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Nikolaos Patsoukis, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Mahoney KM, Shukla SA, Patsoukis N, Chaudhri A, Browne EP, Arazi A, Eisenhaure TM, Pendergraft WF, Hua P, Pham HC, Bu X, Zhu B, Hacohen N, Fritsch EF, Boussiotis VA, Wu CJ, Freeman GJ. A secreted PD-L1 splice variant that covalently dimerizes and mediates immunosuppression. Cancer Immunol Immunother. 2019 Mar; 68(3):421-432. PMID: 30564891.
    Citations:    Fields:    
  2. Yazicioglu YF, Aksoylar HI, Pal R, Patsoukis N, Boussiotis VA. Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches. J Vis Exp. 2018 11 21; (141). PMID: 30531720.
    Citations:    Fields:    
  3. Strauss L, Patsoukis N, Boussiotis VA. Publisher Correction: Feeling stressed? It might be your T cells. Nat Immunol. 2018 Sep; 19(9):1037. PMID: 29955108.
    Citations:    Fields:    
  4. Le Bourgeois T, Strauss L, Aksoylar HI, Daneshmandi S, Seth P, Patsoukis N, Boussiotis VA. Targeting T Cell Metabolism for Improvement of Cancer Immunotherapy. Front Oncol. 2018; 8:237. PMID: 30123774.
    Citations:    
  5. Strauss L, Patsoukis N, Boussiotis VA. Feeling stressed? It might be your T cells. Nat Immunol. 2017 11 16; 18(12):1281-1283. PMID: 29144505.
    Citations:    Fields:    
  6. Patsoukis N, Bardhan K, Weaver JD, Sari D, Torres-Gomez A, Li L, Strauss L, Lafuente EM, Boussiotis VA. The adaptor molecule RIAM integrates signaling events critical for integrin-mediated control of immune function and cancer progression. Sci Signal. 2017 Aug 22; 10(493). PMID: 28831022.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  7. Patsoukis N, Weaver JD, Strauss L, Herbel C, Seth P, Boussiotis VA. Immunometabolic Regulations Mediated by Coinhibitory Receptors and Their Impact on T Cell Immune Responses. Front Immunol. 2017; 8:330. PMID: 28443090.
    Citations: 4     
  8. Herbel C, Patsoukis N, Bardhan K, Seth P, Weaver JD, Boussiotis VA. Clinical significance of T cell metabolic reprogramming in cancer. Clin Transl Med. 2016 Dec; 5(1):29. PMID: 27510264.
    Citations: 10     
  9. Patsoukis N, Bardhan K, Weaver J, Herbel C, Seth P, Li L, Boussiotis VA. The role of metabolic reprogramming in T cell fate and function. Curr Trends Immunol. 2016; 17:1-12. PMID: 28356677.
    Citations: 5     
  10. Patsoukis N, Bardhan K, Chatterjee P, Sari D, Liu B, Bell LN, Karoly ED, Freeman GJ, Petkova V, Seth P, Li L, Boussiotis VA. PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation. Nat Commun. 2015 Mar 26; 6:6692. PMID: 25809635.
    Citations: 104     Fields:    Translation:HumansCells
  11. Nellore A, Liu B, Patsoukis N, Boussiotis VA, Li L. The cyclin dependent kinase inhibitor (R)-roscovitine mediates selective suppression of alloreactive human T cells but preserves pathogen-specific and leukemia-specific effectors. Clin Immunol. 2014 May-Jun; 152(1-2):48-57. PMID: 24631965.
    Citations: 3     Fields:    Translation:HumansCells
  12. Li L, Kim HT, Nellore A, Patsoukis N, Petkova V, McDonough S, Politikos I, Nikiforow S, Soiffer R, Antin JH, Ballen K, Cutler C, Ritz J, Boussiotis VA. Prostaglandin E2 promotes survival of naive UCB T cells via the Wnt/ß-catenin pathway and alters immune reconstitution after UCBT. Blood Cancer J. 2014 Jan 17; 4:e178. PMID: 24442207.
    Citations: 12     Fields:    
  13. Patsoukis N, Li L, Sari D, Petkova V, Boussiotis VA. PD-1 increases PTEN phosphatase activity while decreasing PTEN protein stability by inhibiting casein kinase 2. Mol Cell Biol. 2013 Aug; 33(16):3091-8. PMID: 23732914.
    Citations: 38     Fields:    Translation:HumansCells
  14. Wynne JP, Wu J, Su W, Mor A, Patsoukis N, Boussiotis VA, Hubbard SR, Philips MR. Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector. J Cell Biol. 2012 Oct 15; 199(2):317-30. PMID: 23045549.
    Citations: 18     Fields:    Translation:HumansCells
  15. Patsoukis N, Sari D, Boussiotis VA. PD-1 inhibits T cell proliferation by upregulating p27 and p15 and suppressing Cdc25A. Cell Cycle. 2012 Dec 01; 11(23):4305-9. PMID: 23032366.
    Citations: 34     Fields:    Translation:HumansCells
  16. Li L, Patsoukis N, Petkova V, Boussiotis VA. Runx1 and Runx3 are involved in the generation and function of highly suppressive IL-17-producing T regulatory cells. PLoS One. 2012; 7(9):e45115. PMID: 22984619.
    Citations: 11     Fields:    Translation:AnimalsCells
  17. Patsoukis N, Brown J, Petkova V, Liu F, Li L, Boussiotis VA. Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation. Sci Signal. 2012 Jun 26; 5(230):ra46. PMID: 22740686.
    Citations: 94     Fields:    Translation:HumansCells
  18. Patsoukis N, Lafuente EM, Meraner P, Kim Js, Dombkowski D, Li L, Boussiotis VA. RIAM regulates the cytoskeletal distribution and activation of PLC-gamma1 in T cells. Sci Signal. 2009 Dec 01; 2(99):ra79. PMID: 19952372.
    Citations: 8     Fields:    Translation:HumansCells
  19. Patsoukis N, Georgiou CD. Differentiation of Sclerotinia minor depends on thiol redox state and oxidative stress. Can J Microbiol. 2008 Jan; 54(1):28-36. PMID: 18388969.
    Citations: 3     Fields:    Translation:AnimalsCells
  20. Patsoukis N, Georgiou DC. Thiol redox state and related enzymes in sclerotium-forming filamentous phytopathogenic fungi. Mycol Res. 2008 May; 112(Pt 5):602-10. PMID: 18400483.
    Citations: 3     Fields:    Translation:AnimalsCells
  21. Assimakopoulos SF, Maroulis I, Patsoukis N, Vagenas K, Scopa CD, Georgiou CD, Vagianos CE. Effect of antioxidant treatments on the gut-liver axis oxidative status and function in bile duct-ligated rats. World J Surg. 2007 Oct; 31(10):2023-32. PMID: 17665241.
    Citations: 5     Fields:    Translation:AnimalsCells
  22. Patsoukis N, Georgiou CD. Effect of thiol redox state modulators on oxidative stress and sclerotial differentiation of the phytopathogenic fungus Rhizoctonia solani. Arch Microbiol. 2007 Sep; 188(3):225-33. PMID: 17429612.
    Citations: 5     Fields:    Translation:AnimalsCells
  23. Patsoukis N, Georgiou CD. Effect of glutathione biosynthesis-related modulators on the thiol redox state enzymes and on sclerotial differentiation of filamentous phytopathogenic fungi. Mycopathologia. 2007 Jun; 163(6):335-47. PMID: 17387631.
    Citations: 3     Fields:    Translation:AnimalsCells
  24. Gartaganis SP, Patsoukis NE, Nikolopoulos DK, Georgiou CD. Evidence for oxidative stress in lens epithelial cells in pseudoexfoliation syndrome. Eye (Lond). 2007 Nov; 21(11):1406-11. PMID: 17001325.
    Citations: 13     Fields:    Translation:HumansCells
  25. Karageorgos N, Patsoukis N, Chroni E, Konstantinou D, Assimakopoulos SF, Georgiou C. Effect of N-acetylcysteine, allopurinol and vitamin E on jaundice-induced brain oxidative stress in rats. Brain Res. 2006 Sep 21; 1111(1):203-12. PMID: 16884703.
    Citations: 9     Fields:    Translation:AnimalsCells
  26. Georgiou CD, Patsoukis N, Papapostolou I, Zervoudakis G. Sclerotial metamorphosis in filamentous fungi is induced by oxidative stress. Integr Comp Biol. 2006 Dec; 46(6):691-712. PMID: 21672779.
    Citations: 26     Fields:    
  27. Konstantinidis TC, Patsoukis N, Georgiou CD, Synetos D. Translational fidelity mutations in 18S rRNA affect the catalytic activity of ribosomes and the oxidative balance of yeast cells. Biochemistry. 2006 Mar 21; 45(11):3525-33. PMID: 16533033.
