Harvard Catalyst Profiles

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William Liang Hwang, M.D., Ph.D.

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AACR NextGen Star
2022 - 2027
Burroughs Wellcome Fund Career Award for Medical Scientists
Hopper-Belmont Foundation Inspiration Award
2020 - 2021
Andrew L. Warshaw, MD Institute for Pancreatic Cancer Research Fellow
ASCO Young Investigator Award
APA Young Investigator Travel Award
RSNA Research Resident Grant
Conquer Cancer Foundation Merit Award
First Place in Clinical Research (Massachusetts Medical Society)
William Shipley Research Award
Clinical Research Award (MGH Clinical Research Day)
Outstanding Resident Recognition (Harvard Medical School)
Resident Teaching Award in Medicine
Summa cum laude (Harvard Medical School)
Seidman Prize for Outstanding Senior Medical Student Thesis
2008 - 2010
Paul & Daisy Soros Fellow
2006 - 2008
Rhodes Scholar
2002 - 2006
Angier B. Duke Scholar

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Seldon CS, Meiyappan K, Hoffman H, Guo JA, Goel N, Hwang WL, Nguyen PL, Mahal BA, Alshalalfa M. Genomic alterations predictive of poor clinical outcomes in pan-cancer. Oncotarget. 2022; 13:1069-1077. PMID: 36187555; PMCID: PMC9518688.
    Citations:    Fields:    Translation:Humans
  2. Shiau C, Su J, Guo JA, Hong TS, Wo JY, Jagadeesh KA, Hwang WL. Treatment-associated remodeling of the pancreatic cancer endothelium at single-cell resolution. Front Oncol. 2022; 12:929950. PMID: 36185212; PMCID: PMC9524152.
  3. Hwang WL, Jagadeesh KA, Guo JA, Hoffman HI, Yadollahpour P, Reeves JW, Mohan R, Drokhlyansky E, Van Wittenberghe N, Ashenberg O, Farhi SL, Schapiro D, Divakar P, Miller E, Zollinger DR, Eng G, Schenkel JM, Su J, Shiau C, Yu P, Freed-Pastor WA, Abbondanza D, Mehta A, Gould J, Lambden C, Porter CBM, Tsankov A, Dionne D, Waldman J, Cuoco MS, Nguyen L, Delorey T, Phillips D, Barth JL, Kem M, Rodrigues C, Ciprani D, Roldan J, Zelga P, Jorgji V, Chen JH, Ely Z, Zhao D, Fuhrman K, Fropf R, Beechem JM, Loeffler JS, Ryan DP, Weekes CD, Ferrone CR, Qadan M, Aryee MJ, Jain RK, Neuberg DS, Wo JY, Hong TS, Xavier R, Aguirre AJ, Rozenblatt-Rosen O, Mino-Kenudson M, Castillo CF, Liss AS, Ting DT, Jacks T, Regev A. Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment. Nat Genet. 2022 08; 54(8):1178-1191. PMID: 35902743.
    Citations:    Fields:    
  4. Guo JA, Alshalalfa M, Kim DY, Hoffman HI, Shiau C, Su J, Hwang WL, Mahal BA. DNA repair and immune checkpoint blockade response. Cancer Genet. 2022 06; 264-265:1-4. PMID: 35245846.
    Citations:    Fields:    Translation:HumansCells
  5. Shi DD, Guo JA, Hoffman HI, Su J, Mino-Kenudson M, Barth JL, Schenkel JM, Loeffler JS, Shih HA, Hong TS, Wo JY, Aguirre AJ, Jacks T, Zheng L, Wen PY, Wang TC, Hwang WL. Therapeutic avenues for cancer neuroscience: translational frontiers and clinical opportunities. Lancet Oncol. 2022 02; 23(2):e62-e74. PMID: 35114133; PMCID: PMC9516432.
    Citations: 1     Fields:    Translation:Humans
  6. Burger ML, Cruz AM, Crossland GE, Gaglia G, Ritch CC, Blatt SE, Bhutkar A, Canner D, Kienka T, Tavana SZ, Barandiaran AL, Garmilla A, Schenkel JM, Hillman M, de Los Rios Kobara I, Li A, Jaeger AM, Hwang WL, Westcott PMK, Manos MP, Holovatska MM, Hodi FS, Regev A, Santagata S, Jacks T. Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors. Cell. 2021 09 16; 184(19):4996-5014.e26. PMID: 34534464; PMCID: PMC8522630.
