Harvard Catalyst Profiles

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Peter M. Howley, M.D.

Other Positions

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R35CA197262 (HOWLEY, PETER M) Jan 1, 2016 - Dec 31, 2022
    Molecular Biology of Oncogenic Papillomaviruses
    Role: Principal Investigator
  2. R21CA175473 (HOWLEY, PETER M) Jul 1, 2013 - Jun 30, 2015
    Small Molecule Screen Targeting p53 proteolysis in HPV positive cancers
    Role: Principal Investigator
  3. RC1CA145188 (HARPER, JEFFREY WADE) Sep 30, 2009 - Aug 31, 2011
    Oncogenic Human Papillomavirus Protein Network
    Role: Co-Principal Investigator
  4. R01CA116720 (HOWLEY, PETER M) Apr 1, 2006 - Jun 30, 2017
    Papillomavirus E2 Functions: Cellular Regulation and Effectors
    Role: Principal Investigator
  5. R01AI057183 (HOWLEY, PETER M) Mar 15, 2003 - Feb 29, 2008
    The Roles of IRF-3 in the Cellular Response to Viral Infection
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Kühnle S, Martínez-Noël G, Leclere F, Hayes SD, Harper JW, Howley PM. Angelman syndrome-associated point mutations in the Zn2+-binding N-terminal (AZUL) domain of UBE3A ubiquitin ligase inhibit binding to the proteasome. J Biol Chem. 2018 11 23; 293(47):18387-18399. PMID: 30257870.
    Citations: 1     Fields:    
  2. Bentley P, Tan MJA, McBride AA, White EA, Howley PM. The SMC5/6 Complex Interacts with the Papillomavirus E2 Protein and Influences Maintenance of Viral Episomal DNA. J Virol. 2018 08 01; 92(15). PMID: 29848583.
    Citations:    Fields:    
  3. Chiang C, Pauli EK, Biryukov J, Feister KF, Meng M, White EA, Münger K, Howley PM, Meyers C, Gack MU. The Human Papillomavirus E6 Oncoprotein Targets USP15 and TRIM25 To Suppress RIG-I-Mediated Innate Immune Signaling. J Virol. 2018 03 15; 92(6). PMID: 29263274.
    Citations: 1     Fields:    Translation:HumansCells
  4. Martínez-Noël G, Luck K, Kühnle S, Desbuleux A, Szajner P, Galligan JT, Rodriguez D, Zheng L, Boyland K, Leclere F, Zhong Q, Hill DE, Vidal M, Howley PM. Network Analysis of UBE3A/E6AP-Associated Proteins Provides Connections to Several Distinct Cellular Processes. J Mol Biol. 2018 03 30; 430(7):1024-1050. PMID: 29426014.
    Citations: 1     Fields:    
  5. Cheng J, Park DE, Berrios C, White EA, Arora R, Yoon R, Branigan T, Xiao T, Westerling T, Federation A, Zeid R, Strober B, Swanson SK, Florens L, Bradner JE, Brown M, Howley PM, Padi M, Washburn MP, DeCaprio JA. Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis. PLoS Pathog. 2017 Oct; 13(10):e1006668. PMID: 29028833.
    Citations: 2     Fields:    Translation:HumansCells
  6. White EA, Münger K, Howley PM. High-Risk Human Papillomavirus E7 Proteins Target PTPN14 for Degradation. mBio. 2016 09 20; 7(5). PMID: 27651363.
    Citations: 9     Fields:    Translation:HumansCells
  7. Ali SM, Pal SK, Wang K, Palma NA, Sanford E, Bailey M, He J, Elvin JA, Chmielecki J, Squillace R, Dow E, Morosini D, Buell J, Yelensky R, Lipson D, Frampton GM, Howley P, Ross JS, Stephens PJ, Miller VA. Comprehensive Genomic Profiling of Advanced Penile Carcinoma Suggests a High Frequency of Clinically Relevant Genomic Alterations. Oncologist. 2016 Jan; 21(1):33-9. PMID: 26670666.
    Citations: 7     Fields:    Translation:Humans
  8. Howley PM, Pfister HJ. Beta genus papillomaviruses and skin cancer. Virology. 2015 May; 479-480:290-6. PMID: 25724416.
    Citations: 33     Fields:    Translation:HumansCells
  9. Howley PM. Gordon Wilson Lecture: Infectious Disease Causes of Cancer: Opportunities for Prevention and Treatment. Trans Am Clin Climatol Assoc. 2015; 126:117-32. PMID: 26330666.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  10. White EA, Kramer RE, Hwang JH, Pores Fernando AT, Naetar N, Hahn WC, Roberts TM, Schaffhausen BS, Livingston DM, Howley PM. Papillomavirus E7 oncoproteins share functions with polyomavirus small T antigens. J Virol. 2015 Mar; 89(5):2857-65. PMID: 25540383.
