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Ursula Brigitte Kaiser, M.D.

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Mentoring
Available: 10/01/19, Expires: 09/30/21

An elaborate neural network integrating internal and external signals governs the onset of puberty and subsequent fertility. The precise nature and components of this network are not well established, but it is clear that puberty is triggered by the central increase in pulsatile gonadotropin-releasing hormone (GnRH) secretion, which stimulates the secretion of the pituitary gonadotropins, necessary for the activation of gonadal function. Our laboratory uses a translational approach to study the hormones and genes involved in the neuroendocrine regulation of reproductive development, puberty onset and subsequent fertility.

Our approaches include studies of:

  1. Hypothalamic and pituitary cell models and in vitro studies;
  2. In vivo mouse models; and
  3. Patients with clinical reproductive disorders.

Potential Student Roles:

  1. Assist with reproductive phenotyping of genetically modified mouse models (e.g., pubertal markers, estrous cyclicity);
  2. Assist with human genetic studies, including review of human patient clinical data to correlate with genetic findings with clinical phenotypes, and DNA sequencing and sequence analysis, including analyses of exome sequence data;
  3. Contribute to laboratory studies of human inducible pluripotent stem cell (hiPSC)-derived hypothalamic neurons that have been genetically modified by CRISPR-Cas9.

Available: 12/01/20, Expires: 12/31/21

The aim of our research is to elucidate the molecular and biological underpinnings of reproductive disorders, including central precocious puberty, hypothalamic amenorrhea, polycystic ovarian syndrome and infertility, using clinical and laboratory observations in humans, investigations in mouse models, and in vitro studies including human pluripotent stem cells and other cell models. Basic laboratory skills and an interest in endocrinology are helpful.

Our approaches include studies of:

  1. Hypothalamic, pituitary and human inducible pluripotent stem cell models.
  2. In vivo mouse models.
  3. Patients with clinical neuroendocrine and reproductive endocrine disorders.

Potential student roles include:

  1. Assist with reproductive phenotyping of genetically modified mouse models (e.g., pubertal markers, estrous cyclicity).
  2. Assist with human genetic studies, including review of human subject clinical data to correlate genetic findings with clinical phenotypes, as well as DNA sequencing and sequence analysis, including analyses of exome and genome sequence data
  3. Contribute to laboratory studies using human inducible pluripotent stem cell (hiPSC)-derived hypothalamic neurons that have been genetically modified by CRISPR-Cas9.

Gonadatropin Gene Expression; Reproductive Endocrinology
Summer, 06/08/00 - 08/26/00

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21HD098684 (KAISER, URSULA B.) Apr 1, 2020 - Mar 31, 2022
    NIH
    Integrated analysis of genetic and epigenetic variants in central precocious puberty
    Role: Principal Investigator
  2. R01HD082314 (KAISER, URSULA B.) Apr 1, 2015 - Jan 31, 2021
    NIH
    Deciphering the functional role of MKRN3 in puberty and reproduction
    Role: Principal Investigator
  3. R21HD066495 (KAISER, URSULA B) Sep 15, 2010 - Aug 31, 2013
    NIH
    The Epigenetic Regulation of Puberty
    Role: Principal Investigator
  4. R01HD061577 (KAISER, URSULA B) Sep 1, 2009 - Aug 31, 2012
    NIH
    Use of Gene Therapy: A Tool to Study Reproductive Function
    Role: Principal Investigator
  5. R01HD019938 (KAISER, URSULA B.) Jun 19, 2009 - Dec 31, 2003
    NIH
    Reproductive Physiology of Gonadotropin Synthesis
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Maione L, Bouvattier C, Kaiser UB. Central precocious puberty: recent advances in understanding the etiology and in the clinical approach. Clin Endocrinol (Oxf). 2021 Apr 02. PMID: 33797780.
    Citations:    Fields:    
  2. Seraphim CE, Canton APM, Montenegro L, Piovesan MR, Macedo DB, Cunha M, Guimaraes A, Ramos CO, Benedetti AFF, de Castro Leal A, Gagliardi PC, Antonini SR, Gryngarten M, Arcari AJ, Abreu AP, Kaiser UB, Soriano-Guillén L, Escribano-Muñoz A, Corripio R, Labarta JI, Travieso-Suárez L, Ortiz-Cabrera NV, Argente J, Mendonca BB, Brito VN, Latronico AC. Genotype-Phenotype Correlations in Central Precocious Puberty Caused by MKRN3 Mutations. J Clin Endocrinol Metab. 2021 Mar 25; 106(4):1041-1050. PMID: 33383582.
    Citations:    Fields:    
  3. Cote DJ, Smith TR, Kaiser UB, Laws ER, Stampfer MJ. Body Habitus Across the Lifespan and Risk of Pituitary Adenoma. J Clin Endocrinol Metab. 2021 Mar 25; 106(4):e1591-e1602. PMID: 33417714.
    Citations: 1     Fields:    
  4. de Wit AE, Giltay EJ, de Boer MK, Bosker FJ, Cohn AY, Nolen WA, Kaiser UB, Joffe H, Penninx BWJH, Schoevers RA. Plasma androgens and the presence and course of depression in a large cohort of women. Transl Psychiatry. 2021 Feb 12; 11(1):124. PMID: 33579903.
    Citations:    Fields:    
  5. Ho K, Fleseriu M, Kaiser U, Salvatori R, Brue T, Lopes MB, Kunz P, Molitch M, Camper SA, Gadelha M, Syro LV, Laws E, Reincke M, Nishioka H, Grossman A, Barkan A, Casanueva F, Wass J, Mamelak A, Katznelson L, van der Lely AJ, Radovick S, Bidlingmaier M, Boguszewski M, Bollerslev J, Hoffman AR, Oyesiku N, Raverot G, Ben-Shlomo A, Fowkes R, Shimon I, Fukuoka H, Pereira AM, Greenman Y, Heaney AP, Gurnell M, Johannsson G, Osamura RY, Buchfelder M, Zatelli MC, Korbonits M, Chanson P, Biermasz N, Clemmons DR, Karavitaki N, Bronstein MD, Trainer P, Melmed S. Pituitary Neoplasm Nomenclature Workshop: Does Adenoma Stand the Test of Time? J Endocr Soc. 2021 Mar 01; 5(3):bvaa205. PMID: 33604494.
    Citations:    
  6. Naulé L, Maione L, Kaiser UB. Puberty, A Sensitive Window of Hypothalamic Development and Plasticity. Endocrinology. 2021 Jan 01; 162(1). PMID: 33513610.
    Citations:    Fields:    
  7. Naulé L, Maione L, Kaiser UB. Puberty, A Sensitive Window of Hypothalamic Development and Plasticity. Endocrinology. 2021 Jan 01; 162(1). PMID: 33513611.
    Citations:    Fields:    
  8. Wang F, Catalino MP, Bi WL, Dunn IF, Smith TR, Guo Y, Hordejuk D, Kaiser UB, Laws ER, Min L. Postoperative Day 1 Morning Cortisol Value as a Biomarker to Predict Long-term Remission of Cushing Disease. J Clin Endocrinol Metab. 2021 Jan 01; 106(1):e94-e102. PMID: 33108450.
    Citations:    Fields:    
  9. Naulé L, Maione L, Kaiser UB. Puberty, A Sensitive Window of Hypothalamic Development and Plasticity. Endocrinology. 2021 01 01; 162(1). PMID: 33175140.
    Citations: 1     Fields:    
  10. Roberts SA, Kaiser UB. GENETICS IN ENDOCRINOLOGY: Genetic etiologies of central precocious puberty and the role of imprinted genes. Eur J Endocrinol. 2020 Oct; 183(4):R107-R117. PMID: 32698138.
    Citations: 1     Fields:    Translation:Humans
  11. Westfield G, Kaiser UB, Lamb DJ, Ramasamy R. Short-Acting Testosterone: More Physiologic? Front Endocrinol (Lausanne). 2020; 11:572465. PMID: 33117287.
    Citations:    
  12. Dichtel LE, Kimball A, Yuen KCJ, Woodmansee W, Haines MS, Guan QX, Swearingen B, Nachtigall LB, Tritos NA, Sharpless JL, Kaiser UB, Gerweck AV, Miller KK. Effects of growth hormone receptor antagonism and somatostatin analog administration on quality of life in acromegaly. Clin Endocrinol (Oxf). 2021 Jan; 94(1):58-65. PMID: 32779234.
    Citations:    Fields:    
  13. Maione L, Naulé L, Kaiser UB. Makorin RING finger protein 3 and central precocious puberty. Curr Opin Endocr Metab Res. 2020 Oct; 14:152-159. PMID: 32984644.
    Citations:    
  14. Abreu AP, Toro CA, Song YB, Navarro VM, Bosch MA, Eren A, Liang JN, Carroll RS, Latronico AC, Rønnekleiv OK, Aylwin CF, Lomniczi A, Ojeda S, Kaiser UB. MKRN3 inhibits the reproductive axis through actions in kisspeptin-expressing neurons. J Clin Invest. 2020 08 03; 130(8):4486-4500. PMID: 32407292.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  15. Ramasamy R, Masterson TA, Best JC, Bitran J, Ibrahim E, Molina M, Kaiser UB, Miao F, Reis IM. Reply by Authors. J Urol. 2020 09; 204(3):563. PMID: 32574104.
    Citations:    Fields:    
  16. Roberts SA, Abreu AP, Navarro VM, Liang JN, Maguire CA, Kim HK, Carroll RS, Kaiser UB. The Peripubertal Decline in Makorin Ring Finger Protein 3 Expression is Independent of Leptin Action. J Endocr Soc. 2020 Jul 01; 4(7):bvaa059. PMID: 32587933.
    Citations: 2     
  17. Kaiser UB, Mirmira RG, Stewart PM. Our Response to COVID-19 as Endocrinologists and Diabetologists. J Clin Endocrinol Metab. 2020 05 01; 105(5). PMID: 32232480.
    Citations: 28     Fields:    Translation:HumansPHPublic Health
  18. Ramasamy R, Masterson TA, Best JC, Bitran J, Ibrahim E, Molina M, Kaiser UB, Miao F, Reis IM. Effect of Natesto on Reproductive Hormones, Semen Parameters and Hypogonadal Symptoms: A Single Center, Open Label, Single Arm Trial. J Urol. 2020 09; 204(3):557-563. PMID: 32294396.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  19. Bartz D, Chitnis T, Kaiser UB, Rich-Edwards JW, Rexrode KM, Pennell PB, Goldstein JM, O'Neal MA, LeBoff M, Behn M, Seely EW, Joffe H, Manson JE. Clinical Advances in Sex- and Gender-Informed Medicine to Improve the Health of All: A Review. JAMA Intern Med. 2020 04 01; 180(4):574-583. PMID: 32040165.
    Citations: 13     Fields:    Translation:Humans
  20. Naulé L, Kaiser UB. Evolutionary Conservation of MKRN3 and Other Makorins and Their Roles in Puberty Initiation and Endocrine Functions. Semin Reprod Med. 2019 07; 37(4):166-173. PMID: 31972861.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  21. Macedo DB, Kaiser UB. DLK1, Notch Signaling and the Timing of Puberty. Semin Reprod Med. 2019 07; 37(4):174-181. PMID: 31972862.
    Citations: 1     Fields:    Translation:HumansCells
  22. Heras V, Sangiao-Alvarellos S, Manfredi-Lozano M, Sanchez-Tapia MJ, Ruiz-Pino F, Roa J, Lara-Chica M, Morrugares-Carmona R, Jouy N, Abreu AP, Prevot V, Belsham D, Vazquez MJ, Calzado MA, Pinilla L, Gaytan F, Latronico AC, Kaiser UB, Castellano JM, Tena-Sempere M. Hypothalamic miR-30 regulates puberty onset via repression of the puberty-suppressing factor, Mkrn3. PLoS Biol. 2019 11; 17(11):e3000532. PMID: 31697675.
    Citations: 8     Fields:    Translation:AnimalsCells
  23. Clark EA, Wu F, Chen Y, Kang P, Kaiser UB, Fang R, Shi YG. GR and LSD1/KDM1A-Targeted Gene Activation Requires Selective H3K4me2 Demethylation at Enhancers. Cell Rep. 2019 06 18; 27(12):3522-3532.e3. PMID: 31216473.
    Citations: 3     Fields:    Translation:HumansCells
  24. Ma C, Hodi FS, Giobbie-Hurder A, Wang X, Zhou J, Zhang A, Zhou Y, Mao F, Angell TE, Andrews CP, Hu J, Barroso-Sousa R, Kaiser UB, Tolaney SM, Min L. The Impact of High-Dose Glucocorticoids on the Outcome of Immune-Checkpoint Inhibitor-Related Thyroid Disorders. Cancer Immunol Res. 2019 07; 7(7):1214-1220. PMID: 31088848.
    Citations: 3     Fields:    Translation:Humans
  25. Lee JA, Kuchakulla M, Arora H, Kulandavelu S, Gonzalez E, Masterson TA, Hare JM, Kaiser UB, Ramasamy R. Age Induced Nitroso-Redox Imbalance Leads to Subclinical Hypogonadism in Male Mice. Front Endocrinol (Lausanne). 2019; 10:190. PMID: 30984111.
    Citations: 1     
  26. Valadares LP, Meireles CG, De Toledo IP, Santarem de Oliveira R, Gonçalves de Castro LC, Abreu AP, Carroll RS, Latronico AC, Kaiser UB, Guerra ENS, Lofrano-Porto A. MKRN3 Mutations in Central Precocious Puberty: A Systematic Review and Meta-Analysis. J Endocr Soc. 2019 May 01; 3(5):979-995. PMID: 31041429.
    Citations: 12     
  27. Chang LS, Barroso-Sousa R, Tolaney SM, Hodi FS, Kaiser UB, Min L. Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints. Endocr Rev. 2019 02 01; 40(1):17-65. PMID: 30184160.
    Citations: 40     Fields:    Translation:Humans
  28. Stamatiades GA, Carroll RS, Kaiser UB. GnRH-A Key Regulator of FSH. Endocrinology. 2019 01 01; 160(1):57-67. PMID: 30517625.
    Citations: 6     Fields:    Translation:HumansAnimals
  29. Garrel G, Denoyelle C, L'Hôte D, Picard JY, Teixeira J, Kaiser UB, Laverrière JN, Cohen-Tannoudji J. GnRH Transactivates Human AMH Receptor Gene via Egr1 and FOXO1 in Gonadotrope Cells. Neuroendocrinology. 2019; 108(2):65-83. PMID: 30368511.
    Citations: 5     Fields:    Translation:AnimalsCells
  30. Rich-Edwards JW, Kaiser UB, Chen GL, Manson JE, Goldstein JM. Sex and Gender Differences Research Design for Basic, Clinical, and Population Studies: Essentials for Investigators. Endocr Rev. 2018 08 01; 39(4):424-439. PMID: 29668873.
    Citations: 18     Fields:    Translation:Humans
  31. Ross RA, Leon S, Madara JC, Schafer D, Fergani C, Maguire CA, Verstegen AM, Brengle E, Kong D, Herbison AE, Kaiser UB, Lowell BB, Navarro VM. PACAP neurons in the ventral premammillary nucleus regulate reproductive function in the female mouse. Elife. 2018 06 15; 7. PMID: 29905528.
    Citations: 14     Fields:    Translation:AnimalsCells
  32. Macedo DB, França MM, Montenegro LR, Cunha-Silva M, Best DS, Abreu AP, Kaiser UB, Mendonca BB, Jorge AAL, Brito VN, Latronico AC. Central Precocious Puberty Caused by a Heterozygous Deletion in the MKRN3 Promoter Region. Neuroendocrinology. 2018; 107(2):127-132. PMID: 29763903.
    Citations: 7     Fields:    Translation:HumansCells
  33. Masterson TA, Arora H, Kulandavelu S, Carroll RS, Kaiser UB, Gultekin SH, Hare JM, Ramasamy R. S-Nitrosoglutathione Reductase (GSNOR) Deficiency Results in Secondary Hypogonadism. J Sex Med. 2018 05; 15(5):654-661. PMID: 29606625.
    Citations: 3     Fields:    Translation:Animals
  34. Barroso-Sousa R, Ott PA, Hodi FS, Kaiser UB, Tolaney SM, Min L. Endocrine dysfunction induced by immune checkpoint inhibitors: Practical recommendations for diagnosis and clinical management. Cancer. 2018 03 15; 124(6):1111-1121. PMID: 29313945.
    Citations: 16     Fields:    Translation:Humans
  35. Neustadt K, Deckert S, Kopkow C, Preißler A, Bosse B, Funke C, Jacobi L, Mattenklodt P, Nagel B, Seidel P, Sittl R, Steffen E, Sabatowski R, Schmitt J, Kaiser U. [What does pain intensity mean from the patient perspective? : A qualitative study on the patient perspective of pain intensity as an outcome parameter in treatment evaluation and on the interpretability of pain intensity measurements]. Schmerz. 2017 Dec; 31(6):580-593. PMID: 28660417.
    Citations:    Fields:    Translation:Humans
  36. Stamatiades GA, Kaiser UB. Gonadotropin regulation by pulsatile GnRH: Signaling and gene expression. Mol Cell Endocrinol. 2018 03 05; 463:131-141. PMID: 29102564.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  37. Mao JF, Liu ZX, Nie M, Wang X, Xu HL, Huang BK, Zheng JJ, Min L, Kaiser UB, Wu XY. Pulsatile gonadotropin-releasing hormone therapy is associated with earlier spermatogenesis compared to combined gonadotropin therapy in patients with congenital hypogonadotropic hypogonadism. Asian J Androl. 2017 Nov-Dec; 19(6):680-685. PMID: 28051040.
    Citations: 6     Fields:    Translation:Humans
  38. Lee H, Hodi FS, Giobbie-Hurder A, Ott PA, Buchbinder EI, Haq R, Tolaney S, Barroso-Sousa R, Zhang K, Donahue H, Davis M, Gargano ME, Kelley KM, Carroll RS, Kaiser UB, Min L. Characterization of Thyroid Disorders in Patients Receiving Immune Checkpoint Inhibition Therapy. Cancer Immunol Res. 2017 12; 5(12):1133-1140. PMID: 29079654.
    Citations: 21     Fields:    Translation:HumansCells
  39. Stoppiello CT, Biskupek J, Li ZY, Rance GA, Botos A, Fogarty RM, Bourne RA, Yuan J, Lovelock KRJ, Thompson P, Fay MW, Kaiser U, Chamberlain TW, Khlobystov AN. A one-pot-one-reactant synthesis of platinum compounds at the nanoscale. Nanoscale. 2017 Oct 05; 9(38):14385-14394. PMID: 28948268.
    Citations: 2     Fields:    
  40. Maguire CA, León S, Carroll RS, Kaiser UB, Navarro VM. Altered circadian feeding behavior and improvement of metabolic syndrome in obese Tac1-deficient mice. Int J Obes (Lond). 2017 Dec; 41(12):1798-1804. PMID: 28775376.
    Citations: 2     Fields:    Translation:AnimalsCells
  41. Maguire CA, Song YB, Wu M, León S, Carroll RS, Alreja M, Kaiser UB, Navarro VM. Tac1 Signaling Is Required for Sexual Maturation and Responsiveness of GnRH Neurons to Kisspeptin in the Male Mouse. Endocrinology. 2017 07 01; 158(7):2319-2329. PMID: 28444173.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  42. Zheng J, Mao J, Xu H, Wang X, Huang B, Liu Z, Cui M, Xiong S, Ma W, Min L, Kaiser UB, Nie M, Wu X. Pulsatile GnRH Therapy May Restore Hypothalamus-Pituitary-Testis Axis Function in Patients With Congenital Combined Pituitary Hormone Deficiency: A Prospective, Self-Controlled Trial. J Clin Endocrinol Metab. 2017 07 01; 102(7):2291-2300. PMID: 28368486.
    Citations: 5     Fields:    Translation:Humans
  43. Bi WL, Greenwald NF, Ramkissoon SH, Abedalthagafi M, Coy SM, Ligon KL, Mei Y, MacConaill L, Ducar M, Min L, Santagata S, Kaiser UB, Beroukhim R, Laws ER, Dunn IF. Clinical Identification of Oncogenic Drivers and Copy-Number Alterations in Pituitary Tumors. Endocrinology. 2017 07 01; 158(7):2284-2291. PMID: 28486603.
    Citations: 17     Fields:    Translation:HumansCells
  44. Dauber A, Cunha-Silva M, Macedo DB, Brito VN, Abreu AP, Roberts SA, Montenegro LR, Andrew M, Kirby A, Weirauch MT, Labilloy G, Bessa DS, Carroll RS, Jacobs DC, Chappell PE, Mendonca BB, Haig D, Kaiser UB, Latronico AC. Paternally Inherited DLK1 Deletion Associated With Familial Central Precocious Puberty. J Clin Endocrinol Metab. 2017 05 01; 102(5):1557-1567. PMID: 28324015.
    Citations: 21     Fields:    Translation:Humans
  45. Ercan A, Kohrt WM, Cui J, Deane KD, Pezer M, Yu EW, Hausmann JS, Campbell H, Kaiser UB, Rudd PM, Lauc G, Wilson JF, Finkelstein JS, Nigrovic PA. Estrogens regulate glycosylation of IgG in women and men. JCI Insight. 2017 02 23; 2(4):e89703. PMID: 28239652.
    Citations: 27     Fields:    Translation:HumansCells
  46. Nübling R, Kaluscha R, Krischak G, Kriz D, Martin H, Müller G, Renzland J, Reuss-Borst M, Schmidt J, Kaiser U, Toepler E. [Outcome Quality in Medical Rehabilitation: Relationship Between "Patient-Reported Outcomes" (PROs) and Social Security Contributions]. Rehabilitation (Stuttg). 2017 Feb; 56(1):22-30. PMID: 28219098.
    Citations:    Fields:    Translation:Humans
  47. Ross RA, Kaiser UB. Reproductive endocrinology: The emotional cost of contraception. Nat Rev Endocrinol. 2016 12 08; 13(1):7-9. PMID: 27929034.
    Citations: 2     Fields:    Translation:Humans
  48. Cote DJ, Smith TR, Sandler CN, Gupta T, Bale TA, Bi WL, Dunn IF, De Girolami U, Woodmansee WW, Kaiser UB, Laws ER. Functional Gonadotroph Adenomas: Case Series and Report of Literature. Neurosurgery. 2016 Dec; 79(6):823-831. PMID: 26692108.
    Citations: 4     Fields:    Translation:HumansCells
  49. Mei Y, Bi WL, Greenwald NF, Du Z, Agar NY, Kaiser UB, Woodmansee WW, Reardon DA, Freeman GJ, Fecci PE, Laws ER, Santagata S, Dunn GP, Dunn IF. Increased expression of programmed death ligand 1 (PD-L1) in human pituitary tumors. Oncotarget. 2016 Nov 22; 7(47):76565-76576. PMID: 27655724.
    Citations: 27     Fields:    Translation:Humans
  50. Stecchini MF, Macedo DB, Reis AC, Abreu AP, Moreira AC, Castro M, Kaiser UB, Latronico AC, Antonini SR. Time Course of Central Precocious Puberty Development Caused by an MKRN3 Gene Mutation: A Prismatic Case. Horm Res Paediatr. 2016; 86(2):126-130. PMID: 27424312.
    Citations: 3     Fields:    Translation:Humans
  51. Bessa DS, Macedo DB, Brito VN, França MM, Montenegro LR, Cunha-Silva M, Silveira LG, Hummel T, Bergadá I, Braslavsky D, Abreu AP, Dauber A, Mendonca BB, Kaiser UB, Latronico AC. High Frequency of MKRN3 Mutations in Male Central Precocious Puberty Previously Classified as Idiopathic. Neuroendocrinology. 2017; 105(1):17-25. PMID: 27225315.
    Citations: 19     Fields:    Translation:Humans
  52. Simavli S, Abreu AP, Kwaan MR, Dluhy RG, Yanushpolsky EH, Feltmate C, Cerda SR, Carroll RS, Kaiser UB, Kuohung W. Candidate gene analysis in a case of congenital absence of the endometrium. Fertil Res Pract. 2016; 2:3. PMID: 28620530.
    Citations:    
  53. Abreu AP, Kaiser UB. Pubertal development and regulation. Lancet Diabetes Endocrinol. 2016 Mar; 4(3):254-264. PMID: 26852256.
    Citations: 59     Fields:    Translation:Humans
  54. Thompson IR, Ciccone NA, Zhou Q, Xu S, Khogeer A, Carroll RS, Kaiser UB. GnRH Pulse Frequency Control of Fshb Gene Expression Is Mediated via ERK1/2 Regulation of ICER. Mol Endocrinol. 2016 Mar; 30(3):348-60. PMID: 26835742.
    Citations: 6     Fields:    Translation:AnimalsCells
  55. Kaiser UB. Decade in review-reproductive endocrinology: Understanding reproductive endocrine disorders. Nat Rev Endocrinol. 2015 Nov; 11(11):640-1. PMID: 26460342.
