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Charles R.G. Guttmann, M.D.

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Biography
University of Zurich, Zurich, SwitzerlandMD01/1990Medicine

Overview
Dr. Charles R. G. Guttmann is an Associate Professor of Radiology at Harvard Medical School, and the Director of the Center for Neurological Imaging, a multi-disciplinary laboratory at Brigham and Women’s Hospital, combining biomedical and computer scientists/biomedical engineers. His research interests focus on the understanding, modeling, and monitoring of neurological diseases, such as multiple sclerosis (MS) and small vessel disease in aging, by integrating imaging-derived biomarkers with clinical, genetic, immunological, and other biomarkers. To this end his laboratory has developed a large scale repository and image analysis workflow management system that has been in use for close to 20 years, and has been populated with images, image-derived metrics, a variety of genetic and blood biomarkers, as well as clinical information inserted at the time of clinical visits. To date the data repository includes over 25,000 magnetic resonance imaging (MRI) exams and data from over 45,000 clinical visits over the past in 8,556 MS patients. This system has enabled multiple large-scale, cross-disciplinary studies addressing a variety of scientific questions, such as genetic determinants of brain atrophy in MS, association studies between risk factors such as smoking and the progression of disease in MS, as well as prospective longitudinal studies to understand the clinical evolution and pathogenesis of MS, as well as to generate predictive models for use in clinical disease management. His current work includes identifying MRI correlates of fatigue and predictors of response to fatigue management interventions. Other projects in Dr. Guttmann's laboratory include studies on the role of perivascular spaces in sleep, sleep deprivation Alzheimer's Disease, and other neurological conditions; lesion-symptom mapping for image-guided focused ultrasound treatment of essential tremor. Dr. Guttmann is also leading the development of SPINE, a web-based virtual laboratory for collaborative scientific research and education. SPINE integrates data federation, image analysis workflows (automated and interactive), as well as statistical modeling. A differentiating aspect of SPINE is the tight interaction between scientific experimentation on one side, and education and image analysis standardization on the other. This approach includes web-based “club-sourcing” of domain experts and ‘crowdsourcing’ of less educated scientific contributors that can be certified in focused analytical tasks, such as outlining an anatomical structure on a CT or MRI image stack.

Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Vrenken H, Jenkinson M, Pham D, Guttmann CRG, Pareto D, Paardekooper M, de Sitter A, Rocca MA, Wottschel V, Cardoso MJ, Barkhof F. Opportunities for Understanding MS Mechanisms and Progression With MRI Using Large-Scale Data Sharing and Artificial Intelligence. Neurology. 2021 Oct 04. PMID: 34607924.
    Citations:    Fields:    
  2. Eshaghi A, Young AL, Wijeratne PA, Prados F, Arnold DL, Narayanan S, Guttmann CRG, Barkhof F, Alexander DC, Thompson AJ, Chard D, Ciccarelli O. Author Correction: Identifying multiple sclerosis subtypes using unsupervised machine learning and MRI data. Nat Commun. 2021 May 20; 12(1):3169. PMID: 34016975.
    Citations:    Fields:    
  3. Schregel K, Baufeld C, Palotai M, Meroni R, Fiorina P, Wuerfel J, Sinkus R, Zhang YZ, McDannold N, White PJ, Guttmann CRG. Targeted Blood Brain Barrier Opening With Focused Ultrasound Induces Focal Macrophage/Microglial Activation in Experimental Autoimmune Encephalomyelitis. Front Neurosci. 2021; 15:665722. PMID: 34054415.
    Citations:    
  4. Palotai M, Wallack M, Kujbus G, Dalnoki A, Guttmann C. Usability of a Mobile App for Real-Time Assessment of Fatigue and Related Symptoms in Patients With Multiple Sclerosis: Observational Study. JMIR Mhealth Uhealth. 2021 04 16; 9(4):e19564. PMID: 33861208.
    Citations: 2     Fields:    Translation:Humans
  5. de Sitter A, Burggraaff J, Bartel F, Palotai M, Liu Y, Simoes J, Ruggieri S, Schregel K, Ropele S, Rocca MA, Gasperini C, Gallo A, Schoonheim MM, Amann M, Yiannakas M, Pareto D, Wattjes MP, Sastre-Garriga J, Kappos L, Filippi M, Enzinger C, Frederiksen J, Uitdehaag B, Guttmann CRG, Barkhof F, Vrenken H. Development and evaluation of a manual segmentation protocol for deep grey matter in multiple sclerosis: Towards accelerated semi-automated references. Neuroimage Clin. 2021; 30:102659. PMID: 33882422.
    Citations:    Fields:    Translation:Humans
  6. Eshaghi A, Young AL, Wijeratne PA, Prados F, Arnold DL, Narayanan S, Guttmann CRG, Barkhof F, Alexander DC, Thompson AJ, Chard D, Ciccarelli O. Identifying multiple sclerosis subtypes using unsupervised machine learning and MRI data. Nat Commun. 2021 04 06; 12(1):2078. PMID: 33824310.
    Citations: 3     Fields:    Translation:Humans
  7. Palotai M, Small C, Makris N, Somes NG, Pinzon AM, Rathi Y, Marzullo A, Levitt JJ, Bakshi R, Chitnis T, Guttmann CRG. Microstructural Changes in the Left Mesocorticolimbic Pathway are Associated with the Comorbid Development of Fatigue and Depression in Multiple Sclerosis. J Neuroimaging. 2021 05; 31(3):501-507. PMID: 33522683.
    Citations: 1     Fields:    Translation:Humans
  8. Rosso M, Healy BC, Saxena S, Paul A, Bjornevik K, Kuhle J, Benkert P, Leppert D, Guttmann C, Bakshi R, Weiner HL, Chitnis T. MRI Lesion State Modulates the Relationship Between Serum Neurofilament Light and Age in Multiple Sclerosis. J Neuroimaging. 2021 03; 31(2):388-393. PMID: 33476489.
    Citations:    Fields:    Translation:Humans
  9. Burggraaff J, Liu Y, Prieto JC, Simoes J, de Sitter A, Ruggieri S, Brouwer I, Lissenberg-Witte BI, Rocca MA, Valsasina P, Ropele S, Gasperini C, Gallo A, Pareto D, Sastre-Garriga J, Enzinger C, Filippi M, De Stefano N, Ciccarelli O, Hulst HE, Wattjes MP, Barkhof F, Uitdehaag BMJ, Vrenken H, Guttmann CRG. Manual and automated tissue segmentation confirm the impact of thalamus atrophy on cognition in multiple sclerosis: A multicenter study. Neuroimage Clin. 2021; 29:102549. PMID: 33401136.
    Citations: 3     Fields:    Translation:Humans
  10. Deol M, Palotai M, Pinzon AM, Marciniak A, Bliault G, Covert E, Aizer A, Guenette JP, Desalvo MN, Li XT, Thomas A, Tran NA, Jacobson A, Huang R, Guttmann CRG. Identification and Characterization of Leptomeningeal Metastases Using SPINE, A Web-Based Collaborative Platform. J Neuroimaging. 2021 03; 31(2):324-333. PMID: 33332686.
