Harvard Catalyst Profiles

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Robert J. Mallis, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Duke-Cohan JS, Akitsu A, Mallis RJ, Messier CM, Lizotte PH, Aster JC, Hwang W, Lang MJ, Reinherz EL. Pre-T cell receptor self-MHC sampling restricts thymocyte dedifferentiation. Nature. 2023 01; 613(7944):565-574. PMID: 36410718; PMCID: PMC9851994.
    Citations:    Fields:    Translation:AnimalsCells
  2. Stephens HM, Brazin KN, Mallis RJ, Feng Y, Banik D, Reinherz EL, Lang MJ. Measuring aß T-Cell Receptor-Mediated Mechanosensing Using Optical Tweezers Combined with Fluorescence Imaging. Methods Mol Biol. 2022; 2478:727-753. PMID: 36063340.
    Citations:    Fields:    Translation:Cells
  3. Mallis RJ, Duke-Cohan JS, Das DK, Akitsu A, Luoma AM, Banik D, Stephens HM, Tetteh PW, Castro CD, Krahnke S, Hussey RE, Lawney B, Brazin KN, Reche PA, Hwang W, Adams EJ, Lang MJ, Reinherz EL. Molecular design of the ?dT cell receptor ectodomain encodes biologically fit ligand recognition in the absence of mechanosensing. Proc Natl Acad Sci U S A. 2021 06 29; 118(26). PMID: 34172580.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  4. Mizsei R, Li X, Chen WN, Szabo M, Wang JH, Wagner G, Reinherz EL, Mallis RJ. A general chemical crosslinking strategy for structural analyses of weakly interacting proteins applied to preTCR-pMHC complexes. J Biol Chem. 2021 Jan-Jun; 296:100255. PMID: 33837736; PMCID: PMC7948749.
    Citations: 1     Fields:    Translation:HumansCells
  5. Mizsei R, Li X, Chen WN, Szabo M, Wang JH, Wagner G, Reinherz EL, Mallis RJ. A general chemical crosslinking strategy for structural analyses of weakly interacting proteins applied to preTCR-pMHC complexes. J Biol Chem. 2021 Jan 04. PMID: 33397788.
    Citations:    Fields:    
  6. Li X, Mizsei R, Tan K, Mallis RJ, Duke-Cohan JS, Akitsu A, Tetteh PW, Dubey A, Hwang W, Wagner G, Lang MJ, Arthanari H, Wang JH, Reinherz EL. Pre-T cell receptors topologically sample self-ligands during thymocyte ß-selection. Science. 2021 01 08; 371(6525):181-185. PMID: 33335016; PMCID: PMC8011828.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  7. Hwang W, Mallis RJ, Lang MJ, Reinherz EL. The aßTCR mechanosensor exploits dynamic ectodomain allostery to optimize its ligand recognition site. Proc Natl Acad Sci U S A. 2020 09 01; 117(35):21336-21345. PMID: 32796106.
    Citations: 19     Fields:    Translation:HumansCells
  8. Mallis RJ, Brazin KN, Duke-Cohan JS, Hwang W, Wang JH, Wagner G, Arthanari H, Lang MJ, Reinherz EL. NMR: an essential structural tool for integrative studies of T cell development, pMHC ligand recognition and TCR mechanobiology. J Biomol NMR. 2019 Jul; 73(6-7):319-332. PMID: 30815789.
    Citations: 8     Fields:    Translation:HumansCells
  9. Brazin KN, Mallis RJ, Boeszoermenyi A, Feng Y, Yoshizawa A, Reche PA, Kaur P, Bi K, Hussey RE, Duke-Cohan JS, Song L, Wagner G, Arthanari H, Lang MJ, Reinherz EL. The T Cell Antigen Receptor a Transmembrane Domain Coordinates Triggering through Regulation of Bilayer Immersion and CD3 Subunit Associations. Immunity. 2018 11 20; 49(5):829-841.e6. PMID: 30389415.
    Citations: 26     Fields:    Translation:Cells
  10. Mallis RJ, Arthanari H, Lang MJ, Reinherz EL, Wagner G. NMR-directed design of pre-TCRß and pMHC molecules implies a distinct geometry for pre-TCR relative to aßTCR recognition of pMHC. J Biol Chem. 2018 01 19; 293(3):754-766. PMID: 29101227.
    Citations: 4     Fields:    Translation:Cells
  11. Feng Y, Brazin KN, Kobayashi E, Mallis RJ, Reinherz EL, Lang MJ. Mechanosensing drives acuity of aß T-cell recognition. Proc Natl Acad Sci U S A. 2017 09 26; 114(39):E8204-E8213. PMID: 28811364; PMCID: PMC5625899.
    Citations: 74     Fields:    Translation:AnimalsCells
  12. Das DK, Mallis RJ, Duke-Cohan JS, Hussey RE, Tetteh PW, Hilton M, Wagner G, Lang MJ, Reinherz EL. Pre-T Cell Receptors (Pre-TCRs) Leverage Vß Complementarity Determining Regions (CDRs) and Hydrophobic Patch in Mechanosensing Thymic Self-ligands. J Biol Chem. 2016 Dec 02; 291(49):25292-25305. PMID: 27707880.
    Citations: 26     Fields:    Translation:AnimalsCells
  13. Brazin KN, Mallis RJ, Das DK, Feng Y, Hwang W, Wang JH, Wagner G, Lang MJ, Reinherz EL. Structural Features of the aßTCR Mechanotransduction Apparatus That Promote pMHC Discrimination. Front Immunol. 2015; 6:441. PMID: 26388869.
    Citations: 37     Fields:    
  14. Mallis RJ, Reinherz EL, Wagner G, Arthanari H. Backbone resonance assignment of N15, N30 and D10 T cell receptor ß subunits. Biomol NMR Assign. 2016 Apr; 10(1):35-9. PMID: 26275917.
    Citations: 3     Fields:    Translation:Cells
  15. Mallis RJ, Bai K, Arthanari H, Hussey RE, Handley M, Li Z, Chingozha L, Duke-Cohan JS, Lu H, Wang JH, Zhu C, Wagner G, Reinherz EL. Pre-TCR ligand binding impacts thymocyte development before aßTCR expression. Proc Natl Acad Sci U S A. 2015 Jul 07; 112(27):8373-8. PMID: 26056289; PMCID: PMC4500245.
    Citations: 34     Fields:    Translation:AnimalsCells
  16. Das DK, Feng Y, Mallis RJ, Li X, Keskin DB, Hussey RE, Brady SK, Wang JH, Wagner G, Reinherz EL, Lang MJ. Force-dependent transition in the T-cell receptor ß-subunit allosterically regulates peptide discrimination and pMHC bond lifetime. Proc Natl Acad Sci U S A. 2015 Feb 03; 112(5):1517-22. PMID: 25605925; PMCID: PMC4321250.
    Citations: 123     Fields:    Translation:Cells
  17. Brazin KN, Mallis RJ, Li C, Keskin DB, Arthanari H, Gao Y, Wu SL, Karger BL, Wagner G, Reinherz EL. Constitutively oxidized CXXC motifs within the CD3 heterodimeric ectodomains of the T cell receptor complex enforce the conformation of juxtaposed segments. J Biol Chem. 2015 Jan 2; 290(1):239. PMID: 25556239.
  18. Brazin KN, Mallis RJ, Li C, Keskin DB, Arthanari H, Gao Y, Wu SL, Karger BL, Wagner G, Reinherz EL. Constitutively oxidized CXXC motifs within the CD3 heterodimeric ectodomains of the T cell receptor complex enforce the conformation of juxtaposed segments. J Biol Chem. 2014 Jul 04; 289(27):18880-92. PMID: 24849600.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  19. Kim ST, Shin Y, Brazin K, Mallis RJ, Sun ZY, Wagner G, Lang MJ, Reinherz EL. TCR Mechanobiology: Torques and Tunable Structures Linked to Early T Cell Signaling. Front Immunol. 2012; 3:76. PMID: 22566957.
    Citations: 41     Fields:    
  20. Zhou B, Chen Q, Mallis RJ, Zhang H, Liu JH, Reinherz EL, Wang JH. A conserved hydrophobic patch on Vß domains revealed by TCRß chain crystal structures: Implications for pre-TCR dimerization. Front Immunol. 2011; 2:5. PMID: 22566796.
    Citations: 14     Fields:    
  21. Wang JH, Mallis RJ, Reinherz EL. Immunodominant-peptide recognition: beta testing TCRalphabeta. Immunity. 2008 Feb; 28(2):139-41. PMID: 18275824.
    Citations: 3     Fields:    Translation:HumansCells
  22. Zhong W, Dixit SB, Mallis RJ, Arthanari H, Lugovskoy AA, Beveridge DL, Wagner G, Reinherz EL. CTL recognition of a protective immunodominant influenza A virus nucleoprotein epitope utilizes a highly restricted Vbeta but diverse Valpha repertoire: functional and structural implications. J Mol Biol. 2007 Sep 14; 372(2):535-48. PMID: 17658550.
    Citations: 14     Fields:    Translation:AnimalsCells
  23. Mallis RJ, Brazin KN, Fulton DB, Andreotti AH. Structural characterization of a proline-driven conformational switch within the Itk SH2 domain. Nat Struct Biol. 2002 Dec; 9(12):900-5. PMID: 12402030.
    Citations: 43     Fields:    Translation:AnimalsCells
  24. Mallis RJ, Hamann MJ, Zhao W, Zhang T, Hendrich S, Thomas JA. Irreversible thiol oxidation in carbonic anhydrase III: protection by S-glutathiolation and detection in aging rats. Biol Chem. 2002 Mar-Apr; 383(3-4):649-62. PMID: 12033454.
    Citations: 20     Fields:    Translation:AnimalsCells
  25. Brazin KN, Mallis RJ, Fulton DB, Andreotti AH. Regulation of the tyrosine kinase Itk by the peptidyl-prolyl isomerase cyclophilin A. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):1899-904. PMID: 11830645; PMCID: PMC122291.
    Citations: 93     Fields:    Translation:HumansCells
  26. Mallis RJ, Brazin K, Jez JM, Wilson EK, Dieckmann GR, Robic S, Harrahy J. Proteins: the complete works. Trends Biochem Sci. 2001 Nov; 26(11):642-3. PMID: 11701309.
    Citations:    Fields:    Translation:HumansAnimalsCells
  27. Thomas JA, Mallis RJ. Aging and oxidation of reactive protein sulfhydryls. Exp Gerontol. 2001 Sep; 36(9):1519-26. PMID: 11525874.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  28. Mallis RJ, Buss JE, Thomas JA. Oxidative modification of H-ras: S-thiolation and S-nitrosylation of reactive cysteines. Biochem J. 2001 Apr 01; 355(Pt 1):145-53. PMID: 11256959; PMCID: PMC1221722.
    Citations: 43     Fields:    Translation:AnimalsCells
  29. Mallis RJ, Thomas JA. Effect of S-nitrosothiols on cellular glutathione and reactive protein sulfhydryls. Arch Biochem Biophys. 2000 Nov 01; 383(1):60-9. PMID: 11097177.
    Citations: 10     Fields:    Translation:AnimalsCells
  30. Mallis RJ, Poland BW, Chatterjee TK, Fisher RA, Darmawan S, Honzatko RB, Thomas JA. Crystal structure of S-glutathiolated carbonic anhydrase III. FEBS Lett. 2000 Oct 06; 482(3):237-41. PMID: 11024467.
    Citations: 21     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.