    Citations: 9     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  7. Schenkel JM, Herbst RH, Canner D, Li A, Hillman M, Shanahan SL, Gibbons G, Smith OC, Kim JY, Westcott P, Hwang WL, Freed-Pastor WA, Eng G, Cuoco MS, Rogers P, Park JK, Burger ML, Rozenblatt-Rosen O, Cong L, Pauken KE, Regev A, Jacks T. Conventional type I dendritic cells maintain a reservoir of proliferative tumor-antigen specific TCF-1+ CD8+ T cells in tumor-draining lymph nodes. Immunity. 2021 10 12; 54(10):2338-2353.e6. PMID: 34534439; PMCID: PMC8604155.
    Citations: 16     Fields:    Translation:AnimalsCells
  8. Swami N, Hwang WL, Guo JA, Hoffman H, Abramowitz MC, Elbakouny Z, Beltran H, Chipidza F, Choueiri T, Pra AD, Huang F, Kaochar S, Kantoff P, Kim DW, Kishan AU, Kobetz E, Marinac C, Mucci LA, Muralidhar V, Pollack A, Sanford NN, Schaeffer EM, Spratt DE, Zhao SG, Rebbeck TR, Nguyen PL, Feng FY, Mahal BA, Alshalalfa M. Novel genomic signature predictive of response to immune checkpoint blockade: A pan-cancer analysis from project Genomics Evidence Neo-plasia Information Exchange (GENIE). Cancer Genet. 2021 11; 258-259:61-68. PMID: 34551377.
    Citations: 1     Fields:    Translation:Humans
  9. Freed-Pastor WA, Lambert LJ, Ely ZA, Pattada NB, Bhutkar A, Eng G, Mercer KL, Garcia AP, Lin L, Rideout WM, Hwang WL, Schenkel JM, Jaeger AM, Bronson RT, Westcott PMK, Hether TD, Divakar P, Reeves JW, Deshpande V, Delorey T, Phillips D, Yilmaz OH, Regev A, Jacks T. The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer. Cancer Cell. 2021 10 11; 39(10):1342-1360.e14. PMID: 34358448; PMCID: PMC8511341.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  10. Guo JA, Hoffman HI, Weekes CD, Zheng L, Ting DT, Hwang WL. Refining the Molecular Framework for Pancreatic Cancer with Single-cell and Spatial Technologies. Clin Cancer Res. 2021 07 15; 27(14):3825-3833. PMID: 33653818; PMCID: PMC8282742.
    Citations: 1     Fields:    Translation:HumansCells
  11. Guo JA, Hoffman HI, Shroff SG, Chen P, Hwang PG, Kim DY, Kim DW, Cheng SW, Zhao D, Mahal BA, Alshalalfa M, Niemierko A, Wo JY, Loeffler JS, Fernandez-Del Castillo C, Jacks T, Aguirre AJ, Hong TS, Mino-Kenudson M, Hwang WL. Pan-cancer Transcriptomic Predictors of Perineural Invasion Improve Occult Histopathologic Detection. Clin Cancer Res. 2021 05 15; 27(10):2807-2815. PMID: 33632928; PMCID: PMC8127360.
    Citations: 2     Fields:    Translation:HumansCells
  12. Grossberg AJ, Chu LC, Deig CR, Fishman EK, Hwang WL, Maitra A, Marks DL, Mehta A, Nabavizadeh N, Simeone DM, Weekes CD, Thomas CR. Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma. CA Cancer J Clin. 2020 09; 70(5):375-403. PMID: 32683683.
    Citations: 63     Fields:    Translation:Humans
  13. Hoffman HI, Guo JA, Hawkins MA, Bridgewater JA, Wo JY, Hong TS, Hwang WL. Silver Linings: An Opportunity to Improve Clinical Paradigms After the COVID-19 Pandemic. JCO Oncol Pract. 2020 09; 16(9):532-534. PMID: 32469687.
    Citations:    Fields:    Translation:HumansCellsPHPublic Health
  14. Mehta A, Hwang WL, Weekes C. The present and future of systemic and microenvironment-targeted therapy for pancreatic adenocarcinoma. Ann Pancreat Cancer. 2020 May; 3. PMID: 33294843.
