Harvard Catalyst Profiles

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Ursula Brigitte Kaiser, M.D.

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Mentoring
Available: 10/01/18, Expires: 09/30/19

An elaborate neural network integrating internal and external signals governs the onset of puberty and subsequent fertility. The precise nature and components of this network are not well established, but it is clear that puberty is triggered by the central increase in pulsatile gonadotropin-releasing hormone (GnRH) secretion, which stimulates the secretion of the pituitary gonadotropins, necessary for the activation of gonadal function. Our laboratory uses a translational approach to study the hormones and genes involved in the neuroendocrine regulation of reproductive development, puberty onset and subsequent fertility. Our approaches include studies of: 1. Hypothalamic and pituitary cell models and in vitro studies; 2. In vivo mouse models; and 3. Patients with clinical reproductive disorders. Potential Student Roles: (1) Assist with reproductive phenotyping of genetically modified mouse models (e.g., pubertal markers, estrous cyclicity); (2) Assist with human genetic studies, including review of human patient clinical data to correlate with genetic findings with clinical phenotypes, and DNA sequencing and sequence analysis, including analyses of exome sequence data; (3) Contribute to laboratory studies of human inducible pluripotent stem cell (hiPSC)-derived hypothalamic neurons that have been genetically modified by CRISPR-Cas9.

Gonadatropin Gene Expression; Reproductive Endocrinology
Summer, 06/08/00 - 08/26/00

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HD082314 (KAISER, URSULA B) Apr 1, 2015 - Jan 31, 2020
    NIH/NICHD
    Deciphering the functional role of MKRN3 in puberty and reproduction
    Role: Principal Investigator
  2. R21HD066495 (KAISER, URSULA B) Sep 15, 2010 - Aug 31, 2013
    NIH/NICHD
    The Epigenetic Regulation of Puberty
    Role: Principal Investigator
  3. R01HD061577 (KAISER, URSULA B) Sep 1, 2009 - Aug 31, 2012
    NIH/NICHD
    Use of Gene Therapy: A Tool to Study Reproductive Function
    Role: Principal Investigator
  4. R21HD050412 (KAISER, URSULA B) Aug 1, 2005 - Jul 31, 2008
    NIH/NICHD
    GENE THERAPY FOR RESCUE OF REPRODUCTIVE FUNCTION
    Role: Principal Investigator
  5. P50HD028138 (CROWLEY, WILLIAM FRANCIS) Apr 1, 1997 - Mar 31, 2021
    NIH/NICHD
    Harvard Reproductive Endocrine Sciences Center
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Clark EA, Wu F, Chen Y, Kang P, Kaiser UB, Fang R, Shi YG. GR and LSD1/KDM1A-Targeted Gene Activation Requires Selective H3K4me2 Demethylation at Enhancers. Cell Rep. 2019 Jun 18; 27(12):3522-3532.e3. PMID: 31216473.
    Citations:    
  2. Ma C, Hodi FS, Giobbie-Hurder A, Wang X, Zhou J, Zhang A, Zhou Y, Mao F, Angell TE, Andrews CP, Hu J, Barroso-Sousa R, Kaiser UB, Tolaney SM, Min L. The Impact of High-Dose Glucocorticoids on the Outcome of Immune-Checkpoint Inhibitor-Related Thyroid Disorders. Cancer Immunol Res. 2019 Jul; 7(7):1214-1220. PMID: 31088848.
    Citations:    
  3. Lee JA, Kuchakulla M, Arora H, Kulandavelu S, Gonzalez E, Masterson TA, Hare JM, Kaiser UB, Ramasamy R. Age Induced Nitroso-Redox Imbalance Leads to Subclinical Hypogonadism in Male Mice. Front Endocrinol (Lausanne). 2019; 10:190. PMID: 30984111.
    Citations:    
  4. Valadares LP, Meireles CG, De Toledo IP, Santarem de Oliveira R, Gonçalves de Castro LC, Abreu AP, Carroll RS, Latronico AC, Kaiser UB, Guerra ENS, Lofrano-Porto A. MKRN3 Mutations in Central Precocious Puberty: A Systematic Review and Meta-Analysis. J Endocr Soc. 2019 May 01; 3(5):979-995. PMID: 31041429.
    Citations:    
  5. Chang LS, Barroso-Sousa R, Tolaney SM, Hodi FS, Kaiser UB, Min L. Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints. Endocr Rev. 2019 02 01; 40(1):17-65. PMID: 30184160.
    Citations:    Fields:    
  6. Stamatiades GA, Carroll RS, Kaiser UB. GnRH-A Key Regulator of FSH. Endocrinology. 2019 Jan 01; 160(1):57-67. PMID: 30517625.
    Citations:    Fields:    
  7. Garrel G, Denoyelle C, L'Hôte D, Picard JY, Teixeira J, Kaiser UB, Laverrière JN, Cohen-Tannoudji J. GnRH Transactivates Human AMH Receptor Gene via Egr1 and FOXO1 in Gonadotrope Cells. Neuroendocrinology. 2019; 108(2):65-83. PMID: 30368511.
    Citations:    Fields:    
  8. Rich-Edwards JW, Kaiser UB, Chen GL, Manson JE, Goldstein JM. Sex and Gender Differences Research Design for Basic, Clinical, and Population Studies: Essentials for Investigators. Endocr Rev. 2018 08 01; 39(4):424-439. PMID: 29668873.
    Citations:    Fields:    
  9. Ross RA, Leon S, Madara JC, Schafer D, Fergani C, Maguire CA, Verstegen AM, Brengle E, Kong D, Herbison AE, Kaiser UB, Lowell BB, Navarro VM. PACAP neurons in the ventral premammillary nucleus regulate reproductive function in the female mouse. Elife. 2018 06 15; 7. PMID: 29905528.
    Citations:    Fields:    
  10. Macedo DB, França MM, Montenegro LR, Cunha-Silva M, Best DS, Abreu AP, Kaiser UB, Mendonca BB, Jorge AAL, Brito VN, Latronico AC. Central Precocious Puberty Caused by a Heterozygous Deletion in the MKRN3 Promoter Region. Neuroendocrinology. 2018; 107(2):127-132. PMID: 29763903.
    Citations: 1     Fields:    Translation:HumansCells
  11. Masterson TA, Arora H, Kulandavelu S, Carroll RS, Kaiser UB, Gultekin SH, Hare JM, Ramasamy R. S-Nitrosoglutathione Reductase (GSNOR) Deficiency Results in Secondary Hypogonadism. J Sex Med. 2018 May; 15(5):654-661. PMID: 29606625.
    Citations: 1     Fields:    
  12. Barroso-Sousa R, Ott PA, Hodi FS, Kaiser UB, Tolaney SM, Min L. Endocrine dysfunction induced by immune checkpoint inhibitors: Practical recommendations for diagnosis and clinical management. Cancer. 2018 Mar 15; 124(6):1111-1121. PMID: 29313945.
    Citations:    Fields:    
  13. Neustadt K, Deckert S, Kopkow C, Preißler A, Bosse B, Funke C, Jacobi L, Mattenklodt P, Nagel B, Seidel P, Sittl R, Steffen E, Sabatowski R, Schmitt J, Kaiser U. [What does pain intensity mean from the patient perspective? : A qualitative study on the patient perspective of pain intensity as an outcome parameter in treatment evaluation and on the interpretability of pain intensity measurements]. Schmerz. 2017 Dec; 31(6):580-593. PMID: 28660417.
    Citations:    Fields:    
  14. Stamatiades GA, Kaiser UB. Gonadotropin regulation by pulsatile GnRH: Signaling and gene expression. Mol Cell Endocrinol. 2018 03 05; 463:131-141. PMID: 29102564.
    Citations: 1     Fields:    
  15. Mao JF, Liu ZX, Nie M, Wang X, Xu HL, Huang BK, Zheng JJ, Min L, Kaiser UB, Wu XY. Pulsatile gonadotropin-releasing hormone therapy is associated with earlier spermatogenesis compared to combined gonadotropin therapy in patients with congenital hypogonadotropic hypogonadism. Asian J Androl. 2017 Nov-Dec; 19(6):680-685. PMID: 28051040.
    Citations: 1     Fields:    Translation:Humans
  16. Lee H, Hodi FS, Giobbie-Hurder A, Ott PA, Buchbinder EI, Haq R, Tolaney S, Barroso-Sousa R, Zhang K, Donahue H, Davis M, Gargano ME, Kelley KM, Carroll RS, Kaiser UB, Min L. Characterization of Thyroid Disorders in Patients Receiving Immune Checkpoint Inhibition Therapy. Cancer Immunol Res. 2017 12; 5(12):1133-1140. PMID: 29079654.
    Citations: 2     Fields:    Translation:HumansCells
  17. Stoppiello CT, Biskupek J, Li ZY, Rance GA, Botos A, Fogarty RM, Bourne RA, Yuan J, Lovelock KRJ, Thompson P, Fay MW, Kaiser U, Chamberlain TW, Khlobystov AN. A one-pot-one-reactant synthesis of platinum compounds at the nanoscale. Nanoscale. 2017 Oct 05; 9(38):14385-14394. PMID: 28948268.
    Citations:    Fields:    
  18. Maguire CA, León S, Carroll RS, Kaiser UB, Navarro VM. Altered circadian feeding behavior and improvement of metabolic syndrome in obese Tac1-deficient mice. Int J Obes (Lond). 2017 Dec; 41(12):1798-1804. PMID: 28775376.
    Citations: 1     Fields:    Translation:AnimalsCells
  19. Maguire CA, Song YB, Wu M, León S, Carroll RS, Alreja M, Kaiser UB, Navarro VM. Tac1 Signaling Is Required for Sexual Maturation and Responsiveness of GnRH Neurons to Kisspeptin in the Male Mouse. Endocrinology. 2017 07 01; 158(7):2319-2329. PMID: 28444173.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  20. Zheng J, Mao J, Xu H, Wang X, Huang B, Liu Z, Cui M, Xiong S, Ma W, Min L, Kaiser UB, Nie M, Wu X. Pulsatile GnRH Therapy May Restore Hypothalamus-Pituitary-Testis Axis Function in Patients With Congenital Combined Pituitary Hormone Deficiency: A Prospective, Self-Controlled Trial. J Clin Endocrinol Metab. 2017 07 01; 102(7):2291-2300. PMID: 28368486.
    Citations: 1     Fields:    Translation:Humans
  21. Bi WL, Greenwald NF, Ramkissoon SH, Abedalthagafi M, Coy SM, Ligon KL, Mei Y, MacConaill L, Ducar M, Min L, Santagata S, Kaiser UB, Beroukhim R, Laws ER, Dunn IF. Clinical Identification of Oncogenic Drivers and Copy-Number Alterations in Pituitary Tumors. Endocrinology. 2017 07 01; 158(7):2284-2291. PMID: 28486603.
    Citations: 3     Fields:    Translation:HumansCells
  22. Dauber A, Cunha-Silva M, Macedo DB, Brito VN, Abreu AP, Roberts SA, Montenegro LR, Andrew M, Kirby A, Weirauch MT, Labilloy G, Bessa DS, Carroll RS, Jacobs DC, Chappell PE, Mendonca BB, Haig D, Kaiser UB, Latronico AC. Paternally Inherited DLK1 Deletion Associated With Familial Central Precocious Puberty. J Clin Endocrinol Metab. 2017 05 01; 102(5):1557-1567. PMID: 28324015.
    Citations: 7     Fields:    Translation:Humans
  23. Ercan A, Kohrt WM, Cui J, Deane KD, Pezer M, Yu EW, Hausmann JS, Campbell H, Kaiser UB, Rudd PM, Lauc G, Wilson JF, Finkelstein JS, Nigrovic PA. Estrogens regulate glycosylation of IgG in women and men. JCI Insight. 2017 02 23; 2(4):e89703. PMID: 28239652.
    Citations: 7     Fields:    
  24. Nübling R, Kaluscha R, Krischak G, Kriz D, Martin H, Müller G, Renzland J, Reuss-Borst M, Schmidt J, Kaiser U, Toepler E. [Outcome Quality in Medical Rehabilitation: Relationship Between "Patient-Reported Outcomes" (PROs) and Social Security Contributions]. Rehabilitation (Stuttg). 2017 Feb; 56(1):22-30. PMID: 28219098.
    Citations:    Fields:    Translation:Humans
  25. Ross RA, Kaiser UB. Reproductive endocrinology: The emotional cost of contraception. Nat Rev Endocrinol. 2016 12 08; 13(1):7-9. PMID: 27929034.
    Citations:    Fields:    Translation:Humans
  26. Cote DJ, Smith TR, Sandler CN, Gupta T, Bale TA, Bi WL, Dunn IF, De Girolami U, Woodmansee WW, Kaiser UB, Laws ER. Functional Gonadotroph Adenomas: Case Series and Report of Literature. Neurosurgery. 2016 Dec; 79(6):823-831. PMID: 26692108.
    Citations:    Fields:    Translation:HumansCells
  27. Mei Y, Bi WL, Greenwald NF, Du Z, Agar NY, Kaiser UB, Woodmansee WW, Reardon DA, Freeman GJ, Fecci PE, Laws ER, Santagata S, Dunn GP, Dunn IF. Increased expression of programmed death ligand 1 (PD-L1) in human pituitary tumors. Oncotarget. 2016 Nov 22; 7(47):76565-76576. PMID: 27655724.
    Citations: 5     Fields:    Translation:Humans
  28. Stecchini MF, Macedo DB, Reis AC, Abreu AP, Moreira AC, Castro M, Kaiser UB, Latronico AC, Antonini SR. Time Course of Central Precocious Puberty Development Caused by an MKRN3 Gene Mutation: A Prismatic Case. Horm Res Paediatr. 2016; 86(2):126-130. PMID: 27424312.
    Citations:    Fields:    Translation:Humans
  29. Bessa DS, Macedo DB, Brito VN, França MM, Montenegro LR, Cunha-Silva M, Silveira LG, Hummel T, Bergadá I, Braslavsky D, Abreu AP, Dauber A, Mendonca BB, Kaiser UB, Latronico AC. High Frequency of MKRN3 Mutations in Male Central Precocious Puberty Previously Classified as Idiopathic. Neuroendocrinology. 2017; 105(1):17-25. PMID: 27225315.
    Citations: 7     Fields:    Translation:Humans
  30. Simavli S, Abreu AP, Kwaan MR, Dluhy RG, Yanushpolsky EH, Feltmate C, Cerda SR, Carroll RS, Kaiser UB, Kuohung W. Candidate gene analysis in a case of congenital absence of the endometrium. Fertil Res Pract. 2016; 2:3. PMID: 28620530.
    Citations:    
  31. Abreu AP, Kaiser UB. Pubertal development and regulation. Lancet Diabetes Endocrinol. 2016 Mar; 4(3):254-264. PMID: 26852256.
    Citations: 12     Fields:    Translation:Humans
  32. Thompson IR, Ciccone NA, Zhou Q, Xu S, Khogeer A, Carroll RS, Kaiser UB. GnRH Pulse Frequency Control of Fshb Gene Expression Is Mediated via ERK1/2 Regulation of ICER. Mol Endocrinol. 2016 Mar; 30(3):348-60. PMID: 26835742.
    Citations: 2     Fields:    Translation:AnimalsCells
  33. Kaiser UB. Decade in review-reproductive endocrinology: Understanding reproductive endocrine disorders. Nat Rev Endocrinol. 2015 Nov; 11(11):640-1. PMID: 26460342.
    Citations:    Fields:    Translation:Humans
  34. Min L, Leon S, Li H, Pinilla L, Carroll RS, Tena-Sempere M, Kaiser UB. RF9 Acts as a KISS1R Agonist In Vivo and In Vitro. Endocrinology. 2015 Dec; 156(12):4639-48. PMID: 26418326.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  35. Babwah AV, Navarro VM, Ahow M, Pampillo M, Nash C, Fayazi M, Calder M, Elbert A, Urbanski HF, Wettschureck N, Offermanns S, Carroll RS, Bhattacharya M, Tobet SA, Kaiser UB. GnRH Neuron-Specific Ablation of Gaq/11 Results in Only Partial Inactivation of the Neuroendocrine-Reproductive Axis in Both Male and Female Mice: In Vivo Evidence for Kiss1r-Coupled Gaq/11-Independent GnRH Secretion. J Neurosci. 2015 Sep 16; 35(37):12903-16. PMID: 26377475.
    Citations: 4     Fields:    Translation:AnimalsCells
  36. Min L, Hodi FS, Kaiser UB. Corticosteroids and immune checkpoint blockade. Aging (Albany NY). 2015 Aug; 7(8):521-2. PMID: 26298620.
