Harvard Catalyst Profiles

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Elizabeth Beryl Klerman, Ph.D., M.D.

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selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Rahman SA, Sullivan JP, Barger LK, St Hilaire MA, O'Brien CS, Stone KL, Phillips AJK, Klerman EB, Qadri S, Wright KP, Halbower AC, Segar JL, McGuire JK, Vitiello MV, de la Iglesia HO, Poynter SE, Yu PL, Sanderson AL, Zee PC, Landrigan CP, Czeisler CA, Lockley SW. Extended Work Shifts and Neurobehavioral Performance in Resident-Physicians. Pediatrics. 2021 Mar; 147(3). PMID: 33619044.
    Citations:    Fields:    
  2. Duffy JF, Abbott SM, Burgess HJ, Crowley SJ, Emens JS, Epstein LJ, Gamble KL, Hasler BP, Kristo DA, Malkani RG, Rahman SA, Thomas SJ, Wyatt JK, Zee PC, Klerman EB. Workshop report. Circadian rhythm sleep-wake disorders: gaps and opportunities. Sleep. 2021 Feb 14. PMID: 33582815.
    Citations:    Fields:    
  3. McHill AW, Sano A, Hilditch CJ, Barger LK, Czeisler CA, Picard R, Klerman EB. Robust stability of melatonin circadian phase, sleep metrics, and chronotype across months in young adults living in real-world settings. J Pineal Res. 2021 Feb 01; e12720. PMID: 33523499.
    Citations:    Fields:    
  4. McHill AW, Hilditch CJ, Fischer D, Czeisler CA, Garaulet M, Scheer FAJL, Klerman EB. Stability of the timing of food intake at daily and monthly timescales in young adults. Sci Rep. 2020 11 30; 10(1):20849. PMID: 33257712.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  5. Charmaraman L, Richer AM, Ben-Joseph EP, Klerman EB. Quantity, Content, and Context Matter: Associations Among Social Technology Use and Sleep Habits in Early Adolescents. J Adolesc Health. 2020 Nov 01. PMID: 33148478.
    Citations:    Fields:    
  6. Cochrane C, Ba D, Klerman EB, St Hilaire MA. An ensemble mixed effects model of sleep loss and performance. J Theor Biol. 2021 01 21; 509:110497. PMID: 32966825.
    Citations:    Fields:    
  7. Fischer D, McHill AW, Sano A, Picard RW, Barger LK, Czeisler CA, Klerman EB, Phillips AJK. Irregular sleep and event schedules are associated with poorer self-reported well-being in US college students. Sleep. 2020 06 15; 43(6). PMID: 31837266.
    Citations: 2     Fields:    
  8. Rijo-Ferreira F, Acosta-Rodriguez VA, Abel JH, Kornblum I, Bento I, Kilaru G, Klerman EB, Mota MM, Takahashi JS. The malaria parasite has an intrinsic clock. Science. 2020 05 15; 368(6492):746-753. PMID: 32409471.
    Citations: 8     Fields:    Translation:AnimalsCells
  9. Klerman EB, Rahman SA, St Hilaire MA. What time is it? A tale of three clocks, with implications for personalized medicine. J Pineal Res. 2020 05; 68(4):e12646. PMID: 32155668.
    Citations: 1     Fields:    
  10. Roenneberg T, Winnebeck EC, Klerman EB. Corrigendum: Daylight Saving Time and Artificial Time Zones - A Battle Between Biological and Social Times. Front Physiol. 2019; 10:1177. PMID: 31572222.
    Citations:    
  11. Chua EC, Sullivan JP, Duffy JF, Klerman EB, Lockley SW, Kristal BS, Czeisler CA, Gooley JJ. Classifying attentional vulnerability to total sleep deprivation using baseline features of Psychomotor Vigilance Test performance. Sci Rep. 2019 08 20; 9(1):12102. PMID: 31431644.
    Citations:    Fields:    Translation:Humans
  12. Roenneberg T, Winnebeck EC, Klerman EB. Daylight Saving Time and Artificial Time Zones - A Battle Between Biological and Social Times. Front Physiol. 2019; 10:944. PMID: 31447685.
    Citations: 8     
  13. Kronauer RE, St Hilaire MA, Rahman SA, Czeisler CA, Klerman EB. An Exploration of the Temporal Dynamics of Circadian Resetting Responses to Short- and Long-Duration Light Exposures: Cross-Species Consistencies and Differences. J Biol Rhythms. 2019 10; 34(5):497-514. PMID: 31368391.
    Citations: 2     Fields:    Translation:HumansAnimals
  14. Roenneberg T, Wirz-Justice A, Skene DJ, Ancoli-Israel S, Wright KP, Dijk DJ, Zee P, Gorman MR, Winnebeck EC, Klerman EB. Why Should We Abolish Daylight Saving Time? J Biol Rhythms. 2019 06; 34(3):227-230. PMID: 31170882.
    Citations: 9     Fields:    Translation:Humans
  15. Schwartz WJ, Klerman EB. Circadian Neurobiology and the Physiologic Regulation of Sleep and Wakefulness. Neurol Clin. 2019 08; 37(3):475-486. PMID: 31256784.
    Citations: 3     Fields:    Translation:HumansAnimals
  16. McHill AW, Hull JT, Cohen DA, Wang W, Czeisler CA, Klerman EB. Chronic sleep restriction greatly magnifies performance decrements immediately after awakening. Sleep. 2019 05 01; 42(5). PMID: 30722039.
    Citations: 4     Fields:    Translation:Humans
  17. Chang AM, Duffy JF, Buxton OM, Lane JM, Aeschbach D, Anderson C, Bjonnes AC, Cain SW, Cohen DA, Frayling TM, Gooley JJ, Jones SE, Klerman EB, Lockley SW, Munch M, Rajaratnam SMW, Rueger M, Rutter MK, Santhi N, Scheuermaier K, Van Reen E, Weedon MN, Czeisler CA, Scheer FAJL, Saxena R. Chronotype Genetic Variant in PER2 is Associated with Intrinsic Circadian Period in Humans. Sci Rep. 2019 03 29; 9(1):5350. PMID: 30926824.
    Citations: 4     Fields:    Translation:Humans
  18. McHill AW, Czeisler CA, Phillips AJK, Keating L, Barger LK, Garaulet M, Scheer FAJL, Klerman EB. Caloric and Macronutrient Intake Differ with Circadian Phase and between Lean and Overweight Young Adults. Nutrients. 2019 03 11; 11(3). PMID: 30862011.
    Citations: 7     Fields:    Translation:Humans
  19. Rahman SA, Bibbo C, Olcese J, Czeisler CA, Robinson JN, Klerman EB. Relationship between endogenous melatonin concentrations and uterine contractions in late third trimester of human pregnancy. J Pineal Res. 2019 May; 66(4):e12566. PMID: 30739346.
    Citations: 2     Fields:    Translation:Humans
  20. Gu F, Klerman EB, Kim S, Moore S, Yu K, Albert PS, Caporaso NE. Diurnal variation of metabolites in three individual participants. Chronobiol Int. 2019 03; 36(3):332-342. PMID: 30557062.
    Citations: 2     Fields:    Translation:Humans
  21. Abel JH, Chakrabarty A, Klerman EB, Doyle FJ. Pharmaceutical-based entrainment of circadian phase via nonlinear model predictive control. Automatica (Oxf). 2019 Feb; 100:336-348. PMID: 31673164.
    Citations: 2     
  22. Schneider J, Saenz-Otero A, Klerman E, Stirling L. Strategy Development Pilot Study of Sleep-Restricted Operators Using Small Satellites with Displays. Aerosp Med Hum Perform. 2018 12 01; 89(12):1036-1044. PMID: 30487023.
    Citations:    Fields:    Translation:Humans
  23. Weaver MD, Barger LK, Malone SK, Anderson LS, Klerman EB. Dose-Dependent Associations Between Sleep Duration and Unsafe Behaviors Among US High School Students. JAMA Pediatr. 2018 12 01; 172(12):1187-1189. PMID: 30285029.
    Citations: 5     Fields:    Translation:Humans
  24. Asgari-Targhi A, Klerman EB. Mathematical modeling of circadian rhythms. Wiley Interdiscip Rev Syst Biol Med. 2019 03; 11(2):e1439. PMID: 30328684.
    Citations: 4     Fields:    Translation:HumansAnimals
  25. Caporaso NE, Gu F, Klerman EB, Devesa SS, Jones RR, Zhang F, Cahoon EK, Graubard BI. Longitude Position in a Time Zone and Cancer Risk-Response. Cancer Epidemiol Biomarkers Prev. 2018 09; 27(9):1111-1112. PMID: 30181322.
    Citations:    Fields:    Translation:Humans
  26. McHill AW, Hull JT, McMullan CJ, Klerman EB. Chronic Insufficient Sleep Has a Limited Impact on Circadian Rhythmicity of Subjective Hunger and Awakening Fasted Metabolic Hormones. Front Endocrinol (Lausanne). 2018; 9:319. PMID: 29946297.
    Citations: 6     
  27. Sano A, Taylor S, McHill AW, Phillips AJ, Barger LK, Klerman E, Picard R. Identifying Objective Physiological Markers and Modifiable Behaviors for Self-Reported Stress and Mental Health Status Using Wearable Sensors and Mobile Phones: Observational Study. J Med Internet Res. 2018 06 08; 20(6):e210. PMID: 29884610.
    Citations: 22     Fields:    Translation:Humans
  28. McHill AW, Hull JT, Wang W, Czeisler CA, Klerman EB. Chronic sleep curtailment, even without extended (>16-h) wakefulness, degrades human vigilance performance. Proc Natl Acad Sci U S A. 2018 06 05; 115(23):6070-6075. PMID: 29784810.
