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Krolewski, Andrzej
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Andrzej Stefan Krolewski, Ph.D., M.D.
Title
Professor of Medicine
Institution
Joslin Diabetes Center
Department
Medicine
Address
Joslin Diabetes Center
One Joslin Place
Boston MA 02215
Phone
617/732-2668
Fax
617/732-2667
vCard
Download vCard
(
login for email
)
completed student projects
|
research activities and funding
|
selected publications
|
Mentoring
completed student projects
The Role of Carboxypeptidase A in Conferring Susceptibility to Diabetic Nephropathy in Type I Diabetics
Summer, 06/21/99 - 08/21/99
Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can
login
to make corrections and additions.
Most Recent
|
List All
R01DK126799
(KROLEWSKI, ANDRZEJ S)
Sep 20, 2021 - Jul 31, 2025
NIH
Development of Prognostic Algorithms to Identify Subjects at High Risk of ESKD in Type 2 Diabetes
Role: Principal Investigator
DP3DK112177
(KROLEWSKI, ANDRZEJ S)
Sep 20, 2016 - Aug 31, 2019
NIH
Search for biomarkers to measure progression of diabetic nephropathy in Type 1 diabetes; application of proteomics technologies
Role: Principal Investigator
R24DK090961
(KING, GEORGE L)
Sep 30, 2010 - Aug 31, 2013
NIH
Protective Factors Against the Development of Microvascular Complications
Role: Co-Principal Investigator
R01DK077532
(KROLEWSKI, ANDRZEJ S)
Sep 30, 2006 - Aug 31, 2010
NIH
Mapping Genes for End-Stage Renal Disease in Type 1 Diabetes
Role: Principal Investigator
R01DK067638
(KROLEWSKI, ANDRZEJ S)
Jul 1, 2004 - Jun 30, 2010
NIH
The Urinary Proteome and Renal Function Loss in Diabetes
Role: Principal Investigator
R01DK058549
(KROLEWSKI, ANDRZEJ S)
Dec 1, 2000 - Jun 30, 2013
NIH
Mapping genes for proteinuria in type II diabetes
Role: Principal Investigator
R03TW001351
(KROLEWSKI, ANDRZEJ S)
Sep 1, 2000 - Jun 30, 2006
NIH
NIDDM GENE SEARCH ON CHROMOSOME 20Q IN POLISH FAMILIES
Role: Principal Investigator
R01DK053534
(KROLEWSKI, ANDRZEJ S)
Apr 23, 1998 - Jan 31, 2003
NIH
MAPPING GENES FOR NEPHROPATHY IN IDDM
Role: Principal Investigator
R01DK047475
(KROLEWSKI, ANDRZEJ S)
Feb 27, 1996 - Jun 30, 2007
NIH
Identification of Susceptibility Genes for NIDDM
Role: Principal Investigator
R01DK041526
(KROLEWSKI, ANDRZEJ S)
Feb 1, 1990 - Apr 30, 2020
NIH
Tumor necrosis factor superfamily of ligands and receptors in progressive renal decline in diabetes
Role: Principal Investigator
F33DK008033
(KROLEWSKI, ANDRZEJ S)
Dec 1, 1987
NIH
MAPPING TYPE II DIABETES GENES THROUGH LINKAGE STUDIES
Role: Principal Investigator
R01DK039782
(KROLEWSKI, ANDRZEJ S)
Sep 30, 1987 - Aug 31, 1990
NIH
GENETIC FACTORS IN DIABETIC NEPHROPATHY--SIB-PAIR STUDY
Role: Principal Investigator
P50DK039249
(BRENNER, BARRY M)
Sep 1, 1987 - Jul 31, 1992
NIH
HARVARD CENTER FOR THE STUDY OF KIDNEY DISEASE
Role: Principal Investigator
P30DK036836
(KING, GEORGE L)
Sep 30, 1986 - Mar 31, 2022
NIH
Diabetes Research Center
Role: Co-Principal Investigator
Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can
login
to make corrections and additions.
Newest
|
Oldest
|
Most Cited
|
Most Discussed
|
Timeline
|
Field Summary
|
Plain Text
PMC Citations
indicate the number of times the publication was cited by articles in PubMed Central, and the
Altmetric
score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.)
Fields
are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation
tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Mychaleckyj JC, Valo E,
Ichimura T
, Ahluwalia TS, Dina C, Miller RG, Shabalin IG, Gyorgy B, Cao J, Onengut-Gumuscu S,
Satake E
, Smiles AM, Haukka JK, Tregouet DA, Costacou T, O'Neil K, Paterson AD, Forsblom C, Keenan HA, Pezzolesi MG, Pragnell M, Galecki A, Rich SS, Sandholm N, Klein R, Klein BE, Susztak K, Orchard TJ, Korstanje R,
King GL
, Hadjadj S, Rossing P,
Bonventre JV
, Groop PH, Warram JH,
Krolewski AS
. Association of Coding Variants in Hydroxysteroid 17-beta Dehydrogenase 14 (HSD17B14) with Reduced Progression to End Stage Kidney Disease in Type 1 Diabetes. J Am Soc Nephrol. 2021 10; 32(10):2634-2651.
PMID:
34261756
.
Citations:
1
Fields:
Nep
Nephrology
Translation:
Humans
Animals
Cells
Md Dom ZI
,
Satake E
, Skupien J, Krolewski B, O'Neil K, Willency JA,
Dillon ST
, Wilson JM,
Kobayashi H
, Ihara K,
Libermann TA
, Pragnell M, Duffin KL,
Krolewski AS
. Circulating proteins protect against renal decline and progression to end-stage renal disease in patients with diabetes. Sci Transl Med. 2021 06 30; 13(600).
PMID:
34193611
.
Citations:
3
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
Satake E
, Saulnier PJ,
Kobayashi H
, Gupta MK, Looker HC, Wilson JM,
Md Dom ZI
, Ihara K, O'Neil K, Krolewski B, Pipino C, Pavkov ME, Nair V, Bitzer M,
Niewczas MA
, Kretzler M, Mauer M,
Doria A
, Najafian B,
Kulkarni RN
, Duffin KL, Pezzolesi MG,
Kahn CR
, Nelson RG,
Krolewski AS
. Comprehensive Search for Novel Circulating miRNAs and Axon Guidance Pathway Proteins Associated with Risk of ESKD in Diabetes. J Am Soc Nephrol. 2021 09; 32(9):2331-2351.
PMID:
34140396
.
Citations:
4
Fields:
Nep
Nephrology
Translation:
Humans
Md Dom ZI
, Pipino C, Krolewski B, O'Neil K,
Satake E
,
Krolewski AS
. Effect of TNFa stimulation on expression of kidney risk inflammatory proteins in human umbilical vein endothelial cells cultured in hyperglycemia. Sci Rep. 2021 05 27; 11(1):11133.
PMID:
34045516
.
Citations:
Fields:
Sci
Science
Translation:
Humans
Cells
Ihara K, Skupien J,
Kobayashi H
,
Md Dom ZI
, Wilson JM, O'Neil K, Badger HS, Bowsman LM,
Satake E
, Breyer MD, Duffin KL,
Krolewski AS
. Erratum. Profibrotic Circulating Proteins and Risk of Early Progressive Renal Decline in Patients With Type 2 Diabetes With and Without Albuminuria. Diabetes Care 2020;43:2760-2767. Diabetes Care. 2021 Feb; 44(2):631.
PMID:
33334811
.
Citations:
2
Fields:
End
Endocrinology
Ihara K, Skupien J,
Kobayashi H
,
Md Dom ZI
, Wilson JM, O'Neil K, Badger HS, Bowsman LM,
Satake E
, Breyer MD, Duffin KL,
Krolewski AS
. Profibrotic Circulating Proteins and Risk of Early Progressive Renal Decline in Patients With Type 2 Diabetes With and Without Albuminuria. Diabetes Care. 2020 11; 43(11):2760-2767.
PMID:
32887710
.
Citations:
5
Fields:
End
Endocrinology
Translation:
Humans
Ihara K, Skupien J, Krolewski B,
Md Dom ZI
, O'Neil K,
Satake E
,
Kobayashi H
, Rashidi NM,
Niewczas MA
,
Krolewski AS
. A profile of multiple circulating tumor necrosis factor receptors associated with early progressive kidney decline in Type 1 Diabetes is similar to profiles in autoimmune disorders. Kidney Int. 2021 03; 99(3):725-736.
PMID:
32717193
.
Citations:
5
Fields:
Nep
Nephrology
Translation:
Humans
Salem RM, Todd JN, Sandholm N, Cole JB, Chen WM, Andrews D, Pezzolesi MG, McKeigue PM, Hiraki LT, Qiu C, Nair V, Di Liao C, Cao JJ, Valo E, Onengut-Gumuscu S, Smiles AM, McGurnaghan SJ, Haukka JK, Harjutsalo V, Brennan EP, van Zuydam N, Ahlqvist E, Doyle R, Ahluwalia TS, Lajer M, Hughes MF, Park J, Skupien J, Spiliopoulou A, Liu A, Menon R, Boustany-Kari CM, Kang HM, Nelson RG, Klein R, Klein BE, Lee KE, Gao X, Mauer M, Maestroni S, Caramori ML, de Boer IH, Miller RG, Guo J, Boright AP, Tregouet D, Gyorgy B, Snell-Bergeon JK, Maahs DM, Bull SB, Canty AJ, Palmer CNA, Stechemesser L, Paulweber B, Weitgasser R, Sokolovska J, Rovite V, Pirags V, Prakapiene E, Radzeviciene L, Verkauskiene R, Panduru NM, Groop LC, McCarthy MI, Gu HF, Möllsten A, Falhammar H, Brismar K, Martin F, Rossing P, Costacou T, Zerbini G, Marre M, Hadjadj S, McKnight AJ, Forsblom C, McKay G, Godson C, Maxwell AP, Kretzler M, Susztak K, Colhoun HM,
Krolewski A
, Paterson AD, Groop PH, Rich SS,
Hirschhorn JN
,
Florez JC
. Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen. J Am Soc Nephrol. 2019 10; 30(10):2000-2016.
PMID:
31537649
.
Citations:
47
Fields:
Nep
Nephrology
Translation:
Humans
Cells
Niewczas MA
, Pavkov ME, Skupien J, Smiles A,
Md Dom ZI
, Wilson JM, Park J, Nair V, Schlafly A, Saulnier PJ,
Satake E
, Simeone CA,
Shah H
, Qiu C, Looker HC,
Fiorina P
, Ware CF,
Sun JK
,
Doria A
, Kretzler M, Susztak K, Duffin KL, Nelson RG,
Krolewski AS
. A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes. Nat Med. 2019 05; 25(5):805-813.
PMID:
31011203
.
Citations:
92
Fields:
Med
Medicine (General)
Mol
Molecular Biology
Translation:
Humans
Skupien J, Smiles AM, Valo E, Ahluwalia TS, Gyorgy B, Sandholm N, Croall S, Lajer M, McDonnell K, Forsblom C, Harjutsalo V, Marre M, Galecki AT, Tregouet DA, Wu CY, Mychaleckyj JC, Nickerson H, Pragnell M, Rich SS, Pezzolesi MG, Hadjadj S, Rossing P, Groop PH,
Krolewski AS
. Variations in Risk of End-Stage Renal Disease and Risk of Mortality in an International Study of Patients With Type 1 Diabetes and Advanced Nephropathy. Diabetes Care. 2019 01; 42(1):93-101.
PMID:
30455333
.
Citations:
11
Fields:
End
Endocrinology
Translation:
Humans
Nabity MB, Polli JW,
Vaidya V
,
Krolewski A
, Glaab WE. New Frontiers: Approaches to Understand the Mechanistic Basis of Renal Toxicity. Toxicol Pathol. 2018 12; 46(8):1002-1005.
PMID:
30189777
.