    Citations: 1     Fields:    Translation:Humans
  56. Min L, Leon S, Li H, Pinilla L, Carroll RS, Tena-Sempere M, Kaiser UB. RF9 Acts as a KISS1R Agonist In Vivo and In Vitro. Endocrinology. 2015 Dec; 156(12):4639-48. PMID: 26418326.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  57. Babwah AV, Navarro VM, Ahow M, Pampillo M, Nash C, Fayazi M, Calder M, Elbert A, Urbanski HF, Wettschureck N, Offermanns S, Carroll RS, Bhattacharya M, Tobet SA, Kaiser UB. GnRH Neuron-Specific Ablation of Gaq/11 Results in Only Partial Inactivation of the Neuroendocrine-Reproductive Axis in Both Male and Female Mice: In Vivo Evidence for Kiss1r-Coupled Gaq/11-Independent GnRH Secretion. J Neurosci. 2015 Sep 16; 35(37):12903-16. PMID: 26377475.
    Citations: 7     Fields:    Translation:AnimalsCells
  58. Min L, Hodi FS, Kaiser UB. Corticosteroids and immune checkpoint blockade. Aging (Albany NY). 2015 Aug; 7(8):521-2. PMID: 26298620.
    Citations: 9     Fields:    Translation:HumansAnimals
  59. Goldberg MA, Kaiser UB. Editorial: The Rise of the Asterisk: One Step to Facilitate Team Science. Mol Endocrinol. 2015 Jul; 29(7):943-5. PMID: 26132706.
    Citations: 2     Fields:    Translation:Humans
  60. Min L, Nie M, Zhang A, Wen J, Noel SD, Lee V, Carroll RS, Kaiser UB. Computational Analysis of Missense Variants of G Protein-Coupled Receptors Involved in the Neuroendocrine Regulation of Reproduction. Neuroendocrinology. 2016; 103(3-4):230-9. PMID: 26088945.
    Citations: 3     Fields:    Translation:Humans
  61. Abreu AP, Macedo DB, Brito VN, Kaiser UB, Latronico AC. A new pathway in the control of the initiation of puberty: the MKRN3 gene. J Mol Endocrinol. 2015 Jun; 54(3):R131-9. PMID: 25957321.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  62. Kaiser UB. Cushing's disease: towards precision medicine. Cell Res. 2015 Jun; 25(6):649-50. PMID: 25930709.
    Citations: 3     Fields:    Translation:HumansCells
  63. Simavli S, Thompson IR, Maguire CA, Gill JC, Carroll RS, Wolfe A, Kaiser UB, Navarro VM. Substance p regulates puberty onset and fertility in the female mouse. Endocrinology. 2015 Jun; 156(6):2313-22. PMID: 25856429.
    Citations: 17     Fields:    Translation:Animals
  64. Min L, Hodi FS, Giobbie-Hurder A, Ott PA, Luke JJ, Donahue H, Davis M, Carroll RS, Kaiser UB. Systemic high-dose corticosteroid treatment does not improve the outcome of ipilimumab-related hypophysitis: a retrospective cohort study. Clin Cancer Res. 2015 Feb 15; 21(4):749-55. PMID: 25538262.
    Citations: 50     Fields:    Translation:Humans
  65. Navarro VM, Bosch MA, León S, Simavli S, True C, Pinilla L, Carroll RS, Seminara SB, Tena-Sempere M, Rønnekleiv OK, Kaiser UB. The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction. Endocrinology. 2015 Feb; 156(2):627-37. PMID: 25422875.
    Citations: 28     Fields:    Translation:Animals
  66. Kaiser UB. Editorial: advances in neuroscience: the BRAIN initiative and implications for neuroendocrinology. Mol Endocrinol. 2014 Oct; 28(10):1589-91. PMID: 25271790.
    Citations: 1     Fields:    Translation:Humans
  67. Ahow M, Min L, Pampillo M, Nash C, Wen J, Soltis K, Carroll RS, Glidewell-Kenney CA, Mellon PL, Bhattacharya M, Tobet SA, Kaiser UB, Babwah AV. KISS1R signals independently of Gaq/11 and triggers LH secretion via the ß-arrestin pathway in the male mouse. Endocrinology. 2014 Nov; 155(11):4433-46. PMID: 25147978.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  68. Beneduzzi D, Trarbach EB, Min L, Jorge AA, Garmes HM, Renk AC, Fichna M, Fichna P, Arantes KA, Costa EM, Zhang A, Adeola O, Wen J, Carroll RS, Mendonça BB, Kaiser UB, Latronico AC, Silveira LF. Role of gonadotropin-releasing hormone receptor mutations in patients with a wide spectrum of pubertal delay. Fertil Steril. 2014 Sep; 102(3):838-846.e2. PMID: 25016926.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  69. Martin C, Navarro VM, Simavli S, Vong L, Carroll RS, Lowell BB, Kaiser UB. Leptin-responsive GABAergic neurons regulate fertility through pathways that result in reduced kisspeptinergic tone. J Neurosci. 2014 Apr 23; 34(17):6047-56. PMID: 24760864.
    Citations: 23     Fields:    Translation:AnimalsCells
  70. Macedo DB, Abreu AP, Reis AC, Montenegro LR, Dauber A, Beneduzzi D, Cukier P, Silveira LF, Teles MG, Carroll RS, Junior GG, Filho GG, Gucev Z, Arnhold IJ, de Castro M, Moreira AC, Martinelli CE, Hirschhorn JN, Mendonca BB, Brito VN, Antonini SR, Kaiser UB, Latronico AC. Central precocious puberty that appears to be sporadic caused by paternally inherited mutations in the imprinted gene makorin ring finger 3. J Clin Endocrinol Metab. 2014 Jun; 99(6):E1097-103. PMID: 24628548.
    Citations: 39     Fields:    Translation:Humans
  71. Noel SD, Abreu AP, Xu S, Muyide T, Gianetti E, Tusset C, Carroll J, Latronico AC, Seminara SB, Carroll RS, Kaiser UB. TACR3 mutations disrupt NK3R function through distinct mechanisms in GnRH-deficient patients. FASEB J. 2014 Apr; 28(4):1924-37. PMID: 24376026.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  72. Min L, Soltis K, Reis AC, Xu S, Kuohung W, Jain M, Carroll RS, Kaiser UB. Dynamic kisspeptin receptor trafficking modulates kisspeptin-mediated calcium signaling. Mol Endocrinol. 2014 Jan; 28(1):16-27. PMID: 24295737.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  73. Magill JC, Ciccone NA, Kaiser UB. A mathematical model of pulse-coded hormone signal responses in pituitary gonadotroph cells. Math Biosci. 2013 Nov; 246(1):38-46. PMID: 24095971.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  74. Thompson IR, Kaiser UB. GnRH pulse frequency-dependent differential regulation of LH and FSH gene expression. Mol Cell Endocrinol. 2014 Mar 25; 385(1-2):28-35. PMID: 24056171.
    Citations: 38     Fields:    Translation:HumansAnimals
  75. Navarro VM, Kaiser UB. Metabolic influences on neuroendocrine regulation of reproduction. Curr Opin Endocrinol Diabetes Obes. 2013 Aug; 20(4):335-41. PMID: 23807606.
    Citations: 15     Fields:    Translation:Humans
  76. Abreu AP, Dauber A, Macedo DB, Noel SD, Brito VN, Gill JC, Cukier P, Thompson IR, Navarro VM, Gagliardi PC, Rodrigues T, Kochi C, Longui CA, Beckers D, de Zegher F, Montenegro LR, Mendonca BB, Carroll RS, Hirschhorn JN, Latronico AC, Kaiser UB. Central precocious puberty caused by mutations in the imprinted gene MKRN3. N Engl J Med. 2013 Jun 27; 368(26):2467-75. PMID: 23738509.
    Citations: 113     Fields:    Translation:HumansAnimals
  77. Thompson IR, Ciccone NA, Xu S, Zaytseva S, Carroll RS, Kaiser UB. GnRH pulse frequency-dependent stimulation of FSHß transcription is mediated via activation of PKA and CREB. Mol Endocrinol. 2013 Apr; 27(4):606-18. PMID: 23393127.
