Bruce A. Yankner, M.D.,Ph.D.
|Title||Professor of Genetics|
|Institution||Harvard Medical School|
|Address||Harvard Medical School|
Dept. of Genetics, NRB-858C
77 Avenue Louis Pasteur
Boston MA 02115
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|Title||Professor of Neurology|
|Institution||Boston Children's Hospital|
Available: 05/01/15, Expires: 04/30/18
The major risk factor for Alzheimer’s disease (AD) is the aging of the brain. However, the mechanisms at work in the aging brain that lead to AD are unclear. Our laboratory has defined the transcriptome of the human brain during aging on a genome-wide scale. This has led to the identification of age-related gene expression changes in the brain that distinguish normal aging from cognitive decline, including genes involved in synaptic function, learning and memory. We have now identified a central regulatory pathway of age-related gene expression in the brain that is dysregulated in AD.
Projects fall into three categories:
1. Model systems such as C. elegans and neurons in culture that recapitulate aspects of brain aging and AD enabling the in depth study of molecular and cellular mechanisms.
2. Genetically engineered mouse models that recapitulate human AD pathology and the aging process, and
3. Genetic and bioinformatic studies of the human brain in thousands of subjects followed longitudinally with neurological evaluations and memory testing.
Projects for students can be arranged in each of these areas, depending on the interest and background of the student.
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