Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Bruce A. Yankner, M.D.,Ph.D.

Other Positions

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AG069042 (YANKNER, BRUCE A) May 1, 2021 - Apr 30, 2026
    Targeting REST in Alzheimer's Disease
    Role: Principal Investigator
  2. R56AG069042 (YANKNER, BRUCE A) Sep 30, 2020 - Aug 31, 2021
    REST and Neural Network Dysfunction in Alzheimer's Disease
    Role: Principal Investigator
  3. R01MH113279 (YANKNER, BRUCE A) Sep 26, 2016 - Jun 30, 2021
    Exploring a Novel Paradigm of Schizophrenia and Bipolar Disorder
    Role: Co-Principal Investigator
  4. R01AG046174 (YANKNER, BRUCE A) Sep 15, 2014 - May 31, 2020
    Targeting a Novel Regulator of Brain Aging and Alzheimer's Disease
    Role: Co-Principal Investigator
  5. RF1AG048056 (YANKNER, BRUCE A) Aug 15, 2014 - Jun 30, 2019
    Genome Engineering an IPSC Model of Alzheimer's Disease
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lim ET, Chan Y, Dawes P, Guo X, Erdin S, Tai DJC, Liu S, Reichert JM, Burns MJ, Chan YK, Chiang JJ, Meyer K, Zhang X, Walsh CA, Yankner BA, Raychaudhuri S, Hirschhorn JN, Gusella JF, Talkowski ME, Church GM. Orgo-Seq integrates single-cell and bulk transcriptomic data to identify cell type specific-driver genes associated with autism spectrum disorder. Nat Commun. 2022 06 10; 13(1):3243. PMID: 35688811; PMCID: PMC9187732.
    Citations:    Fields:    Translation:HumansCells
  2. Xia Y, Qadota H, Wang ZH, Liu P, Liu X, Ye KX, Matheny CJ, Berglund K, Yu SP, Drake D, Bennett DA, Wang XC, Yankner BA, Benian GM, Ye K. Neuronal C/EBPß/AEP pathway shortens life span via selective GABAnergic neuronal degeneration by FOXO repression. Sci Adv. 2022 04; 8(13):eabj8658. PMID: 35353567; PMCID: PMC8967231.
    Citations: 1     Fields:    Translation:AnimalsCells
  3. Aron L, Zullo J, Yankner BA. The adaptive aging brain. Curr Opin Neurobiol. 2022 02; 72:91-100. PMID: 34689041; PMCID: PMC8901453.
    Citations: 1     Fields:    Translation:Humans
  4. Liu S, Punthambaker S, Iyer EPR, Ferrante T, Goodwin D, Fürth D, Pawlowski AC, Jindal K, Tam JM, Mifflin L, Alon S, Sinha A, Wassie AT, Chen F, Cheng A, Willocq V, Meyer K, Ling KH, Camplisson CK, Kohman RE, Aach J, Lee JH, Yankner BA, Boyden ES, Church GM. Barcoded oligonucleotides ligated on RNA amplified for multiplexed and parallel in situ analyses. Nucleic Acids Res. 2021 06 04; 49(10):e58. PMID: 33693773.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  5. Magassa S, Aron L, Hoguin C, Isnard P, Terzi F, Legendre C, Yankner BA, Canaud G. REST and Stress Resistance in the Aging Kidney. J Am Soc Nephrol. 2021 08; 32(8):1974-1986. PMID: 34078664; PMCID: PMC8455262.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  6. Zullo JM, Drake D, Aron L, O'Hern P, Dhamne SC, Davidsohn N, Mao CA, Klein WH, Rotenberg A, Bennett DA, Church GM, Colaiácovo MP, Yankner BA. Regulation of lifespan by neural excitation and REST. Nature. 2019 10; 574(7778):359-364. PMID: 31619788; PMCID: PMC6893853.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  7. Meyer K, Feldman HM, Lu T, Drake D, Lim ET, Ling KH, Bishop NA, Pan Y, Seo J, Lin YT, Su SC, Church GM, Tsai LH, Yankner BA. REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer's Disease. Cell Rep. 2019 01 29; 26(5):1112-1127.e9. PMID: 30699343; PMCID: PMC6386196.
    Citations: 67     Fields:    Translation:HumansCells
  8. Xu D, Jin T, Zhu H, Chen H, Ofengeim D, Zou C, Mifflin L, Pan L, Amin P, Li W, Shan B, Naito MG, Meng H, Li Y, Pan H, Aron L, Adiconis X, Levin JZ, Yankner BA, Yuan J. TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging. Cell. 2018 09 06; 174(6):1477-1491.e19. PMID: 30146158; PMCID: PMC6128749.
    Citations: 124     Fields:    Translation:HumansAnimalsCells
  9. Lin YT, Seo J, Gao F, Feldman HM, Wen HL, Penney J, Cam HP, Gjoneska E, Raja WK, Cheng J, Rueda R, Kritskiy O, Abdurrob F, Peng Z, Milo B, Yu CJ, Elmsaouri S, Dey D, Ko T, Yankner BA, Tsai LH. APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types. Neuron. 2018 06 27; 98(6):1294. PMID: 29953873.
    Citations: 51     Fields:    
  10. Lin YT, Seo J, Gao F, Feldman HM, Wen HL, Penney J, Cam HP, Gjoneska E, Raja WK, Cheng J, Rueda R, Kritskiy O, Abdurrob F, Peng Z, Milo B, Yu CJ, Elmsaouri S, Dey D, Ko T, Yankner BA, Tsai LH. APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types. Neuron. 2018 06 27; 98(6):1141-1154.e7. PMID: 29861287.
    Citations: 232     Fields:    Translation:HumansCells
  11. Meyer K, Yankner BA. Slowing Down Aging. Cell Metab. 2017 Oct 03; 26(4):592-593. PMID: 28978424.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  12. Aron L, Yankner BA. Neurodegenerative disorders: Neural synchronization in Alzheimer's disease. Nature. 2016 12 07; 540(7632):207-208. PMID: 27929001.
    Citations: 7     Fields:    Translation:Humans
  13. Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, Yang TH, Kim HM, Drake D, Liu XS, Bennett DA, Colaiácovo MP, Yankner BA. Addendum: REST and stress resistance in ageing and Alzheimer's disease. Nature. 2016 12 15; 540(7633):470. PMID: 27851730.
    Citations: 6     Fields:    
  14. Wolfe MS, Yankner BA. Sorting Out Presenilins in Alzheimer's Disease. Cell. 2016 Jun 30; 166(1):13-5. PMID: 27368096.
    Citations: 5     Fields:    Translation:Humans
  15. Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ. The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. Science. 2015 Sep 25; 349(6255):aaa5612. PMID: 26404840; PMCID: PMC4942138.
    Citations: 304     Fields:    Translation:HumansAnimalsCells
  16. Yankner BA. REST and Alzheimer disease. Ann Neurol. 2015 Sep; 78(3):499. PMID: 25895068.
    Citations: 4     Fields:    Translation:Humans
  17. Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, Yang TH, Kim HM, Drake D, Liu XS, Bennett DA, Colaiácovo MP, Yankner BA. REST and stress resistance in ageing and Alzheimer's disease. Nature. 2014 03 27; 507(7493):448-54. PMID: 24670762.
    Citations: 302     Fields:    Translation:HumansAnimalsCells
  18. Mosammaparast N, Kim H, Laurent B, Zhao Y, Lim HJ, Majid MC, Dango S, Luo Y, Hempel K, Sowa ME, Gygi SP, Steen H, Harper JW, Yankner B, Shi Y. The histone demethylase LSD1/KDM1A promotes the DNA damage response. J Cell Biol. 2013 Nov 11; 203(3):457-70. PMID: 24217620.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  19. Gabuzda D, Yankner BA. Physiology: Inflammation links ageing to the brain. Nature. 2013 May 09; 497(7448):197-8. PMID: 23636321.
    Citations: 27     Fields:    Translation:Animals
  20. Lee PC, Dodart JC, Aron L, Finley LW, Bronson RT, Haigis MC, Yankner BA, Harper JW. Altered social behavior and neuronal development in mice lacking the Uba6-Use1 ubiquitin transfer system. Mol Cell. 2013 Apr 25; 50(2):172-84. PMID: 23499007.
    Citations: 18     Fields:    Translation:AnimalsCells
  21. Sun F, Park KK, Belin S, Wang D, Lu T, Chen G, Zhang K, Yeung C, Feng G, Yankner BA, He Z. Sustained axon regeneration induced by co-deletion of PTEN and SOCS3. Nature. 2011 Nov 06; 480(7377):372-5. PMID: 22056987.
    Citations: 326     Fields:    Translation:AnimalsCells
  22. Haigis MC, Yankner BA. The aging stress response. Mol Cell. 2010 Oct 22; 40(2):333-44. PMID: 20965426.
    Citations: 213     Fields:    Translation:HumansAnimalsCells
  23. Lipinski MM, Zheng B, Lu T, Yan Z, Py BF, Ng A, Xavier RJ, Li C, Yankner BA, Scherzer CR, Yuan J. Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14164-9. PMID: 20660724.
    Citations: 279     Fields:    Translation:HumansCells
  24. Furuya T, Kim M, Lipinski M, Li J, Kim D, Lu T, Shen Y, Rameh L, Yankner B, Tsai LH, Yuan J. Negative regulation of Vps34 by Cdk mediated phosphorylation. Mol Cell. 2010 May 28; 38(4):500-11. PMID: 20513426.
    Citations: 81     Fields:    Translation:HumansCells
  25. Bishop NA, Lu T, Yankner BA. Neural mechanisms of ageing and cognitive decline. Nature. 2010 Mar 25; 464(7288):529-35. PMID: 20336135.
    Citations: 457     Fields:    Translation:HumansAnimalsCells
  26. Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, Hartlerode A, Stegmuller J, Hafner A, Loerch P, Wright SM, Mills KD, Bonni A, Yankner BA, Scully R, Prolla TA, Alt FW, Sinclair DA. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell. 2008 Nov 28; 135(5):907-18. PMID: 19041753.
    Citations: 374     Fields:    Translation:HumansAnimalsCells
  27. Yankner BA, Lu T. Amyloid beta-protein toxicity and the pathogenesis of Alzheimer disease. J Biol Chem. 2009 Feb 20; 284(8):4755-9. PMID: 18957434.
    Citations: 84     Fields:    Translation:HumansAnimals
  28. Loerch PM, Lu T, Dakin KA, Vann JM, Isaacs A, Geula C, Wang J, Pan Y, Gabuzda DH, Li C, Prolla TA, Yankner BA. Evolution of the aging brain transcriptome and synaptic regulation. PLoS One. 2008 Oct 02; 3(10):e3329. PMID: 18830410; PMCID: PMC2553198.
    Citations: 147     Fields:    Translation:HumansAnimalsCells
  29. Papadia S, Soriano FX, Léveillé F, Martel MA, Dakin KA, Hansen HH, Kaindl A, Sifringer M, Fowler J, Stefovska V, McKenzie G, Craigon M, Corriveau R, Ghazal P, Horsburgh K, Yankner BA, Wyllie DJ, Ikonomidou C, Hardingham GE. Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses. Nat Neurosci. 2008 Apr; 11(4):476-87. PMID: 18344994; PMCID: PMC2556874.
    Citations: 258     Fields:    Translation:AnimalsCells
  30. Yankner BA, Lu T, Loerch P. The aging brain. Annu Rev Pathol. 2008; 3:41-66. PMID: 18039130.
    Citations: 251     Fields:    Translation:HumansAnimals
  31. Isaacs AM, Senn DB, Yuan M, Shine JP, Yankner BA. Acceleration of amyloid beta-peptide aggregation by physiological concentrations of calcium. J Biol Chem. 2006 Sep 22; 281(38):27916-23. PMID: 16870617.
    Citations: 37     Fields:    Translation:AnimalsCells
  32. Shibata M, Lu T, Furuya T, Degterev A, Mizushima N, Yoshimori T, MacDonald M, Yankner B, Yuan J. Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J Biol Chem. 2006 May 19; 281(20):14474-85. PMID: 16522639.
    Citations: 215     Fields:    Translation:HumansAnimals
  33. Hass MR, Yankner BA. A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein. J Biol Chem. 2005 Nov 04; 280(44):36895-904. PMID: 16103124.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  34. Xu J, Zhong N, Wang H, Elias JE, Kim CY, Woldman I, Pifl C, Gygi SP, Geula C, Yankner BA. The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis. Hum Mol Genet. 2005 May 01; 14(9):1231-41. PMID: 15790595.
    Citations: 94     Fields:    Translation:HumansCells
  35. Lu T, Pan Y, Kao SY, Li C, Kohane I, Chan J, Yankner BA. Gene regulation and DNA damage in the ageing human brain. Nature. 2004 Jun 24; 429(6994):883-91. PMID: 15190254.
    Citations: 715     Fields:    Translation:HumansCells
  36. Chen F, Tandon A, Sanjo N, Gu YJ, Hasegawa H, Arawaka S, Lee FJ, Ruan X, Mastrangelo P, Erdebil S, Wang L, Westaway D, Mount HT, Yankner B, Fraser PE, St George-Hyslop P. Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain. J Biol Chem. 2003 May 30; 278(22):19974-9. PMID: 12646573.
    Citations: 11     Fields:    Translation:Animals
  37. Xu J, Kao SY, Lee FJ, Song W, Jin LW, Yankner BA. Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease. Nat Med. 2002 Jun; 8(6):600-6. PMID: 12042811.
    Citations: 250     Fields:    Translation:HumansCells
  38. Ebinu JO, Yankner BA. A RIP tide in neuronal signal transduction. Neuron. 2002 May 16; 34(4):499-502. PMID: 12062033.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  39. Busciglio J, Pelsman A, Wong C, Pigino G, Yuan M, Mori H, Yankner BA. Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome. Neuron. 2002 Feb 28; 33(5):677-88. PMID: 11879646.
    Citations: 128     Fields:    Translation:HumansCells
  40. Weninger SC, Yankner BA. Inflammation and Alzheimer disease: the good, the bad, and the ugly. Nat Med. 2001 May; 7(5):527-8. PMID: 11329045.
    Citations: 20     Fields:    Translation:HumansAnimals
  41. Yuan J, Yankner BA. Apoptosis in the nervous system. Nature. 2000 Oct 12; 407(6805):802-9. PMID: 11048732.
    Citations: 501     Fields:    Translation:HumansAnimalsCells
  42. Zhang Z, Nadeau P, Song W, Donoviel D, Yuan M, Bernstein A, Yankner BA. Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1. Nat Cell Biol. 2000 Jul; 2(7):463-5. PMID: 10878814.
    Citations: 104     Fields:    Translation:AnimalsCells
  43. Lorenzo A, Yuan M, Zhang Z, Paganetti PA, Sturchler-Pierrat C, Staufenbiel M, Mautino J, Vigo FS, Sommer B, Yankner BA. Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease. Nat Neurosci. 2000 May; 3(5):460-4. PMID: 10769385.
    Citations: 114     Fields:    Translation:AnimalsCells
  44. Yankner BA. A century of cognitive decline. Nature. 2000 Mar 09; 404(6774):125. PMID: 10724145.
    Citations: 7     Fields:    Translation:HumansCells
  45. Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature. 2000 Jan 06; 403(6765):98-103. PMID: 10638761.
    Citations: 939     Fields:    Translation:HumansAnimalsCells
  46. Yankner BA. The pathogenesis of Alzheimer's disease. Is amyloid beta-protein the beginning or the end? Ann N Y Acad Sci. 2000; 924:26-8. PMID: 11193797.
    Citations: 12     Fields:    Translation:Humans
  47. Hartmann H, Yankner BA. Normal proteolytic processing of the presenilins. Methods Mol Med. 2000; 32:297-308. PMID: 21318527.
    Citations:    Fields:    
  48. Song W, Nadeau P, Yuan M, Yang X, Shen J, Yankner BA. Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations. Proc Natl Acad Sci U S A. 1999 Jun 08; 96(12):6959-63. PMID: 10359821; PMCID: PMC22024.
    Citations: 106     Fields:    Translation:AnimalsCells
  49. Yuan J, Yankner BA. Caspase activity sows the seeds of neuronal death. Nat Cell Biol. 1999 Jun; 1(2):E44-5. PMID: 10559896.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  50. Liu C, Kato Y, Zhang Z, Do VM, Yankner BA, He X. beta-Trcp couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formation. Proc Natl Acad Sci U S A. 1999 May 25; 96(11):6273-8. PMID: 10339577; PMCID: PMC26871.
    Citations: 168     Fields:    Translation:HumansAnimalsCells
  51. Zhang Z, Hartmann H, Do VM, Abramowski D, Sturchler-Pierrat C, Staufenbiel M, Sommer B, van de Wetering M, Clevers H, Saftig P, De Strooper B, He X, Yankner BA. Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature. 1998 Oct 15; 395(6703):698-702. PMID: 9790190.
    Citations: 163     Fields:    Translation:HumansAnimalsCells
  52. Geula C, Wu CK, Saroff D, Lorenzo A, Yuan M, Yankner BA. Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity. Nat Med. 1998 Jul; 4(7):827-31. PMID: 9662375.
    Citations: 121     Fields:    Translation:AnimalsCells
  53. Yankner BA. Monster plaques: what they tell us about Alzheimer's disease. Nat Med. 1998 Apr; 4(4):394-5. PMID: 9546781.
    Citations:    Fields:    Translation:HumansCells
  54. Busciglio J, Hartmann H, Lorenzo A, Wong C, Baumann K, Sommer B, Staufenbiel M, Yankner BA. Neuronal localization of presenilin-1 and association with amyloid plaques and neurofibrillary tangles in Alzheimer's disease. J Neurosci. 1997 Jul 01; 17(13):5101-7. PMID: 9185547; PMCID: PMC6573321.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  55. Hartmann H, Busciglio J, Baumann KH, Staufenbiel M, Yankner BA. Developmental regulation of presenilin-1 processing in the brain suggests a role in neuronal differentiation. J Biol Chem. 1997 Jun 06; 272(23):14505-8. PMID: 9169406.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  56. Baumann K, Paganetti PA, Sturchler-Pierrat C, Wong C, Hartmann H, Cescato R, Frey P, Yankner BA, Sommer B, Staufenbiel M. Distinct processing of endogenous and overexpressed recombinant presenilin 1. Neurobiol Aging. 1997 Mar-Apr; 18(2):181-9. PMID: 9258895.
    Citations: 4     Fields:    Translation:HumansCells
  57. Yankner BA. New clues to Alzheimer's disease: unraveling the roles of amyloid and tau. Nat Med. 1996 Aug; 2(8):850-2. PMID: 8705846.
    Citations: 20     Fields:    Translation:HumansAnimals
  58. Yankner BA. Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron. 1996 May; 16(5):921-32. PMID: 8630250.
    Citations: 189     Fields:    Translation:HumansAnimalsCells
  59. Lorenzo A, Yankner BA. Amyloid fibril toxicity in Alzheimer's disease and diabetes. Ann N Y Acad Sci. 1996 Jan 17; 777:89-95. PMID: 8624132.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  60. Busciglio J, Yankner BA. Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature. 1995 Dec 21-28; 378(6559):776-9. PMID: 8524410.
    Citations: 162     Fields:    Translation:HumansCells
  61. Martin BL, Schrader-Fischer G, Busciglio J, Duke M, Paganetti P, Yankner BA. Intracellular accumulation of beta-amyloid in cells expressing the Swedish mutant amyloid precursor protein. J Biol Chem. 1995 Nov 10; 270(45):26727-30. PMID: 7592902.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  62. Busciglio J, Lorenzo A, Yeh J, Yankner BA. beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding. Neuron. 1995 Apr; 14(4):879-88. PMID: 7718249.
    Citations: 179     Fields:    Translation:HumansAnimalsCells
  63. Lorenzo A, Yankner BA. Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red. Proc Natl Acad Sci U S A. 1994 Dec 06; 91(25):12243-7. PMID: 7991613; PMCID: PMC45413.
    Citations: 250     Fields:    Translation:AnimalsCells
  64. Gabuzda D, Busciglio J, Chen LB, Matsudaira P, Yankner BA. Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative. J Biol Chem. 1994 May 06; 269(18):13623-8. PMID: 8175797.
    Citations: 104     Fields:    Translation:HumansCells
  65. Lorenzo A, Razzaboni B, Weir GC, Yankner BA. Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus. Nature. 1994 Apr 21; 368(6473):756-60. PMID: 8152488.
    Citations: 234     Fields:    Translation:HumansAnimalsCells
  66. Gabuzda D, Busciglio J, Yankner BA. Inhibition of beta-amyloid production by activation of protein kinase C. J Neurochem. 1993 Dec; 61(6):2326-9. PMID: 8245986.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  67. Busciglio J, Yeh J, Yankner BA. beta-Amyloid neurotoxicity in human cortical culture is not mediated by excitotoxins. J Neurochem. 1993 Oct; 61(4):1565-8. PMID: 8377009.
    Citations: 19     Fields:    Translation:HumansCells
  68. Busciglio J, Gabuzda DH, Matsudaira P, Yankner BA. Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells. Proc Natl Acad Sci U S A. 1993 Mar 01; 90(5):2092-6. PMID: 8446635; PMCID: PMC46027.
    Citations: 121     Fields:    Translation:AnimalsCells
  69. Kowall NW, McKee AC, Yankner BA, Beal MF. In vivo neurotoxicity of beta-amyloid [beta(1-40)] and the beta(25-35) fragment. Neurobiol Aging. 1992 Sep-Oct; 13(5):537-42. PMID: 1461341.
    Citations: 43     Fields:    Translation:AnimalsCells
  70. Yankner BA. Commentary and perspective on studies of beta amyloid neurotoxicity. Neurobiol Aging. 1992 Sep-Oct; 13(5):615-6. PMID: 1461352.
    Citations: 9     Fields:    Translation:HumansAnimals
  71. Busciglio J, Lorenzo A, Yankner BA. Methodological variables in the assessment of beta amyloid neurotoxicity. Neurobiol Aging. 1992 Sep-Oct; 13(5):609-12. PMID: 1461350.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  72. Chen M, Tempst P, Yankner BA. Secretogranin I/chromogranin B is a heparin-binding adhesive protein. J Neurochem. 1992 May; 58(5):1691-8. PMID: 1560226.
    Citations: 4     Fields:    Translation:AnimalsCells
  73. Yankner BA, Mesulam MM. Seminars in medicine of the Beth Israel Hospital, Boston. beta-Amyloid and the pathogenesis of Alzheimer's disease. N Engl J Med. 1991 Dec 26; 325(26):1849-57. PMID: 1961223.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  74. Kowall NW, Beal MF, Busciglio J, Duffy LK, Yankner BA. An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P. Proc Natl Acad Sci U S A. 1991 Aug 15; 88(16):7247-51. PMID: 1714596; PMCID: PMC52271.
    Citations: 91     Fields:    Translation:AnimalsCells
  75. Chen M, Yankner BA. An antibody to beta amyloid and the amyloid precursor protein inhibits cell-substratum adhesion in many mammalian cell types. Neurosci Lett. 1991 Apr 29; 125(2):223-6. PMID: 1715534.
    Citations: 20     Fields:    Translation:AnimalsCells
  76. Yankner BA, Caceres A, Duffy LK. Nerve growth factor potentiates the neurotoxicity of beta amyloid. Proc Natl Acad Sci U S A. 1990 Nov; 87(22):9020-3. PMID: 2174172; PMCID: PMC55092.
    Citations: 31     Fields:    Translation:AnimalsCells
  77. Yankner BA, Duffy LK, Kirschner DA. Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. Science. 1990 Oct 12; 250(4978):279-82. PMID: 2218531.
    Citations: 412     Fields:    Translation:AnimalsCells
  78. Yankner BA, Benowitz LI, Villa-Komaroff L, Neve RL. Transfection of PC12 cells with the human GAP-43 gene: effects on neurite outgrowth and regeneration. Brain Res Mol Brain Res. 1990 Jan; 7(1):39-44. PMID: 2153893.
    Citations: 34     Fields:    Translation:HumansCells
  79. Neve RL, Dawes LR, Yankner BA, Benowitz LI, Rodriguez W, Higgins GA. Genetics and biology of the Alzheimer amyloid precursor. Prog Brain Res. 1990; 86:257-67. PMID: 2150887.
    Citations: 15     Fields:    Translation:HumansCells
  80. Yankner BA. Amyloid and Alzheimer's disease--cause or effect? Neurobiol Aging. 1989 Sep-Oct; 10(5):470-1; discussion 477-8. PMID: 2682324.
    Citations: 8     Fields:    Translation:Humans
  81. Yankner BA. NGF and Alzheimer's disease--considerations and caveats. Neurobiol Aging. 1989 Sep-Oct; 10(5):546-7; discussion 552-3. PMID: 2812225.
    Citations:    Fields:    Translation:Humans
  82. Yankner BA, Dawes LR, Fisher S, Villa-Komaroff L, Oster-Granite ML, Neve RL. Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. Science. 1989 Jul 28; 245(4916):417-20. PMID: 2474201.
    Citations: 205     Fields:    Translation:HumansCells
  83. Yankner BA, Skolnik PR, Shoukimas GM, Gabuzda DH, Sobel RA, Ho DD. Cerebral granulomatous angiitis associated with isolation of human T-lymphotropic virus type III from the central nervous system. Ann Neurol. 1986 Sep; 20(3):362-4. PMID: 3639720.
    Citations: 15     Fields:    Translation:HumansCells
  84. Yankner BA, Shooter EM. The biology and mechanism of action of nerve growth factor. Annu Rev Biochem. 1982; 51:845-68. PMID: 6287924.
    Citations: 47     Fields:    Translation:Cells
  85. Shooter EM, Yankner BA, Landreth GE, Sutter A. Biosynthesis and mechanism of action of nerve growth factor. Recent Prog Horm Res. 1981; 37:417-46. PMID: 6269164.
    Citations: 8     Fields:    Translation:AnimalsCells
  86. Yankner BA, Shooter EM. Nerve growth factor in the nucleus: interaction with receptors on the nuclear membrane. Proc Natl Acad Sci U S A. 1979 Mar; 76(3):1269-73. PMID: 286309; PMCID: PMC383232.
    Citations: 42     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.