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Melin Janardan Khandekar, M.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Tahir I, Marquardt JP, Mercaldo ND, Bourgouin PP, Wrobel MM, Mrah S, Sharp GC, Khandekar MJ, Willers H, Keane FK, Fintelmann FJ. Utility of Noncancerous Chest CT Features for Predicting Overall Survival and Noncancer Death in Patients With Stage I Lung Cancer Treated With Stereotactic Body Radiotherapy. AJR Am J Roentgenol. 2022 Oct; 219(4):579-589. PMID: 35416054.
    Citations:    Fields:    
  2. Milligan MG, Lennes IT, Hawari S, Khandekar MJ, Colson Y, Shepard JO, Frank A, Sequist LV, Willers H, Keane FK. Incidence of Radiation Therapy Among Patients Enrolled in a Multidisciplinary Pulmonary Nodule and Lung Cancer Screening Clinic. JAMA Netw Open. 2022 03 01; 5(3):e224840. PMID: 35357454; PMCID: PMC8972030.
    Citations:    Fields:    Translation:Humans
  3. Mendoza DP, Petranovic M, Som A, Wu MY, Park EY, Zhang EW, Archer JM, McDermott S, Khandekar M, Lanuti M, Gainor JF, Lennes IT, Shepard JO, Digumarthy SR. Lung-RADS Category 3 and 4 Nodules on Lung Cancer Screening in Clinical Practice. AJR Am J Roentgenol. 2022 07; 219(1):55-65. PMID: 35080453.
    Citations:    Fields:    Translation:Humans
  4. Subudhi S, Voutouri C, Hardin CC, Nikmaneshi MR, Patel AB, Verma A, Khandekar MJ, Dutta S, Stylianopoulos T, Jain RK, Munn LL. Strategies to minimize heterogeneity and optimize clinical trials in Acute Respiratory Distress Syndrome (ARDS): Insights from mathematical modelling. EBioMedicine. 2022 Jan; 75:103809. PMID: 35033853; PMCID: PMC8757652.
    Citations:    Fields:    Translation:HumansCells
  5. Bowes CL, Naranbhai V, St Denis KJ, Lam EC, Bertaux B, Keane FK, Khandekar MJ, Balazs AB, Iafrate JA, Gainor JF, Willers H. Heterogeneous immunogenicity of SARS-CoV-2 vaccines in cancer patients receiving radiotherapy. Radiother Oncol. 2022 01; 166:88-91. PMID: 34838892; PMCID: PMC8613981.
    Citations:    Fields:    Translation:HumansCells
  6. Khandekar MJ, Keane FK. Radiation Dose and Fractionation in Locally Advanced Lung Cancer: A Simple Question With a Complicated Answer. JAMA Oncol. 2021 10 01; 7(10):1505-1506. PMID: 34383023.
    Citations:    Fields:    Translation:Humans
  7. Xie Y, Kang K, Wang Y, Khandekar MJ, Willers H, Keane FK, Bortfeld TR. Automated clinical target volume delineation using deep 3D neural networks in radiation therapy of Non-small Cell Lung Cancer. Phys Imaging Radiat Oncol. 2021 Jul; 19:131-137. PMID: 34485718; PMCID: PMC8397906.
    Citations:    
  8. Wo JY, Clark JW, Eyler CE, Mino-Kenudson M, Klempner SJ, Allen JN, Keane FK, Parikh AR, Roeland E, Drapek LC, Ryan DP, Corcoran RB, Van Seventer E, Fetter IJ, Shahzade HA, Khandekar MJ, Lanuti M, Morse CR, Heist RS, Ulysse CA, Christopher B, Baglini C, Yeap BY, Mullen JT, Hong TS. Results and Molecular Correlates from a Pilot Study of Neoadjuvant Induction FOLFIRINOX Followed by Chemoradiation and Surgery for Gastroesophageal Adenocarcinomas. Clin Cancer Res. 2021 12 01; 27(23):6343-6353. PMID: 34330715.