    Citations: 1     Fields:    Translation:HumansAnimals
  37. Goldberg MA, Kaiser UB. Editorial: The Rise of the Asterisk: One Step to Facilitate Team Science. Mol Endocrinol. 2015 Jul; 29(7):943-5. PMID: 26132706.
    Citations: 2     Fields:    Translation:Humans
  38. Min L, Nie M, Zhang A, Wen J, Noel SD, Lee V, Carroll RS, Kaiser UB. Computational Analysis of Missense Variants of G Protein-Coupled Receptors Involved in the Neuroendocrine Regulation of Reproduction. Neuroendocrinology. 2016; 103(3-4):230-9. PMID: 26088945.
    Citations: 2     Fields:    Translation:Humans
  39. Abreu AP, Macedo DB, Brito VN, Kaiser UB, Latronico AC. A new pathway in the control of the initiation of puberty: the MKRN3 gene. J Mol Endocrinol. 2015 Jun; 54(3):R131-9. PMID: 25957321.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  40. Kaiser UB. Cushing's disease: towards precision medicine. Cell Res. 2015 Jun; 25(6):649-50. PMID: 25930709.
    Citations:    Fields:    Translation:HumansCells
  41. Simavli S, Thompson IR, Maguire CA, Gill JC, Carroll RS, Wolfe A, Kaiser UB, Navarro VM. Substance p regulates puberty onset and fertility in the female mouse. Endocrinology. 2015 Jun; 156(6):2313-22. PMID: 25856429.
    Citations: 9     Fields:    Translation:Animals
  42. Min L, Hodi FS, Giobbie-Hurder A, Ott PA, Luke JJ, Donahue H, Davis M, Carroll RS, Kaiser UB. Systemic high-dose corticosteroid treatment does not improve the outcome of ipilimumab-related hypophysitis: a retrospective cohort study. Clin Cancer Res. 2015 Feb 15; 21(4):749-55. PMID: 25538262.
    Citations: 22     Fields:    Translation:Humans
  43. Navarro VM, Bosch MA, León S, Simavli S, True C, Pinilla L, Carroll RS, Seminara SB, Tena-Sempere M, Rønnekleiv OK, Kaiser UB. The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction. Endocrinology. 2015 Feb; 156(2):627-37. PMID: 25422875.
    Citations: 19     Fields:    Translation:Animals
  44. Kaiser UB. Editorial: advances in neuroscience: the BRAIN initiative and implications for neuroendocrinology. Mol Endocrinol. 2014 Oct; 28(10):1589-91. PMID: 25271790.
    Citations:    Fields:    Translation:Humans
  45. Ahow M, Min L, Pampillo M, Nash C, Wen J, Soltis K, Carroll RS, Glidewell-Kenney CA, Mellon PL, Bhattacharya M, Tobet SA, Kaiser UB, Babwah AV. KISS1R signals independently of Gaq/11 and triggers LH secretion via the ß-arrestin pathway in the male mouse. Endocrinology. 2014 Nov; 155(11):4433-46. PMID: 25147978.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  46. Beneduzzi D, Trarbach EB, Min L, Jorge AA, Garmes HM, Renk AC, Fichna M, Fichna P, Arantes KA, Costa EM, Zhang A, Adeola O, Wen J, Carroll RS, Mendonça BB, Kaiser UB, Latronico AC, Silveira LF. Role of gonadotropin-releasing hormone receptor mutations in patients with a wide spectrum of pubertal delay. Fertil Steril. 2014 Sep; 102(3):838-846.e2. PMID: 25016926.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  47. Martin C, Navarro VM, Simavli S, Vong L, Carroll RS, Lowell BB, Kaiser UB. Leptin-responsive GABAergic neurons regulate fertility through pathways that result in reduced kisspeptinergic tone. J Neurosci. 2014 Apr 23; 34(17):6047-56. PMID: 24760864.
    Citations: 16     Fields:    Translation:AnimalsCells
  48. Macedo DB, Abreu AP, Reis AC, Montenegro LR, Dauber A, Beneduzzi D, Cukier P, Silveira LF, Teles MG, Carroll RS, Junior GG, Filho GG, Gucev Z, Arnhold IJ, de Castro M, Moreira AC, Martinelli CE, Hirschhorn JN, Mendonca BB, Brito VN, Antonini SR, Kaiser UB, Latronico AC. Central precocious puberty that appears to be sporadic caused by paternally inherited mutations in the imprinted gene makorin ring finger 3. J Clin Endocrinol Metab. 2014 Jun; 99(6):E1097-103. PMID: 24628548.
    Citations: 22     Fields:    Translation:Humans
  49. Noel SD, Abreu AP, Xu S, Muyide T, Gianetti E, Tusset C, Carroll J, Latronico AC, Seminara SB, Carroll RS, Kaiser UB. TACR3 mutations disrupt NK3R function through distinct mechanisms in GnRH-deficient patients. FASEB J. 2014 Apr; 28(4):1924-37. PMID: 24376026.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  50. Min L, Soltis K, Reis AC, Xu S, Kuohung W, Jain M, Carroll RS, Kaiser UB. Dynamic kisspeptin receptor trafficking modulates kisspeptin-mediated calcium signaling. Mol Endocrinol. 2014 Jan; 28(1):16-27. PMID: 24295737.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  51. Magill JC, Ciccone NA, Kaiser UB. A mathematical model of pulse-coded hormone signal responses in pituitary gonadotroph cells. Math Biosci. 2013 Nov; 246(1):38-46. PMID: 24095971.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  52. Thompson IR, Kaiser UB. GnRH pulse frequency-dependent differential regulation of LH and FSH gene expression. Mol Cell Endocrinol. 2014 Mar 25; 385(1-2):28-35. PMID: 24056171.
    Citations: 25     Fields:    Translation:HumansAnimals
  53. Navarro VM, Kaiser UB. Metabolic influences on neuroendocrine regulation of reproduction. Curr Opin Endocrinol Diabetes Obes. 2013 Aug; 20(4):335-41. PMID: 23807606.
    Citations: 8     Fields:    Translation:Humans
  54. Abreu AP, Dauber A, Macedo DB, Noel SD, Brito VN, Gill JC, Cukier P, Thompson IR, Navarro VM, Gagliardi PC, Rodrigues T, Kochi C, Longui CA, Beckers D, de Zegher F, Montenegro LR, Mendonca BB, Carroll RS, Hirschhorn JN, Latronico AC, Kaiser UB. Central precocious puberty caused by mutations in the imprinted gene MKRN3. N Engl J Med. 2013 Jun 27; 368(26):2467-75. PMID: 23738509.
    Citations: 69     Fields:    Translation:HumansAnimals
  55. Thompson IR, Ciccone NA, Xu S, Zaytseva S, Carroll RS, Kaiser UB. GnRH pulse frequency-dependent stimulation of FSHß transcription is mediated via activation of PKA and CREB. Mol Endocrinol. 2013 Apr; 27(4):606-18. PMID: 23393127.
    Citations: 17     Fields:    Translation:AnimalsCells
  56. Bianco SD, Kaiser UB. Molecular biology of the kisspeptin receptor: signaling, function, and mutations. Adv Exp Med Biol. 2013; 784:133-58. PMID: 23550005.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  57. Fang R, Chen F, Dong Z, Hu D, Barbera AJ, Clark EA, Fang J, Yang Y, Mei P, Rutenberg M, Li Z, Zhang Y, Xu Y, Yang H, Wang P, Simon MD, Zhou Q, Li J, Marynick MP, Li X, Lu H, Kaiser UB, Kingston RE, Xu Y, Shi YG. LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation. Mol Cell. 2013 Feb 07; 49(3):558-70. PMID: 23260659.
    Citations: 22     Fields:    Translation:HumansCells
  58. Xu Y, Xu C, Kato A, Tempel W, Abreu JG, Bian C, Hu Y, Hu D, Zhao B, Cerovina T, Diao J, Wu F, He HH, Cui Q, Clark E, Ma C, Barbara A, Veenstra GJ, Xu G, Kaiser UB, Liu XS, Sugrue SP, He X, Min J, Kato Y, Shi YG. Tet3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development. Cell. 2012 Dec 07; 151(6):1200-13. PMID: 23217707.