  15. Lebow ES, Hwang WL, Zieminski S, Wang Y, Niemierko A, Mehan WA, Oh KS, Khandekar M, Willers H, Shih HA. Early experience with hippocampal avoidance whole brain radiation therapy and simultaneous integrated boost for brain metastases. J Neurooncol. 2020 May; 148(1):81-88. PMID: 32307637.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  16. Kim DW, Buzurovic IM, Mahal BV, Hwang W, Oladeru OT, O'Farrell DA, Harris TC, Margalit DN, Lam M, Devlin PM. Combined interstitial and surface high-dose-rate brachytherapy treatment of squamous cell carcinoma of the hand. J Contemp Brachytherapy. 2020 Feb; 12(1):48-52. PMID: 32190070; PMCID: PMC7073341.
    Citations: 1     
  17. Pike LRG, Royce TJ, Mahal AR, Kim DW, Hwang WL, Mahal BA, Sanford NN. Outcomes of HPV-Associated Squamous Cell Carcinoma of the Head and Neck: Impact of Race and Socioeconomic Status. J Natl Compr Canc Netw. 2020 02; 18(2):177-184. PMID: 32023531; PMCID: PMC7384230.
    Citations: 7     Fields:    Translation:Humans
  18. Lamba N, Hwang WL, Kim DW, Niemierko A, Marciscano AE, Mehan WA, Benayoun MD, Curry WT, Barker FG, Martuza RL, Dunn IF, Claus E, Bi WL, Aizer AA, Alexander BM, Oh KS, Loeffler JS, Shih HA. Atypical Histopathological Features and the Risk of Treatment Failure in Nonmalignant Meningiomas: A Multi-Institutional Analysis. World Neurosurg. 2020 Jan; 133:e804-e812. PMID: 31605839.
    Citations: 1     Fields:    Translation:Humans
  19. Niyazi M, Niemierko A, Paganetti H, Söhn M, Schapira E, Goldberg S, Adams J, Kim V, Oh KS, Hwang WL, Lu HM, Belka C, Busse PM, Loeffler JS, Shih HA. Volumetric and actuarial analysis of brain necrosis in proton therapy using a novel mixture cure model. Radiother Oncol. 2020 01; 142:154-161. PMID: 31563411.
    Citations: 10     Fields:    Translation:HumansPHPublic Health
  20. Sanford NN, Hwang WL, Pike LRG, Lam AC, Royce TJ, Mahal BA. Trimodality therapy for HPV-positive oropharyngeal cancer: A population-based study: Trimodality therapy for HPV+?OPC. Oral Oncol. 2019 11; 98:28-34. PMID: 31536843; PMCID: PMC7358785.
    Citations: 3     Fields:    Translation:HumansCellsPHPublic Health
  21. Hwang WL, Wolfson RL, Niemierko A, Marcus KJ, DuBois SG, Haas-Kogan D. Clinical Impact of Tumor Mutational Burden in Neuroblastoma. J Natl Cancer Inst. 2019 07 01; 111(7):695-699. PMID: 30307503.
    Citations: 13     Fields:    Translation:Humans
  22. Liu KX, Lamba N, Hwang WL, Niemierko A, DuBois SG, Haas-Kogan DA. Risk stratification by somatic mutation burden in Ewing sarcoma. Cancer. 2019 04 15; 125(8):1357-1364. PMID: 30602061.
    Citations: 7     Fields:    Translation:Humans
  23. Hwang WL, Niemierko A, Efstathiou JA. Comparing Adjuvant vs Early-Salvage Radiotherapy After Radical Prostatectomy-Reply. JAMA Oncol. 2018 11 01; 4(11):1620-1621. PMID: 30422248.
    Citations:    Fields:    Translation:Humans
  24. Pike LRG, Hwang WL, Royce TJ, Sanford NN, Mahal BA. HPV status predicts for improved survival following chemotherapy in metastatic squamous cell carcinoma of the oropharynx. Oral Oncol. 2018 11; 86:69-74. PMID: 30409322.
    Citations: 1     Fields:    Translation:HumansCells
  25. Sanford NN, Mahal BA, Royce TJ, Pike LRG, Hwang WL. Sex Disparity and Copy Number Alterations in Esophageal Squamous Cell Carcinoma. Clin Gastroenterol Hepatol. 2019 05; 17(6):1207-1209. PMID: 30120994.
    Citations: 1     Fields:    Translation:Humans
  26. Hwang WL, Pike LRG, Royce TJ, Mahal BA, Loeffler JS. Safety of combining radiotherapy with immune-checkpoint inhibition. Nat Rev Clin Oncol. 2018 08; 15(8):477-494. PMID: 29872177.
    Citations: 85     Fields:    Translation:Humans
  27. Hwang WL, Tendulkar RD, Niemierko A, Agrawal S, Stephans KL, Spratt DE, Hearn JW, Koontz BF, Lee WR, Michalski JM, Pisansky TM, Liauw SL, Abramowitz MC, Pollack A, Moghanaki D, Anscher MS, Den RB, Zietman AL, Stephenson AJ, Efstathiou JA. Comparison Between Adjuvant and Early-Salvage Postprostatectomy Radiotherapy for Prostate Cancer With Adverse Pathological Features. JAMA Oncol. 2018 05 10; 4(5):e175230. PMID: 29372236.
    Citations: 27     Fields:    Translation:Humans
  28. Hwang WL, Niemierko A, Hwang KL, Hubbeling H, Schapira E, Gainor JF, Keane FK. Clinical Outcomes in Patients With Metastatic Lung Cancer Treated With PD-1/PD-L1 Inhibitors and Thoracic Radiotherapy. JAMA Oncol. 2018 Feb 01; 4(2):253-255. PMID: 28973343.
    Citations: 31     Fields:    Translation:Humans
  29. Hwang WL, Pleskow HM, Miyamoto DT. Molecular analysis of circulating tumors cells: Biomarkers beyond enumeration. Adv Drug Deliv Rev. 2018 02 01; 125:122-131. PMID: 29326053.
    Citations: 8     Fields:    Translation:HumansCells
  30. Hwang KL, Hwang WL, Bussière MR, Shih HA. The role of radiotherapy in the management of high-grade meningiomas. Chin Clin Oncol. 2017 Jul; 6(Suppl 1):S5. PMID: 28758409.
    Citations: 6     Fields:    Translation:Humans
  31. Kim D, Niemierko A, Hwang WL, Stemmer-Rachamimov AO, Curry WT, Barker FG, Martuza RL, Oh KS, Loeffler JS, Shih HA. Histopathological prognostic factors of recurrence following definitive therapy for atypical and malignant meningiomas. J Neurosurg. 2018 04; 128(4):1123-1132. PMID: 28621619.
    Citations: 17     Fields:    Translation:Humans
  32. Zhou W, Sultana R, Diong C, Goh YT, Gopalakrishnan S, Ho A, Hwang W, Koh LP, Koh M, Loh Y, Tan P, Linn YC. Long-term renal outcome after allogeneic hemopoietic stem cell transplant: A comprehensive analysis of risk factors in an Asian patient population. Clin Transplant. 2017 04; 31(4). PMID: 28135776.
    Citations: 2     Fields:    Translation:Humans
  33. Hwang WL, Hwang KL, Miyamoto DT. The promise of circulating tumor cells for precision cancer therapy. Biomark Med. 2016 Dec; 10(12):1269-1285. PMID: 27924634.
    Citations: 6     Fields:    Translation:HumansCells
  34. Ghosh A, Tan TT, Linn YC, Gopalakrishnan S, Goh YT, Hwang W, Tan BH, Ho A, Phipps C. What We Learned From Plasma BK-Virus Monitoring in Allogeneic Hematopoietic Transplant Recipients. Transplantation. 2016 Apr; 100(4):e17-8. PMID: 26998851.
    Citations: 3     Fields:    Translation:HumansCells
  35. Harada BT, Hwang WL, Deindl S, Chatterjee N, Bartholomew B, Zhuang X. Stepwise nucleosome translocation by RSC remodeling complexes. Elife. 2016 Feb 19; 5. PMID: 26895087.
    Citations: 32     Fields:    Translation:AnimalsCells
  36. Tang T, Chen Z, Praditsuktavorn P, Khoo LP, Ruan J, Lim ST, Tan D, Phipps C, Lee YS, Goh YT, Hwang W, Tao M, Quek R, Farid M, Furman RR, Leonard JP, Martin P. Role of Surveillance Imaging in Patients With Peripheral T-Cell Lymphoma. Clin Lymphoma Myeloma Leuk. 2016 Mar; 16(3):117-21. PMID: 26796979.
    Citations: 3     Fields:    Translation:Humans
  37. Hwang WL, Marciscano AE, Niemierko A, Kim DW, Stemmer-Rachamimov AO, Curry WT, Barker FG, Martuza RL, Loeffler JS, Oh KS, Shih HA, Larvie M. Imaging and extent of surgical resection predict risk of meningioma recurrence better than WHO histopathological grade. Neuro Oncol. 2016 06; 18(6):863-72. PMID: 26597949; PMCID: PMC4864259.
    Citations: 33     Fields:    Translation:Humans
  38. Ma L, Hao S, Diong C, Goh YT, Gopalakrishnan S, Ho A, Hwang W, Koh LP, Koh M, Lim ZY, Loh Y, Poon M, Tan LK, Tan P, Linn YC. WPSS is a strong prognostic indicator for clinical outcome of allogeneic transplant for myelodysplastic syndrome in Southeast Asian patients. Ann Hematol. 2015 May; 94(5):761-9. PMID: 25519475.
    Citations: 2     Fields:    Translation:Humans
  39. Hwang WL, Deindl S, Harada BT, Zhuang X. Histone H4 tail mediates allosteric regulation of nucleosome remodelling by linker DNA. Nature. 2014 Aug 14; 512(7513):213-7. PMID: 25043036.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  40. Deindl S, Hwang WL, Hota SK, Blosser TR, Prasad P, Bartholomew B, Zhuang X. ISWI remodelers slide nucleosomes with coordinated multi-base-pair entry steps and single-base-pair exit steps. Cell. 2013 Jan 31; 152(3):442-52. PMID: 23374341.
    Citations: 75     Fields:    Translation:AnimalsCells
  41. Khoury M, Drake A, Chen Q, Dong D, Leskov I, Fragoso MF, Li Y, Iliopoulou BP, Hwang W, Lodish HF, Chen J. Mesenchymal stem cells secreting angiopoietin-like-5 support efficient expansion of human hematopoietic stem cells without compromising their repopulating potential. Stem Cells Dev. 2011 Aug; 20(8):1371-81. PMID: 21142526.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  42. Tan D, Teoh G, Lau LC, Lim A, Lim TH, Yap KC, Premalatha P, Lao ZT, Wee N, Choo C, Wee HC, Su S, Lee YS, Lee LH, Hwang W, Goh YT. An abnormal nonhyperdiploid karyotype is a significant adverse prognostic factor for multiple myeloma in the bortezomib era. Am J Hematol. 2010 Oct; 85(10):752-6. PMID: 20721886.
    Citations: 6     Fields:    Translation:Humans
  43. Maglia G, Heron AJ, Hwang WL, Holden MA, Mikhailova E, Li Q, Cheley S, Bayley H. Droplet networks with incorporated protein diodes show collective properties. Nat Nanotechnol. 2009 Jul; 4(7):437-40. PMID: 19581896.
    Citations: 57     Fields:    
  44. Syeda R, Holden MA, Hwang WL, Bayley H. Screening blockers against a potassium channel with a droplet interface bilayer array. J Am Chem Soc. 2008 Nov 19; 130(46):15543-8. PMID: 18950170.
    Citations: 38     Fields:    Translation:Cells
  45. Bayley H, Cronin B, Heron A, Holden MA, Hwang WL, Syeda R, Thompson J, Wallace M. Droplet interface bilayers. Mol Biosyst. 2008 Dec; 4(12):1191-208. PMID: 19396383.
    Citations: 124     Fields:    
  46. Hwang WL, Chen M, Cronin B, Holden MA, Bayley H. Asymmetric droplet interface bilayers. J Am Chem Soc. 2008 May 07; 130(18):5878-9. PMID: 18407631.
    Citations: 47     Fields:    
  47. Hwang WL, Holden MA, White S, Bayley H. Electrical behavior of droplet interface bilayer networks: experimental analysis and modeling. J Am Chem Soc. 2007 Sep 26; 129(38):11854-64. PMID: 17764183.
    Citations: 25     Fields:    
  48. Curry A, Hwang WL, Wax A. Epi-illumination through the microscope objective applied to darkfield imaging and microspectroscopy of nanoparticle interaction with cells in culture. Opt Express. 2006 Jul 10; 14(14):6535-42. PMID: 19516830.
    Citations: 8     Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.