    Citations: 11     Fields:    Translation:Humans
  29. Rahman SA, St Hilaire MA, Gronfier C, Chang AM, Santhi N, Czeisler CA, Klerman EB, Lockley SW. Functional decoupling of melatonin suppression and circadian phase resetting in humans. J Physiol. 2018 06; 596(11):2147-2157. PMID: 29707782.
    Citations: 13     Fields:    Translation:Humans
  30. Williams JS, Autori PJ, Kidd SK, Piazza G, Connors MC, Czeisler CA, Scheuermaier KD, Duffy J, Klerman EB, Scheer FA, Kozak M, Driscoll SM, Goldhaber SZ. Heparin-Induced Thrombocytopenia in Healthy Individuals with Continuous Heparin Infusion. TH Open. 2018 Jan; 2(1):e49-e53. PMID: 31249929.
    Citations:    
  31. Phillips AJK, Klerman EB, Butler JP. Modeling the adenosine system as a modulator of cognitive performance and sleep patterns during sleep restriction and recovery. PLoS Comput Biol. 2017 Oct; 13(10):e1005759. PMID: 29073206.
    Citations: 5     Fields:    Translation:Humans
  32. Videnovic A, Klerman EB, Zee PC. Light Therapy Promoting Dopamine Release by Stimulating Retina in Parkinson Disease-Reply. JAMA Neurol. 2017 10 01; 74(10):1268-1269. PMID: 28806434.
    Citations: 3     Fields:    Translation:Humans
  33. McHill AW, Phillips AJ, Czeisler CA, Keating L, Yee K, Barger LK, Garaulet M, Scheer FA, Klerman EB. Later circadian timing of food intake is associated with increased body fat. Am J Clin Nutr. 2017 Nov; 106(5):1213-1219. PMID: 28877894.
    Citations: 51     Fields:    Translation:Humans
  34. Phillips AJK, Clerx WM, O'Brien CS, Sano A, Barger LK, Picard RW, Lockley SW, Klerman EB, Czeisler CA. Irregular sleep/wake patterns are associated with poorer academic performance and delayed circadian and sleep/wake timing. Sci Rep. 2017 06 12; 7(1):3216. PMID: 28607474.
    Citations: 49     Fields:    Translation:Humans
  35. Gu F, Xu S, Devesa SS, Zhang F, Klerman EB, Graubard BI, Caporaso NE. Longitude Position in a Time Zone and Cancer Risk in the United States. Cancer Epidemiol Biomarkers Prev. 2017 08; 26(8):1306-1311. PMID: 28450580.
    Citations: 13     Fields:    Translation:Humans
  36. Chen W, Sano A, Martinez DL, Taylor S, McHill AW, Phillips AJK, Barger L, Klerman EB, Picard RW. Multimodal Ambulatory Sleep Detection. IEEE EMBS Int Conf Biomed Health Inform. 2017 Feb; 2017:465-468. PMID: 29938711.
    Citations: 2     
  37. Rahman SA, St Hilaire MA, Chang AM, Santhi N, Duffy JF, Kronauer RE, Czeisler CA, Lockley SW, Klerman EB. Circadian phase resetting by a single short-duration light exposure. JCI Insight. 2017 04 06; 2(7):e89494. PMID: 28405608.
    Citations: 9     Fields:    Translation:HumansCTClinical Trials
  38. Swaminathan K, Klerman EB, Phillips AJK. Are Individual Differences in Sleep and Circadian Timing Amplified by Use of Artificial Light Sources? J Biol Rhythms. 2017 04; 32(2):165-176. PMID: 28367676.
    Citations: 9     Fields:    Translation:Humans
  39. Videnovic A, Klerman EB, Wang W, Marconi A, Kuhta T, Zee PC. Timed Light Therapy for Sleep and Daytime Sleepiness Associated With Parkinson Disease: A Randomized Clinical Trial. JAMA Neurol. 2017 Apr 01; 74(4):411-418. PMID: 28241159.
    Citations: 35     Fields:    Translation:Humans
  40. Gupta M, Beckett SA, Klerman EB. On-line EEG Denoising and Cleaning Using Correlated Sparse Recovery and Active Learning. Int J Wirel Inf Netw. 2017 Jun; 24(2):109-123. PMID: 29983539.
    Citations:    
  41. McHill AW, Klerman EB, Slater B, Kangarloo T, Mankowski PW, Shaw ND. The Relationship Between Estrogen and the Decline in Delta Power During Adolescence. Sleep. 2017 03 01; 40(3). PMID: 28364433.
    Citations: 3     Fields:    Translation:Humans
  42. Bianchi MT, Phillips AJ, Wang W, Klerman EB. Statistics for Sleep and Biological Rhythms Research. J Biol Rhythms. 2017 02; 32(1):7-17. PMID: 27836938.
    Citations: 3     Fields:    Translation:Humans
  43. Klerman EB, Wang W, Phillips AJ, Bianchi MT. Statistics for Sleep and Biological Rhythms Research. J Biol Rhythms. 2017 02; 32(1):18-25. PMID: 27836939.
    Citations: 4     Fields:    Translation:HumansAnimals
  44. Klerman EB, Beckett SA, Landrigan CP. Applying mathematical models to predict resident physician performance and alertness on traditional and novel work schedules. BMC Med Educ. 2016 Sep 13; 16(1):239. PMID: 27623842.
    Citations: 8     Fields:    Translation:Humans
  45. Shaw ND, McHill AW, Schiavon M, Kangarloo T, Mankowski PW, Cobelli C, Klerman EB, Hall JE. Effect of Slow Wave Sleep Disruption on Metabolic Parameters in Adolescents. Sleep. 2016 Aug 01; 39(8):1591-9. PMID: 27166229.
    Citations: 9     Fields:    Translation:Humans
  46. Bendrick GA, Beckett SA, Klerman EB. Human fatigue and the crash of the airship Italia. Polar Res. 2016; 35(1). PMID: 28490834.
    Citations: 1     
  47. Bermudez EB, Klerman EB, Czeisler CA, Cohen DA, Wyatt JK, Phillips AJ. Prediction of Vigilant Attention and Cognitive Performance Using Self-Reported Alertness, Circadian Phase, Hours since Awakening, and Accumulated Sleep Loss. PLoS One. 2016; 11(3):e0151770. PMID: 27019198.
    Citations: 9     Fields:    Translation:Humans
  48. Lane JM, Chang AM, Bjonnes AC, Aeschbach D, Anderson C, Cade BE, Cain SW, Czeisler CA, Gharib SA, Gooley JJ, Gottlieb DJ, Grant SF, Klerman EB, Lauderdale DS, Lockley SW, Munch M, Patel S, Punjabi NM, Rajaratnam SM, Rueger M, St Hilaire MA, Santhi N, Scheuermaier K, Van Reen E, Zee PC, Shea SA, Duffy JF, Buxton OM, Redline S, Scheer FA, Saxena R. Impact of Common Diabetes Risk Variant in MTNR1B on Sleep, Circadian, and Melatonin Physiology. Diabetes. 2016 06; 65(6):1741-51. PMID: 26868293.
    Citations: 25     Fields:    Translation:Humans
  49. Sano A, Phillips AJ, Yu AZ, McHill AW, Taylor S, Jaques N, Czeisler CA, Klerman EB, Picard RW. Recognizing Academic Performance, Sleep Quality, Stress Level, and Mental Health using Personality Traits, Wearable Sensors and Mobile Phones. Int Conf Wearable Implant Body Sens Netw. 2015 Jun; 2015. PMID: 28516162.
    Citations: 19     
  50. Vijayan S, Klerman EB, Adler GK, Kopell NJ. Thalamic mechanisms underlying alpha-delta sleep with implications for fibromyalgia. J Neurophysiol. 2015 Sep; 114(3):1923-30. PMID: 26245315.
    Citations: 1     Fields:    Translation:HumansCells
  51. Faghih RT, Dahleh MA, Adler GK, Klerman EB, Brown EN. Quantifying Pituitary-Adrenal Dynamics and Deconvolution of Concurrent Cortisol and Adrenocorticotropic Hormone Data by Compressed Sensing. IEEE Trans Biomed Eng. 2015 Oct; 62(10):2379-88. PMID: 25935025.
    Citations: 3     Fields:    Translation:Humans
  52. Sano A, Yu AZ, McHill AW, Phillips AJ, Taylor S, Jaques N, Klerman EB, Picard RW. Prediction of Happy-Sad mood from daily behaviors and previous sleep history. Annu Int Conf IEEE Eng Med Biol Soc. 2015; 2015:6796-9. PMID: 26737854.
    Citations: 4     Translation:Humans
  53. Dean DA, Adler GK, Nguyen DP, Klerman EB. Biological time series analysis using a context free language: applicability to pulsatile hormone data. PLoS One. 2014; 9(9):e104087. PMID: 25184442.
    Citations: 2     Fields:    Translation:Humans
  54. Faghih RT, Dahleh MA, Adler GK, Klerman EB, Brown EN. Deconvolution of serum cortisol levels by using compressed sensing. PLoS One. 2014; 9(1):e85204. PMID: 24489656.
    Citations: 7     Fields:    Translation:Humans
  55. Balasubramanian R, Cohen DA, Klerman EB, Pignatelli D, Hall JE, Dwyer AA, Czeisler CA, Pitteloud N, Crowley WF. Absence of central circadian pacemaker abnormalities in humans with loss of function mutation in prokineticin 2. J Clin Endocrinol Metab. 2014 Mar; 99(3):E561-6. PMID: 24423319.