Citations:
Fields:
Pat
Pathology
Tox
Toxicology
Translation:
Humans
Animals
van Zuydam NR, Ahlqvist E, Sandholm N, Deshmukh H, Rayner NW, Abdalla M, Ladenvall C, Ziemek D, Fauman E, Robertson NR, McKeigue PM, Valo E, Forsblom C, Harjutsalo V, Perna A, Rurali E, Marcovecchio ML, Igo RP, Salem RM, Perico N, Lajer M, Käräjämäki A, Imamura M, Kubo M, Takahashi A, Sim X, Liu J,
van Dam RM
, Jiang G, Tam CHT, Luk AOY, Lee HM, Lim CKP, Szeto CC, So WY, Chan JCN, Ang SF, Dorajoo R, Wang L, Clara TSH, McKnight AJ, Duffy S, Pezzolesi MG, Marre M, Gyorgy B, Hadjadj S, Hiraki LT, Ahluwalia TS, Almgren P, Schulz CA, Orho-Melander M, Linneberg A, Christensen C, Witte DR, Grarup N, Brandslund I, Melander O, Paterson AD, Tregouet D, Maxwell AP, Lim SC, Ma RCW, Tai ES, Maeda S, Lyssenko V, Tuomi T,
Krolewski AS
, Rich SS,
Hirschhorn JN
,
Florez JC
, Dunger D, Pedersen O, Hansen T, Rossing P, Remuzzi G, Brosnan MJ, Palmer CNA, Groop PH, Colhoun HM, Groop LC, McCarthy MI. A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes. Diabetes. 2018 07; 67(7):1414-1427.
PMID:
29703844
.
Citations:
47
Fields:
End
Endocrinology
Translation:
Humans
Satake E
, Pezzolesi MG,
Md Dom ZI
, Smiles AM,
Niewczas MA
,
Krolewski AS
. Circulating miRNA Profiles Associated With Hyperglycemia in Patients With Type 1 Diabetes. Diabetes. 2018 05; 67(5):1013-1023.
PMID:
29453204
.
Citations:
31
Fields:
End
Endocrinology
Translation:
Humans
Cells
Nowak N, Skupien J, Smiles AM, Yamanouchi M,
Niewczas MA
, Galecki AT, Duffin KL, Breyer MD, Pullen N,
Bonventre JV
,
Krolewski AS
. Markers of early progressive renal decline in type 2 diabetes suggest different implications for etiological studies and prognostic tests development. Kidney Int. 2018 05; 93(5):1198-1206.
PMID:
29398132
.
Citations:
39
Fields:
Nep
Nephrology
Translation:
Humans
Niewczas MA
,
Krolewski AS
. Response to Comment on Niewczas et al. Circulating Modified Metabolites and a Risk of ESRD in Patients With Type 1 Diabetes and Chronic Kidney Disease. Diabetes Care 2017;40:383-390. Diabetes Care. 2017 08; 40(8):e109-e110.
PMID:
28733381
.
Citations:
Fields:
End
Endocrinology
Translation:
Humans
Yamanouchi M, Skupien J,
Niewczas MA
, Smiles AM,
Doria A
,
Stanton RC
, Galecki AT, Duffin KL, Pullen N, Breyer MD,
Bonventre JV
, Warram JH,
Krolewski AS
. Improved clinical trial enrollment criterion to identify patients with diabetes at risk of end-stage renal disease. Kidney Int. 2017 07; 92(1):258-266.
PMID:
28396115
.
Citations:
18
Fields:
Nep
Nephrology
Translation:
Humans
Krolewski AS
, Skupien J, Rossing P, Warram JH. Fast renal decline to end-stage renal disease: an unrecognized feature of nephropathy in diabetes. Kidney Int. 2017 06; 91(6):1300-1311.
PMID:
28366227
.
Citations:
72
Fields:
Nep
Nephrology
Translation:
Humans
Niewczas MA
, Mathew AV, Croall S, Byun J, Major M, Sabisetti VS, Smiles A,
Bonventre JV
, Pennathur S,
Krolewski AS
. Circulating Modified Metabolites and a Risk of ESRD in Patients With Type 1 Diabetes and Chronic Kidney Disease. Diabetes Care. 2017 Mar; 40(3):383-390.
PMID:
28087576
.
Citations:
35
Fields:
End
Endocrinology
Translation:
Humans
Sandholm N, Van Zuydam N, Ahlqvist E, Juliusdottir T, Deshmukh HA, Rayner NW, Di Camillo B, Forsblom C, Fadista J, Ziemek D, Salem RM, Hiraki LT, Pezzolesi M, Trégouët D, Dahlström E, Valo E, Oskolkov N, Ladenvall C, Marcovecchio ML, Cooper J, Sambo F, Malovini A, Manfrini M, McKnight AJ, Lajer M, Harjutsalo V, Gordin D, Parkkonen M, Tuomilehto J, Lyssenko V, McKeigue PM, Rich SS, Brosnan MJ, Fauman E, Bellazzi R, Rossing P, Hadjadj S,
Krolewski A
, Paterson AD,
Florez JC
,
Hirschhorn JN
, Maxwell AP, Dunger D, Cobelli C, Colhoun HM, Groop L, McCarthy MI, Groop PH. The Genetic Landscape of Renal Complications in Type 1 Diabetes. J Am Soc Nephrol. 2017 02; 28(2):557-574.
PMID:
27647854
.
Citations:
46
Fields:
Nep
Nephrology
Translation:
Humans
Skupien J, Warram JH, Smiles AM,
Stanton RC
,
Krolewski AS
. Patterns of Estimated Glomerular Filtration Rate Decline Leading to End-Stage Renal Disease in Type 1 Diabetes. Diabetes Care. 2016 Dec; 39(12):2262-2269.
PMID:
27647852
.
Citations:
15
Fields:
End
Endocrinology
Translation:
Humans
Nowak N, Skupien J,
Niewczas MA
, Yamanouchi M, Major M, Croall S, Smiles A, Warram JH,
Bonventre JV
,
Krolewski AS
. Increased plasma kidney injury molecule-1 suggests early progressive renal decline in non-proteinuric patients with type 1 diabetes. Kidney Int. 2016 Feb; 89(2):459-67.
PMID:
26509588
.