    Citations:    Fields:    Translation:Humans
  11. Troili F, Cipollini V, Moci M, Morena E, Palotai M, Rinaldi V, Romano C, Ristori G, Giubilei F, Salvetti M, Orzi F, Guttmann CRG, Cavallari M. Corrigendum: Perivascular Unit: This Must Be the Place. The Anatomical Crossroad Between the Immune, Vascular and Nervous System. Front Neuroanat. 2020; 14:51. PMID: 33041773.
    Citations:    
  12. de Sitter A, Verhoeven T, Burggraaff J, Liu Y, Simoes J, Ruggieri S, Palotai M, Brouwer I, Versteeg A, Wottschel V, Ropele S, Rocca MA, Gasperini C, Gallo A, Yiannakas MC, Rovira A, Enzinger C, Filippi M, De Stefano N, Kappos L, Frederiksen JL, Uitdehaag BMJ, Barkhof F, Guttmann CRG, Vrenken H. Reduced accuracy of MRI deep grey matter segmentation in multiple sclerosis: an evaluation of four automated methods against manual reference segmentations in a multi-center cohort. J Neurol. 2020 Dec; 267(12):3541-3554. PMID: 32621103.
    Citations: 1     Fields:    Translation:Humans
  13. Meier IB, Lao PJ, Gietl A, Vorburger RS, Gutierrez J, Holland CM, Guttmann CRG, Meier DS, Buck A, Nitsch RM, Hock C, Unschuld PG, Brickman AM. Brain areas with normatively greater cerebral perfusion in early life may be more susceptible to beta amyloid deposition in late life. Cereb Circ Cogn Behav. 2020; 1. PMID: 34368788.
    Citations:    
  14. Rosso M, Gonzalez CT, Healy BC, Saxena S, Paul A, Bjornevik K, Kuhle J, Benkert P, Leppert D, Guttmann C, Bakshi R, Weiner HL, Chitnis T. Temporal association of sNfL and gad-enhancing lesions in multiple sclerosis. Ann Clin Transl Neurol. 2020 06; 7(6):945-955. PMID: 32452160.
    Citations: 5     Fields:    Translation:Humans
  15. Troili F, Cipollini V, Moci M, Morena E, Palotai M, Rinaldi V, Romano C, Ristori G, Giubilei F, Salvetti M, Orzi F, Guttmann CRG, Cavallari M. Perivascular Unit: This Must Be the Place. The Anatomical Crossroad Between the Immune, Vascular and Nervous System. Front Neuroanat. 2020; 14:17. PMID: 32372921.
    Citations: 5     
  16. Brisset JC, Kremer S, Hannoun S, Bonneville F, Durand-Dubief F, Tourdias T, Barillot C, Guttmann C, Vukusic S, Dousset V, Cotton F. New OFSEP recommendations for MRI assessment of multiple sclerosis patients: Special consideration for gadolinium deposition and frequent acquisitions. J Neuroradiol. 2020 Jun; 47(4):250-258. PMID: 32014494.
    Citations: 1     Fields:    Translation:Humans
  17. Palotai M, Cavallari M, Healy BC, Guttmann CR. A novel classification of fatigue in multiple sclerosis based on longitudinal assessments. Mult Scler. 2020 05; 26(6):725-734. PMID: 31971067.
    Citations: 2     Fields:    Translation:Humans
  18. de Sitter A, Visser M, Brouwer I, Cover KS, van Schijndel RA, Eijgelaar RS, Müller DMJ, Ropele S, Kappos L, Rovira Á, Filippi M, Enzinger C, Frederiksen J, Ciccarelli O, Guttmann CRG, Wattjes MP, Witte MG, de Witt Hamer PC, Barkhof F, Vrenken H. Facing privacy in neuroimaging: removing facial features degrades performance of image analysis methods. Eur Radiol. 2020 Feb; 30(2):1062-1074. PMID: 31691120.
    Citations: 5     Fields:    Translation:Humans
  19. White WB, Wakefield DB, Moscufo N, Guttmann CRG, Kaplan RF, Bohannon RW, Fellows D, Hall CB, Wolfson L. Effects of Intensive Versus Standard Ambulatory Blood Pressure Control on Cerebrovascular Outcomes in Older People (INFINITY). Circulation. 2019 11 12; 140(20):1626-1635. PMID: 31607143.
    Citations: 17     Fields:    Translation:Humans
  20. Palotai M, Nazeri A, Cavallari M, Healy BC, Glanz B, Gold SM, Weiner HL, Chitnis T, Guttmann CRG. History of fatigue in multiple sclerosis is associated with grey matter atrophy. Sci Rep. 2019 10 14; 9(1):14781. PMID: 31611598.
    Citations: 5     Fields:    Translation:Humans
  21. Palotai M, Guttmann CR. Brain anatomical correlates of fatigue in multiple sclerosis. Mult Scler. 2020 06; 26(7):751-764. PMID: 31536461.
    Citations: 2     Fields:    Translation:Humans
  22. Daiello LA, Racine AM, Yun Gou R, Marcantonio ER, Xie Z, Kunze LJ, Vlassakov KV, Inouye SK, Jones RN, Alsop D, Travison T, Arnold S, Cooper Z, Dickerson B, Fong T, Metzger E, Pascual-Leone A, Schmitt EM, Shafi M, Cavallari M, Dai W, Dillon ST, McElhaney J, Guttmann C, Hshieh T, Kuchel G, Libermann T, Ngo L, Press D, Saczynski J, Vasunilashorn S, O'Connor M, Kimchi E, Strauss J, Wong B, Belkin M, Ayres D, Callery M, Pomposelli F, Wright J, Schermerhorn M, Abrantes T, Albuquerque A, Bertrand S, Brown A, Callahan A, D'Aquila M, Dowal S, Fox M, Gallagher J, Anna Gersten R, Hodara A, Helfand B, Inloes J, Kettell J, Kuczmarska A, Nee J, Nemeth E, Ochsner L, Palihnich K, Parisi K, Puelle M, Rastegar S, Vella M, Xu G, Bryan M, Guess J, Enghorn D, Gross A, Gou Y, Habtemariam D, Isaza I, Kosar C, Rockett C, Tommet D, Gruen T, Ross M, Tasker K, Gee J, Kolanowski A, Pisani M, de Rooij S, Rogers S, Studenski S, Stern Y, Whittemore A, Gottlieb G, Orav J, Sperling R. Postoperative Delirium and Postoperative Cognitive Dysfunction: Overlap and Divergence. Anesthesiology. 2019 09; 131(3):477-491. PMID: 31166241.
    Citations: 27     Fields:    Translation:Humans
  23. Palotai M, Cavallari M, Koubiyr I, Morales Pinzon A, Nazeri A, Healy BC, Glanz B, Weiner HL, Chitnis T, Guttmann CR. Microstructural fronto-striatal and temporo-insular alterations are associated with fatigue in patients with multiple sclerosis independent of white matter lesion load and depression. Mult Scler. 2020 11; 26(13):1708-1718. PMID: 31418637.
    Citations: 4     Fields:    Translation:Humans
  24. Ameli R, Guttmann CRG, Prieto JC, Rollot F, Palotai M, Vukusic S, Marignier R, Cotton F. Aquaporin 4 distribution in the brain and its relevance for the radiological appearance of neuromyelitis optica spectrum disease. J Neuroradiol. 2021 May; 48(3):170-175. PMID: 30981824.
    Citations: 1     Fields:    
  25. Hannoun S, Kocevar G, Durand-Dubief F, Stamile C, Naji A, Cotton F, Cavallari M, Guttmann CRG, Sappey-Marinier D. Evidence of axonal damage in cerebellar peduncles without T2-lesions in multiple sclerosis. Eur J Radiol. 2018 Nov; 108:114-119. PMID: 30396642.
    Citations: 1     Fields:    Translation:HumansCells
  26. Commowick O, Istace A, Kain M, Laurent B, Leray F, Simon M, Pop SC, Girard P, Améli R, Ferré JC, Kerbrat A, Tourdias T, Cervenansky F, Glatard T, Beaumont J, Doyle S, Forbes F, Knight J, Khademi A, Mahbod A, Wang C, McKinley R, Wagner F, Muschelli J, Sweeney E, Roura E, Lladó X, Santos MM, Santos WP, Silva-Filho AG, Tomas-Fernandez X, Urien H, Bloch I, Valverde S, Cabezas M, Vera-Olmos FJ, Malpica N, Guttmann C, Vukusic S, Edan G, Dojat M, Styner M, Warfield SK, Cotton F, Barillot C. Objective Evaluation of Multiple Sclerosis Lesion Segmentation using a Data Management and Processing Infrastructure. Sci Rep. 2018 09 12; 8(1):13650. PMID: 30209345.
    Citations: 21     Fields:    Translation:Humans
  27. White WB, Jalil F, Wakefield DB, Kaplan RF, Bohannon RW, Hall CB, Moscufo N, Fellows D, Guttmann CRG, Wolfson L. Relationships among clinic, home, and ambulatory blood pressures with small vessel disease of the brain and functional status in older people with hypertension. Am Heart J. 2018 11; 205:21-30. PMID: 30145340.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  28. Glatard T, Kiar G, Aumentado-Armstrong T, Beck N, Bellec P, Bernard R, Bonnet A, Brown ST, Camarasu-Pop S, Cervenansky F, Das S, Ferreira da Silva R, Flandin G, Girard P, Gorgolewski KJ, Guttmann CRG, Hayot-Sasson V, Quirion PO, Rioux P, Rousseau MÉ, Evans AC. Boutiques: a flexible framework to integrate command-line applications in computing platforms. Gigascience. 2018 05 01; 7(5). PMID: 29718199.
    Citations: 8     Fields:    Translation:Humans
  29. Moscufo N, Wakefield DB, Meier DS, Cavallari M, Guttmann CRG, White WB, Wolfson L. Longitudinal microstructural changes of cerebral white matter and their association with mobility performance in older persons. PLoS One. 2018; 13(3):e0194051. PMID: 29554115.
    Citations: 7     Fields:    Translation:Humans
  30. Hannoun S, Heidelberg D, Hourani R, Nguyen TTT, Brisset JC, Grand S, Kremer S, Bonneville F, Guttmann CRG, Dousset V, Cotton F. Diagnostic value of 3DFLAIR in clinical practice for the detection of infratentorial lesions in multiple sclerosis in regard to dual echo T2 sequences. Eur J Radiol. 2018 May; 102:146-151. PMID: 29685528.
    Citations: 1     Fields:    Translation:Humans
  31. Meier DS, Guttmann CRG, Tummala S, Moscufo N, Cavallari M, Tauhid S, Bakshi R, Weiner HL. Dual-Sensitivity Multiple Sclerosis Lesion and CSF Segmentation for Multichannel 3T Brain MRI. J Neuroimaging. 2018 01; 28(1):36-47. PMID: 29235194.
    Citations: 11     Fields:    Translation:Humans
  32. Cavallari M, Egorova S, Healy BC, Palotai M, Prieto JC, Polgar-Turcsanyi M, Tauhid S, Anderson M, Glanz B, Chitnis T, Guttmann CRG. Evaluating the Association between Enlarged Perivascular Spaces and Disease Worsening in Multiple Sclerosis. J Neuroimaging. 2018 05; 28(3):273-277. PMID: 29226505.
    Citations: 8     Fields:    Translation:Humans
  33. Cavallari M, Dai W, Guttmann CRG, Meier DS, Ngo LH, Hshieh TT, Fong TG, Schmitt E, Press DZ, Travison TG, Marcantonio ER, Jones RN, Inouye SK, Alsop DC. Longitudinal diffusion changes following postoperative delirium in older people without dementia. Neurology. 2017 Sep 05; 89(10):1020-1027. PMID: 28779010.
    Citations: 5     Fields:    Translation:Humans
  34. Cavallari M, Guttmann CRG, Inouye SK, Alsop DC. State of the Art and Promise of Structural Neuroimaging in Postoperative Delirium and Postoperative Cognitive Decline. Am J Geriatr Psychiatry. 2017 10; 25(10):1062-1063. PMID: 28802800.
    Citations:    Fields:    Translation:Humans
  35. Diaz-Cruz C, Chua AS, Malik MT, Kaplan T, Glanz BI, Egorova S, Guttmann CRG, Bakshi R, Weiner HL, Healy BC, Chitnis T. The effect of alcohol and red wine consumption on clinical and MRI outcomes in multiple sclerosis. Mult Scler Relat Disord. 2017 Oct; 17:47-53. PMID: 29055473.
    Citations: 9     Fields:    Translation:Humans
  36. Palotai M, Mike A, Cavallari M, Strammer E, Orsi G, Healy BC, Schregel K, Illes Z, Guttmann CR. Changes to the septo-fornical area might play a role in the pathogenesis of anxiety in multiple sclerosis. Mult Scler. 2018 07; 24(8):1105-1114. PMID: 28548605.
    Citations: 5     Fields:    Translation:Humans
  37. Zhao Y, Healy BC, Rotstein D, Guttmann CR, Bakshi R, Weiner HL, Brodley CE, Chitnis T. Exploration of machine learning techniques in predicting multiple sclerosis disease course. PLoS One. 2017; 12(4):e0174866. PMID: 28379999.
    Citations: 22     Fields:    Translation:Humans
  38. Healy BC, Buckle GJ, Ali EN, Egorova S, Khalid F, Tauhid S, Glanz BI, Chitnis T, Guttmann CRG, Weiner HL, Bakshi R. Characterizing Clinical and MRI Dissociation in Patients with Multiple Sclerosis. J Neuroimaging. 2017 09; 27(5):481-485. PMID: 28261936.
    Citations: 8     Fields:    Translation:Humans
  39. Sati P, Oh J, Constable RT, Evangelou N, Guttmann CR, Henry RG, Klawiter EC, Mainero C, Massacesi L, McFarland H, Nelson F, Ontaneda D, Rauscher A, Rooney WD, Samaraweera AP, Shinohara RT, Sobel RA, Solomon AJ, Treaba CA, Wuerfel J, Zivadinov R, Sicotte NL, Pelletier D, Reich DS. The central vein sign and its clinical evaluation for the diagnosis of multiple sclerosis: a consensus statement from the North American Imaging in Multiple Sclerosis Cooperative. Nat Rev Neurol. 2016 12; 12(12):714-722. PMID: 27834394.
    Citations: 62     Fields:    Translation:Humans
  40. Moroso A, Ruet A, Lamargue-Hamel D, Munsch F, Deloire M, Coupé P, Ouallet JC, Planche V, Moscufo N, Meier DS, Tourdias T, Guttmann CR, Dousset V, Brochet B. Posterior lobules of the cerebellum and information processing speed at various stages of multiple sclerosis. J Neurol Neurosurg Psychiatry. 2017 Feb; 88(2):146-151. PMID: 27789541.
    Citations: 16     Fields:    Translation:Humans
  41. Planche V, Ruet A, Coupé P, Lamargue-Hamel D, Deloire M, Pereira B, Manjon JV, Munsch F, Moscufo N, Meier DS, Guttmann CR, Dousset V, Brochet B, Tourdias T. Hippocampal microstructural damage correlates with memory impairment in clinically isolated syndrome suggestive of multiple sclerosis. Mult Scler. 2017 Aug; 23(9):1214-1224. PMID: 27780913.
    Citations: 17     Fields:    Translation:Humans
  42. Cavallari M, Guttmann CR, Jones RN, Inouye SK, Alsop DC. Reply: Neural substrates of vulnerability to post-surgical delirium with prospective diagnosis. Brain. 2016 Oct; 139(Pt 10):e55. PMID: 27343260.
    Citations:    Fields:    
  43. Stamile C, Kocevar G, Cotton F, Durand-Dubief F, Hannoun S, Frindel C, Guttmann CR, Rousseau D, Sappey-Marinier D. A Sensitive and Automatic White Matter Fiber Tracts Model for Longitudinal Analysis of Diffusion Tensor Images in Multiple Sclerosis. PLoS One. 2016; 11(5):e0156405. PMID: 27224308.
    Citations: 2     Fields:    Translation:Humans
  44. Bigourdan A, Munsch F, Coupé P, Guttmann CR, Sagnier S, Renou P, Debruxelles S, Poli M, Dousset V, Sibon I, Tourdias T. Early Fiber Number Ratio Is a Surrogate of Corticospinal Tract Integrity and Predicts Motor Recovery After Stroke. Stroke. 2016 Apr; 47(4):1053-9. PMID: 26979863.
    Citations: 20     Fields:    Translation:Humans
  45. Cavallari M, Dai W, Guttmann CR, Meier DS, Ngo LH, Hshieh TT, Callahan AE, Fong TG, Schmitt E, Dickerson BC, Press DZ, Marcantonio ER, Jones RN, Inouye SK, Alsop DC. Neural substrates of vulnerability to postsurgical delirium as revealed by presurgical diffusion MRI. Brain. 2016 Apr; 139(Pt 4):1282-94. PMID: 26920674.
    Citations: 17     Fields:    Translation:Humans
  46. Cavallari M, Palotai M, Glanz BI, Egorova S, Prieto JC, Healy BC, Chitnis T, Guttmann CR. Fatigue predicts disease worsening in relapsing-remitting multiple sclerosis patients. Mult Scler. 2016 12; 22(14):1841-1849. PMID: 26920374.
    Citations: 7     Fields:    Translation:Humans
  47. Hshieh TT, Dai W, Cavallari M, Guttmann CR, Meier DS, Schmitt EM, Dickerson BC, Press DZ, Marcantonio ER, Jones RN, Gou YR, Travison TG, Fong TG, Ngo L, Inouye SK, Alsop DC. Cerebral blood flow MRI in the nondemented elderly is not predictive of post-operative delirium but is correlated with cognitive performance. J Cereb Blood Flow Metab. 2017 Apr; 37(4):1386-1397. PMID: 27401806.
    Citations: 6     Fields:    Translation:Humans
  48. Abraham HM, Wolfson L, Moscufo N, Guttmann CR, Kaplan RF, White WB. Cardiovascular risk factors and small vessel disease of the brain: Blood pressure, white matter lesions, and functional decline in older persons. J Cereb Blood Flow Metab. 2016 Jan; 36(1):132-42. PMID: 26036933.
    Citations: 38     Fields:    Translation:Humans
  49. Hshieh TT, Fox ML, Kosar CM, Cavallari M, Guttmann CR, Alsop D, Marcantonio ER, Schmitt EM, Jones RN, Inouye SK. Head circumference as a useful surrogate for intracranial volume in older adults. Int Psychogeriatr. 2016 Jan; 28(1):157-62. PMID: 26631180.
    Citations: 3     Fields:    Translation:Humans
  50. Munsch F, Sagnier S, Asselineau J, Bigourdan A, Guttmann CR, Debruxelles S, Poli M, Renou P, Perez P, Dousset V, Sibon I, Tourdias T. Stroke Location Is an Independent Predictor of Cognitive Outcome. Stroke. 2016 Jan; 47(1):66-73. PMID: 26585396.
    Citations: 20     Fields:    Translation:Humans
  51. Guttmann CR, Rousset M, Roch JA, Hannoun S, Durand-Dubief F, Belaroussi B, Cavallari M, Rabilloud M, Sappey-Marinier D, Vukusic S, Cotton F. Multiple sclerosis lesion formation and early evolution revisited: A weekly high-resolution magnetic resonance imaging study. Mult Scler. 2016 05; 22(6):761-9. PMID: 26362901.
    Citations: 11     Fields:    Translation:Humans
  52. Chua AS, Egorova S, Anderson MC, Polgar-Turcsanyi M, Chitnis T, Weiner HL, Guttmann CR, Bakshi R, Healy BC. Handling changes in MRI acquisition parameters in modeling whole brain lesion volume and atrophy data in multiple sclerosis subjects: Comparison of linear mixed-effect models. Neuroimage Clin. 2015; 8:606-10. PMID: 26199872.
    Citations: 10     Fields:    Translation:Humans
  53. Chua AS, Egorova S, Anderson MC, Polgar-Turcsanyi M, Chitnis T, Weiner HL, Guttmann CR, Bakshi R, Healy BC. Using multiple imputation to efficiently correct cerebral MRI whole brain lesion and atrophy data in patients with multiple sclerosis. Neuroimage. 2015 Oct 01; 119:81-8. PMID: 26093330.
    Citations: 4     Fields:    Translation:Humans
  54. Cavallari M, Hshieh TT, Guttmann CR, Ngo LH, Meier DS, Schmitt EM, Marcantonio ER, Jones RN, Kosar CM, Fong TG, Press D, Inouye SK, Alsop DC. Brain atrophy and white-matter hyperintensities are not significantly associated with incidence and severity of postoperative delirium in older persons without dementia. Neurobiol Aging. 2015 Jun; 36(6):2122-9. PMID: 25824618.
    Citations: 22     Fields:    Translation:Humans
  55. Hannoun S, Roch JA, Durand-Dubief F, Vukusic S, Sappey-Marinier D, Guttmann CR, Cotton F. Weekly multimodal MRI follow-up of two multiple sclerosis active lesions presenting a transient decrease in ADC. Brain Behav. 2015 Feb; 5(2):e00307. PMID: 25642392.
    Citations: 4     Fields:    Translation:HumansCells
  56. Bakshi R, Neema M, Tauhid S, Healy BC, Glanz BI, Kim G, Miller J, Berkowitz JL, Bove R, Houtchens MK, Severson C, Stankiewicz JM, Stazzone L, Chitnis T, Guttmann CR, Weiner HL, Ceccarelli A. An expanded composite scale of MRI-defined disease severity in multiple sclerosis: MRDSS2. Neuroreport. 2014 Oct 01; 25(14):1156-61. PMID: 25100554.
    Citations: 11     Fields:    Translation:Humans
  57. Cavallari M, Ceccarelli A, Wang GY, Moscufo N, Hannoun S, Matulis CR, Jackson JS, Glanz BI, Bakshi R, Neema M, Guttmann CR. Microstructural changes in the striatum and their impact on motor and neuropsychological performance in patients with multiple sclerosis. PLoS One. 2014; 9(7):e101199. PMID: 25047083.
    Citations: 12     Fields:    Translation:Humans
  58. Cavallari M, Moscufo N, Meier D, Skudlarski P, Pearlson GD, White WB, Wolfson L, Guttmann CR. Thalamic fractional anisotropy predicts accrual of cerebral white matter damage in older subjects with small-vessel disease. J Cereb Blood Flow Metab. 2014 Aug; 34(8):1321-7. PMID: 24824915.
    Citations: 6     Fields:    Translation:Humans
  59. Zecca C, Riccitelli GC, Calabrese P, Pravatà E, Candrian U, Guttmann CR, Gobbi C. Treatment satisfaction, adherence and behavioral assessment in patients de-escalating from natalizumab to interferon ß. BMC Neurol. 2014 Feb 28; 14:38. PMID: 24576156.
    Citations: 4     Fields:    Translation:Humans
  60. Mike A, Strammer E, Aradi M, Orsi G, Perlaki G, Hajnal A, Sandor J, Banati M, Illes E, Zaitsev A, Herold R, Guttmann CR, Illes Z. Disconnection mechanism and regional cortical atrophy contribute to impaired processing of facial expressions and theory of mind in multiple sclerosis: a structural MRI study. PLoS One. 2013; 8(12):e82422. PMID: 24349280.
    Citations: 19     Fields:    Translation:Humans
  61. Chitnis T, Guttmann CR, Zaitsev A, Musallam A, Weinstock-Guttman B, Yeh A, Rodriguez M, Ness J, Gorman MP, Healy BC, Kuntz N, Chabas D, Strober JB, Waubant E, Krupp L, Pelletier D, Erickson B, Bergsland N, Zivadinov R. Quantitative MRI analysis in children with multiple sclerosis: a multicenter feasibility pilot study. BMC Neurol. 2013 Nov 13; 13:173. PMID: 24225378.
    Citations: 1     Fields:    Translation:Humans
  62. Ottoboni L, Frohlich IY, Lee M, Healy BC, Keenan BT, Xia Z, Chitnis T, Guttmann CR, Khoury SJ, Weiner HL, Hafler DA, De Jager PL. Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus. Neurology. 2013 Nov 26; 81(22):1891-9. PMID: 24174586.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  63. Purkayastha S, Fadar O, Mehregan A, Salat DH, Moscufo N, Meier DS, Guttmann CR, Fisher ND, Lipsitz LA, Sorond FA. Impaired cerebrovascular hemodynamics are associated with cerebral white matter damage. J Cereb Blood Flow Metab. 2014 Feb; 34(2):228-34. PMID: 24129749.
    Citations: 51     Fields:    Translation:HumansCTClinical Trials
  64. Egger K, Clemm von Hohenberg C, Schocke MF, Guttmann CR, Wassermann D, Wigand MC, Nachbauer W, Kremser C, Sturm B, Scheiber-Mojdehkar B, Kubicki M, Shenton ME, Boesch S. White matter changes in patients with friedreich ataxia after treatment with erythropoietin. J Neuroimaging. 2014 Sep-Oct; 24(5):504-8. PMID: 24015771.
    Citations: 9     Fields:    Translation:HumansCTClinical Trials
  65. Gobbi C, Meier DS, Cotton F, Sintzel M, Leppert D, Guttmann CR, Zecca C. Interferon beta 1b following natalizumab discontinuation: one year, randomized, prospective, pilot trial. BMC Neurol. 2013 Aug 02; 13:101. PMID: 23915113.
    Citations: 11     Fields:    Translation:Humans
  66. Papp KV, Kaplan RF, Springate B, Moscufo N, Wakefield DB, Guttmann CR, Wolfson L. Processing speed in normal aging: effects of white matter hyperintensities and hippocampal volume loss. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2014; 21(2):197-213. PMID: 23895570.
    Citations: 23     Fields:    Translation:Humans
  67. Bove R, Musallam A, Healy BC, Houtchens M, Glanz BI, Khoury S, Guttmann CR, De Jager PL, Chitnis T. No sex-specific difference in disease trajectory in multiple sclerosis patients before and after age 50. BMC Neurol. 2013 Jul 03; 13:73. PMID: 23822612.
    Citations: 10     Fields:    Translation:Humans
  68. Wolfson L, Wakefield DB, Moscufo N, Kaplan RF, Hall CB, Schmidt JA, Guttmann CR, White WB. Rapid buildup of brain white matter hyperintensities over 4 years linked to ambulatory blood pressure, mobility, cognition, and depression in old persons. J Gerontol A Biol Sci Med Sci. 2013 Nov; 68(11):1387-94. PMID: 23766429.
    Citations: 25     Fields:    Translation:Humans
  69. Clemm von Hohenberg C, Schocke MF, Wigand MC, Nachbauer W, Guttmann CR, Kubicki M, Shenton ME, Boesch S, Egger K. Radial diffusivity in the cerebellar peduncles correlates with clinical severity in Friedreich ataxia. Neurol Sci. 2013 Aug; 34(8):1459-62. PMID: 23640016.
    Citations: 11     Fields:    Translation:Humans
  70. Kalincik T, Guttmann CR, Krasensky J, Vaneckova M, Lelkova P, Tyblova M, Seidl Z, De Jager PL, Havrdova E, Horakova D. Multiple sclerosis susceptibility loci do not alter clinical and MRI outcomes in clinically isolated syndrome. Genes Immun. 2013 Jun; 14(4):244-8. PMID: 23575354.
    Citations: 6     Fields:    Translation:Humans
  71. Cavallari M, Moscufo N, Skudlarski P, Meier D, Panzer VP, Pearlson GD, White WB, Wolfson L, Guttmann CR. Mobility impairment is associated with reduced microstructural integrity of the inferior and superior cerebellar peduncles in elderly with no clinical signs of cerebellar dysfunction. Neuroimage Clin. 2013; 2:332-40. PMID: 24179787.
    Citations: 10     Fields:    
  72. White WB, Marfatia R, Schmidt J, Wakefield DB, Kaplan RF, Bohannon RW, Hall CB, Guttmann CR, Moscufo N, Fellows D, Wolfson L. INtensive versus standard ambulatory blood pressure lowering to prevent functional DeclINe in the ElderlY (INFINITY). Am Heart J. 2013 Mar; 165(3):258-265.e1. PMID: 23453090.
    Citations: 18     Fields:    Translation:Humans
  73. Ceccarelli A, Jackson JS, Tauhid S, Arora A, Gorky J, Dell'Oglio E, Bakshi A, Chitnis T, Khoury SJ, Weiner HL, Guttmann CR, Bakshi R, Neema M. The impact of lesion in-painting and registration methods on voxel-based morphometry in detecting regional cerebral gray matter atrophy in multiple sclerosis. AJNR Am J Neuroradiol. 2012 Sep; 33(8):1579-85. PMID: 22460341.
    Citations: 34     Fields:    Translation:Humans
  74. Hannoun S, Durand-Dubief F, Confavreux C, Ibarrola D, Streichenberger N, Cotton F, Guttmann CR, Sappey-Marinier D. Diffusion tensor-MRI evidence for extra-axonal neuronal degeneration in caudate and thalamic nuclei of patients with multiple sclerosis. AJNR Am J Neuroradiol. 2012 Aug; 33(7):1363-8. PMID: 22383236.
    Citations: 25     Fields:    Translation:HumansCells
  75. Gorman MP, Tillema JM, Ciliax AM, Guttmann CR, Chitnis T. Daclizumab use in patients with pediatric multiple sclerosis. Arch Neurol. 2012 Jan; 69(1):78-81. PMID: 22232346.
    Citations: 17     Fields:    Translation:HumansCTClinical Trials
  76. Moodie J, Healy BC, Buckle GJ, Gauthier SA, Glanz BI, Arora A, Ceccarelli A, Tauhid S, Han XM, Venkataraman A, Chitnis T, Khoury SJ, Guttmann CR, Weiner HL, Neema M, Bakshi R. Magnetic resonance disease severity scale (MRDSS) for patients with multiple sclerosis: a longitudinal study. J Neurol Sci. 2012 Apr 15; 315(1-2):49-54. PMID: 22209496.
    Citations: 9     Fields:    Translation:Humans
  77. White WB, Wolfson L, Wakefield DB, Hall CB, Campbell P, Moscufo N, Schmidt J, Kaplan RF, Pearlson G, Guttmann CR. Average daily blood pressure, not office blood pressure, is associated with progression of cerebrovascular disease and cognitive decline in older people. Circulation. 2011 Nov 22; 124(21):2312-9. PMID: 22105196.
    Citations: 33     Fields:    Translation:HumansCells
  78. Fähndrich S, Guttmann C, Bals R. [Chronic obstructive pulmonary disease: pathophysiology, diagnosis, and therapy]. Dtsch Med Wochenschr. 2011 Sep; 136(37):1847-60; quiz 1861-2. PMID: 21898277.
    Citations: 1     Fields:    Translation:Humans
  79. Sorond FA, Kiely DK, Galica A, Moscufo N, Serrador JM, Iloputaife I, Egorova S, Dell'Oglio E, Meier DS, Newton E, Milberg WP, Guttmann CR, Lipsitz LA. Neurovascular coupling is impaired in slow walkers: the MOBILIZE Boston Study. Ann Neurol. 2011 Aug; 70(2):213-20. PMID: 21674588.
    Citations: 48     Fields:    Translation:Humans
  80. Tate DF, Sampat M, Harezlak J, Fiecas M, Hogan J, Dewey J, McCaffrey D, Branson D, Russell T, Conley J, Taylor M, Schifitto G, Schifitto G, Zhong J, Daar ES, Alger J, Brown M, Singer E, Campbell T, McMahon D, Tso Y, Matesan J, Letendre S, Paulose S, Gaugh M, Tripoli C, Yiannoutsos C, Bigler ED, Cohen RA, Guttmann CR, Navia B. Regional areas and widths of the midsagittal corpus callosum among HIV-infected patients on stable antiretroviral therapies. J Neurovirol. 2011 Aug; 17(4):368-79. PMID: 21556960.
    Citations: 21     Fields:    Translation:HumansCells
  81. Klein JP, Arora A, Neema M, Healy BC, Tauhid S, Goldberg-Zimring D, Chavarro-Nieto C, Stankiewicz JM, Cohen AB, Buckle GJ, Houtchens MK, Ceccarelli A, Dell'Oglio E, Guttmann CR, Alsop DC, Hackney DB, Bakshi R. A 3T MR imaging investigation of the topography of whole spinal cord atrophy in multiple sclerosis. AJNR Am J Neuroradiol. 2011 Jun-Jul; 32(6):1138-42. PMID: 21527570.
    Citations: 16     Fields:    Translation:Humans
  82. Moscufo N, Wolfson L, Meier D, Liguori M, Hildenbrand PG, Wakefield D, Schmidt JA, Pearlson GD, Guttmann CR. Mobility decline in the elderly relates to lesion accrual in the splenium of the corpus callosum. Age (Dordr). 2012 Apr; 34(2):405-14. PMID: 21505765.
    Citations: 18     Fields:    Translation:HumansCells
  83. Stankiewicz JM, Glanz BI, Healy BC, Arora A, Neema M, Benedict RH, Guss ZD, Tauhid S, Buckle GJ, Houtchens MK, Khoury SJ, Weiner HL, Guttmann CR, Bakshi R. Brain MRI lesion load at 1.5T and 3T versus clinical status in multiple sclerosis. J Neuroimaging. 2011 Apr; 21(2):e50-6. PMID: 19888926.
    Citations: 47     Fields:    Translation:Humans
  84. Cohen AB, Neema M, Arora A, Dell'oglio E, Benedict RH, Tauhid S, Goldberg-Zimring D, Chavarro-Nieto C, Ceccarelli A, Klein JP, Stankiewicz JM, Houtchens MK, Buckle GJ, Alsop DC, Guttmann CR, Bakshi R. The relationships among MRI-defined spinal cord involvement, brain involvement, and disability in multiple sclerosis. J Neuroimaging. 2012 Apr; 22(2):122-8. PMID: 21447024.
    Citations: 44     Fields:    Translation:HumansCells
  85. Holland CM, Charil A, Csapo I, Liptak Z, Ichise M, Khoury SJ, Bakshi R, Weiner HL, Guttmann CR. The relationship between normal cerebral perfusion patterns and white matter lesion distribution in 1,249 patients with multiple sclerosis. J Neuroimaging. 2012 Apr; 22(2):129-36. PMID: 21447022.
