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Ursula Brigitte Kaiser, M.D.

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Mentoring
Available: 01/04/23, Expires: 12/31/24

Our goals are to elucidate the molecular and biological underpinnings of reproductive disorders, including central precocious puberty, hypothalamic amenorrhea, polycystic ovarian syndrome and infertility, using clinical, genetic and laboratory observations and findings in humans, investigations in mouse models, and in vitro studies, including human pluripotent stem cells and other cell models. Basic laboratory skills and an interest in endocrinology are helpful. Our approaches include studies of: 1. Human inducible pluripotent stem cell models of hypothalamic neurons and pituitary cells. 2. In vitro studies using cellular, molecular, and proteomic approaches. 3. In vivo mouse models. 4. Human studies of patients with clinical neuroendocrine and reproductive endocrine disorders. Potential Student Roles: 1. Assist with reproductive phenotyping of genetically modified mouse models (e.g., pubertal markers, estrous cyclicity). 2. Assist with human genetic studies, including review of human subject clinical data to correlate genetic findings with clinical phenotypes, DNA sequencing and sequence analysis, and analyses of exome and genome sequence data. 3. Contribute to laboratory studies using human inducible pluripotent stem cell (hiPSC)-derived hypothalamic neurons. 4. Assist with other in vitro molecular and proteomic studies using immortalized cell lines.

Gonadatropin Gene Expression; Reproductive Endocrinology
Summer, 06/08/00 - 08/26/00

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21HD098684 (KAISER, URSULA B.) Apr 1, 2020 - Mar 31, 2022
    NIH
    Integrated analysis of genetic and epigenetic variants in central precocious puberty
    Role: Principal Investigator
  2. R01HD082314 (KAISER, URSULA B.) Apr 1, 2015 - Jun 30, 2027
    NIH
    Deciphering the functional role of MKRN3 in puberty and reproduction
    Role: Principal Investigator
  3. R21HD066495 (KAISER, URSULA B) Sep 15, 2010 - Aug 31, 2013
    NIH
    The Epigenetic Regulation of Puberty
    Role: Principal Investigator
  4. R01HD061577 (KAISER, URSULA B) Sep 1, 2009 - Aug 31, 2012
    NIH
    Use of Gene Therapy: A Tool to Study Reproductive Function
    Role: Principal Investigator
  5. R21HD050412 (KAISER, URSULA B) Aug 1, 2005 - Jul 31, 2008
    NIH
    GENE THERAPY FOR RESCUE OF REPRODUCTIVE FUNCTION
    Role: Principal Investigator

Bibliographic
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.