Harvard Catalyst Profiles

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Umut Ozcan, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK098496 (OZCAN, UMUT) Jun 18, 2013 - May 31, 2023
    Endoplasmic Reticulum Stress, Brain and Obesity
    Role: Principal Investigator
  2. R56DK098496 (OZCAN, UMUT) Jun 18, 2013 - Jul 31, 2019
    Endoplasmic Reticulum Stress, Brain and Obesity
    Role: Principal Investigator
  3. R56DK089111 (OZCAN, UMUT) Jun 1, 2011 - May 31, 2012
    ER Stress, Insulin Signaling and Metabolism
    Role: Principal Investigator
  4. R01DK081009 (OZCAN, UMUT) Mar 1, 2008 - Dec 31, 2013
    The In Vivo Role of JNK-1 and IRS-1 Ser307 Phosphorylation In Development of Insu
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Herrema H, Guan D, Choi JW, Feng X, Salazar Hernandez MA, Faruk F, Auen T, Boudett E, Tao R, Chun H, Ozcan U. FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity. Cell Metab. 2022 07 05; 34(7):1004-1022.e8. PMID: 35793654.
    Citations:    Fields:    Translation:AnimalsCells
  2. Ozcan U. Antisense-mediated senseful regulation of orchestrated metabolic response. Cell Chem Biol. 2022 04 21; 29(4):539-540. PMID: 35452620.
    Citations:    Fields:    Translation:Humans
  3. El Manaa W, Duplan E, Goiran T, Lauritzen I, Vaillant Beuchot L, Lacas-Gervais S, Morais VA, You H, Qi L, Salazar M, Ozcan U, Chami M, Checler F, Alves da Costa C. Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology. Autophagy. 2021 12; 17(12):4363-4385. PMID: 34030589; PMCID: PMC8726674.
    Citations: 3     Fields:    Translation:AnimalsCells
  4. Gao P, Li L, Yang L, Gui D, Zhang J, Han J, Wang J, Wang N, Lu J, Chen S, Hou L, Sun H, Xie L, Zhou J, Peng C, Lu Y, Peng X, Wang C, Miao J, Ozcan U, Huang Y, Jia W, Liu J. Yin Yang 1 protein ameliorates diabetic nephropathy pathology through transcriptional repression of TGFß1. Sci Transl Med. 2019 09 18; 11(510). PMID: 31534017.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  5. Feng X, Guan D, Auen T, Choi JW, Salazar-Hernandez MA, Faruk F, Copps KD, Ozcan U. Lipocalin 2 Does Not Play A Role in Celastrol-Mediated Reduction in Food Intake and Body Weight. Sci Rep. 2019 09 05; 9(1):12809. PMID: 31488870; PMCID: PMC6728323.
    Citations: 2     Fields:    Translation:Animals
  6. Feng X, Guan D, Auen T, Choi JW, Salazar Hernández MA, Lee J, Chun H, Faruk F, Kaplun E, Herbert Z, Copps KD, Ozcan U. IL1R1 is required for celastrol's leptin-sensitization and antiobesity effects. Nat Med. 2019 04; 25(4):575-582. PMID: 30833749; PMCID: PMC7158951.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  7. Lee J, Salazar Hernández MA, Auen T, Mucka P, Lee J, Ozcan U. PGC-1a functions as a co-suppressor of XBP1s to regulate glucose metabolism. Mol Metab. 2018 01; 7:119-131. PMID: 29129613.
    Citations: 11     Fields:    Translation:AnimalsCells
  8. Sharabi K, Lin H, Tavares CDJ, Dominy JE, Camporez JP, Perry RJ, Schilling R, Rines AK, Lee J, Hickey M, Bennion M, Palmer M, Nag PP, Bittker JA, Perez J, Jedrychowski MP, Ozcan U, Gygi SP, Kamenecka TM, Shulman GI, Schreiber SL, Griffin PR, Puigserver P. Selective Chemical Inhibition of PGC-1a Gluconeogenic Activity Ameliorates Type 2 Diabetes. Cell. 2017 03 23; 169(1):148-160.e15. PMID: 28340340.
    Citations: 60     Fields:    Translation:AnimalsCells
  9. Liu J, Ibi D, Taniguchi K, Lee J, Herrema H, Akosman B, Mucka P, Salazar Hernandez MA, Uyar MF, Park SW, Karin M, Ozcan U. Inflammation Improves Glucose Homeostasis through IKKß-XBP1s Interaction. Cell. 2016 11 03; 167(4):1052-1066.e18. PMID: 27814504; PMCID: PMC5908236.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  10. Lee J, Liu J, Feng X, Salazar Hernández MA, Mucka P, Ibi D, Choi JW, Ozcan U. Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice. Nat Med. 2016 09; 22(9):1023-32. PMID: 27479085; PMCID: PMC5892415.
    Citations: 66     Fields:    Translation:AnimalsCells
  11. Herrema H, Zhou Y, Zhang D, Lee J, Salazar Hernandez MA, Shulman GI, Ozcan U. XBP1s Is an Anti-lipogenic Protein. J Biol Chem. 2016 08 12; 291(33):17394-404. PMID: 27325692.
    Citations: 32     Fields:    Translation:AnimalsCells
  12. Liu J, Lee J, Salazar Hernandez MA, Mazitschek R, Ozcan U. Treatment of obesity with celastrol. Cell. 2015 May 21; 161(5):999-1011. PMID: 26000480; PMCID: PMC4768733.
    Citations: 210     Fields:    Translation:Animals
  13. Park SW, Herrema H, Salazar M, Cakir I, Cabi S, Basibuyuk Sahin F, Chiu YH, Cantley LC, Ozcan U. BRD7 regulates XBP1s' activity and glucose homeostasis through its interaction with the regulatory subunits of PI3K. Cell Metab. 2014 Jul 01; 20(1):73-84. PMID: 24836559.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  14. Cakir I, Ozcan U. Mom's milk molds neural wiring for metabolism. Cell. 2014 Jan 30; 156(3):396-7. PMID: 24485448.
    Citations:    Fields:    Translation:Animals
  15. Herrema H, Lee J, Zhou Y, Copps KD, White MF, Ozcan U. IRS1Ser³°7 phosphorylation does not mediate mTORC1-induced insulin resistance. Biochem Biophys Res Commun. 2014 Jan 10; 443(2):689-93. PMID: 24333417; PMCID: PMC3926104.
    Citations: 6     Fields:    Translation:AnimalsCells
  16. Lee J, Ozcan U. Unfolded protein response signaling and metabolic diseases. J Biol Chem. 2014 Jan 17; 289(3):1203-11. PMID: 24324257.
    Citations: 127     Fields:    Translation:HumansAnimalsCells
  17. Ozcan U. Mitofusins: mighty regulators of metabolism. Cell. 2013 Sep 26; 155(1):17-8. PMID: 24074856.
    Citations: 6     Fields:    Translation:AnimalsCells
  18. Park SW, Ozcan U. Potential for therapeutic manipulation of the UPR in disease. Semin Immunopathol. 2013 May; 35(3):351-73. PMID: 23572207.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  19. Sharara-Chami RI, Zhou Y, Ebert S, Pacak K, Ozcan U, Majzoub JA. Epinephrine deficiency results in intact glucose counter-regulation, severe hepatic steatosis and possible defective autophagy in fasting mice. Int J Biochem Cell Biol. 2012 Jun; 44(6):905-13. PMID: 22405854.
    Citations: 8     Fields:    Translation:AnimalsCells
  20. Lee J, Sun C, Zhou Y, Lee J, Gokalp D, Herrema H, Park SW, Davis RJ, Ozcan U. p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis. Nat Med. 2011 Sep 04; 17(10):1251-60. PMID: 21892182.
    Citations: 95     Fields:    Translation:HumansAnimalsCells
  21. Zhou Y, Lee J, Reno CM, Sun C, Park SW, Chung J, Lee J, Fisher SJ, White MF, Biddinger SB, Ozcan U. Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction. Nat Med. 2011 Mar; 17(3):356-65. PMID: 21317886.
    Citations: 141     Fields:    Translation:AnimalsCells
  22. Park SW, Zhou Y, Lee J, Lee J, Ozcan U. Sarco(endo)plasmic reticulum Ca2+-ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity. Proc Natl Acad Sci U S A. 2010 Nov 09; 107(45):19320-5. PMID: 20974941.
    Citations: 89     Fields:    Translation:AnimalsCells
  23. Park SW, Zhou Y, Lee J, Lu A, Sun C, Chung J, Ueki K, Ozcan U. The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation. Nat Med. 2010 Apr; 16(4):429-37. PMID: 20348926.
    Citations: 147     Fields:    Translation:AnimalsCells
  24. Ozcan L, Ergin AS, Lu A, Chung J, Sarkar S, Nie D, Myers MG, Ozcan U. Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metab. 2009 Jan 07; 9(1):35-51. PMID: 19117545.
    Citations: 360     Fields:    Translation:AnimalsCells
  25. Ozcan U, Ozcan L, Yilmaz E, Düvel K, Sahin M, Manning BD, Hotamisligil GS. Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol Cell. 2008 Mar 14; 29(5):541-51. PMID: 18342602; PMCID: PMC2361721.
    Citations: 230     Fields:    Translation:HumansAnimalsCells
  26. Pissios P, Ozcan U, Kokkotou E, Okada T, Liew CW, Liu S, Peters JN, Dahlgren G, Karamchandani J, Kudva YC, Kurpad AJ, Kennedy RT, Maratos-Flier E, Kulkarni RN. Melanin concentrating hormone is a novel regulator of islet function and growth. Diabetes. 2007 Feb; 56(2):311-9. PMID: 17259374.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  27. Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, Görgün CZ, Hotamisligil GS. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science. 2006 Aug 25; 313(5790):1137-40. PMID: 16931765; PMCID: PMC4741373.
    Citations: 1061     Fields:    Translation:AnimalsCells
  28. Hennige AM, Ozcan U, Okada T, Jhala US, Schubert M, White MF, Kulkarni RN. Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells. Am J Physiol Endocrinol Metab. 2005 Aug; 289(2):E337-46. PMID: 15827066.
    Citations: 12     Fields:    Translation:AnimalsCells
  29. Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Görgün C, Glimcher LH, Hotamisligil GS. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science. 2004 Oct 15; 306(5695):457-61. PMID: 15486293.
    Citations: 1463     Fields:    Translation:AnimalsCells
  30. Hennige AM, Burks DJ, Ozcan U, Kulkarni RN, Ye J, Park S, Schubert M, Fisher TL, Dow MA, Leshan R, Zakaria M, Mossa-Basha M, White MF. Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes. J Clin Invest. 2003 Nov; 112(10):1521-32. PMID: 14617753; PMCID: PMC259126.
    Citations: 82     Fields:    Translation:HumansAnimalsCells
  31. Rosen ED, Kulkarni RN, Sarraf P, Ozcan U, Okada T, Hsu CH, Eisenman D, Magnuson MA, Gonzalez FJ, Kahn CR, Spiegelman BM. Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Mol Cell Biol. 2003 Oct; 23(20):7222-9. PMID: 14517292.
    Citations: 69     Fields:    Translation:Animals
  32. Kulkarni RN, Holzenberger M, Shih DQ, Ozcan U, Stoffel M, Magnuson MA, Kahn CR. beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. Nat Genet. 2002 May; 31(1):111-5. PMID: 11923875.
    Citations: 143     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.