    Citations: 79     Fields:    Translation:AnimalsCells
  59. Tusset C, Noel SD, Trarbach EB, Silveira LF, Jorge AA, Brito VN, Cukier P, Seminara SB, Mendonça BB, Kaiser UB, Latronico AC. Mutational analysis of TAC3 and TACR3 genes in patients with idiopathic central pubertal disorders. Arq Bras Endocrinol Metabol. 2012 Dec; 56(9):646-52. PMID: 23329188.
    Citations: 11     Fields:    Translation:Humans
  60. Babwah AV, Pampillo M, Min L, Kaiser UB, Bhattacharya M. Single-cell analyses reveal that KISS1R-expressing cells undergo sustained kisspeptin-induced signaling that is dependent upon an influx of extracellular Ca2+. Endocrinology. 2012 Dec; 153(12):5875-87. PMID: 23070548.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  61. Kaiser UB. Hyperprolactinemia and infertility: new insights. J Clin Invest. 2012 Oct; 122(10):3467-8. PMID: 23193578.
    Citations: 4     Fields:    
  62. Lian CG, Xu Y, Ceol C, Wu F, Larson A, Dresser K, Xu W, Tan L, Hu Y, Zhan Q, Lee CW, Hu D, Lian BQ, Kleffel S, Yang Y, Neiswender J, Khorasani AJ, Fang R, Lezcano C, Duncan LM, Scolyer RA, Thompson JF, Kakavand H, Houvras Y, Zon LI, Mihm MC, Kaiser UB, Schatton T, Woda BA, Murphy GF, Shi YG. Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma. Cell. 2012 Sep 14; 150(6):1135-46. PMID: 22980977.
    Citations: 218     Fields:    Translation:HumansCells
  63. Gill JC, Navarro VM, Kwong C, Noel SD, Martin C, Xu S, Clifton DK, Carroll RS, Steiner RA, Kaiser UB. Increased neurokinin B (Tac2) expression in the mouse arcuate nucleus is an early marker of pubertal onset with differential sensitivity to sex steroid-negative feedback than Kiss1. Endocrinology. 2012 Oct; 153(10):4883-93. PMID: 22893725.
    Citations: 20     Fields:    Translation:AnimalsCells
  64. Gianetti E, Hall JE, Au MG, Kaiser UB, Quinton R, Stewart JA, Metzger DL, Pitteloud N, Mericq V, Merino PM, Levitsky LL, Izatt L, Lang-Muritano M, Fujimoto VY, Dluhy RG, Chase ML, Crowley WF, Plummer L, Seminara SB. When genetic load does not correlate with phenotypic spectrum: lessons from the GnRH receptor (GNRHR). J Clin Endocrinol Metab. 2012 Sep; 97(9):E1798-807. PMID: 22745237.
    Citations: 10     Fields:    Translation:Humans
  65. Abreu AP, Noel SD, Xu S, Carroll RS, Latronico AC, Kaiser UB. Evidence of the importance of the first intracellular loop of prokineticin receptor 2 in receptor function. Mol Endocrinol. 2012 Aug; 26(8):1417-27. PMID: 22745195.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  66. Chan YM, Broder-Fingert S, Paraschos S, Lapatto R, Au M, Hughes V, Bianco SD, Min L, Plummer L, Cerrato F, De Guillebon A, Wu IH, Wahab F, Dwyer A, Kirsch S, Quinton R, Cheetham T, Ozata M, Ten S, Chanoine JP, Pitteloud N, Martin KA, Schiffmann R, Van der Kamp HJ, Nader S, Hall JE, Kaiser UB, Seminara SB. GnRH-deficient phenotypes in humans and mice with heterozygous variants in KISS1/Kiss1. J Clin Endocrinol Metab. 2011 Nov; 96(11):E1771-81. PMID: 21880801.
    Citations: 19     Fields:    Translation:HumansAnimals
  67. Noel SD, Kaiser UB. G protein-coupled receptors involved in GnRH regulation: molecular insights from human disease. Mol Cell Endocrinol. 2011 Oct 22; 346(1-2):91-101. PMID: 21736917.
    Citations: 12     Fields:    Translation:Humans
  68. Vaidya A, Kaiser UB, Levy BD, Loscalzo J. Clinical problem-solving. Lying low. N Engl J Med. 2011 Mar 03; 364(9):871-5. PMID: 21366479.
    Citations: 1     Fields:    Translation:Humans
  69. Ross JJ, Vaidya A, Kaiser UB. Interactive medical case. Lying low. N Engl J Med. 2011 Feb 10; 364(6):e10. PMID: 21306234.
    Citations: 1     Fields:    Translation:Humans
  70. Bianco SD, Vandepas L, Correa-Medina M, Gereben B, Mukherjee A, Kuohung W, Carroll R, Teles MG, Latronico AC, Kaiser UB. KISS1R intracellular trafficking and degradation: effect of the Arg386Pro disease-associated mutation. Endocrinology. 2011 Apr; 152(4):1616-26. PMID: 21285314.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  71. Martin C, Balasubramanian R, Dwyer AA, Au MG, Sidis Y, Kaiser UB, Seminara SB, Pitteloud N, Zhou QY, Crowley WF. The role of the prokineticin 2 pathway in human reproduction: evidence from the study of human and murine gene mutations. Endocr Rev. 2011 Apr; 32(2):225-46. PMID: 21037178.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  72. Zada G, Tirosh A, Kaiser UB, Laws ER, Woodmansee WW. Cushing's disease and idiopathic intracranial hypertension: case report and review of underlying pathophysiological mechanisms. J Clin Endocrinol Metab. 2010 Nov; 95(11):4850-4. PMID: 20739379.
    Citations: 7     Fields:    Translation:Humans
  73. Gill JC, Wang O, Kakar S, Martinelli E, Carroll RS, Kaiser UB. Reproductive hormone-dependent and -independent contributions to developmental changes in kisspeptin in GnRH-deficient hypogonadal mice. PLoS One. 2010 Jul 30; 5(7):e11911. PMID: 20689830.
    Citations: 32     Fields:    Translation:Animals
  74. Fang R, Barbera AJ, Xu Y, Rutenberg M, Leonor T, Bi Q, Lan F, Mei P, Yuan GC, Lian C, Peng J, Cheng D, Sui G, Kaiser UB, Shi Y, Shi YG. Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation. Mol Cell. 2010 Jul 30; 39(2):222-33. PMID: 20670891.
    Citations: 74     Fields:    Translation:HumansCells
  75. Balasubramanian R, Dwyer A, Seminara SB, Pitteloud N, Kaiser UB, Crowley WF. Human GnRH deficiency: a unique disease model to unravel the ontogeny of GnRH neurons. Neuroendocrinology. 2010; 92(2):81-99. PMID: 20606386.
    Citations: 23     Fields:    Translation:HumansAnimals
  76. Hamnvik OP, Laury AR, Laws ER, Kaiser UB. Lymphocytic hypophysitis with diabetes insipidus in a young man. Nat Rev Endocrinol. 2010 Aug; 6(8):464-70. PMID: 20585348.
    Citations: 6     Fields:    Translation:Humans
  77. Abreu AP, Kaiser UB, Latronico AC. The role of prokineticins in the pathogenesis of hypogonadotropic hypogonadism. Neuroendocrinology. 2010; 91(4):283-90. PMID: 20502053.
    Citations: 8     Fields:    Translation:HumansAnimals
  78. Sykiotis GP, Pitteloud N, Seminara SB, Kaiser UB, Crowley WF. Deciphering genetic disease in the genomic era: the model of GnRH deficiency. Sci Transl Med. 2010 May 19; 2(32):32rv2. PMID: 20484732.
    Citations: 16     Fields:    Translation:HumansAnimals
  79. Kuohung W, Burnett M, Mukhtyar D, Schuman E, Ni J, Crowley WF, Glicksman MA, Kaiser UB. A high-throughput small-molecule ligand screen targeted to agonists and antagonists of the G-protein-coupled receptor GPR54. J Biomol Screen. 2010 Jun; 15(5):508-17. PMID: 20460252.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  80. Teles MG, Trarbach EB, Noel SD, Guerra-Junior G, Jorge A, Beneduzzi D, Bianco SD, Mukherjee A, Baptista MT, Costa EM, De Castro M, Mendonça BB, Kaiser UB, Latronico AC. A novel homozygous splice acceptor site mutation of KISS1R in two siblings with normosmic isolated hypogonadotropic hypogonadism. Eur J Endocrinol. 2010 Jul; 163(1):29-34. PMID: 20371656.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  81. Gianetti E, Tusset C, Noel SD, Au MG, Dwyer AA, Hughes VA, Abreu AP, Carroll J, Trarbach E, Silveira LF, Costa EM, de Mendonça BB, de Castro M, Lofrano A, Hall JE, Bolu E, Ozata M, Quinton R, Amory JK, Stewart SE, Arlt W, Cole TR, Crowley WF, Kaiser UB, Latronico AC, Seminara SB. TAC3/TACR3 mutations reveal preferential activation of gonadotropin-releasing hormone release by neurokinin B in neonatal life followed by reversal in adulthood. J Clin Endocrinol Metab. 2010 Jun; 95(6):2857-67. PMID: 20332248.
    Citations: 79     Fields:    Translation:HumansAnimalsCells
  82. Silveira LG, Noel SD, Silveira-Neto AP, Abreu AP, Brito VN, Santos MG, Bianco SD, Kuohung W, Xu S, Gryngarten M, Escobar ME, Arnhold IJ, Mendonca BB, Kaiser UB, Latronico AC. Mutations of the KISS1 gene in disorders of puberty. J Clin Endocrinol Metab. 2010 May; 95(5):2276-80. PMID: 20237166.
    Citations: 54     Fields:    Translation:Humans
  83. Chamarthi B, Morris CA, Kaiser UB, Katz JT, Loscalzo J. Clinical problem-solving. Stalking the diagnosis. N Engl J Med. 2010 Mar 04; 362(9):834-9. PMID: 20200388.
    Citations: 2     Fields:    Translation:Humans
  84. Ciccone NA, Xu S, Lacza CT, Carroll RS, Kaiser UB. Frequency-dependent regulation of follicle-stimulating hormone beta by pulsatile gonadotropin-releasing hormone is mediated by functional antagonism of bZIP transcription factors. Mol Cell Biol. 2010 Feb; 30(4):1028-40. PMID: 20008557.
    Citations: 30     Fields:    Translation:AnimalsCells
  85. Raivio T, Sidis Y, Plummer L, Chen H, Ma J, Mukherjee A, Jacobson-Dickman E, Quinton R, Van Vliet G, Lavoie H, Hughes VA, Dwyer A, Hayes FJ, Xu S, Sparks S, Kaiser UB, Mohammadi M, Pitteloud N. Frequency of Impaired Fibroblast Growth Factor Receptor 1 Signaling as a Cause of Normosmic Idiopathic Hypogonadotropic Hypogonadism. Endocr Rev. 2009 Dec 01; 30(7):934. PMID: 28199515.
    Citations: 1     Fields:    
  86. Raivio T, Sidis Y, Plummer L, Chen H, Ma J, Mukherjee A, Jacobson-Dickman E, Quinton R, Van Vliet G, Lavoie H, Hughes VA, Dwyer A, Hayes FJ, Xu S, Sparks S, Kaiser UB, Mohammadi M, Pitteloud N. Impaired fibroblast growth factor receptor 1 signaling as a cause of normosmic idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2009 Nov; 94(11):4380-90. PMID: 19820032.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  87. Bianco SD, Kaiser UB. The genetic and molecular basis of idiopathic hypogonadotropic hypogonadism. Nat Rev Endocrinol. 2009 Oct; 5(10):569-76. PMID: 19707180.
    Citations: 62     Fields:    Translation:Humans
  88. Ciccone NA, Kaiser UB. The biology of gonadotroph regulation. Curr Opin Endocrinol Diabetes Obes. 2009 Aug; 16(4):321-7. PMID: 19491666.
    Citations: 22     Fields:    Translation:HumansCells
  89. Jeong KH, Gill JC, Nosé V, Parlow AF, Carroll RS, Kaiser UB. Expression of a gonadotropin-releasing hormone receptor-simian virus 40 T-antigen transgene has sex-specific effects on the reproductive axis. Endocrinology. 2009 Jul; 150(7):3383-91. PMID: 19282386.
    Citations: 1     Fields:    Translation:AnimalsCells
  90. Huebner G, Link H, Kohne CH, Stahl M, Kretzschmar A, Steinbach S, Folprecht G, Bernhard H, Al-Batran SE, Schoffski P, Burkart C, Kullmann F, Otremba B, Menges M, Hoffmann M, Kaiser U, Aldaoud A, Jahn A. Paclitaxel and carboplatin vs gemcitabine and vinorelbine in patients with adeno- or undifferentiated carcinoma of unknown primary: a randomised prospective phase II trial. Br J Cancer. 2009 Jan 13; 100(1):44-9. PMID: 19066607.
    Citations: 11     Fields:    Translation:HumansCTClinical Trials
  91. Ciccone NA, Lacza CT, Hou MY, Gregory SJ, Kam KY, Xu S, Kaiser UB. A composite element that binds basic helix loop helix and basic leucine zipper transcription factors is important for gonadotropin-releasing hormone regulation of the follicle-stimulating hormone beta gene. Mol Endocrinol. 2008 Aug; 22(8):1908-23. PMID: 18550775.
    Citations: 21     Fields:    Translation:AnimalsCells
  92. Kaiser UB. Genetic labeling: new approaches to creating a gonadotroph "ID". Endocrinology. 2008 Jun; 149(6):2699-700. PMID: 18493024.
    Citations:    Fields:    Translation:HumansCells
  93. Gill JC, Wadas B, Chen P, Portillo W, Reyna A, Jorgensen E, Mani S, Schwarting GA, Moenter SM, Tobet S, Kaiser UB. The gonadotropin-releasing hormone (GnRH) neuronal population is normal in size and distribution in GnRH-deficient and GnRH receptor-mutant hypogonadal mice. Endocrinology. 2008 Sep; 149(9):4596-604. PMID: 18499748.
    Citations: 17     Fields:    Translation:AnimalsCells
  94. Teles MG, Bianco SD, Brito VN, Trarbach EB, Kuohung W, Xu S, Seminara SB, Mendonca BB, Kaiser UB, Latronico AC. A GPR54-activating mutation in a patient with central precocious puberty. N Engl J Med. 2008 Feb 14; 358(7):709-15. PMID: 18272894.
    Citations: 107     Fields:    Translation:HumansCells
  95. Bédécarrats GY, Kaiser UB. Mutations in the human gonadotropin-releasing hormone receptor: insights into receptor biology and function. Semin Reprod Med. 2007 Sep; 25(5):368-78. PMID: 17710733.
    Citations: 20     Fields:    Translation:HumansCells
  96. Cogliati T, Delgado-Romero P, Norwitz ER, Guduric-Fuchs J, Kaiser UB, Wray S, Kirsch IR. Pubertal impairment in Nhlh2 null mice is associated with hypothalamic and pituitary deficiencies. Mol Endocrinol. 2007 Dec; 21(12):3013-27. PMID: 17717072.
    Citations: 7     Fields:    Translation:AnimalsCells
  97. Jeong KH, Bakowska JC, Song IO, Fu N, Breakefield XO, Kaiser UB. Improvement in reproductive parameters in hypogonadal female mice by regulated gene replacement therapy in the central nervous system. Gene Ther. 2007 Jul; 14(14):1092-101. PMID: 17476303.
    Citations: 1     Fields:    Translation:AnimalsCells
  98. Sell H, Kaiser U, Eckel J. Expression of chemokine receptors in insulin-resistant human skeletal muscle cells. Horm Metab Res. 2007 Apr; 39(4):244-9. PMID: 17447160.
    Citations: 2     Fields:    Translation:HumansCells
  99. Kuohung W, Kaiser UB. GPR54 and KiSS-1: role in the regulation of puberty and reproduction. Rev Endocr Metab Disord. 2006 Dec; 7(4):257-63. PMID: 17206526.
    Citations: 10     Fields:    Translation:Humans
  100. Boehme V, Zeynalova S, Kloess M, Loeffler M, Kaiser U, Pfreundschuh M, Schmitz N. Incidence and risk factors of central nervous system recurrence in aggressive lymphoma--a survey of 1693 patients treated in protocols of the German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL). Ann Oncol. 2007 Jan; 18(1):149-57. PMID: 17018708.
    Citations: 54     Fields:    Translation:Humans
  101. Chattopadhyay N, Jeong KH, Yano S, Huang S, Pang JL, Ren X, Terwilliger E, Kaiser UB, Vassilev PM, Pollak MR, Brown EM. Calcium receptor stimulates chemotaxis and secretion of MCP-1 in GnRH neurons in vitro: potential impact on reduced GnRH neuron population in CaR-null mice. Am J Physiol Endocrinol Metab. 2007 Feb; 292(2):E523-32. PMID: 17003237.
    Citations: 9     Fields:    Translation:AnimalsCells
  102. Mazhawidza W, Winters SJ, Kaiser UB, Kakar SS. Identification of gene networks modulated by activin in LbetaT2 cells using DNA microarray analysis. Histol Histopathol. 2006 02; 21(2):167-78. PMID: 16329041.
    Citations: 6     Fields:    Translation:AnimalsCells
  103. Kuohung W, Kaiser UB. GPR54 and KiSS-1: Role in the regulation of puberty and reproduction. Reviews in Endocrine and Metabolic Disorders. 2006.
  104. Kanasaki H, Bedecarrats GY, Kam KY, Xu S, Kaiser UB. Gonadotropin-releasing hormone pulse frequency-dependent activation of extracellular signal-regulated kinase pathways in perifused LbetaT2 cells. Endocrinology. 2005 Dec; 146(12):5503-13. PMID: 16141398.
    Citations: 38     Fields:    Translation:AnimalsCells
  105. Kaiser UB, Kuohung W. KiSS-1 and GPR54 as new players in gonadotropin regulation and puberty. Endocrine. 2005 Apr; 26(3):277-84. PMID: 16034182.
    Citations: 14     Fields:    Translation:HumansAnimals
  106. Seminara SB, Kaiser UB. New gatekeepers of reproduction: GPR54 and its cognate ligand, KiSS-1. Endocrinology. 2005 Apr; 146(4):1686-8. PMID: 15769900.
    Citations: 7     Fields:    Translation:Animals
  107. Kuohung W, Kaiser UB. GnRH and gonadotrpins. In Jameson JL and DeGroote, eds. Endocrinology. 2005.
  108. Jeong KH, Kaiser UB. GnRH regulation of gonadotropion biosynthesis and secretion. In: Knobil and Neill, eds. The Physiology of Reproduction. 2005.
  109. Pask AJ, Kanasaki H, Kaiser UB, Conn PM, Janovick JA, Stockton DW, Hess DL, Justice MJ, Behringer RR. A novel mouse model of hypogonadotrophic hypogonadism: N-ethyl-N-nitrosourea-induced gonadotropin-releasing hormone receptor gene mutation. Mol Endocrinol. 2005 Apr; 19(4):972-81. PMID: 15625238.
    Citations: 26     Fields:    Translation:AnimalsCells
  110. Kam KY, Jeong KH, Norwitz ER, Jorgensen EM, Kaiser UB. Oct-1 and nuclear factor Y bind to the SURG-1 element to direct basal and gonadotropin-releasing hormone (GnRH)-stimulated mouse GnRH receptor gene transcription. Mol Endocrinol. 2005 Jan; 19(1):148-62. PMID: 15388790.
    Citations: 15     Fields:    Translation:AnimalsCells
  111. Gregory SJ, Lacza CT, Detz AA, Xu S, Petrillo LA, Kaiser UB. Synergy between activin A and gonadotropin-releasing hormone in transcriptional activation of the rat follicle-stimulating hormone-beta gene. Mol Endocrinol. 2005 Jan; 19(1):237-54. PMID: 15375186.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  112. Gregory SJ, Kaiser UB. Regulation of gonadotropins by inhibin and activin. Semin Reprod Med. 2004 Aug; 22(3):253-67. PMID: 15319828.
    Citations: 35     Fields:    Translation:HumansAnimals
  113. Jeong KH, Chin WW, Kaiser UB. Essential role of the homeodomain for pituitary homeobox 1 activation of mouse gonadotropin-releasing hormone receptor gene expression through interactions with c-Jun and DNA. Mol Cell Biol. 2004 Jul; 24(14):6127-39. PMID: 15226417.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  114. Meysing AU, Kanasaki H, Bedecarrats GY, Acierno JS, Conn PM, Martin KA, Seminara SB, Hall JE, Crowley WF, Kaiser UB. GNRHR mutations in a woman with idiopathic hypogonadotropic hypogonadism highlight the differential sensitivity of luteinizing hormone and follicle-stimulating hormone to gonadotropin-releasing hormone. J Clin Endocrinol Metab. 2004 Jul; 89(7):3189-98. PMID: 15240592.
    Citations: 17     Fields:    Translation:HumansCells
  115. Gregory SJ, Kaiser UB. Regulation of gonadotropins by inhibin and activin. Seminara SB, Kaiser UB. 2004; 22:253-67.
  116. Seminara SB, Messager S, Chatzidaki EE, Thresher RR, Acierno JS, Shagoury JK, Bo-Abbas Y, Kuohung W, Schwinof KM, Hendrick AG, Zahn D, Dixon J, Kaiser UB, Slaugenhaupt SA, Gusella JF, O'Rahilly S, Carlton MB, Crowley WF, Aparicio SA, Colledge WH. The GPR54 gene as a regulator of puberty. N Engl J Med. 2003 Oct 23; 349(17):1614-27. PMID: 14573733.
    Citations: 573     Fields:    Translation:HumansAnimals
  117. Kaiser UB. The pathogenesis of the ovarian hyperstimulation syndrome. N Engl J Med. 2003 Aug 21; 349(8):729-32. PMID: 12930924.
    Citations: 11     Fields:    Translation:Humans
  118. Bédécarrats GY, Linher KD, Janovick JA, Beranova M, Kada F, Seminara SB, Michael Conn P, Kaiser UB. Four naturally occurring mutations in the human GnRH receptor affect ligand binding and receptor function. Mol Cell Endocrinol. 2003 Jul 31; 205(1-2):51-64. PMID: 12890567.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  119. Bédécarrats GY, O'Neill FH, Norwitz ER, Kaiser UB, Teixeira J. Regulation of gonadotropin gene expression by Mullerian inhibiting substance. Proc Natl Acad Sci U S A. 2003 Aug 05; 100(16):9348-53. PMID: 12878721.
    Citations: 10     Fields:    Translation:AnimalsCells
  120. Bédécarrats GY, Kaiser UB. Differential regulation of gonadotropin subunit gene promoter activity by pulsatile gonadotropin-releasing hormone (GnRH) in perifused L beta T2 cells: role of GnRH receptor concentration. Endocrinology. 2003 May; 144(5):1802-11. PMID: 12697686.
    Citations: 38     Fields:    Translation:AnimalsCells
  121. Bedecarrats GY, Linher KD, Kaiser UB. Two common naturally occurring mutations in the human gonadotropin-releasing hormone (GnRH) receptor have differential effects on gonadotropin gene expression and on GnRH-mediated signal transduction. J Clin Endocrinol Metab. 2003 Feb; 88(2):834-43. PMID: 12574221.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  122. Kaiser UB. Perspective: Pathogenesis of ovarian hyperstimulation syndrome: insights from FSH receptor mutations. New Engl J Med. 2003; 349:729-32.
  123. Zakaria MM, Jeong KH, Lacza C, Kaiser UB. Pituitary homeobox 1 activates the rat FSHbeta (rFSHbeta) gene through both direct and indirect interactions with the rFSHbeta gene promoter. Mol Endocrinol. 2002 Aug; 16(8):1840-52. PMID: 12145338.
    Citations: 16     Fields:    Translation:AnimalsCells
  124. Norwitz ER, Xu S, Xu J, Spiryda LB, Park JS, Jeong KH, McGee EA, Kaiser UB. Direct binding of AP-1 (Fos/Jun) proteins to a SMAD binding element facilitates both gonadotropin-releasing hormone (GnRH)- and activin-mediated transcriptional activation of the mouse GnRH receptor gene. J Biol Chem. 2002 Oct 04; 277(40):37469-78. PMID: 12145309.
    Citations: 22     Fields:    Translation:AnimalsCells
  125. Norwitz ER, Xu S, Jeong KH, Bédécarrats GY, Winebrenner LD, Chin WW, Kaiser UB. Activin A augments GnRH-mediated transcriptional activation of the mouse GnRH receptor gene. Endocrinology. 2002 Mar; 143(3):985-97. PMID: 11861523.
    Citations: 18     Fields:    Translation:AnimalsCells
  126. Norwitz ER, Xu S, Jeong KH, Be de Carrats GG, Winebrenner LD, Chin WW, Kaiser UB. Activin A Augments GnRH-Mediated Transcriptional Activation of the Mouse GnRH Receptor Gene. Endocrinology. 2002 Mar 01; 143(3):985-997. PMID: 28204468.
    Citations:    
  127. Costa EM, Bedecarrats GY, Mendonca BB, Arnhold IJ, Kaiser UB, Latronico AC. Two novel mutations in the gonadotropin-releasing hormone receptor gene in Brazilian patients with hypogonadotropic hypogonadism and normal olfaction. J Clin Endocrinol Metab. 2001 Jun; 86(6):2680-6. PMID: 11397871.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  128. Beranova M, Oliveira LM, Bédécarrats GY, Schipani E, Vallejo M, Ammini AC, Quintos JB, Hall JE, Martin KA, Hayes FJ, Pitteloud N, Kaiser UB, Crowley WF, Seminara SB. Prevalence, phenotypic spectrum, and modes of inheritance of gonadotropin-releasing hormone receptor mutations in idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2001 Apr; 86(4):1580-8. PMID: 11297587.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  129. Kaiser U. Pituitary gene therapy--hypotheses on the hypophysis. Endocrinology. 2001 Feb; 142(2):528-31. PMID: 11159820.
    Citations:    Fields:    Translation:HumansAnimalsCells
  130. Kaiser UB. Editorial: Pituitary Gene Therapy-Hypotheses on the Hypophysis. Endocrinology. 2001 Feb 01; 142(2):528-531. PMID: 28201234.
    Citations:    
  131. Kaiser UB, Hedley-Whyte ET. Weekly clinicopathological excerises: Case 15-2001: A 72-year old man with persistent fever and hypotension. New Engl J Med. 2001; 344:1536-42.
  132. Kaiser UB, Halvorson LM, Chen MT. Sp1, steroidogenic factor 1 (SF-1), and early growth response protein 1 (egr-1) binding sites form a tripartite gonadotropin-releasing hormone response element in the rat luteinizing hormone-beta gene promoter: an integral role for SF-1. Mol Endocrinol. 2000 Aug; 14(8):1235-45. PMID: 10935547.
    Citations: 38     Fields:    Translation:AnimalsCells
  133. Kaiser UB. Neuroendocrinology: editorial overview. Curr Opin Endocrinol and Diab. 2000; 7:151-2.
  134. Kaiser U, Uebelacker I, Havemann K. Non-Hodgkin's lymphoma protocols in the treatment of patients with Burkitt's lymphoma and lymphoblastic lymphoma: a report on 58 patients. Leuk Lymphoma. 1999 Dec; 36(1-2):101-8. PMID: 10613454.
    Citations: 5     Fields:    Translation:Humans
  135. Kaiser U, Weide R, Wolf M. Successful salvage treatment for relapse after autologous stem cell transplantation in a patient with Hodgkin's disease--a case report. Ann Hematol. 1999 Jan; 78(1):33-5. PMID: 10037267.
    Citations:    Fields:    Translation:Humans
  136. Halvorson LM, Kaiser UB, Chin WW. The protein kinase C system acts through the early growth response protein 1 to increase LHbeta gene expression in synergy with steroidogenic factor-1. Mol Endocrinol. 1999 Jan; 13(1):106-16. PMID: 9892016.
    Citations: 17     Fields:    Translation:AnimalsCells
  137. Kaiser UB. Molecular mechanisms of the regulation of gonadotropin gene expression by gonadotropin-releasing hormone. Mol Cells. 1998 Dec 31; 8(6):647-56. PMID: 9895115.
    Citations: 1     Fields:    Translation:HumansAnimals
  138. Mitsumori M, Shrieve DC, Alexander E, Kaiser UB, Richardson GE, Black PM, Loeffler JS. Initial clinical results of LINAC-based stereotactic radiosurgery and stereotactic radiotherapy for pituitary adenomas. Int J Radiat Oncol Biol Phys. 1998 Oct 01; 42(3):573-80. PMID: 9806517.
    Citations: 29     Fields:    Translation:Humans
  139. Kaiser UB, Sabbagh E, Chen MT, Chin WW, Saunders BD. Sp1 binds to the rat luteinizing hormone beta (LHbeta) gene promoter and mediates gonadotropin-releasing hormone-stimulated expression of the LHbeta subunit gene. J Biol Chem. 1998 May 22; 273(21):12943-51. PMID: 9582327.
    Citations: 9     Fields:    Translation:AnimalsCells
  140. Kaiser UB, Sabbagh E, Saunders BD, Chin WW. Identification of cis-acting deoxyribonucleic acid elements that mediate gonadotropin-releasing hormone stimulation of the rat luteinizing hormone beta-subunit gene. Endocrinology. 1998 May; 139(5):2443-51. PMID: 9564856.
    Citations: 3     Fields:    Translation:AnimalsCells
  141. Hiddemann W, Unterhalt M, Herrmann R, Wöltjen HH, Kreuser ED, Trümper L, Reuss-Borst M, Terhardt-Kasten E, Busch M, Neubauer A, Kaiser U, Hanrath RD, Middeke H, Helm G, Freund M, Stein H, Tiemann M, Parwaresch R. Mantle-cell lymphomas have more widespread disease and a slower response to chemotherapy compared with follicle-center lymphomas: results of a prospective comparative analysis of the German Low-Grade Lymphoma Study Group. J Clin Oncol. 1998 May; 16(5):1922-30. PMID: 9586911.
    Citations: 14     Fields:    Translation:HumansCTClinical Trials
  142. Kaiser UB, Sabbagh E, Saunders BD, Chin WW. Identification of cis-Acting Deoxyribonucleic Acid Elements That Mediate Gonadotropin-Releasing Hormone Stimulation of the Rat Luteinizing Hormone ß-Subunit Gene. Endocrinology. 1998 May 01; 139(5):2443-2451. PMID: 28200605.
    Citations:    
  143. Saunders BD, Sabbagh E, Chin WW, Kaiser UB. Differential use of signal transduction pathways in the gonadotropin-releasing hormone-mediated regulation of gonadotropin subunit gene expression. Endocrinology. 1998 Apr; 139(4):1835-43. PMID: 9528969.
    Citations: 13     Fields:    Translation:AnimalsCells
  144. Mitsumori M, Shrieve DC, Alexander K, Kaiser UB, Richardson GE, Black PM, Loeffler JS. Initial clinical results of LINAC-based stereotactic radiosurgery and sterostatic radiotherapy for pituitary ademomas. Int J Radiation Oncology Biol Phys. 1998; 42:573-80.
  145. Kaiser UB, Jakubowiak A, Steinberger A, Chin WW. Differential effects of gonadotropin-releasing hormone (GnRH) pulse frequency on gonadotropin subunit and GnRH receptor messenger ribonucleic acid levels in vitro. Endocrinology. 1997 Mar; 138(3):1224-31. PMID: 9048630.
    Citations: 52     Fields:    Translation:AnimalsCells
  146. Wimmel A, Schilli M, Kaiser U, Havemann K, Ramaswamy A, Branscheid D, Kogan E, Schuermann M. Preferential histiotypic expression of CD44-isoforms in human lung cancer. Lung Cancer. 1997 Mar; 16(2-3):151-72. PMID: 9152947.
    Citations: 2     Fields:    Translation:HumansCells
  147. Kaiser UB, Conn PM, Chin WW. Studies of gonadotropin-releasing hormone (GnRH) action using GnRH receptor-expressing pituitary cell lines. Endocr Rev. 1997 Feb; 18(1):46-70. PMID: 9034786.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  148. Kaiser UB, Jakubowiak A, Steinberger A, Chin WW. Differential effects of gonaadotropin-releasing hormone pulse frequency on gonadotropin subunit and gonadotropin-releasing hormone receptor mRNA levels in vitro. Endocrinology. 1997; 138:1224-31.
  149. Penabad JL, Bashey HM, Asa SL, Haddad G, Davis KD, Herbst AB, Gennarelli TA, Kaiser UB, Chin WW, Snyder PJ. Decreased follistatin gene expression in gonadotroph adenomas. J Clin Endocrinol Metab. 1996 Sep; 81(9):3397-403. PMID: 8784103.
    Citations: 2     Fields:    Translation:HumansCells
  150. Kaiser U, Schilli M, Haag U, Neumann K, Kreipe H, Kogan E, Havemann K. Expression of bcl-2--protein in small cell lung cancer. Lung Cancer. 1996 Aug; 15(1):31-40. PMID: 8865121.
    Citations: 17     Fields:    Translation:Humans
  151. Kaiser U, Hofmann J, Schilli M, Wegmann B, Klotz U, Wedel S, Virmani AK, Wollmer E, Branscheid D, Gazdar AF, Havemann K. Steroid-hormone receptors in cell lines and tumor biopsies of human lung cancer. Int J Cancer. 1996 Jul 29; 67(3):357-64. PMID: 8707409.
    Citations: 28     Fields:    Translation:HumansCells
  152. Fernández-Vázquez G, Kaiser UB, Albarracin CT, Chin WW. Transcriptional activation of the gonadotropin-releasing hormone receptor gene by activin A. Mol Endocrinol. 1996 Apr; 10(4):356-66. PMID: 8721981.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  153. Halvorson LM, Kaiser UB, Chin WW. Stimulation of luteinizing hormone beta gene promoter activity by the orphan nuclear receptor, steroidogenic factor-1. J Biol Chem. 1996 Mar 22; 271(12):6645-50. PMID: 8636081.
    Citations: 32     Fields:    Translation:AnimalsCells
  154. Stricker H, Kaiser U, Frei J, Mahler F. Acute and long-term effects of prostaglandin E1 assessed by clinical and microcirculatory parameters in critical limb ischemia: a pilot study. Int J Microcirc Clin Exp. 1996 Mar-Apr; 16(2):57-63. PMID: 8737708.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  155. Ong F, Kaiser U, Seelen PJ, Hermans J, Wijermans PW, de Kieviet W, Jaques G, Kluin-Nelemans JC. Serum neural cell adhesion molecule differentiates multiple myeloma from paraproteinemias due to other causes. Blood. 1996 Jan 15; 87(2):712-6. PMID: 8555495.
    Citations: 2     Fields:    Translation:Humans
  156. Kaiser UB, Sabbagh E, Katzenellenbogen RA, Conn PM, Chin WW. A mechanism for the differential regulation of gonadotropin subunit gene expression by gonadotropin-releasing hormone. Proc Natl Acad Sci U S A. 1995 Dec 19; 92(26):12280-4. PMID: 8618885.
    Citations: 33     Fields:    Translation:AnimalsCells
  157. Soufi M, Kaiser U, Schneider A, Beato M, Westphal HM. The DNA and steroid binding domains of the glucocorticoid receptor are not altered in mononuclear cells of treated CLL patients. Exp Clin Endocrinol Diabetes. 1995; 103(3):175-83. PMID: 7584520.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  158. Kaiser UB, Sabbagh E, Katzenellenbogen RA, Conn PM, Chin WW. A mechanism for the differential regulation of gonadoropins by gonadotropin-releasing hormone. Proc Natl Acad Science USA. 1995; 92:12280-4.
  159. Albarracin CT, Kaiser UB, Chin WW. Isolation and characterization of the 5'-flanking region of the mouse gonadotropin-releasing hormone receptor gene. Endocrinology. 1994 Dec; 135(6):2300-6. PMID: 7988412.
    Citations: 15     Fields:    Translation:AnimalsCells
  160. Stanislaus D, Janovick JA, Jennes L, Kaiser UB, Chin WW, Conn PM. Functional and morphological characterization of four cell lines derived from GH3 cells stably transfected with gonadotropin-releasing hormone receptor complementary deoxyribonucleic acid. Endocrinology. 1994 Nov; 135(5):2220-7. PMID: 7956945.
    Citations: 6     Fields:    Translation:AnimalsCells
  161. Kaiser UB, Katzenellenbogen RA, Conn PM, Chin WW. Evidence that signalling pathways by which thyrotropin-releasing hormone and gonadotropin-releasing hormone act are both common and distinct. Mol Endocrinol. 1994 Aug; 8(8):1038-48. PMID: 7527898.
    Citations: 3     Fields:    Translation:AnimalsCells
  162. Kuphal D, Janovick JA, Kaiser UB, Chin WW, Conn PM. Stable transfection of GH3 cells with rat gonadotropin-releasing hormone receptor complementary deoxyribonucleic acid results in expression of a receptor coupled to cyclic adenosine 3',5'-monophosphate-dependent prolactin release via a G-protein. Endocrinology. 1994 Jul; 135(1):315-20. PMID: 8013367.
    Citations: 6     Fields:    Translation:AnimalsCells
  163. Kaiser UB, Dushkin H, Altherr MR, Beier DR, Chin WW. Chromosomal localization of the gonadotropin-releasing hormone receptor gene to human chromosome 4q13.1-q21.1 and mouse chromosome 5. Genomics. 1994 Apr; 20(3):506-8. PMID: 8034328.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  164. Kuphal D, Janovick J, Kaiser UB, Chin WW, Conn PM. Stable transfection of GH3 cells with rat GnRH receptor cDNA results in expression of a receptor which is coupled to cyclic AMP-dependent prolactin release via a G protein. Endocrinology. 1994; 135:315-20.
  165. Kaiser UB, Jakubowiak A, Steinberger A, Chin WW. Regulation of rat pituitary gonadotropin-releasing hormone receptor mRNA levels in vivo and in vitro. Endocrinology. 1993 Aug; 133(2):931-4. PMID: 8393779.
    Citations: 42     Fields:    Translation:AnimalsCells
  166. Kaiser UB, Chin WW. Regulation of follistatin messenger ribonucleic acid levels in the rat pituitary. J Clin Invest. 1993 Jun; 91(6):2523-31. PMID: 8514864.
    Citations: 7     Fields:    Translation:AnimalsCells
  167. Kaiser UB, Zhao D, Cardona GR, Chin WW. Isolation and characterization of cDNAs encoding the rat pituitary gonadotropin-releasing hormone receptor. Biochem Biophys Res Commun. 1992 Dec 30; 189(3):1645-52. PMID: 1339279.
    Citations: 20     Fields:    Translation:AnimalsCells
  168. Kaiser UB, Lee BL, Carroll RS, Unabia G, Chin WW, Childs GV. Follistatin gene expression in the pituitary: localization in gonadotropes and folliculostellate cells in diestrous rats. Endocrinology. 1992 May; 130(5):3048-56. PMID: 1572312.
    Citations: 25     Fields:    Translation:AnimalsCells
  169. Kaiser UB, Ethier JH, Kamel KS, Halperin ML. Persistent hyperkalemia in a patient with diabetes mellitus: a reversible defect in kaliuresis during bicarbonaturia. Clin Invest Med. 1992 Apr; 15(2):187-93. PMID: 1591899.
    Citations:    Fields:    Translation:Humans
  170. Jaques G, Kiefer P, Schöneberger HJ, Wegmann B, Kaiser U, Brandscheid D, Havemann K. Differential expression of insulin-like growth factor binding proteins in human non-small cell lung cancer cell lines. Eur J Cancer. 1992; 28A(11):1899-904. PMID: 1382500.
    Citations: 3     Fields:    Translation:HumansCells
  171. Kaiser UB, Ethier JH, Kamel KS, Halperin ML. Presistent hyperkalemia in a patient with diabetes mellitus:; Presumptive evidence for a chloride shunt type of disorder. Clin Invest Med. 1992; 15:187-93.
  172. Kaiser UB, Hegele RA. Case report: heterogeneity of aldolase B in hereditary fructose intolerance. Am J Med Sci. 1991 Dec; 302(6):364-8. PMID: 1772121.
    Citations:    Fields:    Translation:HumansCells
  173. Carlisle EJ, Donnelly SM, Ethier JH, Quaggin SE, Kaiser UB, Vasuvattakul S, Kamel KS, Halperin ML. Modulation of the secretion of potassium by accompanying anions in humans. Kidney Int. 1991 Jun; 39(6):1206-12. PMID: 1895674.
    Citations: 6     Fields:    Translation:HumansCells
  174. Sauerbrei A, Wutzler P, Pfister W, Kaiser U, Schreiber D, Rüdiger KD. [Microbiological and morphological findings in reactive lymphadenopathy]. Zentralbl Allg Pathol. 1990; 136(5):419-25. PMID: 2173296.
    Citations:    Fields:    Translation:HumansAnimalsCells
  175. Albrecht S, Gardiner GW, Kovacs K, Ilse G, Kaiser U. Duodenal somatostatinoma with psammoma bodies. Arch Pathol Lab Med. 1989 May; 113(5):517-20. PMID: 2565711.
    Citations:    Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.