    Citations: 5     Fields:    Translation:HumansCells
  11. Vieira VC, Leonard B, White EA, Starrett GJ, Temiz NA, Lorenz LD, Lee D, Soares MA, Lambert PF, Howley PM, Harris RS. Human papillomavirus E6 triggers upregulation of the antiviral and cancer genomic DNA deaminase APOBEC3B. mBio. 2014 Dec 23; 5(6). PMID: 25538195.
    Citations: 43     Fields:    Translation:HumansCells
  12. Galligan JT, Martinez-Noël G, Arndt V, Hayes S, Chittenden TW, Harper JW, Howley PM. Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. J Proteome Res. 2015 Feb 06; 14(2):953-66. PMID: 25476789.
    Citations: 12     Fields:    Translation:Humans
  13. Smith JA, Haberstroh FS, White EA, Livingston DM, DeCaprio JA, Howley PM. SMCX and components of the TIP60 complex contribute to E2 regulation of the HPV E6/E7 promoter. Virology. 2014 Nov; 468-470:311-321. PMID: 25222147.
    Citations: 7     Fields:    Translation:HumansCells
  14. French CA, Rahman S, Walsh EM, Kühnle S, Grayson AR, Lemieux ME, Grunfeld N, Rubin BP, Antonescu CR, Zhang S, Venkatramani R, Dal Cin P, Howley PM. NSD3-NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism. Cancer Discov. 2014 Aug; 4(8):928-41. PMID: 24875858.
    Citations: 37     Fields:    Translation:HumansCells
  15. White EA, Walther J, Javanbakht H, Howley PM. Genus beta human papillomavirus E6 proteins vary in their effects on the transactivation of p53 target genes. J Virol. 2014 Aug; 88(15):8201-12. PMID: 24850740.
    Citations: 13     Fields:    Translation:HumansCells
  16. Howley P. Examining farm forest owners' forest management in Ireland: the role of economic, lifestyle and multifunctional ownership objectives. J Environ Manage. 2013 Jul 15; 123:105-12. PMID: 23590944.
    Citations:    Fields:    Translation:HumansAnimals
  17. White EA, Howley PM. Proteomic approaches to the study of papillomavirus-host interactions. Virology. 2013 Jan 05; 435(1):57-69. PMID: 23217616.
    Citations: 23     Fields:    Translation:HumansCells
  18. White EA, Kramer RE, Tan MJ, Hayes SD, Harper JW, Howley PM. Comprehensive analysis of host cellular interactions with human papillomavirus E6 proteins identifies new E6 binding partners and reflects viral diversity. J Virol. 2012 Dec; 86(24):13174-86. PMID: 23015706.
    Citations: 49     Fields:    Translation:HumansCells
  19. Martínez-Noël G, Galligan JT, Sowa ME, Arndt V, Overton TM, Harper JW, Howley PM. Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes. Mol Cell Biol. 2012 Aug; 32(15):3095-106. PMID: 22645313.
    Citations: 36     Fields:    Translation:HumansCells
  20. Tan MJ, White EA, Sowa ME, Harper JW, Aster JC, Howley PM. Cutaneous ß-human papillomavirus E6 proteins bind Mastermind-like coactivators and repress Notch signaling. Proc Natl Acad Sci U S A. 2012 Jun 05; 109(23):E1473-80. PMID: 22547818.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  21. White EA, Sowa ME, Tan MJ, Jeudy S, Hayes SD, Santha S, Münger K, Harper JW, Howley PM. Systematic identification of interactions between host cell proteins and E7 oncoproteins from diverse human papillomaviruses. Proc Natl Acad Sci U S A. 2012 Jan 31; 109(5):E260-7. PMID: 22232672.
    Citations: 59     Fields:    Translation:HumansCells
  22. Rahman S, Sowa ME, Ottinger M, Smith JA, Shi Y, Harper JW, Howley PM. The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. Mol Cell Biol. 2011 Jul; 31(13):2641-52. PMID: 21555454.
    Citations: 137     Fields:    Translation:HumansCells
  23. Powell ML, Smith JA, Sowa ME, Harper JW, Iftner T, Stubenrauch F, Howley PM. NCoR1 mediates papillomavirus E8;E2C transcriptional repression. J Virol. 2010 May; 84(9):4451-60. PMID: 20181716.
    Citations: 16     Fields:    Translation:HumansCells
  24. Smith JA, White EA, Sowa ME, Powell ML, Ottinger M, Harper JW, Howley PM. Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3752-7. PMID: 20133580.
