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Nikolaos Patsoukis, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Christofides A, Katopodi XL, Cao C, Karagkouni D, Aliazis K, Yenyuwadee S, Aksoylar HI, Pal R, Mahmoud MAA, Strauss L, Tijaro-Ovalle NM, Boon L, Asara J, Vlachos IS, Patsoukis N, Boussiotis VA. SHP-2 and PD-1-SHP-2 signaling regulate myeloid cell differentiation and antitumor responses. Nat Immunol. 2023 01; 24(1):55-68. PMID: 36581713; PMCID: PMC9810534.
    Citations:    Fields:    Translation:AnimalsCells
  2. Patsoukis N, Boussiotis VA. PTEN checkMAITs type-17 innate-like T cells. Nat Cell Biol. 2022 11; 24(11):1565-1567. PMID: 36302968.
    Citations:    Fields:    Translation:Cells
  3. Yenyuwadee S, Aliazis K, Wang Q, Christofides A, Shah R, Patsoukis N, Boussiotis VA. Immune cellular components and signaling pathways in the tumor microenvironment. Semin Cancer Biol. 2022 11; 86(Pt 2):187-201. PMID: 35985559.
    Citations: 3     Fields:    Translation:HumansCells
  4. Aksoylar HI, Patsoukis N. Treatment with Exogenously Added Catalase Alters CD8 T Cell Memory Differentiation and Function. Adv Biol (Weinh). 2022 Apr 28; e2101320. PMID: 35481698; PMCID: PMC9613814.
    Citations:    Fields:    
  5. Boussiotis VA, Patsoukis N. Effects of PD-1 Signaling on Immunometabolic Reprogramming. Immunometabolism. 2022; 4(2). PMID: 35371563; PMCID: PMC8975241.
  6. Sari-Ak D, Torres-Gomez A, Yazicioglu YF, Christofides A, Patsoukis N, Lafuente EM, Boussiotis VA. Structural, biochemical, and functional properties of the Rap1-Interacting Adaptor Molecule (RIAM). Biomed J. 2022 04; 45(2):289-298. PMID: 34601137; PMCID: PMC9250098.
    Citations: 2     Fields:    Translation:HumansCells
  7. Wang Q, Bardhan K, Boussiotis VA, Patsoukis N. The PD-1 Interactome. Adv Biol (Weinh). 2021 09; 5(9):e2100758. PMID: 34170628.
    Citations: 5     Fields:    Translation:HumansCells
  8. Bardhan K, Aksoylar HI, Le Bourgeois T, Strauss L, Weaver JD, Delcuze B, Charest A, Patsoukis N, Boussiotis VA. Publisher Correction: Phosphorylation of PD-1-Y248 is a marker of PD-1-mediated inhibitory function in human T cells. Sci Rep. 2020 Sep 23; 10(1):15905. PMID: 32963251.
    Citations:    Fields:    
  9. Patsoukis N, Wang Q, Strauss L, Boussiotis VA. Revisiting the PD-1 pathway. Sci Adv. 2020 09; 6(38). PMID: 32948597; PMCID: PMC7500922.
    Citations: 73     Fields:    
  10. Aksoylar HI, Tijaro-Ovalle NM, Boussiotis VA, Patsoukis N. T Cell Metabolism in Cancer Immunotherapy. Immunometabolism. 2020; 2(3). PMID: 32642279; PMCID: PMC7341973.
    Citations: 6     
  11. Patsoukis N, Duke-Cohan JS, Chaudhri A, Aksoylar HI, Wang Q, Council A, Berg A, Freeman GJ, Boussiotis VA. Interaction of SHP-2 SH2 domains with PD-1 ITSM induces PD-1 dimerization and SHP-2 activation. Commun Biol. 2020 03 17; 3(1):128. PMID: 32184441.
    Citations: 31     Translation:HumansAnimalsCells
  12. Strauss L, Mahmoud MAA, Weaver JD, Tijaro-Ovalle NM, Christofides A, Wang Q, Pal R, Yuan M, Asara J, Patsoukis N, Boussiotis VA. Targeted deletion of PD-1 in myeloid cells induces antitumor immunity. Sci Immunol. 2020 01 03; 5(43). PMID: 31901074.
