Harvard Catalyst Profiles

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Thorsten Roman Mempel, Ph.D., M.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI163223 (MEMPEL, THORSTEN ROMAN) Jun 1, 2021 - May 31, 2026
    A mechanism to minimize auto-reactivity in the tissue-resident memory T cell pool
    Role: Principal Investigator
  2. R21AR070981 (MEMPEL, THORSTEN ROMAN) Aug 1, 2017 - Jul 31, 2019
    Visualizing the signals that drive resident memory T cell formation in skin
    Role: Principal Investigator
  3. R01AI123349 (MEMPEL, THORSTEN ROMAN) Mar 1, 2017 - Feb 28, 2022
    Cellular mechanisms by which exhausted T cell responses are restored
    Role: Principal Investigator
  4. U19CA179563 (BREAKEFIELD, XANDRA OWENS) Sep 1, 2013 - Aug 31, 2019
    exRNA released by glioblastoma alters brain microenvironment
    Role: Co-Principal Investigator
  5. R01AI097052 (MEMPEL, THORSTEN ROMAN) Aug 1, 2013 - Jul 31, 2017
    Migratory Properties of HIV-infected T cells in vivo
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Mempel TR, Krappmann D. Combining precision oncology and immunotherapy by targeting the MALT1 protease. J Immunother Cancer. 2022 10; 10(10). PMID: 36270731; PMCID: PMC9594517.
    Citations:    Fields:    Translation:Humans
  2. Crainiciuc G, Palomino-Segura M, Molina-Moreno M, Sicilia J, Aragones DG, Li JLY, Madurga R, Adrover JM, Aroca-Crevillén A, Martin-Salamanca S, Del Valle AS, Castillo SD, Welch HCE, Soehnlein O, Graupera M, Sánchez-Cabo F, Zarbock A, Smithgall TE, Di Pilato M, Mempel TR, Tharaux PL, González SF, Ayuso-Sacido A, Ng LG, Calvo GF, González-Díaz I, Díaz-de-María F, Hidalgo A. Behavioural immune landscapes of inflammation. Nature. 2022 01; 601(7893):415-421. PMID: 34987220.
    Citations: 8     Fields:    Translation:AnimalsCells
  3. Ozga AJ, Chow MT, Lopes ME, Servis RL, Di Pilato M, Dehio P, Lian J, Mempel TR, Luster AD. CXCL10 chemokine regulates heterogeneity of the CD8+ T cell response and viral set point during chronic infection. Immunity. 2022 01 11; 55(1):82-97.e8. PMID: 34847356; PMCID: PMC8755631.
    Citations:    Fields:    Translation:AnimalsCells
  4. Di Pilato M, Kfuri-Rubens R, Pruessmann JN, Ozga AJ, Messemaker M, Cadilha BL, Sivakumar R, Cianciaruso C, Warner RD, Marangoni F, Carrizosa E, Lesch S, Billingsley J, Perez-Ramos D, Zavala F, Rheinbay E, Luster AD, Gerner MY, Kobold S, Pittet MJ, Mempel TR. CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment. Cell. 2021 08 19; 184(17):4512-4530.e22. PMID: 34343496; PMCID: PMC8719451.
    Citations: 21     Fields:    Translation:AnimalsCells
  5. Marangoni F, Zhakyp A, Corsini M, Geels SN, Carrizosa E, Thelen M, Mani V, Prüßmann JN, Warner RD, Ozga AJ, Di Pilato M, Othy S, Mempel TR. Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop. Cell. 2021 07 22; 184(15):3998-4015.e19. PMID: 34157302; PMCID: PMC8664158.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  6. Cadilha BL, Benmebarek MR, Dorman K, Oner A, Lorenzini T, Obeck H, Vänttinen M, Di Pilato M, Pruessmann JN, Stoiber S, Huynh D, Märkl F, Seifert M, Manske K, Suarez-Gosalvez J, Zeng Y, Lesch S, Karches CH, Heise C, Gottschlich A, Thomas M, Marr C, Zhang J, Pandey D, Feuchtinger T, Subklewe M, Mempel TR, Endres S, Kobold S. Combined tumor-directed recruitment and protection from immune suppression enable CAR T cell efficacy in solid tumors. Sci Adv. 2021 06; 7(24). PMID: 34108220; PMCID: PMC8189699.
    Citations: 14     Fields:    Translation:HumansCells
  7. Lesch S, Blumenberg V, Stoiber S, Gottschlich A, Ogonek J, Cadilha BL, Dantes Z, Rataj F, Dorman K, Lutz J, Karches CH, Heise C, Kurzay M, Larimer BM, Grassmann S, Rapp M, Nottebrock A, Kruger S, Tokarew N, Metzger P, Hoerth C, Benmebarek MR, Dhoqina D, Grünmeier R, Seifert M, Oener A, Umut Ö, Joaquina S, Vimeux L, Tran T, Hank T, Baba T, Huynh D, Megens RTA, Janssen KP, Jastroch M, Lamp D, Ruehland S, Di Pilato M, Pruessmann JN, Thomas M, Marr C, Ormanns S, Reischer A, Hristov M, Tartour E, Donnadieu E, Rothenfusser S, Duewell P, König LM, Schnurr M, Subklewe M, Liss AS, Halama N, Reichert M, Mempel TR, Endres S, Kobold S. T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours. Nat Biomed Eng. 2021 11; 5(11):1246-1260. PMID: 34083764; PMCID: PMC7611996.
    Citations: 11     Fields:    Translation:AnimalsCells
  8. Usmani SM, Mempel TR. Cancer cells relax and resist cytotoxic attack. Immunity. 2021 05 11; 54(5):853-855. PMID: 33979583.
    Citations:    Fields:    Translation:HumansCells
  9. Heckler M, Ali LR, Clancy-Thompson E, Qiang L, Ventre KS, Lenehan P, Roehle K, Luoma A, Boelaars K, Peters V, McCreary J, Boschert T, Wang ES, Suo S, Marangoni F, Mempel TR, Long HW, Wucherpfennig KW, Dougan M, Gray NS, Yuan GC, Goel S, Tolaney SM, Dougan SK. Inhibition of CDK4/6 Promotes CD8 T-cell Memory Formation. Cancer Discov. 2021 10; 11(10):2564-2581. PMID: 33941591; PMCID: PMC8487897.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  10. Mani V, Bromley SK, Äijö T, Mora-Buch R, Carrizosa E, Warner RD, Hamze M, Sen DR, Chasse AY, Lorant A, Griffith JW, Rahimi RA, McEntee CP, Jeffrey KL, Marangoni F, Travis MA, Lacy-Hulbert A, Luster AD, Mempel TR. Migratory DCs activate TGF-ß to precondition naïve CD8+ T cells for tissue-resident memory fate. Science. 2019 10 11; 366(6462). PMID: 31601741; PMCID: PMC6939608.
    Citations: 50     Fields:    Translation:AnimalsCells
  11. Di Pilato M, Kim EY, Cadilha BL, Prüßmann JN, Nasrallah MN, Seruggia D, Usmani SM, Misale S, Zappulli V, Carrizosa E, Mani V, Ligorio M, Warner RD, Medoff BD, Marangoni F, Villani AC, Mempel TR. Targeting the CBM complex causes Treg cells to prime tumours for immune checkpoint therapy. Nature. 2019 06; 570(7759):112-116. PMID: 31092922; PMCID: PMC6656391.
    Citations: 63     Fields:    Translation:AnimalsCells
  12. Miyabe Y, Miyabe C, Mani V, Mempel TR, Luster AD. Atypical complement receptor C5aR2 transports C5a to initiate neutrophil adhesion and inflammation. Sci Immunol. 2019 05 10; 4(35). PMID: 31076525.
    Citations: 17     Fields:    Translation:AnimalsCells
  13. Mempel TR, Marangoni F. Guidance factors orchestrating regulatory T cell positioning in tissues during development, homeostasis, and response. Immunol Rev. 2019 05; 289(1):129-141. PMID: 30977195; PMCID: PMC6499397.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  14. Usmani SM, Murooka TT, Deruaz M, Koh WH, Sharaf RR, Di Pilato M, Power KA, Lopez P, Hnatiuk R, Vrbanac VD, Tager AM, Allen TM, Luster AD, Mempel TR. HIV-1 Balances the Fitness Costs and Benefits of Disrupting the Host Cell Actin Cytoskeleton Early after Mucosal Transmission. Cell Host Microbe. 2019 01 09; 25(1):73-86.e5. PMID: 30629922; PMCID: PMC6456338.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  15. Broekman ML, Maas SLN, Abels ER, Mempel TR, Krichevsky AM, Breakefield XO. Multidimensional communication in the microenvirons of glioblastoma. Nat Rev Neurol. 2018 08; 14(8):482-495. PMID: 29985475; PMCID: PMC6425928.
    Citations: 160     Fields:    Translation:Humans
  16. Pizzagalli DU, Farsakoglu Y, Palomino-Segura M, Palladino E, Sintes J, Marangoni F, Mempel TR, Koh WH, Murooka TT, Thelen F, Stein JV, Pozzi G, Thelen M, Krause R, Gonzalez SF. Leukocyte Tracking Database, a collection of immune cell tracks from intravital 2-photon microscopy videos. Sci Data. 2018 07 17; 5:180129. PMID: 30015806.
    Citations: 3     Fields:    Translation:AnimalsCells
  17. Sorensen EW, Lian J, Ozga AJ, Miyabe Y, Ji SW, Bromley SK, Mempel TR, Luster AD. CXCL10 stabilizes T cell-brain endothelial cell adhesion leading to the induction of cerebral malaria. JCI Insight. 2018 04 19; 3(8). PMID: 29669942.
    Citations: 26     Fields:    Translation:AnimalsCells
  18. Marangoni F, Zhang R, Mani V, Thelen M, Ali Akbar NJ, Warner RD, Äijö T, Zappulli V, Martinez GJ, Turka LA, Mempel TR. Tumor Tolerance-Promoting Function of Regulatory T Cells Is Optimized by CD28, but Strictly Dependent on Calcineurin. J Immunol. 2018 05 15; 200(10):3647-3661. PMID: 29661826; PMCID: PMC5940497.
    Citations: 7     Fields:    Translation:AnimalsCells
  19. Zhang R, Sage PT, Finn K, Huynh A, Blazar BR, Marangoni F, Mempel TR, Sharpe AH, Turka LA. Correction: B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells. J Immunol. 2018 04 01; 200(7):2505-2506. PMID: 29475985.
    Citations:    Fields:    
  20. Raynaud-Messina B, Bracq L, Dupont M, Souriant S, Usmani SM, Proag A, Pingris K, Soldan V, Thibault C, Capilla F, Al Saati T, Gennero I, Jurdic P, Jolicoeur P, Davignon JL, Mempel TR, Benichou S, Maridonneau-Parini I, Vérollet C. Bone degradation machinery of osteoclasts: An HIV-1 target that contributes to bone loss. Proc Natl Acad Sci U S A. 2018 03 13; 115(11):E2556-E2565. PMID: 29463701; PMCID: PMC5856515.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  21. Zhang R, Sage PT, Finn K, Huynh A, Blazar BR, Marangoni F, Mempel TR, Sharpe AH, Turka LA. B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells. J Immunol. 2017 12 15; 199(12):3972-3980. PMID: 29093061; PMCID: PMC5716898.
    Citations: 8     Fields:    Translation:AnimalsCells
  22. Janssen E, Kumari S, Tohme M, Ullas S, Barrera V, Tas JM, Castillo-Rama M, Bronson RT, Usmani SM, Irvine DJ, Mempel TR, Geha RS. DOCK8 enforces immunological tolerance by promoting IL-2 signaling and immune synapse formation in Tregs. JCI Insight. 2017 10 05; 2(19). PMID: 28978806; PMCID: PMC5841868.
    Citations: 15     Fields:    Translation:AnimalsCells
  23. Deruaz M, Murooka TT, Ji S, Gavin MA, Vrbanac VD, Lieberman J, Tager AM, Mempel TR, Luster AD. Chemoattractant-mediated leukocyte trafficking enables HIV dissemination from the genital mucosa. JCI Insight. 2017 04 06; 2(7):e88533. PMID: 28405607.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  24. Miyabe Y, Miyabe C, Murooka TT, Kim EY, Newton GA, Kim ND, Haribabu B, Luscinskas FW, Mempel TR, Luster AD. Complement C5a Receptor is the Key Initiator of Neutrophil Adhesion Igniting Immune Complex-induced Arthritis. Sci Immunol. 2017 Jan; 2(7). PMID: 28529998.
    Citations: 32     Fields:    
  25. Pucci F, Garris C, Lai CP, Newton A, Pfirschke C, Engblom C, Alvarez D, Sprachman M, Evavold C, Magnuson A, von Andrian UH, Glatz K, Breakefield XO, Mempel TR, Weissleder R, Pittet MJ. SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions. Science. 2016 Apr 08; 352(6282):242-6. PMID: 26989197.
    Citations: 122     Fields:    Translation:HumansAnimalsCells
  26. Benechet AP, Menon M, Xu D, Samji T, Maher L, Murooka TT, Mempel TR, Sheridan BS, Lemoine FM, Khanna KM. T cell-intrinsic S1PR1 regulates endogenous effector T-cell egress dynamics from lymph nodes during infection. Proc Natl Acad Sci U S A. 2016 Feb 23; 113(8):2182-7. PMID: 26862175; PMCID: PMC4776484.
    Citations: 30     Fields:    Translation:AnimalsCells
  27. Sharaf R, Mempel TR, Murooka TT. Visualizing the Behavior of HIV-Infected T Cells In Vivo Using Multiphoton Intravital Microscopy. Methods Mol Biol. 2016; 1354:189-201. PMID: 26714713; PMCID: PMC5679213.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  28. Symeonides M, Murooka TT, Bellfy LN, Roy NH, Mempel TR, Thali M. HIV-1-Induced Small T Cell Syncytia Can Transfer Virus Particles to Target Cells through Transient Contacts. Viruses. 2015 Dec 12; 7(12):6590-603. PMID: 26703714.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  29. Carrizosa E, Mempel TR. Immunology: In the right place at the right time. Nature. 2015 Dec 10; 528(7581):205-6. PMID: 26605531.
    Citations: 1     Fields:    Translation:AnimalsCells
  30. van der Vos KE, Abels ER, Zhang X, Lai C, Carrizosa E, Oakley D, Prabhakar S, Mardini O, Crommentuijn MH, Skog J, Krichevsky AM, Stemmer-Rachamimov A, Mempel TR, El Khoury J, Hickman SE, Breakefield XO. Directly visualized glioblastoma-derived extracellular vesicles transfer RNA to microglia/macrophages in the brain. Neuro Oncol. 2016 Jan; 18(1):58-69. PMID: 26433199; PMCID: PMC4677420.
    Citations: 143     Fields:    Translation:HumansAnimalsCells
  31. Sewald X, Ladinsky MS, Uchil PD, Beloor J, Pi R, Herrmann C, Motamedi N, Murooka TT, Brehm MA, Greiner DL, Shultz LD, Mempel TR, Bjorkman PJ, Kumar P, Mothes W. Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection. Science. 2015 Oct 30; 350(6260):563-567. PMID: 26429886; PMCID: PMC4651917.
    Citations: 89     Fields:    Translation:HumansAnimalsCells
  32. Lai CP, Kim EY, Badr CE, Weissleder R, Mempel TR, Tannous BA, Breakefield XO. Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters. Nat Commun. 2015 May 13; 6:7029. PMID: 25967391; PMCID: PMC4435621.
    Citations: 223     Fields:    Translation:HumansAnimalsCells
  33. Murooka TT, Sharaf RR, Mempel TR. Large Syncytia in Lymph Nodes Induced by CCR5-Tropic HIV-1. AIDS Res Hum Retroviruses. 2015 May; 31(5):471-2. PMID: 25835064; PMCID: PMC4426294.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  34. Shade KT, Platzer B, Washburn N, Mani V, Bartsch YC, Conroy M, Pagan JD, Bosques C, Mempel TR, Fiebiger E, Anthony RM. A single glycan on IgE is indispensable for initiation of anaphylaxis. J Exp Med. 2015 Apr 06; 212(4):457-67. PMID: 25824821; PMCID: PMC4387292.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  35. Apetoh L, Smyth MJ, Drake CG, Abastado JP, Apte RN, Ayyoub M, Blay JY, Bonneville M, Butterfield LH, Caignard A, Castelli C, Cavallo F, Celis E, Chen L, Colombo MP, Comin-Anduix B, Coukos G, Dhodapkar MV, Dranoff G, Frazer IH, Fridman WH, Gabrilovich DI, Gilboa E, Gnjatic S, Jäger D, Kalinski P, Kaufman HL, Kiessling R, Kirkwood J, Knuth A, Liblau R, Lotze MT, Lugli E, Marincola F, Melero I, Melief CJ, Mempel TR, Mittendorf EA, Odun K, Overwijk WW, Palucka AK, Parmiani G, Ribas A, Romero P, Schreiber RD, Schuler G, Srivastava PK, Tartour E, Valmori D, van der Burg SH, van der Bruggen P, van den Eynde BJ, Wang E, Zou W, Whiteside TL, Speiser DE, Pardoll DM, Restifo NP, Anderson AC. Consensus nomenclature for CD8+ T cell phenotypes in cancer. Oncoimmunology. 2015 Apr; 4(4):e998538. PMID: 26137416.
    Citations: 70     Fields:    
  36. Martinez GJ, Pereira RM, Äijö T, Kim EY, Marangoni F, Pipkin ME, Togher S, Heissmeyer V, Zhang YC, Crotty S, Lamperti ED, Ansel KM, Mempel TR, Lähdesmäki H, Hogan PG, Rao A. The transcription factor NFAT promotes exhaustion of activated CD8? T cells. Immunity. 2015 Feb 17; 42(2):265-278. PMID: 25680272; PMCID: PMC4346317.
    Citations: 265     Fields:    Translation:AnimalsCells
  37. Fackler OT, Murooka TT, Imle A, Mempel TR. Adding new dimensions: towards an integrative understanding of HIV-1 spread. Nat Rev Microbiol. 2014 Aug; 12(8):563-74. PMID: 25029025.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  38. Nery FC, Atai NA, da Hora CC, Kim EY, Hettich J, Mempel TR, Breakefield XO, Irimia D. Microfluidic platform to evaluate migration of cells from patients with DYT1 dystonia. J Neurosci Methods. 2014 Jul 30; 232:181-188. PMID: 24880044.
    Citations: 6     Fields:    Translation:HumansCells
  39. Bauer CA, Kim EY, Marangoni F, Carrizosa E, Claudio NM, Mempel TR. Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction. J Clin Invest. 2014 Jun; 124(6):2425-40. PMID: 24812664; PMCID: PMC4089459.
    Citations: 95     Fields:    Translation:AnimalsCells
  40. Guo Y, Yuan H, Claudio NM, Kura S, Shakerdge N, Mempel TR, Bacskai BJ, Josephson L. PEG-like nanoprobes: multimodal, pharmacokinetically and optically tunable nanomaterials. PLoS One. 2014; 9(4):e95406. PMID: 24781778.
    Citations: 3     Fields:    Translation:AnimalsCells
  41. Angin M, Sharma S, King M, Murooka TT, Ghebremichael M, Mempel TR, Walker BD, Bhasin MK, Addo MM. HIV-1 infection impairs regulatory T-cell suppressive capacity on a per-cell basis. J Infect Dis. 2014 Sep 15; 210(6):899-903. PMID: 24664171; PMCID: PMC4192052.
    Citations: 15     Fields:    Translation:HumansCells
  42. Lamphier M, Zheng W, Latz E, Spyvee M, Hansen H, Rose J, Genest M, Yang H, Shaffer C, Zhao Y, Shen Y, Liu C, Liu D, Mempel TR, Rowbottom C, Chow J, Twine NC, Yu M, Gusovsky F, Ishizaka ST. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar; 85(3):429-40. PMID: 24342772.
    Citations: 46     Fields:    Translation:AnimalsCells
  43. Murooka TT, Mempel TR. Intravital microscopy in BLT-humanized mice to study cellular dynamics in HIV infection. J Infect Dis. 2013 Nov; 208 Suppl 2:S137-44. PMID: 24151320; PMCID: PMC3807971.
    Citations: 11     Fields:    Translation:HumansAnimals
  44. Henrickson SE, Perro M, Loughhead SM, Senman B, Stutte S, Quigley M, Alexe G, Iannacone M, Flynn MP, Omid S, Jesneck JL, Imam S, Mempel TR, Mazo IB, Haining WN, von Andrian UH. Antigen availability determines CD8? T cell-dendritic cell interaction kinetics and memory fate decisions. Immunity. 2013 Sep 19; 39(3):496-507. PMID: 24054328.
    Citations: 64     Fields:    Translation:AnimalsCells
  45. Marangoni F, Murooka TT, Manzo T, Kim EY, Carrizosa E, Elpek NM, Mempel TR. The transcription factor NFAT exhibits signal memory during serial T cell interactions with antigen-presenting cells. Immunity. 2013 Feb 21; 38(2):237-49. PMID: 23313588.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  46. Groom JR, Richmond J, Murooka TT, Sorensen EW, Sung JH, Bankert K, von Andrian UH, Moon JJ, Mempel TR, Luster AD. CXCR3 chemokine receptor-ligand interactions in the lymph node optimize CD4+ T helper 1 cell differentiation. Immunity. 2012 Dec 14; 37(6):1091-103. PMID: 23123063.
    Citations: 181     Fields:    Translation:AnimalsCells
  47. Murooka TT, Deruaz M, Marangoni F, Vrbanac VD, Seung E, von Andrian UH, Tager AM, Luster AD, Mempel TR. HIV-infected T cells are migratory vehicles for viral dissemination. Nature. 2012 Oct 11; 490(7419):283-7. PMID: 22854780.
    Citations: 189     Fields:    Translation:HumansAnimalsCells
  48. Ignatius MS, Chen E, Elpek NM, Fuller AZ, Tenente IM, Clagg R, Liu S, Blackburn JS, Linardic CM, Rosenberg AE, Nielsen PG, Mempel TR, Langenau DM. In vivo imaging of tumor-propagating cells, regional tumor heterogeneity, and dynamic cell movements in embryonal rhabdomyosarcoma. Cancer Cell. 2012 May 15; 21(5):680-693. PMID: 22624717.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  49. Murooka TT, Mempel TR. Multiphoton intravital microscopy to study lymphocyte motility in lymph nodes. Methods Mol Biol. 2012; 757:247-57. PMID: 21909917.
    Citations: 15     Fields:    Translation:AnimalsCells
  50. Mempel TR. Single-cell analysis of cytotoxic T cell function by intravital multiphoton microscopy. Methods Mol Biol. 2010; 616:181-92. PMID: 20379876.
    Citations: 2     Fields:    Translation:AnimalsCells
  51. Barrington RA, Schneider TJ, Pitcher LA, Mempel TR, Ma M, Barteneva NS, Carroll MC. Uncoupling CD21 and CD19 of the B-cell coreceptor. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14490-5. PMID: 19706534.
    Citations: 17     Fields:    Translation:AnimalsCellsPHPublic Health
  52. Swirski FK, Nahrendorf M, Etzrodt M, Wildgruber M, Cortez-Retamozo V, Panizzi P, Figueiredo JL, Kohler RH, Chudnovskiy A, Waterman P, Aikawa E, Mempel TR, Libby P, Weissleder R, Pittet MJ. Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science. 2009 Jul 31; 325(5940):612-6. PMID: 19644120.
    Citations: 922     Fields:    Translation:AnimalsCells
  53. Gonzalez SF, Pitcher LA, Mempel T, Schuerpf F, Carroll MC. B cell acquisition of antigen in vivo. Curr Opin Immunol. 2009 Jun; 21(3):251-7. PMID: 19515546.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  54. Leimgruber A, Berger C, Cortez-Retamozo V, Etzrodt M, Newton AP, Waterman P, Figueiredo JL, Kohler RH, Elpek N, Mempel TR, Swirski FK, Nahrendorf M, Weissleder R, Pittet MJ. Behavior of endogenous tumor-associated macrophages assessed in vivo using a functionalized nanoparticle. Neoplasia. 2009 May; 11(5):459-68, 2 p following 468. PMID: 19412430.
    Citations: 54     Fields:    Translation:AnimalsCells
  55. Roozendaal R, Mempel TR, Pitcher LA, Gonzalez SF, Verschoor A, Mebius RE, von Andrian UH, Carroll MC. Conduits mediate transport of low-molecular-weight antigen to lymph node follicles. Immunity. 2009 Feb 20; 30(2):264-76. PMID: 19185517.
    Citations: 194     Fields:    Translation:AnimalsCells
  56. Mempel TR, Marangoni F. CD44 keeps tumor killers polarized. Immunity. 2008 Dec 19; 29(6):843-5. PMID: 19100697.
    Citations: 1     Fields:    Translation:AnimalsCells
  57. Sakadzic S, Demirbas U, Mempel TR, Moore A, Ruvinskaya S, Boas DA, Sennaroglu A, Kaertner FX, Fujimoto JG. Multi-photon microscopy with a low-cost and highly efficient Cr:LiCAF laser. Opt Express. 2008 Dec 08; 16(25):20848-63. PMID: 19065223.
    Citations: 11     Fields:    
  58. Bromley SK, Mempel TR, Luster AD. Orchestrating the orchestrators: chemokines in control of T cell traffic. Nat Immunol. 2008 Sep; 9(9):970-80. PMID: 18711434.
    Citations: 247     Fields:    Translation:HumansCells
  59. Mempel TR, Bauer CA. Intravital imaging of CD8+ T cell function in cancer. Clin Exp Metastasis. 2009; 26(4):311-27. PMID: 18665448.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  60. Henrickson SE, Mempel TR, Mazo IB, Liu B, Artyomov MN, Zheng H, Peixoto A, Flynn M, Senman B, Junt T, Wong HC, Chakraborty AK, von Andrian UH. In vivo imaging of T cell priming. Sci Signal. 2008 Mar 25; 1(12):pt2. PMID: 18364513.
    Citations: 21     Fields:    Translation:AnimalsCells
  61. Pittet MJ, Mempel TR. Regulation of T-cell migration and effector functions: insights from in vivo imaging studies. Immunol Rev. 2008 Feb; 221:107-29. PMID: 18275478.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  62. Henrickson SE, Mempel TR, Mazo IB, Liu B, Artyomov MN, Zheng H, Peixoto A, Flynn MP, Senman B, Junt T, Wong HC, Chakraborty AK, von Andrian UH. T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation. Nat Immunol. 2008 Mar; 9(3):282-91. PMID: 18204450.
    Citations: 208     Fields:    Translation:AnimalsCells
  63. Swirski FK, Berger CR, Figueiredo JL, Mempel TR, von Andrian UH, Pittet MJ, Weissleder R. A near-infrared cell tracker reagent for multiscopic in vivo imaging and quantification of leukocyte immune responses. PLoS One. 2007 Oct 24; 2(10):e1075. PMID: 17957257.
    Citations: 39     Fields:    Translation:AnimalsCells
  64. Junt T, Moseman EA, Iannacone M, Massberg S, Lang PA, Boes M, Fink K, Henrickson SE, Shayakhmetov DM, Di Paolo NC, van Rooijen N, Mempel TR, Whelan SP, von Andrian UH. Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature. 2007 Nov 01; 450(7166):110-4. PMID: 17934446.
    Citations: 382     Fields:    Translation:AnimalsCells
  65. Bonasio R, Carman CV, Kim E, Sage PT, Love KR, Mempel TR, Springer TA, von Andrian UH. Specific and covalent labeling of a membrane protein with organic fluorochromes and quantum dots. Proc Natl Acad Sci U S A. 2007 Sep 11; 104(37):14753-8. PMID: 17785425; PMCID: PMC1976196.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  66. Hauser AE, Junt T, Mempel TR, Sneddon MW, Kleinstein SH, Henrickson SE, von Andrian UH, Shlomchik MJ, Haberman AM. Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns. Immunity. 2007 May; 26(5):655-67. PMID: 17509908.
    Citations: 117     Fields:    Translation:AnimalsCells
  67. Worbs T, Mempel TR, Bölter J, von Andrian UH, Förster R. CCR7 ligands stimulate the intranodal motility of T lymphocytes in vivo. J Exp Med. 2007 Mar 19; 204(3):489-95. PMID: 17325198; PMCID: PMC2137901.
    Citations: 135     Fields:    Translation:AnimalsCells
  68. Nombela-Arrieta C, Mempel TR, Soriano SF, Mazo I, Wymann MP, Hirsch E, Martínez-A C, Fukui Y, von Andrian UH, Stein JV. A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress. J Exp Med. 2007 Mar 19; 204(3):497-510. PMID: 17325199; PMCID: PMC2137902.
    Citations: 58     Fields:    Translation:AnimalsCells
  69. Mempel TR, Junt T, von Andrian UH. Rulers over randomness: stroma cells guide lymphocyte migration in lymph nodes. Immunity. 2006 Dec; 25(6):867-9. PMID: 17174930.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  70. Mempel TR, Pittet MJ, Khazaie K, Weninger W, Weissleder R, von Boehmer H, von Andrian UH. Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation. Immunity. 2006 Jul; 25(1):129-41. PMID: 16860762.
    Citations: 221     Fields:    Translation:AnimalsCells
  71. Halin C, Scimone ML, Bonasio R, Gauguet JM, Mempel TR, Quackenbush E, Proia RL, Mandala S, von Andrian UH. The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches. Blood. 2005 Aug 15; 106(4):1314-22. PMID: 15870184; PMCID: PMC1895188.
    Citations: 49     Fields:    Translation:AnimalsCells
  72. Thurau SR, Mempel TR, Flügel A, Diedrichs-Möhring M, Krombach F, Kawakami N, Wildner G. The fate of autoreactive, GFP+ T cells in rat models of uveitis analyzed by intravital fluorescence microscopy and FACS. Int Immunol. 2004 Nov; 16(11):1573-82. PMID: 15351788.
    Citations: 20     Fields:    Translation:AnimalsCells
  73. Sumen C, Mempel TR, Mazo IB, von Andrian UH. Intravital microscopy: visualizing immunity in context. Immunity. 2004 Sep; 21(3):315-29. PMID: 15357943.
    Citations: 130     Fields:    Translation:HumansAnimalsCells
  74. Mempel TR, Scimone ML, Mora JR, von Andrian UH. In vivo imaging of leukocyte trafficking in blood vessels and tissues. Curr Opin Immunol. 2004 Aug; 16(4):406-17. PMID: 15245733.
    Citations: 69     Fields:    Translation:AnimalsCells
  75. Mempel TR, Henrickson SE, Von Andrian UH. T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature. 2004 Jan 08; 427(6970):154-9. PMID: 14712275.
    Citations: 701     Fields:    Translation:AnimalsCells
  76. M'Rini C, Cheng G, Schweitzer C, Cavanagh LL, Palframan RT, Mempel TR, Warnock RA, Lowe JB, Quackenbush EJ, von Andrian UH. A novel endothelial L-selectin ligand activity in lymph node medulla that is regulated by alpha(1,3)-fucosyltransferase-IV. J Exp Med. 2003 Nov 03; 198(9):1301-12. PMID: 14597733; PMCID: PMC2194247.
    Citations: 18     Fields:    Translation:AnimalsCells
  77. von Andrian UH, Mempel TR. Homing and cellular traffic in lymph nodes. Nat Rev Immunol. 2003 Nov; 3(11):867-78. PMID: 14668803.
    Citations: 459     Fields:    Translation:HumansAnimalsCells
  78. Mempel TR, Moser C, Hutter J, Kuebler WM, Krombach F. Visualization of leukocyte transendothelial and interstitial migration using reflected light oblique transillumination in intravital video microscopy. J Vasc Res. 2003 Sep-Oct; 40(5):435-41. PMID: 14530600.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  79. Till H, Metzger R, Mempel T, Boehm R, Joppich I. Proliferation, zonal maturation, and steroid production of fetal adrenal transplants in adrenalectomized rats. Pediatr Surg Int. 2000; 16(4):293-6. PMID: 10898232.
    Citations: 1     Fields:    Translation:Animals
  80. Metzger R, Mempel T, Joppich I, Till H. Organ-specific distribution of major histocompatibility antigens in rats. Pediatr Surg Int. 2000; 16(4):285-92. PMID: 10898231.
    Citations: 4     Fields:    Translation:Animals
  81. Massoudy P, Mempel T, Raschke P, Becker BF. Reduction of oxygen delivery during post-ischemic reperfusion protects the isolated guinea pig heart. Basic Res Cardiol. 1999 Aug; 94(4):231-7. PMID: 10505422.
    Citations: 2     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.