Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Andrzej Stefan Krolewski, Ph.D., M.D.

Title
Institution
Department
Address
Phone
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Mentoring
completed student projects
The Role of Carboxypeptidase A in Conferring Susceptibility to Diabetic Nephropathy in Type I Diabetics
Summer, 06/21/99 - 08/21/99

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. DP3DK112177 (KROLEWSKI, ANDRZEJ S) Sep 20, 2016 - Aug 31, 2019
    NIH
    Search for biomarkers to measure progression of diabetic nephropathy in Type 1 diabetes; application of proteomics technologies
    Role: Principal Investigator
  2. R24DK090961 (KING, GEORGE L) Sep 30, 2010 - Aug 31, 2013
    NIH
    Protective Factors Against the Development of Microvascular Complications
    Role: Co-Principal Investigator
  3. R01DK077532 (KROLEWSKI, ANDRZEJ S) Sep 30, 2006 - Aug 31, 2010
    NIH
    Mapping Genes for End-Stage Renal Disease in Type 1 Diabetes
    Role: Principal Investigator
  4. R01DK067638 (KROLEWSKI, ANDRZEJ S) Jul 1, 2004 - Jun 30, 2010
    NIH
    The Urinary Proteome and Renal Function Loss in Diabetes
    Role: Principal Investigator
  5. R01DK058549 (KROLEWSKI, ANDRZEJ S) Sep 1, 2001 - Aug 31, 2006
    NIH
    Mapping genes for proteinuria in type II diabetes
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ihara K, Skupien J, Kobayashi H, Md Dom ZI, Wilson JM, O'Neil K, Badger HS, Bowsman LM, Satake E, Breyer MD, Duffin KL, Krolewski AS. Erratum. Profibrotic Circulating Proteins and Risk of Early Progressive Renal Decline in Patients With Type 2 Diabetes With and Without Albuminuria. Diabetes Care 2020;43:2760-2767. Diabetes Care. 2021 Feb; 44(2):631. PMID: 33334811.
    Citations: 1     Fields:    
  2. Ihara K, Skupien J, Kobayashi H, Md Dom ZI, Wilson JM, O'Neil K, Badger HS, Bowsman LM, Satake E, Breyer MD, Duffin KL, Krolewski AS. Profibrotic Circulating Proteins and Risk of Early Progressive Renal Decline in Patients With Type 2 Diabetes With and Without Albuminuria. Diabetes Care. 2020 11; 43(11):2760-2767. PMID: 32887710.
    Citations:    Fields:    
  3. Ihara K, Skupien J, Krolewski B, Md Dom ZI, O'Neil K, Satake E, Kobayashi H, Rashidi NM, Niewczas MA, Krolewski AS. A profile of multiple circulating tumor necrosis factor receptors associated with early progressive kidney decline in Type 1 Diabetes is similar to profiles in autoimmune disorders. Kidney Int. 2021 03; 99(3):725-736. PMID: 32717193.
    Citations: 1     Fields:    
  4. Salem RM, Todd JN, Sandholm N, Cole JB, Chen WM, Andrews D, Pezzolesi MG, McKeigue PM, Hiraki LT, Qiu C, Nair V, Di Liao C, Cao JJ, Valo E, Onengut-Gumuscu S, Smiles AM, McGurnaghan SJ, Haukka JK, Harjutsalo V, Brennan EP, van Zuydam N, Ahlqvist E, Doyle R, Ahluwalia TS, Lajer M, Hughes MF, Park J, Skupien J, Spiliopoulou A, Liu A, Menon R, Boustany-Kari CM, Kang HM, Nelson RG, Klein R, Klein BE, Lee KE, Gao X, Mauer M, Maestroni S, Caramori ML, de Boer IH, Miller RG, Guo J, Boright AP, Tregouet D, Gyorgy B, Snell-Bergeon JK, Maahs DM, Bull SB, Canty AJ, Palmer CNA, Stechemesser L, Paulweber B, Weitgasser R, Sokolovska J, Rovite V, Pirags V, Prakapiene E, Radzeviciene L, Verkauskiene R, Panduru NM, Groop LC, McCarthy MI, Gu HF, Möllsten A, Falhammar H, Brismar K, Martin F, Rossing P, Costacou T, Zerbini G, Marre M, Hadjadj S, McKnight AJ, Forsblom C, McKay G, Godson C, Maxwell AP, Kretzler M, Susztak K, Colhoun HM, Krolewski A, Paterson AD, Groop PH, Rich SS, Hirschhorn JN, Florez JC. Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen. J Am Soc Nephrol. 2019 10; 30(10):2000-2016. PMID: 31537649.
    Citations: 25     Fields:    Translation:HumansCells
  5. Niewczas MA, Pavkov ME, Skupien J, Smiles A, Md Dom ZI, Wilson JM, Park J, Nair V, Schlafly A, Saulnier PJ, Satake E, Simeone CA, Shah H, Qiu C, Looker HC, Fiorina P, Ware CF, Sun JK, Doria A, Kretzler M, Susztak K, Duffin KL, Nelson RG, Krolewski AS. A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes. Nat Med. 2019 05; 25(5):805-813. PMID: 31011203.
    Citations: 48     Fields:    Translation:Humans
  6. Skupien J, Smiles AM, Valo E, Ahluwalia TS, Gyorgy B, Sandholm N, Croall S, Lajer M, McDonnell K, Forsblom C, Harjutsalo V, Marre M, Galecki AT, Tregouet DA, Wu CY, Mychaleckyj JC, Nickerson H, Pragnell M, Rich SS, Pezzolesi MG, Hadjadj S, Rossing P, Groop PH, Krolewski AS. Variations in Risk of End-Stage Renal Disease and Risk of Mortality in an International Study of Patients With Type 1 Diabetes and Advanced Nephropathy. Diabetes Care. 2019 01; 42(1):93-101. PMID: 30455333.
