Harvard Catalyst Profiles

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Melin Janardan Khandekar, M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Khandekar MJ, Keane FK. Radiation Dose and Fractionation in Locally Advanced Lung Cancer: A Simple Question With a Complicated Answer. JAMA Oncol. 2021 Aug 12. PMID: 34383023.
    Citations:    Fields:    
  2. Wo JY, Clark JW, Eyler CE, Mino-Kenudson M, Klempner SJ, Allen JN, Keane FK, Parikh AR, Roeland E, Drapek LC, Ryan DP, Corcoran RB, Van Seventer E, Fetter IJ, Shahzade HA, Khandekar MJ, Lanuti M, Morse CR, Heist RS, Ulysse CA, Christopher B, Baglini C, Yeap BY, Mullen JT, Hong TS. Results and molecular correlates from a pilot study of neoadjuvant induction FOLFIRINOX followed by chemoradiation and surgery for gastroesophageal adenocarcinomas. Clin Cancer Res. 2021 Jul 30. PMID: 34330715.
    Citations:    Fields:    
  3. Kamran SC, Yeap BY, Ulysse CA, Cronin C, Bowes CL, Durgin B, Gainor JF, Khandekar MJ, Tansky JY, Keane FK, Olsen CC, Willers H. Assessment of a Contralateral Esophagus-Sparing Technique in Locally Advanced Lung Cancer Treated With High-Dose Chemoradiation: A Phase 1 Nonrandomized Clinical Trial. JAMA Oncol. 2021 Jun 01; 7(6):910-914. PMID: 33830168.
    Citations:    Fields:    
  4. Subudhi S, Verma A, Patel AB, Hardin CC, Khandekar MJ, Lee H, McEvoy D, Stylianopoulos T, Munn LL, Dutta S, Jain RK. Comparing machine learning algorithms for predicting ICU admission and mortality in COVID-19. NPJ Digit Med. 2021 May 21; 4(1):87. PMID: 34021235.
    Citations: 2     
  5. Munn LL, Stylianopoulos T, Jain NK, Hardin CC, Khandekar MJ, Jain RK. Vascular Normalization to Improve Treatment of COVID-19: Lessons from Treatment of Cancer. Clin Cancer Res. 2021 05 15; 27(10):2706-2711. PMID: 33648989.
    Citations:    Fields:    Translation:HumansPHPublic Health
  6. Voutouri C, Nikmaneshi MR, Hardin CC, Patel AB, Verma A, Khandekar MJ, Dutta S, Stylianopoulos T, Munn LL, Jain RK. In silico dynamics of COVID-19 phenotypes for optimizing clinical management. Proc Natl Acad Sci U S A. 2021 01 19; 118(3). PMID: 33402434.
    Citations: 2     Fields:    Translation:Humans
  7. Keane FK, Driscoll E, Bowes C, Durgin B, Khandekar MJ, Willers H. Low Rates of Chest Wall Toxicity When Individualizing the Planning Target Volume Margin in Patients With Early Stage Lung Cancer Treated With Stereotactic Body Radiation Therapy. Pract Radiat Oncol. 2021 May-Jun; 11(3):e282-e291. PMID: 33239160.
    Citations:    Fields:    Translation:Humans
  8. Voutouri C, Nikmaneshi MR, Hardin CC, Patel AB, Verma A, Khandekar MJ, Dutta S, Stylianopoulos T, Munn LL, Jain RK. In silico dynamics of COVID-19 phenotypes for optimizing clinical management. Res Sq. 2020 Sep 03. PMID: 32908974.
  9. Lebow ES, Hwang WL, Zieminski S, Wang Y, Niemierko A, Mehan WA, Oh KS, Khandekar M, Willers H, Shih HA. Early experience with hippocampal avoidance whole brain radiation therapy and simultaneous integrated boost for brain metastases. J Neurooncol. 2020 May; 148(1):81-88. PMID: 32307637.
    Citations:    Fields:    Translation:HumansPHPublic Health
  10. Li Y, Dykstra M, Best TD, Pursley J, Chopra N, Keane FK, Khandekar MJ, Sharp GC, Paganetti H, Willers H, Fintelmann FJ, Grassberger C. Differential inflammatory response dynamics in normal lung following stereotactic body radiation therapy with protons versus photons. Radiother Oncol. 2019 07; 136:169-175. PMID: 31015121.