    Citations: 107     Fields:    Translation:AnimalsCells
  13. Bardhan K, Aksoylar HI, Le Bourgeois T, Strauss L, Weaver JD, Delcuze B, Charest A, Patsoukis N, Boussiotis VA. Phosphorylation of PD-1-Y248 is a marker of PD-1-mediated inhibitory function in human T cells. Sci Rep. 2019 11 21; 9(1):17252. PMID: 31754127.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  14. Mahoney KM, Shukla SA, Patsoukis N, Chaudhri A, Browne EP, Arazi A, Eisenhaure TM, Pendergraft WF, Hua P, Pham HC, Bu X, Zhu B, Hacohen N, Fritsch EF, Boussiotis VA, Wu CJ, Freeman GJ. A secreted PD-L1 splice variant that covalently dimerizes and mediates immunosuppression. Cancer Immunol Immunother. 2019 Mar; 68(3):421-432. PMID: 30564891.
    Citations: 39     Fields:    Translation:HumansCells
  15. Yazicioglu YF, Aksoylar HI, Pal R, Patsoukis N, Boussiotis VA. Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches. J Vis Exp. 2018 11 21; (141). PMID: 30531720.
    Citations:    Fields:    Translation:AnimalsCells
  16. Strauss L, Patsoukis N, Boussiotis VA. Publisher Correction: Feeling stressed? It might be your T cells. Nat Immunol. 2018 Sep; 19(9):1037. PMID: 29955108.
    Citations:    Fields:    
  17. Le Bourgeois T, Strauss L, Aksoylar HI, Daneshmandi S, Seth P, Patsoukis N, Boussiotis VA. Targeting T Cell Metabolism for Improvement of Cancer Immunotherapy. Front Oncol. 2018; 8:237. PMID: 30123774; PMCID: PMC6085483.
    Citations: 57     
  18. Strauss L, Patsoukis N, Boussiotis VA. Feeling stressed? It might be your T cells. Nat Immunol. 2017 11 16; 18(12):1281-1283. PMID: 29144505.
    Citations: 1     Fields:    Translation:AnimalsCells
  19. Patsoukis N, Bardhan K, Weaver JD, Sari D, Torres-Gomez A, Li L, Strauss L, Lafuente EM, Boussiotis VA. The adaptor molecule RIAM integrates signaling events critical for integrin-mediated control of immune function and cancer progression. Sci Signal. 2017 Aug 22; 10(493). PMID: 28831022.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  20. Patsoukis N, Weaver JD, Strauss L, Herbel C, Seth P, Boussiotis VA. Immunometabolic Regulations Mediated by Coinhibitory Receptors and Their Impact on T Cell Immune Responses. Front Immunol. 2017; 8:330. PMID: 28443090; PMCID: PMC5387055.
    Citations: 26     Fields:    
  21. Herbel C, Patsoukis N, Bardhan K, Seth P, Weaver JD, Boussiotis VA. Clinical significance of T cell metabolic reprogramming in cancer. Clin Transl Med. 2016 Dec; 5(1):29. PMID: 27510264; PMCID: PMC4980327.
    Citations: 38     Fields:    
  22. Patsoukis N, Bardhan K, Weaver J, Herbel C, Seth P, Li L, Boussiotis VA. The role of metabolic reprogramming in T cell fate and function. Curr Trends Immunol. 2016; 17:1-12. PMID: 28356677; PMCID: PMC5367635.
    Citations: 21     
  23. Patsoukis N, Bardhan K, Chatterjee P, Sari D, Liu B, Bell LN, Karoly ED, Freeman GJ, Petkova V, Seth P, Li L, Boussiotis VA. PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation. Nat Commun. 2015 Mar 26; 6:6692. PMID: 25809635.
    Citations: 409     Fields:    Translation:HumansCells
  24. Nellore A, Liu B, Patsoukis N, Boussiotis VA, Li L. The cyclin dependent kinase inhibitor (R)-roscovitine mediates selective suppression of alloreactive human T cells but preserves pathogen-specific and leukemia-specific effectors. Clin Immunol. 2014 May-Jun; 152(1-2):48-57. PMID: 24631965.
    Citations: 5     Fields:    Translation:HumansCells
  25. Li L, Kim HT, Nellore A, Patsoukis N, Petkova V, McDonough S, Politikos I, Nikiforow S, Soiffer R, Antin JH, Ballen K, Cutler C, Ritz J, Boussiotis VA. Prostaglandin E2 promotes survival of naive UCB T cells via the Wnt/ß-catenin pathway and alters immune reconstitution after UCBT. Blood Cancer J. 2014 Jan 17; 4:e178. PMID: 24442207.
    Citations: 18     Fields:    
  26. Patsoukis N, Li L, Sari D, Petkova V, Boussiotis VA. PD-1 increases PTEN phosphatase activity while decreasing PTEN protein stability by inhibiting casein kinase 2. Mol Cell Biol. 2013 Aug; 33(16):3091-8. PMID: 23732914.
    Citations: 85     Fields:    Translation:HumansCells
  27. Wynne JP, Wu J, Su W, Mor A, Patsoukis N, Boussiotis VA, Hubbard SR, Philips MR. Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector. J Cell Biol. 2012 Oct 15; 199(2):317-30. PMID: 23045549.
    Citations: 34     Fields:    Translation:HumansCells
  28. Patsoukis N, Sari D, Boussiotis VA. PD-1 inhibits T cell proliferation by upregulating p27 and p15 and suppressing Cdc25A. Cell Cycle. 2012 Dec 01; 11(23):4305-9. PMID: 23032366.
    Citations: 61     Fields:    Translation:HumansCells
  29. Li L, Patsoukis N, Petkova V, Boussiotis VA. Runx1 and Runx3 are involved in the generation and function of highly suppressive IL-17-producing T regulatory cells. PLoS One. 2012; 7(9):e45115. PMID: 22984619.
    Citations: 17     Fields:    Translation:AnimalsCells
  30. Patsoukis N, Brown J, Petkova V, Liu F, Li L, Boussiotis VA. Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation. Sci Signal. 2012 Jun 26; 5(230):ra46. PMID: 22740686; PMCID: PMC5498435.
    Citations: 229     Fields:    Translation:HumansCells
  31. Patsoukis N, Lafuente EM, Meraner P, Kim Js, Dombkowski D, Li L, Boussiotis VA. RIAM regulates the cytoskeletal distribution and activation of PLC-gamma1 in T cells. Sci Signal. 2009 Dec 01; 2(99):ra79. PMID: 19952372.
    Citations: 16     Fields:    Translation:HumansCells
  32. Patsoukis N, Georgiou CD. Differentiation of Sclerotinia minor depends on thiol redox state and oxidative stress. Can J Microbiol. 2008 Jan; 54(1):28-36. PMID: 18388969.
    Citations: 3     Fields:    Translation:AnimalsCells
  33. Patsoukis N, Georgiou DC. Thiol redox state and related enzymes in sclerotium-forming filamentous phytopathogenic fungi. Mycol Res. 2008 May; 112(Pt 5):602-10. PMID: 18400483.
    Citations: 4     Fields:    Translation:AnimalsCells
  34. Assimakopoulos SF, Maroulis I, Patsoukis N, Vagenas K, Scopa CD, Georgiou CD, Vagianos CE. Effect of antioxidant treatments on the gut-liver axis oxidative status and function in bile duct-ligated rats. World J Surg. 2007 Oct; 31(10):2023-32. PMID: 17665241.
    Citations: 6     Fields:    Translation:AnimalsCells
  35. Patsoukis N, Georgiou CD. Effect of thiol redox state modulators on oxidative stress and sclerotial differentiation of the phytopathogenic fungus Rhizoctonia solani. Arch Microbiol. 2007 Sep; 188(3):225-33. PMID: 17429612.
    Citations: 5     Fields:    Translation:AnimalsCells
  36. Patsoukis N, Georgiou CD. Effect of glutathione biosynthesis-related modulators on the thiol redox state enzymes and on sclerotial differentiation of filamentous phytopathogenic fungi. Mycopathologia. 2007 Jun; 163(6):335-47. PMID: 17387631.
    Citations: 4     Fields:    Translation:AnimalsCells
  37. Gartaganis SP, Patsoukis NE, Nikolopoulos DK, Georgiou CD. Evidence for oxidative stress in lens epithelial cells in pseudoexfoliation syndrome. Eye (Lond). 2007 Nov; 21(11):1406-11. PMID: 17001325.
    Citations: 25     Fields:    Translation:HumansCells
  38. Karageorgos N, Patsoukis N, Chroni E, Konstantinou D, Assimakopoulos SF, Georgiou C. Effect of N-acetylcysteine, allopurinol and vitamin E on jaundice-induced brain oxidative stress in rats. Brain Res. 2006 Sep 21; 1111(1):203-12. PMID: 16884703.
    Citations: 12     Fields:    Translation:AnimalsCells
  39. Georgiou CD, Patsoukis N, Papapostolou I, Zervoudakis G. Sclerotial metamorphosis in filamentous fungi is induced by oxidative stress. Integr Comp Biol. 2006 Dec; 46(6):691-712. PMID: 21672779.
    Citations: 49     Fields:    
  40. Konstantinidis TC, Patsoukis N, Georgiou CD, Synetos D. Translational fidelity mutations in 18S rRNA affect the catalytic activity of ribosomes and the oxidative balance of yeast cells. Biochemistry. 2006 Mar 21; 45(11):3525-33. PMID: 16533033.
    Citations: 7     Fields:    Translation:AnimalsCells
  41. Chroni E, Patsoukis N, Karageorgos N, Konstantinou D, Georgiou C. Brain oxidative stress induced by obstructive jaundice in rats. J Neuropathol Exp Neurol. 2006 Feb; 65(2):193-8. PMID: 16462210.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  42. Patsoukis N, Georgiou CD. Fluorometric determination of thiol redox state. Anal Bioanal Chem. 2005 Nov; 383(6):923-9. PMID: 16261319.
    Citations: 9     Fields:    Translation:Cells
  43. Georgiou CD, Papapostolou I, Patsoukis N, Tsegenidis T, Sideris T. An ultrasensitive fluorescent assay for the in vivo quantification of superoxide radical in organisms. Anal Biochem. 2005 Dec 01; 347(1):144-51. PMID: 16246291.
    Citations: 19     Fields:    Translation:HumansAnimals
  44. Gartaganis SP, Georgakopoulos CD, Patsoukis NE, Gotsis SS, Gartaganis VS, Georgiou CD. Glutathione and lipid peroxide changes in pseudoexfoliation syndrome. Curr Eye Res. 2005 Aug; 30(8):647-51. PMID: 16109644.
    Citations: 16     Fields:    Translation:HumansCells
  45. Patsoukis N, Zervoudakis G, Georgiou CD, Angelatou F, Matsokis NA, Panagopoulos NT. Thiol redox state and lipid and protein oxidation in the mouse striatum after pentylenetetrazol-induced epileptic seizure. Epilepsia. 2005 Aug; 46(8):1205-11. PMID: 16060929.
    Citations: 9     Fields:    Translation:AnimalsCells
  46. Georgiou CD, Patsoukis N, Papapostolou I. Assay for the quantification of small-sized fragmented genomic DNA. Anal Biochem. 2005 Apr 15; 339(2):223-30. PMID: 15797562.
    Citations: 4     Fields:    Translation:Cells
  47. Patsoukis N, Papapostolou I, Georgiou CD. Interference of non-specific peroxidases in the fluorescence detection of superoxide radical by hydroethidine oxidation: a new assay for H2O2. Anal Bioanal Chem. 2005 Mar; 381(5):1065-72. PMID: 15690180.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  48. Patsoukis N, Papapostolou I, Zervoudakis G, Georgiou CD, Matsokis NA, Panagopoulos NT. Thiol redox state and oxidative stress in midbrain and striatum of weaver mutant mice, a genetic model of nigrostriatal dopamine deficiency. Neurosci Lett. 2005 Mar 07; 376(1):24-8. PMID: 15694268.
    Citations: 8     Fields:    Translation:AnimalsCells
  49. Patsoukis N, Zervoudakis G, Georgiou CD, Angelatou F, Matsokis NA, Panagopoulos NT. Effect of pentylenetetrazol-induced epileptic seizure on thiol redox state in the mouse cerebral cortex. Epilepsy Res. 2004 Nov; 62(1):65-74. PMID: 15519133.
    Citations: 8     Fields:    Translation:AnimalsCells
  50. Papapostolou I, Patsoukis N, Georgiou CD. The fluorescence detection of superoxide radical using hydroethidine could be complicated by the presence of heme proteins. Anal Biochem. 2004 Sep 15; 332(2):290-8. PMID: 15325298.
    Citations: 11     Fields:    Translation:AnimalsCells
  51. Alexandris IH, Assimakopoulos SF, Vagianos CE, Patsoukis N, Georgiou C, Nikolopoulou V, Scopa CD. Oxidative state in intestine and liver after partial hepatectomy in rats. Effect of bombesin and neurotensin. Clin Biochem. 2004 May; 37(5):350-6. PMID: 15087249.
    Citations: 9     Fields:    Translation:AnimalsCells
  52. Patsoukis N, Zervoudakis G, Panagopoulos NT, Georgiou CD, Angelatou F, Matsokis NA. Thiol redox state (TRS) and oxidative stress in the mouse hippocampus after pentylenetetrazol-induced epileptic seizure. Neurosci Lett. 2004 Mar 04; 357(2):83-6. PMID: 15036580.
    Citations: 49     Fields:    Translation:AnimalsCells
  53. Patsoukis N, Georgiou CD. Determination of the thiol redox state of organisms: new oxidative stress indicators. Anal Bioanal Chem. 2004 Apr; 378(7):1783-92. PMID: 14985909.
    Citations: 18     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.