    Citations: 5     Fields:    Translation:Humans
  7. Nabity MB, Polli JW, Vaidya V, Krolewski A, Glaab WE. New Frontiers: Approaches to Understand the Mechanistic Basis of Renal Toxicity. Toxicol Pathol. 2018 12; 46(8):1002-1005. PMID: 30189777.
    Citations:    Fields:    Translation:HumansAnimals
  8. van Zuydam NR, Ahlqvist E, Sandholm N, Deshmukh H, Rayner NW, Abdalla M, Ladenvall C, Ziemek D, Fauman E, Robertson NR, McKeigue PM, Valo E, Forsblom C, Harjutsalo V, Perna A, Rurali E, Marcovecchio ML, Igo RP, Salem RM, Perico N, Lajer M, Käräjämäki A, Imamura M, Kubo M, Takahashi A, Sim X, Liu J, van Dam RM, Jiang G, Tam CHT, Luk AOY, Lee HM, Lim CKP, Szeto CC, So WY, Chan JCN, Ang SF, Dorajoo R, Wang L, Clara TSH, McKnight AJ, Duffy S, Pezzolesi MG, Marre M, Gyorgy B, Hadjadj S, Hiraki LT, Ahluwalia TS, Almgren P, Schulz CA, Orho-Melander M, Linneberg A, Christensen C, Witte DR, Grarup N, Brandslund I, Melander O, Paterson AD, Tregouet D, Maxwell AP, Lim SC, Ma RCW, Tai ES, Maeda S, Lyssenko V, Tuomi T, Krolewski AS, Rich SS, Hirschhorn JN, Florez JC, Dunger D, Pedersen O, Hansen T, Rossing P, Remuzzi G, Brosnan MJ, Palmer CNA, Groop PH, Colhoun HM, Groop LC, McCarthy MI. A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes. Diabetes. 2018 07; 67(7):1414-1427. PMID: 29703844.
    Citations: 30     Fields:    Translation:Humans
  9. Satake E, Pezzolesi MG, Md Dom ZI, Smiles AM, Niewczas MA, Krolewski AS. Circulating miRNA Profiles Associated With Hyperglycemia in Patients With Type 1 Diabetes. Diabetes. 2018 05; 67(5):1013-1023. PMID: 29453204.
    Citations: 23     Fields:    Translation:HumansCells
  10. Nowak N, Skupien J, Smiles AM, Yamanouchi M, Niewczas MA, Galecki AT, Duffin KL, Breyer MD, Pullen N, Bonventre JV, Krolewski AS. Markers of early progressive renal decline in type 2 diabetes suggest different implications for etiological studies and prognostic tests development. Kidney Int. 2018 05; 93(5):1198-1206. PMID: 29398132.
    Citations: 25     Fields:    Translation:Humans
  11. Niewczas MA, Krolewski AS. Response to Comment on Niewczas et al. Circulating Modified Metabolites and a Risk of ESRD in Patients With Type 1 Diabetes and Chronic Kidney Disease. Diabetes Care 2017;40:383-390. Diabetes Care. 2017 08; 40(8):e109-e110. PMID: 28733381.
    Citations:    Fields:    Translation:Humans
  12. Yamanouchi M, Skupien J, Niewczas MA, Smiles AM, Doria A, Stanton RC, Galecki AT, Duffin KL, Pullen N, Breyer MD, Bonventre JV, Warram JH, Krolewski AS. Improved clinical trial enrollment criterion to identify patients with diabetes at risk of end-stage renal disease. Kidney Int. 2017 07; 92(1):258-266. PMID: 28396115.
    Citations: 15     Fields:    Translation:Humans
  13. Krolewski AS, Skupien J, Rossing P, Warram JH. Fast renal decline to end-stage renal disease: an unrecognized feature of nephropathy in diabetes. Kidney Int. 2017 06; 91(6):1300-1311. PMID: 28366227.
    Citations: 42     Fields:    Translation:Humans
  14. Niewczas MA, Mathew AV, Croall S, Byun J, Major M, Sabisetti VS, Smiles A, Bonventre JV, Pennathur S, Krolewski AS. Circulating Modified Metabolites and a Risk of ESRD in Patients With Type 1 Diabetes and Chronic Kidney Disease. Diabetes Care. 2017 Mar; 40(3):383-390. PMID: 28087576.
    Citations: 18     Fields:    Translation:Humans
  15. Sandholm N, Van Zuydam N, Ahlqvist E, Juliusdottir T, Deshmukh HA, Rayner NW, Di Camillo B, Forsblom C, Fadista J, Ziemek D, Salem RM, Hiraki LT, Pezzolesi M, Trégouët D, Dahlström E, Valo E, Oskolkov N, Ladenvall C, Marcovecchio ML, Cooper J, Sambo F, Malovini A, Manfrini M, McKnight AJ, Lajer M, Harjutsalo V, Gordin D, Parkkonen M, Tuomilehto J, Lyssenko V, McKeigue PM, Rich SS, Brosnan MJ, Fauman E, Bellazzi R, Rossing P, Hadjadj S, Krolewski A, Paterson AD, Florez JC, Hirschhorn JN, Maxwell AP, Dunger D, Cobelli C, Colhoun HM, Groop L, McCarthy MI, Groop PH. The Genetic Landscape of Renal Complications in Type 1 Diabetes. J Am Soc Nephrol. 2017 02; 28(2):557-574. PMID: 27647854.
    Citations: 31     Fields:    Translation:Humans
  16. Skupien J, Warram JH, Smiles AM, Stanton RC, Krolewski AS. Patterns of Estimated Glomerular Filtration Rate Decline Leading to End-Stage Renal Disease in Type 1 Diabetes. Diabetes Care. 2016 Dec; 39(12):2262-2269. PMID: 27647852.
    Citations: 11     Fields:    Translation:Humans
  17. Nowak N, Skupien J, Niewczas MA, Yamanouchi M, Major M, Croall S, Smiles A, Warram JH, Bonventre JV, Krolewski AS. Increased plasma kidney injury molecule-1 suggests early progressive renal decline in non-proteinuric patients with type 1 diabetes. Kidney Int. 2016 Feb; 89(2):459-67. PMID: 26509588.
    Citations: 28     Fields:    Translation:Humans
  18. Pavkov ME, Weil EJ, Fufaa GD, Nelson RG, Lemley KV, Knowler WC, Niewczas MA, Krolewski AS. Tumor necrosis factor receptors 1 and 2 are associated with early glomerular lesions in type 2 diabetes. Kidney Int. 2016 Jan; 89(1):226-34. PMID: 26398493.
    Citations: 21     Fields:    Translation:HumansCells
  19. Orlov S, Cherney DZ, Pop-Busui R, Lovblom LE, Ficociello LH, Smiles AM, Warram JH, Krolewski AS, Perkins BA. Cardiac autonomic neuropathy and early progressive renal decline in patients with nonmacroalbuminuric type 1 diabetes. Clin J Am Soc Nephrol. 2015 Jul 07; 10(7):1136-44. PMID: 26092828.
    Citations: 9     Fields:    Translation:Humans
  20. Krolewski AS. Progressive renal decline: the new paradigm of diabetic nephropathy in type 1 diabetes. Diabetes Care. 2015 Jun; 38(6):954-62. PMID: 25998286.
    Citations: 54     Fields:    Translation:Humans
  21. Pezzolesi MG, Satake E, McDonnell KP, Major M, Smiles AM, Krolewski AS. Circulating TGF-ß1-Regulated miRNAs and the Risk of Rapid Progression to ESRD in Type 1 Diabetes. Diabetes. 2015 Sep; 64(9):3285-93. PMID: 25931475.
    Citations: 28     Fields:    Translation:Humans
  22. Caramori ML, Kim Y, Goldfine AB, Moore JH, Rich SS, Mychaleckyj JC, Kirkpatrick D, Nickerson H, Krolewski AS, Mauer M. Differential Gene Expression in Diabetic Nephropathy in Individuals With Type 1 Diabetes. J Clin Endocrinol Metab. 2015 Jun; 100(6):E876-82. PMID: 25871838.
    Citations: 7     Fields:    Translation:HumansCells
  23. Pavkov ME, Nelson RG, Knowler WC, Cheng Y, Krolewski AS, Niewczas MA. Elevation of circulating TNF receptors 1 and 2 increases the risk of end-stage renal disease in American Indians with type 2 diabetes. Kidney Int. 2015 Apr; 87(4):812-9. PMID: 25272234.
    Citations: 37     Fields:    Translation:Humans
  24. Sabbisetti VS, Waikar SS, Antoine DJ, Smiles A, Wang C, Ravisankar A, Ito K, Sharma S, Ramadesikan S, Lee M, Briskin R, De Jager PL, Ngo TT, Radlinski M, Dear JW, Park KB, Betensky R, Krolewski AS, Bonventre JV. Blood kidney injury molecule-1 is a biomarker of acute and chronic kidney injury and predicts progression to ESRD in type I diabetes. J Am Soc Nephrol. 2014 Oct; 25(10):2177-86. PMID: 24904085.
    Citations: 97     Fields:    Translation:HumansAnimals
  25. Skupien J, Warram JH, Smiles A, Galecki A, Stanton RC, Krolewski AS. Improved glycemic control and risk of ESRD in patients with type 1 diabetes and proteinuria. J Am Soc Nephrol. 2014 Dec; 25(12):2916-25. PMID: 24904086.
    Citations: 14     Fields:    Translation:Humans
  26. Skupien J, Warram JH, Niewczas MA, Gohda T, Malecki M, Mychaleckyj JC, Galecki AT, Krolewski AS. Synergism between circulating tumor necrosis factor receptor 2 and HbA(1c) in determining renal decline during 5-18 years of follow-up in patients with type 1 diabetes and proteinuria. Diabetes Care. 2014 Sep; 37(9):2601-8. PMID: 24898299.
    Citations: 16     Fields:    Translation:Humans
  27. Fiorina P, Vergani A, Bassi R, Niewczas MA, Altintas MM, Pezzolesi MG, D'Addio F, Chin M, Tezza S, Ben Nasr M, Mattinzoli D, Ikehata M, Corradi D, Schumacher V, Buvall L, Yu CC, Chang JM, La Rosa S, Finzi G, Solini A, Vincenti F, Rastaldi MP, Reiser J, Krolewski AS, Mundel PH, Sayegh MH. Role of podocyte B7-1 in diabetic nephropathy. J Am Soc Nephrol. 2014 Jul; 25(7):1415-29. PMID: 24676639.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  28. Niewczas MA, Sirich TL, Mathew AV, Skupien J, Mohney RP, Warram JH, Smiles A, Huang X, Walker W, Byun J, Karoly ED, Kensicki EM, Berry GT, Bonventre JV, Pennathur S, Meyer TW, Krolewski AS. Uremic solutes and risk of end-stage renal disease in type 2 diabetes: metabolomic study. Kidney Int. 2014 May; 85(5):1214-24. PMID: 24429397.
    Citations: 60     Fields:    Translation:Humans
  29. Krolewski AS, Gohda T, Niewczas MA. Progressive renal decline as the major feature of diabetic nephropathy in type 1 diabetes. Clin Exp Nephrol. 2014 Aug; 18(4):571-83. PMID: 24218296.
    Citations: 9     Fields:    Translation:HumansAnimals
  30. Pezzolesi MG, Krolewski AS. Diabetic nephropathy: is ESRD its only heritable phenotype? J Am Soc Nephrol. 2013 Oct; 24(10):1505-7. PMID: 24029425.
    Citations: 3     Fields:    Translation:HumansCells
  31. Qi L, Qi Q, Prudente S, Mendonca C, Andreozzi F, di Pietro N, Sturma M, Novelli V, Mannino GC, Formoso G, Gervino EV, Hauser TH, Muehlschlegel JD, Niewczas MA, Krolewski AS, Biolo G, Pandolfi A, Rimm E, Sesti G, Trischitta V, Hu F, Doria A. Association between a genetic variant related to glutamic acid metabolism and coronary heart disease in individuals with type 2 diabetes. JAMA. 2013 Aug 28; 310(8):821-8. PMID: 23982368.
    Citations: 41     Fields:    Translation:HumansCells
  32. Krolewski AS, Niewczas MA, Skupien J, Gohda T, Smiles A, Eckfeldt JH, Doria A, Warram JH. Early progressive renal decline precedes the onset of microalbuminuria and its progression to macroalbuminuria. Diabetes Care. 2014; 37(1):226-34. PMID: 23939543.
    Citations: 84     Fields:    Translation:Humans
  33. Skupien J, Warram JH, Groop PH, Krolewski AS. Cystatin-based estimated GFR versus creatinine-based and creatinine- and cystatin-based estimated GFR for ESRD and mortality risk in diabetes. Am J Kidney Dis. 2013 Jul; 62(1):184-6. PMID: 23684753.
    Citations: 3     Fields:    Translation:Humans
  34. Pezzolesi MG, Jeong J, Smiles AM, Skupien J, Mychaleckyj JC, Rich SS, Warram JH, Krolewski AS. Family-based association analysis confirms the role of the chromosome 9q21.32 locus in the susceptibility of diabetic nephropathy. PLoS One. 2013; 8(3):e60301. PMID: 23555951.
    Citations: 9     Fields:    Translation:HumansCells
  35. Lee JE, Gohda T, Walker WH, Skupien J, Smiles AM, Holak RR, Jeong J, McDonnell KP, Krolewski AS, Niewczas MA. Risk of ESRD and all cause mortality in type 2 diabetes according to circulating levels of FGF-23 and TNFR1. PLoS One. 2013; 8(3):e58007. PMID: 23526964.
    Citations: 14     Fields:    Translation:Humans
  36. Wanic K, Krolewski B, Ju W, Placha G, Niewczas MA, Walker W, Warram JH, Kretzler M, Krolewski AS. Transcriptome analysis of proximal tubular cells (HK-2) exposed to urines of type 1 diabetes patients at risk of early progressive renal function decline. PLoS One. 2013; 8(3):e57751. PMID: 23505438.
    Citations: 2     Fields:    Translation:HumansCells
  37. Merchant ML, Niewczas MA, Ficociello LH, Lukenbill JA, Wilkey DW, Li M, Khundmiri SJ, Warram JH, Krolewski AS, Klein JB. Plasma kininogen and kininogen fragments are biomarkers of progressive renal decline in type 1 diabetes. Kidney Int. 2013 Jun; 83(6):1177-84. PMID: 23466993.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  38. Martini S, Nair V, Patel SR, Eichinger F, Nelson RG, Weil EJ, Pezzolesi MG, Krolewski AS, Randolph A, Keller BJ, Werner T, Kretzler M. From single nucleotide polymorphism to transcriptional mechanism: a model for FRMD3 in diabetic nephropathy. Diabetes. 2013 Jul; 62(7):2605-12. PMID: 23434934.
    Citations: 25     Fields:    Translation:HumansCells
  39. Pezzolesi MG, Krolewski AS. The genetic risk of kidney disease in type 2 diabetes. Med Clin North Am. 2013 Jan; 97(1):91-107. PMID: 23290732.
    Citations: 15     Fields:    Translation:Humans
  40. Krolewski AS, Bonventre JV. High risk of ESRD in type 1 diabetes: new strategies are needed to retard progressive renal function decline. Semin Nephrol. 2012 Sep; 32(5):407-14. PMID: 23062980.
    Citations: 15     Fields:    Translation:Humans
  41. Krolewski AS, Bonventre JV. High risk of ESRD in type 1 diabetes: call for action: introduction. Semin Nephrol. 2012 Sep; 32(5):405-6. PMID: 23062979.
    Citations: 1     Fields:    Translation:Humans
  42. Krolewski AS, Warram JH, Forsblom C, Smiles AM, Thorn L, Skupien J, Harjutsalo V, Stanton R, Eckfeldt JH, Inker LA, Groop PH. Serum concentration of cystatin C and risk of end-stage renal disease in diabetes. Diabetes Care. 2012 Nov; 35(11):2311-6. PMID: 22851596.
    Citations: 32     Fields:    Translation:Humans
  43. Skupien J, Warram JH, Smiles AM, Niewczas MA, Gohda T, Pezzolesi MG, Cantarovich D, Stanton R, Krolewski AS. The early decline in renal function in patients with type 1 diabetes and proteinuria predicts the risk of end-stage renal disease. Kidney Int. 2012 Sep; 82(5):589-97. PMID: 22622493.
    Citations: 48     Fields:    Translation:Humans
  44. Perkins BA, Rabbani N, Weston A, Ficociello LH, Adaikalakoteswari A, Niewczas M, Warram J, Krolewski AS, Thornalley P. Serum levels of advanced glycation endproducts and other markers of protein damage in early diabetic nephropathy in type 1 diabetes. PLoS One. 2012; 7(4):e35655. PMID: 22558190.
    Citations: 20     Fields:    Translation:Humans
  45. Gohda T, Walker WH, Wolkow P, Lee JE, Warram JH, Krolewski AS, Niewczas MA. Elevated urinary excretion of immunoglobulins in nonproteinuric patients with type 1 diabetes. Am J Physiol Renal Physiol. 2012 Jul 01; 303(1):F157-62. PMID: 22513848.
