Harvard Catalyst Profiles

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Ula V. Jurkunas, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R13EY028423 (JURKUNAS, ULA V.) Sep 1, 2017 - Aug 31, 2018
    NIH/NEI
    30th Biennial Cornea Conference
    Role: Principal Investigator
  2. UG1EY026508 (JURKUNAS, ULA V.) Jul 1, 2017 - Jun 30, 2021
    NIH/NEI
    Safety and Feasibility of Cultivated Autologous Limbal Epithelial Cell (CALEC) Transplantation in the Treatment of Limbal Stem Cell Deficiency
    Role: Principal Investigator
  3. R01EY020581 (JURKUNAS, ULA V.) Jul 1, 2010 - Jul 31, 2020
    NIH/NEI
    Role of Oxidative Stress in Pathogenesis of Fuchs Endothelial Corneal Dystrophy
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Jurkunas UV. Fuchs Endothelial Corneal Dystrophy Through the Prism of Oxidative Stress. Cornea. 2018 Nov; 37 Suppl 1:S50-S54. PMID: 30299369.
    Citations:    Fields:    Translation:HumansCells
  2. Aggarwal S, Cavalcanti BM, Regali L, Cruzat A, Trinidad M, Williams C, Jurkunas UV, Hamrah P. In Vivo Confocal Microscopy Shows Alterations in Nerve Density and Dendritiform Cell Density in Fuchs' Endothelial Corneal Dystrophy. Am J Ophthalmol. 2018 Dec; 196:136-144. PMID: 30194928.
    Citations:    Fields:    
  3. Satitpitakul V, Sun Z, Suri K, Amouzegar A, Katikireddy KR, Jurkunas UV, Kheirkhah A, Dana R. Vasoactive Intestinal Peptide Promotes Corneal Allograft Survival. Am J Pathol. 2018 Sep; 188(9):2016-2024. PMID: 30097165.
    Citations:    Fields:    
  4. Kocaba V, Katikireddy KR, Gipson I, Price MO, Price FW, Jurkunas UV. Association of the Gutta-Induced Microenvironment With Corneal Endothelial Cell Behavior and Demise in Fuchs Endothelial Corneal Dystrophy. JAMA Ophthalmol. 2018 Aug 01; 136(8):886-892. PMID: 29852040.
    Citations:    Fields:    
  5. Eghrari AO, Vasanth S, Gapsis BC, Bison H, Jurkunas U, Riazuddin SA, Gottsch JD. Identification of a Novel TCF4 Isoform in the Human Corneal Endothelium. Cornea. 2018 Jul; 37(7):899-903. PMID: 29677003.
    Citations:    Fields:    Translation:HumansCells
  6. Vavvas DG, Dryja TP, Wilson ME, Olsen TW, Shah A, Jurkunas U, Pineda R, Poulaki V, Palioura S, Veldman P, Moreno-Montañés J, Pinazo-Duran MD, Pastor JC, Tsilimbaris M, Rhee D, Colby K, Hunter DG, Thanos S, Sakamoto T, Pasquale LR, Miller JW, VanderVeen D, Lambert SR. Lens regeneration in children. Nature. 2018 04 04; 556(7699):E2-E3. PMID: 29620729.
    Citations: 1     Fields:    
  7. Davies E, Jurkunas U, Pineda R. Predictive Factors for Corneal Clearance After Descemetorhexis Without Endothelial Keratoplasty. Cornea. 2018 Feb; 37(2):137-140. PMID: 29053562.
    Citations: 1     Fields:    Translation:Humans
  8. Charles NC, Jakobiec FA, Zakka FR, Haberman ID, Katikireddy KR, Jurkunas UV. Limbal Cysts: A Subset Exhibiting Cornea-Specific Cytokeratins. Ophthalmic Plast Reconstr Surg. 2018 Jan/Feb; 34(1):e29-e31. PMID: 28926502.
    Citations:    Translation:Humans
  9. Katikireddy KR, White TL, Miyajima T, Vasanth S, Raoof D, Chen Y, Price MO, Price FW, Jurkunas UV. NQO1 downregulation potentiates menadione-induced endothelial-mesenchymal transition during rosette formation in Fuchs endothelial corneal dystrophy. Free Radic Biol Med. 2018 02 20; 116:19-30. PMID: 29294389.
    Citations: 2     Fields:    
  10. Yin J, Jurkunas U. Limbal Stem Cell Transplantation and Complications. Semin Ophthalmol. 2018; 33(1):134-141. PMID: 29172876.
    Citations:    Fields:    Translation:HumansCells
  11. Gupta R, Kinderyte R, Jacobs DS, Jurkunas UV. Elimination of Anterior Corneal Steepening With Descemet Membrane Endothelial Keratoplasty in a Patient With Fuchs Dystrophy and Keratoconus: Implications for IOL Calculation. Cornea. 2017 Oct; 36(10):1260-1262. PMID: 28749896.
    Citations:    Fields:    Translation:Humans
  12. Syed ZA, Tran JA, Jurkunas UV. Peripheral Endothelial Cell Count Is a Predictor of Disease Severity in Advanced Fuchs Endothelial Corneal Dystrophy. Cornea. 2017 Oct; 36(10):1166-1171. PMID: 28731879.
    Citations:    Fields:    Translation:Humans
  13. Benischke AS, Vasanth S, Miyai T, Katikireddy KR, White T, Chen Y, Halilovic A, Price M, Price F, Liton PB, Jurkunas UV. Activation of mitophagy leads to decline in Mfn2 and loss of mitochondrial mass in Fuchs endothelial corneal dystrophy. Sci Rep. 2017 07 27; 7(1):6656. PMID: 28751712.
    Citations: 2     Fields:    
  14. Amparo F, Yin J, Di Zazzo A, Abud T, Jurkunas UV, Hamrah P, Dana R. Evaluating Changes in Ocular Redness Using a Novel Automated Method. Transl Vis Sci Technol. 2017 Jul; 6(4):13. PMID: 28736686.
    Citations:    
  15. Richarme G, Liu C, Mihoub M, Abdallah J, Leger T, Joly N, Liebart JC, Jurkunas UV, Nadal M, Bouloc P, Dairou J, Lamouri A. Guanine glycation repair by DJ-1/Park7 and its bacterial homologs. Science. 2017 Jul 14; 357(6347):208-211. PMID: 28596309.
    Citations: 7     Fields:    Translation:HumansCells
  16. Kim EC, Toyono T, Berlinicke CA, Zack DJ, Jurkunas U, Usui T, Jun AS. Screening and Characterization of Drugs That Protect Corneal Endothelial Cells Against Unfolded Protein Response and Oxidative Stress. Invest Ophthalmol Vis Sci. 2017 02 01; 58(2):892-900. PMID: 28159976.
    Citations: 4     Fields:    Translation:HumansCells
  17. Homer N, Jurkunas UV. The Use of Femtosecond Laser in Refractive and Cataract Surgery. Int Ophthalmol Clin. 2017; 57(4):1-10. PMID: 28885242.
    Citations:    Fields:    Translation:Humans
  18. Katikireddy KR, Schmedt T, Price MO, Price FW, Jurkunas UV. Existence of Neural Crest-Derived Progenitor Cells in Normal and Fuchs Endothelial Dystrophy Corneal Endothelium. Am J Pathol. 2016 10; 186(10):2736-50. PMID: 27639969.
    Citations: 2     Fields:    Translation:HumansCells
  19. Qazi Y, Hurwitz S, Khan S, Jurkunas UV, Dana R, Hamrah P. Validity and Reliability of a Novel Ocular Pain Assessment Survey (OPAS) in Quantifying and Monitoring Corneal and Ocular Surface Pain. Ophthalmology. 2016 07; 123(7):1458-68. PMID: 27089999.
    Citations: 3     Fields:    Translation:Humans
  20. Halilovic A, Schmedt T, Benischke AS, Hamill C, Chen Y, Santos JH, Jurkunas UV. Menadione-Induced DNA Damage Leads to Mitochondrial Dysfunction and Fragmentation During Rosette Formation in Fuchs Endothelial Corneal Dystrophy. Antioxid Redox Signal. 2016 06 20; 24(18):1072-83. PMID: 26935406.
    Citations: 3     Fields:    Translation:HumansCells
  21. Liu C, Vojnovic D, Kochevar IE, Jurkunas UV. UV-A Irradiation Activates Nrf2-Regulated Antioxidant Defense and Induces p53/Caspase3-Dependent Apoptosis in Corneal Endothelial Cells. Invest Ophthalmol Vis Sci. 2016 Apr 01; 57(4):2319-27. PMID: 27127932.
