Harvard Catalyst Profiles

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Christopher Alexander French, M.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01AI075104 (FRENCH, CHRISTOPHER A) Jul 23, 2009 - Jun 30, 2011
    NIH
    IQGAP1 in microbial pathogenesis
    Role: Principal Investigator
  2. R21NS063875 (FRENCH, CHRISTOPHER A) Jun 5, 2009 - May 31, 2011
    NIH
    High throughput screen to identify inhibitors of Salmonella invasion
    Role: Principal Investigator
  3. R01CA124633 (FRENCH, CHRISTOPHER A) Aug 30, 2007 - May 31, 2023
    NIH
    Pathogenesis and Treatment of NUT-Midline Carcinoma
    Role: Principal Investigator
  4. K08CA092158 (FRENCH, CHRISTOPHER A) Jul 5, 2002 - Jun 30, 2007
    NIH
    T(15;19) in Aggressive Pediatric Carcinoma
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Testa-Silva G, Rosier M, Honnuraiah S, Guzulaitis R, Megias AM, French C, King J, Drummond K, Palmer LM, Stuart GJ. High synaptic threshold for dendritic NMDA spike generation in human layer 2/3 pyramidal neurons. Cell Rep. 2022 12 13; 41(11):111787. PMID: 36516769.
    Citations:    Fields:    Translation:HumansCells
  2. Barletta JA, Gilday SD, Afkhami M, Bell D, Bocklage T, Boisselier P, Chau NG, Cipriani NA, Costes-Martineau V, Ghossein RA, Hertzler HJ, Kramer AM, Limaye S, Lopez CA, Ng TL, Weissferdt A, Xu B, Zhang S, French CA. NUTM1 -rearranged Carcinoma of the Thyroid : A Distinct Subset of NUT Carcinoma Characterized by Frequent NSD3 - NUTM1 Fusions. Am J Surg Pathol. 2022 12 01; 46(12):1706-1715. PMID: 36040068; PMCID: PMC9669222.
    Citations: 1     Fields:    Translation:Humans
  3. French CA, Cheng ML, Hanna GJ, DuBois SG, Chau NG, Hann CL, Storck S, Salgia R, Trucco M, Tseng J, Stathis A, Piekarz R, Lauer UM, Massard C, Bennett K, Coker S, Tontsch-Grunt U, Sos ML, Liao S, Wu CJ, Polyak K, Piha-Paul SA, Shapiro GI. Report of the First International Symposium on NUT Carcinoma. Clin Cancer Res. 2022 06 13; 28(12):2493-2505. PMID: 35417004; PMCID: PMC9197941.
    Citations: 1     Fields:    Translation:Humans
  4. Ohnesorge PV, Berchtold S, Beil J, Haas SA, Smirnow I, Schenk A, French CA, Luong NM, Huang Y, Fehrenbacher B, Schaller M, Lauer UM. Efficacy of Oncolytic Herpes Simplex Virus T-VEC Combined with BET Inhibitors as an Innovative Therapy Approach for NUT Carcinoma. Cancers (Basel). 2022 Jun 02; 14(11). PMID: 35681742; PMCID: PMC9179288.
    Citations:    
  5. Abreu RF, Oliveira TB, Hertzler H, Toledo RN, D'Almeida Costa F, Lopes Pinto CA, Nunes WA, Nascimento AF, French CA, Nascimento AG. NUT carcinoma, an under-recognized malignancy: a clinicopathologic and molecular series of 6 cases showing a subset of patients with better prognosis and a rare ZNF532::NUTM1 fusion. Hum Pathol. 2022 08; 126:87-99. PMID: 35623465.
    Citations:    Fields:    
  6. Agaimy A, Haller F, Renner A, Niedermeyer J, Hartmann A, French CA. Misleading Germ Cell Phenotype in Pulmonary NUT Carcinoma Harboring the ZNF532-NUTM1 Fusion. Am J Surg Pathol. 2022 02 01; 46(2):281-288. PMID: 34232599; PMCID: PMC8741879.
    Citations: 3     Fields:    Translation:HumansCells
  7. Moreno V, French CA, Guo T, Zhu H, Zhang S, Duncan D, Karni RJ, Blanco AI, Jafri SH, Saluja K. NUT Carcinoma of the Submandibular Gland: A Case at This Uncommon Site with Review of the Literature. Head Neck Pathol. 2022 Sep; 16(3):881-892. PMID: 34905155; PMCID: PMC9424374.
    Citations: 1     Fields:    
  8. Cousin S, Blay JY, Garcia IB, de Bono JS, Le Tourneau C, Moreno V, Trigo J, Hann CL, Azad AA, Im SA, Cassier PA, French CA, Italiano A, Keedy VL, Plummer R, Sablin MP, Hemming ML, Ferron-Brady G, Wyce A, Khaled A, Datta A, Foley SW, McCabe MT, Wu Y, Horner T, Kremer BE, Dhar A, O'Dwyer PJ, Shapiro GI, Piha-Paul SA. Safety, pharmacokinetic, pharmacodynamic and clinical activity of molibresib for the treatment of nuclear protein in testis carcinoma and other cancers: Results of a Phase I/II open-label, dose escalation study. Int J Cancer. 2022 03 15; 150(6):993-1006. PMID: 34724226.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  9. Marx A, Chan JKC, Chalabreysse L, Dacic S, Detterbeck F, French CA, Hornick JL, Inagaki H, Jain D, Lazar AJ, Marino M, Marom EM, Moreira AL, Nicholson AG, Noguchi M, Nonaka D, Papotti MG, Porubsky S, Sholl LM, Tateyama H, Thomas de Montpréville V, Travis WD, Rajan A, Roden AC, Ströbel P. The 2021 WHO Classification of Tumors of the Thymus and Mediastinum: What Is New in Thymic Epithelial, Germ Cell, and Mesenchymal Tumors? J Thorac Oncol. 2022 02; 17(2):200-213. PMID: 34695605.