    Citations: 6     Fields:    Translation:AnimalsCells
  28. Chroni E, Patsoukis N, Karageorgos N, Konstantinou D, Georgiou C. Brain oxidative stress induced by obstructive jaundice in rats. J Neuropathol Exp Neurol. 2006 Feb; 65(2):193-8. PMID: 16462210.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  29. Patsoukis N, Georgiou CD. Fluorometric determination of thiol redox state. Anal Bioanal Chem. 2005 Nov; 383(6):923-9. PMID: 16261319.
    Citations: 7     Fields:    Translation:Cells
  30. Georgiou CD, Papapostolou I, Patsoukis N, Tsegenidis T, Sideris T. An ultrasensitive fluorescent assay for the in vivo quantification of superoxide radical in organisms. Anal Biochem. 2005 Dec 01; 347(1):144-51. PMID: 16246291.
    Citations: 14     Fields:    Translation:HumansAnimals
  31. Patsoukis N, Zervoudakis G, Georgiou CD, Angelatou F, Matsokis NA, Panagopoulos NT. Thiol redox state and lipid and protein oxidation in the mouse striatum after pentylenetetrazol-induced epileptic seizure. Epilepsia. 2005 Aug; 46(8):1205-11. PMID: 16060929.
    Citations: 4     Fields:    Translation:AnimalsCells
  32. Gartaganis SP, Georgakopoulos CD, Patsoukis NE, Gotsis SS, Gartaganis VS, Georgiou CD. Glutathione and lipid peroxide changes in pseudoexfoliation syndrome. Curr Eye Res. 2005 Aug; 30(8):647-51. PMID: 16109644.
    Citations: 10     Fields:    Translation:HumansCells
  33. Georgiou CD, Patsoukis N, Papapostolou I. Assay for the quantification of small-sized fragmented genomic DNA. Anal Biochem. 2005 Apr 15; 339(2):223-30. PMID: 15797562.
    Citations: 4     Fields:    Translation:Cells
  34. Patsoukis N, Papapostolou I, Georgiou CD. Interference of non-specific peroxidases in the fluorescence detection of superoxide radical by hydroethidine oxidation: a new assay for H2O2. Anal Bioanal Chem. 2005 Mar; 381(5):1065-72. PMID: 15690180.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  35. Patsoukis N, Papapostolou I, Zervoudakis G, Georgiou CD, Matsokis NA, Panagopoulos NT. Thiol redox state and oxidative stress in midbrain and striatum of weaver mutant mice, a genetic model of nigrostriatal dopamine deficiency. Neurosci Lett. 2005 Mar 07; 376(1):24-8. PMID: 15694268.
    Citations: 5     Fields:    Translation:AnimalsCells
  36. Patsoukis N, Zervoudakis G, Georgiou CD, Angelatou F, Matsokis NA, Panagopoulos NT. Effect of pentylenetetrazol-induced epileptic seizure on thiol redox state in the mouse cerebral cortex. Epilepsy Res. 2004 Nov; 62(1):65-74. PMID: 15519133.
    Citations: 6     Fields:    Translation:AnimalsCells
  37. Papapostolou I, Patsoukis N, Georgiou CD. The fluorescence detection of superoxide radical using hydroethidine could be complicated by the presence of heme proteins. Anal Biochem. 2004 Sep 15; 332(2):290-8. PMID: 15325298.
    Citations: 11     Fields:    Translation:AnimalsCells
  38. Alexandris IH, Assimakopoulos SF, Vagianos CE, Patsoukis N, Georgiou C, Nikolopoulou V, Scopa CD. Oxidative state in intestine and liver after partial hepatectomy in rats. Effect of bombesin and neurotensin. Clin Biochem. 2004 May; 37(5):350-6. PMID: 15087249.
    Citations: 9     Fields:    Translation:AnimalsCells
  39. Patsoukis N, Zervoudakis G, Panagopoulos NT, Georgiou CD, Angelatou F, Matsokis NA. Thiol redox state (TRS) and oxidative stress in the mouse hippocampus after pentylenetetrazol-induced epileptic seizure. Neurosci Lett. 2004 Mar 04; 357(2):83-6. PMID: 15036580.
    Citations: 24     Fields:    Translation:AnimalsCells
  40. Patsoukis N, Georgiou CD. Determination of the thiol redox state of organisms: new oxidative stress indicators. Anal Bioanal Chem. 2004 Apr; 378(7):1783-92. PMID: 14985909.
    Citations: 15     Fields:    Translation:AnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.