An elaborate neural network integrating internal and external signals governs the onset of puberty and subsequent fertility. The precise nature and components of this network are not well established, but it is clear that puberty is triggered by the central increase in pulsatile gonadotropin-releasing hormone (GnRH) secretion, which stimulates the secretion of the pituitary gonadotropins, necessary for the activation of gonadal function. Our laboratory uses a translational approach to study the hormones and genes involved in the neuroendocrine regulation of reproductive development, puberty onset and subsequent fertility.
Our approaches include studies of:
Potential Student Roles:
The aim of our research is to elucidate the molecular and biological underpinnings of reproductive disorders, including central precocious puberty, hypothalamic amenorrhea, polycystic ovarian syndrome and infertility, using clinical and laboratory observations in humans, investigations in mouse models, and in vitro studies including human pluripotent stem cells and other cell models. Basic laboratory skills and an interest in endocrinology are helpful.
Potential student roles include: