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profileThorsten Roman Mempel, Ph.D., M.D.

TitleAssociate Professor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
CIID, CNY 149, Room 8301
149 13th Street
Charlestown MA 02129
Phone617/724-4596
Fax617/726-5651
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Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R21AR070981     (MEMPEL, THORSTEN ROMAN)Aug 1, 2017 - Jul 31, 2019
NIH/NIAMS
Visualizing the signals that drive resident memory T cell formation in skin
Role: Principal Investigator

R01AI123349     (MEMPEL, THORSTEN ROMAN)Mar 1, 2017 - Feb 28, 2022
NIH/NIAID
Cellular mechanisms by which exhausted T cell responses are restored
Role: Principal Investigator

U19CA179563     (BREAKEFIELD, XANDRA OWENS)Sep 1, 2013 - Aug 31, 2018
NIH/NCI
exRNA released by glioblastoma alters brain microenvironment
Role: Co-Principal Investigator

R01AI097052     (MEMPEL, THORSTEN ROMAN)Aug 1, 2013 - Jul 31, 2017
NIH/NIAID
Migratory Properties of HIV-infected T cells in vivo
Role: Principal Investigator

R01DA036298     (GROOPMAN, JEROME E)Jul 1, 2013 - Mar 31, 2018
NIH/NIDA
Novel Strategies to Antagonize Cocaine-Enhanced HIV Pathobiology
Role: Co-Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Zhang R, Sage PT, Finn K, Huynh A, Blazar BR, Marangoni F, Mempel TR, Sharpe AH, Turka LA. B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells. J Immunol. 2017 Nov 01. PMID: 29093061.
    View in: PubMed
  2. Janssen E, Kumari S, Tohme M, Ullas S, Barrera V, Tas JM, Castillo-Rama M, Bronson RT, Usmani SM, Irvine DJ, Mempel TR, Geha RS. DOCK8 enforces immunological tolerance by promoting IL-2 signaling and immune synapse formation in Tregs. JCI Insight. 2017 Oct 05; 2(19). PMID: 28978806.
    View in: PubMed
  3. Deruaz M, Murooka TT, Ji S, Gavin MA, Vrbanac VD, Lieberman J, Tager AM, Mempel TR, Luster AD. Chemoattractant-mediated leukocyte trafficking enables HIV dissemination from the genital mucosa. JCI Insight. 2017 Apr 06; 2(7):e88533. PMID: 28405607.
    View in: PubMed
  4. Miyabe Y, Miyabe C, Murooka TT, Kim EY, Newton GA, Kim ND, Haribabu B, Luscinskas FW, Mempel TR, Luster AD. Complement C5a Receptor is the Key Initiator of Neutrophil Adhesion Igniting Immune Complex-induced Arthritis. Sci Immunol. 2017 Jan; 2(7). PMID: 28529998.
    View in: PubMed
  5. Pucci F, Garris C, Lai CP, Newton A, Pfirschke C, Engblom C, Alvarez D, Sprachman M, Evavold C, Magnuson A, von Andrian UH, Glatz K, Breakefield XO, Mempel TR, Weissleder R, Pittet MJ. SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions. Science. 2016 Apr 08; 352(6282):242-6. PMID: 26989197; PMCID: PMC4960636.
  6. Benechet AP, Menon M, Xu D, Samji T, Maher L, Murooka TT, Mempel TR, Sheridan BS, Lemoine FM, Khanna KM. T cell-intrinsic S1PR1 regulates endogenous effector T-cell egress dynamics from lymph nodes during infection. Proc Natl Acad Sci U S A. 2016 Feb 23; 113(8):2182-7. PMID: 26862175; PMCID: PMC4776484.
  7. Sharaf R, Mempel TR, Murooka TT. Visualizing the Behavior of HIV-Infected T Cells In Vivo Using Multiphoton Intravital Microscopy. Methods Mol Biol. 2016; 1354:189-201. PMID: 26714713.
    View in: PubMed
  8. Symeonides M, Murooka TT, Bellfy LN, Roy NH, Mempel TR, Thali M. HIV-1-Induced Small T Cell Syncytia Can Transfer Virus Particles to Target Cells through Transient Contacts. Viruses. 2015 Dec 12; 7(12):6590-603. PMID: 26703714; PMCID: PMC4690882.
  9. Carrizosa E, Mempel TR. Immunology: In the right place at the right time. Nature. 2015 Dec 10; 528(7581):205-6. PMID: 26605531.
