Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Randall Theodore Peterson, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U54NS079201 (MACRAE, CALUM A.) Sep 30, 2012 - Aug 31, 2017
    A Discovery and Development Pipeline for Cyanide Countermeasures
    Role: Co-Principal Investigator
  2. R01GM088040 (JOUNG, J. KEITH) Aug 1, 2009 - Jul 31, 2017
    Role: Co-Principal Investigator
  3. R21MH085205 (PETERSON, RANDALL T) Jul 15, 2009 - Jun 30, 2011
    High-throughput behavioral screening for in vivo discovery of neuroactive drugs
    Role: Principal Investigator
  4. R01MH086867 (PETERSON, RANDALL T) Jul 2, 2009 - Apr 30, 2013
    In Vivo Discovery of Psychotropic Drugs by High-Throughput Behavioral Phenotyping
    Role: Principal Investigator
  5. R01DK082971 (BLOCH, DONALD B) Dec 1, 2008 - Jun 30, 2019
    Modulation of Hepcidin-Ferroportin Signaling using Small Molecules
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Tu J, Svatunek D, Parvez S, Liu AC, Levandowski BJ, Eckvahl HJ, Peterson RT, Houk KN, Franzini RM. Stable, Reactive, and Orthogonal Tetrazines: Dispersion Forces Promote the Cycloaddition with Isonitriles. Angew Chem Int Ed Engl. 2019 May 06. PMID: 31062496.
  2. Lam PY, Peterson RT. Developing zebrafish disease models for in vivo small molecule screens. Curr Opin Chem Biol. 2019 Mar 28; 50:37-44. PMID: 30928773.
  3. Peterson RT. 5-Nitrofurans and Cancer: Teaching an Old Drug New Tricks. Cell Chem Biol. 2018 Dec 20; 25(12):1439-1440. PMID: 30576659.
    Citations:    Fields:    
  4. Jordi J, Guggiana-Nilo D, Bolton AD, Prabha S, Ballotti K, Herrera K, Rennekamp AJ, Peterson RT, Lutz TA, Engert F. High-throughput screening for selective appetite modulators: A multibehavioral and translational drug discovery strategy. Sci Adv. 2018 10; 4(10):eaav1966. PMID: 30402545.
    Citations:    Fields:    
  5. Jin YN, Schlueter PJ, Jurisch-Yaksi N, Lam PY, Jin S, Hwang WY, Yeh JJ, Yoshigi M, Ong SE, Schenone M, Hartigan CR, Carr SA, Peterson RT. Noncanonical translation via deadenylated 3' UTRs maintains primordial germ cells. Nat Chem Biol. 2018 09; 14(9):844-852. PMID: 29988067.
    Citations:    Fields:    
  6. Basu S, Jalodia K, Ranjan S, Yeh JJ, Peterson RT, Sachidanandan C. Small Molecule Inhibitors of NFkB Reverse Iron Overload and Hepcidin Deregulation in a Zebrafish Model for Hereditary Hemochromatosis Type 3. ACS Chem Biol. 2018 08 17; 13(8):2143-2152. PMID: 29897731.
    Citations:    Fields:    
  7. Tu J, Xu M, Parvez S, Peterson RT, Franzini RM. Bioorthogonal Removal of 3-Isocyanopropyl Groups Enables the Controlled Release of Fluorophores and Drugs in Vivo. J Am Chem Soc. 2018 07 11; 140(27):8410-8414. PMID: 29927585.
    Citations:    Fields:    
  8. Sips PY, Shi X, Musso G, Nath AK, Zhao Y, Nielson J, Morningstar J, Kelly AE, Mikell B, Buys E, Bebarta V, Rutter J, Davisson VJ, Mahon S, Brenner M, Boss GR, Peterson RT, Gerszten RE, MacRae CA. Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning. PLoS One. 2018; 13(6):e0193889. PMID: 29879736.
    Citations:    Fields:    Translation:Animals
  9. Asnani A, Zheng B, Liu Y, Wang Y, Chen HH, Vohra A, Chi A, Cornella-Taracido I, Wang H, Johns DG, Sosnovik DE, Peterson RT. Highly potent visnagin derivatives inhibit Cyp1 and prevent doxorubicin cardiotoxicity. JCI Insight. 2018 Jan 11; 3(1). PMID: 29321375.
    Citations:    Fields:    
  10. O'Sullivan JF, Morningstar JE, Yang Q, Zheng B, Gao Y, Jeanfavre S, Scott J, Fernandez C, Zheng H, O'Connor S, Cohen P, Vasan RS, Long MT, Wilson JG, Melander O, Wang TJ, Fox C, Peterson RT, Clish CB, Corey KE, Gerszten RE. Dimethylguanidino valeric acid is a marker of liver fat and predicts diabetes. J Clin Invest. 2017 12 01; 127(12):4394-4402. PMID: 29083323.
    Citations: 4     Fields:    
  11. Lam PY, Mendu SK, Mills RW, Zheng B, Padilla H, Milan DJ, Desai BN, Peterson RT. A high-conductance chemo-optogenetic system based on the vertebrate channel Trpa1b. Sci Rep. 2017 09 19; 7(1):11839. PMID: 28928472.
    Citations:    Fields:    
  12. Bossé GD, Peterson RT. Development of an opioid self-administration assay to study drug seeking in zebrafish. Behav Brain Res. 2017 09 29; 335:158-166. PMID: 28811180.
    Citations: 1     Fields:    Translation:Animals
  13. Wu G, Nielson JR, Peterson RT, Winter JM. Bonnevillamides, Linear Heptapeptides Isolated from a Great Salt Lake-Derived Streptomyces sp. Mar Drugs. 2017 Jun 24; 15(7). PMID: 28672784.
    Citations:    Fields:    Translation:AnimalsCells
  14. Kimberly WT, O'Sullivan JF, Nath AK, Keyes M, Shi X, Larson MG, Yang Q, Long MT, Vasan R, Peterson RT, Wang TJ, Corey KE, Gerszten RE. Metabolite profiling identifies anandamide as a biomarker of nonalcoholic steatohepatitis. JCI Insight. 2017 May 04; 2(9). PMID: 28469090.
    Citations: 2     Fields:    
  15. Nath AK, Shi X, Harrison DL, Morningstar JE, Mahon S, Chan A, Sips P, Lee J, MacRae CA, Boss GR, Brenner M, Gerszten RE, Peterson RT. Cisplatin Analogs Confer Protection against Cyanide Poisoning. Cell Chem Biol. 2017 May 18; 24(5):565-575.e4. PMID: 28416275.
    Citations:    Fields:    Translation:HumansAnimalsCells
  16. Noonan HR, Metelo AM, Kamei CN, Peterson RT, Drummond IA, Iliopoulos O. Loss of vhl in the zebrafish pronephros recapitulates early stages of human clear cell renal cell carcinoma. Dis Model Mech. 2016 08 01; 9(8):873-84. PMID: 27491085.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  17. MacRae CA, Boss G, Brenner M, Gerszten RE, Mahon S, Peterson RT. A countermeasure development pipeline. Ann N Y Acad Sci. 2016 08; 1378(1):58-67. PMID: 27737495.
    Citations:    Fields:    Translation:HumansAnimals
  18. Rennekamp AJ, Huang XP, Wang Y, Patel S, Lorello PJ, Cade L, Gonzales AP, Yeh JR, Caldarone BJ, Roth BL, Kokel D, Peterson RT. s1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol. 2016 07; 12(7):552-8. PMID: 27239788.
    Citations: 4     Fields:    Translation:AnimalsCells
  19. Bruni G, Rennekamp AJ, Velenich A, McCarroll M, Gendelev L, Fertsch E, Taylor J, Lakhani P, Lensen D, Evron T, Lorello PJ, Huang XP, Kolczewski S, Carey G, Caldarone BJ, Prinssen E, Roth BL, Keiser MJ, Peterson RT, Kokel D. Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds. Nat Chem Biol. 2016 07; 12(7):559-66. PMID: 27239787.
    Citations: 11     Fields:    Translation:AnimalsCells
  20. Brady CA, Rennekamp AJ, Peterson RT. Chemical Screening in Zebrafish. Methods Mol Biol. 2016; 1451:3-16. PMID: 27464797.
    Citations: 4     Fields:    Translation:Animals
  21. Li X, Rhee DK, Malhotra R, Mayeur C, Hurst LA, Ager E, Shelton G, Kramer Y, McCulloh D, Keefe D, Bloch KD, Bloch DB, Peterson RT. Progesterone receptor membrane component-1 regulates hepcidin biosynthesis. J Clin Invest. 2016 Jan; 126(1):389-401. PMID: 26657863.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  22. Palchaudhuri R, Lambrecht MJ, Botham RC, Partlow KC, van Ham TJ, Putt KS, Nguyen LT, Kim SH, Peterson RT, Fan TM, Hergenrother PJ. A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed. Cell Rep. 2015 Dec 01; 13(9):2027-36. PMID: 26655912.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  23. MacRae CA, Peterson RT. Zebrafish as tools for drug discovery. Nat Rev Drug Discov. 2015 Oct; 14(10):721-31. PMID: 26361349.
    Citations: 90     Fields:    Translation:HumansAnimals
  24. Kleinstiver BP, Prew MS, Tsai SQ, Topkar VV, Nguyen NT, Zheng Z, Gonzales AP, Li Z, Peterson RT, Yeh JR, Aryee MJ, Joung JK. Engineered CRISPR-Cas9 nucleases with altered PAM specificities. Nature. 2015 Jul 23; 523(7561):481-5. PMID: 26098369.
    Citations: 256     Fields:    Translation:HumansAnimalsCells
  25. Vardy E, Sassano MF, Rennekamp AJ, Kroeze WK, Mosier PD, Westkaemper RB, Stevens CW, Katritch V, Stevens RC, Peterson RT, Roth BL. Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides. Chem Biol. 2015 Jun 18; 22(6):764-75. PMID: 26091169.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  26. Metelo AM, Noonan HR, Li X, Jin Y, Baker R, Kamentsky L, Zhang Y, van Rooijen E, Shin J, Carpenter AE, Yeh JR, Peterson RT, Iliopoulos O. Pharmacological HIF2a inhibition improves VHL disease-associated phenotypes in zebrafish model. J Clin Invest. 2015 May; 125(5):1987-97. PMID: 25866969.
    Citations: 8     Fields:    Translation:HumansAnimals
  27. Nath AK, Ryu JH, Jin YN, Roberts LD, Dejam A, Gerszten RE, Peterson RT. PTPMT1 Inhibition Lowers Glucose through Succinate Dehydrogenase Phosphorylation. Cell Rep. 2015 Feb 10; 10(5):694-701. PMID: 25660020.
    Citations: 7     Fields:    
  28. Liu Y, Asnani A, Zou L, Bentley VL, Yu M, Wang Y, Dellaire G, Sarkar KS, Dai M, Chen HH, Sosnovik DE, Shin JT, Haber DA, Berman JN, Chao W, Peterson RT. Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase. Sci Transl Med. 2014 Dec 10; 6(266):266ra170. PMID: 25504881.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  29. Rennekamp AJ, Peterson RT. 15 years of zebrafish chemical screening. Curr Opin Chem Biol. 2015 Feb; 24:58-70. PMID: 25461724.
    Citations: 47     Fields:    Translation:Animals
  30. Asnani A, Peterson RT. The zebrafish as a tool to identify novel therapies for human cardiovascular disease. Dis Model Mech. 2014 Jul; 7(7):763-7. PMID: 24973746.
    Citations: 26     Fields:    Translation:HumansAnimals
  31. van Ham TJ, Brady CA, Kalicharan RD, Oosterhof N, Kuipers J, Veenstra-Algra A, Sjollema KA, Peterson RT, Kampinga HH, Giepmans BN. Intravital correlated microscopy reveals differential macrophage and microglial dynamics during resolution of neuroinflammation. Dis Model Mech. 2014 Jul; 7(7):857-69. PMID: 24973753.
    Citations: 13     Fields:    Translation:AnimalsCells
  32. Hwang WY, Peterson RT, Yeh JR. Methods for targeted mutagenesis in zebrafish using TALENs. Methods. 2014 Aug 15; 69(1):76-84. PMID: 24747922.
    Citations: 6     Fields:    Translation:Animals
  33. Walcott BP, Peterson RT. Zebrafish models of cerebrovascular disease. J Cereb Blood Flow Metab. 2014 Apr; 34(4):571-7. PMID: 24517974.
    Citations: 7     Fields:    Translation:Animals
  34. Mayeur C, Lohmeyer LK, Leyton P, Kao SM, Pappas AE, Kolodziej SA, Spagnolli E, Yu B, Galdos RL, Yu PB, Peterson RT, Bloch DB, Bloch KD, Steinbicker AU. The type I BMP receptor Alk3 is required for the induction of hepatic hepcidin gene expression by interleukin-6. Blood. 2014 Apr 03; 123(14):2261-8. PMID: 24501215.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  35. Burger A, Vasilyev A, Tomar R, Selig MK, Nielsen GP, Peterson RT, Drummond IA, Haber DA. A zebrafish model of chordoma initiated by notochord-driven expression of HRASV12. Dis Model Mech. 2014 Jul; 7(7):907-13. PMID: 24311731.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  36. Ryu JH, Walcott BP, Kahle KT, Sheth SA, Peterson RT, Nahed BV, Coumans JV, Simard JM. Induced and sustained hypernatremia for the prevention and treatment of cerebral edema following brain injury. Neurocrit Care. 2013 Oct; 19(2):222-31. PMID: 23468135.
    Citations: 5     Fields:    Translation:Humans
  37. Goel S, Gupta N, Walcott BP, Snuderl M, Kesler CT, Kirkpatrick ND, Heishi T, Huang Y, Martin JD, Ager E, Samuel R, Wang S, Yazbek J, Vakoc BJ, Peterson RT, Padera TP, Duda DG, Fukumura D, Jain RK. Effects of vascular-endothelial protein tyrosine phosphatase inhibition on breast cancer vasculature and metastatic progression. J Natl Cancer Inst. 2013 Aug 21; 105(16):1188-201. PMID: 23899555.
    Citations: 31     Fields:    Translation:AnimalsCells
  38. Hwang WY, Fu Y, Reyon D, Maeder ML, Kaini P, Sander JD, Joung JK, Peterson RT, Yeh JR. Heritable and precise zebrafish genome editing using a CRISPR-Cas system. PLoS One. 2013; 8(7):e68708. PMID: 23874735.
    Citations: 116     Fields:    Translation:AnimalsCells
  39. Peng J, Li Q, Wigglesworth K, Rangarajan A, Kattamuri C, Peterson RT, Eppig JJ, Thompson TB, Matzuk MM. Reply to Mottershead et al.: GDF9:BMP15 heterodimers are potent regulators of ovarian functions. Proc Natl Acad Sci U S A. 2013 Jun 18; 110(25):E2258. PMID: 23940843.
    Citations: 1     Fields:    Translation:HumansAnimals
  40. Zhang Y, Wang J, Wheat J, Chen X, Jin S, Sadrzadeh H, Fathi AT, Peterson RT, Kung AL, Sweetser DA, Yeh JR. AML1-ETO mediates hematopoietic self-renewal and leukemogenesis through a COX/ß-catenin signaling pathway. Blood. 2013 Jun 13; 121(24):4906-16. PMID: 23645839.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  41. Kokel D, Dunn TW, Ahrens MB, Alshut R, Cheung CY, Saint-Amant L, Bruni G, Mateus R, van Ham TJ, Shiraki T, Fukada Y, Kojima D, Yeh JR, Mikut R, von Lintig J, Engert F, Peterson RT. Identification of nonvisual photomotor response cells in the vertebrate hindbrain. J Neurosci. 2013 Feb 27; 33(9):3834-43. PMID: 23447595.
    Citations: 27     Fields:    Translation:AnimalsCells
  42. Kokel D, Cheung CY, Mills R, Coutinho-Budd J, Huang L, Setola V, Sprague J, Jin S, Jin YN, Huang XP, Bruni G, Woolf CJ, Roth BL, Hamblin MR, Zylka MJ, Milan DJ, Peterson RT. Photochemical activation of TRPA1 channels in neurons and animals. Nat Chem Biol. 2013 Apr; 9(4):257-63. PMID: 23396078.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  43. Peng J, Li Q, Wigglesworth K, Rangarajan A, Kattamuri C, Peterson RT, Eppig JJ, Thompson TB, Matzuk MM. Growth differentiation factor 9:bone morphogenetic protein 15 heterodimers are potent regulators of ovarian functions. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):E776-85. PMID: 23382188.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  44. Hwang WY, Fu Y, Reyon D, Maeder ML, Tsai SQ, Sander JD, Peterson RT, Yeh JR, Joung JK. Efficient genome editing in zebrafish using a CRISPR-Cas system. Nat Biotechnol. 2013 Mar; 31(3):227-9. PMID: 23360964.
    Citations: 746     Fields:    Translation:AnimalsCells
  45. Nath AK, Roberts LD, Liu Y, Mahon SB, Kim S, Ryu JH, Werdich A, Januzzi JL, Boss GR, Rockwood GA, MacRae CA, Brenner M, Gerszten RE, Peterson RT. Chemical and metabolomic screens identify novel biomarkers and antidotes for cyanide exposure. FASEB J. 2013 May; 27(5):1928-38. PMID: 23345455.
    Citations: 13     Fields:    Translation:HumansAnimals
  46. Rennekamp AJ, Peterson RT. From phenotype to mechanism after zebrafish small molecule screens. Drug Discov Today Dis Models. 2013; 10(1):e51-e55. PMID: 26146505.
    Citations: 2     
  47. Ishaq O, Negri J, Bray MA, Pacureanu A, Peterson RT, Wählby C. AUTOMATED QUANTIFICATION OF ZEBRAFISH TAIL DEFORMATION FOR HIGH-THROUGHPUT DRUG SCREENING. Proc IEEE Int Symp Biomed Imaging. 2013; 902-905. PMID: 24499782.
    Citations: 1     
  48. Peterson RT, Macrae CA. Changing the Scale and Efficiency of Chemical Warfare Countermeasure Discovery Using the Zebrafish. Drug Discov Today Dis Models. 2013; 10(1). PMID: 24273586.
  49. Jin S, Sarkar KS, Jin YN, Liu Y, Kokel D, Van Ham TJ, Roberts LD, Gerszten RE, Macrae CA, Peterson RT. An in vivo zebrafish screen identifies organophosphate antidotes with diverse mechanisms of action. J Biomol Screen. 2013 Jan; 18(1):108-15. PMID: 22960781.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  50. Peterson RT. New mechanisms of 5-nitrofuran toxicity. Chem Biol. 2012 Jul 27; 19(7):789-90. PMID: 22840765.
    Citations:    Fields:    
  51. Cade L, Reyon D, Hwang WY, Tsai SQ, Patel S, Khayter C, Joung JK, Sander JD, Peterson RT, Yeh JR. Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs. Nucleic Acids Res. 2012 Sep; 40(16):8001-10. PMID: 22684503.
    Citations: 93     Fields:    Translation:AnimalsCells
  52. Kokel D, Rennekamp AJ, Shah AH, Liebel U, Peterson RT. Behavioral barcoding in the cloud: embracing data-intensive digital phenotyping in neuropharmacology. Trends Biotechnol. 2012 Aug; 30(8):421-5. PMID: 22652049.
    Citations: 12     Fields:    Translation:Animals
  53. van Ham TJ, Kokel D, Peterson RT. Apoptotic cells are cleared by directional migration and elmo1- dependent macrophage engulfment. Curr Biol. 2012 May 08; 22(9):830-6. PMID: 22503503.
    Citations: 21     Fields:    Translation:HumansCells
  54. Becker JR, Robinson TY, Sachidanandan C, Kelly AE, Coy S, Peterson RT, MacRae CA. In vivo natriuretic peptide reporter assay identifies chemical modifiers of hypertrophic cardiomyopathy signalling. Cardiovasc Res. 2012 Mar 01; 93(3):463-70. PMID: 22198505.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  55. Laggner C, Kokel D, Setola V, Tolia A, Lin H, Irwin JJ, Keiser MJ, Cheung CY, Minor DL, Roth BL, Peterson RT, Shoichet BK. Chemical informatics and target identification in a zebrafish phenotypic screen. Nat Chem Biol. 2011 Dec 18; 8(2):144-6. PMID: 22179068.
    Citations: 34     Fields:    Translation:Animals
  56. Peterson RT, Macrae CA. Systematic approaches to toxicology in the zebrafish. Annu Rev Pharmacol Toxicol. 2012; 52:433-53. PMID: 22017682.
    Citations: 40     Fields:    Translation:AnimalsCells
  57. Steinbicker AU, Bartnikas TB, Lohmeyer LK, Leyton P, Mayeur C, Kao SM, Pappas AE, Peterson RT, Bloch DB, Yu PB, Fleming MD, Bloch KD. Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice. Blood. 2011 Oct 13; 118(15):4224-30. PMID: 21841161.
    Citations: 61     Fields:    Translation:AnimalsCells
  58. Sander JD, Cade L, Khayter C, Reyon D, Peterson RT, Joung JK, Yeh JR. Targeted gene disruption in somatic zebrafish cells using engineered TALENs. Nat Biotechnol. 2011 Aug 05; 29(8):697-8. PMID: 21822241.
    Citations: 208     Fields:    Translation:Humans
  59. Garkavtsev I, Chauhan VP, Wong HK, Mukhopadhyay A, Glicksman MA, Peterson RT, Jain RK. Dehydro-alpha-lapachone, a plant product with antivascular activity. Proc Natl Acad Sci U S A. 2011 Jul 12; 108(28):11596-601. PMID: 21709229.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  60. Steinbicker AU, Sachidanandan C, Vonner AJ, Yusuf RZ, Deng DY, Lai CS, Rauwerdink KM, Winn JC, Saez B, Cook CM, Szekely BA, Roy CN, Seehra JS, Cuny GD, Scadden DT, Peterson RT, Bloch KD, Yu PB. Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation. Blood. 2011 May 05; 117(18):4915-23. PMID: 21393479.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  61. Kokel D, Peterson RT. Using the zebrafish photomotor response for psychotropic drug screening. Methods Cell Biol. 2011; 105:517-24. PMID: 21951545.
    Citations: 18     Fields:    Translation:HumansAnimals
  62. Sander JD, Yeh JR, Peterson RT, Joung JK. Engineering zinc finger nucleases for targeted mutagenesis of zebrafish. Methods Cell Biol. 2011; 104:51-8. PMID: 21924156.
    Citations: 18     Fields:    Translation:AnimalsCells
  63. Peterson RT, Fishman MC. Designing zebrafish chemical screens. Methods Cell Biol. 2011; 105:525-41. PMID: 21951546.
    Citations: 24     Fields:    Translation:HumansAnimals
  64. Groeneweg JW, White YA, Kokel D, Peterson RT, Zukerberg LR, Berin I, Rueda BR, Wood AW. cables1 is required for embryonic neural development: molecular, cellular, and behavioral evidence from the zebrafish. Mol Reprod Dev. 2011 Jan; 78(1):22-32. PMID: 21268180.
    Citations: 1     Fields:    Translation:Animals
  65. Sander JD, Dahlborg EJ, Goodwin MJ, Cade L, Zhang F, Cifuentes D, Curtin SJ, Blackburn JS, Thibodeau-Beganny S, Qi Y, Pierick CJ, Hoffman E, Maeder ML, Khayter C, Reyon D, Dobbs D, Langenau DM, Stupar RM, Giraldez AJ, Voytas DF, Peterson RT, Yeh JR, Joung JK. Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA). Nat Methods. 2011 Jan; 8(1):67-9. PMID: 21151135.
    Citations: 175     Fields:    Translation:AnimalsCells
  66. Peal DS, Mills RW, Lynch SN, Mosley JM, Lim E, Ellinor PT, January CT, Peterson RT, Milan DJ. Novel chemical suppressors of long QT syndrome identified by an in vivo functional screen. Circulation. 2011 Jan 04; 123(1):23-30. PMID: 21098441.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  67. Peal DS, Peterson RT, Milan D. Small molecule screening in zebrafish. J Cardiovasc Transl Res. 2010 Oct; 3(5):454-60. PMID: 20680709.
    Citations: 20     Fields:    Translation:AnimalsCells
  68. van Ham TJ, Mapes J, Kokel D, Peterson RT. Live imaging of apoptotic cells in zebrafish. FASEB J. 2010 Nov; 24(11):4336-42. PMID: 20601526.
    Citations: 25     Fields:    Translation:Animals
  69. Kaul D, Wu CL, Adkins CB, Jordan KW, Defeo EM, Habbel P, Peterson RT, McDougal WS, Pohl U, Cheng LL. Assessing prostate cancer growth with mRNA of spermine metabolic enzymes. Cancer Biol Ther. 2010 May 01; 9(9):736-42. PMID: 20215859.
    Citations: 5     Fields:    Translation:Humans
  70. Das BC, McCartin K, Liu TC, Peterson RT, Evans T. A forward chemical screen in zebrafish identifies a retinoic acid derivative with receptor specificity. PLoS One. 2010 Apr 02; 5(4):e10004. PMID: 20368991.
    Citations: 12     Fields:    Translation:AnimalsCells
  71. Ren B, Deng Y, Mukhopadhyay A, Lanahan AA, Zhuang ZW, Moodie KL, Mulligan-Kehoe MJ, Byzova TV, Peterson RT, Simons M. ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish. J Clin Invest. 2010 Apr; 120(4):1217-28. PMID: 20237411.
    Citations: 51     Fields:    Translation:AnimalsCells
  72. Kokel D, Bryan J, Laggner C, White R, Cheung CY, Mateus R, Healey D, Kim S, Werdich AA, Haggarty SJ, Macrae CA, Shoichet B, Peterson RT. Rapid behavior-based identification of neuroactive small molecules in the zebrafish. Nat Chem Biol. 2010 Mar; 6(3):231-237. PMID: 20081854.
    Citations: 139     Fields:    
  73. Rihel J, Prober DA, Arvanites A, Lam K, Zimmerman S, Jang S, Haggarty SJ, Kokel D, Rubin LL, Peterson RT, Schier AF. Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation. Science. 2010 Jan 15; 327(5963):348-51. PMID: 20075256.
    Citations: 173     Fields:    Translation:AnimalsCells
  74. Peterson RT. Drug discovery: Propping up a destructive regime. Nature. 2009 Oct 01; 461(7264):599-600. PMID: 19794479.
    Citations:    Fields:    Translation:HumansCells
  75. Milan DJ, Kim AM, Winterfield JR, Jones IL, Pfeufer A, Sanna S, Arking DE, Amsterdam AH, Sabeh KM, Mably JD, Rosenbaum DS, Peterson RT, Chakravarti A, Kääb S, Roden DM, MacRae CA. Drug-sensitized zebrafish screen identifies multiple genes, including GINS3, as regulators of myocardial repolarization. Circulation. 2009 Aug 18; 120(7):553-9. PMID: 19652097.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  76. Schlueter PJ, Peterson RT. Systematizing serendipity for cardiovascular drug discovery. Circulation. 2009 Jul 21; 120(3):255-63. PMID: 19620524.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  77. Kitambi SS, McCulloch KJ, Peterson RT, Malicki JJ. Small molecule screen for compounds that affect vascular development in the zebrafish retina. Mech Dev. 2009 May-Jun; 126(5-6):464-77. PMID: 19445054.
    Citations: 37     Fields:    Translation:Animals
  78. Foley JE, Yeh JR, Maeder ML, Reyon D, Sander JD, Peterson RT, Joung JK. Rapid mutation of endogenous zebrafish genes using zinc finger nucleases made by Oligomerized Pool ENgineering (OPEN). PLoS One. 2009; 4(2):e4348. PMID: 19198653.
    Citations: 99     Fields:    Translation:AnimalsCells
  79. Yeh JR, Peterson RT. Novel Wnt antagonists target porcupine and Axin. Nat Chem Biol. 2009 Feb; 5(2):74-5. PMID: 19148172.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  80. Yeh JR, Munson KM, Elagib KE, Goldfarb AN, Sweetser DA, Peterson RT. Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation. Nat Chem Biol. 2009 Apr; 5(4):236-43. PMID: 19172146.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  81. Foley JE, Maeder ML, Pearlberg J, Joung JK, Peterson RT, Yeh JR. Targeted mutagenesis in zebrafish using customized zinc-finger nucleases. Nat Protoc. 2009; 4(12):1855-67. PMID: 20010934.
    Citations: 39     Fields:    Translation:AnimalsCells
  82. Yu PB, Deng DY, Lai CS, Hong CC, Cuny GD, Bouxsein ML, Hong DW, McManus PM, Katagiri T, Sachidanandan C, Kamiya N, Fukuda T, Mishina Y, Peterson RT, Bloch KD. BMP type I receptor inhibition reduces heterotopic [corrected] ossification. Nat Med. 2008 Dec; 14(12):1363-9. PMID: 19029982.
    Citations: 223     Fields:    Translation:AnimalsCells
  83. Peterson RT. Chemical biology and the limits of reductionism. Nat Chem Biol. 2008 Nov; 4(11):635-8. PMID: 18936741.
    Citations: 14     Fields:    
  84. Hong CC, Kume T, Peterson RT. Role of crosstalk between phosphatidylinositol 3-kinase and extracellular signal-regulated kinase/mitogen-activated protein kinase pathways in artery-vein specification. Circ Res. 2008 Sep 12; 103(6):573-9. PMID: 18796644.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  85. Kokel D, Peterson RT. Chemobehavioural phenomics and behaviour-based psychiatric drug discovery in the zebrafish. Brief Funct Genomic Proteomic. 2008 Nov; 7(6):483-90. PMID: 18784194.
    Citations: 20     Fields:    Translation:Animals
  86. Hao J, Daleo MA, Murphy CK, Yu PB, Ho JN, Hu J, Peterson RT, Hatzopoulos AK, Hong CC. Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells. PLoS One. 2008 Aug 06; 3(8):e2904. PMID: 18682835.
    Citations: 79     Fields:    Translation:HumansCells
  87. Cuny GD, Yu PB, Laha JK, Xing X, Liu JF, Lai CS, Deng DY, Sachidanandan C, Bloch KD, Peterson RT. Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorg Med Chem Lett. 2008 Aug 01; 18(15):4388-92. PMID: 18621530.
    Citations: 115     Fields:    Translation:AnimalsCells
  88. Mukhopadhyay A, Peterson RT. Deciphering arterial identity through gene expression, genetics, and chemical biology. Curr Opin Hematol. 2008 May; 15(3):221-7. PMID: 18391789.
    Citations: 1     Fields:    Translation:HumansAnimals
  89. Peterson RT, Nass R, Boyd WA, Freedman JH, Dong K, Narahashi T. Use of non-mammalian alternative models for neurotoxicological study. Neurotoxicology. 2008 May; 29(3):546-55. PMID: 18538410.
    Citations: 28     Fields:    Translation:Animals
  90. Sachidanandan C, Yeh JR, Peterson QP, Peterson RT. Identification of a novel retinoid by small molecule screening with zebrafish embryos. PLoS One. 2008 Apr 09; 3(4):e1947. PMID: 18398471.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  91. Dayyani F, Wang J, Yeh JR, Ahn EY, Tobey E, Zhang DE, Bernstein ID, Peterson RT, Sweetser DA. Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival. Blood. 2008 Apr 15; 111(8):4338-47. PMID: 18258796.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  92. Yeh JR, Munson KM, Chao YL, Peterson QP, Macrae CA, Peterson RT. AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression. Development. 2008 Jan; 135(2):401-10. PMID: 18156164.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  93. Yu PB, Hong CC, Sachidanandan C, Babitt JL, Deng DY, Hoyng SA, Lin HY, Bloch KD, Peterson RT. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol. 2008 Jan; 4(1):33-41. PMID: 18026094.
    Citations: 358     Fields:    Translation:AnimalsCells
  94. Mathew LK, Sengupta S, Kawakami A, Andreasen EA, Löhr CV, Loynes CA, Renshaw SA, Peterson RT, Tanguay RL. Unraveling tissue regeneration pathways using chemical genetics. J Biol Chem. 2007 Nov 30; 282(48):35202-10. PMID: 17848559.
    Citations: 44     Fields:    Translation:AnimalsCells
  95. Smolen GA, Schott BJ, Stewart RA, Diederichs S, Muir B, Provencher HL, Look AT, Sgroi DC, Peterson RT, Haber DA. A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors. Genes Dev. 2007 Sep 01; 21(17):2131-6. PMID: 17704304.
    Citations: 16     Fields:    Translation:Animals
  96. Peterson RT. A noncanonical path to mechanism of action. Chem Biol. 2006 Sep; 13(9):924-6. PMID: 16984880.
    Citations: 1     Fields:    Translation:AnimalsCells
  97. Hong CC, Peterson QP, Hong JY, Peterson RT. Artery/vein specification is governed by opposing phosphatidylinositol-3 kinase and MAP kinase/ERK signaling. Curr Biol. 2006 Jul 11; 16(13):1366-72. PMID: 16824925.
    Citations: 63     Fields:    Translation:AnimalsCells
  98. Mukhopadhyay A, Peterson RT. Fishing for new antimicrobials. Curr Opin Chem Biol. 2006 Aug; 10(4):327-33. PMID: 16822704.
    Citations: 2     Fields:    Translation:Animals
  99. Milan DJ, Giokas AC, Serluca FC, Peterson RT, MacRae CA. Notch1b and neuregulin are required for specification of central cardiac conduction tissue. Development. 2006 Mar; 133(6):1125-32. PMID: 16481353.
    Citations: 61     Fields:    Translation:AnimalsCells
  100. Zon LI, Peterson RT. In vivo drug discovery in the zebrafish. Nat Rev Drug Discov. 2005 Jan; 4(1):35-44. PMID: 15688071.
    Citations: 293     Fields:    Translation:HumansAnimals
  101. Peterson RT. Discovery of therapeutic targets by phenotype-based zebrafish screens. Drug Discov Today Technol. 2004 Sep; 1(1):49-54. PMID: 24981267.
    Citations:    Fields:    
  102. Del Monte F, Dalal R, Tabchy A, Couget J, Bloch KD, Peterson R, Hajjar RJ. Transcriptional changes following restoration of SERCA2a levels in failing rat hearts. FASEB J. 2004 Sep; 18(12):1474-6. PMID: 15247151.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  103. Shafizadeh E, Peterson RT, Lin S. Induction of reversible hemolytic anemia in living zebrafish using a novel small molecule. Comp Biochem Physiol C Toxicol Pharmacol. 2004 Jul; 138(3):245-9. PMID: 15533782.
    Citations: 9     Fields:    Translation:AnimalsCells
  104. Peterson RT, Shaw SY, Peterson TA, Milan DJ, Zhong TP, Schreiber SL, MacRae CA, Fishman MC. Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation. Nat Biotechnol. 2004 May; 22(5):595-9. PMID: 15097998.
    Citations: 114     Fields:    Translation:AnimalsCells
  105. Peterson RT, Fishman MC. Discovery and use of small molecules for probing biological processes in zebrafish. Methods Cell Biol. 2004; 76:569-91. PMID: 15602893.
    Citations: 24     Fields:    Translation:Animals
  106. MacRae CA, Peterson RT. Zebrafish-based small molecule discovery. Chem Biol. 2003 Oct; 10(10):901-8. PMID: 14583256.
    Citations: 40     Fields:    Translation:Animals
  107. Milan DJ, Peterson TA, Ruskin JN, Peterson RT, MacRae CA. Drugs that induce repolarization abnormalities cause bradycardia in zebrafish. Circulation. 2003 Mar 18; 107(10):1355-8. PMID: 12642353.
    Citations: 94     Fields:    Translation:Animals
  108. Peterson RT, Mably JD, Chen JN, Fishman MC. Convergence of distinct pathways to heart patterning revealed by the small molecule concentramide and the mutation heart-and-soul. Curr Biol. 2001 Oct 02; 11(19):1481-91. PMID: 11591315.
    Citations: 31     Fields:    Translation:AnimalsCells
  109. Peterson RT, Link BA, Dowling JE, Schreiber SL. Small molecule developmental screens reveal the logic and timing of vertebrate development. Proc Natl Acad Sci U S A. 2000 Nov 21; 97(24):12965-9. PMID: 11087852.
    Citations: 115     Fields:    Translation:AnimalsCells
  110. Peterson RT, Beal PA, Comb MJ, Schreiber SL. FKBP12-rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions. J Biol Chem. 2000 Mar 10; 275(10):7416-23. PMID: 10702316.
    Citations: 102     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  111. Peterson RT, Schreiber SL. Kinase phosphorylation: Keeping it all in the family. Curr Biol. 1999 Jul 15; 9(14):R521-4. PMID: 10421571.
    Citations: 27     Fields:    Translation:HumansCells
  112. Peterson RT, Desai BN, Hardwick JS, Schreiber SL. Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein. Proc Natl Acad Sci U S A. 1999 Apr 13; 96(8):4438-42. PMID: 10200280.
    Citations: 122     Fields:    Translation:HumansCells
  113. Chen J, Peterson RT, Schreiber SL. Alpha 4 associates with protein phosphatases 2A, 4, and 6. Biochem Biophys Res Commun. 1998 Jun 29; 247(3):827-32. PMID: 9647778.
    Citations: 50     Fields:    Translation:HumansCells
  114. Peterson RT, Schreiber SL. Translation control: connecting mitogens and the ribosome. Curr Biol. 1998 Mar 26; 8(7):R248-50. PMID: 9545190.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.