Harvard Catalyst Profiles

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Dennis Hyong-Kyun Kim, Ph.D., M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AT008764 (KIM, DENNIS H) Sep 30, 2014 - Aug 31, 2019
    NIH/NCCIH
    Antimicrobial discovery from metabolomics of nematode pathogen interactions
    Role: Principal Investigator
  2. R01GM084477 (KIM, DENNIS H) Sep 1, 2007 - Jun 30, 2021
    NIH/NIGMS
    Microbial Modulation of Neuroendocrine Physiology and Aging of C. elegans
    Role: Principal Investigator
  3. K08AI053595 (KIM, DENNIS H) May 1, 2003 - Sep 30, 2005
    NIH/NIAID
    Genetic analysis of innate immunity in C elegans
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Park J, Meisel JD, Kim DH. Immediate activation of chemosensory neuron gene expression by bacterial metabolites is selectively induced by distinct cyclic GMP-dependent pathways in Caenorhabditis elegans. PLoS Genet. 2020 08; 16(8):e1008505. PMID: 32776934.
    Citations:    
  2. Wong SS, Yu J, Schroeder FC, Kim DH. Population Density Modulates the Duration of Reproduction of C. elegans. Curr Biol. 2020 Jul 06; 30(13):2602-2607.e2. PMID: 32442457.
    Citations:    
  3. Fletcher M, Tillman EJ, Butty VL, Levine SS, Kim DH. Global transcriptional regulation of innate immunity by ATF-7 in C. elegans. PLoS Genet. 2019 02; 15(2):e1007830. PMID: 30789901.
    Citations:    
  4. Kim DH. Bacterial Siderophores Promote Animal Host Iron Acquisition and Growth. Cell. 2018 10 04; 175(2):311-312. PMID: 30290138.
    Citations:    
  5. Tillman EJ, Richardson CE, Cattie DJ, Reddy KC, Lehrbach NJ, Droste R, Ruvkun G, Kim DH. Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of Caenorhabditis elegans. Genetics. 2018 12; 210(4):1329-1337. PMID: 30287474.
    Citations:    Fields:    
  6. Kim DH, Ewbank JJ. Signaling in the innate immune response. WormBook. 2018 08 14; 2018:1-35. PMID: 26694508.
    Citations: 8     Fields:    Translation:AnimalsCells
  7. Hilbert ZA, Kim DH. PDF-1 neuropeptide signaling regulates sexually dimorphic gene expression in shared sensory neurons of C. elegans. Elife. 2018 07 19; 7. PMID: 30024377.
    Citations:    
  8. Kulalert W, Sadeeshkumar H, Zhang YK, Schroeder FC, Kim DH. Molecular Determinants of the Regulation of Development and Metabolism by Neuronal eIF2a Phosphorylation in Caenorhabditis elegans. Genetics. 2017 05; 206(1):251-263. PMID: 28292919.
    Citations:    Fields:    Translation:AnimalsCells
  9. Hilbert ZA, Kim DH. Sexually dimorphic control of gene expression in sensory neurons regulates decision-making behavior in C. elegans. Elife. 2017 01 24; 6. PMID: 28117661.
    Citations: 2     Fields:    Translation:AnimalsCells
  10. Fletcher M, Kim DH. Age-Dependent Neuroendocrine Signaling from Sensory Neurons Modulates the Effect of Dietary Restriction on Longevity of Caenorhabditis elegans. PLoS Genet. 2017 01; 13(1):e1006544. PMID: 28107363.
    Citations:    Fields:    Translation:AnimalsCells
  11. Cattie DJ, Richardson CE, Reddy KC, Ness-Cohn EM, Droste R, Thompson MK, Gilbert WV, Kim DH. Mutations in Nonessential eIF3k and eIF3l Genes Confer Lifespan Extension and Enhanced Resistance to ER Stress in Caenorhabditis elegans. PLoS Genet. 2016 09; 12(9):e1006326. PMID: 27690135.
    Citations: 5     Fields:    Translation:Animals
  12. Kim DH. IRE1 Sulfenylation by Reactive Oxygen Species Coordinates Cellular Stress Signaling. Mol Cell. 2016 08 18; 63(4):541-542. PMID: 27540852.
    Citations:    
  13. Meisel JD, Kim DH. Inhibition of Lithium-Sensitive Phosphatase BPNT-1 Causes Selective Neuronal Dysfunction in C. elegans. Curr Biol. 2016 07 25; 26(14):1922-8. PMID: 27397889.
    Citations: 4     Fields:    Translation:AnimalsCells
  14. Kim DH. Signal Transduction: A Different Kind of Toll Is in the BAG. Curr Biol. 2015 Aug 31; 25(17):R767-9. PMID: 26325140.
    Citations:    
  15. Pagano DJ, Kingston ER, Kim DH. Tissue expression pattern of PMK-2 p38 MAPK is established by the miR-58 family in C. elegans. PLoS Genet. 2015 Feb; 11(2):e1004997. PMID: 25671546.
    Citations: 7     Fields:    Translation:AnimalsCells
  16. Meisel JD, Panda O, Mahanti P, Schroeder FC, Kim DH. Chemosensation of bacterial secondary metabolites modulates neuroendocrine signaling and behavior of C. elegans. Cell. 2014 Oct 09; 159(2):267-80. PMID: 25303524.
    Citations: 27     Fields:    Translation:AnimalsCells
  17. Meisel JD, Kim DH. Behavioral avoidance of pathogenic bacteria by Caenorhabditis elegans. Trends Immunol. 2014 Oct; 35(10):465-70. PMID: 25240986.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  18. Kulalert W, Kim DH. The unfolded protein response in a pair of sensory neurons promotes entry of C. elegans into dauer diapause. Curr Biol. 2013 Dec 16; 23(24):2540-5. PMID: 24316205.
    Citations: 4     Fields:    Translation:AnimalsCells
  19. Kim DH. Bacteria and the aging and longevity of Caenorhabditis elegans. Annu Rev Genet. 2013; 47:233-46. PMID: 24274752.
    Citations: 12     Fields:    Translation:AnimalsCells
  20. Richardson CE, Kinkel S, Kim DH. Physiological IRE-1-XBP-1 and PEK-1 signaling in Caenorhabditis elegans larval development and immunity. PLoS Genet. 2011 Nov; 7(11):e1002391. PMID: 22125500.
    Citations: 24     Fields:    Translation:AnimalsCells
  21. Chang HC, Paek J, Kim DH. Natural polymorphisms in C. elegans HECW-1 E3 ligase affect pathogen avoidance behaviour. Nature. 2011 Nov 16; 480(7378):525-9. PMID: 22089131.
    Citations: 22     Fields:    Translation:AnimalsCells
  22. Reddy KC, Hunter RC, Bhatla N, Newman DK, Kim DH. Caenorhabditis elegans NPR-1-mediated behaviors are suppressed in the presence of mucoid bacteria. Proc Natl Acad Sci U S A. 2011 Aug 02; 108(31):12887-92. PMID: 21768378.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  23. Youngman MJ, Rogers ZN, Kim DH. A decline in p38 MAPK signaling underlies immunosenescence in Caenorhabditis elegans. PLoS Genet. 2011 May; 7(5):e1002082. PMID: 21625567.
    Citations: 25     Fields:    Translation:AnimalsCells
  24. Shivers RP, Pagano DJ, Kooistra T, Richardson CE, Reddy KC, Whitney JK, Kamanzi O, Matsumoto K, Hisamoto N, Kim DH. Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegans. PLoS Genet. 2010 Apr 01; 6(4):e1000892. PMID: 20369020.
    Citations: 53     Fields:    Translation:AnimalsCells
  25. Richardson CE, Kooistra T, Kim DH. An essential role for XBP-1 in host protection against immune activation in C. elegans. Nature. 2010 Feb 25; 463(7284):1092-5. PMID: 20182512.
    Citations: 110     Fields:    Translation:HumansAnimalsCells
  26. Shivers RP, Kooistra T, Chu SW, Pagano DJ, Kim DH. Tissue-specific activities of an immune signaling module regulate physiological responses to pathogenic and nutritional bacteria in C. elegans. Cell Host Microbe. 2009 Oct 22; 6(4):321-30. PMID: 19837372.
    Citations: 43     Fields:    Translation:AnimalsCells
  27. Powell JR, Kim DH, Ausubel FM. The G protein-coupled receptor FSHR-1 is required for the Caenorhabditis elegans innate immune response. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2782-7. PMID: 19196974.
    Citations: 37     Fields:    Translation:AnimalsCells
  28. Reddy KC, Andersen EC, Kruglyak L, Kim DH. A polymorphism in npr-1 is a behavioral determinant of pathogen susceptibility in C. elegans. Science. 2009 Jan 16; 323(5912):382-4. PMID: 19150845.
    Citations: 80     Fields:    Translation:AnimalsCells
  29. Kim D. Studying host-pathogen interactions and innate immunity in Caenorhabditis elegans. Dis Model Mech. 2008 Nov-Dec; 1(4-5):205-8. PMID: 19093025.
    Citations: 8     Fields:    Translation:AnimalsCells
  30. Shivers RP, Youngman MJ, Kim DH. Transcriptional responses to pathogens in Caenorhabditis elegans. Curr Opin Microbiol. 2008 Jun; 11(3):251-6. PMID: 18567532.
    Citations: 31     Fields:    Translation:AnimalsCells
  31. Troemel ER, Chu SW, Reinke V, Lee SS, Ausubel FM, Kim DH. p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans. PLoS Genet. 2006 Nov 10; 2(11):e183. PMID: 17096597.
    Citations: 206     Fields:    Translation:AnimalsCells
  32. Kim DH, Ausubel FM. Evolutionary perspectives on innate immunity from the study of Caenorhabditis elegans. Curr Opin Immunol. 2005 Feb; 17(1):4-10. PMID: 15653303.
    Citations: 49     Fields:    Translation:AnimalsCells
  33. Kim DH, Liberati NT, Mizuno T, Inoue H, Hisamoto N, Matsumoto K, Ausubel FM. Integration of Caenorhabditis elegans MAPK pathways mediating immunity and stress resistance by MEK-1 MAPK kinase and VHP-1 MAPK phosphatase. Proc Natl Acad Sci U S A. 2004 Jul 27; 101(30):10990-4. PMID: 15256594.
    Citations: 53     Fields:    Translation:AnimalsCells
  34. Mizuno T, Hisamoto N, Terada T, Kondo T, Adachi M, Nishida E, Kim DH, Ausubel FM, Matsumoto K. The Caenorhabditis elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signaling pathway in stress response. EMBO J. 2004 Jun 02; 23(11):2226-34. PMID: 15116070.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  35. Liberati NT, Fitzgerald KA, Kim DH, Feinbaum R, Golenbock DT, Ausubel FM. Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response. Proc Natl Acad Sci U S A. 2004 Apr 27; 101(17):6593-8. PMID: 15123841.
    Citations: 64     Fields:    Translation:AnimalsCells
  36. Garsin DA, Villanueva JM, Begun J, Kim DH, Sifri CD, Calderwood SB, Ruvkun G, Ausubel FM. Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens. Science. 2003 Jun 20; 300(5627):1921. PMID: 12817143.
    Citations: 185     Fields:    Translation:AnimalsCells
  37. Kim DH, Feinbaum R, Alloing G, Emerson FE, Garsin DA, Inoue H, Tanaka-Hino M, Hisamoto N, Matsumoto K, Tan MW, Ausubel FM. A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity. Science. 2002 Jul 26; 297(5581):623-6. PMID: 12142542.
    Citations: 247     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.