Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Ralph Weissleder, Ph.D., M.D.

Co-Author

This page shows the publications co-authored by Ralph Weissleder and Rainer Kohler.
Connection Strength

6.445
  1. SMALL MOLECULE IMAGING AGENT FOR MUTANT KRAS G12C. Adv Ther (Weinh). 2021 May; 4(5).
    View in: PubMed
    Score: 0.241
  2. Myeloid Cell-Targeted Nanocarriers Efficiently Inhibit Cellular Inhibitor of Apoptosis for Cancer Immunotherapy. Cell Chem Biol. 2020 01 16; 27(1):94-104.e5.
    View in: PubMed
    Score: 0.222
  3. Imaging of Tie2 with a Fluorescently Labeled Small Molecule Affinity Ligand. ACS Chem Biol. 2020 01 17; 15(1):151-157.
    View in: PubMed
    Score: 0.221
  4. A Supramolecular Nanocarrier for Delivery of Amiodarone Anti-Arrhythmic Therapy to the Heart. Bioconjug Chem. 2019 03 20; 30(3):733-740.
    View in: PubMed
    Score: 0.208
  5. Modular Nanoparticulate Prodrug Design Enables Efficient Treatment of Solid Tumors Using Bioorthogonal Activation. ACS Nano. 2018 12 26; 12(12):12814-12826.
    View in: PubMed
    Score: 0.207
  6. Arg1 expression defines immunosuppressive subsets of tumor-associated macrophages. Theranostics. 2018; 8(21):5842-5854.
    View in: PubMed
    Score: 0.205
  7. TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy. Nat Biomed Eng. 2018 08; 2(8):578-588.
    View in: PubMed
    Score: 0.199
  8. TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy. Nat Biomed Eng. 2018; 2:578-588.
    View in: PubMed
    Score: 0.199
  9. Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease. Chem Commun (Camb). 2017 Dec 19; 54(1):42-45.
    View in: PubMed
    Score: 0.193
  10. IRF3 and type I interferons fuel a fatal response to myocardial infarction. Nat Med. 2017 Dec; 23(12):1481-1487.
    View in: PubMed
    Score: 0.191
  11. Nano-palladium is a cellular catalyst for in vivo chemistry. Nat Commun. 2017 07 12; 8:15906.
    View in: PubMed
    Score: 0.187
  12. Radiation therapy primes tumors for nanotherapeutic delivery via macrophage-mediated vascular bursts. Sci Transl Med. 2017 05 31; 9(392).
    View in: PubMed
    Score: 0.186
  13. Design and Development of Fluorescent Vemurafenib Analogs for In Vivo Imaging. Theranostics. 2017; 7(5):1257-1265.
    View in: PubMed
    Score: 0.183
  14. Fluorescent vinblastine probes for live cell imaging. Chem Commun (Camb). 2016 Aug 02; 52(64):9953-6.
    View in: PubMed
    Score: 0.175
  15. Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle. Sci Transl Med. 2015 Nov 18; 7(314):314ra183.
    View in: PubMed
    Score: 0.167
  16. Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug. Nat Commun. 2015 Oct 27; 6:8692.
    View in: PubMed
    Score: 0.166
  17. Optimized Near-IR Fluorescent Agents for in Vivo Imaging of Btk Expression. Bioconjug Chem. 2015 Aug 19; 26(8):1513-8.
    View in: PubMed
    Score: 0.162
  18. Single cell resolution in vivo imaging of DNA damage following PARP inhibition. Sci Rep. 2015 May 18; 5:10129.
    View in: PubMed
    Score: 0.161
  19. Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin. Sci Transl Med. 2014 Nov 05; 6(261):261ra152.
    View in: PubMed
    Score: 0.155
  20. Ultrafluorogenic coumarin-tetrazine probes for real-time biological imaging. Angew Chem Int Ed Engl. 2014 Jul 14; 53(29):7531-4.
    View in: PubMed
    Score: 0.151
  21. In vivo imaging of multidrug resistance using a third generation MDR1 inhibitor. Bioconjug Chem. 2014 Jun 18; 25(6):1137-42.
    View in: PubMed
    Score: 0.150
  22. Single cell imaging of Bruton's tyrosine kinase using an irreversible inhibitor. Sci Rep. 2014 Apr 24; 4:4782.
    View in: PubMed
    Score: 0.150
  23. Effect of small-molecule modification on single-cell pharmacokinetics of PARP inhibitors. . 2014 Apr; 13(4):986-95.
    View in: PubMed
    Score: 0.148
  24. Platinum compounds for high-resolution in vivo cancer imaging. ChemMedChem. 2014 Jun; 9(6):1131-5.
    View in: PubMed
    Score: 0.148
  25. A photoactivatable drug-caged fluorophore conjugate allows direct quantification of intracellular drug transport. Chem Commun (Camb). 2013 Dec 07; 49(94):11050-11052.
    View in: PubMed
    Score: 0.146
  26. Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo. Nat Commun. 2013; 4:1504.
    View in: PubMed
    Score: 0.137
  27. Dual imaging and photoactivated nanoprobe for controlled cell tracking. Small. 2013 Jan 28; 9(2):222-7.
    View in: PubMed
    Score: 0.134
  28. Imaging therapeutic PARP inhibition in vivo through bioorthogonally developed companion imaging agents. Neoplasia. 2012 Mar; 14(3):169-77.
    View in: PubMed
    Score: 0.129
  29. Accurate measurement of pancreatic islet beta-cell mass using a second-generation fluorescent exendin-4 analog. Proc Natl Acad Sci U S A. 2011 Aug 02; 108(31):12815-20.
    View in: PubMed
    Score: 0.124
  30. Near-infrared fluorescent probe for imaging of pancreatic beta cells. Bioconjug Chem. 2010 Jul 21; 21(7):1362-8.
    View in: PubMed
    Score: 0.115
  31. Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease. Circulation. 2009 Apr 07; 119(13):1785-94.
    View in: PubMed
    Score: 0.105
  32. Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo. Circulation. 2007 Dec 11; 116(24):2841-50.
    View in: PubMed
    Score: 0.096
  33. Optical visualization of cathepsin K activity in atherosclerosis with a novel, protease-activatable fluorescence sensor. Circulation. 2007 May 01; 115(17):2292-8.
    View in: PubMed
    Score: 0.092
  34. Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy. Sci Immunol. 2021 Jul 02; 6(61).
    View in: PubMed
    Score: 0.062
  35. Therapeutically reprogrammed nutrient signalling enhances nanoparticulate albumin bound drug uptake and efficacy in KRAS-mutant cancer. Nat Nanotechnol. 2021 07; 16(7):830-839.
    View in: PubMed
    Score: 0.061
  36. Detecting Immune Response to Therapies Targeting PDL1 and BRAF by Using Ferumoxytol MRI and Macrin in Anaplastic Thyroid Cancer. Radiology. 2021 01; 298(1):123-132.
    View in: PubMed
    Score: 0.059
  37. Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells. Cell Syst. 2020 11 18; 11(5):478-494.e9.
    View in: PubMed
    Score: 0.059
  38. In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells. Nat Commun. 2020 07 14; 11(1):3521.
    View in: PubMed
    Score: 0.058
  39. Efficient blockade of locally reciprocated tumor-macrophage signaling using a TAM-avid nanotherapy. Sci Adv. 2020 May; 6(21):eaaz8521.
    View in: PubMed
    Score: 0.057
  40. LTX-315 sequentially promotes lymphocyte-independent and lymphocyte-dependent antitumor effects. Cell Stress. 2019 Oct 14; 3(11):348-360.
    View in: PubMed
    Score: 0.055
  41. Quantitative Imaging of Tumor-Associated Macrophages and Their Response to Therapy Using 64Cu-Labeled Macrin. ACS Nano. 2018 12 26; 12(12):12015-12029.
    View in: PubMed
    Score: 0.052
  42. Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-? and IL-12. Immunity. 2018 12 18; 49(6):1148-1161.e7.
    View in: PubMed
    Score: 0.052
  43. Imaging the emergence and natural progression of spontaneous autoimmune diabetes. Proc Natl Acad Sci U S A. 2017 09 12; 114(37):E7776-E7785.
    View in: PubMed
    Score: 0.047
  44. In vivo imaging reveals a tumor-associated macrophage-mediated resistance pathway in anti-PD-1 therapy. Sci Transl Med. 2017 05 10; 9(389).
    View in: PubMed
    Score: 0.046
  45. In vivo cell-cycle profiling in xenograft tumors by quantitative intravital microscopy. Nat Methods. 2015 Jun; 12(6):577-85.
    View in: PubMed
    Score: 0.040
  46. Population dynamics of islet-infiltrating cells in autoimmune diabetes. Proc Natl Acad Sci U S A. 2015 Feb 03; 112(5):1511-6.
    View in: PubMed
    Score: 0.039
  47. Angiotensin II drives the production of tumor-promoting macrophages. Immunity. 2013 Feb 21; 38(2):296-308.
    View in: PubMed
    Score: 0.034
  48. Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics. Cancer Res. 2011 Jul 01; 71(13):4608-16.
    View in: PubMed
    Score: 0.031
  49. Pioglitazone suppresses inflammation in vivo in murine carotid atherosclerosis: novel detection by dual-target fluorescence molecular imaging. Arterioscler Thromb Vasc Biol. 2010 Oct; 30(10):1933-9.
    View in: PubMed
    Score: 0.029
  50. Intravital molecular imaging of small-diameter tissue-engineered vascular grafts in mice: a feasibility study. Tissue Eng Part C Methods. 2010 Aug; 16(4):597-607.
    View in: PubMed
    Score: 0.029
  51. Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation. Eur Heart J. 2010 Aug; 31(16):1975-84.
    View in: PubMed
    Score: 0.029
  52. Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science. 2009 Jul 31; 325(5940):612-6.
    View in: PubMed
    Score: 0.027
  53. The antiproliferative cytostatic effects of a self-activating viridin prodrug. . 2009 Jun; 8(6):1666-75.
    View in: PubMed
    Score: 0.027
  54. Behavior of endogenous tumor-associated macrophages assessed in vivo using a functionalized nanoparticle. Neoplasia. 2009 May; 11(5):459-68, 2 p following 468.
    View in: PubMed
    Score: 0.027
  55. Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation. J Clin Invest. 2008 Dec; 118(12):4058-66.
    View in: PubMed
    Score: 0.026
  56. Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth. PLoS One. 2008 Aug 13; 3(8):e2916.
    View in: PubMed
    Score: 0.025
  57. Detection of macrophage activity in atherosclerosis in vivo using multichannel, high-resolution laser scanning fluorescence microscopy. J Biomed Opt. 2006 Mar-Apr; 11(2):021009.
    View in: PubMed
    Score: 0.021
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.