Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Matthew L. Warman, M.D.

Other Positions

Generation of Anti-Treatment Antibodies in a Mouse Model of Osteogenesis Imperfectacta
Summer, 05/29/12 - 09/04/12
Investigating Atypical Synchondrosis Closure in the Cranial Base of DBA/2J Mice
Summer, 06/20/11 - 08/12/11

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AR077292 (WARMAN, MATTHEW L) Jun 2, 2021 - May 31, 2023
    Neurobehavioral phenotypes of mouse models of Osteogenesis Imperfecta
    Role: Principal Investigator
  2. R21AR076105 (CRAFT, APRIL MARIE) Jul 9, 2019 - Jun 30, 2021
    Progressive Pseudorheumatoid Arthropathy of Childhood
    Role: Co-Principal Investigator
  3. R21AR067388 (WARMAN, MATTHEW L) Apr 1, 2015 - Mar 31, 2019
    The Efficacy of combination therapy in Osteogenesis Imperfecta
    Role: Principal Investigator
  4. R13AR066509 (WARMAN, MATTHEW L) Jun 1, 2014 - May 31, 2015
    Mechanistic and Therapeutic Insights into Skeletal Biology Learned from the Study
    Role: Principal Investigator
  5. R01AR064231 (WARMAN, MATTHEW L) Apr 3, 2014 - Mar 31, 2020
    Non-heritable genetic diseases of the skeletal system: Pathogenesis and Treatment
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Smits PJ, Sudduth CL, Konczyk DJ, Cheng YS, Vivero MP, Kozakewich HPW, Warman ML, Greene AK. Endothelial cell expression of mutant Map2k1 causes vascular malformations in mice. Angiogenesis. 2022 Aug 16. PMID: 35972708.
    Citations:    Fields:    
  2. Resendes C, Horan DJ, Robling AG, Gao B, Milne GL, Warman ML. Transiently increased serotonin has modest or no effects on bone mass accrual in growing female C57BL6/J or growing male and female Lrp5A214V mice. Bone. 2022 05; 158:116307. PMID: 34973493.
    Citations:    Fields:    Translation:Animals
  3. Spatz JM, Ko FC, Ayturk UM, Warman ML, Bouxsein ML. RNAseq and RNA molecular barcoding reveal differential gene expression in cortical bone following hindlimb unloading in female mice. PLoS One. 2021; 16(10):e0250715. PMID: 34637435.
    Citations:    Fields:    Translation:Animals
  4. He Y, Zhang M, Song J, Warman ML. Cell depleted areas do not repopulate after diphtheria toxin-induced killing of mandibular cartilage chondrocytes. Osteoarthritis Cartilage. 2021 10; 29(10):1474-1484. PMID: 34166809.
    Citations:    Fields:    Translation:AnimalsCells
  5. Lim KE, Bullock WA, Horan DJ, Williams BO, Warman ML, Robling AG. Co-deletion of Lrp5 and Lrp6 in the skeleton severely diminishes bone gain from sclerostin antibody administration. Bone. 2021 02; 143:115708. PMID: 33164872; PMCID: PMC7770084.
    Citations: 6     Fields:    Translation:AnimalsCells
  6. Dasgupta K, Lessard S, Hann S, Fowler ME, Robling AG, Warman ML. Sensitive detection of Cre-mediated recombination using droplet digital PCR reveals Tg(BGLAP-Cre) and Tg(DMP1-Cre) are active in multiple non-skeletal tissues. Bone. 2021 01; 142:115674. PMID: 33031974.
    Citations: 1     Fields:    Translation:Animals
  7. Chen D, Liu Y, Shu G, Chen C, Sullivan DA, Kam WR, Hann S, Fowler M, Warman ML. Ocular Manifestations of Chordin-like 1 Knockout Mice. Cornea. 2020 Sep; 39(9):1145-1150. PMID: 32452990; PMCID: PMC7415553.
    Citations:    Fields:    Translation:AnimalsCells
  8. Ayturk UM, Scollan JP, Goz Ayturk D, Suh ES, Vesprey A, Jacobsen CM, Divieti Pajevic P, Warman ML. Single-Cell RNA Sequencing of Calvarial and Long-Bone Endocortical Cells. J Bone Miner Res. 2020 10; 35(10):1981-1991. PMID: 32427356; PMCID: PMC8265023.
    Citations: 11     Fields:    Translation:AnimalsCells
  9. Diegel CR, Hann S, Ayturk UM, Hu JCW, Lim KE, Droscha CJ, Madaj ZB, Foxa GE, Izaguirre I, Robling AG, Warman ML, Williams BO. Independent validation of experimental results requires timely and unrestricted access to animal models and reagents. PLoS Genet. 2020 06; 16(6):e1008940. PMID: 32589665; PMCID: PMC7319330.
    Citations: 3     Fields:    Translation:HumansAnimals
  10. Diegel CR, Hann S, Ayturk UM, Hu JCW, Lim KE, Droscha CJ, Madaj ZB, Foxa GE, Izaguirre I, Transgenics Core VVA, Paracha N, Pidhaynyy B, Dowd TL, Robling AG, Warman ML, Williams BO. An osteocalcin-deficient mouse strain without endocrine abnormalities. PLoS Genet. 2020 05; 16(5):e1008361. PMID: 32463812; PMCID: PMC7255615.
    Citations: 31     Fields:    Translation:Animals
  11. Caetano-Lopes J, Henke K, Urso K, Duryea J, Charles JF, Warman ML, Harris MP. Correction: Unique and non-redundant function of csf1r paralogues in regulation and evolution of post-embryonic development of the zebrafish. Development. 2020 May 18; 147(10). PMID: 32423978; PMCID: PMC7375826.
    Citations: 3     Fields:    
  12. Ayturk UM, Sieker JT, Haslauer CM, Proffen BL, Weissenberger MH, Warman ML, Fleming BC, Murray MM. Proteolysis and cartilage development are activated in the synovium after surgical induction of post traumatic osteoarthritis. PLoS One. 2020; 15(2):e0229449. PMID: 32107493; PMCID: PMC7046188.
    Citations: 3     Fields:    Translation:AnimalsCells
  13. Caetano-Lopes J, Henke K, Urso K, Duryea J, Charles JF, Warman ML, Harris MP. Unique and non-redundant function of csf1r paralogues in regulation and evolution of post-embryonic development of the zebrafish. Development. 2020 01 22; 147(2). PMID: 31932352; PMCID: PMC6983717.
    Citations: 6     Fields:    Translation:AnimalsCells
  14. Goss JA, Huang AY, Smith E, Konczyk DJ, Smits PJ, Sudduth CL, Stapleton C, Patel A, Alexandrescu S, Warman ML, Greene AK. Somatic mutations in intracranial arteriovenous malformations. PLoS One. 2019; 14(12):e0226852. PMID: 31891627.
    Citations: 17     Fields:    Translation:HumansCells
  15. Konczyk DJ, Goss JA, Smits PJ, Huang AY, Al-Ibraheemi A, Sudduth CL, Warman ML, Greene AK. Arteriovenous malformation associated with a HRAS mutation. Hum Genet. 2019 Dec; 138(11-12):1419-1421. PMID: 31637524.
    Citations: 4     Fields:    Translation:Humans
  16. Kaupp S, Horan DJ, Lim KE, Feldman HA, Robling AG, Warman ML, Jacobsen CM. Combination therapy in the Col1a2G610C mouse model of Osteogenesis Imperfecta reveals an additive effect of enhancing LRP5 signaling and inhibiting TGFß signaling on trabecular bone but not on cortical bone. Bone. 2020 02; 131:115084. PMID: 31648079; PMCID: PMC7232829.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  17. Mortier GR, Cohn DH, Cormier-Daire V, Hall C, Krakow D, Mundlos S, Nishimura G, Robertson S, Sangiorgi L, Savarirayan R, Sillence D, Superti-Furga A, Unger S, Warman ML. Nosology and classification of genetic skeletal disorders: 2019 revision. Am J Med Genet A. 2019 12; 179(12):2393-2419. PMID: 31633310.
    Citations: 129     Fields:    Translation:Humans
  18. Moosa S, Yamamoto GL, Garbes L, Keupp K, Beleza-Meireles A, Moreno CA, Valadares ER, de Sousa SB, Maia S, Saraiva J, Honjo RS, Kim CA, Cabral de Menezes H, Lausch E, Lorini PV, Lamounier A, Carniero TCB, Giunta C, Rohrbach M, Janner M, Semler O, Beleggia F, Li Y, Yigit G, Reintjes N, Altmüller J, Nürnberg P, Cavalcanti DP, Zabel B, Warman ML, Bertola DR, Wollnik B, Netzer C. Autosomal-Recessive Mutations in MESD Cause Osteogenesis Imperfecta. Am J Hum Genet. 2019 10 03; 105(4):836-843. PMID: 31564437; PMCID: PMC6817720.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  19. Goss JA, Konczyk DJ, Smits PJ, Kozakewich HPW, Alomari AI, Al-Ibraheemi A, Taghinia AH, Dickie BH, Adams DM, Fishman SJ, Mulliken JB, Warman ML, Greene AK. Intramuscular fast-flow vascular anomaly contains somatic MAP2K1 and KRAS mutations. Angiogenesis. 2019 11; 22(4):547-552. PMID: 31486960.
    Citations: 7     Fields:    Translation:Humans
  20. Bullock WA, Hoggatt AM, Horan DJ, Lewis KJ, Yokota H, Hann S, Warman ML, Sebastian A, Loots GG, Pavalko FM, Robling AG. Expression of a Degradation-Resistant ß-Catenin Mutant in Osteocytes Protects the Skeleton From Mechanodeprivation-Induced Bone Wasting. J Bone Miner Res. 2019 10; 34(10):1964-1975. PMID: 31173667; PMCID: PMC6813861.
    Citations: 6     Fields:    Translation:AnimalsCells
  21. Grigelioniene G, Suzuki HI, Taylan F, Mirzamohammadi F, Borochowitz ZU, Ayturk UM, Tzur S, Horemuzova E, Lindstrand A, Weis MA, Grigelionis G, Hammarsjö A, Marsk E, Nordgren A, Nordenskjöld M, Eyre DR, Warman ML, Nishimura G, Sharp PA, Kobayashi T. Gain-of-function mutation of microRNA-140 in human skeletal dysplasia. Nat Med. 2019 04; 25(4):583-590. PMID: 30804514; PMCID: PMC6622181.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  22. Kang KS, Hong JM, Horan DJ, Lim KE, Bullock WA, Bruzzaniti A, Hann S, Warman ML, Robling AG. Induction of Lrp5 HBM-causing mutations in Cathepsin-K expressing cells alters bone metabolism. Bone. 2019 03; 120:166-175. PMID: 30409757; PMCID: PMC6360125.
    Citations: 3     Fields:    Translation:AnimalsCells
  23. Zuo C, Wang L, Kamalesh RM, Bowen ME, Moore DC, Dooner MS, Reginato AM, Wu Q, Schorl C, Song Y, Warman ML, Neel BG, Ehrlich MG, Yang W. SHP2 regulates skeletal cell fate by modifying SOX9 expression and transcriptional activity. Bone Res. 2018; 6:12. PMID: 29644115.
    Citations: 14     
  24. Michel ME, Konczyk DJ, Yeung KS, Murillo R, Vivero MP, Hall AM, Zurakowski D, Adams D, Gupta A, Huang AY, Chung BHY, Warman ML. Causal somatic mutations in urine DNA from persons with the CLOVES subgroup of the PIK3CA-related overgrowth spectrum. Clin Genet. 2018 05; 93(5):1075-1080. PMID: 29231959; PMCID: PMC5899663.
    Citations: 10     Fields:    Translation:Humans
  25. Bird IM, Kim SH, Schweppe DK, Caetano-Lopes J, Robling AG, Charles JF, Gygi SP, Warman ML, Smits PJ. The skeletal phenotype of achondrogenesis type 1A is caused exclusively by cartilage defects. Development. 2018 01 08; 145(1). PMID: 29180569; PMCID: PMC5825869.
    Citations: 7     Fields:    Translation:AnimalsCells
  26. Wang L, Huang J, Moore DC, Zuo C, Wu Q, Xie L, von der Mark K, Yuan X, Chen D, Warman ML, Ehrlich MG, Yang W. SHP2 Regulates the Osteogenic Fate of Growth Plate Hypertrophic Chondrocytes. Sci Rep. 2017 10 05; 7(1):12699. PMID: 28983104.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  27. Caetano-Lopes J, Lessard SG, Hann S, Espinoza K, Kang KS, Lim KE, Horan DJ, Noonan HR, Hu D, Baron R, Robling AG, Warman ML. Clcn7F318L/+ as a new mouse model of Albers-Schönberg disease. Bone. 2017 Dec; 105:253-261. PMID: 28942122; PMCID: PMC5752150.
    Citations: 5     Fields:    Translation:AnimalsCells
  28. Maccarana M, Svensson RB, Knutsson A, Giannopoulos A, Pelkonen M, Weis M, Eyre D, Warman M, Kalamajski S. Asporin-deficient mice have tougher skin and altered skin glycosaminoglycan content and structure. PLoS One. 2017; 12(8):e0184028. PMID: 28859141; PMCID: PMC5578652.
    Citations: 5     Fields:    Translation:AnimalsCells
  29. Couto JA, Konczyk DJ, Vivero MP, Kozakewich HPW, Upton J, Fu X, Padwa BL, Mulliken JB, Warman ML, Greene AK. Somatic PIK3CA mutations are present in multiple tissues of facial infiltrating lipomatosis. Pediatr Res. 2017 Nov; 82(5):850-854. PMID: 28665924; PMCID: PMC5645230.
    Citations: 11     Fields:    Translation:HumansCells
  30. Tafaj O, Hann S, Ayturk U, Warman ML, Jüppner H. Mice maintain predominantly maternal Gas expression throughout life in brown fat tissue (BAT), but not other tissues. Bone. 2017 Oct; 103:177-187. PMID: 28694163.
    Citations: 3     Fields:    Translation:Animals
  31. Rees HA, Komor AC, Yeh WH, Caetano-Lopes J, Warman M, Edge ASB, Liu DR. Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery. Nat Commun. 2017 06 06; 8:15790. PMID: 28585549.
    Citations: 155     Fields:    Translation:AnimalsCells
  32. He Y, Zhang M, Huang AY, Cui Y, Bai D, Warman ML. Confocal imaging of mouse mandibular condyle cartilage. Sci Rep. 2017 03 07; 7:43848. PMID: 28266618.
    Citations: 4     Fields:    Translation:AnimalsCells
  33. Williams BO, Warman ML. CRISPR/CAS9 Technologies. J Bone Miner Res. 2017 May; 32(5):883-888. PMID: 28230927; PMCID: PMC5413371.
    Citations: 8     Fields:    Translation:HumansAnimals
  34. Couto JA, Huang AY, Konczyk DJ, Goss JA, Fishman SJ, Mulliken JB, Warman ML, Greene AK. Somatic MAP2K1 Mutations Are Associated with Extracranial Arteriovenous Malformation. Am J Hum Genet. 2017 Mar 02; 100(3):546-554. PMID: 28190454; PMCID: PMC5339083.
    Citations: 64     Fields:    Translation:HumansCells
  35. Couto JA, Ayturk UM, Konczyk DJ, Goss JA, Huang AY, Hann S, Reeve JL, Liang MG, Bischoff J, Warman ML, Greene AK. A somatic GNA11 mutation is associated with extremity capillary malformation and overgrowth. Angiogenesis. 2017 Aug; 20(3):303-306. PMID: 28120216; PMCID: PMC5511772.
    Citations: 34     Fields:    Translation:HumansCells
  36. Li L, Newton PT, Bouderlique T, Sejnohova M, Zikmund T, Kozhemyakina E, Xie M, Krivanek J, Kaiser J, Qian H, Dyachuk V, Lassar AB, Warman ML, Barenius B, Adameyko I, Chagin AS. Superficial cells are self-renewing chondrocyte progenitors, which form the articular cartilage in juvenile mice. FASEB J. 2017 03; 31(3):1067-1084. PMID: 27965322; PMCID: PMC5295727.
    Citations: 42     Fields:    Translation:AnimalsCells
  37. Zhang M, Mani SB, He Y, Hall AM, Xu L, Li Y, Zurakowski D, Jay GD, Warman ML. Induced superficial chondrocyte death reduces catabolic cartilage damage in murine posttraumatic osteoarthritis. J Clin Invest. 2016 08 01; 126(8):2893-902. PMID: 27427985; PMCID: PMC4966316.
    Citations: 41     Fields:    Translation:AnimalsCells
  38. Jacobsen CM, Schwartz MA, Roberts HJ, Lim KE, Spevak L, Boskey AL, Zurakowski D, Robling AG, Warman ML. Enhanced Wnt signaling improves bone mass and strength, but not brittleness, in the Col1a1(+/mov13) mouse model of type I Osteogenesis Imperfecta. Bone. 2016 09; 90:127-32. PMID: 27297606; PMCID: PMC4985001.
    Citations: 12     Fields:    Translation:AnimalsCells
  39. Ayturk UM, Couto JA, Hann S, Mulliken JB, Williams KL, Huang AY, Fishman SJ, Boyd TK, Kozakewich HPW, Bischoff J, Greene AK, Warman ML. Somatic Activating Mutations in GNAQ and GNA11 Are Associated with Congenital Hemangioma. Am J Hum Genet. 2016 06 02; 98(6):1271. PMID: 27259057; PMCID: PMC4908183.
    Citations: 16     Fields:    
  40. Masci M, Wang M, Imbert L, Barnes AM, Spevak L, Lukashova L, Huang Y, Ma Y, Marini JC, Jacobsen CM, Warman ML, Boskey AL. Bone mineral properties in growing Col1a2(+/G610C) mice, an animal model of osteogenesis imperfecta. Bone. 2016 06; 87:120-9. PMID: 27083399.
    Citations: 14     Fields:    Translation:AnimalsCells
  41. Ayturk UM, Couto JA, Hann S, Mulliken JB, Williams KL, Huang AY, Fishman SJ, Boyd TK, Kozakewich HP, Bischoff J, Greene AK, Warman ML. Somatic Activating Mutations in GNAQ and GNA11 Are Associated with Congenital Hemangioma. Am J Hum Genet. 2016 Apr 07; 98(4):789-95. PMID: 27058448; PMCID: PMC4833432.
    Citations: 39     Fields:    Translation:HumansCells
  42. Huang W, Li Q, Amiry-Moghaddam M, Hokama M, Sardi SH, Nagao M, Warman ML, Olsen BR. Critical Endothelial Regulation by LRP5 during Retinal Vascular Development. PLoS One. 2016; 11(3):e0152833. PMID: 27031698.
    Citations: 10     Fields:    Translation:AnimalsCells
  43. Couto JA, Huang L, Vivero MP, Kamitaki N, Maclellan RA, Mulliken JB, Bischoff J, Warman ML, Greene AK. Endothelial Cells from Capillary Malformations Are Enriched for Somatic GNAQ Mutations. Plast Reconstr Surg. 2016 Jan; 137(1):77e-82e. PMID: 26368330; PMCID: PMC5242181.
    Citations: 43     Fields:    Translation:HumansCells
  44. Niziolek PJ, Bullock W, Warman ML, Robling AG. Missense Mutations in LRP5 Associated with High Bone Mass Protect the Mouse Skeleton from Disuse- and Ovariectomy-Induced Osteopenia. PLoS One. 2015; 10(11):e0140775. PMID: 26554834.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  45. Hill A, Waller KA, Cui Y, Allen JM, Smits P, Zhang LX, Ayturk UM, Hann S, Lessard SG, Zurakowski D, Warman ML, Jay GD. Lubricin restoration in a mouse model of congenital deficiency. Arthritis Rheumatol. 2015 Nov; 67(11):3070-81. PMID: 26216721; PMCID: PMC4626303.
    Citations: 14     Fields:    Translation:AnimalsCells
  46. Niziolek PJ, MacDonald BT, Kedlaya R, Zhang M, Bellido T, He X, Warman ML, Robling AG. High Bone Mass-Causing Mutant LRP5 Receptors Are Resistant to Endogenous Inhibitors In Vivo. J Bone Miner Res. 2015 Oct; 30(10):1822-30. PMID: 25808845; PMCID: PMC4580530.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  47. Couto JA, Vivero MP, Upton J, Padwa BL, Warman ML, Mulliken JB, Greene AK. Facial Infiltrating Lipomatosis Contains Somatic PIK3CA Mutations in Multiple Tissues. Plast Reconstr Surg. 2015 Oct; 136(4 Suppl):72-3. PMID: 26397580.
  48. Bonafe L, Cormier-Daire V, Hall C, Lachman R, Mortier G, Mundlos S, Nishimura G, Sangiorgi L, Savarirayan R, Sillence D, Spranger J, Superti-Furga A, Warman M, Unger S. Nosology and classification of genetic skeletal disorders: 2015 revision. Am J Med Genet A. 2015 Dec; 167A(12):2869-92. PMID: 26394607.
    Citations: 168     Fields:    Translation:Humans
  49. Kozhemyakina E, Zhang M, Ionescu A, Ayturk UM, Ono N, Kobayashi A, Kronenberg H, Warman ML, Lassar AB. Identification of a Prg4-expressing articular cartilage progenitor cell population in mice. Arthritis Rheumatol. 2015 May; 67(5):1261-73. PMID: 25603997; PMCID: PMC4414823.
    Citations: 99     Fields:    Translation:AnimalsCells
  50. Tosi LL, Warman ML. Mechanistic and therapeutic insights gained from studying rare skeletal diseases. Bone. 2015 Jul; 76:67-75. PMID: 25819040.
    Citations: 9     Fields:    Translation:HumansCells
  51. Wang SR, Jacobsen CM, Carmichael H, Edmund AB, Robinson JW, Olney RC, Miller TC, Moon JE, Mericq V, Potter LR, Warman ML, Hirschhorn JN, Dauber A. Heterozygous mutations in natriuretic peptide receptor-B (NPR2) gene as a cause of short stature. Hum Mutat. 2015 Apr; 36(4):474-81. PMID: 25703509; PMCID: PMC4382411.
    Citations: 35     Fields:    Translation:Humans
  52. Couto JA, Vivero MP, Kozakewich HP, Taghinia AH, Mulliken JB, Warman ML, Greene AK. A somatic MAP3K3 mutation is associated with verrucous venous malformation. Am J Hum Genet. 2015 Mar 05; 96(3):480-6. PMID: 25728774; PMCID: PMC4375628.
    Citations: 33     Fields:    Translation:Humans
  53. Luks VL, Kamitaki N, Vivero MP, Uller W, Rab R, Bovée JV, Rialon KL, Guevara CJ, Alomari AI, Greene AK, Fishman SJ, Kozakewich HP, Maclellan RA, Mulliken JB, Rahbar R, Spencer SA, Trenor CC, Upton J, Zurakowski D, Perkins JA, Kirsh A, Bennett JT, Dobyns WB, Kurek KC, Warman ML, McCarroll SA, Murillo R. Lymphatic and other vascular malformative/overgrowth disorders are caused by somatic mutations in PIK3CA. J Pediatr. 2015 Apr; 166(4):1048-54.e1-5. PMID: 25681199; PMCID: PMC4498659.
    Citations: 135     Fields:    Translation:Humans
  54. Ai M, Cui Y, Sy MS, Lee DM, Zhang LX, Larson KM, Kurek KC, Jay GD, Warman ML. Anti-lubricin monoclonal antibodies created using lubricin-knockout mice immunodetect lubricin in several species and in patients with healthy and diseased joints. PLoS One. 2015; 10(2):e0116237. PMID: 25642942.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  55. Boscolo E, Coma S, Luks VL, Greene AK, Klagsbrun M, Warman ML, Bischoff J. AKT hyper-phosphorylation associated with PI3K mutations in lymphatic endothelial cells from a patient with lymphatic malformation. Angiogenesis. 2015 Apr; 18(2):151-62. PMID: 25424831; PMCID: PMC4366356.
    Citations: 46     Fields:    Translation:HumansCells
  56. Cui Y, Niziolek PJ, MacDonald BT, Alenina N, Matthes S, Jacobsen CM, Conlon RA, Brommage R, Powell DR, He X, Bader M, Williams BO, Warman ML, Robling AG. Reply to Lrp5 regulation of bone mass and gut serotonin synthesis. Nat Med. 2014 Nov; 20(11):1229-30. PMID: 25375917; PMCID: PMC6032990.
    Citations: 12     Fields:    Translation:Animals
  57. Jacobsen CM, Barber LA, Ayturk UM, Roberts HJ, Deal LE, Schwartz MA, Weis M, Eyre D, Zurakowski D, Robling AG, Warman ML. Targeting the LRP5 pathway improves bone properties in a mouse model of osteogenesis imperfecta. J Bone Miner Res. 2014 Oct; 29(10):2297-306. PMID: 24677211.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  58. Bennike T, Ayturk U, Haslauer CM, Froehlich JW, Proffen BL, Barnaby O, Birkelund S, Murray MM, Warman ML, Stensballe A, Steen H. A normative study of the synovial fluid proteome from healthy porcine knee joints. J Proteome Res. 2014 Oct 03; 13(10):4377-87. PMID: 25160569.
    Citations: 29     Fields:    Translation:AnimalsCells
  59. Bowen ME, Ayturk UM, Kurek KC, Yang W, Warman ML. SHP2 regulates chondrocyte terminal differentiation, growth plate architecture and skeletal cell fates. PLoS Genet. 2014; 10(5):e1004364. PMID: 24875294.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  60. Maclellan RA, Luks VL, Vivero MP, Mulliken JB, Zurakowski D, Padwa BL, Warman ML, Greene AK, Kurek KC. PIK3CA activating mutations in facial infiltrating lipomatosis. Plast Reconstr Surg. 2014 Jan; 133(1):12e-19e. PMID: 24374682.
    Citations: 27     Fields:    Translation:HumansCells
  61. Bükülmez H, Khan F, Bartels CF, Murakami S, Ortiz-Lopez A, Sattar A, Haqqi TM, Warman ML. Protective effects of C-type natriuretic peptide on linear growth and articular cartilage integrity in a mouse model of inflammatory arthritis. Arthritis Rheumatol. 2014 Jan; 66(1):78-89. PMID: 24449577; PMCID: PMC4034591.
    Citations: 10     Fields:    Translation:AnimalsCells
  62. Kedlaya R, Veera S, Horan DJ, Moss RE, Ayturk UM, Jacobsen CM, Bowen ME, Paszty C, Warman ML, Robling AG. Sclerostin inhibition reverses skeletal fragility in an Lrp5-deficient mouse model of OPPG syndrome. Sci Transl Med. 2013 Nov 13; 5(211):211ra158. PMID: 24225945.
    Citations: 41     Fields:    Translation:Animals
  63. Ayturk UM, Jacobsen CM, Christodoulou DC, Gorham J, Seidman JG, Seidman CE, Robling AG, Warman ML. An RNA-seq protocol to identify mRNA expression changes in mouse diaphyseal bone: applications in mice with bone property altering Lrp5 mutations. J Bone Miner Res. 2013 Oct; 28(10):2081-93. PMID: 23553928; PMCID: PMC3743099.
    Citations: 43     Fields:    Translation:HumansAnimals
  64. Hann S, Kvenvold L, Newby BN, Hong M, Warman ML. A Wisp3 Cre-knockin allele produces efficient recombination in spermatocytes during early prophase of meiosis I. PLoS One. 2013; 8(9):e75116. PMID: 24040393.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  65. Allen JM, McGlinn E, Hill A, Warman ML. Autopodial development is selectively impaired by misexpression of chordin-like 1 in the chick limb. Dev Biol. 2013 Sep 01; 381(1):159-69. PMID: 23764427.
    Citations: 3     Fields:    Translation:AnimalsCells
  66. Waller KA, Zhang LX, Elsaid KA, Fleming BC, Warman ML, Jay GD. Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis. Proc Natl Acad Sci U S A. 2013 Apr 09; 110(15):5852-7. PMID: 23530215.
    Citations: 65     Fields:    Translation:AnimalsCells
  67. Adams A, McBratney-Owen B, Newby B, Bowen ME, Olsen BR, Warman ML. Presphenoidal synchondrosis fusion in DBA/2J mice. Mamm Genome. 2013 Feb; 24(1-2):54-62. PMID: 23179633.
    Citations: 1     Fields:    Translation:AnimalsCells
  68. Kim S, Hill A, Warman ML, Smits P. Golgi disruption and early embryonic lethality in mice lacking USO1. PLoS One. 2012; 7(11):e50530. PMID: 23185636.
    Citations: 6     Fields:    Translation:AnimalsCells
  69. Yuan Q, Chiquet BT, Devault L, Warman ML, Nakamura Y, Swindell EC, Hecht JT. Craniofacial abnormalities result from knock down of nonsyndromic clefting gene, crispld2, in zebrafish. Genesis. 2012 Dec; 50(12):871-81. PMID: 22887593.
    Citations: 9     Fields:    Translation:AnimalsCells
  70. Garcia Segarra N, Mittaz L, Campos-Xavier AB, Bartels CF, Tuysuz B, Alanay Y, Cimaz R, Cormier-Daire V, Di Rocco M, Duba HC, Elcioglu NH, Forzano F, Hospach T, Kilic E, Kuemmerle-Deschner JB, Mortier G, Mrusek S, Nampoothiri S, Obersztyn E, Pauli RM, Selicorni A, Tenconi R, Unger S, Utine GE, Wright M, Zabel B, Warman ML, Superti-Furga A, Bonafé L. The diagnostic challenge of progressive pseudorheumatoid dysplasia (PPRD): a review of clinical features, radiographic features, and WISP3 mutations in 63 affected individuals. Am J Med Genet C Semin Med Genet. 2012 Aug 15; 160C(3):217-29. PMID: 22791401.
    Citations: 32     Fields:    Translation:HumansCells
  71. Niziolek PJ, Warman ML, Robling AG. Mechanotransduction in bone tissue: The A214V and G171V mutations in Lrp5 enhance load-induced osteogenesis in a surface-selective manner. Bone. 2012 Sep; 51(3):459-65. PMID: 22750014.
    Citations: 28     Fields:    Translation:AnimalsCells
  72. Kurek KC, Luks VL, Ayturk UM, Alomari AI, Fishman SJ, Spencer SA, Mulliken JB, Bowen ME, Yamamoto GL, Kozakewich HP, Warman ML. Somatic mosaic activating mutations in PIK3CA cause CLOVES syndrome. Am J Hum Genet. 2012 Jun 08; 90(6):1108-15. PMID: 22658544.
    Citations: 160     Fields:    Translation:HumansCells
  73. Korvala J, Jüppner H, Mäkitie O, Sochett E, Schnabel D, Mora S, Bartels CF, Warman ML, Deraska D, Cole WG, Hartikka H, Ala-Kokko L, Männikkö M. Mutations in LRP5 cause primary osteoporosis without features of OI by reducing Wnt signaling activity. BMC Med Genet. 2012 Apr 10; 13:26. PMID: 22487062.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  74. Drewniak EI, Jay GD, Fleming BC, Zhang L, Warman ML, Crisco JJ. Cyclic loading increases friction and changes cartilage surface integrity in lubricin-mutant mouse knees. Arthritis Rheum. 2012 Feb; 64(2):465-73. PMID: 21905020; PMCID: PMC3252402.
    Citations: 19     Fields:    Translation:Animals
  75. Bowen ME, Henke K, Siegfried KR, Warman ML, Harris MP. Efficient mapping and cloning of mutations in zebrafish by low-coverage whole-genome sequencing. Genetics. 2012 Mar; 190(3):1017-24. PMID: 22174069.
    Citations: 46     Fields:    Translation:Animals
  76. Boyden ED, Campos-Xavier AB, Kalamajski S, Cameron TL, Suarez P, Tanackovic G, Tanackovich G, Andria G, Ballhausen D, Briggs MD, Hartley C, Cohn DH, Davidson HR, Hall C, Ikegawa S, Jouk PS, König R, Megarbané A, Nishimura G, Lachman RS, Mortier G, Rimoin DL, Rogers RC, Rossi M, Sawada H, Scott R, Unger S, Valadares ER, Bateman JF, Warman ML, Superti-Furga A, Bonafé L. Recurrent dominant mutations affecting two adjacent residues in the motor domain of the monomeric kinesin KIF22 result in skeletal dysplasia and joint laxity. Am J Hum Genet. 2011 Dec 09; 89(6):767-72. PMID: 22152678; PMCID: PMC3234368.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  77. Klopocki E, Lohan S, Doelken SC, Stricker S, Ockeloen CW, Soares Thiele de Aguiar R, Lezirovitz K, Mingroni Netto RC, Jamsheer A, Shah H, Kurth I, Habenicht R, Warman M, Devriendt K, Kordass U, Hempel M, Rajab A, Mäkitie O, Naveed M, Radhakrishna U, Antonarakis SE, Horn D, Mundlos S. Duplications of BHLHA9 are associated with ectrodactyly and tibia hemimelia inherited in non-Mendelian fashion. J Med Genet. 2012 Feb; 49(2):119-25. PMID: 22147889.
    Citations: 35     Fields:    Translation:HumansAnimals
  78. Nakamura Y, He X, Kato H, Wakitani S, Kobayashi T, Watanabe S, Iida A, Tahara H, Warman ML, Watanapokasin R, Postlethwait JH. Sox9 is upstream of microRNA-140 in cartilage. Appl Biochem Biotechnol. 2012 Jan; 166(1):64-71. PMID: 22052544.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  79. Niziolek PJ, Farmer TL, Cui Y, Turner CH, Warman ML, Robling AG. High-bone-mass-producing mutations in the Wnt signaling pathway result in distinct skeletal phenotypes. Bone. 2011 Nov; 49(5):1010-9. PMID: 21855668.
    Citations: 40     Fields:    Translation:AnimalsCells
  80. Reuvers J, Thoreson AR, Zhao C, Zhang L, Jay GD, An KN, Warman ML, Amadio PC. The mechanical properties of tail tendon fascicles from lubricin knockout, wild type and heterozygous mice. J Struct Biol. 2011 Oct; 176(1):41-5. PMID: 21821131.
    Citations: 9     Fields:    Translation:Animals
  81. Cui Y, Niziolek PJ, MacDonald BT, Zylstra CR, Alenina N, Robinson DR, Zhong Z, Matthes S, Jacobsen CM, Conlon RA, Brommage R, Liu Q, Mseeh F, Powell DR, Yang QM, Zambrowicz B, Gerrits H, Gossen JA, He X, Bader M, Williams BO, Warman ML, Robling AG. Lrp5 functions in bone to regulate bone mass. Nat Med. 2011 Jun; 17(6):684-91. PMID: 21602802.
    Citations: 218     Fields:    Translation:AnimalsCells
  82. Olson JC, Kurek KC, Mehta HP, Warman ML, Snyder BD. Expansion thoracoplasty affects lung growth and morphology in a rabbit model: a pilot study. Clin Orthop Relat Res. 2011 May; 469(5):1375-82. PMID: 21424837; PMCID: PMC3069277.
    Citations: 5     Fields:    Translation:AnimalsCells
  83. Bowen ME, Boyden ED, Holm IA, Campos-Xavier B, Bonafé L, Superti-Furga A, Ikegawa S, Cormier-Daire V, Bovée JV, Pansuriya TC, de Sousa SB, Savarirayan R, Andreucci E, Vikkula M, Garavelli L, Pottinger C, Ogino T, Sakai A, Regazzoni BM, Wuyts W, Sangiorgi L, Pedrini E, Zhu M, Kozakewich HP, Kasser JR, Seidman JG, Kurek KC, Warman ML. Loss-of-function mutations in PTPN11 cause metachondromatosis, but not Ollier disease or Maffucci syndrome. PLoS Genet. 2011 Apr; 7(4):e1002050. PMID: 21533187.
    Citations: 43     Fields:    Translation:HumansCells
  84. Warman ML, Cormier-Daire V, Hall C, Krakow D, Lachman R, LeMerrer M, Mortier G, Mundlos S, Nishimura G, Rimoin DL, Robertson S, Savarirayan R, Sillence D, Spranger J, Unger S, Zabel B, Superti-Furga A. Nosology and classification of genetic skeletal disorders: 2010 revision. Am J Med Genet A. 2011 May; 155A(5):943-68. PMID: 21438135.
    Citations: 215     Fields:    Translation:Humans
  85. Nakamura Y, Yamamoto K, He X, Otsuki B, Kim Y, Murao H, Soeda T, Tsumaki N, Deng JM, Zhang Z, Behringer RR, Crombrugghe Bd, Postlethwait JH, Warman ML, Nakamura T, Akiyama H. Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25. Nat Commun. 2011; 2:251. PMID: 21427722.
    Citations: 68     Fields:    Translation:AnimalsCells
  86. Badadani M, Nalbandian A, Watts GD, Vesa J, Kitazawa M, Su H, Tanaja J, Dec E, Wallace DC, Mukherjee J, Caiozzo V, Warman M, Kimonis VE. VCP associated inclusion body myopathy and paget disease of bone knock-in mouse model exhibits tissue pathology typical of human disease. PLoS One. 2010 Oct 05; 5(10). PMID: 20957154.
    Citations: 64     Fields:    Translation:Animals
  87. Kohrs RT, Zhao C, Sun YL, Jay GD, Zhang L, Warman ML, An KN, Amadio PC. Tendon fascicle gliding in wild type, heterozygous, and lubricin knockout mice. J Orthop Res. 2011 Mar; 29(3):384-9. PMID: 20886657.
    Citations: 24     Fields:    Translation:Animals
  88. Kurek KC, Del Mare S, Salah Z, Abdeen S, Sadiq H, Lee SH, Gaudio E, Zanesi N, Jones KB, DeYoung B, Amir G, Gebhardt M, Warman M, Stein GS, Stein JL, Lian JB, Aqeilan RI. Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expression. Cancer Res. 2010 Jul 01; 70(13):5577-86. PMID: 20530675.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  89. Fernando CA, Conrad PA, Bartels CF, Marques T, To M, Balow SA, Nakamura Y, Warman ML. Temporal and spatial expression of CCN genes in zebrafish. Dev Dyn. 2010 Jun; 239(6):1755-67. PMID: 20503371; PMCID: PMC3133677.
    Citations: 13     Fields:    Translation:AnimalsCells
  90. Coles JM, Zhang L, Blum JJ, Warman ML, Jay GD, Guilak F, Zauscher S. Loss of cartilage structure, stiffness, and frictional properties in mice lacking PRG4. Arthritis Rheum. 2010 Jun; 62(6):1666-74. PMID: 20191580; PMCID: PMC2943386.
    Citations: 57     Fields:    Translation:Animals
  91. Kiener HP, Watts GF, Cui Y, Wright J, Thornhill TS, Sköld M, Behar SM, Niederreiter B, Lu J, Cernadas M, Coyle AJ, Sims GP, Smolen J, Warman ML, Brenner MB, Lee DM. Synovial fibroblasts self-direct multicellular lining architecture and synthetic function in three-dimensional organ culture. Arthritis Rheum. 2010 Mar; 62(3):742-52. PMID: 20131230.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  92. Smits P, Bolton AD, Funari V, Hong M, Boyden ED, Lu L, Manning DK, Dwyer ND, Moran JL, Prysak M, Merriman B, Nelson SF, Bonafé L, Superti-Furga A, Ikegawa S, Krakow D, Cohn DH, Kirchhausen T, Warman ML, Beier DR. Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210. N Engl J Med. 2010 Jan 21; 362(3):206-16. PMID: 20089971; PMCID: PMC3108191.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  93. Nakamura Y, Cui Y, Fernando C, Kutz WE, Warman ML. Normal growth and development in mice over-expressing the CCN family member WISP3. J Cell Commun Signal. 2009 Jun; 3(2):105-13. PMID: 19401829.
    Citations: 10     
  94. Chung BD, Kayserili H, Ai M, Freudenberg J, Uzümcü A, Uyguner O, Bartels CF, Höning S, Ramirez A, Hanisch FG, Nürnberg G, Nürnberg P, Warman ML, Wollnik B, Kubisch C, Netzer C. A mutation in the signal sequence of LRP5 in a family with an osteoporosis-pseudoglioma syndrome (OPPG)-like phenotype indicates a novel disease mechanism for trinucleotide repeats. Hum Mutat. 2009 Apr; 30(4):641-8. PMID: 19177549.
    Citations: 14     Fields:    Translation:HumansCells
  95. Neilson DE, Adams MD, Orr CM, Schelling DK, Eiben RM, Kerr DS, Anderson J, Bassuk AG, Bye AM, Childs AM, Clarke A, Crow YJ, Di Rocco M, Dohna-Schwake C, Dueckers G, Fasano AE, Gika AD, Gionnis D, Gorman MP, Grattan-Smith PJ, Hackenberg A, Kuster A, Lentschig MG, Lopez-Laso E, Marco EJ, Mastroyianni S, Perrier J, Schmitt-Mechelke T, Servidei S, Skardoutsou A, Uldall P, van der Knaap MS, Goglin KC, Tefft DL, Aubin C, de Jager P, Hafler D, Warman ML. Infection-triggered familial or recurrent cases of acute necrotizing encephalopathy caused by mutations in a component of the nuclear pore, RANBP2. Am J Hum Genet. 2009 Jan; 84(1):44-51. PMID: 19118815.
    Citations: 88     Fields:    Translation:HumansCells
  96. Matsushita T, Wilcox WR, Chan YY, Kawanami A, Bükülmez H, Balmes G, Krejci P, Mekikian PB, Otani K, Yamaura I, Warman ML, Givol D, Murakami S. FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway. Hum Mol Genet. 2009 Jan 15; 18(2):227-40. PMID: 18923003; PMCID: PMC2638772.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  97. Nakamura Y, He X, Kobayashi T, Yan YL, Postlethwait JH, Warman ML. Unique roles of microRNA140 and its host gene WWP2 in cartilage biology. J Musculoskelet Neuronal Interact. 2008 Oct-Dec; 8(4):321-2. PMID: 19147957.
    Citations: 9     Fields:    Translation:HumansAnimals
  98. Balemans W, Piters E, Cleiren E, Ai M, Van Wesenbeeck L, Warman ML, Van Hul W. The binding between sclerostin and LRP5 is altered by DKK1 and by high-bone mass LRP5 mutations. Calcif Tissue Int. 2008 Jun; 82(6):445-53. PMID: 18521528.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  99. Jay GD, Torres JR, Rhee DK, Helminen HJ, Hytinnen MM, Cha CJ, Elsaid K, Kim KS, Cui Y, Warman ML. Association between friction and wear in diarthrodial joints lacking lubricin. Arthritis Rheum. 2007 Nov; 56(11):3662-9. PMID: 17968947; PMCID: PMC2688668.
    Citations: 89     Fields:    Translation:HumansAnimals
  100. Nakamura Y, Weidinger G, Liang JO, Aquilina-Beck A, Tamai K, Moon RT, Warman ML. The CCN family member Wisp3, mutant in progressive pseudorheumatoid dysplasia, modulates BMP and Wnt signaling. J Clin Invest. 2007 Oct; 117(10):3075-86. PMID: 17823661; PMCID: PMC1964511.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  101. Jay GD, Torres JR, Warman ML, Laderer MC, Breuer KS. The role of lubricin in the mechanical behavior of synovial fluid. Proc Natl Acad Sci U S A. 2007 Apr 10; 104(15):6194-9. PMID: 17404241; PMCID: PMC1851076.
    Citations: 69     Fields:    Translation:HumansAnimals
  102. Sawakami K, Robling AG, Ai M, Pitner ND, Liu D, Warden SJ, Li J, Maye P, Rowe DW, Duncan RL, Warman ML, Turner CH. The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment. J Biol Chem. 2006 Aug 18; 281(33):23698-711. PMID: 16790443.
    Citations: 192     Fields:    Translation:HumansAnimalsCells
  103. Okajima K, Warman ML, Byrne LC, Kerr DS. Somatic mosaicism in a male with an exon skipping mutation in PDHA1 of the pyruvate dehydrogenase complex results in a milder phenotype. Mol Genet Metab. 2006 Feb; 87(2):162-8. PMID: 16412675.
    Citations: 11     Fields:    Translation:HumansCells
  104. Bukulmez H, Matthews AL, Sullivan CM, Chen C, Kraay MJ, Elston RC, Moskowitz RW, Goldberg VM, Warman ML. Hip joint replacement surgery for idiopathic osteoarthritis aggregates in families. Arthritis Res Ther. 2006; 8(1):R25. PMID: 16507126; PMCID: PMC1526562.
    Citations: 4     Fields:    Translation:Humans
  105. Olney RC, Bükülmez H, Bartels CF, Prickett TC, Espiner EA, Potter LR, Warman ML. Heterozygous mutations in natriuretic peptide receptor-B (NPR2) are associated with short stature. J Clin Endocrinol Metab. 2006 Apr; 91(4):1229-32. PMID: 16384845.
    Citations: 60     Fields:    Translation:Humans
  106. Clément-Lacroix P, Ai M, Morvan F, Roman-Roman S, Vayssière B, Belleville C, Estrera K, Warman ML, Baron R, Rawadi G. Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice. Proc Natl Acad Sci U S A. 2005 Nov 29; 102(48):17406-11. PMID: 16293698; PMCID: PMC1297659.
    Citations: 172     Fields:    Translation:AnimalsCells
  107. Rhee DK, Marcelino J, Al-Mayouf S, Schelling DK, Bartels CF, Cui Y, Laxer R, Goldbach-Mansky R, Warman ML. Consequences of disease-causing mutations on lubricin protein synthesis, secretion, and post-translational processing. J Biol Chem. 2005 Sep 02; 280(35):31325-32. PMID: 16000300.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  108. Jakkula E, Melkoniemi M, Kiviranta I, Lohiniva J, Räinä SS, Perälä M, Warman ML, Ahonen K, Kröger H, Göring HH, Ala-Kokko L. The role of sequence variations within the genes encoding collagen II, IX and XI in non-syndromic, early-onset osteoarthritis. Osteoarthritis Cartilage. 2005 Jun; 13(6):497-507. PMID: 15922184.
    Citations: 17     Fields:    Translation:Humans
  109. Ai M, Holmen SL, Van Hul W, Williams BO, Warman ML. Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling. Mol Cell Biol. 2005 Jun; 25(12):4946-55. PMID: 15923613; PMCID: PMC1140571.
    Citations: 94     Fields:    Translation:HumansAnimalsCells
  110. Elsaid KA, Jay GD, Warman ML, Rhee DK, Chichester CO. Association of articular cartilage degradation and loss of boundary-lubricating ability of synovial fluid following injury and inflammatory arthritis. Arthritis Rheum. 2005 Jun; 52(6):1746-55. PMID: 15934070.
    Citations: 57     Fields:    Translation:HumansAnimals
  111. Rhee DK, Marcelino J, Baker M, Gong Y, Smits P, Lefebvre V, Jay GD, Stewart M, Wang H, Warman ML, Carpten JD. The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth. J Clin Invest. 2005 Mar; 115(3):622-31. PMID: 15719068; PMCID: PMC548698.
    Citations: 222     Fields:    Translation:HumansAnimalsCells
  112. Kutz WE, Gong Y, Warman ML. WISP3, the gene responsible for the human skeletal disease progressive pseudorheumatoid dysplasia, is not essential for skeletal function in mice. Mol Cell Biol. 2005 Jan; 25(1):414-21. PMID: 15601861; PMCID: PMC538768.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  113. Holmen SL, Giambernardi TA, Zylstra CR, Buckner-Berghuis BD, Resau JH, Hess JF, Glatt V, Bouxsein ML, Ai M, Warman ML, Williams BO. Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6. J Bone Miner Res. 2004 Dec; 19(12):2033-40. PMID: 15537447.
    Citations: 145     Fields:    Translation:HumansAnimalsCells
  114. Falk MJ, Feiler HS, Neilson DE, Maxwell K, Lee JV, Segall SK, Robin NH, Wilhelmsen KC, Träskelin AL, Kolehmainen J, Lehesjoki AE, Wiznitzer M, Warman ML. Cohen syndrome in the Ohio Amish. Am J Med Genet A. 2004 Jul 01; 128A(1):23-8. PMID: 15211651.
    Citations: 8     Fields:    Translation:HumansCells
  115. Bartels CF, Bükülmez H, Padayatti P, Rhee DK, van Ravenswaaij-Arts C, Pauli RM, Mundlos S, Chitayat D, Shih LY, Al-Gazali LI, Kant S, Cole T, Morton J, Cormier-Daire V, Faivre L, Lees M, Kirk J, Mortier GR, Leroy J, Zabel B, Kim CA, Crow Y, Braverman NE, van den Akker F, Warman ML. Mutations in the transmembrane natriuretic peptide receptor NPR-B impair skeletal growth and cause acromesomelic dysplasia, type Maroteaux. Am J Hum Genet. 2004 Jul; 75(1):27-34. PMID: 15146390; PMCID: PMC1182004.
    Citations: 114     Fields:    Translation:HumansCells
  116. Neilson DE, Feiler HS, Wilhelmsen KC, Lynn A, Eiben RM, Kerr DS, Warman ML. Autosomal dominant acute necrotizing encephalopathy maps to 2q12.1-2q13. Ann Neurol. 2004 Feb; 55(2):291-4. PMID: 14755735.
    Citations: 8     Fields:    Translation:HumansCells
  117. Hanks S, Adams S, Douglas J, Arbour L, Atherton DJ, Balci S, Bode H, Campbell ME, Feingold M, Keser G, Kleijer W, Mancini G, McGrath JA, Muntoni F, Nanda A, Teare MD, Warman M, Pope FM, Superti-Furga A, Futreal PA, Rahman N. Mutations in the gene encoding capillary morphogenesis protein 2 cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Am J Hum Genet. 2003 Oct; 73(4):791-800. PMID: 14508707; PMCID: PMC1180602.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  118. Neilson DE, Eiben RM, Waniewski S, Hoppel CL, Varnes ME, Bangert BA, Wiznitzer M, Warman ML, Kerr DS. Autosomal dominant acute necrotizing encephalopathy. Neurology. 2003 Jul 22; 61(2):226-30. PMID: 12874403.
    Citations: 20     Fields:    Translation:HumansCells
  119. Melkoniemi M, Koillinen H, Männikkö M, Warman ML, Pihlajamaa T, Kääriäinen H, Rautio J, Hukki J, Stofko JA, Cisneros GJ, Krakow D, Cohn DH, Kere J, Ala-Kokko L. Collagen XI sequence variations in nonsyndromic cleft palate, Robin sequence and micrognathia. Eur J Hum Genet. 2003 Mar; 11(3):265-70. PMID: 12673280.
    Citations: 18     Fields:    Translation:Humans
  120. Falk MJ, Heeger S, Lynch KA, DeCaro KR, Bohach D, Gibson KS, Warman ML. Intravenous bisphosphonate therapy in children with osteogenesis imperfecta. Pediatrics. 2003 Mar; 111(3):573-8. PMID: 12612238.
    Citations: 20     Fields:    Translation:HumansCTClinical Trials
  121. Savarirayan R, White SM, Goodman FR, Graham JM, Delatycki MB, Lachman RS, Rimoin DL, Everman DB, Warman ML. Broad phenotypic spectrum caused by an identical heterozygous CDMP-1 mutation in three unrelated families. Am J Med Genet A. 2003 Mar 01; 117A(2):136-42. PMID: 12567410.
    Citations: 19     Fields:    Translation:Humans
  122. Van Wesenbeeck L, Cleiren E, Gram J, Beals RK, Bénichou O, Scopelliti D, Key L, Renton T, Bartels C, Gong Y, Warman ML, De Vernejoul MC, Bollerslev J, Van Hul W. Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density. Am J Hum Genet. 2003 Mar; 72(3):763-71. PMID: 12579474; PMCID: PMC1180253.
    Citations: 165     Fields:    Translation:HumansAnimalsCells
  123. Everman DB, Bartels CF, Yang Y, Yanamandra N, Goodman FR, Mendoza-Londono JR, Savarirayan R, White SM, Graham JM, Gale RP, Svarch E, Newman WG, Kleckers AR, Francomano CA, Govindaiah V, Singh L, Morrison S, Thomas JT, Warman ML. The mutational spectrum of brachydactyly type C. Am J Med Genet. 2002 Oct 15; 112(3):291-6. PMID: 12357473.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  124. McCready ME, Sweeney E, Fryer AE, Donnai D, Baig A, Racacho L, Warman ML, Hunter AG, Bulman DE. A novel mutation in the IHH gene causes brachydactyly type A1: a 95-year-old mystery resolved. Hum Genet. 2002 Oct; 111(4-5):368-75. PMID: 12384778.
    Citations: 13     Fields:    Translation:HumansCells
  125. Rahman N, Dunstan M, Teare MD, Hanks S, Edkins SJ, Hughes J, Bignell GR, Mancini G, Kleijer W, Campbell M, Keser G, Black C, Williams N, Arbour L, Warman M, Superti-Furga A, Futreal PA, Pope FM. The gene for juvenile hyaline fibromatosis maps to chromosome 4q21. Am J Hum Genet. 2002 Oct; 71(4):975-80. PMID: 12214284; PMCID: PMC378553.
    Citations: 19     Fields:    Translation:HumansCells
  126. Lindor NM, Kasperbauer JL, Hoffman AD, Parisi JE, Wang H, Warman M. Confirmation of existence of a new syndrome: LAPS syndrome. Am J Med Genet. 2002 Apr 22; 109(2):93-9. PMID: 11977156.
    Citations: 2     Fields:    Translation:Humans
  127. Warman ML. Significant difference of opinion regarding the role of noggin in fibrodysplasia ossificans progressiva. Am J Med Genet. 2002 Apr 22; 109(2):162; author reply 163-4. PMID: 11977169.
    Citations: 2     Fields:    Translation:HumansCells
  128. Brouillard P, Boon LM, Mulliken JB, Enjolras O, Ghassibé M, Warman ML, Tan OT, Olsen BR, Vikkula M. Mutations in a novel factor, glomulin, are responsible for glomuvenous malformations ("glomangiomas"). Am J Hum Genet. 2002 Apr; 70(4):866-74. PMID: 11845407; PMCID: PMC379115.
    Citations: 71     Fields:    Translation:HumansCells
  129. Gong Y, Slee RB, Fukai N, Rawadi G, Roman-Roman S, Reginato AM, Wang H, Cundy T, Glorieux FH, Lev D, Zacharin M, Oexle K, Marcelino J, Suwairi W, Heeger S, Sabatakos G, Apte S, Adkins WN, Allgrove J, Arslan-Kirchner M, Batch JA, Beighton P, Black GC, Boles RG, Boon LM, Borrone C, Brunner HG, Carle GF, Dallapiccola B, De Paepe A, Floege B, Halfhide ML, Hall B, Hennekam RC, Hirose T, Jans A, Jüppner H, Kim CA, Keppler-Noreuil K, Kohlschuetter A, LaCombe D, Lambert M, Lemyre E, Letteboer T, Peltonen L, Ramesar RS, Romanengo M, Somer H, Steichen-Gersdorf E, Steinmann B, Sullivan B, Superti-Furga A, Swoboda W, van den Boogaard MJ, Van Hul W, Vikkula M, Votruba M, Zabel B, Garcia T, Baron R, Olsen BR, Warman ML. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell. 2001 Nov 16; 107(4):513-23. PMID: 11719191.
    Citations: 763     Fields:    Translation:HumansAnimalsCells
  130. Jepsen KJ, Pennington DE, Lee YL, Warman M, Nadeau J. Bone brittleness varies with genetic background in A/J and C57BL/6J inbred mice. J Bone Miner Res. 2001 Oct; 16(10):1854-62. PMID: 11585350.
    Citations: 48     Fields:    Translation:Animals
  131. Marcelino J, Sciortino CM, Romero MF, Ulatowski LM, Ballock RT, Economides AN, Eimon PM, Harland RM, Warman ML. Human disease-causing NOG missense mutations: effects on noggin secretion, dimer formation, and bone morphogenetic protein binding. Proc Natl Acad Sci U S A. 2001 Sep 25; 98(20):11353-8. PMID: 11562478; PMCID: PMC58733.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  132. Warman ML. Human genetic insights into skeletal development, growth, and homeostasis. Clin Orthop Relat Res. 2000 Oct; (379 Suppl):S40-54. PMID: 11039750.
    Citations:    Fields:    Translation:HumansAnimals
  133. Truett GE, Heeger P, Mynatt RL, Truett AA, Walker JA, Warman ML. Preparation of PCR-quality mouse genomic DNA with hot sodium hydroxide and tris (HotSHOT). Biotechniques. 2000 Jul; 29(1):52, 54. PMID: 10907076.
    Citations: 542     Fields:    Translation:Animals
  134. Melkoniemi M, Brunner HG, Manouvrier S, Hennekam R, Superti-Furga A, Kääriäinen H, Pauli RM, van Essen T, Warman ML, Bonaventure J, Miny P, Ala-Kokko L. Autosomal recessive disorder otospondylomegaepiphyseal dysplasia is associated with loss-of-function mutations in the COL11A2 gene. Am J Hum Genet. 2000 Feb; 66(2):368-77. PMID: 10677296; PMCID: PMC1288089.
    Citations: 25     Fields:    Translation:HumansCells
  135. Marcelino J, Carpten JD, Suwairi WM, Gutierrez OM, Schwartz S, Robbins C, Sood R, Makalowska I, Baxevanis A, Johnstone B, Laxer RM, Zemel L, Kim CA, Herd JK, Ihle J, Williams C, Johnson M, Raman V, Alonso LG, Brunoni D, Gerstein A, Papadopoulos N, Bahabri SA, Trent JM, Warman ML. CACP, encoding a secreted proteoglycan, is mutated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Nat Genet. 1999 Nov; 23(3):319-22. PMID: 10545950.
    Citations: 108     Fields:    Translation:HumansAnimalsCells
  136. Annunen S, Körkkö J, Czarny M, Warman ML, Brunner HG, Kääriäinen H, Mulliken JB, Tranebjaerg L, Brooks DG, Cox GF, Cruysberg JR, Curtis MA, Davenport SL, Friedrich CA, Kaitila I, Krawczynski MR, Latos-Bielenska A, Mukai S, Olsen BR, Shinno N, Somer M, Vikkula M, Zlotogora J, Prockop DJ, Ala-Kokko L. Splicing mutations of 54-bp exons in the COL11A1 gene cause Marshall syndrome, but other mutations cause overlapping Marshall/Stickler phenotypes. Am J Hum Genet. 1999 Oct; 65(4):974-83. PMID: 10486316; PMCID: PMC1288268.
    Citations: 68     Fields:    Translation:HumansCells
  137. Gong Y, Wei J, Shao C, Guo Y, Chen B, Guo C, Warman M. [Mapping the gene responsible for Smith-Fineman-Myers syndrome to Xq25]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 1999 Oct; 16(5):277-80. PMID: 10514530.
    Citations: 1     Fields:    Translation:HumansCells
  138. Hurvitz JR, Suwairi WM, Van Hul W, El-Shanti H, Superti-Furga A, Roudier J, Holderbaum D, Pauli RM, Herd JK, Van Hul EV, Rezai-Delui H, Legius E, Le Merrer M, Al-Alami J, Bahabri SA, Warman ML. Mutations in the CCN gene family member WISP3 cause progressive pseudorheumatoid dysplasia. Nat Genet. 1999 Sep; 23(1):94-8. PMID: 10471507.
    Citations: 85     Fields:    Translation:HumansCells
  139. Paassilta P, Pihlajamaa T, Annunen S, Brewton RG, Wood BM, Johnson CC, Liu J, Gong Y, Warman ML, Prockop DJ, Mayne R, Ala-Kokko L. Complete sequence of the 23-kilobase human COL9A3 gene. Detection of Gly-X-Y triplet deletions that represent neutral variants. J Biol Chem. 1999 Aug 06; 274(32):22469-75. PMID: 10428822.
    Citations: 9     Fields:    Translation:HumansCells
  140. Robin NH, Hurvitz J, Warman ML, Morrison S. Clinical and molecular studies of brachydactyly type D. Am J Med Genet. 1999 Aug 06; 85(4):413-8. PMID: 10398270.
    Citations: 1     Fields:    Translation:Humans
  141. Boon LM, Brouillard P, Irrthum A, Karttunen L, Warman ML, Rudolph R, Mulliken JB, Olsen BR, Vikkula M. A gene for inherited cutaneous venous anomalies ("glomangiomas") localizes to chromosome 1p21-22. Am J Hum Genet. 1999 Jul; 65(1):125-33. PMID: 10364524; PMCID: PMC1378082.
    Citations: 28     Fields:    Translation:HumansCells
  142. Gong Y, Krakow D, Marcelino J, Wilkin D, Chitayat D, Babul-Hirji R, Hudgins L, Cremers CW, Cremers FP, Brunner HG, Reinker K, Rimoin DL, Cohn DH, Goodman FR, Reardon W, Patton M, Francomano CA, Warman ML. Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis. Nat Genet. 1999 Mar; 21(3):302-4. PMID: 10080184.
    Citations: 68     Fields:    Translation:HumansAnimals
  143. Gong Y, Chitayat D, Kerr B, Chen T, Babul-Hirji R, Pal A, Reiss M, Warman ML. Brachydactyly type B: clinical description, genetic mapping to chromosome 9q, and evidence for a shared ancestral mutation. Am J Hum Genet. 1999 Feb; 64(2):570-7. PMID: 9973295; PMCID: PMC1377767.
    Citations: 5     Fields:    Translation:HumansCells
  144. Kurima K, Warman ML, Krishnan S, Domowicz M, Krueger RC, Deyrup A, Schwartz NB. A member of a family of sulfate-activating enzymes causes murine brachymorphism. Proc Natl Acad Sci U S A. 1998 Jul 21; 95(15):8681-5. PMID: 9671738; PMCID: PMC21136.
    Citations: 36     Fields:    Translation:AnimalsCells
  145. Kant SG, Polinkovsky A, Mundlos S, Zabel B, Thomeer RT, Zonderland HM, Shih L, van Haeringen A, Warman ML. Acromesomelic dysplasia Maroteaux type maps to human chromosome 9. Am J Hum Genet. 1998 Jul; 63(1):155-62. PMID: 9634515; PMCID: PMC1377238.
    Citations: 12     Fields:    Translation:HumansCells
  146. Griffith AJ, Sprunger LK, Sirko-Osadsa DA, Tiller GE, Meisler MH, Warman ML. Marshall syndrome associated with a splicing defect at the COL11A1 locus. Am J Hum Genet. 1998 Apr; 62(4):816-23. PMID: 9529347; PMCID: PMC1377029.
    Citations: 31     Fields:    Translation:HumansCells
  147. Meisler MH, Griffith AJ, Warman M, Tiller G, Sprunger LK. Gene symbol: COL11A1. Disease: Marshall syndrome. Hum Genet. 1998 Apr; 102(4):498. PMID: 9600252.
    Citations: 1     Fields:    Translation:HumansCells
  148. Bahabri SA, Suwairi WM, Laxer RM, Polinkovsky A, Dalaan AA, Warman ML. The camptodactyly-arthropathy-coxa vara-pericarditis syndrome: clinical features and genetic mapping to human chromosome 1. Arthritis Rheum. 1998 Apr; 41(4):730-5. PMID: 9550484.
    Citations: 33     Fields:    Translation:HumansCells
  149. Sirko-Osadsa DA, Murray MA, Scott JA, Lavery MA, Warman ML, Robin NH. Stickler syndrome without eye involvement is caused by mutations in COL11A2, the gene encoding the alpha2(XI) chain of type XI collagen. J Pediatr. 1998 Feb; 132(2):368-71. PMID: 9506662.
    Citations: 33     Fields:    Translation:Humans
  150. Tiller GE, Warman ML, Gong Y, Knoll JH, Mayne R, Brewton RG. Physical and linkage mapping of the gene for the alpha3 chain of type IX collagen, COL9A3, to human chromosome 20q13.3. Cytogenet Cell Genet. 1998; 81(3-4):205-7. PMID: 9730604.
    Citations:    Fields:    Translation:HumansCells
  151. Polinkovsky A, Robin NH, Thomas JT, Irons M, Lynn A, Goodman FR, Reardon W, Kant SG, Brunner HG, van der Burgt I, Chitayat D, McGaughran J, Donnai D, Luyten FP, Warman ML. Mutations in CDMP1 cause autosomal dominant brachydactyly type C. Nat Genet. 1997 Sep; 17(1):18-9. PMID: 9288091.
    Citations: 69     Fields:    Translation:HumansCells
  152. Cheung DS, Warman ML, Mulliken JB. Hemangioma in twins. Ann Plast Surg. 1997 Mar; 38(3):269-74. PMID: 9088466.
    Citations: 10     Fields:    Translation:Humans
  153. Robin NH, Gunay-Aygun M, Polinkovsky A, Warman ML, Morrison S. Clinical and locus heterogeneity in brachydactyly type C. Am J Med Genet. 1997 Jan 31; 68(3):369-77. PMID: 9024575.
    Citations: 3     Fields:    Translation:HumansCells
  154. Vikkula M, Boon LM, Carraway KL, Calvert JT, Diamonti AJ, Goumnerov B, Pasyk KA, Marchuk DA, Warman ML, Cantley LC, Mulliken JB, Olsen BR. Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2. Cell. 1996 Dec 27; 87(7):1181-90. PMID: 8980225.
    Citations: 166     Fields:    Translation:HumansCells
  155. Gong Y, Vikkula M, Boon L, Liu J, Beighton P, Ramesar R, Peltonen L, Somer H, Hirose T, Dallapiccola B, De Paepe A, Swoboda W, Zabel B, Superti-Furga A, Steinmann B, Brunner HG, Jans A, Boles RG, Adkins W, van den Boogaard MJ, Olsen BR, Warman ML. Osteoporosis-pseudoglioma syndrome, a disorder affecting skeletal strength and vision, is assigned to chromosome region 11q12-13. Am J Hum Genet. 1996 Jul; 59(1):146-51. PMID: 8659519; PMCID: PMC1915094.
    Citations: 55     Fields:    Translation:HumansCells
  156. Muragaki Y, Mariman EC, van Beersum SE, Perälä M, van Mourik JB, Warman ML, Hamel BC, Olsen BR. A mutation in COL9A2 causes multiple epiphyseal dysplasia (EDM2). Ann N Y Acad Sci. 1996 Jun 08; 785:303-6. PMID: 8702162.
    Citations: 3     Fields:    Translation:HumansCells
  157. Mulliken JB, Warman ML. Molecular genetics and craniofacial surgery. Plast Reconstr Surg. 1996 Mar; 97(3):666-75. PMID: 8596804.
    Citations: 1     Fields:    Translation:HumansCells
  158. Muragaki Y, Mariman EC, van Beersum SE, Perälä M, van Mourik JB, Warman ML, Olsen BR, Hamel BC. A mutation in the gene encoding the alpha 2 chain of the fibril-associated collagen IX, COL9A2, causes multiple epiphyseal dysplasia (EDM2). Nat Genet. 1996 Jan; 12(1):103-5. PMID: 8528240.
    Citations: 40     Fields:    Translation:HumansCells
  159. Brewton RG, Wood BM, Ren ZX, Gong Y, Tiller GE, Warman ML, Lee B, Horton WA, Olsen BR, Baker JR, et al. Molecular cloning of the alpha 3 chain of human type IX collagen: linkage of the gene COL9A3 to chromosome 20q13.3. Genomics. 1995 Nov 20; 30(2):329-36. PMID: 8586434.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  160. North KN, Korson MS, Gopal YR, Rohr FJ, Brazelton TB, Waisbren SE, Warman ML. Neonatal-onset propionic acidemia: neurologic and developmental profiles, and implications for management. J Pediatr. 1995 Jun; 126(6):916-22. PMID: 7539836.
    Citations: 18     Fields:    Translation:Humans
  161. Gallione CJ, Pasyk KA, Boon LM, Lennon F, Johnson DW, Helmbold EA, Markel DS, Vikkula M, Mulliken JB, Warman ML, et al. A gene for familial venous malformations maps to chromosome 9p in a second large kindred. J Med Genet. 1995 Mar; 32(3):197-9. PMID: 7783168; PMCID: PMC1050316.
    Citations: 28     Fields:    Translation:HumansCells
  162. Li Y, Lacerda DA, Warman ML, Beier DR, Yoshioka H, Ninomiya Y, Oxford JT, Morris NP, Andrikopoulos K, Ramirez F, et al. A fibrillar collagen gene, Col11a1, is essential for skeletal morphogenesis. Cell. 1995 Feb 10; 80(3):423-30. PMID: 7859283.
    Citations: 108     Fields:    Translation:AnimalsCells
  163. Mundlos S, Mulliken JB, Abramson DL, Warman ML, Knoll JH, Olsen BR. Genetic mapping of cleidocranial dysplasia and evidence of a microdeletion in one family. Hum Mol Genet. 1995 Jan; 4(1):71-5. PMID: 7711736.
    Citations: 32     Fields:    Translation:HumansCells
  164. Briggs MD, Choi H, Warman ML, Loughlin JA, Wordsworth P, Sykes BC, Irven CM, Smith M, Wynne-Davies R, Lipson MH, et al. Genetic mapping of a locus for multiple epiphyseal dysplasia (EDM2) to a region of chromosome 1 containing a type IX collagen gene. Am J Hum Genet. 1994 Oct; 55(4):678-84. PMID: 7942845; PMCID: PMC1918298.
    Citations: 16     Fields:    Translation:HumansCells