    Citations: 6     Fields:    Translation:HumansCells
  10. Shiota H, Alekseyenko AA, Wang ZA, Filic I, Knox TM, Luong NM, Huang Y, Scott DA, Jones KL, Gokhale PC, Lemieux ME, Cole PA, Kuroda MI, French CA. Chemical Screen Identifies Diverse and Novel Histone Deacetylase Inhibitors as Repressors of NUT Function: Implications for NUT Carcinoma Pathogenesis and Treatment. Mol Cancer Res. 2021 11; 19(11):1818-1830. PMID: 34285087; PMCID: PMC8568634.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  11. Leeman R, Pinkney K, Bradley JA, Ruiz R, DuBois SG, French C, Trucco M. NUT Carcinoma Without Upfront Surgical Resection: A Case Report. J Pediatr Hematol Oncol. 2021 07 01; 43(5):e707-e710. PMID: 32555033; PMCID: PMC8887700.
    Citations: 2     Fields:    Translation:Humans
  12. Pearson AD, DuBois SG, Buenger V, Kieran M, Stegmaier K, Bandopadhayay P, Bennett K, Bourdeaut F, Brown PA, Chesler L, Clymer J, Fox E, French CA, Germovsek E, Giles FJ, Bender JG, Hattersley MM, Ludwinski D, Luptakova K, Maris J, McDonough J, Nikolova Z, Smith M, Tsiatis AC, Vibhakar R, Weiner S, Yi JS, Zheng F, Vassal G. Bromodomain and extra-terminal inhibitors-A consensus prioritisation after the Paediatric Strategy Forum for medicinal product development of epigenetic modifiers in children-ACCELERATE. Eur J Cancer. 2021 03; 146:115-124. PMID: 33601323.
    Citations: 3     Fields:    Translation:Humans
  13. Eagen KP, French CA. Supercharging BRD4 with NUT in carcinoma. Oncogene. 2021 02; 40(8):1396-1408. PMID: 33452461; PMCID: PMC7914217.
    Citations: 11     Fields:    Translation:HumansCells
  14. Shapiro GI, LoRusso P, Dowlati A, T Do K, Jacobson CA, Vaishampayan U, Weise A, Caimi PF, Eder JP, French CA, Labriola-Tompkins E, Boisserie F, Pierceall WE, Zhi J, Passe S, DeMario M, Kornacker M, Armand P. A Phase 1 study of RO6870810, a novel bromodomain and extra-terminal protein inhibitor, in patients with NUT carcinoma, other solid tumours, or diffuse large B-cell lymphoma. Br J Cancer. 2021 02; 124(4):744-753. PMID: 33311588; PMCID: PMC7884382.
    Citations: 20     Fields:    Translation:HumansCTClinical Trials
  15. McLean-Holden AC, Moore SA, Gagan J, French CA, Sher D, Truelson JM, Bishop JA. NUT Carcinoma in a Patient with Unusually Long Survival and False Negative FISH Results. Head Neck Pathol. 2021 Jun; 15(2):698-703. PMID: 32918711.
    Citations: 5     Fields:    Translation:Humans
  16. Morrison-Smith CD, Knox TM, Filic I, Soroko KM, Eschle BK, Wilkens MK, Gokhale PC, Giles F, Griffin A, Brown B, Shapiro GI, Zucconi BE, Cole PA, Lemieux ME, French CA. Combined Targeting of the BRD4-NUT-p300 Axis in NUT Midline Carcinoma by Dual Selective Bromodomain Inhibitor, NEO2734. Mol Cancer Ther. 2020 07; 19(7):1406-1414. PMID: 32371576.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  17. Zhang X, Zegar T, Lucas A, Morrison-Smith C, Knox T, French CA, Knapp S, Müller S, Siveke JT. Therapeutic targeting of p300/CBP HAT domain for the treatment of NUT midline carcinoma. Oncogene. 2020 06; 39(24):4770-4779. PMID: 32366905.
    Citations: 13     Fields:    Translation:HumansCells
  18. Piha-Paul SA, Hann CL, French CA, Cousin S, Braña I, Cassier PA, Moreno V, de Bono JS, Harward SD, Ferron-Brady G, Barbash O, Wyce A, Wu Y, Horner T, Annan M, Parr NJ, Prinjha RK, Carpenter CL, Hilton J, Hong DS, Haas NB, Markowski MC, Dhar A, O'Dwyer PJ, Shapiro GI. Phase 1 Study of Molibresib (GSK525762), a Bromodomain and Extra-Terminal Domain Protein Inhibitor, in NUT Carcinoma and Other Solid Tumors. JNCI Cancer Spectr. 2020 Apr; 4(2):pkz093. PMID: 32328561; PMCID: PMC7165800.
    Citations: 44     Fields:    
  19. Chau NG, Ma C, Danga K, Al-Sayegh H, Nardi V, Barrette R, Lathan CS, DuBois SG, Haddad RI, Shapiro GI, Sallan SE, Dhar A, Nelson JJ, French CA. An Anatomical Site and Genetic-Based Prognostic Model for Patients With Nuclear Protein in Testis (NUT) Midline Carcinoma: Analysis of 124 Patients. JNCI Cancer Spectr. 2020 Apr; 4(2):pkz094. PMID: 32328562; PMCID: PMC7165803.