Citations:
47
Fields:
Nep
Nephrology
Translation:
Humans
Pavkov ME, Weil EJ, Fufaa GD, Nelson RG, Lemley KV, Knowler WC,
Niewczas MA
,
Krolewski AS
. Tumor necrosis factor receptors 1 and 2 are associated with early glomerular lesions in type 2 diabetes. Kidney Int. 2016 Jan; 89(1):226-34.
PMID:
26398493
.
Citations:
27
Fields:
Nep
Nephrology
Translation:
Humans
Cells
Orlov S, Cherney DZ, Pop-Busui R, Lovblom LE, Ficociello LH, Smiles AM, Warram JH,
Krolewski AS
, Perkins BA. Cardiac autonomic neuropathy and early progressive renal decline in patients with nonmacroalbuminuric type 1 diabetes. Clin J Am Soc Nephrol. 2015 Jul 07; 10(7):1136-44.
PMID:
26092828
.
Citations:
18
Fields:
Nep
Nephrology
Translation:
Humans
Krolewski AS
. Progressive renal decline: the new paradigm of diabetic nephropathy in type 1 diabetes. Diabetes Care. 2015 Jun; 38(6):954-62.
PMID:
25998286
.
Citations:
72
Fields:
End
Endocrinology
Translation:
Humans
Pezzolesi MG,
Satake E
, McDonnell KP, Major M, Smiles AM,
Krolewski AS
. Circulating TGF-ß1-Regulated miRNAs and the Risk of Rapid Progression to ESRD in Type 1 Diabetes. Diabetes. 2015 Sep; 64(9):3285-93.
PMID:
25931475
.
Citations:
37
Fields:
End
Endocrinology
Translation:
Humans
Caramori ML, Kim Y, Goldfine AB, Moore JH, Rich SS, Mychaleckyj JC, Kirkpatrick D, Nickerson H,
Krolewski AS
, Mauer M. Differential Gene Expression in Diabetic Nephropathy in Individuals With Type 1 Diabetes. J Clin Endocrinol Metab. 2015 Jun; 100(6):E876-82.
PMID:
25871838
.
Citations:
13
Fields:
End
Endocrinology
Met
Metabolism
Translation:
Humans
Cells
Pavkov ME, Nelson RG, Knowler WC, Cheng Y,
Krolewski AS
,
Niewczas MA
. Elevation of circulating TNF receptors 1 and 2 increases the risk of end-stage renal disease in American Indians with type 2 diabetes. Kidney Int. 2015 Apr; 87(4):812-9.
PMID:
25272234
.
Citations:
54
Fields:
Nep
Nephrology
Translation:
Humans
Sabbisetti VS
,
Waikar SS
, Antoine DJ, Smiles A, Wang C, Ravisankar A, Ito K, Sharma S, Ramadesikan S, Lee M, Briskin R, De Jager PL, Ngo TT, Radlinski M, Dear JW, Park KB,
Betensky R
,
Krolewski AS
,
Bonventre JV
. Blood kidney injury molecule-1 is a biomarker of acute and chronic kidney injury and predicts progression to ESRD in type I diabetes. J Am Soc Nephrol. 2014 Oct; 25(10):2177-86.
PMID:
24904085
.
Citations:
140
Fields:
Nep
Nephrology
Translation:
Humans
Animals
Skupien J, Warram JH, Smiles A, Galecki A,
Stanton RC
,
Krolewski AS
. Improved glycemic control and risk of ESRD in patients with type 1 diabetes and proteinuria. J Am Soc Nephrol. 2014 Dec; 25(12):2916-25.
PMID:
24904086
.
Citations:
18
Fields:
Nep
Nephrology
Translation:
Humans
Skupien J, Warram JH,
Niewczas MA
, Gohda T, Malecki M, Mychaleckyj JC, Galecki AT,
Krolewski AS
. Synergism between circulating tumor necrosis factor receptor 2 and HbA(1c) in determining renal decline during 5-18 years of follow-up in patients with type 1 diabetes and proteinuria. Diabetes Care. 2014 Sep; 37(9):2601-8.
PMID:
24898299
.
Citations:
23
Fields:
End
Endocrinology
Translation:
Humans
Fiorina P
, Vergani A, Bassi R,
Niewczas MA
, Altintas MM, Pezzolesi MG, D'Addio F, Chin M, Tezza S, Ben Nasr M, Mattinzoli D, Ikehata M, Corradi D,
Schumacher V
, Buvall L, Yu CC, Chang JM, La Rosa S, Finzi G, Solini A, Vincenti F, Rastaldi MP, Reiser J,
Krolewski AS
, Mundel PH,
Sayegh MH
. Role of podocyte B7-1 in diabetic nephropathy. J Am Soc Nephrol. 2014 Jul; 25(7):1415-29.
PMID:
24676639
.
Citations:
57
Fields:
Nep
Nephrology
Translation:
Humans
Animals
Cells
Niewczas MA
, Sirich TL, Mathew AV, Skupien J, Mohney RP, Warram JH, Smiles A, Huang X, Walker W, Byun J, Karoly ED, Kensicki EM,
Berry GT
,
Bonventre JV
, Pennathur S, Meyer TW,
Krolewski AS
. Uremic solutes and risk of end-stage renal disease in type 2 diabetes: metabolomic study. Kidney Int. 2014 May; 85(5):1214-24.
PMID:
24429397
.
Citations:
89
Fields:
Nep
Nephrology
Translation:
Humans
Krolewski AS
, Gohda T,
Niewczas MA
. Progressive renal decline as the major feature of diabetic nephropathy in type 1 diabetes. Clin Exp Nephrol. 2014 Aug; 18(4):571-83.
PMID:
24218296
.
Citations:
12
Fields:
Nep
Nephrology
Translation:
Humans
Animals
Pezzolesi MG,
Krolewski AS
. Diabetic nephropathy: is ESRD its only heritable phenotype? J Am Soc Nephrol. 2013 Oct; 24(10):1505-7.
PMID:
24029425
.
