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Pia Kivisakk Webb, Ph.D., M.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Al Ali J, Vaine CA, Shah S, Campion L, Hakoum A, Supnet ML, Acuña P, Aldykiewicz G, Multhaupt-Buell T, Ganza NGM, Lagarde JBB, De Guzman JK, Go C, Currall B, Trombetta B, Webb PK, Talkowski M, Arnold SE, Cheah PS, Ito N, Sharma N, Bragg DC, Ozelius L, Breakefield XO. TAF1 Transcripts and Neurofilament Light Chain as Biomarkers for X-Linked Dystonia-Parkinsonism. Mov Disord. 2020 Sep 25. PMID: 32975318.
    Citations:    Fields:    
  2. Raheja R, Regev K, Healy BC, Mazzola MA, Beynon V, Von Glehn F, Paul A, Diaz-Cruz C, Gholipour T, Glanz BI, Kivisakk P, Chitnis T, Weiner HL, Berry JD, Gandhi R. Correlating serum micrornas and clinical parameters in amyotrophic lateral sclerosis. Muscle Nerve. 2018 Aug; 58(2):261-269. PMID: 29466830.
    Citations: 17     Fields:    Translation:Humans
  3. Tankou SK, Regev K, Healy BC, Cox LM, Tjon E, Kivisakk P, Vanande IP, Cook S, Gandhi R, Glanz B, Stankiewicz J, Weiner HL. Investigation of probiotics in multiple sclerosis. Mult Scler. 2018 01; 24(1):58-63. PMID: 29307299.
    Citations: 16     Fields:    Translation:HumansCellsCTClinical Trials
  4. Hu D, Notarbartolo S, Croonenborghs T, Patel B, Cialic R, Yang TH, Aschenbrenner D, Andersson KM, Gattorno M, Pham M, Kivisakk P, Pierre IV, Lee Y, Kiani K, Bokarewa M, Tjon E, Pochet N, Sallusto F, Kuchroo VK, Weiner HL. Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis. Nat Commun. 2017 11 17; 8(1):1600. PMID: 29150604.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  5. Mazzola MA, Raheja R, Regev K, Beynon V, von Glehn F, Paul A, Pierre I, Kivisakk P, Weiner HL, Gandhi R. Monomethyl fumarate treatment impairs maturation of human myeloid dendritic cells and their ability to activate T cells. Mult Scler. 2019 01; 25(1):63-71. PMID: 29106333.
    Citations: 5     Fields:    Translation:HumansCells
  6. Regev K, Healy BC, Khalid F, Paul A, Chu R, Tauhid S, Tummala S, Diaz-Cruz C, Raheja R, Mazzola MA, von Glehn F, Kivisakk P, Dupuy SL, Kim G, Chitnis T, Weiner HL, Gandhi R, Bakshi R. Association Between Serum MicroRNAs and Magnetic Resonance Imaging Measures of Multiple Sclerosis Severity. JAMA Neurol. 2017 03 01; 74(3):275-285. PMID: 28114622.
    Citations: 10     Fields:    Translation:Humans
  7. Regev K, Paul A, Healy B, von Glenn F, Diaz-Cruz C, Gholipour T, Mazzola MA, Raheja R, Nejad P, Glanz BI, Kivisakk P, Chitnis T, Weiner HL, Gandhi R. Comprehensive evaluation of serum microRNAs as biomarkers in multiple sclerosis. Neurol Neuroimmunol Neuroinflamm. 2016 Oct; 3(5):e267. PMID: 27606352.
    Citations: 15     Fields:    
  8. Mazzola MA, Raheja R, Murugaiyan G, Rajabi H, Kumar D, Pertel T, Regev K, Griffin R, Aly L, Kivisakk P, Nejad P, Patel B, Gwanyalla N, Hei H, Glanz B, Chitnis T, Weiner HL, Gandhi R. Identification of a novel mechanism of action of fingolimod (FTY720) on human effector T cell function through TCF-1 upregulation. J Neuroinflammation. 2015 Dec 30; 12:245. PMID: 26714756.
    Citations: 7     Fields:    Translation:HumansCells
  9. Rotstein DL, Healy BC, Malik MT, Carruthers RL, Musallam AJ, Kivisakk P, Weiner HL, Glanz B, Chitnis T. Effect of vitamin D on MS activity by disease-modifying therapy class. Neurol Neuroimmunol Neuroinflamm. 2015 Dec; 2(6):e167. PMID: 26568968.
    Citations: 10     Fields:    
  10. Malik MT, Healy BC, Benson LA, Kivisakk P, Musallam A, Weiner HL, Chitnis T. Factors associated with recovery from acute optic neuritis in patients with multiple sclerosis. Neurology. 2014 Jun 17; 82(24):2173-9. PMID: 24850491.
    Citations: 8     Fields:    Translation:Humans
  11. Messina S, Vargas-Lowy D, Musallam A, Healy BC, Kivisakk P, Gandhi R, Bove R, Gholipour T, Khoury S, Weiner HL, Chitnis T. Increased leptin and A-FABP levels in relapsing and progressive forms of MS. BMC Neurol. 2013 Nov 11; 13:172. PMID: 24215402.
    Citations: 4     Fields:    Translation:Humans
  12. Gandhi R, Healy B, Gholipour T, Egorova S, Musallam A, Hussain MS, Nejad P, Patel B, Hei H, Khoury S, Quintana F, Kivisakk P, Chitnis T, Weiner HL. Circulating microRNAs as biomarkers for disease staging in multiple sclerosis. Ann Neurol. 2013 Jun; 73(6):729-40. PMID: 23494648.
    Citations: 70     Fields:    Translation:Humans
  13. Ilan Y, Zigmond E, Lalazar G, Dembinsky A, Ben Ya'acov A, Hemed N, Kasis I, Axelrod E, Zolotarov L, Klein A, El Haj M, Gandhi R, Baecher-Allan C, Wu H, Murugaiyan G, Kivisakk P, Farez MF, Quintana FJ, Khoury SJ, Weiner HL. Oral administration of OKT3 monoclonal antibody to human subjects induces a dose-dependent immunologic effect in T cells and dendritic cells. J Clin Immunol. 2010 Jan; 30(1):167-77. PMID: 19756989.
    Citations: 24     Fields:    Translation:HumansCellsCTClinical Trials
  14. Fox RJ, Kivisakk P, Fisher E, Tucky B, Lee JC, Rudick RA, Ransohoff RM. Multiple sclerosis: chemokine receptor expression on circulating lymphocytes in correlation with radiographic measures of tissue injury. Mult Scler. 2008 Sep; 14(8):1036-43. PMID: 18701575.
    Citations: 4     Fields:    Translation:HumansCells
  15. Kivisäkk P, Tucky B, Wei T, Campbell JJ, Ransohoff RM. Human cerebrospinal fluid contains CD4+ memory T cells expressing gut- or skin-specific trafficking determinants: relevance for immunotherapy. BMC Immunol. 2006 Jul 07; 7:14. PMID: 16824229.
    Citations: 17     Fields:    Translation:HumansCells
  16. Baekkevold ES, Wurbel MA, Kivisäkk P, Wain C, Power CA, Haraldsen G, Campbell JJ. Competitive adoptive transfer model reveals a role for CCR4 in development of mature circulating cutaneous Th memory populations. J Exp Med. 2005; In press.
  17. Callahan MK, Williams KA, Kivisäkk P, Pearce D, Stins MF, Ransohoff RM. CXCR3 marks CD4+ memory T lymphocytes that are competent to migrate across a human brain microvascular endothelial cell layer. J Neuroimmunol. 2004 Aug; 153(1-2):150-7. PMID: 15265673.
    Citations: 24     Fields:    Translation:HumansCells
  18. Kivisäkk P, Mahad DJ, Callahan MK, Sikora K, Trebst C, Tucky B, Wujek J, Ravid R, Staugaitis SM, Lassmann H, Ransohoff RM. Expression of CCR7 in multiple sclerosis: implications for CNS immunity. Ann Neurol. 2004 May; 55(5):627-38. PMID: 15122702.
    Citations: 84     Fields:    Translation:Humans
  19. Mahad DJ, Trebst C, Kivisäkk P, Staugaitis SM, Tucky B, Wei T, Lucchinetti CF, Lassmann H, Ransohoff RM. Expression of chemokine receptors CCR1 and CCR5 reflects differential activation of mononuclear phagocytes in pattern II and pattern III multiple sclerosis lesions. J Neuropathol Exp Neurol. 2004 Mar; 63(3):262-73. PMID: 15055450.
    Citations: 21     Fields:    Translation:HumansCells
  20. Mahad D, Trebst C, Staugaitis SM, Kivisäkk P, Tucky B, Wei T, Horuk R, Ransohoff RM. Preliminary observations on CC chemokine receptor expression by mononuclear phagocytes in multiple sclerosis lesions: effect of lesion heterogeneity. Ernst Schering Res Found Workshop. 2004; (45):59-68. PMID: 14699794.
    Citations:    Fields:    Translation:HumansCells
  21. Putheti P, Morris M, Stawiarz L, Teleshova N, Kivisäkk P, Pashenkov M, Kouwenhoven M, Wiberg MK, Bronge L, Huang YM, Söderström M, Hillert J, Link H. Multiple sclerosis: a study of chemokine receptors and regulatory T cells in relation to MRI variables. Eur J Neurol. 2003 Sep; 10(5):529-35. PMID: 12940835.
    Citations: 11     Fields:    Translation:HumansCells
  22. Kivisäkk P, Cotleur AC, Lee JC, Rudick RA, Ransohoff RM. Interferon-beta 1a does not reduce expression of CCR5 and CXCR3 on circulating T cells. J Neuroimmunol. 2003 Aug; 141(1-2):150-4. PMID: 12965266.
    Citations: 1     Fields:    Translation:HumansCellsCTClinical Trials
  23. Ransohoff RM, Kivisäkk P, Kidd G. Three or more routes for leukocyte migration into the central nervous system. Nat Rev Immunol. 2003 Jul; 3(7):569-81. PMID: 12876559.
    Citations: 320     Fields:    Translation:HumansAnimalsCells
  24. Kivisäkk P, Mahad DJ, Callahan MK, Trebst C, Tucky B, Wei T, Wu L, Baekkevold ES, Lassmann H, Staugaitis SM, Campbell JJ, Ransohoff RM. Human cerebrospinal fluid central memory CD4+ T cells: evidence for trafficking through choroid plexus and meninges via P-selectin. Proc Natl Acad Sci U S A. 2003 Jul 08; 100(14):8389-94. PMID: 12829791.
    Citations: 141     Fields:    Translation:HumansCells
  25. Kivisäkk P, Trebst C, Lee JC, Tucky BH, Rudick RA, Campbell JJ, Ransohoff RM. Expression of CCR2, CCR5, and CXCR3 by CD4+ T cells is stable during a 2-year longitudinal study but varies widely between individuals. J Neurovirol. 2003 Jun; 9(3):291-9. PMID: 12775413.
    Citations: 4     Fields:    Translation:HumansCells
  26. Kivisäkk P, Liu Z, Trebst C, Tucky B, Wu L, Stine J, Mack M, Rudick RA, Campbell JJ, Ransohoff RM. Flow cytometric analysis of chemokine receptor expression on cerebrospinal fluid leukocytes. Methods. 2003 Apr; 29(4):319-25. PMID: 12725798.
    Citations: 7     Fields:    Translation:HumansCells
  27. Trebst C, Staugaitis SM, Kivisäkk P, Mahad D, Cathcart MK, Tucky B, Wei T, Rani MR, Horuk R, Aldape KD, Pardo CA, Lucchinetti CF, Lassmann H, Ransohoff RM. CC chemokine receptor 8 in the central nervous system is associated with phagocytic macrophages. Am J Pathol. 2003 Feb; 162(2):427-38. PMID: 12547701.
    Citations: 14     Fields:    Translation:HumansCells
  28. Kivisäkk P, Trebst C, Liu Z, Tucky BH, Sørensen TL, Rudick RA, Mack M, Ransohoff RM. T-cells in the cerebrospinal fluid express a similar repertoire of inflammatory chemokine receptors in the absence or presence of CNS inflammation: implications for CNS trafficking. Clin Exp Immunol. 2002 Sep; 129(3):510-8. PMID: 12197893.
    Citations: 35     Fields:    Translation:HumansCells
  29. Sørensen TL, Trebst C, Kivisäkk P, Klaege KL, Majmudar A, Ravid R, Lassmann H, Olsen DB, Strieter RM, Ransohoff RM, Sellebjerg F. Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system. J Neuroimmunol. 2002 Jun; 127(1-2):59-68. PMID: 12044976.
    Citations: 42     Fields:    Translation:HumansCells
  30. Teleshova N, Pashenkov M, Huang YM, Söderström M, Kivisäkk P, Kostulas V, Haglund M, Link H. Multiple sclerosis and optic neuritis: CCR5 and CXCR3 expressing T cells are augmented in blood and cerebrospinal fluid. J Neurol. 2002 Jun; 249(6):723-9. PMID: 12111306.
    Citations: 17     Fields:    Translation:HumansCells
  31. Trebst C, Sørensen TL, Kivisäkk P, Cathcart MK, Hesselgesser J, Horuk R, Sellebjerg F, Lassmann H, Ransohoff RM. Chemokine receptors on mononuclear phagocytes in the central nervous system of patients with multiple sclerosis. Ernst Schering Res Found Workshop. 2002; (39):193-211. PMID: 12066413.
    Citations:    Fields:    Translation:HumansCells
  32. Kivisäkk P, Trebst C, Eckstein DJ, Kerza-Kwiatecki AP, Ransohoff RM. Chemokine-based therapies for MS: how do we get there from here? Trends Immunol. 2001 Nov; 22(11):591-3. PMID: 11698200.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  33. Trebst C, Sørensen TL, Kivisäkk P, Cathcart MK, Hesselgesser J, Horuk R, Sellebjerg F, Lassmann H, Ransohoff RM. CCR1+/CCR5+ mononuclear phagocytes accumulate in the central nervous system of patients with multiple sclerosis. Am J Pathol. 2001 Nov; 159(5):1701-10. PMID: 11696431.
    Citations: 61     Fields:    Translation:HumansCells
  34. Huang DR, Wang J, Kivisakk P, Rollins BJ, Ransohoff RM. Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis. J Exp Med. 2001 Mar 19; 193(6):713-26. PMID: 11257138.
    Citations: 179     Fields:    Translation:AnimalsCells
  35. Teleshova N, Matusevicius D, Kivisäkk P, Mustafa M, Pirskanen R, Link H. Altered expression of costimulatory molecules in myasthenia gravis. Muscle Nerve. 2000 Jun; 23(6):946-53. PMID: 10842273.
    Citations: 2     Fields:    Translation:HumansCells
  36. Ozenci V, Kouwenhoven M, Huang YM, Kivisäkk P, Link H. Multiple sclerosis is associated with an imbalance between tumour necrosis factor-alpha (TNF-alpha)- and IL-10-secreting blood cells that is corrected by interferon-beta (IFN-beta) treatment. Clin Exp Immunol. 2000 Apr; 120(1):147-53. PMID: 10759776.
    Citations: 23     Fields:    Translation:HumansCells
  37. Teleshova N, Bao W, Kivisäkk P, Ozenci V, Mustafa M, Link H. Elevated CD40 ligand expressing blood T-cell levels in multiple sclerosis are reversed by interferon-beta treatment. Scand J Immunol. 2000 Mar; 51(3):312-20. PMID: 10736102.
    Citations: 10     Fields:    Translation:HumansCells
  38. Helms G, Stawiarz L, Kivisäkk P, Link H. Regression analysis of metabolite concentrations estimated from localized proton MR spectra of active and chronic multiple sclerosis lesions. Magn Reson Med. 2000 Jan; 43(1):102-10. PMID: 10642736.
    Citations: 8     Fields:    Translation:HumansCTClinical Trials
  39. Huang YM, Kivisäkk P, Ozenci V, Pirskanen R, Link H. Increased levels of circulating acetylcholine receptor (AChR)-reactive IL-10-secreting cells are characteristic for myasthenia gravis (MG). Clin Exp Immunol. 1999 Nov; 118(2):304-8. PMID: 10540195.
    Citations: 4     Fields:    Translation:HumansCells
  40. Kostulas N, Pelidou SH, Kivisäkk P, Kostulas V, Link H. Increased IL-1beta, IL-8, and IL-17 mRNA expression in blood mononuclear cells observed in a prospective ischemic stroke study. Stroke. 1999 Oct; 30(10):2174-9. PMID: 10512924.
    Citations: 42     Fields:    Translation:HumansCellsCTClinical Trials
  41. Pashenkov M, Mustafa M, Kivisäkk P, Link H. Levels of interleukin-15-expressing blood mononuclear cells are elevated in multiple sclerosis. Scand J Immunol. 1999 Sep; 50(3):302-8. PMID: 10447940.
    Citations: 4     Fields:    Translation:HumansCells
  42. Kivisäkk P, Stawiarz L, Matusevicius D, Fredrikson S, Söderström M, Hindmarsh T, Link H. High numbers of perforin mRNA expressing CSF cells in multiple sclerosis patients with gadolinium-enhancing brain MRI lesions. Acta Neurol Scand. 1999 Jul; 100(1):18-24. PMID: 10416508.
    Citations: 1     Fields:    Translation:HumansCells
  43. Pelidou SH, Kostulas N, Matusevicius D, Kivisäkk P, Kostulas V, Link H. High levels of IL-10 secreting cells are present in blood in cerebrovascular diseases. Eur J Neurol. 1999 Jul; 6(4):437-42. PMID: 10362896.
    Citations: 19     Fields:    Translation:HumansCellsCTClinical Trials
  44. Ozenci V, Rinaldi L, Teleshova N, Matusevicius D, Kivisäkk P, Kouwenhoven M, Link H. Metalloproteinases and their tissue inhibitors in multiple sclerosis. J Autoimmun. 1999 Jun; 12(4):297-303. PMID: 10330301.
    Citations: 10     Fields:    Translation:HumansCells
  45. Ozenci V, Kouwenhoven M, Huang YM, Xiao B, Kivisäkk P, Fredrikson S, Link H. Multiple sclerosis: levels of interleukin-10-secreting blood mononuclear cells are low in untreated patients but augmented during interferon-beta-1b treatment. Scand J Immunol. 1999 May; 49(5):554-61. PMID: 10320650.
    Citations: 16     Fields:    Translation:HumansCells
  46. Matusevicius D, Kivisäkk P, He B, Kostulas N, Ozenci V, Fredrikson S, Link H. Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis. Mult Scler. 1999 Apr; 5(2):101-4. PMID: 10335518.
    Citations: 215     Fields:    Translation:HumansCells
  47. Kivisäkk P. Cytokines and cerebrospinal fluid: methodology, findings and clinical relevance in multiple sclerosis. Fredrikson S and Link H (eds): Advances in multiple sclerosis. Clinical research and therapy. 1999; 33-42.
  48. Kivisäkk P, Teleshova N, Ozenci V, Huang Y, Matusevicius D, Fredrikson S, Söderström M, Link H. No evidence for elevated numbers of mononuclear cells expressing MCP-1 and RANTES mRNA in blood and CSF in multiple sclerosis. J Neuroimmunol. 1998 Nov 02; 91(1-2):108-12. PMID: 9846826.
    Citations: 2     Fields:    Translation:HumansCells
  49. Xiao BG, Mousa A, Kivisäkk P, Seiger A, Bakhiet M, Link H. Induction of beta-family chemokines mRNA in human embryonic astrocytes by inflammatory cytokines and measles virus protein. J Neurocytol. 1998 Aug; 27(8):575-80. PMID: 10405024.
    Citations: 4     Fields:    Translation:HumansCells
  50. Matusevicius D, Kivisäkk P, Navikas V, Söderström M, Fredrikson S, Link H. Interleukin-12 and perforin mRNA expression is augmented in blood mononuclear cells in multiple sclerosis. Scand J Immunol. 1998 Jun; 47(6):582-90. PMID: 9652827.
    Citations: 3     Fields:    Translation:HumansCells
  51. Matusevicius D, Kivisakk P, Navikas V, Tian W, Soderstrom M, Fredrikson S, Link H. Influence of IFN-beta1b (Betaferon) on cytokine mRNA profiles in blood mononuclear cells and plasma levels of soluble VCAM-1 in multiple sclerosis. Eur J Neurol. 1998 May; 5(3):265-275. PMID: 10210841.
    Citations: 2     Fields:    
  52. Kivisäkk P, Lundahl J, von Heigl Z, Fredrikson S. No evidence for increased frequency of autoantibodies during interferon-beta1b treatment of multiple sclerosis. Acta Neurol Scand. 1998 May; 97(5):320-3. PMID: 9613562.
    Citations: 3     Fields:    Translation:Humans
  53. Elkarim RA, Mustafa M, Kivisäkk P, Link H, Bakhiet M. Cytokine autoantibodies in multiple sclerosis, aseptic meningitis and stroke. Eur J Clin Invest. 1998 Apr; 28(4):295-9. PMID: 9615907.
    Citations: 9     Fields:    Translation:Humans
  54. Kostulas N, Kivisäkk P, Huang Y, Matusevicius D, Kostulas V, Link H. Ischemic stroke is associated with a systemic increase of blood mononuclear cells expressing interleukin-8 mRNA. Stroke. 1998 Feb; 29(2):462-6. PMID: 9472890.
    Citations: 18     Fields:    Translation:HumansCells
  55. Kivisäkk P, Tian W, Matusevicius D, Link H, Söderström M. Optic neuritis and cytokines: no relation to MRI abnormalities and oligoclonal bands. Neurology. 1998 Jan; 50(1):217-23. PMID: 9443483.
    Citations:    Fields:    Translation:HumansCells
  56. Kivisäkk P. Studies on the cytokine network in multiple sclerosis. 1998.
  57. Kivisäkk P, Matusevicius D, He B, Söderström M, Fredrikson S, Link H. IL-15 mRNA expression is up-regulated in blood and cerebrospinal fluid mononuclear cells in multiple sclerosis (MS). Clin Exp Immunol. 1998 Jan; 111(1):193-7. PMID: 9472681.
    Citations: 14     Fields:    Translation:HumansCells
  58. Kivisäkk P, Alm GV, Tian WZ, Matusevicius D, Fredrikson S, Link H. Neutralising and binding anti-interferon-beta-I b (IFN-beta-I b) antibodies during IFN-beta-I b treatment of multiple sclerosis. Mult Scler. 1997 Jun; 3(3):184-90. PMID: 9310964.
    Citations: 3     Fields:    Translation:HumansCells
  59. Matusevicius D, Kivisäkk P, Navikas V, Xiao BG, Söderström M, Olsson T, Pirskanen R, Fredrikson S, Link H. Autoantigen-induced IL-13 mRNA expression is augmented in blood mononuclear cells in myasthenia gravis and multiple sclerosis. Eur J Neurol. 1997; 4:468-475.
  60. Kivisäkk P, Tian WZ, Fredrikson S, Link H, Söderström M. Multiple sclerosis: Myelin basic protein induced mRNA expression of proinflammatory cytokines in mononuclear cells is suppressed by interferon-b1b in vitro. Eur J Neurol. 1997; 4:460-467.
  61. Navikas V, Matusevicius D, Söderström M, Fredrikson S, Kivisäkk P, Ljungdahl A, Höjeberg B, Link H. Increased interleukin-6 mRNA expression in blood and cerebrospinal fluid mononuclear cells in multiple sclerosis. J Neuroimmunol. 1996 Jan; 64(1):63-9. PMID: 8598391.
    Citations: 8     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.