    Citations: 3     Fields:    Translation:Humans
  11. Khandekar MJ, Piotrowska Z, Willers H, Sequist LV. Role of Epidermal Growth Factor Receptor (EGFR) Inhibitors and Radiation in the Management of Brain Metastases from EGFR Mutant Lung Cancers. Oncologist. 2018 09; 23(9):1054-1062. PMID: 29703765.
    Citations: 3     Fields:    Translation:Humans
  12. Zieminski S, Khandekar M, Wang Y. Assessment of multi-criteria optimization (MCO) for volumetric modulated arc therapy (VMAT) in hippocampal avoidance whole brain radiation therapy (HA-WBRT). J Appl Clin Med Phys. 2018 Mar; 19(2):184-190. PMID: 29411526.
    Citations: 3     Fields:    Translation:Humans
  13. Khandekar MJ, Jain R. Smooth sailing for immunotherapy for unresectable stage III non-small cell lung cancer: the PACIFIC study. Transl Cancer Res. 2018 Feb; 7(Suppl 1):S16-S20. PMID: 30175050.
    Citations: 4     
  14. Khandekar MJ, Banks AS, Laznik-Bogoslavski D, White JP, Choi JH, Kazak L, Lo JC, Cohen P, Wong KK, Kamenecka TM, Griffin PR, Spiegelman BM. Noncanonical agonist PPAR? ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy. Proc Natl Acad Sci U S A. 2018 01 16; 115(3):561-566. PMID: 29295932.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  15. Campo M, Al-Halabi H, Khandekar M, Shaw AT, Sequist LV, Willers H. Integration of Stereotactic Body Radiation Therapy With Tyrosine Kinase Inhibitors in Stage IV Oncogene-Driven Lung Cancer. Oncologist. 2016 08; 21(8):964-73. PMID: 27354669.
    Citations: 11     Fields:    Translation:Humans
  16. Lo JC, Ljubicic S, Leibiger B, Kern M, Leibiger IB, Moede T, Kelly ME, Chatterjee Bhowmick D, Murano I, Cohen P, Banks AS, Khandekar MJ, Dietrich A, Flier JS, Cinti S, Blüher M, Danial NN, Berggren PO, Spiegelman BM. Adipsin is an adipokine that improves ß cell function in diabetes. Cell. 2014 Jul 03; 158(1):41-53. PMID: 24995977.
    Citations: 100     Fields:    Translation:HumansAnimalsCells
  17. Cohen P, Levy JD, Zhang Y, Frontini A, Kolodin DP, Svensson KJ, Lo JC, Zeng X, Ye L, Khandekar MJ, Wu J, Gunawardana SC, Banks AS, Camporez JP, Jurczak MJ, Kajimura S, Piston DW, Mathis D, Cinti S, Shulman GI, Seale P, Spiegelman BM. Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell. 2014 Jan 16; 156(1-2):304-16. PMID: 24439384.
    Citations: 313     Fields:    Translation:AnimalsCells
  18. Ye L, Wu J, Cohen P, Kazak L, Khandekar MJ, Jedrychowski MP, Zeng X, Gygi SP, Spiegelman BM. Fat cells directly sense temperature to activate thermogenesis. Proc Natl Acad Sci U S A. 2013 Jul 23; 110(30):12480-5. PMID: 23818608.
    Citations: 97     Fields:    Translation:AnimalsCells
  19. Khandekar MJ, Raut CP, Hornick JL, Wang Q, Alexander BM, Baldini EH. Paratesticular liposarcoma: unusual patterns of recurrence and importance of margins. Ann Surg Oncol. 2013 Jul; 20(7):2148-55. PMID: 23591942.
    Citations: 5     Fields:    Translation:Humans
  20. Ye L, Kleiner S, Wu J, Sah R, Gupta RK, Banks AS, Cohen P, Khandekar MJ, Boström P, Mepani RJ, Laznik D, Kamenecka TM, Song X, Liedtke W, Mootha VK, Puigserver P, Griffin PR, Clapham DE, Spiegelman BM. TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell. 2012 Sep 28; 151(1):96-110. PMID: 23021218.
    Citations: 126     Fields:    Translation:AnimalsCells
  21. Wu J, Boström P, Sparks LM, Ye L, Choi JH, Giang AH, Khandekar M, Virtanen KA, Nuutila P, Schaart G, Huang K, Tu H, van Marken Lichtenbelt WD, Hoeks J, Enerbäck S, Schrauwen P, Spiegelman BM. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell. 2012 Jul 20; 150(2):366-76. PMID: 22796012.