Citations:
5
Fields:
Nep
Nephrology
Translation:
Humans
Cells
Qi L
,
Qi Q
, Prudente S, Mendonca C, Andreozzi F, di Pietro N, Sturma M, Novelli V, Mannino GC, Formoso G,
Gervino EV
,
Hauser TH
,
Muehlschlegel JD
,
Niewczas MA
,
Krolewski AS
, Biolo G, Pandolfi A,
Rimm E
, Sesti G, Trischitta V,
Hu F
,
Doria A
. Association between a genetic variant related to glutamic acid metabolism and coronary heart disease in individuals with type 2 diabetes. JAMA. 2013 Aug 28; 310(8):821-8.
PMID:
23982368
.
Citations:
54
Fields:
Med
Medicine (General)
Translation:
Humans
Cells
Krolewski AS
,
Niewczas MA
, Skupien J, Gohda T, Smiles A, Eckfeldt JH,
Doria A
, Warram JH. Early progressive renal decline precedes the onset of microalbuminuria and its progression to macroalbuminuria. Diabetes Care. 2014; 37(1):226-34.
PMID:
23939543
.
Citations:
111
Fields:
End
Endocrinology
Translation:
Humans
Skupien J, Warram JH, Groop PH,
Krolewski AS
. Cystatin-based estimated GFR versus creatinine-based and creatinine- and cystatin-based estimated GFR for ESRD and mortality risk in diabetes. Am J Kidney Dis. 2013 Jul; 62(1):184-6.
PMID:
23684753
.
Citations:
4
Fields:
Nep
Nephrology
Translation:
Humans
Pezzolesi MG, Jeong J, Smiles AM, Skupien J, Mychaleckyj JC, Rich SS, Warram JH,
Krolewski AS
. Family-based association analysis confirms the role of the chromosome 9q21.32 locus in the susceptibility of diabetic nephropathy. PLoS One. 2013; 8(3):e60301.
PMID:
23555951
.
Citations:
10
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
Cells
Lee JE, Gohda T, Walker WH, Skupien J, Smiles AM, Holak RR, Jeong J, McDonnell KP,
Krolewski AS
,
Niewczas MA
. Risk of ESRD and all cause mortality in type 2 diabetes according to circulating levels of FGF-23 and TNFR1. PLoS One. 2013; 8(3):e58007.
PMID:
23526964
.
Citations:
18
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
Wanic K, Krolewski B, Ju W, Placha G,
Niewczas MA
, Walker W, Warram JH, Kretzler M,
Krolewski AS
. Transcriptome analysis of proximal tubular cells (HK-2) exposed to urines of type 1 diabetes patients at risk of early progressive renal function decline. PLoS One. 2013; 8(3):e57751.
PMID:
23505438
.
Citations:
4
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
Cells
Merchant ML,
Niewczas MA
, Ficociello LH, Lukenbill JA, Wilkey DW, Li M, Khundmiri SJ, Warram JH,
Krolewski AS
, Klein JB. Plasma kininogen and kininogen fragments are biomarkers of progressive renal decline in type 1 diabetes. Kidney Int. 2013 Jun; 83(6):1177-84.
PMID:
23466993
.
Citations:
21
Fields:
Nep
Nephrology
Translation:
Humans
Animals
Cells
Martini S, Nair V, Patel SR, Eichinger F, Nelson RG, Weil EJ, Pezzolesi MG,
Krolewski AS
, Randolph A, Keller BJ, Werner T, Kretzler M. From single nucleotide polymorphism to transcriptional mechanism: a model for FRMD3 in diabetic nephropathy. Diabetes. 2013 Jul; 62(7):2605-12.
PMID:
23434934
.
Citations:
27
Fields:
End
Endocrinology
Translation:
Humans
Cells
Pezzolesi MG,
Krolewski AS
. The genetic risk of kidney disease in type 2 diabetes. Med Clin North Am. 2013 Jan; 97(1):91-107.
PMID:
23290732
.
Citations:
18
Fields:
Med
Medicine (General)
Translation:
Humans
Krolewski AS
,
Bonventre JV
. High risk of ESRD in type 1 diabetes: new strategies are needed to retard progressive renal function decline. Semin Nephrol. 2012 Sep; 32(5):407-14.
PMID:
23062980
.
Citations:
15
Fields:
Nep
Nephrology
Translation:
Humans
Krolewski AS
,
Bonventre JV
. High risk of ESRD in type 1 diabetes: call for action: introduction. Semin Nephrol. 2012 Sep; 32(5):405-6.
PMID:
23062979
.
Citations:
1
Fields:
Nep
Nephrology
Translation:
Humans
Krolewski AS
, Warram JH, Forsblom C, Smiles AM, Thorn L, Skupien J, Harjutsalo V,
Stanton R
, Eckfeldt JH, Inker LA, Groop PH. Serum concentration of cystatin C and risk of end-stage renal disease in diabetes. Diabetes Care. 2012 Nov; 35(11):2311-6.
PMID:
22851596
.
Citations:
35
Fields:
End
Endocrinology
Translation:
Humans
Skupien J, Warram JH, Smiles AM,
Niewczas MA
, Gohda T, Pezzolesi MG, Cantarovich D,
Stanton R
,
Krolewski AS
. The early decline in renal function in patients with type 1 diabetes and proteinuria predicts the risk of end-stage renal disease. Kidney Int. 2012 Sep; 82(5):589-97.
PMID:
22622493
.
Citations:
58
Fields:
Nep
Nephrology
Translation:
Humans
Perkins BA, Rabbani N, Weston A, Ficociello LH, Adaikalakoteswari A,
Niewczas M
, Warram J,
Krolewski AS
, Thornalley P. Serum levels of advanced glycation endproducts and other markers of protein damage in early diabetic nephropathy in type 1 diabetes. PLoS One. 2012; 7(4):e35655.
PMID:
22558190
.
Citations:
25
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
Gohda T, Walker WH, Wolkow P, Lee JE, Warram JH,
Krolewski AS
,
Niewczas MA
. Elevated urinary excretion of immunoglobulins in nonproteinuric patients with type 1 diabetes. Am J Physiol Renal Physiol. 2012 Jul 01; 303(1):F157-62.
PMID:
22513848
.
Citations:
11
Fields:
Nep
Nephrology
Phy
Physiology
Translation:
Humans
Niewczas MA
, Gohda T, Skupien J, Smiles AM, Walker WH, Rosetti F, Cullere X, Eckfeldt JH,
Doria A
,
Mayadas TN
, Warram JH,
Krolewski AS
. Circulating TNF receptors 1 and 2 predict ESRD in type 2 diabetes. J Am Soc Nephrol. 2012 Mar; 23(3):507-15.
PMID:
22266663
.
Citations:
213
Fields:
Nep
Nephrology
Translation:
Humans
Cells
Gohda T,
Niewczas MA
, Ficociello LH, Walker WH, Skupien J, Rosetti F, Cullere X, Johnson AC, Crabtree G, Smiles AM,
Mayadas TN
, Warram JH,
Krolewski AS
. Circulating TNF receptors 1 and 2 predict stage 3 CKD in type 1 diabetes. J Am Soc Nephrol. 2012 Mar; 23(3):516-24.
PMID:
22266664
.
Citations:
166
Fields:
Nep
Nephrology
Translation:
Humans
Cells
Doria A
,
Krolewski AS
. Diabetes: Lowering serum uric acid levels to prevent kidney failure. Nat Rev Nephrol. 2011 Aug 02; 7(9):495-6.
PMID:
21808278
.
Citations:
6
Fields:
Nep
Nephrology
Translation:
Humans
Pezzolesi MG, Poznik GD, Skupien J, Smiles AM, Mychaleckyj JC, Rich SS, Warram JH,
Krolewski AS
. An intergenic region on chromosome 13q33.3 is associated with the susceptibility to kidney disease in type 1 and 2 diabetes. Kidney Int. 2011 Jul; 80(1):105-11.
PMID:
21412220
.
Citations:
16
Fields:
Nep
Nephrology
Translation:
Humans
Cells
Rosolowsky ET, Skupien J, Smiles AM,
Niewczas M
, Roshan B,
Stanton R
, Eckfeldt JH, Warram JH,
Krolewski AS
. Risk for ESRD in type 1 diabetes remains high despite renoprotection. J Am Soc Nephrol. 2011 Mar; 22(3):545-53.
PMID:
21355053
.
Citations:
88
Fields:
Nep
Nephrology
Translation:
Humans
Kure M, Pezzolesi MG, Poznik GD, Katavetin P, Skupien J, Dunn JS, Mychaleckyj JC, Warram JH,
Krolewski AS
. Genetic variation in the matrix metalloproteinase genes and diabetic nephropathy in type 1 diabetes. Mol Genet Metab. 2011 May; 103(1):60-5.
PMID:
21277817
.
Citations:
6
Fields:
Bio
Biochemistry
Met
Metabolism
Mol
Molecular Biology
Translation:
Humans
Vaidya VS
,
Niewczas MA
, Ficociello LH, Johnson AC, Collings FB, Warram JH,
Krolewski AS
,
Bonventre JV
. Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers, kidney injury molecule-1, and N-acetyl-ß-D-glucosaminidase. Kidney Int. 2011 Feb; 79(4):464-70.
PMID:
20980978
.
Citations:
102
Fields:
Nep
Nephrology
Translation:
Humans
Good DM, Zürbig P, Argilés A, Bauer HW, Behrens G, Coon JJ, Dakna M, Decramer S, Delles C, Dominiczak AF, Ehrich JH, Eitner F, Fliser D, Frommberger M, Ganser A, Girolami MA, Golovko I, Gwinner W, Haubitz M, Herget-Rosenthal S, Jankowski J, Jahn H, Jerums G, Julian BA, Kellmann M, Kliem V, Kolch W,
Krolewski AS
, Luppi M, Massy Z, Melter M, Neusüss C, Novak J, Peter K, Rossing K, Rupprecht H, Schanstra JP, Schiffer E, Stolzenburg JU, Tarnow L, Theodorescu D, Thongboonkerd V, Vanholder R, Weissinger EM, Mischak H, Schmitt-Kopplin P. Naturally occurring human urinary peptides for use in diagnosis of chronic kidney disease. Mol Cell Proteomics. 2010 Nov; 9(11):2424-37.
PMID:
20616184
.
Citations:
160
Fields:
Bio
Biochemistry
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Liew CW, Bochenski J, Kawamori D, Hu J, Leech CA, Wanic K, Malecki M, Warram JH, Qi L,
Krolewski AS
,
Kulkarni RN
. The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells. J Clin Invest. 2010 Aug; 120(8):2876-88.
PMID:
20592469
.
Citations:
66
Fields:
Med
Medicine (General)
Translation:
Humans
Animals
Cells
Ficociello LH, Rosolowsky ET,
Niewczas MA
, Maselli NJ, Weinberg JM, Aschengrau A, Eckfeldt JH,
Stanton RC
, Galecki AT,
Doria A
, Warram JH,
Krolewski AS
. High-normal serum uric acid increases risk of early progressive renal function loss in type 1 diabetes: results of a 6-year follow-up. Diabetes Care. 2010 Jun; 33(6):1337-43.
PMID:
20332356
.
Citations:
86
Fields:
End
Endocrinology
Translation:
Humans
Pezzolesi MG, Skupien J, Mychaleckyj JC, Warram JH,
Krolewski AS
. Insights to the genetics of diabetic nephropathy through a genome-wide association study of the GoKinD collection. Semin Nephrol. 2010 Mar; 30(2):126-40.
PMID:
20347642
.
Citations:
12
Fields:
Nep
Nephrology
Translation:
Humans
Animals
Perkins BA, Ficociello LH, Roshan B, Warram JH,
Krolewski AS
. In patients with type 1 diabetes and new-onset microalbuminuria the development of advanced chronic kidney disease may not require progression to proteinuria. Kidney Int. 2010 Jan; 77(1):57-64.
PMID:
19847154
.
Citations:
104
Fields:
Nep
Nephrology
Translation:
Humans
Tsaih SW, Pezzolesi MG, Yuan R, Warram JH,
Krolewski AS
, Korstanje R. Genetic analysis of albuminuria in aging mice and concordance with loci for human diabetic nephropathy found in a genome-wide association scan. Kidney Int. 2010 Feb; 77(3):201-10.
PMID:
19924099
.
Citations:
22
Fields:
Nep
Nephrology
Translation:
Humans
Animals
Borowiec M, Liew CW, Thompson R, Boonyasrisawat W, Hu J, Mlynarski WM, El Khattabi I, Kim SH, Marselli L, Rich SS,
Krolewski AS
,
Bonner-Weir S
, Sharma A, Sale M, Mychaleckyj JC,
Kulkarni RN
,
Doria A
. Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14460-5.
PMID:
19667185
.
Citations:
60
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Pezzolesi MG, Katavetin P, Kure M, Poznik GD, Skupien J, Mychaleckyj JC, Rich SS, Warram JH,
Krolewski AS
. Confirmation of genetic associations at ELMO1 in the GoKinD collection supports its role as a susceptibility gene in diabetic nephropathy. Diabetes. 2009 Nov; 58(11):2698-702.
PMID:
19651817
.
Citations:
61
Fields:
End
Endocrinology
Translation:
Humans
Merchant ML, Perkins BA, Boratyn GM, Ficociello LH, Wilkey DW, Barati MT, Bertram CC, Page GP, Rovin BH, Warram JH,
Krolewski AS
, Klein JB. Urinary peptidome may predict renal function decline in type 1 diabetes and microalbuminuria. J Am Soc Nephrol. 2009 Sep; 20(9):2065-74.
PMID:
19643930
.
Citations:
56
Fields:
Nep
Nephrology
Translation:
Humans
Cells
Perkins BA,
Aiello LP
,
Krolewski AS
. Diabetes complications and the renin-angiotensin system. N Engl J Med. 2009 Jul 02; 361(1):83-5.
PMID:
19571288
.
Citations:
9
Fields:
Med
Medicine (General)
Translation:
Humans
Perkins BA,
Krolewski AS
. Early nephropathy in type 1 diabetes: the importance of early renal function decline. Curr Opin Nephrol Hypertens. 2009 May; 18(3):233-40.
PMID:
19300247
.
Citations:
18
Fields:
Nep
Nephrology
Vas
Vascular Diseases
Translation:
Humans
Pezzolesi MG, Poznik GD, Mychaleckyj JC, Paterson AD, Barati MT, Klein JB, Ng DP, Placha G, Canani LH, Bochenski J, Waggott D, Merchant ML, Krolewski B, Mirea L, Wanic K, Katavetin P, Kure M, Wolkow P, Dunn JS, Smiles A, Walker WH, Boright AP, Bull SB,
Doria A
, Rogus JJ, Rich SS, Warram JH,
Krolewski AS
. Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes. Diabetes. 2009 Jun; 58(6):1403-10.
PMID:
19252134
.
Citations:
137
Fields:
End
Endocrinology
Translation:
Humans
Ficociello LH, Perkins BA, Roshan B, Weinberg JM, Aschengrau A, Warram JH,
Krolewski AS
. Renal hyperfiltration and the development of microalbuminuria in type 1 diabetes. Diabetes Care. 2009 May; 32(5):889-93.
PMID:
19196883
.
Citations:
35
Fields:
End
Endocrinology
Translation:
Humans
Tsaih S, Pezzolesi MG, Yuan R, Warram JH,
Krolewski AS
, Korstanje R. Genetic analysis of albuminuria in the aging mouse and concordance with loci for diabetic nephropathy found in a genome-wide association scan. J Am Soc Neph. 2009; Submitted.
Ficociello LH, Rosolowsky ET, Niewczas M, Maselli NJ, Roshan B, Weinberg JM, Aschengrau A, Stanton RC, Doria D, Warram JH,
Krolewski AS
. Serum Uric Acid and Early Renal Function Decline in Patients with Type 1 Diabetes and Microalbuminuria. Kidney Int. 2009; (accepted for publication).
Merchant ML, Perkins BA, Boratyn GM, Ficociello LH, Wilkey DW, Barati MT, Bertram CC, Page GP, Rovin BH, Warram JH,
Krolewski AS
(senior author), Klein JB. Urinary petidome analysis and early renal function decline in type 1 diabetics with microalbuminuria. J Am Soc Nephrol. 2009; (accepted for publication).
Niewczas MA
, Ficociello LH, Johnson AC, Walker W, Rosolowsky ET, Roshan B, Warram JH,
Krolewski AS
. Serum concentrations of markers of TNFalpha and Fas-mediated pathways and renal function in nonproteinuric patients with type 1 diabetes. Clin J Am Soc Nephrol. 2009 Jan; 4(1):62-70.
PMID:
19073786
.
Citations:
69
Fields:
Nep
Nephrology
Translation:
Humans
Cells
Rosolowsky ET,
Niewczas MA
, Ficociello LH, Perkins BA, Warram JH,
Krolewski AS
. Between hyperfiltration and impairment: demystifying early renal functional changes in diabetic nephropathy. Diabetes Res Clin Pract. 2008 Nov 13; 82 Suppl 1:S46-53.
PMID:
18849087
.
Citations:
16
Fields:
End
Endocrinology
Translation:
Humans
Wanic K, Placha G, Dunn J, Smiles A, Warram JH,
Krolewski AS
. Exclusion of polymorphisms in carnosinase genes (CNDP1 and CNDP2) as a cause of diabetic nephropathy in type 1 diabetes: results of large case-control and follow-up studies. Diabetes. 2008 Sep; 57(9):2547-51.
PMID:
18753673
.
Citations:
25
Fields:
End
Endocrinology
Translation:
Humans
Cells
Rogus JJ, Poznik GD, Pezzolesi MG, Smiles AM, Dunn J, Walker W, Wanic K, Moczulski D, Canani L, Araki S, Makita Y, Warram JH,
Krolewski AS
. High-density single nucleotide polymorphism genome-wide linkage scan for susceptibility genes for diabetic nephropathy in type 1 diabetes: discordant sibpair approach. Diabetes. 2008 Sep; 57(9):2519-26.
PMID:
18559660
.
Citations:
23
Fields:
End
Endocrinology
Translation:
Humans
Cells
Ng DP, Nurbaya S, Ye SH,
Krolewski AS
. An IL-6 haplotype on human chromosome 7p21 confers risk for impaired renal function in type 2 diabetic patients. Kidney Int. 2008 Aug; 74(4):521-7.
PMID:
18496509
.
Citations:
13
Fields:
Nep
Nephrology
Translation:
Humans
Cells
Rosolowsky ET, Ficociello LH, Maselli NJ,
Niewczas MA
, Binns AL, Roshan B, Warram JH,
Krolewski AS
. High-normal serum uric acid is associated with impaired glomerular filtration rate in nonproteinuric patients with type 1 diabetes. Clin J Am Soc Nephrol. 2008 May; 3(3):706-13.
PMID:
18272826
.
Citations:
60
Fields:
Nep
Nephrology
Translation:
Humans
Cells
Ng DP, Nurbaya S, Choo S, Koh D, Chia KS,
Krolewski AS
. Genetic variation at the SLC12A3 locus is unlikely to explain risk for advanced diabetic nephropathy in Caucasians with type 2 diabetes. Nephrol Dial Transplant. 2008 Jul; 23(7):2260-4.
PMID:
18263927
.
Citations:
7
Fields:
Nep
Nephrology
Tra
Transplantation
Translation:
Humans
Wolkow PP,
Niewczas MA
, Perkins B, Ficociello LH, Lipinski B, Warram JH,
Krolewski AS
. Association of urinary inflammatory markers and renal decline in microalbuminuric type 1 diabetics. J Am Soc Nephrol. 2008 Apr; 19(4):789-97.
PMID:
18256362
.
Citations:
68
Fields:
Nep
Nephrology
Translation:
Humans
Wanic K, Malecki MT, Klupa T, Warram JH, Sieradzki J,
Krolewski AS
. Lack of association between polymorphisms in the gene encoding protein tyrosine phosphatase 1B (PTPN1) and risk of Type 2 diabetes. Diabet Med. 2007 Jun; 24(6):650-5.
PMID:
17403124
.
Citations:
2
Fields:
End
Endocrinology
Translation:
Humans
Ficociello LH, Perkins BA, Silva KH,
Finkelstein DM
, Ignatowska-Switalska H, Gaciong Z, Cupples LA, Aschengrau A, Warram JH,
Krolewski AS
. Determinants of progression from microalbuminuria to proteinuria in patients who have type 1 diabetes and are treated with angiotensin-converting enzyme inhibitors. Clin J Am Soc Nephrol. 2007 May; 2(3):461-9.
PMID:
17699452
.
Citations:
24
Fields:
Nep
Nephrology
Translation:
Humans
Keenan HA, Poznik GD, Varo N, Schneider J, Almasy L, Warram JH, Duggirala R, Schoenbeck U,
Krolewski AS
,
Doria A
. Identification of a locus modulating serum C-reactive protein levels on chromosome 5p15. Atherosclerosis. 2008 Feb; 196(2):863-70.
PMID:
17343862
.
Citations:
5
Fields:
Vas
Vascular Diseases
Translation:
Humans
Cells
Perkins BA, Ficociello LH, Ostrander BE, Silva KH, Weinberg J, Warram JH,
Krolewski AS
. Microalbuminuria and the risk for early progressive renal function decline in type 1 diabetes. J Am Soc Nephrol. 2007 Apr; 18(4):1353-61.
PMID:
17329575
.
Citations:
164
Fields:
Nep
Nephrology
Translation:
Humans
Wanic K, Malecki MT, Klupa T, Warram JH, Sieradzki J,
Krolewski AS
. Lack of association between polymorphisms in the gene encoding protein phosphatase 1B (PTPN1) and risk of type 2 diabetes. Diabetic Med. 2007; 24(6):650-5.
Placha G, Poznik GD, Dunn J, Smiles A, Krolewski B, Glew T, Puppala S, Schneider J, Rogus JJ, Rich SS, Duggirala R, Warram JH,
Krolewski AS
. A genome-wide linkage scan for genes controlling variation in renal function estimated by serum cystatin C levels in extended families with type 2 diabetes. Diabetes. 2006 Dec; 55(12):3358-65.
PMID:
17130480
.
Citations:
31
Fields:
End
Endocrinology
Translation:
Humans
Cells
Ng DP, Placha G, Choo S, Chia KS, Warram JH,
Krolewski AS
. A disease haplotype for advanced nephropathy in type 2 diabetes at the ACE locus. Diabetes. 2006 Sep; 55(9):2660-3.
PMID:
16936219
.
Citations:
12
Fields:
End
Endocrinology
Translation:
Humans
Dunn JS, Mlynarski WM, Pezzolesi MG, Borowiec M, Powers C,
Krolewski AS
,
Doria A
. Examination of PPP1R3B as a candidate gene for the type 2 diabetes and MODY loci on chromosome 8p23. Ann Hum Genet. 2006 Sep; 70(Pt 5):587-93.
PMID:
16907705
.
Citations:
14
Fields:
Gen
Genetics
Translation:
Humans
Cells
Bochenski J, Placha G, Wanic K, Malecki M, Sieradzki J, Warram JH,
Krolewski AS
. New polymorphism of ENPP1 (PC-1) is associated with increased risk of type 2 diabetes among obese individuals. Diabetes. 2006 Sep; 55(9):2626-30.
PMID:
16936213
.
Citations:
23
Fields:
End
Endocrinology
Translation:
Humans
Mueller PW, Rogus JJ, Cleary PA, Zhao Y, Smiles AM, Steffes MW, Bucksa J, Gibson TB, Cordovado SK,
Krolewski AS
, Nierras CR, Warram JH. Genetics of Kidneys in Diabetes (GoKinD) study: a genetics collection available for identifying genetic susceptibility factors for diabetic nephropathy in type 1 diabetes. J Am Soc Nephrol. 2006 Jul; 17(7):1782-90.
PMID:
16775037
.
Citations:
62
Fields:
Nep
Nephrology
Translation:
Humans
Malecki MT, Lebrun P, Pezzolesi M, Warram JH,
Krolewski AS
, Jhala US. A newly identified mutation in an IPF1 binding site of the insulin gene promoter may predispose to type 2 diabetes mellitus. Diabetologia. 2006 Aug; 49(8):1985-7.