    Citations: 1     Fields:    Translation:Humans
  9. Kamran SC, Yeap BY, Ulysse CA, Cronin C, Bowes CL, Durgin B, Gainor JF, Khandekar MJ, Tansky JY, Keane FK, Olsen CC, Willers H. Assessment of a Contralateral Esophagus-Sparing Technique in Locally Advanced Lung Cancer Treated With High-Dose Chemoradiation: A Phase 1 Nonrandomized Clinical Trial. JAMA Oncol. 2021 Jun 01; 7(6):910-914. PMID: 33830168; PMCID: PMC8033505.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  10. Subudhi S, Verma A, Patel AB, Hardin CC, Khandekar MJ, Lee H, McEvoy D, Stylianopoulos T, Munn LL, Dutta S, Jain RK. Comparing machine learning algorithms for predicting ICU admission and mortality in COVID-19. NPJ Digit Med. 2021 May 21; 4(1):87. PMID: 34021235; PMCID: PMC8140139.
    Citations: 21     
  11. Munn LL, Stylianopoulos T, Jain NK, Hardin CC, Khandekar MJ, Jain RK. Vascular Normalization to Improve Treatment of COVID-19: Lessons from Treatment of Cancer. Clin Cancer Res. 2021 05 15; 27(10):2706-2711. PMID: 33648989; PMCID: PMC8127351.
    Citations:    Fields:    Translation:HumansCellsPHPublic Health
  12. Voutouri C, Nikmaneshi MR, Hardin CC, Patel AB, Verma A, Khandekar MJ, Dutta S, Stylianopoulos T, Munn LL, Jain RK. In silico dynamics of COVID-19 phenotypes for optimizing clinical management. Proc Natl Acad Sci U S A. 2021 01 19; 118(3). PMID: 33402434.
    Citations: 15     Fields:    Translation:HumansCells
  13. Keane FK, Driscoll E, Bowes C, Durgin B, Khandekar MJ, Willers H. Low Rates of Chest Wall Toxicity When Individualizing the Planning Target Volume Margin in Patients With Early Stage Lung Cancer Treated With Stereotactic Body Radiation Therapy. Pract Radiat Oncol. 2021 May-Jun; 11(3):e282-e291. PMID: 33239160.
    Citations: 1     Fields:    Translation:Humans
  14. Voutouri C, Nikmaneshi MR, Hardin CC, Patel AB, Verma A, Khandekar MJ, Dutta S, Stylianopoulos T, Munn LL, Jain RK. In silico dynamics of COVID-19 phenotypes for optimizing clinical management. Res Sq. 2020 Sep 03. PMID: 32908974.
    Citations:    
  15. Lebow ES, Hwang WL, Zieminski S, Wang Y, Niemierko A, Mehan WA, Oh KS, Khandekar M, Willers H, Shih HA. Early experience with hippocampal avoidance whole brain radiation therapy and simultaneous integrated boost for brain metastases. J Neurooncol. 2020 May; 148(1):81-88. PMID: 32307637.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  16. Li Y, Dykstra M, Best TD, Pursley J, Chopra N, Keane FK, Khandekar MJ, Sharp GC, Paganetti H, Willers H, Fintelmann FJ, Grassberger C. Differential inflammatory response dynamics in normal lung following stereotactic body radiation therapy with protons versus photons. Radiother Oncol. 2019 07; 136:169-175. PMID: 31015121.
    Citations: 6     Fields:    Translation:Humans
  17. Khandekar MJ, Piotrowska Z, Willers H, Sequist LV. Role of Epidermal Growth Factor Receptor (EGFR) Inhibitors and Radiation in the Management of Brain Metastases from EGFR Mutant Lung Cancers. Oncologist. 2018 09; 23(9):1054-1062. PMID: 29703765.
    Citations: 5     Fields:    Translation:Humans
  18. Zieminski S, Khandekar M, Wang Y. Assessment of multi-criteria optimization (MCO) for volumetric modulated arc therapy (VMAT) in hippocampal avoidance whole brain radiation therapy (HA-WBRT). J Appl Clin Med Phys. 2018 Mar; 19(2):184-190. PMID: 29411526.
