Harvard Catalyst Profiles

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Bruce A. Yankner, M.D.,Ph.D.

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Mentoring
Available: 12/01/18, Expires: 12/01/21

The major risk factor for Alzheimer’s disease (AD) is the aging of the brain. However, the mechanisms at work in the aging brain that lead to AD are unclear. Our laboratory has defined the transcriptome of the human brain during aging on a genome-wide scale. This has led to the identification of age-related gene expression changes in the brain that distinguish normal aging from cognitive decline, including genes involved in synaptic function, learning and memory. We have now identified a central regulatory pathway of age-related gene expression in the brain that is dysregulated in AD.
Projects fall into three categories:
1. Model systems such as C. elegans and neurons in culture that recapitulate aspects of brain aging and AD enabling the in depth study of molecular and cellular mechanisms.
2. Genetically engineered mouse models that recapitulate human AD pathology and the aging process, and
3. Genetic and bioinformatic studies of the human brain in thousands of subjects followed longitudinally with neurological evaluations and memory testing.
Projects for students can be arranged in each of these areas, depending on the interest and background of the student.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01MH113279 (YANKNER, BRUCE A) Sep 26, 2016 - Jun 30, 2021
    NIH/NIMH
    Exploring a Novel Paradigm of Schizophrenia and Bipolar Disorder
    Role: Co-Principal Investigator
  2. R01AG046174 (YANKNER, BRUCE A) Sep 15, 2014 - May 31, 2019
    NIH/NIA
    Targeting a Novel Regulator of Brain Aging and Alzheimer's Disease
    Role: Co-Principal Investigator
  3. RF1AG048056 (YANKNER, BRUCE A) Aug 15, 2014 - Jun 30, 2019
    NIH/NIA
    Genome Engineering an IPSC Model of Alzheimer's Disease
    Role: Co-Principal Investigator
  4. DP1AG044161 (YANKNER, BRUCE A) Sep 30, 2010 - Jul 31, 2015
    NIH/NIA
    Modeling the Aging Epigenome
    Role: Principal Investigator
  5. DP1OD006849 (YANKNER, BRUCE A) Sep 30, 2010 - Jul 31, 2015
    NIH
    Modeling the Aging Epigenome
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Meyer K, Feldman HM, Lu T, Drake D, Lim ET, Ling KH, Bishop NA, Pan Y, Seo J, Lin YT, Su SC, Church GM, Tsai LH, Yankner BA. REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer's Disease. Cell Rep. 2019 Jan 29; 26(5):1112-1127.e9. PMID: 30699343.
    Citations:    Fields:    
  2. Xu D, Jin T, Zhu H, Chen H, Ofengeim D, Zou C, Mifflin L, Pan L, Amin P, Li W, Shan B, Naito MG, Meng H, Li Y, Pan H, Aron L, Adiconis X, Levin JZ, Yankner BA, Yuan J. TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging. Cell. 2018 Sep 06; 174(6):1477-1491.e19. PMID: 30146158.
    Citations: 1     Fields:    
  3. Lin YT, Seo J, Gao F, Feldman HM, Wen HL, Penney J, Cam HP, Gjoneska E, Raja WK, Cheng J, Rueda R, Kritskiy O, Abdurrob F, Peng Z, Milo B, Yu CJ, Elmsaouri S, Dey D, Ko T, Yankner BA, Tsai LH. APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types. Neuron. 2018 Jun 27; 98(6):1294. PMID: 29953873.
    Citations:    Fields:    
  4. Lin YT, Seo J, Gao F, Feldman HM, Wen HL, Penney J, Cam HP, Gjoneska E, Raja WK, Cheng J, Rueda R, Kritskiy O, Abdurrob F, Peng Z, Milo B, Yu CJ, Elmsaouri S, Dey D, Ko T, Yankner BA, Tsai LH. APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types. Neuron. 2018 Jun 27; 98(6):1141-1154.e7. PMID: 29861287.
    Citations: 3     Fields:    
  5. Meyer K, Yankner BA. Slowing Down Aging. Cell Metab. 2017 Oct 03; 26(4):592-593. PMID: 28978424.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  6. Aron L, Yankner BA. Neurodegenerative disorders: Neural synchronization in Alzheimer's disease. Nature. 2016 12 07; 540(7632):207-208. PMID: 27929001.
    Citations: 2     Fields:    Translation:Humans
  7. Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, Yang TH, Kim HM, Drake D, Liu XS, Bennett DA, Colaiácovo MP, Yankner BA. Addendum: REST and stress resistance in ageing and Alzheimer's disease. Nature. 2016 12 15; 540(7633):470. PMID: 27851730.
    Citations: 1     Fields:    
  8. Wolfe MS, Yankner BA. Sorting Out Presenilins in Alzheimer's Disease. Cell. 2016 Jun 30; 166(1):13-5. PMID: 27368096.
    Citations: 2     Fields:    Translation:Humans
  9. Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ. The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. Science. 2015 Sep 25; 349(6255):aaa5612. PMID: 26404840; PMCID: PMC4942138.
    Citations: 88     Fields:    Translation:HumansAnimalsCells
  10. Yankner BA. REST and Alzheimer disease. Ann Neurol. 2015 Sep; 78(3):499. PMID: 25895068.
    Citations: 3     Fields:    Translation:Humans
  11. Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, Yang TH, Kim HM, Drake D, Liu XS, Bennett DA, Colaiácovo MP, Yankner BA. REST and stress resistance in ageing and Alzheimer's disease. Nature. 2014 Mar 27; 507(7493):448-54. PMID: 24670762.
    Citations: 140     Fields:    Translation:HumansAnimalsCells
  12. Mosammaparast N, Kim H, Laurent B, Zhao Y, Lim HJ, Majid MC, Dango S, Luo Y, Hempel K, Sowa ME, Gygi SP, Steen H, Harper JW, Yankner B, Shi Y. The histone demethylase LSD1/KDM1A promotes the DNA damage response. J Cell Biol. 2013 Nov 11; 203(3):457-70. PMID: 24217620; PMCID: PMC3824007.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  13. Gabuzda D, Yankner BA. Physiology: Inflammation links ageing to the brain. Nature. 2013 May 09; 497(7448):197-8. PMID: 23636321; PMCID: PMC3860882.
    Citations: 9     Fields:    Translation:Animals
  14. Lee PC, Dodart JC, Aron L, Finley LW, Bronson RT, Haigis MC, Yankner BA, Harper JW. Altered social behavior and neuronal development in mice lacking the Uba6-Use1 ubiquitin transfer system. Mol Cell. 2013 Apr 25; 50(2):172-84. PMID: 23499007; PMCID: PMC3640669.
    Citations: 8     Fields:    Translation:AnimalsCells
  15. Sun F, Park KK, Belin S, Wang D, Lu T, Chen G, Zhang K, Yeung C, Feng G, Yankner BA, He Z. Sustained axon regeneration induced by co-deletion of PTEN and SOCS3. Nature. 2011 Nov 06; 480(7377):372-5. PMID: 22056987; PMCID: PMC3240702.
    Citations: 191     Fields:    Translation:AnimalsCells
  16. Haigis MC, Yankner BA. The aging stress response. Mol Cell. 2010 Oct 22; 40(2):333-44. PMID: 20965426; PMCID: PMC2987618.
    Citations: 132     Fields:    Translation:HumansAnimalsCells
  17. Lipinski MM, Zheng B, Lu T, Yan Z, Py BF, Ng A, Xavier RJ, Li C, Yankner BA, Scherzer CR, Yuan J. Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14164-9. PMID: 20660724; PMCID: PMC2922576.
    Citations: 137     Fields:    Translation:HumansCells
  18. Furuya T, Kim M, Lipinski M, Li J, Kim D, Lu T, Shen Y, Rameh L, Yankner B, Tsai LH, Yuan J. Negative regulation of Vps34 by Cdk mediated phosphorylation. Mol Cell. 2010 May 28; 38(4):500-11. PMID: 20513426; PMCID: PMC2888511.
    Citations: 50     Fields:    Translation:HumansCells
  19. Bishop NA, Lu T, Yankner BA. Neural mechanisms of ageing and cognitive decline. Nature. 2010 Mar 25; 464(7288):529-35. PMID: 20336135.
    Citations: 256     Fields:    Translation:HumansAnimalsCells
  20. Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, Hartlerode A, Stegmuller J, Hafner A, Loerch P, Wright SM, Mills KD, Bonni A, Yankner BA, Scully R, Prolla TA, Alt FW, Sinclair DA. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell. 2008 Nov 28; 135(5):907-18. PMID: 19041753; PMCID: PMC2853975.
    Citations: 290     Fields:    Translation:HumansAnimalsCells
  21. Yankner BA, Lu T. Amyloid beta-protein toxicity and the pathogenesis of Alzheimer disease. J Biol Chem. 2009 Feb 20; 284(8):4755-9. PMID: 18957434; PMCID: PMC2643502.
    Citations: 61     Fields:    Translation:HumansAnimals
  22. Loerch PM, Lu T, Dakin KA, Vann JM, Isaacs A, Geula C, Wang J, Pan Y, Gabuzda DH, Li C, Prolla TA, Yankner BA. Evolution of the aging brain transcriptome and synaptic regulation. PLoS One. 2008 Oct 02; 3(10):e3329. PMID: 18830410; PMCID: PMC2553198.
    Citations: 96     Fields:    Translation:HumansAnimalsCells
  23. Papadia S, Soriano FX, Léveillé F, Martel MA, Dakin KA, Hansen HH, Kaindl A, Sifringer M, Fowler J, Stefovska V, McKenzie G, Craigon M, Corriveau R, Ghazal P, Horsburgh K, Yankner BA, Wyllie DJ, Ikonomidou C, Hardingham GE. Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses. Nat Neurosci. 2008 Apr; 11(4):476-87. PMID: 18344994.
    Citations: 196     Fields:    Translation:AnimalsCells
  24. Yankner BA, Lu T, Loerch P. The aging brain. Annu Rev Pathol. 2008; 3:41-66. PMID: 18039130.
    Citations: 170     Fields:    Translation:HumansAnimals
  25. Isaacs AM, Senn DB, Yuan M, Shine JP, Yankner BA. Acceleration of amyloid beta-peptide aggregation by physiological concentrations of calcium. J Biol Chem. 2006 Sep 22; 281(38):27916-23. PMID: 16870617; PMCID: PMC1595535.
    Citations: 28     Fields:    Translation:AnimalsCells
  26. Shibata M, Lu T, Furuya T, Degterev A, Mizushima N, Yoshimori T, MacDonald M, Yankner B, Yuan J. Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J Biol Chem. 2006 May 19; 281(20):14474-85. PMID: 16522639.
    Citations: 152     Fields:    Translation:HumansAnimals
  27. Hass MR, Yankner BA. A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein. J Biol Chem. 2005 Nov 04; 280(44):36895-904. PMID: 16103124; PMCID: PMC1562327.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  28. Xu J, Zhong N, Wang H, Elias JE, Kim CY, Woldman I, Pifl C, Gygi SP, Geula C, Yankner BA. The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis. Hum Mol Genet. 2005 May 01; 14(9):1231-41. PMID: 15790595.
    Citations: 72     Fields:    Translation:HumansCells
  29. Lu T, Pan Y, Kao SY, Li C, Kohane I, Chan J, Yankner BA. Gene regulation and DNA damage in the ageing human brain. Nature. 2004 Jun 24; 429(6994):883-91. PMID: 15190254.
    Citations: 515     Fields:    Translation:HumansCells
  30. Chen F, Tandon A, Sanjo N, Gu YJ, Hasegawa H, Arawaka S, Lee FJ, Ruan X, Mastrangelo P, Erdebil S, Wang L, Westaway D, Mount HT, Yankner B, Fraser PE, St George-Hyslop P. Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain. J Biol Chem. 2003 May 30; 278(22):19974-9. PMID: 12646573.
    Citations: 8     Fields:    Translation:Animals
  31. Xu J, Kao SY, Lee FJ, Song W, Jin LW, Yankner BA. Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease. Nat Med. 2002 Jun; 8(6):600-6. PMID: 12042811.
    Citations: 184     Fields:    Translation:HumansCells
  32. Ebinu JO, Yankner BA. A RIP tide in neuronal signal transduction. Neuron. 2002 May 16; 34(4):499-502. PMID: 12062033.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  33. Busciglio J, Pelsman A, Wong C, Pigino G, Yuan M, Mori H, Yankner BA. Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome. Neuron. 2002 Feb 28; 33(5):677-88. PMID: 11879646.
    Citations: 80     Fields:    Translation:HumansCells
  34. Weninger SC, Yankner BA. Inflammation and Alzheimer disease: the good, the bad, and the ugly. Nat Med. 2001 May; 7(5):527-8. PMID: 11329045.
    Citations: 14     Fields:    Translation:HumansAnimals
  35. Yuan J, Yankner BA. Apoptosis in the nervous system. Nature. 2000 Oct 12; 407(6805):802-9. PMID: 11048732.
    Citations: 389     Fields:    Translation:HumansAnimalsCells
  36. Zhang Z, Nadeau P, Song W, Donoviel D, Yuan M, Bernstein A, Yankner BA. Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1. Nat Cell Biol. 2000 Jul; 2(7):463-5. PMID: 10878814.
    Citations: 77     Fields:    Translation:AnimalsCells
  37. Lorenzo A, Yuan M, Zhang Z, Paganetti PA, Sturchler-Pierrat C, Staufenbiel M, Mautino J, Vigo FS, Sommer B, Yankner BA. Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease. Nat Neurosci. 2000 May; 3(5):460-4. PMID: 10769385.
    Citations: 81     Fields:    Translation:AnimalsCells
  38. Yankner BA. A century of cognitive decline. Nature. 2000 Mar 09; 404(6774):125. PMID: 10724145.
    Citations: 7     Fields:    Translation:HumansCells
  39. Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature. 2000 Jan 06; 403(6765):98-103. PMID: 10638761.
    Citations: 736     Fields:    Translation:HumansAnimalsCells
  40. Yankner BA. The pathogenesis of Alzheimer's disease. Is amyloid beta-protein the beginning or the end? Ann N Y Acad Sci. 2000; 924:26-8. PMID: 11193797.
    Citations: 10     Fields:    Translation:Humans
  41. Hartmann H, Yankner BA. Normal proteolytic processing of the presenilins. Methods Mol Med. 2000; 32:297-308. PMID: 21318527.
    Citations:    Fields:    
  42. Song W, Nadeau P, Yuan M, Yang X, Shen J, Yankner BA. Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations. Proc Natl Acad Sci U S A. 1999 Jun 08; 96(12):6959-63. PMID: 10359821; PMCID: PMC22024.
    Citations: 85     Fields:    Translation:AnimalsCells
  43. Yuan J, Yankner BA. Caspase activity sows the seeds of neuronal death. Nat Cell Biol. 1999 Jun; 1(2):E44-5. PMID: 10559896.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  44. Liu C, Kato Y, Zhang Z, Do VM, Yankner BA, He X. beta-Trcp couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formation. Proc Natl Acad Sci U S A. 1999 May 25; 96(11):6273-8. PMID: 10339577; PMCID: PMC26871.
    Citations: 120     Fields:    Translation:HumansAnimalsCells
  45. Zhang Z, Hartmann H, Do VM, Abramowski D, Sturchler-Pierrat C, Staufenbiel M, Sommer B, van de Wetering M, Clevers H, Saftig P, De Strooper B, He X, Yankner BA. Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature. 1998 Oct 15; 395(6703):698-702. PMID: 9790190.
    Citations: 125     Fields:    Translation:HumansAnimalsCells
  46. Geula C, Wu CK, Saroff D, Lorenzo A, Yuan M, Yankner BA. Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity. Nat Med. 1998 Jul; 4(7):827-31. PMID: 9662375.
    Citations: 80     Fields:    Translation:AnimalsCells
  47. Yankner BA. Monster plaques: what they tell us about Alzheimer's disease. Nat Med. 1998 Apr; 4(4):394-5. PMID: 9546781.
    Citations:    Fields:    Translation:HumansCells
  48. Busciglio J, Hartmann H, Lorenzo A, Wong C, Baumann K, Sommer B, Staufenbiel M, Yankner BA. Neuronal localization of presenilin-1 and association with amyloid plaques and neurofibrillary tangles in Alzheimer's disease. J Neurosci. 1997 Jul 01; 17(13):5101-7. PMID: 9185547.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  49. Hartmann H, Busciglio J, Baumann KH, Staufenbiel M, Yankner BA. Developmental regulation of presenilin-1 processing in the brain suggests a role in neuronal differentiation. J Biol Chem. 1997 Jun 06; 272(23):14505-8. PMID: 9169406.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  50. Baumann K, Paganetti PA, Sturchler-Pierrat C, Wong C, Hartmann H, Cescato R, Frey P, Yankner BA, Sommer B, Staufenbiel M. Distinct processing of endogenous and overexpressed recombinant presenilin 1. Neurobiol Aging. 1997 Mar-Apr; 18(2):181-9. PMID: 9258895.
    Citations: 4     Fields:    Translation:HumansCells
  51. Yankner BA. New clues to Alzheimer's disease: unraveling the roles of amyloid and tau. Nat Med. 1996 Aug; 2(8):850-2. PMID: 8705846.
    Citations: 15     Fields:    Translation:HumansAnimals
  52. Yankner BA. Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron. 1996 May; 16(5):921-32. PMID: 8630250.
    Citations: 136     Fields:    Translation:HumansAnimalsCells
  53. Lorenzo A, Yankner BA. Amyloid fibril toxicity in Alzheimer's disease and diabetes. Ann N Y Acad Sci. 1996 Jan 17; 777:89-95. PMID: 8624132.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  54. Busciglio J, Yankner BA. Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature. 1995 Dec 21-28; 378(6559):776-9. PMID: 8524410.
    Citations: 114     Fields:    Translation:HumansCells
  55. Martin BL, Schrader-Fischer G, Busciglio J, Duke M, Paganetti P, Yankner BA. Intracellular accumulation of beta-amyloid in cells expressing the Swedish mutant amyloid precursor protein. J Biol Chem. 1995 Nov 10; 270(45):26727-30. PMID: 7592902.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  56. Busciglio J, Lorenzo A, Yeh J, Yankner BA. beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding. Neuron. 1995 Apr; 14(4):879-88. PMID: 7718249.
    Citations: 124     Fields:    Translation:HumansAnimalsCells
  57. Lorenzo A, Yankner BA. Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red. Proc Natl Acad Sci U S A. 1994 Dec 06; 91(25):12243-7. PMID: 7991613; PMCID: PMC45413.
    Citations: 188     Fields:    Translation:AnimalsCells
  58. Gabuzda D, Busciglio J, Chen LB, Matsudaira P, Yankner BA. Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative. J Biol Chem. 1994 May 06; 269(18):13623-8. PMID: 8175797.
    Citations: 60     Fields:    Translation:HumansCells
  59. Lorenzo A, Razzaboni B, Weir GC, Yankner BA. Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus. Nature. 1994 Apr 21; 368(6473):756-60. PMID: 8152488.
    Citations: 181     Fields:    Translation:HumansAnimalsCells
  60. Gabuzda D, Busciglio J, Yankner BA. Inhibition of beta-amyloid production by activation of protein kinase C. J Neurochem. 1993 Dec; 61(6):2326-9. PMID: 8245986.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  61. Busciglio J, Yeh J, Yankner BA. beta-Amyloid neurotoxicity in human cortical culture is not mediated by excitotoxins. J Neurochem. 1993 Oct; 61(4):1565-8. PMID: 8377009.
    Citations: 16     Fields:    Translation:HumansCells
  62. Busciglio J, Gabuzda DH, Matsudaira P, Yankner BA. Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells. Proc Natl Acad Sci U S A. 1993 Mar 01; 90(5):2092-6. PMID: 8446635; PMCID: PMC46027.
    Citations: 93     Fields:    Translation:AnimalsCells
  63. Yankner BA. Commentary and perspective on studies of beta amyloid neurotoxicity. Neurobiol Aging. 1992 Sep-Oct; 13(5):615-6. PMID: 1461352.
    Citations: 9     Fields:    Translation:HumansAnimals
  64. Busciglio J, Lorenzo A, Yankner BA. Methodological variables in the assessment of beta amyloid neurotoxicity. Neurobiol Aging. 1992 Sep-Oct; 13(5):609-12. PMID: 1461350.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  65. Kowall NW, McKee AC, Yankner BA, Beal MF. In vivo neurotoxicity of beta-amyloid [beta(1-40)] and the beta(25-35) fragment. Neurobiol Aging. 1992 Sep-Oct; 13(5):537-42. PMID: 1461341.
    Citations: 33     Fields:    Translation:AnimalsCells
  66. Chen M, Tempst P, Yankner BA. Secretogranin I/chromogranin B is a heparin-binding adhesive protein. J Neurochem. 1992 May; 58(5):1691-8. PMID: 1560226.
    Citations: 4     Fields:    Translation:AnimalsCells
  67. Yankner BA, Mesulam MM. Seminars in medicine of the Beth Israel Hospital, Boston. beta-Amyloid and the pathogenesis of Alzheimer's disease. N Engl J Med. 1991 Dec 26; 325(26):1849-57. PMID: 1961223.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  68. Kowall NW, Beal MF, Busciglio J, Duffy LK, Yankner BA. An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P. Proc Natl Acad Sci U S A. 1991 Aug 15; 88(16):7247-51. PMID: 1714596; PMCID: PMC52271.
    Citations: 75     Fields:    Translation:AnimalsCells
  69. Chen M, Yankner BA. An antibody to beta amyloid and the amyloid precursor protein inhibits cell-substratum adhesion in many mammalian cell types. Neurosci Lett. 1991 Apr 29; 125(2):223-6. PMID: 1715534.
    Citations: 17     Fields:    Translation:AnimalsCells
  70. Yankner BA, Caceres A, Duffy LK. Nerve growth factor potentiates the neurotoxicity of beta amyloid. Proc Natl Acad Sci U S A. 1990 Nov; 87(22):9020-3. PMID: 2174172; PMCID: PMC55092.
    Citations: 28     Fields:    Translation:AnimalsCells
  71. Yankner BA, Duffy LK, Kirschner DA. Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. Science. 1990 Oct 12; 250(4978):279-82. PMID: 2218531.
    Citations: 319     Fields:    Translation:AnimalsCells
  72. Neve RL, Dawes LR, Yankner BA, Benowitz LI, Rodriguez W, Higgins GA. Genetics and biology of the Alzheimer amyloid precursor. Prog Brain Res. 1990; 86:257-67. PMID: 2150887.
    Citations: 15     Fields:    Translation:HumansCells
  73. Yankner BA, Benowitz LI, Villa-Komaroff L, Neve RL. Transfection of PC12 cells with the human GAP-43 gene: effects on neurite outgrowth and regeneration. Brain Res Mol Brain Res. 1990 Jan; 7(1):39-44. PMID: 2153893.
    Citations: 31     Fields:    Translation:HumansCells
  74. Yankner BA. NGF and Alzheimer's disease--considerations and caveats. Neurobiol Aging. 1989 Sep-Oct; 10(5):546-7; discussion 552-3. PMID: 2812225.
    Citations:    Fields:    Translation:Humans
  75. Yankner BA. Amyloid and Alzheimer's disease--cause or effect? Neurobiol Aging. 1989 Sep-Oct; 10(5):470-1; discussion 477-8. PMID: 2682324.
    Citations: 7     Fields:    Translation:Humans
  76. Yankner BA, Dawes LR, Fisher S, Villa-Komaroff L, Oster-Granite ML, Neve RL. Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. Science. 1989 Jul 28; 245(4916):417-20. PMID: 2474201.
    Citations: 159     Fields:    Translation:HumansCells
  77. Yankner BA, Skolnik PR, Shoukimas GM, Gabuzda DH, Sobel RA, Ho DD. Cerebral granulomatous angiitis associated with isolation of human T-lymphotropic virus type III from the central nervous system. Ann Neurol. 1986 Sep; 20(3):362-4. PMID: 3639720.
    Citations: 14     Fields:    Translation:HumansCells
  78. Yankner BA, Shooter EM. The biology and mechanism of action of nerve growth factor. Annu Rev Biochem. 1982; 51:845-68. PMID: 6287924.
    Citations: 42     Fields:    Translation:Cells
  79. Shooter EM, Yankner BA, Landreth GE, Sutter A. Biosynthesis and mechanism of action of nerve growth factor. Recent Prog Horm Res. 1981; 37:417-46. PMID: 6269164.
    Citations: 7     Fields:    Translation:AnimalsCells
  80. Yankner BA, Shooter EM. Nerve growth factor in the nucleus: interaction with receptors on the nuclear membrane. Proc Natl Acad Sci U S A. 1979 Mar; 76(3):1269-73. PMID: 286309; PMCID: PMC383232.
    Citations: 39     Fields:    Translation:AnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.