    Citations: 10     Fields:    Translation:Humans
  46. Niewczas MA, Gohda T, Skupien J, Smiles AM, Walker WH, Rosetti F, Cullere X, Eckfeldt JH, Doria A, Mayadas TN, Warram JH, Krolewski AS. Circulating TNF receptors 1 and 2 predict ESRD in type 2 diabetes. J Am Soc Nephrol. 2012 Mar; 23(3):507-15. PMID: 22266663.
    Citations: 169     Fields:    Translation:HumansCells
  47. Gohda T, Niewczas MA, Ficociello LH, Walker WH, Skupien J, Rosetti F, Cullere X, Johnson AC, Crabtree G, Smiles AM, Mayadas TN, Warram JH, Krolewski AS. Circulating TNF receptors 1 and 2 predict stage 3 CKD in type 1 diabetes. J Am Soc Nephrol. 2012 Mar; 23(3):516-24. PMID: 22266664.
    Citations: 137     Fields:    Translation:HumansCells
  48. Doria A, Krolewski AS. Diabetes: Lowering serum uric acid levels to prevent kidney failure. Nat Rev Nephrol. 2011 Aug 02; 7(9):495-6. PMID: 21808278.
    Citations: 6     Fields:    Translation:Humans
  49. Pezzolesi MG, Poznik GD, Skupien J, Smiles AM, Mychaleckyj JC, Rich SS, Warram JH, Krolewski AS. An intergenic region on chromosome 13q33.3 is associated with the susceptibility to kidney disease in type 1 and 2 diabetes. Kidney Int. 2011 Jul; 80(1):105-11. PMID: 21412220.
    Citations: 15     Fields:    Translation:HumansCells
  50. Rosolowsky ET, Skupien J, Smiles AM, Niewczas M, Roshan B, Stanton R, Eckfeldt JH, Warram JH, Krolewski AS. Risk for ESRD in type 1 diabetes remains high despite renoprotection. J Am Soc Nephrol. 2011 Mar; 22(3):545-53. PMID: 21355053.
    Citations: 74     Fields:    Translation:Humans
  51. Kure M, Pezzolesi MG, Poznik GD, Katavetin P, Skupien J, Dunn JS, Mychaleckyj JC, Warram JH, Krolewski AS. Genetic variation in the matrix metalloproteinase genes and diabetic nephropathy in type 1 diabetes. Mol Genet Metab. 2011 May; 103(1):60-5. PMID: 21277817.
    Citations: 6     Fields:    Translation:Humans
  52. Vaidya VS, Niewczas MA, Ficociello LH, Johnson AC, Collings FB, Warram JH, Krolewski AS, Bonventre JV. Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers, kidney injury molecule-1, and N-acetyl-ß-D-glucosaminidase. Kidney Int. 2011 Feb; 79(4):464-70. PMID: 20980978.
    Citations: 89     Fields:    Translation:Humans
  53. Good DM, Zürbig P, Argilés A, Bauer HW, Behrens G, Coon JJ, Dakna M, Decramer S, Delles C, Dominiczak AF, Ehrich JH, Eitner F, Fliser D, Frommberger M, Ganser A, Girolami MA, Golovko I, Gwinner W, Haubitz M, Herget-Rosenthal S, Jankowski J, Jahn H, Jerums G, Julian BA, Kellmann M, Kliem V, Kolch W, Krolewski AS, Luppi M, Massy Z, Melter M, Neusüss C, Novak J, Peter K, Rossing K, Rupprecht H, Schanstra JP, Schiffer E, Stolzenburg JU, Tarnow L, Theodorescu D, Thongboonkerd V, Vanholder R, Weissinger EM, Mischak H, Schmitt-Kopplin P. Naturally occurring human urinary peptides for use in diagnosis of chronic kidney disease. Mol Cell Proteomics. 2010 Nov; 9(11):2424-37. PMID: 20616184.
    Citations: 128     Fields:    Translation:Humans
  54. Liew CW, Bochenski J, Kawamori D, Hu J, Leech CA, Wanic K, Malecki M, Warram JH, Qi L, Krolewski AS, Kulkarni RN. The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells. J Clin Invest. 2010 Aug; 120(8):2876-88. PMID: 20592469.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  55. Ficociello LH, Rosolowsky ET, Niewczas MA, Maselli NJ, Weinberg JM, Aschengrau A, Eckfeldt JH, Stanton RC, Galecki AT, Doria A, Warram JH, Krolewski AS. High-normal serum uric acid increases risk of early progressive renal function loss in type 1 diabetes: results of a 6-year follow-up. Diabetes Care. 2010 Jun; 33(6):1337-43. PMID: 20332356.
    Citations: 79     Fields:    Translation:Humans
  56. Pezzolesi MG, Skupien J, Mychaleckyj JC, Warram JH, Krolewski AS. Insights to the genetics of diabetic nephropathy through a genome-wide association study of the GoKinD collection. Semin Nephrol. 2010 Mar; 30(2):126-40. PMID: 20347642.
    Citations: 11     Fields:    Translation:HumansAnimals
  57. Perkins BA, Ficociello LH, Roshan B, Warram JH, Krolewski AS. In patients with type 1 diabetes and new-onset microalbuminuria the development of advanced chronic kidney disease may not require progression to proteinuria. Kidney Int. 2010 Jan; 77(1):57-64. PMID: 19847154.
    Citations: 93     Fields:    Translation:Humans
  58. Tsaih SW, Pezzolesi MG, Yuan R, Warram JH, Krolewski AS, Korstanje R. Genetic analysis of albuminuria in aging mice and concordance with loci for human diabetic nephropathy found in a genome-wide association scan. Kidney Int. 2010 Feb; 77(3):201-10. PMID: 19924099.