    Citations: 5     Fields:    Translation:Humans
  19. Khandekar MJ, Jain R. Smooth sailing for immunotherapy for unresectable stage III non-small cell lung cancer: the PACIFIC study. Transl Cancer Res. 2018 Feb; 7(Suppl 1):S16-S20. PMID: 30175050; PMCID: PMC6117158.
    Citations: 4     
  20. Khandekar MJ, Banks AS, Laznik-Bogoslavski D, White JP, Choi JH, Kazak L, Lo JC, Cohen P, Wong KK, Kamenecka TM, Griffin PR, Spiegelman BM. Noncanonical agonist PPAR? ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy. Proc Natl Acad Sci U S A. 2018 01 16; 115(3):561-566. PMID: 29295932; PMCID: PMC5776997.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  21. Campo M, Al-Halabi H, Khandekar M, Shaw AT, Sequist LV, Willers H. Integration of Stereotactic Body Radiation Therapy With Tyrosine Kinase Inhibitors in Stage IV Oncogene-Driven Lung Cancer. Oncologist. 2016 08; 21(8):964-73. PMID: 27354669.
    Citations: 23     Fields:    Translation:Humans
  22. Lo JC, Ljubicic S, Leibiger B, Kern M, Leibiger IB, Moede T, Kelly ME, Chatterjee Bhowmick D, Murano I, Cohen P, Banks AS, Khandekar MJ, Dietrich A, Flier JS, Cinti S, Blüher M, Danial NN, Berggren PO, Spiegelman BM. Adipsin is an adipokine that improves ß cell function in diabetes. Cell. 2014 Jul 03; 158(1):41-53. PMID: 24995977.
    Citations: 128     Fields:    Translation:HumansAnimalsCells
  23. Cohen P, Levy JD, Zhang Y, Frontini A, Kolodin DP, Svensson KJ, Lo JC, Zeng X, Ye L, Khandekar MJ, Wu J, Gunawardana SC, Banks AS, Camporez JP, Jurczak MJ, Kajimura S, Piston DW, Mathis D, Cinti S, Shulman GI, Seale P, Spiegelman BM. Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell. 2014 Jan 16; 156(1-2):304-16. PMID: 24439384.
    Citations: 388     Fields:    Translation:AnimalsCells
  24. Ye L, Wu J, Cohen P, Kazak L, Khandekar MJ, Jedrychowski MP, Zeng X, Gygi SP, Spiegelman BM. Fat cells directly sense temperature to activate thermogenesis. Proc Natl Acad Sci U S A. 2013 Jul 23; 110(30):12480-5. PMID: 23818608.
    Citations: 109     Fields:    Translation:AnimalsCells
  25. Khandekar MJ, Raut CP, Hornick JL, Wang Q, Alexander BM, Baldini EH. Paratesticular liposarcoma: unusual patterns of recurrence and importance of margins. Ann Surg Oncol. 2013 Jul; 20(7):2148-55. PMID: 23591942.
    Citations: 6     Fields:    Translation:Humans
  26. Ye L, Kleiner S, Wu J, Sah R, Gupta RK, Banks AS, Cohen P, Khandekar MJ, Boström P, Mepani RJ, Laznik D, Kamenecka TM, Song X, Liedtke W, Mootha VK, Puigserver P, Griffin PR, Clapham DE, Spiegelman BM. TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell. 2012 Sep 28; 151(1):96-110. PMID: 23021218.
    Citations: 149     Fields:    Translation:AnimalsCells
  27. Wu J, Boström P, Sparks LM, Ye L, Choi JH, Giang AH, Khandekar M, Virtanen KA, Nuutila P, Schaart G, Huang K, Tu H, van Marken Lichtenbelt WD, Hoeks J, Enerbäck S, Schrauwen P, Spiegelman BM. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell. 2012 Jul 20; 150(2):366-76. PMID: 22796012; PMCID: PMC3402601.
    Citations: 1323     Fields:    Translation:HumansAnimalsCells
  28. Gupta RK, Mepani RJ, Kleiner S, Lo JC, Khandekar MJ, Cohen P, Frontini A, Bhowmick DC, Ye L, Cinti S, Spiegelman BM. Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells. Cell Metab. 2012 Feb 08; 15(2):230-9. PMID: 22326224.