    View in: PubMed
  10. van der Vos KE, Abels ER, Zhang X, Lai C, Carrizosa E, Oakley D, Prabhakar S, Mardini O, Crommentuijn MH, Skog J, Krichevsky AM, Stemmer-Rachamimov A, Mempel TR, El Khoury J, Hickman SE, Breakefield XO. Directly visualized glioblastoma-derived extracellular vesicles transfer RNA to microglia/macrophages in the brain. Neuro Oncol. 2016 Jan; 18(1):58-69. PMID: 26433199.
    View in: PubMed
  11. Sewald X, Ladinsky MS, Uchil PD, Beloor J, Pi R, Herrmann C, Motamedi N, Murooka TT, Brehm MA, Greiner DL, Shultz LD, Mempel TR, Bjorkman PJ, Kumar P, Mothes W. Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection. Science. 2015 Oct 30; 350(6260):563-567. PMID: 26429886; PMCID: PMC4651917.
  12. Lai CP, Kim EY, Badr CE, Weissleder R, Mempel TR, Tannous BA, Breakefield XO. Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters. Nat Commun. 2015 May 13; 6:7029. PMID: 25967391; PMCID: PMC4435621.
  13. Murooka TT, Sharaf RR, Mempel TR. Large Syncytia in Lymph Nodes Induced by CCR5-Tropic HIV-1. AIDS Res Hum Retroviruses. 2015 May; 31(5):471-2. PMID: 25835064; PMCID: PMC4426294.
  14. Shade KT, Platzer B, Washburn N, Mani V, Bartsch YC, Conroy M, Pagan JD, Bosques C, Mempel TR, Fiebiger E, Anthony RM. A single glycan on IgE is indispensable for initiation of anaphylaxis. J Exp Med. 2015 Apr 06; 212(4):457-67. PMID: 25824821; PMCID: PMC4387292.
  15. Apetoh L, Smyth MJ, Drake CG, Abastado JP, Apte RN, Ayyoub M, Blay JY, Bonneville M, Butterfield LH, Caignard A, Castelli C, Cavallo F, Celis E, Chen L, Colombo MP, Comin-Anduix B, Coukos G, Dhodapkar MV, Dranoff G, Frazer IH, Fridman WH, Gabrilovich DI, Gilboa E, Gnjatic S, Jäger D, Kalinski P, Kaufman HL, Kiessling R, Kirkwood J, Knuth A, Liblau R, Lotze MT, Lugli E, Marincola F, Melero I, Melief CJ, Mempel TR, Mittendorf EA, Odun K, Overwijk WW, Palucka AK, Parmiani G, Ribas A, Romero P, Schreiber RD, Schuler G, Srivastava PK, Tartour E, Valmori D, van der Burg SH, van der Bruggen P, van den Eynde BJ, Wang E, Zou W, Whiteside TL, Speiser DE, Pardoll DM, Restifo NP, Anderson AC. Consensus nomenclature for CD8+ T cell phenotypes in cancer. Oncoimmunology. 2015 Apr; 4(4):e998538. PMID: 26137416.
    View in: PubMed
  16. Martinez GJ, Pereira RM, Äijö T, Kim EY, Marangoni F, Pipkin ME, Togher S, Heissmeyer V, Zhang YC, Crotty S, Lamperti ED, Ansel KM, Mempel TR, Lähdesmäki H, Hogan PG, Rao A. The transcription factor NFAT promotes exhaustion of activated CD8? T cells. Immunity. 2015 Feb 17; 42(2):265-278. PMID: 25680272; PMCID: PMC4346317.
  17. Fackler OT, Murooka TT, Imle A, Mempel TR. Adding new dimensions: towards an integrative understanding of HIV-1 spread. Nat Rev Microbiol. 2014 Aug; 12(8):563-74. PMID: 25029025.
    View in: PubMed
  18. Nery FC, Atai NA, da Hora CC, Kim EY, Hettich J, Mempel TR, Breakefield XO, Irimia D. Microfluidic platform to evaluate migration of cells from patients with DYT1 dystonia. J Neurosci Methods. 2014 Jul 30; 232:181-188. PMID: 24880044; PMCID: PMC4120252.
  19. Bauer CA, Kim EY, Marangoni F, Carrizosa E, Claudio NM, Mempel TR. Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction. J Clin Invest. 2014 Jun; 124(6):2425-40. PMID: 24812664; PMCID: PMC4089459.
  20. Guo Y, Yuan H, Claudio NM, Kura S, Shakerdge N, Mempel TR, Bacskai BJ, Josephson L. PEG-like nanoprobes: multimodal, pharmacokinetically and optically tunable nanomaterials. PLoS One. 2014; 9(4):e95406. PMID: 24781778; PMCID: PMC4004541.
  21. Angin M, Sharma S, King M, Murooka TT, Ghebremichael M, Mempel TR, Walker BD, Bhasin MK, Addo MM. HIV-1 infection impairs regulatory T-cell suppressive capacity on a per-cell basis. J Infect Dis. 2014 Sep 15; 210(6):899-903. PMID: 24664171; PMCID: PMC4192052.
  22. Lamphier M, Zheng W, Latz E, Spyvee M, Hansen H, Rose J, Genest M, Yang H, Shaffer C, Zhao Y, Shen Y, Liu C, Liu D, Mempel TR, Rowbottom C, Chow J, Twine NC, Yu M, Gusovsky F, Ishizaka ST. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar; 85(3):429-40. PMID: 24342772.
    View in: PubMed
  23. Murooka TT, Mempel TR. Intravital microscopy in BLT-humanized mice to study cellular dynamics in HIV infection. J Infect Dis. 2013 Nov; 208 Suppl 2:S137-44. PMID: 24151320; PMCID: PMC3807971.
  24. Henrickson SE, Perro M, Loughhead SM, Senman B, Stutte S, Quigley M, Alexe G, Iannacone M, Flynn MP, Omid S, Jesneck JL, Imam S, Mempel TR, Mazo IB, Haining WN, von Andrian UH. Antigen availability determines CD8? T cell-dendritic cell interaction kinetics and memory fate decisions. Immunity. 2013 Sep 19; 39(3):496-507. PMID: 24054328; PMCID: PMC3914670.
  25. Marangoni F, Murooka TT, Manzo T, Kim EY, Carrizosa E, Elpek NM, Mempel TR. The transcription factor NFAT exhibits signal memory during serial T cell interactions with antigen-presenting cells. Immunity. 2013 Feb 21; 38(2):237-49. PMID: 23313588; PMCID: PMC3582823.
  26. Groom JR, Richmond J, Murooka TT, Sorensen EW, Sung JH, Bankert K, von Andrian UH, Moon JJ, Mempel TR, Luster AD. CXCR3 chemokine receptor-ligand interactions in the lymph node optimize CD4+ T helper 1 cell differentiation. Immunity. 2012 Dec 14; 37(6):1091-103. PMID: 23123063; PMCID: PMC3525757.
  27. Murooka TT, Deruaz M, Marangoni F, Vrbanac VD, Seung E, von Andrian UH, Tager AM, Luster AD, Mempel TR. HIV-infected T cells are migratory vehicles for viral dissemination. Nature. 2012 Oct 11; 490(7419):283-7. PMID: 22854780; PMCID: PMC3470742.
  28. Ignatius MS, Chen E, Elpek NM, Fuller AZ, Tenente IM, Clagg R, Liu S, Blackburn JS, Linardic CM, Rosenberg AE, Nielsen PG, Mempel TR, Langenau DM. In vivo imaging of tumor-propagating cells, regional tumor heterogeneity, and dynamic cell movements in embryonal rhabdomyosarcoma. Cancer Cell. 2012 May 15; 21(5):680-93. PMID: 22624717; PMCID: PMC3381357.
  29. Murooka TT, Mempel TR. Multiphoton intravital microscopy to study lymphocyte motility in lymph nodes. Methods Mol Biol. 2012; 757:247-57. PMID: 21909917.
    View in: PubMed
  30. Mempel TR. Single-cell analysis of cytotoxic T cell function by intravital multiphoton microscopy. Methods Mol Biol. 2010; 616:181-92. PMID: 20379876.
    View in: PubMed
  31. Barrington RA, Schneider TJ, Pitcher LA, Mempel TR, Ma M, Barteneva NS, Carroll MC. Uncoupling CD21 and CD19 of the B-cell coreceptor. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14490-5. PMID: 19706534; PMCID: PMC2732852.
  32. Swirski FK, Nahrendorf M, Etzrodt M, Wildgruber M, Cortez-Retamozo V, Panizzi P, Figueiredo JL, Kohler RH, Chudnovskiy A, Waterman P, Aikawa E, Mempel TR, Libby P, Weissleder R, Pittet MJ. Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science. 2009 Jul 31; 325(5940):612-6. PMID: 19644120; PMCID: PMC2803111.
  33. Gonzalez SF, Pitcher LA, Mempel T, Schuerpf F, Carroll MC. B cell acquisition of antigen in vivo. Curr Opin Immunol. 2009 Jun; 21(3):251-7. PMID: 19515546; PMCID: PMC2717615.
  34. Leimgruber A, Berger C, Cortez-Retamozo V, Etzrodt M, Newton AP, Waterman P, Figueiredo JL, Kohler RH, Elpek N, Mempel TR, Swirski FK, Nahrendorf M, Weissleder R, Pittet MJ. Behavior of endogenous tumor-associated macrophages assessed in vivo using a functionalized nanoparticle. Neoplasia. 2009 May; 11(5):459-68, 2 p following 468. PMID: 19412430; PMCID: PMC2672160.
  35. Roozendaal R, Mempel TR, Pitcher LA, Gonzalez SF, Verschoor A, Mebius RE, von Andrian UH, Carroll MC. Conduits mediate transport of low-molecular-weight antigen to lymph node follicles. Immunity. 2009 Feb 20; 30(2):264-76. PMID: 19185517; PMCID: PMC2699624.
  36. Mempel TR, Marangoni F. CD44 keeps tumor killers polarized. Immunity. 2008 Dec 19; 29(6):843-5. PMID: 19100697.
    View in: PubMed
  37. Sakadzic S, Demirbas U, Mempel TR, Moore A, Ruvinskaya S, Boas DA, Sennaroglu A, Kaertner FX, Fujimoto JG. Multi-photon microscopy with a low-cost and highly efficient Cr:LiCAF laser. Opt Express. 2008 Dec 08; 16(25):20848-63. PMID: 19065223; PMCID: PMC2689708.
  38. Bromley SK, Mempel TR, Luster AD. Orchestrating the orchestrators: chemokines in control of T cell traffic. Nat Immunol. 2008 Sep; 9(9):970-80. PMID: 18711434.
    View in: PubMed
  39. Mempel TR, Bauer CA. Intravital imaging of CD8+ T cell function in cancer. Clin Exp Metastasis. 2009; 26(4):311-27. PMID: 18665448; PMCID: PMC3747036.
  40. Henrickson SE, Mempel TR, Mazo IB, Liu B, Artyomov MN, Zheng H, Peixoto A, Flynn M, Senman B, Junt T, Wong HC, Chakraborty AK, von Andrian UH. In vivo imaging of T cell priming. Sci Signal. 2008 Mar 25; 1(12):pt2. PMID: 18364513.
    View in: PubMed
  41. Pittet MJ, Mempel TR. Regulation of T-cell migration and effector functions: insights from in vivo imaging studies. Immunol Rev. 2008 Feb; 221:107-29. PMID: 18275478.
    View in: PubMed
  42. Henrickson SE, Mempel TR, Mazo IB, Liu B, Artyomov MN, Zheng H, Peixoto A, Flynn MP, Senman B, Junt T, Wong HC, Chakraborty AK, von Andrian UH. T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation. Nat Immunol. 2008 Mar; 9(3):282-91. PMID: 18204450; PMCID: PMC2698867.
  43. Swirski FK, Berger CR, Figueiredo JL, Mempel TR, von Andrian UH, Pittet MJ, Weissleder R. A near-infrared cell tracker reagent for multiscopic in vivo imaging and quantification of leukocyte immune responses. PLoS One. 2007 Oct 24; 2(10):e1075. PMID: 17957257; PMCID: PMC2034600.
  44. Junt T, Moseman EA, Iannacone M, Massberg S, Lang PA, Boes M, Fink K, Henrickson SE, Shayakhmetov DM, Di Paolo NC, van Rooijen N, Mempel TR, Whelan SP, von Andrian UH. Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature. 2007 Nov 01; 450(7166):110-4. PMID: 17934446.
    View in: PubMed
  45. Bonasio R, Carman CV, Kim E, Sage PT, Love KR, Mempel TR, Springer TA, von Andrian UH. Specific and covalent labeling of a membrane protein with organic fluorochromes and quantum dots. Proc Natl Acad Sci U S A. 2007 Sep 11; 104(37):14753-8. PMID: 17785425; PMCID: PMC1976196.
  46. Hauser AE, Junt T, Mempel TR, Sneddon MW, Kleinstein SH, Henrickson SE, von Andrian UH, Shlomchik MJ, Haberman AM. Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns. Immunity. 2007 May; 26(5):655-67. PMID: 17509908.
    View in: PubMed
  47. Worbs T, Mempel TR, Bölter J, von Andrian UH, Förster R. CCR7 ligands stimulate the intranodal motility of T lymphocytes in vivo. J Exp Med. 2007 Mar 19; 204(3):489-95. PMID: 17325198; PMCID: PMC2137901.
  48. Nombela-Arrieta C, Mempel TR, Soriano SF, Mazo I, Wymann MP, Hirsch E, Martínez-A C, Fukui Y, von Andrian UH, Stein JV. A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress. J Exp Med. 2007 Mar 19; 204(3):497-510. PMID: 17325199; PMCID: PMC2137902.
  49. Mempel TR, Junt T, von Andrian UH. Rulers over randomness: stroma cells guide lymphocyte migration in lymph nodes. Immunity. 2006 Dec; 25(6):867-9. PMID: 17174930.
    View in: PubMed
  50. Mempel TR, Pittet MJ, Khazaie K, Weninger W, Weissleder R, von Boehmer H, von Andrian UH. Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation. Immunity. 2006 Jul; 25(1):129-41. PMID: 16860762.
    View in: PubMed
  51. Halin C, Scimone ML, Bonasio R, Gauguet JM, Mempel TR, Quackenbush E, Proia RL, Mandala S, von Andrian UH. The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches. Blood. 2005 Aug 15; 106(4):1314-22. PMID: 15870184; PMCID: PMC1895188.
  52. Thurau SR, Mempel TR, Flügel A, Diedrichs-Möhring M, Krombach F, Kawakami N, Wildner G. The fate of autoreactive, GFP+ T cells in rat models of uveitis analyzed by intravital fluorescence microscopy and FACS. Int Immunol. 2004 Nov; 16(11):1573-82. PMID: 15351788.
    View in: PubMed
  53. Sumen C, Mempel TR, Mazo IB, von Andrian UH. Intravital microscopy: visualizing immunity in context. Immunity. 2004 Sep; 21(3):315-29. PMID: 15357943.
    View in: PubMed
  54. Mempel TR, Scimone ML, Mora JR, von Andrian UH. In vivo imaging of leukocyte trafficking in blood vessels and tissues. Curr Opin Immunol. 2004 Aug; 16(4):406-17. PMID: 15245733.
    View in: PubMed
  55. Mempel TR, Henrickson SE, Von Andrian UH. T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature. 2004 Jan 08; 427(6970):154-9. PMID: 14712275.
    View in: PubMed
  56. M'Rini C, Cheng G, Schweitzer C, Cavanagh LL, Palframan RT, Mempel TR, Warnock RA, Lowe JB, Quackenbush EJ, von Andrian UH. A novel endothelial L-selectin ligand activity in lymph node medulla that is regulated by alpha(1,3)-fucosyltransferase-IV. J Exp Med. 2003 Nov 03; 198(9):1301-12. PMID: 14597733; PMCID: PMC2194247.
  57. von Andrian UH, Mempel TR. Homing and cellular traffic in lymph nodes. Nat Rev Immunol. 2003 Nov; 3(11):867-78. PMID: 14668803.
    View in: PubMed
  58. Mempel TR, Moser C, Hutter J, Kuebler WM, Krombach F. Visualization of leukocyte transendothelial and interstitial migration using reflected light oblique transillumination in intravital video microscopy. J Vasc Res. 2003 Sep-Oct; 40(5):435-41. PMID: 14530600.
    View in: PubMed
  59. Till H, Metzger R, Mempel T, Boehm R, Joppich I. Proliferation, zonal maturation, and steroid production of fetal adrenal transplants in adrenalectomized rats. Pediatr Surg Int. 2000; 16(4):293-6. PMID: 10898232.
    View in: PubMed
  60. Metzger R, Mempel T, Joppich I, Till H. Organ-specific distribution of major histocompatibility antigens in rats. Pediatr Surg Int. 2000; 16(4):285-92. PMID: 10898231.
    View in: PubMed
  61. Massoudy P, Mempel T, Raschke P, Becker BF. Reduction of oxygen delivery during post-ischemic reperfusion protects the isolated guinea pig heart. Basic Res Cardiol. 1999 Aug; 94(4):231-7. PMID: 10505422.
    View in: PubMed
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