    Citations: 31     Fields:    
  20. Laga AC, Schaefer IM, Sholl LM, French CA, Hanna J. Metastatic Basal Cell Carcinoma. Am J Clin Pathol. 2019 11 04; 152(6):706-717. PMID: 31355851; PMCID: PMC6829017.
    Citations: 5     Fields:    Translation:Humans
  21. Diolaiti D, Dela Cruz FS, Gundem G, Bouvier N, Boulad M, Zhang Y, Chou AJ, Dunkel IJ, Sanghvi R, Shah M, Geiger H, Rahman S, Felice V, Wrzeszczynski KO, Darnell RB, Antonescu CR, French CA, Papaemmanuil E, Kung AL, Shukla N. A recurrent novel MGA-NUTM1 fusion identifies a new subtype of high-grade spindle cell sarcoma. Cold Spring Harb Mol Case Stud. 2018 12; 4(6). PMID: 30552129.
    Citations: 8     Fields:    Translation:Humans
  22. Sivathamboo S, Farrand S, Chen Z, White EJ, Pattichis AA, Hollis C, Carino J, Roberts CJ, Minogue T, Jones NC, Yerra R, French C, Perucca P, Kwan P, Velakoulis D, O'Brien TJ, Goldin J. Sleep-disordered breathing among patients admitted for inpatient video-EEG monitoring. Neurology. 2019 01 15; 92(3):e194-e204. PMID: 30552299.
    Citations: 4     Fields:    Translation:Humans
  23. Pelosi G, Cannone M, Balladore E, Rahal D, Bossi P, Novellis P, Bottoni E, Toschi L, Roncalli M, French CA, Veronesi G. Spindle Cell Nuclear in Testis Carcinoma of the Lung: A Challenging Tumor. J Thorac Oncol. 2019 02; 14(2):311-313. PMID: 30476575.
    Citations: 1     Fields:    Translation:Humans
  24. French CA. NUT Carcinoma: Clinicopathologic features, pathogenesis, and treatment. Pathol Int. 2018 Nov; 68(11):583-595. PMID: 30362654.
    Citations: 50     Fields:    Translation:Humans
  25. Shiota H, Elya JE, Alekseyenko AA, Chou PM, Gorman SA, Barbash O, Becht K, Danga K, Kuroda MI, Nardi V, French CA. "Z4" Complex Member Fusions in NUT Carcinoma: Implications for a Novel Oncogenic Mechanism. Mol Cancer Res. 2018 12; 16(12):1826-1833. PMID: 30139738; PMCID: PMC6279489.
    Citations: 15     Fields:    Translation:HumansCells
  26. Schaefer IM, Dal Cin P, Landry LM, Fletcher CDM, Hanna GJ, French CA. CIC-NUTM1 fusion: A case which expands the spectrum of NUT-rearranged epithelioid malignancies. Genes Chromosomes Cancer. 2018 09; 57(9):446-451. PMID: 29700887; PMCID: PMC6881821.
    Citations: 22     Fields:    Translation:Humans
  27. Mito JK, Bishop JA, Sadow PM, Stelow EB, Faquin WC, Mills SE, Krane JF, French CA, Fletcher CDM, Hornick JL, Sholl LM, Jo VY. Immunohistochemical Detection and Molecular Characterization of IDH-mutant Sinonasal Undifferentiated Carcinomas. Am J Surg Pathol. 2018 08; 42(8):1067-1075. PMID: 29683816.
    Citations: 9     Fields:    Translation:Humans
  28. Agaimy A, Fonseca I, Martins C, Thway K, Barrette R, Harrington KJ, Hartmann A, French CA, Fisher C. NUT Carcinoma of the Salivary Glands: Clinicopathologic and Molecular Analysis of 3 Cases and a Survey of NUT Expression in Salivary Gland Carcinomas. Am J Surg Pathol. 2018 07; 42(7):877-884. PMID: 29649019; PMCID: PMC6010176.
    Citations: 21     Fields:    Translation:Humans
  29. Strickland KC, Eszlinger M, Paschke R, Angell TE, Alexander EK, Marqusee E, Nehs MA, Jo VY, Lowe A, Vivero M, Hollowell M, Qian X, Wieczorek T, French CA, Teot LA, Cibas ES, Lindeman NI, Krane JF, Barletta JA. Molecular Testing of Nodules with a Suspicious or Malignant Cytologic Diagnosis in the Setting of Non-Invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP). Endocr Pathol. 2018 Mar; 29(1):68-74. PMID: 29396809.
    Citations: 12     Fields:    Translation:Humans
  30. Canty DJ, Heiberg J, Yang Y, Royse AG, Margale S, Nanjappa N, Scott D, Maier A, Sessler DI, Chuan A, Palmer A, Bucknill A, French C, Royse CF. Pilot multi-centre randomised trial of the impact of pre-operative focused cardiac ultrasound on mortality and morbidity in patients having surgery for femoral neck fractures (ECHONOF-2 pilot). Anaesthesia. 2018 Apr; 73(4):428-437. PMID: 29226957.
    Citations: 9     Fields:    Translation:Humans
  31. Storck S, Kennedy AL, Marcus KJ, Teot L, Vaughn J, Gnekow AK, Märkl B, Leuschner I, DuBois SG, French CA, Frühwald MC. Pediatric NUT-midline carcinoma: Therapeutic success employing a sarcoma based multimodal approach. Pediatr Hematol Oncol. 2017 May; 34(4):231-237. PMID: 29040054.
    Citations: 14     Fields:    Translation:HumansCells
  32. Brägelmann J, Dammert MA, Dietlein F, Heuckmann JM, Choidas A, Böhm S, Richters A, Basu D, Tischler V, Lorenz C, Habenberger P, Fang Z, Ortiz-Cuaran S, Leenders F, Eickhoff J, Koch U, Getlik M, Termathe M, Sallouh M, Greff Z, Varga Z, Balke-Want H, French CA, Peifer M, Reinhardt HC, Örfi L, Kéri G, Ansén S, Heukamp LC, Büttner R, Rauh D, Klebl BM, Thomas RK, Sos ML. Systematic Kinase Inhibitor Profiling Identifies CDK9 as a Synthetic Lethal Target in NUT Midline Carcinoma. Cell Rep. 2017 Sep 19; 20(12):2833-2845. PMID: 28930680.
    Citations: 22     Fields:    Translation:HumansCells
  33. Alekseyenko AA, Walsh EM, Zee BM, Pakozdi T, Hsi P, Lemieux ME, Dal Cin P, Ince TA, Kharchenko PV, Kuroda MI, French CA. Ectopic protein interactions within BRD4-chromatin complexes drive oncogenic megadomain formation in NUT midline carcinoma. Proc Natl Acad Sci U S A. 2017 05 23; 114(21):E4184-E4192. PMID: 28484033; PMCID: PMC5448232.
    Citations: 39     Fields:    Translation:HumansCells
  34. DeFilippis EM, Vaidya A, Ramani S, French C, Kirshenbaum JM. Under Pressure. N Engl J Med. 2017 Mar 30; 376(13):e23. PMID: 28355512.
    Citations:    Fields:    Translation:Humans
  35. Hellquist H, French CA, Bishop JA, Coca-Pelaz A, Propst EJ, Paiva Correia A, Ngan BY, Grant R, Cipriani NA, Vokes D, Henrique R, Pardal F, Vizcaino JR, Rinaldo A, Ferlito A. NUT midline carcinoma of the larynx: an international series and review of the literature. Histopathology. 2017 May; 70(6):861-868. PMID: 27926786; PMCID: PMC5386828.
    Citations: 13     Fields:    Translation:Humans
  36. Zee BM, Dibona AB, Alekseyenko AA, French CA, Kuroda MI. The Oncoprotein BRD4-NUT Generates Aberrant Histone Modification Patterns. PLoS One. 2016; 11(10):e0163820. PMID: 27698495.
    Citations: 7     Fields:    Translation:HumansCells
  37. Strickland KC, Vivero M, Jo VY, Lowe AC, Hollowell M, Qian X, Wieczorek TJ, French CA, Teot LA, Sadow PM, Alexander EK, Cibas ES, Barletta JA, Krane JF. Preoperative Cytologic Diagnosis of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: A Prospective Analysis. Thyroid. 2016 10; 26(10):1466-1471. PMID: 27457786.
    Citations: 28     Fields:    Translation:HumansCells
  38. Shatavi S, Fawole A, Haberichter K, Jaiyesimi I, French C. Nuclear protein in testis (NUT) midline carcinoma with a novel three-way translocation (4;15;19)(q13;q14;p13.1). Pathology. 2016 Oct; 48(6):620-3. PMID: 27590195.
    Citations: 5     Fields:    Translation:HumansCells
  39. Chau NG, Hurwitz S, Mitchell CM, Aserlind A, Grunfeld N, Kaplan L, Hsi P, Bauer DE, Lathan CS, Rodriguez-Galindo C, Tishler RB, Haddad RI, Sallan SE, Bradner JE, French CA. Intensive treatment and survival outcomes in NUT midline carcinoma of the head and neck. Cancer. 2016 Dec 01; 122(23):3632-3640. PMID: 27509377; PMCID: PMC5361614.
    Citations: 59     Fields:    Translation:Humans
  40. Bishop JA, French CA, Ali SZ. Cytopathologic features of NUT midline carcinoma: A series of 26 specimens from 13 patients. Cancer Cytopathol. 2016 Dec; 124(12):901-908. PMID: 27400194.
    Citations: 24     Fields:    Translation:Humans
  41. French CA. Small-Molecule Targeting of BET Proteins in Cancer. Adv Cancer Res. 2016; 131:21-58. PMID: 27451123.
    Citations: 33     Fields:    Translation:Humans
  42. Stathis A, Zucca E, Bekradda M, Gomez-Roca C, Delord JP, de La Motte Rouge T, Uro-Coste E, de Braud F, Pelosi G, French CA. Clinical Response of Carcinomas Harboring the BRD4-NUT Oncoprotein to the Targeted Bromodomain Inhibitor OTX015/MK-8628. Cancer Discov. 2016 05; 6(5):492-500. PMID: 26976114.
    Citations: 115     Fields:    Translation:HumansCells
  43. Andreasen S, French CA, Josiassen M, Hahn CH, Kiss K. NUT Carcinoma of the Sublingual Gland. Head Neck Pathol. 2016 Sep; 10(3):362-6. PMID: 26586234; PMCID: PMC4972746.
    Citations: 11     Fields:    Translation:Humans
  44. Alekseyenko AA, Walsh EM, Wang X, Grayson AR, Hsi PT, Kharchenko PV, Kuroda MI, French CA. The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains. Genes Dev. 2015 Jul 15; 29(14):1507-23. PMID: 26220994; PMCID: PMC4526735.
    Citations: 69     Fields:    Translation:HumansCells
  45. Sholl LM, Nishino M, Pokharel S, Mino-Kenudson M, French CA, Janne PA, Lathan C. Primary Pulmonary NUT Midline Carcinoma: Clinical, Radiographic, and Pathologic Characterizations. J Thorac Oncol. 2015 Jun; 10(6):951-9. PMID: 26001144; PMCID: PMC4443847.
    Citations: 30     Fields:    Translation:Humans
  46. Dragoescu E, French C, Cassano A, Baker S, Chafe W. NUT midline carcinoma presenting with bilateral ovarian metastases: a case report. Int J Gynecol Pathol. 2015 Mar; 34(2):136-42. PMID: 25675182.
    Citations: 2     Fields:    Translation:Humans
  47. Bair RJ, Chick JF, Chauhan NR, French C, Madan R. Demystifying NUT midline carcinoma: radiologic and pathologic correlations of an aggressive malignancy. AJR Am J Roentgenol. 2014 Oct; 203(4):W391-9. PMID: 25247968.
    Citations: 14     Fields:    Translation:Humans
  48. Boiteux C, Vorobyov I, French RJ, French C, Yarov-Yarovoy V, Allen TW. Local anesthetic and antiepileptic drug access and binding to a bacterial voltage-gated sodium channel. Proc Natl Acad Sci U S A. 2014 Sep 09; 111(36):13057-62. PMID: 25136136.
    Citations: 44     Fields:    Translation:Cells
  49. French CA, Rahman S, Walsh EM, Kühnle S, Grayson AR, Lemieux ME, Grunfeld N, Rubin BP, Antonescu CR, Zhang S, Venkatramani R, Dal Cin P, Howley PM. NSD3-NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism. Cancer Discov. 2014 Aug; 4(8):928-41. PMID: 24875858; PMCID: PMC4125436.
    Citations: 84     Fields:    Translation:HumansCells
  50. Wang R, Liu W, Helfer CM, Bradner JE, Hornick JL, Janicki SM, French CA, You J. Activation of SOX2 expression by BRD4-NUT oncogenic fusion drives neoplastic transformation in NUT midline carcinoma. Cancer Res. 2014 Jun 15; 74(12):3332-43. PMID: 24736545.
    Citations: 23     Fields:    Translation:HumansCells
  51. French C. NUT midline carcinoma. Nat Rev Cancer. 2014 03; 14(3):149-50. PMID: 25688404.
    Citations: 50     Fields:    Translation:Humans
  52. Puliyel MM, Mascarenhas L, Zhou S, Sapra A, Dal Cin P, French CA, Venkatramani R. Nuclear protein in testis midline carcinoma misdiagnosed as adamantinoma. J Clin Oncol. 2014 May 20; 32(15):e57-60. PMID: 24470009; PMCID: PMC4876346.
    Citations: 4     Fields:    Translation:Humans
  53. Parikh SA, French CA, Costello BA, Marks RS, Dronca RS, Nerby CL, Roden AC, Peddareddigari VG, Hilton J, Shapiro GI, Molina JR. NUT midline carcinoma: an aggressive intrathoracic neoplasm. J Thorac Oncol. 2013 Oct; 8(10):1335-8. PMID: 24457244.
    Citations: 18     Fields:    Translation:Humans
  54. Hakami T, McIntosh A, Todaro M, Lui E, Yerra R, Tan KM, French C, Li S, Desmond P, Matkovic Z, O'Brien TJ. MRI-identified pathology in adults with new-onset seizures. Neurology. 2013 Sep 03; 81(10):920-7. PMID: 23925763.
    Citations: 16     Fields:    Translation:Humans
  55. Maffini F, French CA, Cameron MJ, Stufano V, Barberis M, Pisa E, Manzotti M, Cattaneo A, De Fiori E, Viale G. A case of NUT midline carcinoma with no HPV infection, slight EWSR1 rearrangement and strong expression of EGFR. Tumori. 2013 Jul-Aug; 99(4):e152-5. PMID: 24326851.
    Citations: 4     Fields:    Translation:Humans
  56. Grayson AR, Walsh EM, Cameron MJ, Godec J, Ashworth T, Ambrose JM, Aserlind AB, Wang H, Evan G, Kluk MJ, Bradner JE, Aster JC, French CA. MYC, a downstream target of BRD-NUT, is necessary and sufficient for the blockade of differentiation in NUT midline carcinoma. Oncogene. 2014 Mar 27; 33(13):1736-1742. PMID: 23604113.
    Citations: 79     Fields:    Translation:Humans
  57. French C, Goyal P. Submucosal resection of the middle turbinate. Laryngoscope. 2013 Aug; 123(8):1845-8. PMID: 23553341.
    Citations:    Fields:    Translation:Humans
  58. French CA. The importance of diagnosing NUT midline carcinoma. Head Neck Pathol. 2013 Mar; 7(1):11-6. PMID: 23463074; PMCID: PMC3597165.
    Citations: 33     Fields:    Translation:Humans
  59. Russell SM, Lechner MG, Mokashi A, Megiel C, Jang JK, Taylor CR, Looijenga LH, French CA, Epstein AL. Establishment and characterization of a new human extragonadal germ cell line, SEM-1, and its comparison with TCam-2 and JKT-1. Urology. 2013 Feb; 81(2):464.e1-9. PMID: 23374840; PMCID: PMC4179199.
    Citations: 9     Fields:    Translation:HumansCells
  60. Ball A, Bromley A, Glaze S, French CA, Ghatage P, Köbel M. A rare case of NUT midline carcinoma. Gynecol Oncol Case Rep. 2012; 3:1-3. PMID: 24371650.
    Citations: 11     
  61. Bauer DE, Mitchell CM, Strait KM, Lathan CS, Stelow EB, Lüer SC, Muhammed S, Evans AG, Sholl LM, Rosai J, Giraldi E, Oakley RP, Rodriguez-Galindo C, London WB, Sallan SE, Bradner JE, French CA. Clinicopathologic features and long-term outcomes of NUT midline carcinoma. Clin Cancer Res. 2012 Oct 15; 18(20):5773-9. PMID: 22896655; PMCID: PMC3473162.
    Citations: 113     Fields:    Translation:Humans
  62. Fang W, French CA, Cameron MJ, Han YD, Liu HG. [Utility of NUT gene expression and rearrangement in diagnosis of NUT midline carcinoma in upper respiratory tract]. Zhonghua Bing Li Xue Za Zhi. 2012 Aug; 41(8):519-24. PMID: 23157742.
    Citations: 2     Fields:    Translation:Humans
  63. Wartchow EP, Moore TS, French CA, Mierau GW. Ultrastructural features of NUT midline carcinoma. Ultrastruct Pathol. 2012 Aug; 36(4):280-4. PMID: 22849529.
    Citations: 3     Fields:    Translation:Humans
  64. Evans AG, French CA, Cameron MJ, Fletcher CD, Jackman DM, Lathan CS, Sholl LM. Pathologic characteristics of NUT midline carcinoma arising in the mediastinum. Am J Surg Pathol. 2012 Aug; 36(8):1222-7. PMID: 22790861; PMCID: PMC3396884.
    Citations: 36     Fields:    Translation:Humans
  65. Fang W, French CA, Cameron MJ, Han Y, Liu H. Clinicopathological significance of NUT rearrangements in poorly differentiated malignant tumors of the upper respiratory tract. Int J Surg Pathol. 2013 Apr; 21(2):102-10. PMID: 22777717.
    Citations: 9     Fields:    Translation:Humans
  66. Petrini P, French CA, Rajan A, Cameron MJ, Jaffe ES, Zucali PA, Xie J, Wang Y, Giaccone G. NUT rearrangement is uncommon in human thymic epithelial tumors. J Thorac Oncol. 2012 Apr; 7(4):744-50. PMID: 22425924; PMCID: PMC3308127.
    Citations: 7     Fields:    Translation:Humans
  67. Lee CH, Ou WB, Mariño-Enriquez A, Zhu M, Mayeda M, Wang Y, Guo X, Brunner AL, Amant F, French CA, West RB, McAlpine JN, Gilks CB, Yaffe MB, Prentice LM, McPherson A, Jones SJ, Marra MA, Shah SP, van de Rijn M, Huntsman DG, Dal Cin P, Debiec-Rychter M, Nucci MR, Fletcher JA. 14-3-3 fusion oncogenes in high-grade endometrial stromal sarcoma. Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):929-34. PMID: 22223660.
    Citations: 69     Fields:    Translation:HumansCells
  68. Davis BN, Karabakhtsian RG, Pettigrew AL, Arnold SM, French CA, Brill YM. Nuclear protein in testis midline carcinomas: a lethal and underrecognized entity. Arch Pathol Lab Med. 2011 Nov; 135(11):1494-8. PMID: 22032580.
    Citations: 6     Fields:    Translation:Humans
  69. French CA. Pathogenesis of NUT midline carcinoma. Annu Rev Pathol. 2012; 7:247-65. PMID: 22017582.
    Citations: 105     Fields:    Translation:Humans
  70. Niederkohr RD, Cameron MJ, French CA. FDG PET/CT imaging of NUT midline carcinoma. Clin Nucl Med. 2011 Sep; 36(9):e124-6. PMID: 21825839.
    Citations: 3     Fields:    Translation:Humans
  71. Laury AR, Perets R, Piao H, Krane JF, Barletta JA, French C, Chirieac LR, Lis R, Loda M, Hornick JL, Drapkin R, Hirsch MS. A comprehensive analysis of PAX8 expression in human epithelial tumors. Am J Surg Pathol. 2011 Jun; 35(6):816-26. PMID: 21552115.
    Citations: 116     Fields:    Translation:HumansCells
  72. Schwartz BE, Hofer MD, Lemieux ME, Bauer DE, Cameron MJ, West NH, Agoston ES, Reynoird N, Khochbin S, Ince TA, Christie A, Janeway KA, Vargas SO, Perez-Atayde AR, Aster JC, Sallan SE, Kung AL, Bradner JE, French CA. Differentiation of NUT midline carcinoma by epigenomic reprogramming. Cancer Res. 2011 Apr 01; 71(7):2686-96. PMID: 21447744; PMCID: PMC3070805.
    Citations: 72     Fields:    Translation:HumansAnimalsCells
  73. Teo M, Crotty P, O'Sullivan M, French CA, Walshe JM. NUT midline carcinoma in a young woman. J Clin Oncol. 2011 Apr 20; 29(12):e336-9. PMID: 21263084.