    Citations: 190     Fields:    Translation:AnimalsCells
  29. Khandekar MJ, Cohen P, Spiegelman BM. Molecular mechanisms of cancer development in obesity. Nat Rev Cancer. 2011 11 24; 11(12):886-95. PMID: 22113164.
    Citations: 353     Fields:    Translation:HumansAnimalsCells
  30. Truong MT, Nadgir RN, Hirsch AE, Subramaniam RM, Wang JW, Wu R, Khandekar M, Nawaz AO, Sakai O. Brachial plexus contouring with CT and MR imaging in radiation therapy planning for head and neck cancer. Radiographics. 2010 Jul-Aug; 30(4):1095-103. PMID: 20631370.
    Citations: 15     Fields:    Translation:Humans
  31. Julia S. Wong, Melin J. Khandekar. Challenges and Considerations in the Management of Ductal Carcinoma In Situ. 2008.
  32. Hoshino T, Shimizu R, Ohmori S, Nagano M, Pan X, Ohneda O, Khandekar M, Yamamoto M, Lim KC, Engel JD. Reduced BMP4 abundance in Gata2 hypomorphic mutant mice result in uropathies resembling human CAKUT. Genes Cells. 2008 Feb; 13(2):159-70. PMID: 18233958.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  33. Brandt W, Khandekar M, Suzuki N, Yamamoto M, Lim KC, Engel JD. Defining the functional boundaries of the Gata2 locus by rescue with a linked bacterial artificial chromosome transgene. J Biol Chem. 2008 Apr 04; 283(14):8976-83. PMID: 18211891.
    Citations: 9     Fields:    Translation:AnimalsCells
  34. Khandekar M, Brandt W, Zhou Y, Dagenais S, Glover TW, Suzuki N, Shimizu R, Yamamoto M, Lim KC, Engel JD. A Gata2 intronic enhancer confers its pan-endothelia-specific regulation. Development. 2007 May; 134(9):1703-12. PMID: 17395646.
    Citations: 52     Fields:    Translation:AnimalsCells
  35. Khandekar J, Khandekar M. Phase 1 clinical trials: not just for safety anymore? Arch Intern Med. 2006 Jul 24; 166(14):1440-1. PMID: 16864752.
    Citations: 2     Fields:    Translation:Humans
  36. Khandekar M. Function and regulation of transcription factor Gata2. 2006.
  37. Khandekar M, Suzuki N, Lewton J, Yamamoto M, Engel JD. Multiple, distant Gata2 enhancers specify temporally and tissue-specific patterning in the developing urogenital system. Mol Cell Biol. 2004 Dec; 24(23):10263-76. PMID: 15542836; PMCID: PMC529040.
    Citations: 30     Fields:    Translation:AnimalsCells
  38. Khandekar M., Zhou Y., Lim K.C., Engel J.D. Identification of a Gata2 urogenital enhancer in BAC transgenic mice. Poster Presentation. 2003.
  39. Khandekar M., Zhou Y., Lim K.C., Engel J.D. A BAC transgenic approach to identifying a Gata2 urogenital enhancer. Oral Presentation. 2002.
  40. Gaudry C.A., Palka H.L., Dusek R.L., Huen A.C., Khandekar M.J., Hudson L.G., Green K.J. Tyrosine phosphorylated plakoglobin is associated with desmogleins but not desmoplakin after epidermal growth factor receptor activation. Journal of Biological Chemistry. 2001; 276(27):24871-24880.
  41. Gaudry CA, Palka HL, Dusek RL, Huen AC, Khandekar MJ, Hudson LG, Green KJ. Tyrosine-phosphorylated plakoglobin is associated with desmogleins but not desmoplakin after epidermal growth factor receptor activation. J Biol Chem. 2001 Jul 06; 276(27):24871-80. PMID: 11335725.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  42. Khandekar M., Zhou Y., Engel J.D. Function and regulation of Gata2 in vascular development. Poster Presentation. 2001.
  43. Khandekar M., Pennacchio L., Myers R.M. Characterization of the distribution of Cystatin B in the brain of M. Musculus. Poster presentation. 1998.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.