    Citations: 1115     Fields:    Translation:HumansAnimalsCells
  22. Gupta RK, Mepani RJ, Kleiner S, Lo JC, Khandekar MJ, Cohen P, Frontini A, Bhowmick DC, Ye L, Cinti S, Spiegelman BM. Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells. Cell Metab. 2012 Feb 08; 15(2):230-9. PMID: 22326224.
    Citations: 165     Fields:    Translation:AnimalsCells
  23. Khandekar MJ, Cohen P, Spiegelman BM. Molecular mechanisms of cancer development in obesity. Nat Rev Cancer. 2011 11 24; 11(12):886-95. PMID: 22113164.
    Citations: 300     Fields:    Translation:HumansAnimalsCells
  24. Truong MT, Nadgir RN, Hirsch AE, Subramaniam RM, Wang JW, Wu R, Khandekar M, Nawaz AO, Sakai O. Brachial plexus contouring with CT and MR imaging in radiation therapy planning for head and neck cancer. Radiographics. 2010 Jul-Aug; 30(4):1095-103. PMID: 20631370.
    Citations: 15     Fields:    Translation:Humans
  25. Julia S. Wong, Melin J. Khandekar. Challenges and Considerations in the Management of Ductal Carcinoma In Situ. 2008.
  26. Hoshino T, Shimizu R, Ohmori S, Nagano M, Pan X, Ohneda O, Khandekar M, Yamamoto M, Lim KC, Engel JD. Reduced BMP4 abundance in Gata2 hypomorphic mutant mice result in uropathies resembling human CAKUT. Genes Cells. 2008 Feb; 13(2):159-70. PMID: 18233958.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  27. Brandt W, Khandekar M, Suzuki N, Yamamoto M, Lim KC, Engel JD. Defining the functional boundaries of the Gata2 locus by rescue with a linked bacterial artificial chromosome transgene. J Biol Chem. 2008 Apr 04; 283(14):8976-83. PMID: 18211891.
    Citations: 7     Fields:    Translation:AnimalsCells
  28. Khandekar M, Brandt W, Zhou Y, Dagenais S, Glover TW, Suzuki N, Shimizu R, Yamamoto M, Lim KC, Engel JD. A Gata2 intronic enhancer confers its pan-endothelia-specific regulation. Development. 2007 May; 134(9):1703-12. PMID: 17395646.
    Citations: 49     Fields:    Translation:AnimalsCells
  29. Khandekar J, Khandekar M. Phase 1 clinical trials: not just for safety anymore? Arch Intern Med. 2006 Jul 24; 166(14):1440-1. PMID: 16864752.
    Citations: 2     Fields:    Translation:Humans
  30. Khandekar M. Function and regulation of transcription factor Gata2. 2006.
  31. Khandekar M, Suzuki N, Lewton J, Yamamoto M, Engel JD. Multiple, distant Gata2 enhancers specify temporally and tissue-specific patterning in the developing urogenital system. Mol Cell Biol. 2004 Dec; 24(23):10263-76. PMID: 15542836.
    Citations: 30     Fields:    Translation:AnimalsCells
  32. Khandekar M., Zhou Y., Lim K.C., Engel J.D. Identification of a Gata2 urogenital enhancer in BAC transgenic mice. Poster Presentation. 2003.
  33. Khandekar M., Zhou Y., Lim K.C., Engel J.D. A BAC transgenic approach to identifying a Gata2 urogenital enhancer. Oral Presentation. 2002.
  34. Gaudry C.A., Palka H.L., Dusek R.L., Huen A.C., Khandekar M.J., Hudson L.G., Green K.J. Tyrosine phosphorylated plakoglobin is associated with desmogleins but not desmoplakin after epidermal growth factor receptor activation. Journal of Biological Chemistry. 2001; 276(27):24871-24880.
  35. Gaudry CA, Palka HL, Dusek RL, Huen AC, Khandekar MJ, Hudson LG, Green KJ. Tyrosine-phosphorylated plakoglobin is associated with desmogleins but not desmoplakin after epidermal growth factor receptor activation. J Biol Chem. 2001 Jul 06; 276(27):24871-80. PMID: 11335725.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  36. Khandekar M., Zhou Y., Engel J.D. Function and regulation of Gata2 in vascular development. Poster Presentation. 2001.
  37. Khandekar M., Pennacchio L., Myers R.M. Characterization of the distribution of Cystatin B in the brain of M. Musculus. Poster presentation. 1998.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.