    Citations: 33     Fields:    Translation:HumansCells
  86. Liguori M, Meier DS, Hildenbrand P, Healy BC, Chitnis T, Baruch NF, Khoury SJ, Weiner HL, Bakshi R, Barkhof F, Guttmann CR. One year activity on subtraction MRI predicts subsequent 4 year activity and progression in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2011 Oct; 82(10):1125-31. PMID: 21429902.
    Citations: 4     Fields:    Translation:Humans
  87. Mike A, Glanz BI, Hildenbrand P, Meier D, Bolden K, Liguori M, Dell'Oglio E, Healy BC, Bakshi R, Guttmann CR. Identification and clinical impact of multiple sclerosis cortical lesions as assessed by routine 3T MR imaging. AJNR Am J Neuroradiol. 2011 Mar; 32(3):515-21. PMID: 21310857.
    Citations: 23     Fields:    Translation:HumansCells
  88. Liguori M, Healy BC, Glanz BI, Khoury SJ, Moscufo N, Weiner HL, De Jager PL, Guttmann CR. HLA (A-B-C and -DRB1) alleles and brain MRI changes in multiple sclerosis: a longitudinal study. Genes Immun. 2011 Apr; 12(3):183-90. PMID: 21179117.
    Citations: 3     Fields:    Translation:Humans
  89. Xia Z, Chibnik LB, Glanz BI, Liguori M, Shulman JM, Tran D, Khoury SJ, Chitnis T, Holyoak T, Weiner HL, Guttmann CR, De Jager PL. A putative Alzheimer's disease risk allele in PCK1 influences brain atrophy in multiple sclerosis. PLoS One. 2010 Nov 30; 5(11):e14169. PMID: 21152065.
    Citations: 11     Fields:    Translation:Humans
  90. Torelli F, Moscufo N, Garreffa G, Placidi F, Romigi A, Zannino S, Bozzali M, Fasano F, Giulietti G, Djonlagic I, Malhotra A, Marciani MG, Guttmann CR. Cognitive profile and brain morphological changes in obstructive sleep apnea. Neuroimage. 2011 Jan 15; 54(2):787-93. PMID: 20888921.
    Citations: 100     Fields:    Translation:Humans
  91. Khoury SJ, Healy BC, Kivisäkk P, Viglietta V, Egorova S, Guttmann CR, Wedgwood JF, Hafler DA, Weiner HL, Buckle G, Cook S, Reddy S. A randomized controlled double-masked trial of albuterol add-on therapy in patients with multiple sclerosis. Arch Neurol. 2010 Sep; 67(9):1055-61. PMID: 20837847.
    Citations: 13     Fields:    Translation:Humans
  92. Meier DS, Balashov KE, Healy B, Weiner HL, Guttmann CR. Seasonal prevalence of MS disease activity. Neurology. 2010 Aug 31; 75(9):799-806. PMID: 20805526.
    Citations: 21     Fields:    Translation:Humans
  93. Healy BC, Liguori M, Tran D, Chitnis T, Glanz B, Wolfish C, Gauthier S, Buckle G, Houtchens M, Stazzone L, Khoury S, Hartzmann R, Fernandez-Vina M, Hafler DA, Weiner HL, Guttmann CR, De Jager PL. HLA B*44: protective effects in MS susceptibility and MRI outcome measures. Neurology. 2010 Aug 17; 75(7):634-40. PMID: 20713950.
    Citations: 24     Fields:    Translation:Humans
  94. Moraal B, van den Elskamp IJ, Knol DL, Uitdehaag BM, Geurts JJ, Vrenken H, Pouwels PJ, van Schijndel RA, Meier DS, Guttmann CR, Barkhof F. Long-interval T2-weighted subtraction magnetic resonance imaging: a powerful new outcome measure in multiple sclerosis trials. Ann Neurol. 2010 May; 67(5):667-75. PMID: 20437564.
    Citations: 13     Fields:    Translation:HumansCTClinical Trials
  95. Sampat MP, Healy BC, Meier DS, Dell'Oglio E, Liguori M, Guttmann CR. Disease modeling in multiple sclerosis: assessment and quantification of sources of variability in brain parenchymal fraction measurements. Neuroimage. 2010 Oct 01; 52(4):1367-73. PMID: 20362675.
    Citations: 13     Fields:    Translation:Humans
  96. Dewey J, Hana G, Russell T, Price J, McCaffrey D, Harezlak J, Sem E, Anyanwu JC, Guttmann CR, Navia B, Cohen R, Tate DF. Reliability and validity of MRI-based automated volumetry software relative to auto-assisted manual measurement of subcortical structures in HIV-infected patients from a multisite study. Neuroimage. 2010 Jul 15; 51(4):1334-44. PMID: 20338250.
    Citations: 63     Fields:    Translation:Humans
  97. Wakefield DB, Moscufo N, Guttmann CR, Kuchel GA, Kaplan RF, Pearlson G, Wolfson L. White matter hyperintensities predict functional decline in voiding, mobility, and cognition in older adults. J Am Geriatr Soc. 2010 Feb; 58(2):275-81. PMID: 20374403.
    Citations: 42     Fields:    Translation:HumansCells
  98. Sampat MP, Berger AM, Healy BC, Hildenbrand P, Vass J, Meier DS, Chitnis T, Weiner HL, Bakshi R, Guttmann CR. Regional white matter atrophy--based classification of multiple sclerosis in cross-sectional and longitudinal data. AJNR Am J Neuroradiol. 2009 Oct; 30(9):1731-9. PMID: 19696139.
    Citations: 2     Fields:    Translation:HumansCells
  99. Healy BC, Ali EN, Guttmann CR, Chitnis T, Glanz BI, Buckle G, Houtchens M, Stazzone L, Moodie J, Berger AM, Duan Y, Bakshi R, Khoury S, Weiner H, Ascherio A. Smoking and disease progression in multiple sclerosis. Arch Neurol. 2009 Jul; 66(7):858-64. PMID: 19597087.
    Citations: 54     Fields:    Translation:Humans
  100. Gauthier SA, Glanz BI, Mandel M, Tsagkaropoulos A, Neema M, Stankiewicz J, Arora A, Duan Y, Liptak Z, Egorova S, Buckle GJ, Bakshi R, Guttmann CR, Khoury SJ, Weiner HL. Incidence and factors associated with treatment failure in the CLIMB multiple sclerosis cohort study. J Neurol Sci. 2009 Sep 15; 284(1-2):116-9. PMID: 19428028.
    Citations: 7     Fields:    Translation:Humans
  101. Moscufo N, Guttmann CR, Meier D, Csapo I, Hildenbrand PG, Healy BC, Schmidt JA, Wolfson L. Brain regional lesion burden and impaired mobility in the elderly. Neurobiol Aging. 2011 Apr; 32(4):646-54. PMID: 19428145.
    Citations: 31     Fields:    Translation:HumansCells
  102. Kuchel GA, Moscufo N, Guttmann CR, Zeevi N, Wakefield D, Schmidt J, Dubeau CE, Wolfson L. Localization of brain white matter hyperintensities and urinary incontinence in community-dwelling older adults. J Gerontol A Biol Sci Med Sci. 2009 Aug; 64(8):902-9. PMID: 19386575.
    Citations: 31     Fields:    Translation:Humans
  103. Stankiewicz JM, Neema M, Alsop DC, Healy BC, Arora A, Buckle GJ, Chitnis T, Guttmann CR, Hackney D, Bakshi R. Spinal cord lesions and clinical status in multiple sclerosis: A 1.5 T and 3 T MRI study. J Neurol Sci. 2009 Apr 15; 279(1-2):99-105. PMID: 19178916.
    Citations: 34     Fields:    Translation:Humans
  104. Kaplan RF, Cohen RA, Moscufo N, Guttmann C, Chasman J, Buttaro M, Hall CH, Wolfson L. Demographic and biological influences on cognitive reserve. J Clin Exp Neuropsychol. 2009 Oct; 31(7):868-76. PMID: 19333862.
    Citations: 12     Fields:    Translation:Humans
  105. Neema M, Goldberg-Zimring D, Guss ZD, Healy BC, Guttmann CR, Houtchens MK, Weiner HL, Horsfield MA, Hackney DB, Alsop DC, Bakshi R. 3 T MRI relaxometry detects T2 prolongation in the cerebral normal-appearing white matter in multiple sclerosis. Neuroimage. 2009 Jul 01; 46(3):633-41. PMID: 19281850.
    Citations: 28     Fields:    Translation:HumansCells
  106. Jefferson AL, Holland CM, Tate DF, Csapo I, Poppas A, Cohen RA, Guttmann CR. Atlas-derived perfusion correlates of white matter hyperintensities in patients with reduced cardiac output. Neurobiol Aging. 2011 Jan; 32(1):133-9. PMID: 19269713.
    Citations: 9     Fields:    Translation:Humans
  107. Gauthier SA, Berger AM, Liptak Z, Duan Y, Egorova S, Buckle GJ, Glanz BI, Khoury SJ, Bakshi R, Weiner HL, Guttmann CR. Rate of brain atrophy in benign vs early multiple sclerosis. Arch Neurol. 2009 Feb; 66(2):234-7. PMID: 19204160.
    Citations: 10     Fields:    Translation:Humans
  108. Neema M, Arora A, Healy BC, Guss ZD, Brass SD, Duan Y, Buckle GJ, Glanz BI, Stazzone L, Khoury SJ, Weiner HL, Guttmann CR, Bakshi R. Deep gray matter involvement on brain MRI scans is associated with clinical progression in multiple sclerosis. J Neuroimaging. 2009 Jan; 19(1):3-8. PMID: 19192042.
    Citations: 38     Fields:    Translation:Humans
  109. Healy BC, Hayden DL, Sampat MP, Bakshi R, Guttmann CR. Unbiased treatment effect estimates by modeling the disease process of multiple sclerosis. J Neurol Sci. 2009 Mar 15; 278(1-2):54-9. PMID: 19121526.
    Citations:    Fields:    Translation:Humans
  110. Desikan RS, Cabral HJ, Fischl B, Guttmann CR, Blacker D, Hyman BT, Albert MS, Killiany RJ. Temporoparietal MR imaging measures of atrophy in subjects with mild cognitive impairment that predict subsequent diagnosis of Alzheimer disease. AJNR Am J Neuroradiol. 2009 Mar; 30(3):532-8. PMID: 19112067.
    Citations: 38     Fields:    Translation:Humans
  111. Moraal B, Meier DS, Poppe PA, Geurts JJ, Vrenken H, Jonker WM, Knol DL, van Schijndel RA, Pouwels PJ, Pohl C, Bauer L, Sandbrink R, Guttmann CR, Barkhof F. Subtraction MR images in a multiple sclerosis multicenter clinical trial setting. Radiology. 2009 Feb; 250(2):506-14. PMID: 19037018.
    Citations: 17     Fields:    Translation:Humans
  112. Bakshi R, Neema M, Healy BC, Liptak Z, Betensky RA, Buckle GJ, Gauthier SA, Stankiewicz J, Meier D, Egorova S, Arora A, Guss ZD, Glanz B, Khoury SJ, Guttmann CR, Weiner HL. Predicting clinical progression in multiple sclerosis with the magnetic resonance disease severity scale. Arch Neurol. 2008 Nov; 65(11):1449-53. PMID: 19001162.
    Citations: 19     Fields:    Translation:Humans
  113. Viglietta V, Bourcier K, Buckle GJ, Healy B, Weiner HL, Hafler DA, Egorova S, Guttmann CR, Rusche JR, Khoury SJ. CTLA4Ig treatment in patients with multiple sclerosis: an open-label, phase 1 clinical trial. Neurology. 2008 Sep 16; 71(12):917-24. PMID: 18794494.
    Citations: 36     Fields:    Translation:HumansCTClinical Trials
  114. Meier, Dominik; Guttmann, Charles R.G. Overlay of tinted images for visualizing change in serial radiologic images. 2008.
  115. Desikan RS, Fischl B, Cabral HJ, Kemper TL, Guttmann CR, Blacker D, Hyman BT, Albert MS, Killiany RJ. MRI measures of temporoparietal regions show differential rates of atrophy during prodromal AD. Neurology. 2008 Sep 09; 71(11):819-25. PMID: 18672473.
    Citations: 40     Fields:    Translation:Humans
  116. Bakshi R, Thompson AJ, Rocca MA, Pelletier D, Dousset V, Barkhof F, Inglese M, Guttmann CR, Horsfield MA, Filippi M. MRI in multiple sclerosis: current status and future prospects. Lancet Neurol. 2008 Jul; 7(7):615-25. PMID: 18565455.
    Citations: 109     Fields:    Translation:Humans
  117. Liptak Z, Berger AM, Sampat MP, Charil A, Felsovalyi O, Healy BC, Hildenbrand P, Khoury SJ, Weiner HL, Bakshi R, Guttmann CR. Medulla oblongata volume: a biomarker of spinal cord damage and disability in multiple sclerosis. AJNR Am J Neuroradiol. 2008 Sep; 29(8):1465-70. PMID: 18556361.
    Citations: 14     Fields:    Translation:Humans
  118. Moraal B, Roosendaal SD, Pouwels PJ, Vrenken H, van Schijndel RA, Meier DS, Guttmann CR, Geurts JJ, Barkhof F. Multi-contrast, isotropic, single-slab 3D MR imaging in multiple sclerosis. Eur Radiol. 2008 Oct; 18(10):2311-20. PMID: 18509658.
    Citations: 32     Fields:    Translation:Humans
  119. Wisco JJ, Rosene DL, Killiany RJ, Moss MB, Warfield SK, Egorova S, Wu Y, Liptak Z, Warner J, Guttmann CR. A rhesus monkey reference label atlas for template driven segmentation. J Med Primatol. 2008 Oct; 37(5):250-60. PMID: 18466282.
    Citations: 4     Fields:    Translation:Animals
  120. Holland CM, Smith EE, Csapo I, Gurol ME, Brylka DA, Killiany RJ, Blacke