    Citations: 2     Fields:    Translation:Humans
  56. Phillips AJ, Fulcher BD, Robinson PA, Klerman EB. Mammalian rest/activity patterns explained by physiologically based modeling. PLoS Comput Biol. 2013; 9(9):e1003213. PMID: 24039566.
    Citations: 7     Fields:    Translation:Animals
  57. Breslow ER, Phillips AJ, Huang JM, St Hilaire MA, Klerman EB. A mathematical model of the circadian phase-shifting effects of exogenous melatonin. J Biol Rhythms. 2013 Feb; 28(1):79-89. PMID: 23382594.
    Citations: 5     Fields:    Translation:HumansCells
  58. Phillips AJ, Robinson PA, Klerman EB. Arousal state feedback as a potential physiological generator of the ultradian REM/NREM sleep cycle. J Theor Biol. 2013 Feb 21; 319:75-87. PMID: 23220346.
    Citations: 5     Fields:    Translation:Humans
  59. Bianchi MT, Wang W, Klerman EB. Sleep misperception in healthy adults: implications for insomnia diagnosis. J Clin Sleep Med. 2012 Oct 15; 8(5):547-54. PMID: 23066367.
    Citations: 10     Fields:    Translation:Humans
  60. St Hilaire MA, Sullivan JP, Anderson C, Cohen DA, Barger LK, Lockley SW, Klerman EB. Classifying performance impairment in response to sleep loss using pattern recognition algorithms on single session testing. Accid Anal Prev. 2013 Jan; 50:992-1002. PMID: 22959616.
    Citations: 2     Fields:    Translation:Humans
  61. Klerman EB, Wang W, Duffy JF, Dijk DJ, Czeisler CA, Kronauer RE. Survival analysis indicates that age-related decline in sleep continuity occurs exclusively during NREM sleep. Neurobiol Aging. 2013 Jan; 34(1):309-18. PMID: 22727943.
    Citations: 17     Fields:    Translation:Humans
  62. Klerman H, St Hilaire MA, Kronauer RE, Gooley JJ, Gronfier C, Hull JT, Lockley SW, Santhi N, Wang W, Klerman EB. Analysis method and experimental conditions affect computed circadian phase from melatonin data. PLoS One. 2012; 7(4):e33836. PMID: 22511928.
    Citations: 8     Fields:    Translation:Humans
  63. Phillips AJ, Czeisler CA, Klerman EB. Revisiting spontaneous internal desynchrony using a quantitative model of sleep physiology. J Biol Rhythms. 2011 Oct; 26(5):441-53. PMID: 21921298.
    Citations: 12     Fields:    Translation:Humans
  64. Klingman KM, Marsh EE, Klerman EB, Anderson EJ, Hall JE. Absence of circadian rhythms of gonadotropin secretion in women. J Clin Endocrinol Metab. 2011 May; 96(5):1456-61. PMID: 21346063.
    Citations: 9     Fields:    Translation:Humans
  65. Citi L, Bianchi MT, Klerman EB, Barbieri R. Instantaneous monitoring of sleep fragmentation by point process heart rate variability and respiratory dynamics. Annu Int Conf IEEE Eng Med Biol Soc. 2011; 2011:7735-8. PMID: 22256131.
    Citations: 3     Translation:Humans
  66. Cohen DA, Wang W, Klerman EB, Rajaratnam SM. Ramelteon prior to a short evening nap impairs neurobehavioral performance for up to 12 hours after awakening. J Clin Sleep Med. 2010 Dec 15; 6(6):565-71. PMID: 21206545.
    Citations: 4     Fields:    Translation:Humans
  67. Diniz Behn CG, Klerman EB, Mochizuki T, Lin SC, Scammell TE. Abnormal sleep/wake dynamics in orexin knockout mice. Sleep. 2010 Mar; 33(3):297-306. PMID: 20337187.
    Citations: 42     Fields:    Translation:AnimalsCells
  68. Cohen DA, Wang W, Wyatt JK, Kronauer RE, Dijk DJ, Czeisler CA, Klerman EB. Uncovering residual effects of chronic sleep loss on human performance. Sci Transl Med. 2010 Jan 13; 2(14):14ra3. PMID: 20371466.
    Citations: 77     Fields:    Translation:Humans
  69. Dean DA, Forger DB, Klerman EB. Taking the lag out of jet lag through model-based schedule design. PLoS Comput Biol. 2009 Jun; 5(6):e1000418. PMID: 19543382.
    Citations: 12     Fields:    Translation:Humans
  70. Rajaratnam SM, Polymeropoulos MH, Fisher DM, Roth T, Scott C, Birznieks G, Klerman EB. Melatonin agonist tasimelteon (VEC-162) for transient insomnia after sleep-time shift: two randomised controlled multicentre trials. Lancet. 2009 Feb 07; 373(9662):482-91. PMID: 19054552.
    Citations: 43     Fields:    Translation:HumansCTClinical Trials
  71. Klerman EB, Dijk DJ. Age-related reduction in the maximal capacity for sleep--implications for insomnia. Curr Biol. 2008 Aug 05; 18(15):1118-23. PMID: 18656358.
    Citations: 52     Fields:    Translation:Humans
  72. Benloucif S, Burgess HJ, Klerman EB, Lewy AJ, Middleton B, Murphy PJ, Parry BL, Revell VL. Measuring melatonin in humans. J Clin Sleep Med. 2008 Feb 15; 4(1):66-9. PMID: 18350967.
    Citations: 109     Fields:    Translation:Humans
  73. St Hilaire MA, Gronfier C, Zeitzer JM, Klerman EB. A physiologically based mathematical model of melatonin including ocular light suppression and interactions with the circadian pacemaker. J Pineal Res. 2007 Oct; 43(3):294-304. PMID: 17803528.
    Citations: 16     Fields:    Translation:Humans
  74. Kronauer RE, Gunzelmann G, Van Dongen HP, Doyle FJ, Klerman EB. Uncovering physiologic mechanisms of circadian rhythms and sleep/wake regulation through mathematical modeling. J Biol Rhythms. 2007 Jun; 22(3):233-45. PMID: 17517913.
    Citations: 4     Fields:    Translation:HumansAnimals
  75. Dean DA, Fletcher A, Hursh SR, Klerman EB. Developing mathematical models of neurobehavioral performance for the "real world". J Biol Rhythms. 2007 Jun; 22(3):246-58. PMID: 17517914.
    Citations: 7     Fields:    Translation:Humans
  76. St Hilaire MA, Klerman EB, Khalsa SB, Wright KP, Czeisler CA, Kronauer RE. Addition of a non-photic component to a light-based mathematical model of the human circadian pacemaker. J Theor Biol. 2007 Aug 21; 247(4):583-99. PMID: 17531270.
    Citations: 20     Fields:    Translation:HumansAnimals
  77. Klerman EB, St Hilaire M. On mathematical modeling of circadian rhythms, performance, and alertness. J Biol Rhythms. 2007 Apr; 22(2):91-102. PMID: 17440211.
    Citations: 11     Fields:    Translation:Humans
  78. St. Hilaire MA, Klerman EB. Inter-individual variability in the parameters of a mathematical model of neurobehavioral performance and alertness. Sleep. 2007; 30:A52.
  79. Mochizuki T, Klerman EB, Sakurai T, Scammell TE. Elevated body temperature during sleep in orexin knockout mice. . 2006 Sep; 291(3):R533-40. PMID: 16556901.
    Citations: 29     Translation:Animals
  80. Indic P, Gurdziel K, Kronauer RE, Klerman EB. Development of a two-dimension manifold to represent high dimension mathematical models of the intracellular Mammalian circadian clock. J Biol Rhythms. 2006 Jun; 21(3):222-32. PMID: 16731662.
    Citations: 7     Fields:    Translation:Animals
  81. St. Hilaire MA, Gronfier C, Klerman EB. Addition of a light effect to a physiologically-based model of melatonin. Society for Research in Biological Rhythms biannual meeting. 2006; 8:153.
  82. Rajaratnam SMW, Polymeropoulos MH, Fisher DM, Scott CH, Birznieks G, Klerman EB. Phase-advancing human circadian rhythms with the dual MT1/MT2 melatonin agonist VEC-162. Society for Research in Biological Rhythms biannual meeting. 2006; 8:66.
  83. Rajaratnam SMW, Ronda JM, Polymeropoulos MH, Fisher DM, Scott CH, Birznieks G, Klerman EB. The melatonin agonist VEC-162 immediately phase-advances the human circadian system. Sleep. 2006; (in press).
  84. Dean II DA, Klerman EB, Barger LK, Livingston G. Understanding Bayesian network structure sensitivity in classifiers derived from human experimental data. Life Science Society Computational Systems Bioinformatics Conference. 2006; (in press).
  85. Klerman EB, Dijk DJ. Aging: Asymptotic sleep duration during extended sleep opportunities. Sleep. 2006; 19:A35.
  86. Hall JE, Dean DA, Smith PC, Klerman EB. Sleep attenuates LH/GnRH pulse frequency in the luteal as well as the early follicular phase in normal women. Endocrine Society Annual Meeting. 2006; #853816.
  87. Klerman EB, Dijk DJ. Aging: Changes in mood and performance during sleep extension in younger and older people. Sleep. 2006; 29:A374.
  88. Dean II DA, Barger LK, Livingston G, Czeisler CA, Klerman EB. Using Bayesian networks to understand individual differences that affect the use of actigraphy as a predictor of sleep. Sleep. 2006; 29:A69.
  89. Klerman EB, Dean DA, Smith PC, Hall JE. The relationship between LH interpulse interval and amplitude in influenced by cycle phase, but not by sleep in adult women. Society for Research in Biological Rhythms biannual meeting. 2006; 8:49.
  90. St. Hilaire MA, Klerman EB. A tool to analyze melatonin phase and amplitude using a physiologically-based model of melatonin. Sleep. 2006; 19:A53-A54.
  91. Klerman EB, Dijk DJ. Interindividual variation in sleep duration and its association with sleep debt in young adults. Sleep. 2005 Oct; 28(10):1253-9. PMID: 16295210.
    Citations: 38     Fields:    Translation:Humans
  92. Klerman EB. Clinical aspects of human circadian rhythms. J Biol Rhythms. 2005 Aug; 20(4):375-86. PMID: 16077156.
    Citations: 32     Fields:    Translation:Humans
  93. Dean DA, Forger DB, Klerman EB. Designing optimal light intervention schedules for experimental and operational settings. Sleep. 2005; 28:A69.
  94. Dean DA, Klerman EB. Using domain specific information to design optimal circadian adjustment schedules. Computation Physiology: from Genome to Physiom Symposium, 35th International Congress of Physiological Sciences. 2005.
  95. Indic P, Forger DB, St Hilaire MA, Dean DA, Brown EN, Kronauer RE, Klerman EB, Jewett ME. Comparison of amplitude recovery dynamics of two limit cycle oscillator models of the human circadian pacemaker. Chronobiol Int. 2005; 22(4):613-29. PMID: 16147894.
    Citations: 6     Fields:    Translation:Humans
  96. St. Hilaire MA, Klerman EB, Lockley SW, Brainard GC, Kronauer RE. Revision of a mathematical model of circadian photic resetting to incorporate spectral sensitivity. Sleep. 2005; 28:A56.
  97. Klerman EB, Davis JB, Duffy JF, Dijk DJ, Kronauer RE. Older people awaken more frequently but fall back asleep at the same rate as younger people. Sleep. 2004 Jun 15; 27(4):793-8. PMID: 15283016.
    Citations: 18     Fields:    Translation:Humans
  98. Gurdziel K, Kronauer RE, Shiromani PJ, Klerman EB. Age related differences in sleep state transitions and transition duration in rats before and after sleep deprivation. Sleep. 2004; A140.
  99. Klerman EB, Dijk DJ. Regulation of sleep during the day and at night during a bedrest extension protocol in older and younger individuals. Society for Research on Biological Rhythms. 2004; 9:190-191.
  100. Mazza MC, Dijk DJ, Klerman EB. Alertness and performance in older and younger adults during 16, 28, and 52 hours of sleep deprivation. Sleep. 2004; A154-155.
  101. Klerman EB, Hall JE. Sleep related slowing of LH pulses in the luteal phase of the menstrual cycle. Sleep. 2004; A40.
  102. Klerman EB, Hall JE. Differential effect of sleep disruption on menstrual cycle dynamics. Society for Research on Biological Rhythms. 2004; 9:46.
  103. Klerman EB, Dijk D-J. Sleep during a bedrest extension protocol in older and younger individuals. Sleep. 2004; A129-130.
  104. Dean DA, Mazza MC, Wyatt JK, Czeisler CA, Klerman EB. Circadian and homeostatic components of mathematical models of neurobehavioral performance for the effects of low dose caffeine during a 42-hour forced desynchrony protocol. Sleep. 2004; A77-78.
  105. Klerman EB, Adler GK, Jin M, Maliszewski AM, Brown EN. A statistical model of diurnal variation in human growth hormone. Am J Physiol Endocrinol Metab. 2003 Nov; 285(5):E1118-26. PMID: 12888486.
    Citations: 4     Fields:    Translation:Humans
  106. Klerman EB, Shanahan TL, Brotman DJ, Rimmer DW, Emens JS, Rizzo JF, Czeisler CA. Photic resetting of the human circadian pacemaker in the absence of conscious vision. J Biol Rhythms. 2002 Dec; 17(6):548-55. PMID: 12465888.
    Citations: 37     Fields:    Translation:Humans
  107. Klerman EB, Gershengorn HB, Duffy JF, Kronauer RE. Comparisons of the variability of three markers of the human circadian pacemaker. J Biol Rhythms. 2002 Apr; 17(2):181-93. PMID: 12002165.
    Citations: 111     Fields:    Translation:HumansCTClinical Trials
  108. Duffy JF, Zeitzer JM, Rimmer DW, Klerman EB, Dijk DJ, Czeisler CA. Peak of circadian melatonin rhythm occurs later within the sleep of older subjects. Am J Physiol Endocrinol Metab. 2002 Feb; 282(2):E297-303. PMID: 11788360.
    Citations: 50     Fields:    Translation:Humans
  109. Klerman EB, Zeitzer JM, Duffy JF, Khalsa SB, Czeisler CA. Absence of an increase in the duration of the circadian melatonin secretory episode in totally blind human subjects. J Clin Endocrinol Metab. 2001 Jul; 86(7):3166-70. PMID: 11443183.
    Citations: 4     Fields:    Translation:Humans
  110. Klerman EB, Goldenberg DL, Brown EN, Maliszewski AM, Adler GK. Circadian rhythms of women with fibromyalgia. J Clin Endocrinol Metab. 2001 Mar; 86(3):1034-9. PMID: 11238482.
    Citations: 25     Fields:    Translation:Humans
  111. Klerman EB. Non-photic effects on the circadian system: results from experiements in blind and sighted individuals. Zeitgebers, Entrainment and Masking of the Circadian System. Honma K, Honma S, eds. 2001; 155-169.
  112. Klerman EB, Duffy JF, Dijk DJ, Czeisler CA. Circadian phase resetting in older people by ocular bright light exposure. J Investig Med. 2001 Jan; 49(1):30-40. PMID: 11217145.
    Citations: 18     Fields:    Translation:Humans
  113. Klerman EB, Boulos Z, Edgar DM, Mistlberger RE, Moore-Ede MC. EEG delta activity during undisturbed sleep in the squirrel monkey. Sleep Res Online. 2000; 3(3):113-9. PMID: 11382909.
    Citations: 1     Fields:    Translation:Animals
  114. Klerman EB, Jewett ME. Commentary: model building, quantitative testing, and model comparison. J Biol Rhythms. 1999 Dec; 14(6):621-4. PMID: 10643761.
    Citations: 2     Fields:    
  115. Zeitzer JM, Daniels JE, Duffy JF, Klerman EB, Shanahan TL, Dijk DJ, Czeisler CA. Do plasma melatonin concentrations decline with age? Am J Med. 1999 Nov; 107(5):432-6. PMID: 10569297.
    Citations: 35     Fields:    Translation:Humans
  116. Klerman EB, Lee Y, Czeisler CA, Kronauer RE. Linear demasking techniques are unreliable for estimating the circadian phase of ambulatory temperature data. J Biol Rhythms. 1999 Aug; 14(4):260-74. PMID: 10447306.
    Citations: 10     Fields:    Translation:Humans
  117. Klerman EB, Boulos Z, Edgar DM, Mistlberger RE, Moore-Ede MC. Circadian and homeostatic influences on sleep in the squirrel monkey: sleep after sleep deprivation. Sleep. 1999 Feb 01; 22(1):45-59. PMID: 9989365.
    Citations: 5     Fields:    Translation:Animals
  118. Czeisler CA, Klerman EB. Circadian and sleep-dependent regulation of hormone release in humans. Recent Prog Horm Res. 1999; 54:97-130; discussion 130-2. PMID: 10548874.
    Citations: 71     Fields:    Translation:Humans
  119. Duffy JF, Dijk DJ, Klerman EB, Czeisler CA. Later endogenous circadian temperature nadir relative to an earlier wake time in older people. Am J Physiol. 1998 Nov; 275(5 Pt 2):R1478-87. PMID: 9791064.
    Citations: 69     Fields:    Translation:Humans
  120. Klerman EB, Rimmer DW, Dijk DJ, Kronauer RE, Rizzo JF, Czeisler CA. Nonphotic entrainment of the human circadian pacemaker. Am J Physiol. 1998 Apr; 274(4 Pt 2):R991-6. PMID: 9575961.
    Citations: 32     Fields:    Translation:Humans
  121. Jewett ME, Rimmer DW, Duffy JF, Klerman EB, Kronauer RE, Czeisler CA. Human circadian pacemaker is sensitive to light throughout subjective day without evidence of transients. Am J Physiol. 1997 Nov; 273(5 Pt 2):R1800-9. PMID: 9374826.
    Citations: 28     Fields:    Translation:Humans
  122. el-Hajj Fuleihan G, Klerman EB, Brown EN, Choe Y, Brown EM, Czeisler CA. The parathyroid hormone circadian rhythm is truly endogenous--a general clinical research center study. J Clin Endocrinol Metab. 1997 Jan; 82(1):281-6. PMID: 8989274.
    Citations: 34     Fields:    Translation:Humans
  123. Klerman EB, Dijk DJ, Kronauer RE, Czeisler CA. Simulations of light effects on the human circadian pacemaker: implications for assessment of intrinsic period. Am J Physiol. 1996 Jan; 270(1 Pt 2):R271-82. PMID: 8769811.
    Citations: 20     Fields:    Translation:Humans
  124. Czeisler CA, Shanahan TL, Klerman EB, Martens H, Brotman DJ, Emens JS, Klein T, Rizzo JF. Suppression of melatonin secretion in some blind patients by exposure to bright light. N Engl J Med. 1995 Jan 05; 332(1):6-11. PMID: 7990870.
    Citations: 91     Fields:    Translation:HumansCTClinical Trials
  125. Klerman EB. Selective NREM Sleep Deprivation. Carskadon MA, editor. Encyclopedia of Sleep and Dreaming. 1993; 177-178.
  126. Klerman EB. Circadian and Homeostatic Regulation of Sleep in the Squirrel Monkey. 1990.
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