    Citations: 22     Fields:    Translation:AnimalsCells
  78. Bianco SD, Kaiser UB. Molecular biology of the kisspeptin receptor: signaling, function, and mutations. Adv Exp Med Biol. 2013; 784:133-58. PMID: 23550005.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  79. Fang R, Chen F, Dong Z, Hu D, Barbera AJ, Clark EA, Fang J, Yang Y, Mei P, Rutenberg M, Li Z, Zhang Y, Xu Y, Yang H, Wang P, Simon MD, Zhou Q, Li J, Marynick MP, Li X, Lu H, Kaiser UB, Kingston RE, Xu Y, Shi YG. LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation. Mol Cell. 2013 Feb 07; 49(3):558-70. PMID: 23260659.
    Citations: 26     Fields:    Translation:HumansCells
  80. Xu Y, Xu C, Kato A, Tempel W, Abreu JG, Bian C, Hu Y, Hu D, Zhao B, Cerovina T, Diao J, Wu F, He HH, Cui Q, Clark E, Ma C, Barbara A, Veenstra GJ, Xu G, Kaiser UB, Liu XS, Sugrue SP, He X, Min J, Kato Y, Shi YG. Tet3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development. Cell. 2012 Dec 07; 151(6):1200-13. PMID: 23217707.
    Citations: 100     Fields:    Translation:AnimalsCells
  81. Tusset C, Noel SD, Trarbach EB, Silveira LF, Jorge AA, Brito VN, Cukier P, Seminara SB, Mendonça BB, Kaiser UB, Latronico AC. Mutational analysis of TAC3 and TACR3 genes in patients with idiopathic central pubertal disorders. Arq Bras Endocrinol Metabol. 2012 Dec; 56(9):646-52. PMID: 23329188.
    Citations: 15     Fields:    Translation:Humans
  82. Babwah AV, Pampillo M, Min L, Kaiser UB, Bhattacharya M. Single-cell analyses reveal that KISS1R-expressing cells undergo sustained kisspeptin-induced signaling that is dependent upon an influx of extracellular Ca2+. Endocrinology. 2012 Dec; 153(12):5875-87. PMID: 23070548.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  83. Kaiser UB. Hyperprolactinemia and infertility: new insights. J Clin Invest. 2012 Oct; 122(10):3467-8. PMID: 23193578.
    Citations: 7     Fields:    
  84. Lian CG, Xu Y, Ceol C, Wu F, Larson A, Dresser K, Xu W, Tan L, Hu Y, Zhan Q, Lee CW, Hu D, Lian BQ, Kleffel S, Yang Y, Neiswender J, Khorasani AJ, Fang R, Lezcano C, Duncan LM, Scolyer RA, Thompson JF, Kakavand H, Houvras Y, Zon LI, Mihm MC, Kaiser UB, Schatton T, Woda BA, Murphy GF, Shi YG. Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma. Cell. 2012 Sep 14; 150(6):1135-46. PMID: 22980977.
    Citations: 289     Fields:    Translation:HumansCells
  85. Gill JC, Navarro VM, Kwong C, Noel SD, Martin C, Xu S, Clifton DK, Carroll RS, Steiner RA, Kaiser UB. Increased neurokinin B (Tac2) expression in the mouse arcuate nucleus is an early marker of pubertal onset with differential sensitivity to sex steroid-negative feedback than Kiss1. Endocrinology. 2012 Oct; 153(10):4883-93. PMID: 22893725.
    Citations: 30     Fields:    Translation:AnimalsCells
  86. Gianetti E, Hall JE, Au MG, Kaiser UB, Quinton R, Stewart JA, Metzger DL, Pitteloud N, Mericq V, Merino PM, Levitsky LL, Izatt L, Lang-Muritano M, Fujimoto VY, Dluhy RG, Chase ML, Crowley WF, Plummer L, Seminara SB. When genetic load does not correlate with phenotypic spectrum: lessons from the GnRH receptor (GNRHR). J Clin Endocrinol Metab. 2012 Sep; 97(9):E1798-807. PMID: 22745237.
    Citations: 15     Fields:    Translation:Humans
  87. Abreu AP, Noel SD, Xu S, Carroll RS, Latronico AC, Kaiser UB. Evidence of the importance of the first intracellular loop of prokineticin receptor 2 in receptor function. Mol Endocrinol. 2012 Aug; 26(8):1417-27. PMID: 22745195.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  88. Chan YM, Broder-Fingert S, Paraschos S, Lapatto R, Au M, Hughes V, Bianco SD, Min L, Plummer L, Cerrato F, De Guillebon A, Wu IH, Wahab F, Dwyer A, Kirsch S, Quinton R, Cheetham T, Ozata M, Ten S, Chanoine JP, Pitteloud N, Martin KA, Schiffmann R, Van der Kamp HJ, Nader S, Hall JE, Kaiser UB, Seminara SB. GnRH-deficient phenotypes in humans and mice with heterozygous variants in KISS1/Kiss1. J Clin Endocrinol Metab. 2011 Nov; 96(11):E1771-81. PMID: 21880801.
    Citations: 25     Fields:    Translation:HumansAnimals
  89. Noel SD, Kaiser UB. G protein-coupled receptors involved in GnRH regulation: molecular insights from human disease. Mol Cell Endocrinol. 2011 Oct 22; 346(1-2):91-101. PMID: 21736917.
    Citations: 14     Fields:    Translation:Humans
  90. Vaidya A, Kaiser UB, Levy BD, Loscalzo J. Clinical problem-solving. Lying low. N Engl J Med. 2011 Mar 03; 364(9):871-5. PMID: 21366479.
    Citations: 1     Fields:    Translation:Humans
  91. Ross JJ, Vaidya A, Kaiser UB. Interactive medical case. Lying low. N Engl J Med. 2011 Feb 10; 364(6):e10. PMID: 21306234.
    Citations: 1     Fields:    Translation:Humans
  92. Bianco SD, Vandepas L, Correa-Medina M, Gereben B, Mukherjee A, Kuohung W, Carroll R, Teles MG, Latronico AC, Kaiser UB. KISS1R intracellular trafficking and degradation: effect of the Arg386Pro disease-associated mutation. Endocrinology. 2011 Apr; 152(4):1616-26. PMID: 21285314.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  93. Martin C, Balasubramanian R, Dwyer AA, Au MG, Sidis Y, Kaiser UB, Seminara SB, Pitteloud N, Zhou QY, Crowley WF. The role of the prokineticin 2 pathway in human reproduction: evidence from the study of human and murine gene mutations. Endocr Rev. 2011 Apr; 32(2):225-46. PMID: 21037178.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  94. Zada G, Tirosh A, Kaiser UB, Laws ER, Woodmansee WW. Cushing's disease and idiopathic intracranial hypertension: case report and review of underlying pathophysiological mechanisms. J Clin Endocrinol Metab. 2010 Nov; 95(11):4850-4. PMID: 20739379.
    Citations: 9     Fields:    Translation:Humans
  95. Gill JC, Wang O, Kakar S, Martinelli E, Carroll RS, Kaiser UB. Reproductive hormone-dependent and -independent contributions to developmental changes in kisspeptin in GnRH-deficient hypogonadal mice. PLoS One. 2010 Jul 30; 5(7):e11911. PMID: 20689830.
    Citations: 39     Fields:    Translation:Animals
  96. Fang R, Barbera AJ, Xu Y, Rutenberg M, Leonor T, Bi Q, Lan F, Mei P, Yuan GC, Lian C, Peng J, Cheng D, Sui G, Kaiser UB, Shi Y, Shi YG. Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation. Mol Cell. 2010 Jul 30; 39(2):222-33. PMID: 20670891.
    Citations: 89     Fields:    Translation:HumansCells
  97. Balasubramanian R, Dwyer A, Seminara SB, Pitteloud N, Kaiser UB, Crowley WF. Human GnRH deficiency: a unique disease model to unravel the ontogeny of GnRH neurons. Neuroendocrinology. 2010; 92(2):81-99. PMID: 20606386.
    Citations: 31     Fields:    Translation:HumansAnimals
  98. Hamnvik OP, Laury AR, Laws ER, Kaiser UB. Lymphocytic hypophysitis with diabetes insipidus in a young man. Nat Rev Endocrinol. 2010 Aug; 6(8):464-70. PMID: 20585348.
    Citations: 7     Fields:    Translation:Humans
  99. Abreu AP, Kaiser UB, Latronico AC. The role of prokineticins in the pathogenesis of hypogonadotropic hypogonadism. Neuroendocrinology. 2010; 91(4):283-90. PMID: 20502053.
    Citations: 10     Fields:    Translation:HumansAnimals
  100. Sykiotis GP, Pitteloud N, Seminara SB, Kaiser UB, Crowley WF. Deciphering genetic disease in the genomic era: the model of GnRH deficiency. Sci Transl Med. 2010 May 19; 2(32):32rv2. PMID: 20484732.
    Citations: 21     Fields:    Translation:HumansAnimals
  101. Kuohung W, Burnett M, Mukhtyar D, Schuman E, Ni J, Crowley WF, Glicksman MA, Kaiser UB. A high-throughput small-molecule ligand screen targeted to agonists and antagonists of the G-protein-coupled receptor GPR54. J Biomol Screen. 2010 Jun; 15(5):508-17. PMID: 20460252.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  102. Teles MG, Trarbach EB, Noel SD, Guerra-Junior G, Jorge A, Beneduzzi D, Bianco SD, Mukherjee A, Baptista MT, Costa EM, De Castro M, Mendonça BB, Kaiser UB, Latronico AC. A novel homozygous splice acceptor site mutation of KISS1R in two siblings with normosmic isolated hypogonadotropic hypogonadism. Eur J Endocrinol. 2010 Jul; 163(1):29-34. PMID: 20371656.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  103. Gianetti E, Tusset C, Noel SD, Au MG, Dwyer AA, Hughes VA, Abreu AP, Carroll J, Trarbach E, Silveira LF, Costa EM, de Mendonça BB, de Castro M, Lofrano A, Hall JE, Bolu E, Ozata M, Quinton R, Amory JK, Stewart SE, Arlt W, Cole TR, Crowley WF, Kaiser UB, Latronico AC, Seminara SB. TAC3/TACR3 mutations reveal preferential activation of gonadotropin-releasing hormone release by neurokinin B in neonatal life followed by reversal in adulthood. J Clin Endocrinol Metab. 2010 Jun; 95(6):2857-67. PMID: 20332248.
    Citations: 93     Fields:    Translation:HumansAnimalsCells
  104. Silveira LG, Noel SD, Silveira-Neto AP, Abreu AP, Brito VN, Santos MG, Bianco SD, Kuohung W, Xu S, Gryngarten M, Escobar ME, Arnhold IJ, Mendonca BB, Kaiser UB, Latronico AC. Mutations of the KISS1 gene in disorders of puberty. J Clin Endocrinol Metab. 2010 May; 95(5):2276-80. PMID: 20237166.
    Citations: 76     Fields:    Translation:Humans
  105. Chamarthi B, Morris CA, Kaiser UB, Katz JT, Loscalzo J. Clinical problem-solving. Stalking the diagnosis. N Engl J Med. 2010 Mar 04; 362(9):834-9. PMID: 20200388.
    Citations: 2     Fields:    Translation:Humans
  106. Ciccone NA, Xu S, Lacza CT, Carroll RS, Kaiser UB. Frequency-dependent regulation of follicle-stimulating hormone beta by pulsatile gonadotropin-releasing hormone is mediated by functional antagonism of bZIP transcription factors. Mol Cell Biol. 2010 Feb; 30(4):1028-40. PMID: 20008557.
    Citations: 33     Fields:    Translation:AnimalsCells
  107. Raivio T, Sidis Y, Plummer L, Chen H, Ma J, Mukherjee A, Jacobson-Dickman E, Quinton R, Van Vliet G, Lavoie H, Hughes VA, Dwyer A, Hayes FJ, Xu S, Sparks S, Kaiser UB, Mohammadi M, Pitteloud N. Frequency of Impaired Fibroblast Growth Factor Receptor 1 Signaling as a Cause of Normosmic Idiopathic Hypogonadotropic Hypogonadism. Endocr Rev. 2009 Dec 01; 30(7):934. PMID: 28199515.
    Citations: 1     Fields:    
  108. Raivio T, Sidis Y, Plummer L, Chen H, Ma J, Mukherjee A, Jacobson-Dickman E, Quinton R, Van Vliet G, Lavoie H, Hughes VA, Dwyer A, Hayes FJ, Xu S, Sparks S, Kaiser UB, Mohammadi M, Pitteloud N. Impaired fibroblast growth factor receptor 1 signaling as a cause of normosmic idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2009 Nov; 94(11):4380-90. PMID: 19820032.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  109. Bianco SD, Kaiser UB. The genetic and molecular basis of idiopathic hypogonadotropic hypogonadism. Nat Rev Endocrinol. 2009 Oct; 5(10):569-76. PMID: 19707180.
    Citations: 81     Fields:    Translation:Humans
  110. Ciccone NA, Kaiser UB. The biology of gonadotroph regulation. Curr Opin Endocrinol Diabetes Obes. 2009 Aug; 16(4):321-7. PMID: 19491666.
    Citations: 24     Fields:    Translation:HumansCells
  111. Jeong KH, Gill JC, Nosé V, Parlow AF, Carroll RS, Kaiser UB. Expression of a gonadotropin-releasing hormone receptor-simian virus 40 T-antigen transgene has sex-specific effects on the reproductive axis. Endocrinology. 2009 Jul; 150(7):3383-91. PMID: 19282386.
    Citations: 1     Fields:    Translation:AnimalsCells
  112. Huebner G, Link H, Kohne CH, Stahl M, Kretzschmar A, Steinbach S, Folprecht G, Bernhard H, Al-Batran SE, Schoffski P, Burkart C, Kullmann F, Otremba B, Menges M, Hoffmann M, Kaiser U, Aldaoud A, Jahn A. Paclitaxel and carboplatin vs gemcitabine and vinorelbine in patients with adeno- or undifferentiated carcinoma of unknown primary: a randomised prospective phase II trial. Br J Cancer. 2009 Jan 13; 100(1):44-9. PMID: 19066607.
    Citations: 18     Fields:    Translation:HumansCTClinical Trials
  113. Ciccone NA, Lacza CT, Hou MY, Gregory SJ, Kam KY, Xu S, Kaiser UB. A composite element that binds basic helix loop helix and basic leucine zipper transcription factors is important for gonadotropin-releasing hormone regulation of the follicle-stimulating hormone beta gene. Mol Endocrinol. 2008 Aug; 22(8):1908-23. PMID: 18550775.
    Citations: 23     Fields:    Translation:AnimalsCells
  114. Kaiser UB. Genetic labeling: new approaches to creating a gonadotroph "ID". Endocrinology. 2008 Jun; 149(6):2699-700. PMID: 18493024.
    Citations:    Fields:    Translation:HumansCells
  115. Gill JC, Wadas B, Chen P, Portillo W, Reyna A, Jorgensen E, Mani S, Schwarting GA, Moenter SM, Tobet S, Kaiser UB. The gonadotropin-releasing hormone (GnRH) neuronal population is normal in size and distribution in GnRH-deficient and GnRH receptor-mutant hypogonadal mice. Endocrinology. 2008 Sep; 149(9):4596-604. PMID: 18499748.
    Citations: 18     Fields:    Translation:AnimalsCells
  116. Teles MG, Bianco SD, Brito VN, Trarbach EB, Kuohung W, Xu S, Seminara SB, Mendonca BB, Kaiser UB, Latronico AC. A GPR54-activating mutation in a patient with central precocious puberty. N Engl J Med. 2008 Feb 14; 358(7):709-15. PMID: 18272894.
    Citations: 132     Fields:    Translation:HumansCells
  117. Bédécarrats GY, Kaiser UB. Mutations in the human gonadotropin-releasing hormone receptor: insights into receptor biology and function. Semin Reprod Med. 2007 Sep; 25(5):368-78. PMID: 17710733.
    Citations: 20     Fields:    Translation:HumansCells
  118. Cogliati T, Delgado-Romero P, Norwitz ER, Guduric-Fuchs J, Kaiser UB, Wray S, Kirsch IR. Pubertal impairment in Nhlh2 null mice is associated with hypothalamic and pituitary deficiencies. Mol Endocrinol. 2007 Dec; 21(12):3013-27. PMID: 17717072.
    Citations: 9     Fields:    Translation:AnimalsCells
  119. Jeong KH, Bakowska JC, Song IO, Fu N, Breakefield XO, Kaiser UB. Improvement in reproductive parameters in hypogonadal female mice by regulated gene replacement therapy in the central nervous system. Gene Ther. 2007 Jul; 14(14):1092-101. PMID: 17476303.
    Citations: 1     Fields:    Translation:AnimalsCells
  120. Sell H, Kaiser U, Eckel J. Expression of chemokine receptors in insulin-resistant human skeletal muscle cells. Horm Metab Res. 2007 Apr; 39(4):244-9. PMID: 17447160.
    Citations: 4     Fields:    Translation:HumansCells
  121. Kuohung W, Kaiser UB. GPR54 and KiSS-1: role in the regulation of puberty and reproduction. Rev Endocr Metab Disord. 2006 Dec; 7(4):257-63. PMID: 17206526.
    Citations: 11     Fields:    Translation:Humans
  122. Boehme V, Zeynalova S, Kloess M, Loeffler M, Kaiser U, Pfreundschuh M, Schmitz N. Incidence and risk factors of central nervous system recurrence in aggressive lymphoma--a survey of 1693 patients treated in protocols of the German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL). Ann Oncol. 2007 Jan; 18(1):149-157. PMID: 17018708.
    Citations: 62     Fields:    Translation:Humans
  123. Chattopadhyay N, Jeong KH, Yano S, Huang S, Pang JL, Ren X, Terwilliger E, Kaiser UB, Vassilev PM, Pollak MR, Brown EM. Calcium receptor stimulates chemotaxis and secretion of MCP-1 in GnRH neurons in vitro: potential impact on reduced GnRH neuron population in CaR-null mice. Am J Physiol Endocrinol Metab. 2007 Feb; 292(2):E523-32. PMID: 17003237.
    Citations: 11     Fields:    Translation:AnimalsCells
  124. Mazhawidza W, Winters SJ, Kaiser UB, Kakar SS. Identification of gene networks modulated by activin in LbetaT2 cells using DNA microarray analysis. Histol Histopathol. 2006 02; 21(2):167-78. PMID: 16329041.
    Citations: 7     Fields:    Translation:AnimalsCells
  125. Kuohung W, Kaiser UB. GPR54 and KiSS-1: Role in the regulation of puberty and reproduction. Reviews in Endocrine and Metabolic Disorders. 2006.
  126. Kanasaki H, Bedecarrats GY, Kam KY, Xu S, Kaiser UB. Gonadotropin-releasing hormone pulse frequency-dependent activation of extracellular signal-regulated kinase pathways in perifused LbetaT2 cells. Endocrinology. 2005 Dec; 146(12):5503-13. PMID: 16141398.
    Citations: 44     Fields:    Translation:AnimalsCells
  127. Kaiser UB, Kuohung W. KiSS-1 and GPR54 as new players in gonadotropin regulation and puberty. Endocrine. 2005 Apr; 26(3):277-84. PMID: 16034182.
    Citations: 16     Fields:    Translation:HumansAnimals
  128. Seminara SB, Kaiser UB. New gatekeepers of reproduction: GPR54 and its cognate ligand, KiSS-1. Endocrinology. 2005 Apr; 146(4):1686-8. PMID: 15769900.
    Citations: 8     Fields:    Translation:Animals
  129. Kuohung W, Kaiser UB. GnRH and gonadotrpins. In Jameson JL and DeGroote, eds. Endocrinology. 2005.
  130. Jeong KH, Kaiser UB. GnRH regulation of gonadotropion biosynthesis and secretion. In: Knobil and Neill, eds. The Physiology of Reproduction. 2005.
  131. Pask AJ, Kanasaki H, Kaiser UB, Conn PM, Janovick JA, Stockton DW, Hess DL, Justice MJ, Behringer RR. A novel mouse model of hypogonadotrophic hypogonadism: N-ethyl-N-nitrosourea-induced gonadotropin-releasing hormone receptor gene mutation. Mol Endocrinol. 2005 Apr; 19(4):972-81. PMID: 15625238.
    Citations: 27     Fields:    Translation:AnimalsCells
  132. Kam KY, Jeong KH, Norwitz ER, Jorgensen EM, Kaiser UB. Oct-1 and nuclear factor Y bind to the SURG-1 element to direct basal and gonadotropin-releasing hormone (GnRH)-stimulated mouse GnRH receptor gene transcription. Mol Endocrinol. 2005 Jan; 19(1):148-62. PMID: 15388790.
    Citations: 15     Fields:    Translation:AnimalsCells
  133. Gregory SJ, Lacza CT, Detz AA, Xu S, Petrillo LA, Kaiser UB. Synergy between activin A and gonadotropin-releasing hormone in transcriptional activation of the rat follicle-stimulating hormone-beta gene. Mol Endocrinol. 2005 Jan; 19(1):237-54. PMID: 15375186.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  134. Gregory SJ, Kaiser UB. Regulation of gonadotropins by inhibin and activin. Semin Reprod Med. 2004 Aug; 22(3):253-67. PMID: 15319828.
    Citations: 40     Fields:    Translation:HumansAnimals
  135. Jeong KH, Chin WW, Kaiser UB. Essential role of the homeodomain for pituitary homeobox 1 activation of mouse gonadotropin-releasing hormone receptor gene expression through interactions with c-Jun and DNA. Mol Cell Biol. 2004 Jul; 24(14):6127-39. PMID: 15226417.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  136. Meysing AU, Kanasaki H, Bedecarrats GY, Acierno JS, Conn PM, Martin KA, Seminara SB, Hall JE, Crowley WF, Kaiser UB. GNRHR mutations in a woman with idiopathic hypogonadotropic hypogonadism highlight the differential sensitivity of luteinizing hormone and follicle-stimulating hormone to gonadotropin-releasing hormone. J Clin Endocrinol Metab. 2004 Jul; 89(7):3189-98. PMID: 15240592.
    Citations: 19     Fields:    Translation:HumansCells
  137. Gregory SJ, Kaiser UB. Regulation of gonadotropins by inhibin and activin. Seminara SB, Kaiser UB. 2004; 22:253-67.
  138. Seminara SB, Messager S, Chatzidaki EE, Thresher RR, Acierno JS, Shagoury JK, Bo-Abbas Y, Kuohung W, Schwinof KM, Hendrick AG, Zahn D, Dixon J, Kaiser UB, Slaugenhaupt SA, Gusella JF, O'Rahilly S, Carlton MB, Crowley WF, Aparicio SA, Colledge WH. The GPR54 gene as a regulator of puberty. N Engl J Med. 2003 Oct 23; 349(17):1614-27. PMID: 14573733.
    Citations: 692     Fields:    Translation:HumansAnimals
  139. Kaiser UB. The pathogenesis of the ovarian hyperstimulation syndrome. N Engl J Med. 2003 Aug 21; 349(8):729-32. PMID: 12930924.
    Citations: 11     Fields:    Translation:Humans
  140. Bédécarrats GY, Linher KD, Janovick JA, Beranova M, Kada F, Seminara SB, Michael Conn P, Kaiser UB. Four naturally occurring mutations in the human GnRH receptor affect ligand binding and receptor function. Mol Cell Endocrinol. 2003 Jul 31; 205(1-2):51-64. PMID: 12890567.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  141. Bédécarrats GY, O'Neill FH, Norwitz ER, Kaiser UB, Teixeira J. Regulation of gonadotropin gene expression by Mullerian inhibiting substance. Proc Natl Acad Sci U S A. 2003 Aug 05; 100(16):9348-53. PMID: 12878721.
    Citations: 15     Fields:    Translation:AnimalsCells
  142. Bédécarrats GY, Kaiser UB. Differential regulation of gonadotropin subunit gene promoter activity by pulsatile gonadotropin-releasing hormone (GnRH) in perifused L beta T2 cells: role of GnRH receptor concentration. Endocrinology. 2003 May; 144(5):1802-11. PMID: 12697686.
    Citations: 43     Fields:    Translation:AnimalsCells
  143. Bedecarrats GY, Linher KD, Kaiser UB. Two common naturally occurring mutations in the human gonadotropin-releasing hormone (GnRH) receptor have differential effects on gonadotropin gene expression and on GnRH-mediated signal transduction. J Clin Endocrinol Metab. 2003 Feb; 88(2):834-43. PMID: 12574221.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  144. Kaiser UB. Perspective: Pathogenesis of ovarian hyperstimulation syndrome: insights from FSH receptor mutations. New Engl J Med. 2003; 349:729-32.
  145. Zakaria MM, Jeong KH, Lacza C, Kaiser UB. Pituitary homeobox 1 activates the rat FSHbeta (rFSHbeta) gene through both direct and indirect interactions with the rFSHbeta gene promoter. Mol Endocrinol. 2002 Aug; 16(8):1840-52. PMID: 12145338.
    Citations: 16     Fields:    Translation:AnimalsCells
  146. Norwitz ER, Xu S, Xu J, Spiryda LB, Park JS, Jeong KH, McGee EA, Kaiser UB. Direct binding of AP-1 (Fos/Jun) proteins to a SMAD binding element facilitates both gonadotropin-releasing hormone (GnRH)- and activin-mediated transcriptional activation of the mouse GnRH receptor gene. J Biol Chem. 2002 Oct 04; 277(40):37469-78. PMID: 12145309.
    Citations: 24     Fields:    Translation:AnimalsCells
  147. Norwitz ER, Xu S, Jeong KH, Bédécarrats GY, Winebrenner LD, Chin WW, Kaiser UB. Activin A augments GnRH-mediated transcriptional activation of the mouse GnRH receptor gene. Endocrinology. 2002 Mar; 143(3):985-97. PMID: 11861523.
    Citations: 18     Fields:    Translation:AnimalsCells
  148. Norwitz ER, Xu S, Jeong KH, Be de Carrats GG, Winebrenner LD, Chin WW, Kaiser UB. Activin A Augments GnRH-Mediated Transcriptional Activation of the Mouse GnRH Receptor Gene. Endocrinology. 2002 Mar 01; 143(3):985-997. PMID: 28204468.
    Citations:    
  149. Costa EM, Bedecarrats GY, Mendonca BB, Arnhold IJ, Kaiser UB, Latronico AC. Two novel mutations in the gonadotropin-releasing hormone receptor gene in Brazilian patients with hypogonadotropic hypogonadism and normal olfaction. J Clin Endocrinol Metab. 2001 Jun; 86(6):2680-6. PMID: 11397871.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  150. Beranova M, Oliveira LM, Bédécarrats GY, Schipani E, Vallejo M, Ammini AC, Quintos JB, Hall JE, Martin KA, Hayes FJ, Pitteloud N, Kaiser UB, Crowley WF, Seminara SB. Prevalence, phenotypic spectrum, and modes of inheritance of gonadotropin-releasing hormone receptor mutations in idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2001 Apr; 86(4):1580-8. PMID: 11297587.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  151. Kaiser U. Pituitary gene therapy--hypotheses on the hypophysis. Endocrinology. 2001 Feb; 142(2):528-31. PMID: 11159820.
    Citations:    Fields:    Translation:HumansAnimalsCells
  152. Kaiser UB. Editorial: Pituitary Gene Therapy-Hypotheses on the Hypophysis. Endocrinology. 2001 Feb 01; 142(2):528-531. PMID: 28201234.
    Citations:    
  153. Kaiser UB, Hedley-Whyte ET. Weekly clinicopathological excerises: Case 15-2001: A 72-year old man with persistent fever and hypotension. New Engl J Med. 2001; 344:1536-42.
  154. Kaiser UB, Halvorson LM, Chen MT. Sp1, steroidogenic factor 1 (SF-1), and early growth response protein 1 (egr-1) binding sites form a tripartite gonadotropin-releasing hormone response element in the rat luteinizing hormone-beta gene promoter: an integral role for SF-1. Mol Endocrinol. 2000 Aug; 14(8):1235-45. PMID: 10935547.
    Citations: 39     Fields:    Translation:AnimalsCells
  155. Kaiser UB. Neuroendocrinology: editorial overview. Curr Opin Endocrinol and Diab. 2000; 7:151-2.
  156. Kaiser U, Uebelacker I, Havemann K. Non-Hodgkin's lymphoma protocols in the treatment of patients with Burkitt's lymphoma and lymphoblastic lymphoma: a report on 58 patients. Leuk Lymphoma. 1999 Dec; 36(1-2):101-8. PMID: 10613454.
    Citations: 7     Fields:    Translation:Humans
  157. Kaiser U, Weide R, Wolf M. Successful salvage treatment for relapse after autologous stem cell transplantation in a patient with Hodgkin's disease--a case report. Ann Hematol. 1999 Jan; 78(1):33-5. PMID: 10037267.
    Citations:    Fields:    Translation:Humans
  158. Halvorson LM, Kaiser UB, Chin WW. The protein kinase C system acts through the early growth response protein 1 to increase LHbeta gene expression in synergy with steroidogenic factor-1. Mol Endocrinol. 1999 Jan; 13(1):106-16. PMID: 9892016.
    Citations: 19     Fields:    Translation:AnimalsCells
  159. Kaiser UB. Molecular mechanisms of the regulation of gonadotropin gene expression by gonadotropin-releasing hormone. Mol Cells. 1998 Dec 31; 8(6):647-56. PMID: 9895115.
    Citations: 1     Fields:    Translation:HumansAnimals
  160. Mitsumori M, Shrieve DC, Alexander E, Kaiser UB, Richardson GE, Black PM, Loeffler JS. Initial clinical results of LINAC-based stereotactic radiosurgery and stereotactic radiotherapy for pituitary adenomas. Int J Radiat Oncol Biol Phys. 1998 Oct 01; 42(3):573-80. PMID: 9806517.
    Citations: 27     Fields:    Translation:Humans
  161. Kaiser UB, Sabbagh E, Chen MT, Chin WW, Saunders BD. Sp1 binds to the rat luteinizing hormone beta (LHbeta) gene promoter and mediates gonadotropin-releasing hormone-stimulated expression of the LHbeta subunit gene. J Biol Chem. 1998 May 22; 273(21):12943-51. PMID: 9582327.
    Citations: 10     Fields:    Translation:AnimalsCells
  162. Kaiser UB, Sabbagh E, Saunders BD, Chin WW. Identification of cis-acting deoxyribonucleic acid elements that mediate gonadotropin-releasing hormone stimulation of the rat luteinizing hormone beta-subunit gene. Endocrinology. 1998 May; 139(5):2443-51. PMID: 9564856.
    Citations: 3     Fields:    Translation:AnimalsCells
  163. Hiddemann W, Unterhalt M, Herrmann R, Wöltjen HH, Kreuser ED, Trümper L, Reuss-Borst M, Terhardt-Kasten E, Busch M, Neubauer A, Kaiser U, Hanrath RD, Middeke H, Helm G, Freund M, Stein H, Tiemann M, Parwaresch R. Mantle-cell lymphomas have more widespread disease and a slower response to chemotherapy compared with follicle-center lymphomas: results of a prospective comparative analysis of the German Low-Grade Lymphoma Study Group. J Clin Oncol. 1998 May; 16(5):1922-30. PMID: 9586911.
    Citations: 15     Fields:    Translation:HumansCTClinical Trials
  164. Kaiser UB, Sabbagh E, Saunders BD, Chin WW. Identification of cis-Acting Deoxyribonucleic Acid Elements That Mediate Gonadotropin-Releasing Hormone Stimulation of the Rat Luteinizing Hormone ß-Subunit Gene. Endocrinology. 1998 May 01; 139(5):2443-2451. PMID: 28200605.
    Citations:    
  165. Saunders BD, Sabbagh E, Chin WW, Kaiser UB. Differential use of signal transduction pathways in the gonadotropin-releasing hormone-mediated regulation of gonadotropin subunit gene expression. Endocrinology. 1998 Apr; 139(4):1835-43. PMID: 9528969.
    Citations: 13     Fields:    Translation:AnimalsCells
  166. Mitsumori M, Shrieve DC, Alexander K, Kaiser UB, Richardson GE, Black PM, Loeffler JS. Initial clinical results of LINAC-based stereotactic radiosurgery and sterostatic radiotherapy for pituitary ademomas. Int J Radiation Oncology Biol Phys. 1998; 42:573-80.
  167. Kaiser UB, Jakubowiak A, Steinberger A, Chin WW. Differential effects of gonadotropin-releasing hormone (GnRH) pulse frequency on gonadotropin subunit and GnRH receptor messenger ribonucleic acid levels in vitro. Endocrinology. 1997 Mar; 138(3):1224-31. PMID: 9048630.
    Citations: 61     Fields:    Translation:AnimalsCells
  168. Wimmel A, Schilli M, Kaiser U, Havemann K, Ramaswamy A, Branscheid D, Kogan E, Schuermann M. Preferential histiotypic expression of CD44-isoforms in human lung cancer. Lung Cancer. 1997 Mar; 16(2-3):151-72. PMID: 9152947.
    Citations: 2     Fields:    Translation:HumansCells
  169. Kaiser UB, Conn PM, Chin WW. Studies of gonadotropin-releasing hormone (GnRH) action using GnRH receptor-expressing pituitary cell lines. Endocr Rev. 1997 Feb; 18(1):46-70.