    Citations: 6     Fields:    Translation:HumansCells
  22. Katikireddy KR, Jurkunas UV. Limbal Stromal Tissue Specific Stem Cells and Their Differentiation Potential to Corneal Epithelial Cells. Methods Mol Biol. 2016; 1341:437-44. PMID: 25762299.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  23. Saboo US, Amparo F, Shikari H, Jurkunas UV, Dana R. Outcomes of phacoemulsification in patients with chronic ocular graft-versus-host disease. Graefes Arch Clin Exp Ophthalmol. 2015 Jun; 253(6):901-7. PMID: 25619668; PMCID: PMC4447562.
    Citations: 2     Fields:    Translation:Humans
  24. Chauhan SK, Jurkunas U, Funaki T, Dastjerdi M, Dana R. Quantification of allospecific and nonspecific corneal endothelial cell damage after corneal transplantation. Eye (Lond). 2015 Jan; 29(1):136-44. PMID: 25323855; PMCID: PMC4289838.
    Citations: 2     Fields:    Translation:AnimalsCells
  25. Liu C, Chen Y, Kochevar IE, Jurkunas UV. Decreased DJ-1 leads to impaired Nrf2-regulated antioxidant defense and increased UV-A-induced apoptosis in corneal endothelial cells. Invest Ophthalmol Vis Sci. 2014 Jul 31; 55(9):5551-60. PMID: 25082883.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  26. Katikireddy KR, Dana R, Jurkunas UV. Differentiation potential of limbal fibroblasts and bone marrow mesenchymal stem cells to corneal epithelial cells. Stem Cells. 2014 Mar; 32(3):717-29. PMID: 24022965.
    Citations: 15     Fields:    Translation:HumansCells
  27. Ziaei A, Schmedt T, Chen Y, Jurkunas UV. Sulforaphane decreases endothelial cell apoptosis in fuchs endothelial corneal dystrophy: a novel treatment. Invest Ophthalmol Vis Sci. 2013 Oct 15; 54(10):6724-34. PMID: 24030461; PMCID: PMC3797593.
    Citations: 7     Fields:    Translation:HumansCells
  28. Hamill CE, Schmedt T, Jurkunas U. Fuchs endothelial cornea dystrophy: a review of the genetics behind disease development. Semin Ophthalmol. 2013 Sep-Nov; 28(5-6):281-6. PMID: 24138036; PMCID: PMC3997056.
    Citations: 5     Fields:    Translation:Humans
  29. Amparo F, Dastjerdi MH, Okanobo A, Ferrari G, Smaga L, Hamrah P, Jurkunas U, Schaumberg DA, Dana R. Topical interleukin 1 receptor antagonist for treatment of dry eye disease: a randomized clinical trial. JAMA Ophthalmol. 2013 Jun; 131(6):715-723. PMID: 23599118; PMCID: PMC4167802.
    Citations: 22     Fields:    Translation:HumansCTClinical Trials
  30. Amparo F, Sadrai Z, Jin Y, Alfonso-Bartolozzi B, Wang H, Shikari H, Ciolino JB, Chodosh J, Jurkunas U, Schaumberg DA, Dana R. Safety and efficacy of the multitargeted receptor kinase inhibitor pazopanib in the treatment of corneal neovascularization. Invest Ophthalmol Vis Sci. 2013 Jan 17; 54(1):537-44. PMID: 23233252; PMCID: PMC3558296.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  31. Jašinskas V, Rudalevicius P, Miliauskas A, Milcius D, Jurkunas UV. Keratoprosthesis surgery as an alternative to keratoplasty. Medicina (Kaunas). 2013; 49(6):291-9. PMID: 24248010.
    Citations: 1     Fields:    Translation:Humans
  32. Schmedt T, Chen Y, Nguyen TT, Li S, Bonanno JA, Jurkunas UV. Telomerase immortalization of human corneal endothelial cells yields functional hexagonal monolayers. PLoS One. 2012; 7(12):e51427. PMID: 23284695.
    Citations: 17     Fields:    Translation:HumansCells
  33. Schrems-Hoesl LM, Schrems WA, Cruzat A, Shahatit BM, Bayhan HA, Jurkunas UV, Hamrah P. Cellular and subbasal nerve alterations in early stage Fuchs' endothelial corneal dystrophy: an in vivo confocal microscopy study. Eye (Lond). 2013 Jan; 27(1):42-9. PMID: 23154490; PMCID: PMC3545379.
    Citations: 8     Fields:    Translation:HumansCells
  34. Sharma SM, Fuchsluger T, Ahmad S, Katikireddy KR, Armant M, Dana R, Jurkunas UV. Comparative analysis of human-derived feeder layers with 3T3 fibroblasts for the ex vivo expansion of human limbal and oral epithelium. Stem Cell Rev. 2012 Sep; 8(3):696-705. PMID: 21964568.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  35. Bitar MS, Liu C, Ziaei A, Chen Y, Schmedt T, Jurkunas UV. Decline in DJ-1 and decreased nuclear translocation of Nrf2 in Fuchs endothelial corneal dystrophy. Invest Ophthalmol Vis Sci. 2012 Aug 24; 53(9):5806-13. PMID: 22836768; PMCID: PMC3428112.
    Citations: 16     Fields:    Translation:HumansCells
  36. Kopplin LJ, Przepyszny K, Schmotzer B, Rudo K, Babineau DC, Patel SV, Verdier DD, Jurkunas U, Iyengar SK, Lass JH. Relationship of Fuchs endothelial corneal dystrophy severity to central corneal thickness. Arch Ophthalmol. 2012 Apr; 130(4):433-9. PMID: 22491913; PMCID: PMC3859299.
    Citations: 17     Fields:    Translation:Humans
  37. Riazuddin SA, Parker DS, McGlumphy EJ, Oh EC, Iliff BW, Schmedt T, Jurkunas U, Schleif R, Katsanis N, Gottsch JD. Mutations in LOXHD1, a recessive-deafness locus, cause dominant late-onset Fuchs corneal dystrophy. Am J Hum Genet. 2012 Mar 09; 90(3):533-9. PMID: 22341973; PMCID: PMC3309196.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  38. Azizi B, Ziaei A, Fuchsluger T, Schmedt T, Chen Y, Jurkunas UV. p53-regulated increase in oxidative-stress--induced apoptosis in Fuchs endothelial corneal dystrophy: a native tissue model. Invest Ophthalmol Vis Sci. 2011 Dec 02; 52(13):9291-7. PMID: 22064994; PMCID: PMC3250096.
    Citations: 26     Fields:    Translation:HumansCells
  39. Schmedt T, Silva MM, Ziaei A, Jurkunas U. Molecular bases of corneal endothelial dystrophies. Exp Eye Res. 2012 Feb; 95(1):24-34. PMID: 21855542; PMCID: PMC3273549.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  40. Jurkunas UV, Jakobiec FA, Shin J, Zakka FR, Michaud N, Jethva R. Reversible corneal epitheliopathy caused by vitamin B12 and folate deficiency in a vegan with a genetic mutation: a new disease. Eye (Lond). 2011 Nov; 25(11):1512-4. PMID: 21818128; PMCID: PMC3213645.
    Citations:    Fields:    Translation:Humans
  41. Cruzat A, Witkin D, Baniasadi N, Zheng L, Ciolino JB, Jurkunas UV, Chodosh J, Pavan-Langston D, Dana R, Hamrah P. Inflammation and the nervous system: the connection in the cornea in patients with infectious keratitis. Invest Ophthalmol Vis Sci. 2011 Jul 11; 52(8):5136-43. PMID: 21460259; PMCID: PMC3176064.
    Citations: 45     Fields:    Translation:HumansCells
  42. Fuchsluger TA, Jurkunas U, Kazlauskas A, Dana R. [Viral vectors for gene delivery to corneal endothelial cells]. Klin Monbl Augenheilkd. 2011 Jun; 228(6):498-503. PMID: 21656431.
    Citations: 2     Fields:    Translation:HumansCells
  43. Fuchsluger TA, Jurkunas U, Kazlauskas A, Dana R. Anti-apoptotic gene therapy prolongs survival of corneal endothelial cells during storage. Gene Ther. 2011 Aug; 18(8):778-87. PMID: 21412281; PMCID: PMC3587653.
    Citations: 11     Fields:    Translation:HumansCells
  44. Fuchsluger TA, Jurkunas U, Kazlauskas A, Dana R. Corneal endothelial cells are protected from apoptosis by gene therapy. Hum Gene Ther. 2011 May; 22(5):549-58. PMID: 21158568; PMCID: PMC3081440.
    Citations: 8     Fields:    Translation:HumansCells
  45. Lam HY, Wiggs JL, Jurkunas UV. Unusual presentation of presumed posterior polymorphous dystrophy associated with iris heterochromia, band keratopathy, and keratoconus. Cornea. 2010 Oct; 29(10):1180-5. PMID: 20567203; PMCID: PMC2945457.
    Citations: 10     Fields:    Translation:Humans
  46. Elhalis H, Azizi B, Jurkunas UV. Fuchs endothelial corneal dystrophy. Ocul Surf. 2010 Oct; 8(4):173-84. PMID: 20964980.
    Citations: 32     Fields:    Translation:HumansAnimals
  47. Ahmad S, Osei-Bempong C, Dana R, Jurkunas U. The culture and transplantation of human limbal stem cells. J Cell Physiol. 2010 Oct; 225(1):15-9. PMID: 20506173.
    Citations: 18     Fields:    Translation:HumansCells
  48. Jurkunas UV, Bitar MS, Funaki T, Azizi B. Evidence of oxidative stress in the pathogenesis of fuchs endothelial corneal dystrophy. Am J Pathol. 2010 Nov; 177(5):2278-89. PMID: 20847286; PMCID: PMC2966787.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  49. Mandell KJ, Jurkunas UV, Pineda R. Intraocular lens calculations after corneal refractive surgery. Int Ophthalmol Clin. 2010; 50(1):181-9. PMID: 20057306.
    Citations:    Fields:    Translation:Humans
  50. Jurkunas U, Behlau I, Colby K. Fungal keratitis: changing pathogens and risk factors. Cornea. 2009 Jul; 28(6):638-43. PMID: 19512908.
    Citations: 22     Fields:    Translation:HumansAnimals
  51. Lim P, Fuchsluger TA, Jurkunas UV. Limbal stem cell deficiency and corneal neovascularization. Semin Ophthalmol. 2009 May-Jun; 24(3):139-48. PMID: 19437349.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  52. Dastjerdi MH, Al-Arfaj KM, Nallasamy N, Hamrah P, Jurkunas UV, Pineda R, Pavan-Langston D, Dana R. Topical bevacizumab in the treatment of corneal neovascularization: results of a prospective, open-label, noncomparative study. Arch Ophthalmol. 2009 Apr; 127(4):381-9. PMID: 19365012; PMCID: PMC2703579.
    Citations: 45     Fields:    Translation:HumansCTClinical Trials
  53. Jurkunas UV, Bitar M, Rawe I. Colocalization of increased transforming growth factor-beta-induced protein (TGFBIp) and Clusterin in Fuchs endothelial corneal dystrophy. Invest Ophthalmol Vis Sci. 2009 Mar; 50(3):1129-36. PMID: 19011008; PMCID: PMC2719557.
    Citations: 24     Fields:    Translation:Humans
  54. Jurkunas UV, Rawe I, Bitar MS, Zhu C, Harris DL, Colby K, Joyce NC. Decreased expression of peroxiredoxins in Fuchs' endothelial dystrophy. Invest Ophthalmol Vis Sci. 2008 Jul; 49(7):2956-63. PMID: 18378575; PMCID: PMC2773676.
    Citations: 31     Fields:    Translation:HumansCells
  55. Jurkunas UV, Bitar MS, Rawe I, Harris DL, Colby K, Joyce NC. Increased clusterin expression in Fuchs' endothelial dystrophy. Invest Ophthalmol Vis Sci. 2008 Jul; 49(7):2946-55. PMID: 18378577; PMCID: PMC2789477.
    Citations: 18     Fields:    Translation:HumansCells
  56. Harissi-Dagher M, Dana MR, Jurkunas UV. Keratoglobus in association with posterior polymorphous dystrophy. Cornea. 2007 Dec; 26(10):1288-91. PMID: 18043197.
    Citations: 2     Fields:    Translation:Humans
  57. Lee BW, Jurkunas UV, Harissi-Dagher M, Poothullil AM, Tobaigy FM, Azar DT. Ectatic disorders associated with a claw-shaped pattern on corneal topography. Am J Ophthalmol. 2007 Jul; 144(1):154-156. PMID: 17601448.
    Citations: 10     Fields:    Translation:Humans
  58. Jurkunas UV, Langston DP, Colby K. Use of voriconazole in the treatment of fungal keratitis. Int Ophthalmol Clin. 2007; 47(2):47-59. PMID: 17450006.
    Citations: 7     Fields:    Translation:Humans
  59. Jurkunas U, Azar DT. Potential complications of ocular surgery in patients with coexistent keratoconus and Fuchs' endothelial dystrophy. Ophthalmology. 2006 Dec; 113(12):2187-97. PMID: 16996603.
    Citations: 4     Fields:    Translation:Humans
  60. Yu EN, Jurkunas U, Rubin PA, Baltatzis S, Foster CS. Obliterative microangiopathy presenting as chronic conjunctivitis in a patient with relapsing polychondritis. Cornea. 2006 Jun; 25(5):621-2. PMID: 16783155.
    Citations: 3     Fields:    Translation:Humans
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.