    Citations: 21     Fields:    Translation:HumansAnimals
  59. Borowiec M, Liew CW, Thompson R, Boonyasrisawat W, Hu J, Mlynarski WM, El Khattabi I, Kim SH, Marselli L, Rich SS, Krolewski AS, Bonner-Weir S, Sharma A, Sale M, Mychaleckyj JC, Kulkarni RN, Doria A. Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14460-5. PMID: 19667185.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  60. Pezzolesi MG, Katavetin P, Kure M, Poznik GD, Skupien J, Mychaleckyj JC, Rich SS, Warram JH, Krolewski AS. Confirmation of genetic associations at ELMO1 in the GoKinD collection supports its role as a susceptibility gene in diabetic nephropathy. Diabetes. 2009 Nov; 58(11):2698-702. PMID: 19651817.
    Citations: 58     Fields:    Translation:Humans
  61. Merchant ML, Perkins BA, Boratyn GM, Ficociello LH, Wilkey DW, Barati MT, Bertram CC, Page GP, Rovin BH, Warram JH, Krolewski AS, Klein JB. Urinary peptidome may predict renal function decline in type 1 diabetes and microalbuminuria. J Am Soc Nephrol. 2009 Sep; 20(9):2065-74. PMID: 19643930.
    Citations: 53     Fields:    Translation:HumansCells
  62. Perkins BA, Aiello LP, Krolewski AS. Diabetes complications and the renin-angiotensin system. N Engl J Med. 2009 Jul 02; 361(1):83-5. PMID: 19571288.
    Citations: 8     Fields:    Translation:Humans
  63. Perkins BA, Krolewski AS. Early nephropathy in type 1 diabetes: the importance of early renal function decline. Curr Opin Nephrol Hypertens. 2009 May; 18(3):233-40. PMID: 19300247.
    Citations: 16     Fields:    Translation:Humans
  64. Pezzolesi MG, Poznik GD, Mychaleckyj JC, Paterson AD, Barati MT, Klein JB, Ng DP, Placha G, Canani LH, Bochenski J, Waggott D, Merchant ML, Krolewski B, Mirea L, Wanic K, Katavetin P, Kure M, Wolkow P, Dunn JS, Smiles A, Walker WH, Boright AP, Bull SB, Doria A, Rogus JJ, Rich SS, Warram JH, Krolewski AS. Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes. Diabetes. 2009 Jun; 58(6):1403-10. PMID: 19252134.
    Citations: 128     Fields:    Translation:Humans
  65. Ficociello LH, Perkins BA, Roshan B, Weinberg JM, Aschengrau A, Warram JH, Krolewski AS. Renal hyperfiltration and the development of microalbuminuria in type 1 diabetes. Diabetes Care. 2009 May; 32(5):889-93. PMID: 19196883.
    Citations: 31     Fields:    Translation:Humans
  66. Tsaih S, Pezzolesi MG, Yuan R, Warram JH, Krolewski AS, Korstanje R. Genetic analysis of albuminuria in the aging mouse and concordance with loci for diabetic nephropathy found in a genome-wide association scan. J Am Soc Neph. 2009; Submitted.
  67. Ficociello LH, Rosolowsky ET, Niewczas M, Maselli NJ, Roshan B, Weinberg JM, Aschengrau A, Stanton RC, Doria D, Warram JH, Krolewski AS. Serum Uric Acid and Early Renal Function Decline in Patients with Type 1 Diabetes and Microalbuminuria. Kidney Int. 2009; (accepted for publication).
  68. Merchant ML, Perkins BA, Boratyn GM, Ficociello LH, Wilkey DW, Barati MT, Bertram CC, Page GP, Rovin BH, Warram JH, Krolewski AS (senior author), Klein JB. Urinary petidome analysis and early renal function decline in type 1 diabetics with microalbuminuria. J Am Soc Nephrol. 2009; (accepted for publication).
  69. Niewczas MA, Ficociello LH, Johnson AC, Walker W, Rosolowsky ET, Roshan B, Warram JH, Krolewski AS. Serum concentrations of markers of TNFalpha and Fas-mediated pathways and renal function in nonproteinuric patients with type 1 diabetes. Clin J Am Soc Nephrol. 2009 Jan; 4(1):62-70. PMID: 19073786.
    Citations: 61     Fields:    Translation:HumansCells
  70. Rosolowsky ET, Niewczas MA, Ficociello LH, Perkins BA, Warram JH, Krolewski AS. Between hyperfiltration and impairment: demystifying early renal functional changes in diabetic nephropathy. Diabetes Res Clin Pract. 2008 Nov 13; 82 Suppl 1:S46-53. PMID: 18849087.
    Citations: 14     Fields:    Translation:Humans
  71. Wanic K, Placha G, Dunn J, Smiles A, Warram JH, Krolewski AS. Exclusion of polymorphisms in carnosinase genes (CNDP1 and CNDP2) as a cause of diabetic nephropathy in type 1 diabetes: results of large case-control and follow-up studies. Diabetes. 2008 Sep; 57(9):2547-51. PMID: 18753673.
    Citations: 23     Fields:    Translation:HumansCells
  72. Rogus JJ, Poznik GD, Pezzolesi MG, Smiles AM, Dunn J, Walker W, Wanic K, Moczulski D, Canani L, Araki S, Makita Y, Warram JH, Krolewski AS. High-density single nucleotide polymorphism genome-wide linkage scan for susceptibility genes for diabetic nephropathy in type 1 diabetes: discordant sibpair approach. Diabetes. 2008 Sep; 57(9):2519-26. PMID: 18559660.
    Citations: 19     Fields:    Translation:HumansCells
  73. Ng DP, Nurbaya S, Ye SH, Krolewski AS. An IL-6 haplotype on human chromosome 7p21 confers risk for impaired renal function in type 2 diabetic patients. Kidney Int. 2008 Aug; 74(4):521-7. PMID: 18496509.
    Citations: 12     Fields:    Translation:HumansCells
  74. Rosolowsky ET, Ficociello LH, Maselli NJ, Niewczas MA, Binns AL, Roshan B, Warram JH, Krolewski AS. High-normal serum uric acid is associated with impaired glomerular filtration rate in nonproteinuric patients with type 1 diabetes. Clin J Am Soc Nephrol. 2008 May; 3(3):706-13. PMID: 18272826.
    Citations: 54     Fields:    Translation:HumansCells
  75. Ng DP, Nurbaya S, Choo S, Koh D, Chia KS, Krolewski AS. Genetic variation at the SLC12A3 locus is unlikely to explain risk for advanced diabetic nephropathy in Caucasians with type 2 diabetes. Nephrol Dial Transplant. 2008 Jul; 23(7):2260-4. PMID: 18263927.
    Citations: 6     Fields:    Translation:Humans
  76. Wolkow PP, Niewczas MA, Perkins B, Ficociello LH, Lipinski B, Warram JH, Krolewski AS. Association of urinary inflammatory markers and renal decline in microalbuminuric type 1 diabetics. J Am Soc Nephrol. 2008 Apr; 19(4):789-97. PMID: 18256362.
    Citations: 62     Fields:    Translation:Humans
  77. Wanic K, Malecki MT, Klupa T, Warram JH, Sieradzki J, Krolewski AS. Lack of association between polymorphisms in the gene encoding protein tyrosine phosphatase 1B (PTPN1) and risk of Type 2 diabetes. Diabet Med. 2007 Jun; 24(6):650-5. PMID: 17403124.
    Citations: 2     Fields:    Translation:Humans
  78. Ficociello LH, Perkins BA, Silva KH, Finkelstein DM, Ignatowska-Switalska H, Gaciong Z, Cupples LA, Aschengrau A, Warram JH, Krolewski AS. Determinants of progression from microalbuminuria to proteinuria in patients who have type 1 diabetes and are treated with angiotensin-converting enzyme inhibitors. Clin J Am Soc Nephrol. 2007 May; 2(3):461-9. PMID: 17699452.
    Citations: 23     Fields:    Translation:Humans
  79. Keenan HA, Poznik GD, Varo N, Schneider J, Almasy L, Warram JH, Duggirala R, Schoenbeck U, Krolewski AS, Doria A. Identification of a locus modulating serum C-reactive protein levels on chromosome 5p15. Atherosclerosis. 2008 Feb; 196(2):863-70. PMID: 17343862.
    Citations: 5     Fields:    Translation:HumansCells
  80. Perkins BA, Ficociello LH, Ostrander BE, Silva KH, Weinberg J, Warram JH, Krolewski AS. Microalbuminuria and the risk for early progressive renal function decline in type 1 diabetes. J Am Soc Nephrol. 2007 Apr; 18(4):1353-61. PMID: 17329575.
    Citations: 147     Fields:    Translation:Humans
  81. Wanic K, Malecki MT, Klupa T, Warram JH, Sieradzki J, Krolewski AS. Lack of association between polymorphisms in the gene encoding protein phosphatase 1B (PTPN1) and risk of type 2 diabetes. Diabetic Med. 2007; 24(6):650-5.
  82. Placha G, Poznik GD, Dunn J, Smiles A, Krolewski B, Glew T, Puppala S, Schneider J, Rogus JJ, Rich SS, Duggirala R, Warram JH, Krolewski AS. A genome-wide linkage scan for genes controlling variation in renal function estimated by serum cystatin C levels in extended families with type 2 diabetes. Diabetes. 2006 Dec; 55(12):3358-65. PMID: 17130480.
    Citations: 30     Fields:    Translation:HumansCells
  83. Ng DP, Placha G, Choo S, Chia KS, Warram JH, Krolewski AS. A disease haplotype for advanced nephropathy in type 2 diabetes at the ACE locus. Diabetes. 2006 Sep; 55(9):2660-3. PMID: 16936219.
    Citations: 12     Fields:    Translation:Humans
  84. Dunn JS, Mlynarski WM, Pezzolesi MG, Borowiec M, Powers C, Krolewski AS, Doria A. Examination of PPP1R3B as a candidate gene for the type 2 diabetes and MODY loci on chromosome 8p23. Ann Hum Genet. 2006 Sep; 70(Pt 5):587-93. PMID: 16907705.
    Citations: 12     Fields:    Translation:HumansCells
  85. Bochenski J, Placha G, Wanic K, Malecki M, Sieradzki J, Warram JH, Krolewski AS. New polymorphism of ENPP1 (PC-1) is associated with increased risk of type 2 diabetes among obese individuals. Diabetes. 2006 Sep; 55(9):2626-30. PMID: 16936213.
    Citations: 22     Fields:    Translation:Humans
  86. Mueller PW, Rogus JJ, Cleary PA, Zhao Y, Smiles AM, Steffes MW, Bucksa J, Gibson TB, Cordovado SK, Krolewski AS, Nierras CR, Warram JH. Genetics of Kidneys in Diabetes (GoKinD) study: a genetics collection available for identifying genetic susceptibility factors for diabetic nephropathy in type 1 diabetes. J Am Soc Nephrol. 2006 Jul; 17(7):1782-90. PMID: 16775037.
    Citations: 58     Fields:    Translation:Humans
  87. Malecki MT, Lebrun P, Pezzolesi M, Warram JH, Krolewski AS, Jhala US. A newly identified mutation in an IPF1 binding site of the insulin gene promoter may predispose to type 2 diabetes mellitus. Diabetologia. 2006 Aug; 49(8):1985-7. PMID: 16741735.
    Citations: 1     Fields:    Translation:HumansCells
  88. Wanic K, Malecki MT, Wolkow PP, Klupa T, Skupien J, Bobrek J, Kozek E, Krolewski AS, Sieradzki J. Polymorphisms in the gene encoding hepatocyte nuclear factor-4alpha and susceptibility to type 2 diabetes in a Polish population. Diabetes Metab. 2006 Feb; 32(1):86-8. PMID: 16523192.
    Citations: 4     Fields:    Translation:Humans
  89. Placha G, Krolewski AS. Genetic determinants of diabetic nephropathy in type 2 diabetes. The diabetic kidney. Cortes P and Mogensen CE eds). 2006; 329-50.
  90. Mueller PM, Rogus JJ, Cleary PA, Zhao Y, Smiles AM, Steffes MW, Bucksa J, Gibson TB, Cordovado SK, Krolewski AS, Nierras CR, Warram JH. The Genetics of Kidneys in Diabetes (GoKinD) Study: A genetics collection available for identifying the genetic susceptibility factors for diabetic nephropathy in type 1 diabetes mellitus. J Am Soc Neph. 2006; 17(7):1782-90.
  91. Krolewski AS, Poznik GD, Placha G, Canani L, Dunn J, Walker W, Smiles A, Krolewski B, Fogarty DG, Moczulski D, Araki S, Makita Y, Ng DP, Rogus J, Duggirala R, Rich SS, Warram JH. A genome-wide linkage scan for genes controlling variation in urinary albumin excretion in type II diabetes. Kidney Int. 2006 Jan; 69(1):129-36. PMID: 16374433.
    Citations: 38     Fields:    Translation:Humans
  92. Poznik GD, Adamska K, Xu X, Krolewski AS, Rogus JJ. A novel framework for sib pair linkage analysis. Am J Hum Genet. 2006 Feb; 78(2):222-30. PMID: 16358216.
    Citations: 4     Fields:    Translation:Humans
  93. Perkins BA, Krolewski AS. Early nephropathy in type 1 diabetes: a new perspective on who will and who will not progress. Curr Diab Rep. 2005 Dec; 5(6):455-63. PMID: 16316598.
    Citations: 16     Fields:    Translation:Humans
  94. Mlynarski WM, Placha GP, Wolkow PP, Bochenski JP, Warram JH, Krolewski AS. Risk of diabetic nephropathy in type 1 diabetes is associated with functional polymorphisms in RANTES receptor gene (CCR5): a sex-specific effect. Diabetes. 2005 Nov; 54(11):3331-5. PMID: 16249462.
    Citations: 18     Fields:    Translation:Humans
  95. Canani LH, Capp C, Ng DP, Choo SG, Maia AL, Nabinger GB, Santos K, Crispim D, Roisemberg I, Krolewski AS, Gross JL. The fatty acid-binding protein-2 A54T polymorphism is associated with renal disease in patients with type 2 diabetes. Diabetes. 2005 Nov; 54(11):3326-30. PMID: 16249461.
    Citations: 11     Fields:    Translation:Humans
  96. Perkins BA, Nelson RG, Krolewski AS. Cystatin C and the risk of death. N Engl J Med. 2005 Aug 25; 353(8):842-4; author reply 842-4. PMID: 16124125.
    Citations: 6     Fields:    Translation:Humans
  97. Ng DP, Krolewski AS. Molecular genetic approaches for studying the etiology of diabetic nephropathy. Curr Mol Med. 2005 Aug; 5(5):509-25. PMID: 16101480.
    Citations: 16     Fields:    Translation:HumansAnimals
  98. Jones CA, Krolewski AS, Rogus J, Xue JL, Collins A, Warram JH. Epidemic of end-stage renal disease in people with diabetes in the United States population: do we know the cause? Kidney Int. 2005 May; 67(5):1684-91. PMID: 15840014.
    Citations: 50     Fields:    Translation:HumansPHPublic Health
  99. Placha G, Canani LH, Warram JH, Krolewski AS. Evidence for different susceptibility genes for proteinuria and ESRD in type 2 diabetes. Adv Chronic Kidney Dis. 2005 Apr; 12(2):155-69. PMID: 15822051.
    Citations: 30     Fields:    Translation:Humans
  100. Perkins BA, Nelson RG, Ostrander BE, Blouch KL, Krolewski AS, Myers BD, Warram JH. Detection of renal function decline in patients with diabetes and normal or elevated GFR by serial measurements of serum cystatin C concentration: results of a 4-year follow-up study. J Am Soc Nephrol. 2005 May; 16(5):1404-12. PMID: 15788478.
    Citations: 108     Fields:    Translation:Humans
  101. Warram JH, Krolewski AS. Epidemiology of diabetes mellitus. Joslin's Diabetes Mellitus. Kahn CR, Weir G, King GL, Jacobson AM, Moses AC, Smith RJ (eds.). 2005; 341-354.
  102. Krolewski AS, Warram JH. Epidemiology of late complications of diabetes. Basis for the development and evaluation of preventive programs. Joslin's Diabetes Mellitus. Kahn CR, Weir G, King GL, Jacobson AM, Moses AC, Smith RJ (eds.). 2005; 795-808.
  103. Kim SH, Ma X, Weremowicz S, Ercolino T, Powers C, Mlynarski W, Bashan KA, Warram JH, Mychaleckyj J, Rich SS, Krolewski AS, Doria A. Identification of a locus for maturity-onset diabetes of the young on chromosome 8p23. Diabetes. 2004 May; 53(5):1375-84. PMID: 15111509.
    Citations: 12     Fields:    Translation:HumansCells
  104. Ng DP, Walker WH, Chia KS, Choo S, Warram JH, Krolewski AS. Scrutiny of the glutamine-fructose-6-phosphate transaminase 1 (GFPT1) locus reveals conserved haplotype block structure not associated with diabetic nephropathy. Diabetes. 2004 Mar; 53(3):865-9. PMID: 14988277.
    Citations: 1     Fields:    Translation:HumansCells
  105. Pezzolesi MG, Nam M, Nagase T, Klupa T, Dunn JS, Mlynarski WM, Rich SS, Warram JH, Krolewski AS. Examination of candidate chromosomal regions for type 2 diabetes reveals a susceptibility locus on human chromosome 8p23.1. Diabetes. 2004 Feb; 53(2):486-91. PMID: 14747302.
    Citations: