Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Bruce Harold Horwitz, M.D., Ph.D.

Title
Institution
Department
Address
Phone
Fax

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI052267 (HORWITZ, BRUCE H.) Jul 1, 2002 - Jun 30, 2012
    NIH/NIAID
    Inhibition of Microflora-Induced Colitis by NF-kB
    Role: Principal Investigator
  2. P30AR042689 (KUPPER, THOMAS S.) Apr 1, 1994 - Oct 13, 2011
    NIH/NIAMS
    Harvard Skin Disease Research Center
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ryzhakov G, West NR, Franchini F, Clare S, Ilott NE, Sansom SN, Bullers SJ, Pearson C, Costain A, Vaughan-Jackson A, Goettel JA, Ermann J, Horwitz BH, Buti L, Lu X, Mukhopadhyay S, Snapper SB, Powrie F. Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis. Nat Commun. 2018 09 18; 9(1):3797. PMID: 30228258.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Biswas A, Shouval DS, Griffith A, Goettel JA, Field M, Kang YH, Konnikova L, Janssen E, Redhu NS, Thrasher AJ, Chatila T, Kuchroo VK, Geha RS, Notarangelo LD, Pai SY, Horwitz BH, Snapper SB. WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis. Nat Commun. 2018 05 03; 9(1):1779. PMID: 29725003.
    Citations:    Fields:    Translation:HumansAnimalsCells
  3. Redhu NS, Bakthavatchalu V, Conaway EA, Shouval DS, Tsou A, Goettel JA, Biswas A, Wang C, Field M, Muller W, Bleich A, Li N, Gerber GK, Bry L, Fox JG, Snapper SB, Horwitz BH. Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor. Elife. 2017 07 05; 6. PMID: 28678006.
    Citations: 1     Fields:    Translation:AnimalsCells
  4. Conaway EA, de Oliveira DC, McInnis CM, Snapper SB, Horwitz BH. Inhibition of Inflammatory Gene Transcription by IL-10 Is Associated with Rapid Suppression of Lipopolysaccharide-Induced Enhancer Activation. J Immunol. 2017 04 01; 198(7):2906-2915. PMID: 28213503.
    Citations: 2     Fields:    Translation:AnimalsCells
  5. Wang C, Gong G, Sheh A, Muthupalani S, Bryant EM, Puglisi DA, Holcombe H, Conaway EA, Parry NAP, Bakthavatchalu V, Short SP, Williams CS, Wogan GN, Tannenbaum SR, Fox JG, Horwitz BH. Interleukin-22 drives nitric oxide-dependent DNA damage and dysplasia in a murine model of colitis-associated cancer. Mucosal Immunol. 2017 11; 10(6):1504-1517. PMID: 28198364.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  6. Shouval DS, Biswas A, Kang YH, Griffith AE, Konnikova L, Mascanfroni ID, Redhu NS, Frei SM, Field M, Doty AL, Goldsmith JD, Bhan AK, Loizides A, Weiss B, Yerushalmi B, Yanagi T, Lui X, Quintana FJ, Muise AM, Klein C, Horwitz BH, Glover SC, Bousvaros A, Snapper SB. Interleukin 1ß Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency. Gastroenterology. 2016 12; 151(6):1100-1104. PMID: 27693323.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  7. Redhu N, Shouval D, Bakthavatchalu V, Wang C, Conaway E, Goettel J, Mack M, Bleich A, Bry L, Fox J, Snapper S, Horwitz B. O-005 YI Microbiota Drives Inflammation by Altering Intestinal Lamina Propria Macrophage Phenotype in a Novel IL10R-Deficient Model of Very Early Onset IBD. Inflamm Bowel Dis. 2016 Mar; 22 Suppl 1:S2-3. PMID: 26849723.
    Citations:    
  8. Goettel JA, Biswas S, Lexmond WS, Yeste A, Passerini L, Patel B, Yang S, Sun J, Ouahed J, Shouval DS, McCann KJ, Horwitz BH, Mathis D, Milford EL, Notarangelo LD, Roncarolo MG, Fiebiger E, Marasco WA, Bacchetta R, Quintana FJ, Pai SY, Klein C, Muise AM, Snapper SB. Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3. Blood. 2015 Jun 18; 125(25):3886-95. PMID: 25833964.
    Citations: 9     Fields:    Translation:HumansAnimals
  9. Shouval DS, Biswas A, Goettel JA, McCann K, Conaway E, Redhu NS, Mascanfroni ID, Al Adham Z, Lavoie S, Ibourk M, Nguyen DD, Samsom JN, Escher JC, Somech R, Weiss B, Beier R, Conklin LS, Ebens CL, Santos FG, Ferreira AR, Sherlock M, Bhan AK, Müller W, Mora JR, Quintana FJ, Klein C, Muise AM, Horwitz BH, Snapper SB. Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function. Immunity. 2014 May 15; 40(5):706-19. PMID: 24792912.
    Citations: 94     Fields:    Translation:HumansAnimalsCells
  10. Shouval DS, Ouahed J, Biswas A, Goettel JA, Horwitz BH, Klein C, Muise AM, Snapper SB. Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans. Adv Immunol. 2014; 122:177-210. PMID: 24507158.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  11. Poutahidis T, Cappelle K, Levkovich T, Lee CW, Doulberis M, Ge Z, Fox JG, Horwitz BH, Erdman SE. Pathogenic intestinal bacteria enhance prostate cancer development via systemic activation of immune cells in mice. PLoS One. 2013; 8(8):e73933. PMID: 23991210.
    Citations: 16     Fields:    Translation:Animals
  12. Venkatesh D, Ernandez T, Rosetti F, Batal I, Cullere X, Luscinskas FW, Zhang Y, Stavrakis G, García-Cardeña G, Horwitz BH, Mayadas TN. Endothelial TNF receptor 2 induces IRF1 transcription factor-dependent interferon-ß autocrine signaling to promote monocyte recruitment. Immunity. 2013 May 23; 38(5):1025-37. PMID: 23623383.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  13. Nguyen DD, Wurbel MA, Goettel JA, Eston MA, Ahmed OS, Marin R, Boden EK, Villablanca EJ, Paidassi H, Ahuja V, Reinecker HC, Fiebiger E, Lacy-Hulbert A, Horwitz BH, Mora JR, Snapper SB. Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice. Gastroenterology. 2012 Sep; 143(3):719-729.e2. PMID: 22710191.
    Citations: 14     Fields:    Translation:AnimalsCells
  14. Zhao X, Ross EJ, Wang Y, Horwitz BH. Nfkb1 inhibits LPS-induced IFN-ß and IL-12 p40 production in macrophages by distinct mechanisms. PLoS One. 2012; 7(3):e32811. PMID: 22427889.
    Citations: 5     Fields:    Translation:AnimalsCells
  15. Yang HT, Wang Y, Zhao X, Demissie E, Papoutsopoulou S, Mambole A, O'Garra A, Tomczak MF, Erdman SE, Fox JG, Ley SC, Horwitz BH. NF-?B1 inhibits TLR-induced IFN-ß production in macrophages through TPL-2-dependent ERK activation. J Immunol. 2011 Feb 15; 186(4):1989-96. PMID: 21217011.
    Citations: 11     Fields:    Translation:AnimalsCells
  16. Fox JG, Ge Z, Whary MT, Erdman SE, Horwitz BH. Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancer. Mucosal Immunol. 2011 Jan; 4(1):22-30. PMID: 20944559.
    Citations: 67     Fields:    Translation:AnimalsCells
  17. Erdman SE, Rao VP, Olipitz W, Taylor CL, Jackson EA, Levkovich T, Lee CW, Horwitz BH, Fox JG, Ge Z, Poutahidis T. Unifying roles for regulatory T cells and inflammation in cancer. Int J Cancer. 2010 Apr 01; 126(7):1651-65. PMID: 19795459.
    Citations: 33     Fields:    Translation:AnimalsCells
  18. Allister L, Bachur R, Glickman J, Horwitz B. Serum markers in acute appendicitis. J Surg Res. 2011 Jun 01; 168(1):70-5. PMID: 20097375.
    Citations: 4     Fields:    Translation:Humans
  19. Kentsis A, Lin YY, Kurek K, Calicchio M, Wang YY, Monigatti F, Campagne F, Lee R, Horwitz B, Steen H, Bachur R. Discovery and validation of urine markers of acute pediatric appendicitis using high-accuracy mass spectrometry. Ann Emerg Med. 2010 Jan; 55(1):62-70.e4. PMID: 19556024.
    Citations: 29     Fields:    Translation:Humans
  20. Watanabe K, Rao VP, Poutahidis T, Rickman BH, Ohtani M, Xu S, Rogers AB, Ge Z, Horwitz BH, Fujioka T, Erdman SE, Fox JG. Cytotoxic-T-lymphocyte-associated antigen 4 blockade abrogates protection by regulatory T cells in a mouse model of microbially induced innate immune-driven colitis. Infect Immun. 2008 Dec; 76(12):5834-42. PMID: 18824539.
    Citations: 8     Fields:    Translation:AnimalsCells
  21. Murphy CG, Glickman JN, Tomczak K, Wang YY, Beggs AH, Shannon MW, Horwitz BH. Acute appendicitis is characterized by a uniform and highly selective pattern of inflammatory gene expression. Mucosal Immunol. 2008 Jul; 1(4):297-308. PMID: 19079191.
    Citations: 9     Fields:    Translation:HumansCells
  22. Wang Y, Rickman BH, Poutahidis T, Schlieper K, Jackson EA, Erdman SE, Fox JG, Horwitz BH. c-Rel is essential for the development of innate and T cell-induced colitis. J Immunol. 2008 Jun 15; 180(12):8118-25. PMID: 18523276.
    Citations: 17     Fields:    Translation:AnimalsCells
  23. Gadjeva M, Wang Y, Horwitz BH. NF-kappaB p50 and p65 subunits control intestinal homeostasis. Eur J Immunol. 2007 Sep; 37(9):2509-17. PMID: 17705134.
    Citations: 7     Fields:    Translation:Animals
  24. Poutahidis T, Haigis KM, Rao VP, Nambiar PR, Taylor CL, Ge Z, Watanabe K, Davidson A, Horwitz BH, Fox JG, Erdman SE. Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma. Carcinogenesis. 2007 Dec; 28(12):2614-23. PMID: 17724375.
    Citations: 34     Fields:    Translation:AnimalsCells
  25. Horwitz BH. The straw that stirs the drink: insight into the pathogenesis of inflammatory bowel disease revealed through the study of microflora-induced inflammation in genetically modified mice. Inflamm Bowel Dis. 2007 Apr; 13(4):490-500. PMID: 17243141.
    Citations: 7     Fields:    Translation:AnimalsCells
  26. Tomczak MF, Erdman SE, Davidson A, Wang YY, Nambiar PR, Rogers AB, Rickman B, Luchetti D, Fox JG, Horwitz BH. Inhibition of Helicobacter hepaticus-induced colitis by IL-10 requires the p50/p105 subunit of NF-kappa B. J Immunol. 2006 Nov 15; 177(10):7332-9. PMID: 17082652.
    Citations: 17     Fields:    Translation:AnimalsCells
  27. Rao VP, Poutahidis T, Ge Z, Nambiar PR, Boussahmain C, Wang YY, Horwitz BH, Fox JG, Erdman SE. Innate immune inflammatory response against enteric bacteria Helicobacter hepaticus induces mammary adenocarcinoma in mice. Cancer Res. 2006 Aug 01; 66(15):7395-400. PMID: 16885333.
    Citations: 65     Fields:    Translation:AnimalsCells
  28. Tomczak MF, Gadjeva M, Wang YY, Brown K, Maroulakou I, Tsichlis PN, Erdman SE, Fox JG, Horwitz BH. Defective activation of ERK in macrophages lacking the p50/p105 subunit of NF-kappaB is responsible for elevated expression of IL-12 p40 observed after challenge with Helicobacter hepaticus. J Immunol. 2006 Jan 15; 176(2):1244-51. PMID: 16394015.
    Citations: 16     Fields:    Translation:AnimalsCells
  29. Rao VP, Poutahidis T, Ge Z, Nambiar PR, Horwitz BH, Fox JG, Erdman SE. Proinflammatory CD4+ CD45RB(hi) lymphocytes promote mammary and intestinal carcinogenesis in Apc(Min/+) mice. Cancer Res. 2006 Jan 01; 66(1):57-61. PMID: 16397216.
    Citations: 37     Fields:    Translation:AnimalsCells
  30. Horwitz B. NF-kappa B, an inhibitor of microflora-induced colitis. J Pediatr Gastroenterol Nutr. 2005 Apr; 40 Suppl 1:S22-3. PMID: 15805835.
    Citations: 1     Fields:    Translation:HumansAnimals
  31. Gadjeva M, Tomczak MF, Zhang M, Wang YY, Dull K, Rogers AB, Erdman SE, Fox JG, Carroll M, Horwitz BH. A role for NF-kappa B subunits p50 and p65 in the inhibition of lipopolysaccharide-induced shock. J Immunol. 2004 Nov 01; 173(9):5786-93. PMID: 15494531.
    Citations: 29     Fields:    Translation:AnimalsCells
  32. Dedeoglu F, Horwitz B, Chaudhuri J, Alt FW, Geha RS. Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB. Int Immunol. 2004 Mar; 16(3):395-404. PMID: 14978013.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  33. Fox JG, Rogers AB, Whary MT, Ge Z, Taylor NS, Xu S, Horwitz BH, Erdman SE. Gastroenteritis in NF-kappaB-deficient mice is produced with wild-type Camplyobacter jejuni but not with C. jejuni lacking cytolethal distending toxin despite persistent colonization with both strains. Infect Immun. 2004 Feb; 72(2):1116-25. PMID: 14742559.
    Citations: 61     Fields:    Translation:AnimalsCells
  34. Liang SC, Latchman YE, Buhlmann JE, Tomczak MF, Horwitz BH, Freeman GJ, Sharpe AH. Regulation of PD-1, PD-L1, and PD-L2 expression during normal and autoimmune responses. Eur J Immunol. 2003 Oct; 33(10):2706-16. PMID: 14515254.
    Citations: 154     Fields:    Translation:AnimalsCells
  35. Erdman SE, Rao VP, Poutahidis T, Ihrig MM, Ge Z, Feng Y, Tomczak M, Rogers AB, Horwitz BH, Fox JG. CD4(+)CD25(+) regulatory lymphocytes require interleukin 10 to interrupt colon carcinogenesis in mice. Cancer Res. 2003 Sep 15; 63(18):6042-50. PMID: 14522933.
    Citations: 90     Fields:    Translation:AnimalsCells
  36. Tomczak MF, Erdman SE, Poutahidis T, Rogers AB, Holcombe H, Plank B, Fox JG, Horwitz BH. NF-kappa B is required within the innate immune system to inhibit microflora-induced colitis and expression of IL-12 p40. J Immunol. 2003 Aug 01; 171(3):1484-92. PMID: 12874241.
    Citations: 16     Fields:    Translation:AnimalsCells
  37. Erdman SE, Poutahidis T, Tomczak M, Rogers AB, Cormier K, Plank B, Horwitz BH, Fox JG. CD4+ CD25+ regulatory T lymphocytes inhibit microbially induced colon cancer in Rag2-deficient mice. Am J Pathol. 2003 Feb; 162(2):691-702. PMID: 12547727.
    Citations: 106     Fields:    Translation:AnimalsCells
  38. Alcamo E, Mizgerd JP, Horwitz BH, Bronson R, Beg AA, Scott M, Doerschuk CM, Hynes RO, Baltimore D. Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-kappa B in leukocyte recruitment. J Immunol. 2001 Aug 01; 167(3):1592-600. PMID: 11466381.
    Citations: 83     Fields:    Translation:Animals
  39. Horwitz BH, Mizgerd JP, Scott ML, Doerschuk CM. Mechanisms of granulocytosis in the absence of CD18. Blood. 2001 Mar 15; 97(6):1578-83. PMID: 11238094.
    Citations: 14     Fields:    Translation:AnimalsCells
  40. Erdman S, Fox JG, Dangler CA, Feldman D, Horwitz BH. Typhlocolitis in NF-kappa B-deficient mice. J Immunol. 2001 Feb 01; 166(3):1443-7. PMID: 11160181.
    Citations: 43     Fields:    Translation:Animals
  41. Cariappa A, Liou HC, Horwitz BH, Pillai S. Nuclear factor kappa B is required for the development of marginal zone B lymphocytes. J Exp Med. 2000 Oct 16; 192(8):1175-82. PMID: 11034607.
    Citations: 45     Fields:    Translation:AnimalsCells
  42. Mizgerd JP, Horwitz BH, Quillen HC, Scott ML, Doerschuk CM. Effects of CD18 deficiency on the emigration of murine neutrophils during pneumonia. J Immunol. 1999 Jul 15; 163(2):995-9. PMID: 10395697.
    Citations: 20     Fields:    Translation:AnimalsCells
  43. Horwitz BH, Zelazowski P, Shen Y, Wolcott KM, Scott ML, Baltimore D, Snapper CM. The p65 subunit of NF-kappa B is redundant with p50 during B cell proliferative responses, and is required for germline CH transcription and class switching to IgG3. J Immunol. 1999 Feb 15; 162(4):1941-6. PMID: 9973462.
    Citations: 14     Fields:    Translation:AnimalsCells
  44. Horwitz BH, Scott ML, Cherry SR, Bronson RT, Baltimore D. Failure of lymphopoiesis after adoptive transfer of NF-kappaB-deficient fetal liver cells. Immunity. 1997 Jun; 6(6):765-72. PMID: 9208848.
    Citations: 44     Fields:    Translation:AnimalsCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Horwitz's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (266)
Explore
_
Co-Authors (39)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Physical Neighbors
_
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.