    Citations: 10     Fields:    Translation:Humans
  74. Zhu B, Laskin W, Chen Y, French CA, Cameron MJ, Nayar R, Lin X. NUT midline carcinoma: a neoplasm with diagnostic challenges in cytology. Cytopathology. 2011 Dec; 22(6):414-7. PMID: 21210877.
    Citations: 8     Fields:    Translation:Humans
  75. French CA. NUT midline carcinoma. Cancer Genet Cytogenet. 2010 Nov; 203(1):16-20. PMID: 20951314; PMCID: PMC3000636.
    Citations: 50     Fields:    Translation:Humans
  76. Fujioka N, French CA, Cameron MJ, Kratzke RA. Long-term survival of a patient with squamous cell carcinoma harboring NUT gene rearrangement. J Thorac Oncol. 2010 Oct; 5(10):1704-5. PMID: 20871268.
    Citations: 8     Fields:    Translation:Humans
  77. Filippakopoulos P, Qi J, Picaud S, Shen Y, Smith WB, Fedorov O, Morse EM, Keates T, Hickman TT, Felletar I, Philpott M, Munro S, McKeown MR, Wang Y, Christie AL, West N, Cameron MJ, Schwartz B, Heightman TD, La Thangue N, French CA, Wiest O, Kung AL, Knapp S, Bradner JE. Selective inhibition of BET bromodomains. Nature. 2010 Dec 23; 468(7327):1067-73. PMID: 20871596; PMCID: PMC3010259.
    Citations: 1704     Fields:    Translation:HumansAnimalsCells
  78. Nelson BA, Lee EY, French CA, Bauer DE, Vargas SO. BRD4-NUT carcinoma of the mediastinum in a pediatric patient: multidetector computed tomography imaging findings. J Thorac Imaging. 2010 Aug; 25(3):W93-6. PMID: 20395873.
    Citations: 9     Fields:    Translation:Humans
  79. Reynoird N, Schwartz BE, Delvecchio M, Sadoul K, Meyers D, Mukherjee C, Caron C, Kimura H, Rousseaux S, Cole PA, Panne D, French CA, Khochbin S. Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains. EMBO J. 2010 Sep 01; 29(17):2943-52. PMID: 20676058; PMCID: PMC2944051.
    Citations: 82     Fields:    Translation:HumansAnimalsCells
  80. Ziai J, French CA, Zambrano E. NUT gene rearrangement in a poorly-differentiated carcinoma of the submandibular gland. Head Neck Pathol. 2010 Jun; 4(2):163-8. PMID: 20352379; PMCID: PMC2878624.
    Citations: 28     Fields:    Translation:Humans
  81. Bellizzi AM, Bruzzi C, French CA, Stelow EB. The cytologic features of NUT midline carcinoma. Cancer. 2009 Dec 25; 117(6):508-15. PMID: 19795508.
    Citations: 15     Fields:    Translation:HumansCells
  82. Hsieh MS, French CA, Liang CW, Hsiao CH. NUT midline carcinoma: case report and review of the literature. Int J Surg Pathol. 2011 Dec; 19(6):808-12. PMID: 20034986.
    Citations: 6     Fields:    Translation:Humans
  83. Shehata BM, Steelman CK, Abramowsky CR, Olson TA, French CA, Saxe DF, Ricketts RR, Katzenstein HM. NUT midline carcinoma in a newborn with multiorgan disseminated tumor and a 2-year-old with a pancreatic/hepatic primary. Pediatr Dev Pathol. 2010 Nov-Dec; 13(6):481-5. PMID: 20017639.
    Citations: 28     Fields:    Translation:HumansCells
  84. den Bakker MA, Beverloo BH, van den Heuvel-Eibrink MM, Meeuwis CA, Tan LM, Johnson LA, French CA, van Leenders GJ. NUT midline carcinoma of the parotid gland with mesenchymal differentiation. Am J Surg Pathol. 2009 Aug; 33(8):1253-8. PMID: 19561446.
    Citations: 38     Fields:    Translation:Humans
  85. Haack H, Johnson LA, Fry CJ, Crosby K, Polakiewicz RD, Stelow EB, Hong SM, Schwartz BE, Cameron MJ, Rubin MA, Chang MC, Aster JC, French CA. Diagnosis of NUT midline carcinoma using a NUT-specific monoclonal antibody. Am J Surg Pathol. 2009 Jul; 33(7):984-91. PMID: 19363441; PMCID: PMC2783402.
    Citations: 111     Fields:    Translation:HumansAnimals
  86. Stelow EB, French CA. Carcinomas of the upper aerodigestive tract with rearrangement of the nuclear protein of the testis (NUT) gene (NUT midline carcinomas). Adv Anat Pathol. 2009 Mar; 16(2):92-6. PMID: 19550370.
    Citations: 21     Fields:    Translation:Humans
  87. Joos B, Joos N, Bumpous J, Burns C, French CA, Farghaly H. Laryngeal squamous cell carcinoma in a 13 year-old child associated with human papillomaviruses 16 and 18: a case report and review of the literature. Head Neck Pathol. 2009 Mar; 3(1):37-41. PMID: 20596987.
    Citations: 3     Fields:    Translation:HumansCells
  88. French CA. Demystified molecular pathology of NUT midline carcinomas. J Clin Pathol. 2010 Jun; 63(6):492-6. PMID: 18552174.
    Citations: 54     Fields:    Translation:Humans
  89. Stelow EB, Bellizzi AM, Taneja K, Mills SE, Legallo RD, Kutok JL, Aster JC, French CA. NUT rearrangement in undifferentiated carcinomas of the upper aerodigestive tract. Am J Surg Pathol. 2008 Jun; 32(6):828-34. PMID: 18391746.
    Citations: 66     Fields:    Translation:Humans
  90. French CA, Fletcher JA, Cibas ES, Caulfield C, Allard P, Kroll TG. Molecular detection of PPAR gamma rearrangements and thyroid carcinoma in preoperative fine-needle aspiration biopsies. Endocr Pathol. 2008; 19(3):166-74. PMID: 18688583.
    Citations: 3     Fields:    Translation:Humans
  91. Mertens F, Wiebe T, Adlercreutz C, Mandahl N, French CA. Successful treatment of a child with t(15;19)-positive tumor. Pediatr Blood Cancer. 2007 Dec; 49(7):1015-7. PMID: 16435379.
    Citations: 44     Fields:    Translation:HumansCells
  92. French CA, Ramirez CL, Kolmakova J, Hickman TT, Cameron MJ, Thyne ME, Kutok JL, Toretsky JA, Tadavarthy AK, Kees UR, Fletcher JA, Aster JC. BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells. Oncogene. 2008 Apr 03; 27(15):2237-42. PMID: 17934517.
    Citations: 157     Fields:    Translation:HumansCells
  93. Oliveira AM, French CA. Applications of fluorescence in situ hybridization in cytopathology: a review. Acta Cytol. 2005 Nov-Dec; 49(6):587-94. PMID: 16450896.
    Citations: 2     Fields:    Translation:HumansAnimals
  94. French CA, Kutok JL, Faquin WC, Toretsky JA, Antonescu CR, Griffin CA, Nose V, Vargas SO, Moschovi M, Tzortzatou-Stathopoulou F, Miyoshi I, Perez-Atayde AR, Aster JC, Fletcher JA. Midline carcinoma of children and young adults with NUT rearrangement. J Clin Oncol. 2004 Oct 15; 22(20):4135-9. PMID: 15483023.
    Citations: 114     Fields:    Translation:HumansCells
  95. Rahbar R, Vargas SO, Miyamoto CR, Perez-Atayde AR, French CA, Robson CD, Licameli GR, Fletcher JA, Marcus KC, Grier HE, McGill TJ, Healy GB. The role of chromosomal translocation (15;19) in the carcinoma of the upper aerodigestive tract in children. Otolaryngol Head Neck Surg. 2003 Dec; 129(6):698-704. PMID: 14663438.
    Citations: 5     Fields:    Translation:HumansCells
  96. French CA, Alexander EK, Cibas ES, Nose V, Laguette J, Faquin W, Garber J, Moore F, Fletcher JA, Larsen PR, Kroll TG. Genetic and biological subgroups of low-stage follicular thyroid cancer. Am J Pathol. 2003 Apr; 162(4):1053-60. PMID: 12651598; PMCID: PMC1851238.
    Citations: 41     Fields:    Translation:Humans
  97. French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15; 63(2):304-7. PMID: 12543779.
    Citations: 182     Fields:    Translation:HumansCells
  98. French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec; 159(6):1987-92. PMID: 11733348; PMCID: PMC1850578.
    Citations: 77     Fields:    Translation:HumansCells
  99. Vargas SO, French CA, Faul PN, Fletcher JA, Davis IJ, Dal Cin P, Perez-Atayde AR. Upper respiratory tract carcinoma with chromosomal translocation 15;19: evidence for a distinct disease entity of young patients with a rapidly fatal course. Cancer. 2001 Sep 01; 92(5):1195-203. PMID: 11571733.
    Citations: 20     Fields:    Translation:HumansCells
  100. French CA, Mentzel T, Kutzner H, Fletcher CD. Intradermal spindle cell/pleomorphic lipoma: a distinct subset. Am J Dermatopathol. 2000 Dec; 22(6):496-502. PMID: 11190440.
    Citations: 4     Fields:    Translation:Humans
  101. French CA, Dorfman DM, Shaheen G, Cibas ES. Diagnosing lymphoproliferative disorders involving the cerebrospinal fluid: increased sensitivity using flow cytometric analysis. Diagn Cytopathol. 2000 Dec; 23(6):369-74. PMID: 11074639.
    Citations: 12     Fields:    Translation:Humans
  102. French CA, Bieber FR, Bing DH, Genest DR. Twins, placentas, and genetics: acardiac twinning in a dichorionic, diamniotic, monozygotic twin gestation. Hum Pathol. 1998 Sep; 29(9):1028-31. PMID: 9744324.
    Citations: 4     Fields:    Translation:Humans
  103. Zack DJ, Yamamoto K, Wong AL, Stempniak M, French C, Weisbart RH. DNA mimics a self-protein that may be a target for some anti-DNA antibodies in systemic lupus erythematosus. J Immunol. 1995 Feb 15; 154(4):1987-94. PMID: 7836777.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  104. Mooney RA, Peterson CJ, French CA, Saller DN, Arvan DA. Effectiveness of combining maternal serum alpha-fetoprotein and hCG in a second-trimester screening program for Down syndrome. Obstet Gynecol. 1994 Aug; 84(2):298-303. PMID: 7518896.
    Citations: 8     Fields:    Translation:Humans
  105. Mooney RA, McGorty BL, French CA, Arvan DA. An alpha-fetoprotein radioimmunoassay for use in maternal serum screening for Down's syndrome: limitations and improvements. Clin Chim Acta. 1988 Feb 15; 171(2-3):325-31. PMID: 2453312.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.