukuhara H, Iguchi A, Kohro T, Kanki Y, Saito Y, Kobayashi M, Izumi-Taguchi A, Osato N, Tatsuno K, Kamio A, Hayashi-Takanaka Y, Wada H, Ohta S, Aikawa M, Nakajima H, Nakamura M, McGee RC, Heppner KW, Kawakatsu T, Genno M, Yanase H, Kume H, Senbonmatsu T, Homma Y, Nishimura S, Mitsuyama T, Aburatani H, Kimura H, Shirahige K. Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells. Epigenetics Chromatin. 2019 12 19; 12(1):77. PMID: 31856914.
    Citations: 3     Fields:    Translation:HumansCells
  17. Arima N, Sasaki Y, Lee LH, Zhang H, Figueiredo JL, Mlynarchik AK, Qiao J, Yamada I, Higashi H, Ha AH, Halu A, Mizuno K, Singh SA, Yamazaki Y, Aikawa M. Multiorgan Systems Study Reveals Igfbp7 as a Suppressor of Gluconeogenesis after Gastric Bypass Surgery. J Proteome Res. 2020 01 03; 19(1):129-143. PMID: 31661273.
    Citations:    Fields:    
  18. Andraski AB, Singh SA, Lee LH, Higashi H, Smith N, Zhang B, Aikawa M, Sacks FM. Effects of Replacing Dietary Monounsaturated Fat With Carbohydrate on HDL (High-Density Lipoprotein) Protein Metabolism and Proteome Composition in Humans. Arterioscler Thromb Vasc Biol. 2019 11; 39(11):2411-2430. PMID: 31554421.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  19. Aikawa M, Manabe I, Marx N. Editorial: New Trends in Vascular Inflammation Research: From Biology to Therapy. Front Cardiovasc Med. 2019; 6:102. PMID: 31555666.
    Citations: 1     
  20. Fruchart JC, Santos RD, Aguilar-Salinas C, Aikawa M, Al Rasadi K, Amarenco P, Barter PJ, Ceska R, Corsini A, Després JP, Duriez P, Eckel RH, Ezhov MV, Farnier M, Ginsberg HN, Hermans MP, Ishibashi S, Karpe F, Kodama T, Koenig W, Krempf M, Lim S, Lorenzatti AJ, McPherson R, Nuñez-Cortes JM, Nordestgaard BG, Ogawa H, Packard CJ, Plutzky J, Ponte-Negretti CI, Pradhan A, Ray KK, Reiner Ž, Ridker PM, Ruscica M, Sadikot S, Shimano H, Sritara P, Stock JK, Su TC, Susekov AV, Tartar A, Taskinen MR, Tenenbaum A, Tokgözoglu LS, Tomlinson B, Tybjærg-Hansen A, Valensi P, Vrablík M, Wahli W, Watts GF, Yamashita S, Yokote K, Zambon A, Libby P. The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMa) paradigm: conceptual framework and therapeutic potential : A consensus statement from the International Atherosclerosis Society (IAS) and the Residual Risk Reduction Initiative (R3i) Foundation. Cardiovasc Diabetol. 2019 06 04; 18(1):71. PMID: 31164165.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  21. Grunewald ME, Chen Y, Kuny C, Maejima T, Lease R, Ferraris D, Aikawa M, Sullivan CS, Perlman S, Fehr AR. The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression. PLoS Pathog. 2019 05; 15(5):e1007756. PMID: 31095648.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  22. Goto S, Rogers MA, Blaser MC, Higashi H, Lee LH, Schlotter F, Body SC, Aikawa M, Singh SA, Aikawa E. Standardization of Human Calcific Aortic Valve Disease in vitro Modeling Reveals Passage-Dependent Calcification. Front Cardiovasc Med. 2019; 6:49. PMID: 31041314.
    Citations: 7     
  23. Higashi H, Maejima T, Lee LH, Yamazaki Y, Hottiger MO, Singh SA, Aikawa M. A Study into the ADP-Ribosylome of IFN-?-Stimulated THP-1 Human Macrophage-like Cells Identifies ARTD8/PARP14 and ARTD9/PARP9 ADP-Ribosylation. J Proteome Res. 2019 04 05; 18(4):1607-1622. PMID: 30848916.
    Citations: 3     Fields:    Translation:HumansCells
  24. Hutcheson JD, Goergen CJ, Schoen FJ, Aikawa M, Zilla P, Aikawa E, Gaudette GR. After 50 Years of Heart Transplants: What Does the Next 50 Years Hold for Cardiovascular Medicine? A Perspective From the International Society for Applied Cardiovascular Biology. Front Cardiovasc Med. 2019; 6:8. PMID: 30838213.
    Citations:    
  25. Nakano T, Katsuki S, Chen M, Decano JL, Halu A, Lee LH, Pestana DVS, Kum AST, Kuromoto RK, Golden WS, Boff MS, Guimaraes GC, Higashi H, Kauffman KJ, Maejima T, Suzuki T, Iwata H, Barabási AL, Aster JC, Anderson DG, Sharma A, Singh SA, Aikawa E, Aikawa M. Uremic Toxin Indoxyl Sulfate Promotes Proinflammatory Macrophage Activation Via the Interplay of OATP2B1 and Dll4-Notch Signaling. Circulation. 2019 01 02; 139(1):78-96. PMID: 30586693.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  26. Creager MD, Hohl T, Hutcheson JD, Moss AJ, Schlotter F, Blaser MC, Park MA, Lee LH, Singh SA, Alcaide-Corral CJ, Tavares AAS, Newby DE, Kijewski MF, Aikawa M, Di Carli M, Dweck MR, Aikawa E. 18F-Fluoride Signal Amplification Identifies Microcalcifications Associated With Atherosclerotic Plaque Instability in Positron Emission Tomography/Computed Tomography Images. Circ Cardiovasc Imaging. 2019 01; 12(1):e007835. PMID: 30642216.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  27. Lee LH, Halu A, Morgan S, Iwata H, Aikawa M, Singh SA. XINA: A Workflow for the Integration of Multiplexed Proteomics Kinetics Data with Network Analysis. J Proteome Res. 2019 02 01; 18(2):775-781. PMID: 30370770.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  28. Halu A, Wang JG, Iwata H, Mojcher A, Abib AL, Singh SA, Aikawa M, Sharma A. Context-enriched interactome powered by proteomics helps the identification of novel regulators of macrophage activation. Elife. 2018 10 10; 7. PMID: 30303482.
    Citations: 4     Fields:    Translation:HumansCells
  29. Decano JL, Aikawa M. Dynamic Macrophages: Understanding Mechanisms of Activation as Guide to Therapy for Atherosclerotic Vascular Disease. Front Cardiovasc Med. 2018; 5:97. PMID: 30123798.
    Citations: 6     
  30. Schlotter F, Halu A, Goto S, Blaser MC, Body SC, Lee LH, Higashi H, DeLaughter DM, Hutcheson JD, Vyas P, Pham T, Rogers MA, Sharma A, Seidman CE, Loscalzo J, Seidman JG, Aikawa M, Singh SA, Aikawa E. Spatiotemporal Multi-Omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease. Circulation. 2018 07 24; 138(4):377-393. PMID: 29588317.
    Citations: 30     Fields:    Translation:HumansCells
  31. Sharma A, Halu A, Decano JL, Padi M, Liu YY, Prasad RB, Fadista J, Santolini M, Menche J, Weiss ST, Vidal M, Silverman EK, Aikawa M, Barabási AL, Groop L, Loscalzo J. Controllability in an islet specific regulatory network identifies the transcriptional factor NFATC4, which regulates Type 2 Diabetes associated genes. NPJ Syst Biol Appl. 2018; 4:25. PMID: 29977601.
    Citations: 5     Fields:    
  32. Hagita S, Rogers MA, Pham T, Wen JR, Mlynarchik AK, Aikawa M, Aikawa E. Transcriptional control of intestinal cholesterol absorption, adipose energy expenditure and lipid handling by Sortilin. Sci Rep. 2018 06 13; 8(1):9006. PMID: 29899496.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  33. van der Valk DC, van der Ven CFT, Blaser MC, Grolman JM, Wu PJ, Fenton OS, Lee LH, Tibbitt MW, Andresen JL, Wen JR, Ha AH, Buffolo F, van Mil A, Bouten CVC, Body SC, Mooney DJ, Sluijter JPG, Aikawa M, Hjortnaes J, Langer R, Aikawa E. Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics. Nanomaterials (Basel). 2018 May 03; 8(5). PMID: 29751516.
    Citations: 16     
  34. Itoh S, Mizuno K, Aikawa M, Aikawa E. Dimerization of sortilin regulates its trafficking to extracellular vesicles. J Biol Chem. 2018 03 23; 293(12):4532-4544. PMID: 29382723.
    Citations: 8     Fields:    Translation:HumansCells
  35. Rogers MA, Aikawa M, Aikawa E. Macrophage Heterogeneity Complicates Reversal of Calcification in Cardiovascular Tissues. Circ Res. 2017 06 23; 121(1):5-7. PMID: 28642321.
    Citations: 5     Fields:    Translation:HumansCells
  36. Rogers MA, Maldonado N, Hutcheson JD, Goettsch C, Goto S, Yamada I, Faits T, Sesaki H, Aikawa M, Aikawa E. Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative Stress. Circ Res. 2017 Jul 21; 121(3):220-233. PMID: 28607103.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  37. Saito M, Aikawa M, Komori Y, Haba H, Takács S. Production cross sections of 169Yb and Tm isotopes in deuteron-induced reactions on 169Tm. Appl Radiat Isot. 2017 Jul; 125:23-26. PMID: 28395221.
    Citations:    Fields:    
  38. Goettsch C, Iwata H, Hutcheson JD, O'Donnell CJ, Chapurlat R, Cook NR, Aikawa M, Szulc P, Aikawa E. Serum Sortilin Associates With Aortic Calcification and Cardiovascular Risk in Men. Arterioscler Thromb Vasc Biol. 2017 05; 37(5):1005-1011. PMID: 28279970.
    Citations: 10     Fields:    Translation:HumansCells
  39. Singh SA, Aikawa M. Unbiased and targeted mass spectrometry for the HDL proteome. Curr Opin Lipidol. 2017 02; 28(1):68-77. PMID: 28002079.
    Citations: 6     Fields:    Translation:HumansAnimals
  40. Lee LH, Andraski AB, Pieper B, Higashi H, Sacks FM, Aikawa M, Singh SA. Automation of PRM-dependent D3-Leu tracer enrichment in HDL to study the metabolism of apoA-I, LCAT and other apolipoproteins. Proteomics. 2017 01; 17(1-2). PMID: 27862954.
    Citations: 2     Fields:    Translation:Humans
  41. Yabusaki K, Hutcheson JD, Vyas P, Bertazzo S, Body SC, Aikawa M, Aikawa E. Quantification of Calcified Particles in Human Valve Tissue Reveals Asymmetry of Calcific Aortic Valve Disease Development. Front Cardiovasc Med. 2016; 3:44. PMID: 27867942.
    Citations: 2     
  42. Iwata H, Goettsch C, Sharma A, Ricchiuto P, Goh WW, Halu A, Yamada I, Yoshida H, Hara T, Wei M, Inoue N, Fukuda D, Mojcher A, Mattson PC, Barabási AL, Boothby M, Aikawa E, Singh SA, Aikawa M. PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation. Nat Commun. 2016 10 31; 7:12849. PMID: 27796300.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  43. Nakano T, Fukuda D, Koga J, Aikawa M. Delta-Like Ligand 4-Notch Signaling in Macrophage Activation. Arterioscler Thromb Vasc Biol. 2016 10; 36(10):2038-47. PMID: 27562914.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  44. Singh SA, Aikawa E, Aikawa M. Current Trends and Future Perspectives of State-of-the-Art Proteomics Technologies Applied to Cardiovascular Disease Research. Circ J. 2016 Jul 25; 80(8):1674-83. PMID: 27430298.
    Citations: 2     Fields:    Translation:HumansAnimals
  45. Goettsch C, Hutcheson JD, Hagita S, Rogers MA, Creager MD, Pham T, Choi J, Mlynarchik AK, Pieper B, Kjolby M, Aikawa M, Aikawa E. A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification. Atherosclerosis. 2016 08; 251:109-118. PMID: 27318830.
    Citations: 22     Fields:    Translation:AnimalsCells
  46. Ghiassian SD, Menche J, Chasman DI, Giulianini F, Wang R, Ricchiuto P, Aikawa M, Iwata H, Müller C, Zeller T, Sharma A, Wild P, Lackner K, Singh S, Ridker PM, Blankenberg S, Barabási AL, Loscalzo J. Endophenotype Network Models: Common Core of Complex Diseases. Sci Rep. 2016 06 09; 6:27414. PMID: 27278246.
    Citations: 28     Fields:    Translation:Humans
  47. Decano JL, Mattson PC, Aikawa M. Macrophages in Vascular Inflammation: Origins and Functions. Curr Atheroscler Rep. 2016 Jun; 18(6):34. PMID: 27125207.
    Citations: 9     Fields:    Translation:HumansCells
  48. Goettsch C, Hutcheson JD, Aikawa M, Iwata H, Pham T, Nykjaer A, Kjolby M, Rogers M, Michel T, Shibasaki M, Hagita S, Kramann R, Rader DJ, Libby P, Singh SA, Aikawa E. Sortilin mediates vascular calcification via its recruitment into extracellular vesicles. J Clin Invest. 2016 Apr 01; 126(4):1323-36. PMID: 26950419.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  49. Singh SA, Andraski AB, Pieper B, Goh W, Mendivil CO, Sacks FM, Aikawa M. Multiple apolipoprotein kinetics measured in human HDL by high-resolution/accurate mass parallel reaction monitoring. J Lipid Res. 2016 Apr; 57(4):714-28. PMID: 26862155.
    Citations: 15     Fields:    Translation:HumansCells
  50. Hutcheson JD, Goettsch C, Bertazzo S, Maldonado N, Ruiz JL, Goh W, Yabusaki K, Faits T, Bouten C, Franck G, Quillard T, Libby P, Aikawa M, Weinbaum S, Aikawa E. Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques. Nat Mater. 2016 Mar; 15(3):335-43. PMID: 26752654.
    Citations: 77     Fields:    Translation:HumansAnimalsCells
  51. Sun X, Haas ME, Miao J, Mehta A, Graham MJ, Crooke RM, Pais de Barros JP, Wang JG, Aikawa M, Masson D, Biddinger SB. Insulin Dissociates the Effects of Liver X Receptor on Lipogenesis, Endoplasmic Reticulum Stress, and Inflammation. J Biol Chem. 2016 Jan 15; 291(3):1115-22. PMID: 26511317.
    Citations: 6     Fields:    Translation:AnimalsCells
  52. Wang JG, Aikawa M. Toll-like receptors and Src-family kinases in atherosclerosis -- focus on macrophages. Circ J. 2015; 79(11):2332-4. PMID: 26467082.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  53. Koga JI, Nakano T, Dahlman JE, Figueiredo JL, Zhang H, Decano J, Khan OF, Niida T, Iwata H, Aster JC, Yagita H, Anderson DG, Ozaki CK, Aikawa M. Macrophage Notch Ligand Delta-Like 4 Promotes Vein Graft Lesion Development: Implications for the Treatment of Vein Graft Failure. Arterioscler Thromb Vasc Biol. 2015 Nov; 35(11):2343-2353. PMID: 26404485.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  54. Shibasaki M, Wang JG, Figueiredo JL, New SE, Quillard T, Goettsch C, Koga J, Sonoki H, Matsumoto J, Aikawa M, Aikawa E. Pitavastatin Reduces Inflammation in Atherosclerotic Plaques in Apolipoprotein E-Deficient Mice with Late Stage Renal Disease. PLoS One. 2015; 10(9):e0138047. PMID: 26367531.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  55. Singh SA, Miyosawa K, Aikawa M. Mass spectrometry meets the challenge of understanding the complexity of the lipoproteome: recent findings regarding proteins involved in dyslipidemia and cardiovascular disease. Expert Rev Proteomics. 2015; 12(5):519-32. PMID: 26325144.
    Citations: 3     Fields:    Translation:HumansAnimals
  56. Ricchiuto P, Iwata H, Yabusaki K, Yamada I, Pieper B, Sharma A, Aikawa M, Singh SA. mIMT-visHTS: A novel method for multiplexing isobaric mass tagged datasets with an accompanying visualization high throughput screening tool for protein profiling. J Proteomics. 2015 Oct 14; 128:132-40. PMID: 26232111.
    Citations: 2     Fields:    Translation:AnimalsCells
  57. Sasaki Y, Ohta M, Desai D, Figueiredo JL, Whelan MC, Sugano T, Yamabi M, Yano W, Faits T, Yabusaki K, Zhang H, Mlynarchik AK, Inoue K, Mizuno K, Aikawa M. Angiopoietin Like Protein 2 (ANGPTL2) Promotes Adipose Tissue Macrophage and T lymphocyte Accumulation and Leads to Insulin Resistance. PLoS One. 2015; 10(7):e0131176. PMID: 26132105.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  58. Miyosawa K, Watanabe Y, Murakami K, Murakami T, Shibata H, Iwashita M, Yamazaki H, Yamazaki K, Ohgiya T, Shibuya K, Mizuno K, Tanabe S, Singh SA, Aikawa M. New CETP inhibitor K-312 reduces PCSK9 expression: a potential effect on LDL cholesterol metabolism. Am J Physiol Endocrinol Metab. 2015 Jul 15; 309(2):E177-90. PMID: 26015437.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  59. Lei Y, Iwashita M, Choi J, Aikawa M, Aikawa E. N-acetylglucosamine-1-Phosphate Transferase Suppresses Lysosomal Hydrolases in Dysfunctional Osteoclasts: A Potential Mechanism for Vascular Calcification. J Cardiovasc Dev Dis. 2015 Apr 15; 2(2):31-47. PMID: 29371511.
    Citations: 1     
  60. Lu H, Aikawa M. Many faces of matrix metalloproteinases in aortic aneurysms. Arterioscler Thromb Vasc Biol. 2015 Apr; 35(4):752-4. PMID: 25810296.
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  61. Figueiredo JL, Aikawa M, Zheng C, Aaron J, Lax L, Libby P, de Lima Filho JL, Gruener S, Fingerle J, Haap W, Hartmann G, Aikawa E. Selective cathepsin S inhibition attenuates atherosclerosis in apolipoprotein E-deficient mice with chronic renal disease. Am J Pathol. 2015 Apr; 185(4):1156-66. PMID: 25680278.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  62. Hutcheson JD, Goettsch C, Pham T, Iwashita M, Aikawa M, Singh SA, Aikawa E. Enrichment of calcifying extracellular vesicles using density-based ultracentrifugation protocol. J Extracell Vesicles. 2014; 3:25129. PMID: 25491249.
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  63. Takase K, Aikawa M, Okada K, Watanabe Y, Okamoto K, Sato H, Nonaka K, Yamaguchi S, Sakuramoto S, Koyama I, Miyazawa M. Development of novel treatment with a bioabsorbable esophageal patch for benign esophageal stricture. Dis Esophagus. 2015 Nov-Dec; 28(8):728-34. PMID: 25286827.
    Citations: 2     Fields:    Translation:Animals
  64. Miyazaki T, Chiuve S, Sacks FM, Ridker PM, Libby P, Aikawa M. Plasma pentraxin 3 levels do not predict coronary events but reflect metabolic disorders in patients with coronary artery disease in the CARE trial. PLoS One. 2014; 9(4):e94073. PMID: 24705587.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  65. Yabusaki K, Faits T, McMullen E, Figueiredo JL, Aikawa M, Aikawa E. A novel quantitative approach for eliminating sample-to-sample variation using a hue saturation value analysis program. PLoS One. 2014; 9(3):e89627. PMID: 24595280.
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  66. Koga J, Aikawa M. Application of anti-ligand antibodies to inhibit Notch signaling. Methods Mol Biol. 2014; 1187:335-42. PMID: 25053501.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  67. Itou T, Maldonado N, Yamada I, Goettsch C, Matsumoto J, Aikawa M, Singh S, Aikawa E. Cystathionine ?-lyase accelerates osteoclast differentiation: identification of a novel regulator of osteoclastogenesis by proteomic analysis. Arterioscler Thromb Vasc Biol. 2014 Mar; 34(3):626-34. PMID: 24357058.
    Citations: 9     Fields:    Translation:AnimalsCells
  68. Fukuda D, Aikawa M. Expanding role of delta-like 4 mediated notch signaling in cardiovascular and metabolic diseases. Circ J. 2013; 77(10):2462-8. PMID: 24025398.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  69. Wang JG, Aikawa E, Aikawa M. Leukocyte-derived microparticles as proinflammatory mediators in atherosclerosis. J Am Coll Cardiol. 2013 Oct 15; 62(16):1442-5. PMID: 23707315.
    Citations: 3     Fields:    Translation:HumansCells
  70. Zheng C, Morishige K, Aikawa M. Functional molecular imaging linking macrophages to reverse cholesterol transport. Circ J. 2013; 77(6):1403-6. PMID: 23685734.
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  71. New SE, Goettsch C, Aikawa M, Marchini JF, Shibasaki M, Yabusaki K, Libby P, Shanahan CM, Croce K, Aikawa E. Macrophage-derived matrix vesicles: an alternative novel mechanism for microcalcification in atherosclerotic plaques. Circ Res. 2013 Jun 21; 113(1):72-7. PMID: 23616621.
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  72. Iwata H, Aikawa M. Liver-artery interactions via the plasminogen-CD36 axis in macrophage foam cell formation: new evidence for the role of remote organ crosstalk in atherosclerosis. Circulation. 2013 Mar 19; 127(11):1173-6. PMID: 23509031.
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  73. Abe J, Manabe I, Aikawa M, Aikawa E. Cardiovascular Inflammation 2012: Reactive Oxygen Species, SUMOylation, and Biomarkers in Cardiovascular Inflammation. Int J Inflam. 2013; 2013:953463. PMID: 23555068.
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  74. Zheng C, Aikawa M. High-density lipoproteins: from function to therapy. J Am Coll Cardiol. 2012 Dec 11; 60(23):2380-3. PMID: 2