    Citations: 55     Fields:    Translation:HumansCells
  25. Fradet-Turcotte A, Brault K, Titolo S, Howley PM, Archambault J. Characterization of papillomavirus E1 helicase mutants defective for interaction with the SUMO-conjugating enzyme Ubc9. Virology. 2009 Dec 20; 395(2):190-201. PMID: 19836047.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  26. Ottinger M, Smith JA, Schweiger MR, Robbins D, Powell ML, You J, Howley PM. Cell-type specific transcriptional activities among different papillomavirus long control regions and their regulation by E2. Virology. 2009 Dec 20; 395(2):161-71. PMID: 19836046.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  27. You J, Li Q, Wu C, Kim J, Ottinger M, Howley PM. Regulation of aurora B expression by the bromodomain protein Brd4. Mol Cell Biol. 2009 Sep; 29(18):5094-103. PMID: 19596781.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  28. Vos RM, Altreuter J, White EA, Howley PM. The ubiquitin-specific peptidase USP15 regulates human papillomavirus type 16 E6 protein stability. J Virol. 2009 Sep; 83(17):8885-92. PMID: 19553310.
    Citations: 29     Fields:    Translation:HumansCells
  29. Zheng G, Schweiger MR, Martinez-Noel G, Zheng L, Smith JA, Harper JW, Howley PM. Brd4 regulation of papillomavirus protein E2 stability. J Virol. 2009 Sep; 83(17):8683-92. PMID: 19553317.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  30. Howley PM, Livingston DM. Small DNA tumor viruses: large contributors to biomedical sciences. Virology. 2009 Feb 20; 384(2):256-9. PMID: 19136134.
    Citations: 29     Fields:    Translation:HumansCells
  31. Mulligan P, Westbrook TF, Ottinger M, Pavlova N, Chang B, Macia E, Shi YJ, Barretina J, Liu J, Howley PM, Elledge SJ, Shi Y. CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation. Mol Cell. 2008 Dec 05; 32(5):718-26. PMID: 19061646.
    Citations: 54     Fields:    Translation:HumansCells
  32. Goh AM, Walters KJ, Elsasser S, Verma R, Deshaies RJ, Finley D, Howley PM. Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins. BMC Biochem. 2008 Jan 30; 9:4. PMID: 18234089.
    Citations: 11     Fields:    Translation:HumansCells
  33. Schweiger MR, Ottinger M, You J, Howley PM. Brd4-independent transcriptional repression function of the papillomavirus e2 proteins. J Virol. 2007 Sep; 81(18):9612-22. PMID: 17626100.
    Citations: 35     Fields:    Translation:HumansCells
  34. DeMasi J, Chao MC, Kumar AS, Howley PM. Bovine papillomavirus E7 oncoprotein inhibits anoikis. J Virol. 2007 Sep; 81(17):9419-25. PMID: 17596310.
    Citations: 13     Fields:    Translation:Cells
  35. Shirakura M, Murakami K, Ichimura T, Suzuki R, Shimoji T, Fukuda K, Abe K, Sato S, Fukasawa M, Yamakawa Y, Nishijima M, Moriishi K, Matsuura Y, Wakita T, Suzuki T, Howley PM, Miyamura T, Shoji I. E6AP ubiquitin ligase mediates ubiquitylation and degradation of hepatitis C virus core protein. J Virol. 2007 Feb; 81(3):1174-85. PMID: 17108031.
    Citations: 31     Fields:    Translation:HumansCells
  36. You J, Srinivasan V, Denis GV, Harrington WJ, Ballestas ME, Kaye KM, Howley PM. Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomes. J Virol. 2006 Sep; 80(18):8909-19. PMID: 16940503.
    Citations: 80     Fields:    Translation:HumansCells
  37. Schweiger MR, You J, Howley PM. Bromodomain protein 4 mediates the papillomavirus E2 transcriptional activation function. J Virol. 2006 May; 80(9):4276-85. PMID: 16611886.
    Citations: 69     Fields:    Translation:HumansCells
  38. Nishimura A, Nakahara T, Ueno T, Sasaki K, Yoshida S, Kyo S, Howley PM, Sakai H. Requirement of E7 oncoprotein for viability of HeLa cells. Microbes Infect. 2006 Apr; 8(4):984-93. PMID: 16500131.
    Citations: 11     Fields:    Translation:HumansCells
  39. Howley PM. Warts, cancer and ubiquitylation: lessons from the papillomaviruses. Trans Am Clin Climatol Assoc. 2006; 117:113-26; discussion 126-7. PMID: 18528468.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  40. You J, Schweiger MR, Howley PM. Inhibition of E2 binding to Brd4 enhances viral genome loss and phenotypic reversion of bovine papillomavirus-transformed cells. J Virol. 2005 Dec; 79(23):14956-61. PMID: 16282494.
    Citations: 33     Fields:    Translation:AnimalsCells
  41. Li L, Li Z, Howley PM, Sacks DB. E6AP and calmodulin reciprocally regulate estrogen receptor stability. J Biol Chem. 2006 Jan 27; 281(4):1978-85. PMID: 16314411.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  42. DeMasi J, Huh KW, Nakatani Y, Münger K, Howley PM. Bovine papillomavirus E7 transformation function correlates with cellular p600 protein binding. Proc Natl Acad Sci U S A. 2005 Aug 09; 102(32):11486-91. PMID: 16081543.
    Citations: 29     Fields:    Translation:Cells
  43. Huh KW, DeMasi J, Ogawa H, Nakatani Y, Howley PM, Münger K. Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600. Proc Natl Acad Sci U S A. 2005 Aug 09; 102(32):11492-7. PMID: 16061792.
    Citations: 76     Fields:    Translation:HumansCells
  44. Kirshner JR, Karpova AY, Kops M, Howley PM. Identification of TRAIL as an interferon regulatory factor 3 transcriptional target. J Virol. 2005 Jul; 79(14):9320-4. PMID: 15994827.
    Citations: 25     Fields:    Translation:HumansCells
  45. Bossis I, Roden RB, Gambhira R, Yang R, Tagaya M, Howley PM, Meneses PI. Interaction of tSNARE syntaxin 18 with the papillomavirus minor capsid protein mediates infection. J Virol. 2005 Jun; 79(11):6723-31. PMID: 15890910.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  46. Walters KJ, Goh AM, Wang Q, Wagner G, Howley PM. Ubiquitin family proteins and their relationship to the proteasome: a structural perspective. Biochim Biophys Acta. 2004 Nov 29; 1695(1-3):73-87. PMID: 15571810.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  47. Cooper EM, Hudson AW, Amos J, Wagstaff J, Howley PM. Biochemical analysis of Angelman syndrome-associated mutations in the E3 ubiquitin ligase E6-associated protein. J Biol Chem. 2004 Sep 24; 279(39):41208-17. PMID: 15263005.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  48. You J, Croyle JL, Nishimura A, Ozato K, Howley PM. Interaction of the bovine papillomavirus E2 protein with Brd4 tethers the viral DNA to host mitotic chromosomes. Cell. 2004 Apr 30; 117(3):349-60. PMID: 15109495.
    Citations: 168     Fields:    Translation:HumansAnimalsCells
  49. Gibberd R, Hancock S, Howley P, Richards K. Using indicators to quantify the potential to improve the quality of health care. Int J Qual Health Care. 2004 Apr; 16 Suppl 1:i37-43. PMID: 15059985.
    Citations: 11     Fields:    Translation:Humans
  50. Hudson AW, Blom D, Howley PM, Ploegh HL. The ER-lumenal domain of the HHV-7 immunoevasin U21 directs class I MHC molecules to lysosomes. Traffic. 2003 Dec; 4(12):824-37. PMID: 14617346.
    Citations: 7     Fields:    Translation:HumansCells
  51. Wang Q, Goh AM, Howley PM, Walters KJ. Ubiquitin recognition by the DNA repair protein hHR23a. Biochemistry. 2003 Nov 25; 42(46):13529-35. PMID: 14621999.
    Citations: 28     Fields:    Translation:HumansCells
  52. Walters KJ, Lech PJ, Goh AM, Wang Q, Howley PM. DNA-repair protein hHR23a alters its protein structure upon binding proteasomal subunit S5a. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12694-9. PMID: 14557549.
    Citations: 33     Fields:    Translation:HumansCells
  53. Kleijnen MF, Alarcon RM, Howley PM. The ubiquitin-associated domain of hPLIC-2 interacts with the proteasome. Mol Biol Cell. 2003 Sep; 14(9):3868-75. PMID: 12972570.
    Citations: 31     Fields:    Translation:HumansCells
  54. Wells SI, Aronow BJ, Wise TM, Williams SS, Couget JA, Howley PM. Transcriptome signature of irreversible senescence in human papillomavirus-positive cervical cancer cells. Proc Natl Acad Sci U S A. 2003 Jun 10; 100(12):7093-8. PMID: 12756294.
    Citations: 24     Fields:    Translation:HumansCells
  55. Münger K, Howley PM. Human papillomavirus immortalization and transformation functions. Virus Res. 2002 Nov; 89(2):213-28. PMID: 12445661.
    Citations: 190     Fields:    Translation:HumansCells
  56. Karpova AY, Trost M, Murray JM, Cantley LC, Howley PM. Interferon regulatory factor-3 is an in vivo target of DNA-PK. Proc Natl Acad Sci U S A. 2002 Mar 05; 99(5):2818-23. PMID: 11867762.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  57. Walters KJ, Kleijnen MF, Goh AM, Wagner G, Howley PM. Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a. Biochemistry. 2002 Feb 12; 41(6):1767-77. PMID: 11827521.
    Citations: 73     Fields:    Translation:HumansCells
  58. Hudson AW, Howley PM, Ploegh HL. A human herpesvirus 7 glycoprotein, U21, diverts major histocompatibility complex class I molecules to lysosomes. J Virol. 2001 Dec; 75(24):12347-58. PMID: 11711625.
    Citations: 15     Fields:    Translation:HumansCells
  59. Karpova AY, Ronco LV, Howley PM. Functional characterization of interferon regulatory factor 3a (IRF-3a), an alternative splice isoform of IRF-3. Mol Cell Biol. 2001 Jul; 21(13):4169-76. PMID: 11390646.
    Citations: 17     Fields:    Translation:HumansCells
  60. Hancock L, Sanson-Fisher R, Perkins J, Girgis A, Howley P, Schofield M. The effect of a community action intervention on adolescent smoking rates in rural australian towns: the CART project. Cancer Action in Rural Towns. Prev Med. 2001 Apr; 32(4):332-40. PMID: 11304094.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  61. Hancock L, Sanson-Fisher R, Perkins J, McClintock A, Howley P, Gibberd R. Effect of a community action program on adult quit smoking rates in rural australian towns: the CART project. Prev Med. 2001 Feb; 32(2):118-27. PMID: 11162337.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  62. Karpova AY, Howley PM, Ronco LV. Dual utilization of an acceptor/donor splice site governs the alternative splicing of the IRF-3 gene. Genes Dev. 2000 Nov 15; 14(22):2813-8. PMID: 11090129.
    Citations: 13     Fields:    Translation:HumansCells
  63. Wells SI, Francis DA, Karpova AY, Dowhanick JJ, Benson JD, Howley PM. Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways. EMBO J. 2000 Nov 01; 19(21):5762-71. PMID: 11060027.
    Citations: 57     Fields:    Translation:HumansCells
  64. Zhou P, Bogacki R, McReynolds L, Howley PM. Harnessing the ubiquitination machinery to target the degradation of specific cellular proteins. Mol Cell. 2000 Sep; 6(3):751-6. PMID: 11030355.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  65. Kleijnen MF, Shih AH, Zhou P, Kumar S, Soccio RE, Kedersha NL, Gill G, Howley PM. The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome. Mol Cell. 2000 Aug; 6(2):409-19. PMID: 10983987.
    Citations: 133     Fields:    Translation:HumansAnimalsCells
  66. Kao WH, Beaudenon SL, Talis AL, Huibregtse JM, Howley PM. Human papillomavirus type 16 E6 induces self-ubiquitination of the E6AP ubiquitin-protein ligase. J Virol. 2000 Jul; 74(14):6408-17. PMID: 10864652.
    Citations: 40     Fields:    Translation:HumansCells
  67. Nishimura A, Ono T, Ishimoto A, Dowhanick JJ, Frizzell MA, Howley PM, Sakai H. Mechanisms of human papillomavirus E2-mediated repression of viral oncogene expression and cervical cancer cell growth inhibition. J Virol. 2000 Apr; 74(8):3752-60. PMID: 10729150.
    Citations: 36     Fields:    Translation:HumansCells
  68. Bellamy SL, Gibberd R, Hancock L, Howley P, Kennedy B, Klar N, Lipsitz S, Ryan L. Analysis of dichotomous outcome data for community intervention studies. Stat Methods Med Res. 2000 Apr; 9(2):135-59. PMID: 10946431.
    Citations: 11     Fields:    Translation:Humans
  69. Francis DA, Schmid SI, Howley PM. Repression of the integrated papillomavirus E6/E7 promoter is required for growth suppression of cervical cancer cells. J Virol. 2000 Mar; 74(6):2679-86. PMID: 10684283.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  70. Harris KF, Shoji I, Cooper EM, Kumar S, Oda H, Howley PM. Ubiquitin-mediated degradation of active Src tyrosine kinase. Proc Natl Acad Sci U S A. 1999 Nov 23; 96(24):13738-43. PMID: 10570142.
    Citations: 49     Fields:    Translation:AnimalsCells
  71. Huang L, Kinnucan E, Wang G, Beaudenon S, Howley PM, Huibregtse JM, Pavletich NP. Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade. Science. 1999 Nov 12; 286(5443):1321-6. PMID: 10558980.
    Citations: 155     Fields:    Translation:HumansCells
  72. Oda H, Kumar S, Howley PM. Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination. Proc Natl Acad Sci U S A. 1999 Aug 17; 96(17):9557-62. PMID: 10449731.
    Citations: 49     Fields:    Translation:AnimalsCells
  73. Kumar S, Talis AL, Howley PM. Identification of HHR23A as a substrate for E6-associated protein-mediated ubiquitination. J Biol Chem. 1999 Jun 25; 274(26):18785-92. PMID: 10373495.
    Citations: 68     Fields:    Translation:HumansCells
  74. Unger T, Sionov RV, Moallem E, Yee CL, Howley PM, Oren M, Haupt Y. Mutations in serines 15 and 20 of human p53 impair its apoptotic activity. Oncogene. 1999 May 27; 18(21):3205-12. PMID: 10359526.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  75. Howley PM, Lafont B, Spehner D, Kaelin K, Billeter MA, Drillien R. A functional measles virus replication and transcription machinery encoded by the vaccinia virus genome. J Virol Methods. 1999 Apr; 79(1):65-74. PMID: 10328536.
    Citations: 4     Fields:    Translation:Cells
  76. Benson JD, Benson M, Howley PM, Struhl K. Association of distinct yeast Not2 functional domains with components of Gcn5 histone acetylase and Ccr4 transcriptional regulatory complexes. EMBO J. 1998 Nov 16; 17(22):6714-22. PMID: 9822614.
    Citations: 19     Fields:    Translation:HumansCells
  77. Zhou P, Howley PM. Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligases. Mol Cell. 1998 Nov; 2(5):571-80. PMID: 9844630.
    Citations: 100     Fields:    Translation:Animals
  78. Kasukawa H, Howley PM, Benson JD. A fifteen-amino-acid peptide inhibits human papillomavirus E1-E2 interaction and human papillomavirus DNA replication in vitro. J Virol. 1998 Oct; 72(10):8166-73. PMID: 9733858.
    Citations: 6     Fields:    Translation:Cells
  79. Grossman SR, Perez M, Kung AL, Joseph M, Mansur C, Xiao ZX, Kumar S, Howley PM, Livingston DM. p300/MDM2 complexes participate in MDM2-mediated p53 degradation. Mol Cell. 1998 Oct; 2(4):405-15. PMID: 9809062.
    Citations: 123     Fields:    Translation:HumansCells
  80. Patrick GN, Zhou P, Kwon YT, Howley PM, Tsai LH. p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway. J Biol Chem. 1998 Sep 11; 273(37):24057-64. PMID: 9727024.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  81. Ronco LV, Karpova AY, Vidal M, Howley PM. Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity. Genes Dev. 1998 Jul 01; 12(13):2061-72. PMID: 9649509.
    Citations: 176     Fields:    Translation:HumansAnimalsCells
  82. Talis AL, Huibregtse JM, Howley PM. The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells. J Biol Chem. 1998 Mar 13; 273(11):6439-45. PMID: 9497376.
    Citations: 88     Fields:    Translation:HumansCells
  83. Wathelet MG, Lin CH, Parekh BS, Ronco LV, Howley PM, Maniatis T. Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo. Mol Cell. 1998 Mar; 1(4):507-18. PMID: 9660935.
    Citations: 263     Fields:    Translation:HumansAnimalsCells
  84. Tong X, Boll W, Kirchhausen T, Howley PM. Interaction of the bovine papillomavirus E6 protein with the clathrin adaptor complex AP-1. J Virol. 1998 Jan; 72(1):476-82. PMID: 9420248.
    Citations: 16     Fields:    Translation:AnimalsCells
  85. Tong X, Salgia R, Li JL, Griffin JD, Howley PM. The bovine papillomavirus E6 protein binds to the LD motif repeats of paxillin and blocks its interaction with vinculin and the focal adhesion kinase. J Biol Chem. 1997 Dec 26; 272(52):33373-6. PMID: 9407131.
    Citations: 28     Fields:    Translation:AnimalsCells
  86. Benson JD, Lawande R, Howley PM. Conserved interaction of the papillomavirus E2 transcriptional activator proteins with human and yeast TFIIB proteins. J Virol. 1997 Oct; 71(10):8041-7. PMID: 9311902.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  87. Yasugi T, Vidal M, Sakai H, Howley PM, Benson JD. Two classes of human papillomavirus type 16 E1 mutants suggest pleiotropic conformational constraints affecting E1 multimerization, E2 interaction, and interaction with cellular proteins. J Virol. 1997 Aug; 71(8):5942-51. PMID: 9223484.
    Citations: 21     Fields:    Translation:HumansCells
  88. Spehner D, Drillien R, Howley PM. The assembly of the measles virus nucleoprotein into nucleocapsid-like particles is modulated by the phosphoprotein. Virology. 1997 Jun 09; 232(2):260-8. PMID: 9191839.
    Citations: 19     Fields:    Translation:AnimalsCells
  89. Kumar S, Kao WH, Howley PM. Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity. J Biol Chem. 1997 May 23; 272(21):13548-54. PMID: 9153201.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  90. Tong X, Howley PM. The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton. Proc Natl Acad Sci U S A. 1997 Apr 29; 94(9):4412-7. PMID: 9114003.
    Citations: 71     Fields:    Translation:AnimalsCells
  91. Yamamoto Y, Huibregtse JM, Howley PM. The human E6-AP gene (UBE3A) encodes three potential protein isoforms generated by differential splicing. Genomics. 1997 Apr 15; 41(2):263-6. PMID: 9143503.
    Citations: 33     Fields:    Translation:HumansCells
  92. Yasugi T, Benson JD, Sakai H, Vidal M, Howley PM. Mapping and characterization of the interaction domains of human papillomavirus type 16 E1 and E2 proteins. J Virol. 1997 Feb; 71(2):891-9. PMID: 8995605.
    Citations: 30     Fields:    Translation:HumansCells
  93. Howley PM, Gatehouse JA. A 38 bp repeat sequence within the pea seed storage protein promoter of legA is a binding site for a nuclear DNA-binding protein. Plant Mol Biol. 1997 Jan; 33(1):175-80. PMID: 9037169.
    Citations:    Fields:    Translation:AnimalsCells
  94. Maki CG, Howley PM. Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation. Mol Cell Biol. 1997 Jan; 17(1):355-63. PMID: 8972216.
    Citations: 67     Fields:    Translation:HumansCells
  95. Howley PM, Spehner D, Drillien R. A vaccinia virus transfer vector using a GUS reporter gene inserted into the I4L locus. Gene. 1996 Jun 26; 172(2):233-7. PMID: 8682309.
    Citations: 5     Fields:    Translation:AnimalsCells
  96. Maki CG, Huibregtse JM, Howley PM. In vivo ubiquitination and proteasome-mediated degradation of p53(1). Cancer Res. 1996 Jun 01; 56(11):2649-54. PMID: 8653711.
    Citations: 146     Fields:    Translation:HumansCells
  97. Yasugi T, Howley PM. Identification of the structural and functional human homolog of the yeast ubiquitin conjugating enzyme UBC9. Nucleic Acids Res. 1996 Jun 01; 24(11):2005-10. PMID: 8668529.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  98. Khleif SN, DeGregori J, Yee CL, Otterson GA, Kaye FJ, Nevins JR, Howley PM. Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity. Proc Natl Acad Sci U S A. 1996 Apr 30; 93(9):4350-4. PMID: 8633069.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  99. Arbeit JM, Howley PM, Hanahan D. Chronic estrogen-induced cervical and vaginal squamous carcinogenesis in human papillomavirus type 16 transgenic mice. Proc Natl Acad Sci U S A. 1996 Apr 02; 93(7):2930-5. PMID: 8610145.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  100. Sakai H, Yasugi T, Benson JD, Dowhanick JJ, Howley PM. Targeted mutagenesis of the human papillomavirus type 16 E2 transactivation domain reveals separable transcriptional activation and DNA replication functions. J Virol. 1996 Mar; 70(3):1602-11. PMID: 8627680.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  101. Dowhanick JJ, McBride AA, Howley PM. Suppression of cellular proliferation by the papillomavirus E2 protein. J Virol. 1995 Dec; 69(12):7791-9. PMID: 7494290.
    Citations: 74     Fields:    Translation:HumansAnimalsCells
  102. Benson JD, Howley PM. Amino-terminal domains of the bovine papillomavirus type 1 E1 and E2 proteins participate in complex formation. J Virol. 1995 Jul; 69(7):4364-72. PMID: 7769698.
    Citations: 30     Fields:    Translation:Cells
  103. Huibregtse JM, Scheffner M, Beaudenon S, Howley PM. A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. Proc Natl Acad Sci U S A. 1995 May 23; 92(11):5249. PMID: 7761480.
    Citations: 56     Fields:    Translation:AnimalsCells
  104. Huibregtse JM, Scheffner M, Beaudenon S, Howley PM. A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. Proc Natl Acad Sci U S A. 1995 Mar 28; 92(7):2563-7. PMID: 7708685.
    Citations: 207     Fields:    Translation:HumansAnimalsCells
  105. Vande Pol SB, Howley PM. Negative regulation of the bovine papillomavirus E5, E6, and E7 oncogenes by the viral E1 and E2 genes. J Virol. 1995 Jan; 69(1):395-402. PMID: 7983735.
    Citations: 12     Fields:    Translation:AnimalsCells
  106. Scheffner M, Huibregtse JM, Howley PM. Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53. Proc Natl Acad Sci U S A. 1994 Sep 13; 91(19):8797-801. PMID: 8090726.
    Citations: 78     Fields:    Translation:Cells
  107. Arbeit JM, Münger K, Howley PM, Hanahan D. Progressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic mice. J Virol. 1994 Jul; 68(7):4358-68. PMID: 7515971.
    Citations: 72     Fields:    Translation:AnimalsCells
  108. Scheffner M, Romanczuk H, Münger K, Huibregtse JM, Mietz JA, Howley PM. Functions of human papillomavirus proteins. Curr Top Microbiol Immunol. 1994; 186:83-99. PMID: 8205847.
    Citations: 23     Fields:    Translation:HumansCells
  109. Huibregtse JM, Scheffner M, Howley PM. E6-AP directs the HPV E6-dependent inactivation of p53 and is representative of a family of structurally and functionally related proteins. Cold Spring Harb Symp Quant Biol. 1994; 59:237-45. PMID: 7587075.
    Citations: 13     Fields:    Translation:HumansCells
  110. Scheffner M, Huibregtse JM, Vierstra RD, Howley PM. The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell. 1993 Nov 05; 75(3):495-505. PMID: 8221889.
    Citations: 609     Fields:    Translation:HumansCells
  111. Unger T, Mietz JA, Scheffner M, Yee CL, Howley PM. Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression. Mol Cell Biol. 1993 Sep; 13(9):5186-94. PMID: 8355677.
    Citations: 31     Fields:    Translation:AnimalsCells
  112. Huibregtse JM, Scheffner M, Howley PM. Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins. Mol Cell Biol. 1993 Aug; 13(8):4918-27. PMID: 8393140.
    Citations: 110     Fields:    Translation:Cells
  113. Arbeit JM, Münger K, Howley PM, Hanahan D. Neuroepithelial carcinomas in mice transgenic with human papillomavirus type 16 E6/E7 ORFs. Am J Pathol. 1993 Apr; 142(4):1187-97. PMID: 8386443.
    Citations: 15     Fields:    Translation:AnimalsCells
  114. Huibregtse JM, Scheffner M, Howley PM. Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53. Mol Cell Biol. 1993 Feb; 13(2):775-84. PMID: 8380895.
    Citations: 159     Fields:    Translation:HumansAnimalsCells
  115. Mietz JA, Unger T, Huibregtse JM, Howley PM. The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein. EMBO J. 1992 Dec; 11(13):5013-20. PMID: 1464323.
    Citations: 110     Fields:    Translation:HumansCells
  116. Del Vecchio AM, Romanczuk H, Howley PM, Baker CC. Transient replication of human papillomavirus DNAs. J Virol. 1992 Oct; 66(10):5949-58. PMID: 1326651.
    Citations: 74     Fields:    Translation:HumansCells
  117. McBride AA, Klausner RD, Howley PM. Conserved cysteine residue in the DNA-binding domain of the bovine papillomavirus type 1 E2 protein confers redox regulation of the DNA-binding activity in vitro. Proc Natl Acad Sci U S A. 1992 Aug 15; 89(16):7531-5. PMID: 1323841.
    Citations: 30     Fields:    Translation:AnimalsCells
  118. Scheffner M, Takahashi T, Huibregtse JM, Minna JD, Howley PM. Interaction of the human papillomavirus type 16 E6 oncoprotein with wild-type and mutant human p53 proteins. J Virol. 1992 Aug; 66(8):5100-5. PMID: 1321290.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  119. Lichy JH, Modi WS, Seuanez HN, Howley PM. Identification of a human chromosome 11 gene which is differentially regulated in tumorigenic and nontumorigenic somatic cell hybrids of HeLa cells. Cell Growth Differ. 1992 Aug; 3(8):541-8. PMID: 1390339.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  120. Scheffner M, Münger K, Huibregtse JM, Howley PM. Targeted degradation of the retinoblastoma protein by human papillomavirus E7-E6 fusion proteins. EMBO J. 1992 Jul; 11(7):2425-31. PMID: 1321031.
    Citations: 25     Fields:    Translation:HumansCells
  121. Thierry F, Spyrou G, Yaniv M, Howley P. Two AP1 sites binding JunB are essential for human papillomavirus type 18 transcription in keratinocytes. J Virol. 1992 Jun; 66(6):3740-8. PMID: 1316480.
    Citations: 57     Fields:    Translation:HumansCells
  122. Heck DV, Yee CL, Howley PM, Münger K. Efficiency of binding the retinoblastoma protein correlates with the transforming capacity of the E7 oncoproteins of the human papillomaviruses. Proc Natl Acad Sci U S A. 1992 May 15; 89(10):4442-6. PMID: 1316608.
    Citations: 88     Fields:    Translation:HumansAnimalsCells
  123. Chellappan S, Kraus VB, Kroger B, Munger K, Howley PM, Phelps WC, Nevins JR. Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. Proc Natl Acad Sci U S A. 1992 May 15; 89(10):4549-53. PMID: 1316611.
    Citations: 184     Fields:    Translation: