Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

James A. DeCaprio, M.D.

Title
Institution
Department
Address
Phone
Fax

Mentoring
completed student projects
SV40 Large T-antigen-mediated Degradation of the RB-related Protein, p130
Summer, 06/03/99 - 08/03/99

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R35CA232128 (DECAPRIO, JAMES A) Aug 1, 2019 - Jul 31, 2026
    NIH/NCI
    Identification of Novel Oncogenic Signaling Pathways using Viral Perturbations
    Role: Principal Investigator
  2. R25CA221738 (DECAPRIO, JAMES A) Sep 19, 2017 - Aug 31, 2022
    NIH/NCI
    Young Empowered Scientists for ContinUed Research Engagement (YES for CURE)
    Role: Principal Investigator
  3. P01CA203655 (DECAPRIO, JAMES A) Aug 1, 2017 - Jul 31, 2022
    NIH/NCI
    Human Cancer Suppressor Functions of Protein Phosphatase 2A
    Role: Principal Investigator
  4. R01CA173023 (DECAPRIO, JAMES A) Jul 1, 2013 - Nov 30, 2023
    NIH/NCI
    Transforming Mechanisms of Merkel Cell Polyoma Virus
    Role: Principal Investigator
  5. P01CA117969 (DEPINHO, RONALD ANTHONY) Dec 1, 2005 - Mar 31, 2021
    NIH/NCI
    Genetics and Biology of Pancreatic Ductal Adenocarcinoma
    Role: Co-Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Li F, Kozono D, Deraska P, Branigan T, Dunn C, Zheng XF, Parmar K, Nguyen H, DeCaprio J, Shapiro GI, Chowdhury D, D'Andrea AD. CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress. Mol Cell. 2020 Nov 05; 80(3):410-422.e6. PMID: 33108758.
    Citations:    
  2. Hanna GJ, Ruiz ES, LeBoeuf NR, Thakuria M, Schmults CD, Decaprio JA, Silk AW. Real-world outcomes treating patients with advanced cutaneous squamous cell carcinoma with immune checkpoint inhibitors (CPI). Br J Cancer. 2020 Nov; 123(10):1535-1542. PMID: 32868898.
    Citations:    Fields:    
  3. Hanna GJ, Kacew AJ, Tanguturi AR, Grote HJ, Vergara V, Brunkhorst B, Rabinowits G, Thakuria M, LeBoeuf NR, Ihling C, DeCaprio JA, Lorch JH. Association of Programmed Death 1 Protein Ligand (PD-L1) Expression With Prognosis in Merkel Cell Carcinoma. Front Med (Lausanne). 2020; 7:198. PMID: 32582722.
    Citations:    
  4. Park DE, Cheng J, McGrath JP, Lim MY, Cushman C, Swanson SK, Tillgren ML, Paulo JA, Gokhale PC, Florens L, Washburn MP, Trojer P, DeCaprio JA. Author Correction: Merkel cell polyomavirus activates LSD1-mediated blockade of non-canonical BAF to regulate transformation and tumorigenesis. Nat Cell Biol. 2020 06; 22(6):752. PMID: 32415271.
    Citations:    Fields:    
  5. Park DE, Cheng J, McGrath JP, Lim MY, Cushman C, Swanson SK, Tillgren ML, Paulo JA, Gokhale PC, Florens L, Washburn MP, Trojer P, DeCaprio JA. Merkel cell polyomavirus activates LSD1-mediated blockade of non-canonical BAF to regulate transformation and tumorigenesis. Nat Cell Biol. 2020 05; 22(5):603-615. PMID: 32284543.
    Citations:    Fields:    
  6. Nomburg J, Bullman S, Chung SS, Togami K, Walker MA, Griffin GK, Morgan EA, LeBoeuf NR, DeCaprio JA, Meyerson M, Lane AA. Comprehensive metagenomic analysis of blastic plasmacytoid dendritic cell neoplasm. Blood Adv. 2020 03 24; 4(6):1006-1011. PMID: 32182365.
    Citations:    Fields:    
  7. Starrett GJ, Thakuria M, Chen T, Marcelus C, Cheng J, Nomburg J, Thorner AR, Slevin MK, Powers W, Burns RT, Perry C, Piris A, Kuo FC, Rabinowits G, Giobbie-Hurder A, MacConaill LE, DeCaprio JA. Clinical and molecular characterization of virus-positive and virus-negative Merkel cell carcinoma. Genome Med. 2020 03 18; 12(1):30. PMID: 32188490.
    Citations: 3     Fields:    
  8. Slevin MK, Wollison BM, Powers W, Burns RT, Patel N, Ducar MD, Starrett GJ, Garcia EP, Manning DK, Cheng J, Hanna GJ, Kaye KM, Van Hummelen P, Nag A, Thorner AR, DeCaprio JA, MacConaill LE. ViroPanel: Hybrid Capture and Massively Parallel Sequencing for Simultaneous Detection and Profiling of Oncogenic Virus Infection and Tumor Genome. J Mol Diagn. 2020 04; 22(4):476-487. PMID: 32068070.
    Citations: 2     Fields:    
  9. Kim JW, Berrios C, Kim M, Schade AE, Adelmant G, Yeerna H, Damato E, Iniguez AB, Florens L, Washburn MP, Stegmaier K, Gray NS, Tamayo P, Gjoerup O, Marto JA, DeCaprio J, Hahn WC. STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells. Elife. 2020 Jan 08; 9. PMID: 31913126.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  10. Schade AE, Fischer M, DeCaprio JA. RB, p130 and p107 differentially repress G1/S and G2/M genes after p53 activation. Nucleic Acids Res. 2019 12 02; 47(21):11197-11208. PMID: 31667499.
    Citations: 2     Fields:    Translation:HumansCells
  11. Greenfield EA, DeCaprio J, Brahmandam M. Preparing Protein Antigens from Sodium Dodecyl Sulfate-Polyacrylamide Gels for Immunization. Cold Spring Harb Protoc. 2019 12 02; 2019(12). PMID: 31792141.
    Citations:    Fields:    Translation:AnimalsPHPublic Health
  12. Knepper TC, Montesion M, Russell JS, Sokol ES, Frampton GM, Miller VA, Albacker LA, McLeod HL, Eroglu Z, Khushalani NI, Sondak VK, Messina JL, Schell MJ, DeCaprio JA, Tsai KY, Brohl AS. The Genomic Landscape of Merkel Cell Carcinoma and Clinicogenomic Biomarkers of Response to Immune Checkpoint Inhibitor Therapy. Clin Cancer Res. 2019 10 01; 25(19):5961-5971. PMID: 31399473.
    Citations: 8     Fields:    Translation:Humans
  13. Schade AE, Oser MG, Nicholson HE, DeCaprio JA. Cyclin D-CDK4 relieves cooperative repression of proliferation and cell cycle gene expression by DREAM and RB. Oncogene. 2019 06; 38(25):4962-4976. PMID: 30833638.
    Citations: 2     Fields:    Translation:HumansCells
  14. Greenfield EA, DeCaprio J, Brahmandam M. Transfected Dendritic Cell Immunizations. Cold Spring Harb Protoc. 2019 03 01; 2019(3). PMID: 30824623.
    Citations:    Fields:    Translation:AnimalsCells
  15. Menon VR, Ananthapadmanabhan V, Swanson S, Saini S, Sesay F, Yakovlev V, Florens L, DeCaprio JA, Washburn MP, Dozmorov M, Litovchick L. DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169. . 2019 03; 18(5):531-551. PMID: 30773093.
    Citations: 2     Translation:HumansAnimalsCells
  16. Yin S, Gambe RG, Sun J, Martinez AZ, Cartun ZJ, Regis FFD, Wan Y, Fan J, Brooks AN, Herman SEM, Ten Hacken E, Taylor-Weiner A, Rassenti LZ, Ghia EM, Kipps TJ, Obeng EA, Cibulskis CL, Neuberg D, Campagna DR, Fleming MD, Ebert BL, Wiestner A, Leshchiner I, DeCaprio JA, Getz G, Reed R, Carrasco RD, Wu CJ, Wang L. A Murine Model of Chronic Lymphocytic Leukemia Based on B Cell-Restricted Expression of Sf3b1 Mutation and Atm Deletion. Cancer Cell. 2019 02 11; 35(2):283-296.e5. PMID: 30712845.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  17. Goldstein RH, DeCaprio JA. Merkel Cell Carcinoma in the HIV-1/AIDS Patient. Cancer Treat Res. 2019; 177:211-229. PMID: 30523626.
    Citations: 2     Fields:    Translation:HumansCells
  18. Park DE, Cheng J, Berrios C, Montero J, Cortés-Cros M, Ferretti S, Arora R, Tillgren ML, Gokhale PC, DeCaprio JA. Dual inhibition of MDM2 and MDM4 in virus-positive Merkel cell carcinoma enhances the p53 response. Proc Natl Acad Sci U S A. 2019 01 15; 116(3):1027-1032. PMID: 30598450.
    Citations: 8     Fields:    Translation:HumansCells
  19. Zhang J, Chen M, Zhu Y, Dai X, Dang F, Ren J, Ren S, Shulga YV, Beca F, Gan W, Wu F, Lin YM, Zhou X, DeCaprio JA, Beck AH, Lu KP, Huang J, Zhao C, Sun Y, Gao X, Pandolfi PP, Wei W. SPOP Promotes Nanog Destruction to Suppress Stem Cell Traits and Prostate Cancer Progression. Dev Cell. 2019 02 11; 48(3):329-344.e5. PMID: 30595538.
    Citations: 13     Fields:    Translation:HumansCells
  20. Tarnita RM, Wilkie AR, DeCaprio JA. Contribution of DNA Replication to the FAM111A-Mediated Simian Virus 40 Host Range Phenotype. J Virol. 2019 01 01; 93(1). PMID: 30333173.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  21. Harms PW, Harms KL, Moore PS, DeCaprio JA, Nghiem P, Wong MKK, Brownell I. The biology and treatment of Merkel cell carcinoma: current understanding and research priorities. Nat Rev Clin Oncol. 2018 12; 15(12):763-776. PMID: 30287935.
    Citations: 21     Fields:    Translation:HumansCells
  22. DeCaprio J, Kohl TO. Metabolic Labeling of Protein Antigens with [32P]Orthophosphate. Cold Spring Harb Protoc. 2018 09 04; 2018(9). PMID: 30181225.
    Citations:    Fields:    Translation:Cells
  23. Rabinowits G, Lezcano C, Catalano PJ, McHugh P, Becker H, Reilly MM, Huang J, Tyagi A, Thakuria M, Bresler SC, Sholl LM, Shapiro GI, Haddad R, DeCaprio JA. Cabozantinib in Patients with Advanced Merkel Cell Carcinoma. Oncologist. 2018 07; 23(7):814-821. PMID: 29445030.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  24. Becker JC, Stang A, Hausen AZ, Fischer N, DeCaprio JA, Tothill RW, Lyngaa R, Hansen UK, Ritter C, Nghiem P, Bichakjian CK, Ugurel S, Schrama D. Epidemiology, biology and therapy of Merkel cell carcinoma: conclusions from the EU project IMMOMEC. Cancer Immunol Immunother. 2018 03; 67(3):341-351. PMID: 29188306.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  25. Becker JC, Stang A, DeCaprio JA, Cerroni L, Lebbé C, Veness M, Nghiem P. Merkel cell carcinoma. Nat Rev Dis Primers. 2017 Oct 26; 3:17077. PMID: 29072302.
    Citations: 38     Fields:    Translation:Humans
  26. DeCaprio JA. Merkel cell polyomavirus and Merkel cell carcinoma. Philos Trans R Soc Lond B Biol Sci. 2017 Oct 19; 372(1732). PMID: 28893943.
    Citations: 12     Fields:    Translation:HumansCells
  27. Cheng J, Park DE, Berrios C, White EA, Arora R, Yoon R, Branigan T, Xiao T, Westerling T, Federation A, Zeid R, Strober B, Swanson SK, Florens L, Bradner JE, Brown M, Howley PM, Padi M, Washburn MP, DeCaprio JA. Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis. PLoS Pathog. 2017 Oct; 13(10):e1006668. PMID: 29028833.
    Citations: 15     Fields:    Translation:HumansCells
  28. Liu Y, Chen S, Wang S, Soares F, Fischer M, Meng F, Du Z, Lin C, Meyer C, DeCaprio JA, Brown M, Liu XS, He HH. Transcriptional landscape of the human cell cycle. Proc Natl Acad Sci U S A. 2017 03 28; 114(13):3473-3478. PMID: 28289232.
    Citations: 16     Fields:    Translation:HumansCells
  29. Starrett GJ, Marcelus C, Cantalupo PG, Katz JP, Cheng J, Akagi K, Thakuria M, Rabinowits G, Wang LC, Symer DE, Pipas JM, Harris RS, DeCaprio JA. Merkel Cell Polyomavirus Exhibits Dominant Control of the Tumor Genome and Transcriptome in Virus-Associated Merkel Cell Carcinoma. mBio. 2017 01 03; 8(1). PMID: 28049147.
    Citations: 31     Fields:    Translation:HumansCells
  30. Berrios C, Padi M, Keibler MA, Park DE, Molla V, Cheng J, Lee SM, Stephanopoulos G, Quackenbush J, DeCaprio JA. Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation. PLoS Pathog. 2016 Nov; 12(11):e1006020. PMID: 27880818.
    Citations: 17     Fields:    Translation:HumansCells
  31. Odajima J, Saini S, Jung P, Ndassa-Colday Y, Ficaro S, Geng Y, Marco E, Michowski W, Wang YE, DeCaprio JA, Litovchick L, Marto J, Sicinski P. Proteomic Landscape of Tissue-Specific Cyclin E Functions in Vivo. PLoS Genet. 2016 Nov; 12(11):e1006429. PMID: 27828963.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  32. Sridharan V, Muralidhar V, Margalit DN, Tishler RB, DeCaprio JA, Thakuria M, Rabinowits G, Schoenfeld JD. Merkel Cell Carcinoma: A Population Analysis on Survival. J Natl Compr Canc Netw. 2016 10; 14(10):1247-1257. PMID: 27697979.
    Citations: 4     Fields:    Translation:Humans
  33. Choudhury R, Bonacci T, Arceci A, Lahiri D, Mills CA, Kernan JL, Branigan TB, DeCaprio JA, Burke DJ, Emanuele MJ. APC/C and SCF(cyclin F) Constitute a Reciprocal Feedback Circuit Controlling S-Phase Entry. Cell Rep. 2016 09 20; 16(12):3359-3372. PMID: 27653696.
    Citations: 18     Fields:    Translation:HumansCells
  34. Fischer M, Grossmann P, Padi M, DeCaprio JA. Integration of TP53, DREAM, MMB-FOXM1 and RB-E2F target gene analyses identifies cell cycle gene regulatory networks. Nucleic Acids Res. 2016 Jul 27; 44(13):6070-86. PMID: 27280975.
    Citations: 45     Fields:    Translation:HumansCells
  35. Zhang J, Xu K, Liu P, Geng Y, Wang B, Gan W, Guo J, Wu F, Chin YR, Berrios C, Lien EC, Toker A, DeCaprio JA, Sicinski P, Wei W. Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt. Mol Cell. 2016 06 16; 62(6):929-942. PMID: 27237051.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  36. Fischer M, DeCaprio JA. Does Arabidopsis thaliana DREAM of cell cycle control? EMBO J. 2015 Aug 04; 34(15):1987-9. PMID: 26089020.
    Citations: 7     Fields:    Translation:Animals
  37. Spurgeon ME, Cheng J, Bronson RT, Lambert PF, DeCaprio JA. Tumorigenic activity of merkel cell polyomavirus T antigens expressed in the stratified epithelium of mice. Cancer Res. 2015 Mar 15; 75(6):1068-79. PMID: 25596282.
    Citations: 26     Fields:    Translation:AnimalsCells
  38. Berrios C, Jung J, Primi B, Wang M, Pedamallu C, Duke F, Marcelus C, Cheng J, Garcea RL, Meyerson M, DeCaprio JA. Malawi polyomavirus is a prevalent human virus that interacts with known tumor suppressors. J Virol. 2015 Jan; 89(1):857-62. PMID: 25320321.
    Citations: 10     Fields:    Translation:HumansCells
  39. Smith JA, Haberstroh FS, White EA, Livingston DM, DeCaprio JA, Howley PM. SMCX and components of the TIP60 complex contribute to E2 regulation of the HPV E6/E7 promoter. Virology. 2014 Nov; 468-470:311-321. PMID: 25222147.
    Citations: 10     Fields:    Translation:HumansCells
  40. DeCaprio JA, Duensing A. The DREAM complex in antitumor activity of imatinib mesylate in gastrointestinal stromal tumors. Curr Opin Oncol. 2014 Jul; 26(4):415-21. PMID: 24840522.
    Citations: 3     Fields:    Translation:Humans
  41. Naetar N, Soundarapandian V, Litovchick L, Goguen KL, Sablina AA, Bowman-Colin C, Sicinski P, Hahn WC, DeCaprio JA, Livingston DM. PP2A-mediated regulation of Ras signaling in G2 is essential for stable quiescence and normal G1 length. Mol Cell. 2014 Jun 19; 54(6):932-45. PMID: 24857551.
    Citations: 19     Fields:    Translation:HumansCells
  42. Forristal C, Henley SA, MacDonald JI, Bush JR, Ort C, Passos DT, Talluri S, Ishak CA, Thwaites MJ, Norley CJ, Litovchick L, DeCaprio JA, DiMattia G, Holdsworth DW, Beier F, Dick FA. Loss of the mammalian DREAM complex deregulates chondrocyte proliferation. Mol Cell Biol. 2014 Jun; 34(12):2221-34. PMID: 24710275.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  43. Orzalli MH, Conwell SE, Berrios C, DeCaprio JA, Knipe DM. Nuclear interferon-inducible protein 16 promotes silencing of herpesviral and transfected DNA. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):E4492-501. PMID: 24198334.
    Citations: 72     Fields:    Translation:HumansCells
  44. DeCaprio JA. Human papillomavirus type 16 E7 perturbs DREAM to promote cellular proliferation and mitotic gene expression. Oncogene. 2014 Jul 31; 33(31):4036-8. PMID: 24166507.
    Citations: 10     Fields:    Translation:HumansCells
  45. Ivanova T, Alves-Rodrigues I, Gómez-Escoda B, Dutta C, DeCaprio JA, Rhind N, Hidalgo E, Ayté J. The DNA damage and the DNA replication checkpoints converge at the MBF transcription factor. Mol Biol Cell. 2013 Nov; 24(21):3350-7. PMID: 24006488.
    Citations: 12     Fields:    Translation:AnimalsCells
  46. Sadasivam S, DeCaprio JA. The DREAM complex: master coordinator of cell cycle-dependent gene expression. Nat Rev Cancer. 2013 08; 13(8):585-95. PMID: 23842645.
    Citations: 148     Fields:    Translation:Humans
  47. Boichuk S, Parry JA, Makielski KR, Litovchick L, Baron JL, Zewe JP, Wozniak A, Mehalek KR, Korzeniewski N, Seneviratne DS, Schöffski P, Debiec-Rychter M, DeCaprio JA, Duensing A. The DREAM complex mediates GIST cell quiescence and is a novel therapeutic target to enhance imatinib-induced apoptosis. Cancer Res. 2013 Aug 15; 73(16):5120-9. PMID: 23786773.
    Citations: 21     Fields:    Translation:HumansCells
  48. Cheng J, Rozenblatt-Rosen O, Paulson KG, Nghiem P, DeCaprio JA. Merkel cell polyomavirus large T antigen has growth-promoting and inhibitory activities. J Virol. 2013 Jun; 87(11):6118-26. PMID: 23514892.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  49. DeCaprio JA, Garcea RL. A cornucopia of human polyomaviruses. Nat Rev Microbiol. 2013 Apr; 11(4):264-76. PMID: 23474680.
    Citations: 123     Fields:    Translation:HumansAnimalsCells
  50. Rodig SJ, Cheng J, Wardzala J, DoRosario A, Scanlon JJ, Laga AC, Martinez-Fernandez A, Barletta JA, Bellizzi AM, Sadasivam S, Holloway DT, Cooper DJ, Kupper TS, Wang LC, DeCaprio JA. Improved detection suggests all Merkel cell carcinomas harbor Merkel polyomavirus. J Clin Invest. 2012 Dec; 122(12):4645-53. PMID: 23114601.
    Citations: 61     Fields:    Translation:HumansCells
  51. Fine DA, Rozenblatt-Rosen O, Padi M, Korkhin A, James RL, Adelmant G, Yoon R, Guo L, Berrios C, Zhang Y, Calderwood MA, Velmurgan S, Cheng J, Marto JA, Hill DE, Cusick ME, Vidal M, Florens L, Washburn MP, Litovchick L, DeCaprio JA. Identification of FAM111A as an SV40 host range restriction and adenovirus helper factor. PLoS Pathog. 2012; 8(10):e1002949. PMID: 23093934.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  52. Rozenblatt-Rosen O, Deo RC, Padi M, Adelmant G, Calderwood MA, Rolland T, Grace M, Dricot A, Askenazi M, Tavares M, Pevzner SJ, Abderazzaq F, Byrdsong D, Carvunis AR, Chen AA, Cheng J, Correll M, Duarte M, Fan C, Feltkamp MC, Ficarro SB, Franchi R, Garg BK, Gulbahce N, Hao T, Holthaus AM, James R, Korkhin A, Litovchick L, Mar JC, Pak TR, Rabello S, Rubio R, Shen Y, Singh S, Spangle JM, Tasan M, Wanamaker S, Webber JT, Roecklein-Canfield J, Johannsen E, Barabási AL, Beroukhim R, Kieff E, Cusick ME, Hill DE, Münger K, Marto JA, Quackenbush J, Roth FP, DeCaprio JA, Vidal M. Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins. Nature. 2012 Jul 26; 487(7408):491-5. PMID: 22810586.
    Citations: 172     Fields:    Translation:HumansCells
  53. Gulbahce N, Yan H, Dricot A, Padi M, Byrdsong D, Franchi R, Lee DS, Rozenblatt-Rosen O, Mar JC, Calderwood MA, Baldwin A, Zhao B, Santhanam B, Braun P, Simonis N, Huh KW, Hellner K, Grace M, Chen A, Rubio R, Marto JA, Christakis NA, Kieff E, Roth FP, Roecklein-Canfield J, Decaprio JA, Cusick ME, Quackenbush J, Hill DE, Münger K, Vidal M, Barabási AL. Viral perturbations of host networks reflect disease etiology. PLoS Comput Biol. 2012; 8(6):e1002531. PMID: 22761553.
    Citations: 51     Fields:    Translation:HumansCells
  54. Duda DM, Olszewski JL, Tron AE, Hammel M, Lambert LJ, Waddell MB, Mittag T, DeCaprio JA, Schulman BA. Structure of a glomulin-RBX1-CUL1 complex: inhibition of a RING E3 ligase through masking of its E2-binding surface. Mol Cell. 2012 Aug 10; 47(3):371-82. PMID: 22748924.
    Citations: 25     Fields:    Translation:HumansCells
  55. Min SH, Lau AW, Lee TH, Inuzuka H, Wei S, Huang P, Shaik S, Lee DY, Finn G, Balastik M, Chen CH, Luo M, Tron AE, Decaprio JA, Zhou XZ, Wei W, Lu KP. Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase. Mol Cell. 2012 Jun 29; 46(6):771-83. PMID: 22608923.
    Citations: 66     Fields:    Translation:HumansCells
  56. Tron AE, Arai T, Duda DM, Kuwabara H, Olszewski JL, Fujiwara Y, Bahamon BN, Signoretti S, Schulman BA, DeCaprio JA. The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7. Mol Cell. 2012 Apr 13; 46(1):67-78. PMID: 22405651.
    Citations: 21     Fields:    Translation:HumansCells
  57. Sadasivam S, Duan S, DeCaprio JA. The MuvB complex sequentially recruits B-Myb and FoxM1 to promote mitotic gene expression. Genes Dev. 2012 Mar 01; 26(5):474-89. PMID: 22391450.
    Citations: 110     Fields:    Translation:HumansCells
  58. Müller GA, Quaas M, Schümann M, Krause E, Padi M, Fischer M, Litovchick L, DeCaprio JA, Engeland K. The CHR promoter element controls cell cycle-dependent gene transcription and binds the DREAM and MMB complexes. Nucleic Acids Res. 2012 Feb; 40(4):1561-78. PMID: 22064854.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  59. Litovchick L, Florens LA, Swanson SK, Washburn MP, DeCaprio JA. DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly. Genes Dev. 2011 Apr 15; 25(8):801-13. PMID: 21498570.
    Citations: 90     Fields:    Translation:HumansAnimalsCells
  60. Tschöp K, Conery AR, Litovchick L, Decaprio JA, Settleman J, Harlow E, Dyson N. A kinase shRNA screen links LATS2 and the pRB tumor suppressor. Genes Dev. 2011 Apr 15; 25(8):814-30. PMID: 21498571.
    Citations: 56     Fields:    Translation:HumansCells
  61. Gao D, Wan L, Inuzuka H, Berg AH, Tseng A, Zhai B, Shaik S, Bennett E, Tron AE, Gasser JA, Lau A, Gygi SP, Harper JW, DeCaprio JA, Toker A, Wei W. Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction. Mol Cell. 2010 Sep 10; 39(5):797-808. PMID: 20832730.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  62. DeCaprio JA. Does detection of Merkel cell polyomavirus in Merkel cell carcinoma provide prognostic information? J Natl Cancer Inst. 2009 Jul 01; 101(13):905-7. PMID: 19535772.
    Citations: 3     Fields:    Translation:Humans
  63. Harsha HC, Kandasamy K, Ranganathan P, Rani S, Ramabadran S, Gollapudi S, Balakrishnan L, Dwivedi SB, Telikicherla D, Selvan LD, Goel R, Mathivanan S, Marimuthu A, Kashyap M, Vizza RF, Mayer RJ, Decaprio JA, Srivastava S, Hanash SM, Hruban RH, Pandey A. A compendium of potential biomarkers of pancreatic cancer. PLoS Med. 2009 Apr 07; 6(4):e1000046. PMID: 19360088.
    Citations: 125     Fields:    Translation:HumansCells
  64. Cheng J, DeCaprio JA, Fluck MM, Schaffhausen BS. Cellular transformation by Simian Virus 40 and Murine Polyoma Virus T antigens. Semin Cancer Biol. 2009 Aug; 19(4):218-28. PMID: 19505649.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  65. DeCaprio JA. How the Rb tumor suppressor structure and function was revealed by the study of Adenovirus and SV40. Virology. 2009 Feb 20; 384(2):274-84. PMID: 19150725.
    Citations: 43     Fields:    Translation:HumansCells
  66. Kundu ST, Gosavi P, Khapare N, Patel R, Hosing AS, Maru GB, Ingle A, Decaprio JA, Dalal SN. Plakophilin3 downregulation leads to a decrease in cell adhesion and promotes metastasis. Int J Cancer. 2008 Nov 15; 123(10):2303-14. PMID: 18729189.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  67. Garneski KM, DeCaprio JA, Nghiem P. Does a new polyomavirus contribute to Merkel cell carcinoma? Genome Biol. 2008; 9(6):228. PMID: 18598371.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  68. Borger DR, Gavrilescu LC, Bucur MC, Ivan M, Decaprio JA. AMP-activated protein kinase is essential for survival in chronic hypoxia. Biochem Biophys Res Commun. 2008 May 30; 370(2):230-4. PMID: 18359290.
    Citations: 9     Fields:    Translation:HumansCells
  69. Tsutsumi T, Kuwabara H, Arai T, Xiao Y, Decaprio JA. Disruption of the Fbxw8 gene results in pre- and postnatal growth retardation in mice. Mol Cell Biol. 2008 Jan; 28(2):743-51. PMID: 17998335.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  70. Sablina AA, Chen W, Arroyo JD, Corral L, Hector M, Bulmer SE, DeCaprio JA, Hahn WC. The tumor suppressor PP2A Abeta regulates the RalA GTPase. Cell. 2007 Jun 01; 129(5):969-82. PMID: 17540176.
    Citations: 91     Fields:    Translation:HumansCells
  71. Litovchick L, Sadasivam S, Florens L, Zhu X, Swanson SK, Velmurugan S, Chen R, Washburn MP, Liu XS, DeCaprio JA. Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. Mol Cell. 2007 May 25; 26(4):539-51. PMID: 17531812.
    Citations: 169     Fields:    Translation:HumansAnimalsCells
  72. Skaar JR, Florens L, Tsutsumi T, Arai T, Tron A, Swanson SK, Washburn MP, DeCaprio JA. PARC and CUL7 form atypical cullin RING ligase complexes. Cancer Res. 2007 Mar 01; 67(5):2006-14. PMID: 17332328.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  73. Ali SH, Chandraker A, DeCaprio JA. Inhibition of Simian virus 40 large T antigen helicase activity by fluoroquinolones. Antivir Ther. 2007; 12(1):1-6. PMID: 17503741.
    Citations: 21     Fields:    Translation:HumansCells
  74. Poulin DL, DeCaprio JA. Is there a role for SV40 in human cancer? J Clin Oncol. 2006 Sep 10; 24(26):4356-65. PMID: 16963733.
    Citations: 33     Fields:    Translation:HumansCellsPHPublic Health
  75. Kasper JS, Arai T, DeCaprio JA. A novel p53-binding domain in CUL7. Biochem Biophys Res Commun. 2006 Sep 15; 348(1):132-8. PMID: 16875676.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  76. Borger DR, DeCaprio JA. Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53. J Virol. 2006 May; 80(9):4292-303. PMID: 16611888.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  77. Poulin DL, DeCaprio JA. The carboxyl-terminal domain of large T antigen rescues SV40 host range activity in trans independent of acetylation. Virology. 2006 May 25; 349(1):212-21. PMID: 16510165.
    Citations: 9     Fields:    Translation:AnimalsCells
  78. Kasper JS, Kuwabara H, Arai T, Ali SH, DeCaprio JA. Simian virus 40 large T antigen's association with the CUL7 SCF complex contributes to cellular transformation. J Virol. 2005 Sep; 79(18):11685-92. PMID: 16140746.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  79. Skaar JR, Arai T, DeCaprio JA. Dimerization of CUL7 and PARC is not required for all CUL7 functions and mouse development. Mol Cell Biol. 2005 Jul; 25(13):5579-89. PMID: 15964813.
    Citations: 12     Fields:    Translation:AnimalsCells
  80. Litovchick L, Chestukhin A, DeCaprio JA. Glycogen synthase kinase 3 phosphorylates RBL2/p130 during quiescence. Mol Cell Biol. 2004 Oct; 24(20):8970-80. PMID: 15456871.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  81. Poulin DL, Kung AL, DeCaprio JA. p53 targets simian virus 40 large T antigen for acetylation by CBP. J Virol. 2004 Aug; 78(15):8245-53. PMID: 15254196.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  82. Buchmann AM, Skaar JR, DeCaprio JA. Activation of a DNA damage checkpoint response in a TAF1-defective cell line. Mol Cell Biol. 2004 Jun; 24(12):5332-9. PMID: 15169897.
    Citations: 11     Fields:    Translation:AnimalsCells
  83. Dalal SN, Yaffe MB, DeCaprio JA. 14-3-3 family members act coordinately to regulate mitotic progression. . 2004 May; 3(5):672-7. PMID: 15107609.
    Citations: 26     Translation:HumansAnimalsCells
  84. Ali SH, Kasper JS, Arai T, DeCaprio JA. Cul7/p185/p193 binding to simian virus 40 large T antigen has a role in cellular transformation. J Virol. 2004 Mar; 78(6):2749-57. PMID: 14990695.
    Citations: 28     Fields:    Translation:AnimalsCells
  85. Qi H, Gervais ML, Li W, DeCaprio JA, Challis JR, Ohh M. Molecular cloning and characterization of the von Hippel-Lindau-like protein. Mol Cancer Res. 2004 Jan; 2(1):43-52. PMID: 14757845.
    Citations: 1     Fields:    Translation:HumansCells
  86. Towbin H, Bair KW, DeCaprio JA, Eck MJ, Kim S, Kinder FR, Morollo A, Mueller DR, Schindler P, Song HK, van Oostrum J, Versace RW, Voshol H, Wood J, Zabludoff S, Phillips PE. Proteomics-based target identification: bengamides as a new class of methionine aminopeptidase inhibitors. J Biol Chem. 2003 Dec 26; 278(52):52964-71. PMID: 14534293.
    Citations: 32     Fields:    Translation:HumansCells
  87. Lin JY, DeCaprio JA. SV40 large T antigen promotes dephosphorylation of p130. J Biol Chem. 2003 Nov 21; 278(47):46482-7. PMID: 12968030.
    Citations: 10     Fields:    Translation:HumansCells
  88. Arai T, Kasper JS, Skaar JR, Ali SH, Takahashi C, DeCaprio JA. Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis. Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17):9855-60. PMID: 12904573.
    Citations: 53     Fields:    Translation:AnimalsCells
  89. Masutomi K, Yu EY, Khurts S, Ben-Porath I, Currier JL, Metz GB, Brooks MW, Kaneko S, Murakami S, DeCaprio JA, Weinberg RA, Stewart SA, Hahn WC. Telomerase maintains telomere structure in normal human cells. Cell. 2003 Jul 25; 114(2):241-53. PMID: 12887925.
    Citations: 167     Fields:    Translation:HumansCells
  90. Sanhes L, Tang R, Delmer A, DeCaprio JA, Ajchenbaum-Cymbalista F. Fludarabine-induced apoptosis of B chronic lymphocytic leukemia cells includes early cleavage of p27kip1 by caspases. Leukemia. 2003 Jun; 17(6):1104-11. PMID: 12764376.
    Citations: 3     Fields:    Translation:HumansCells
  91. Li D, Zhao R, Lilyestrom W, Gai D, Zhang R, DeCaprio JA, Fanning E, Jochimiak A, Szakonyi G, Chen XS. Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen. Nature. 2003 May 29; 423(6939):512-8. PMID: 12774115.
    Citations: 127     Fields:    Translation:Cells
  92. Chestukhin A, Pfeffer C, Milligan S, DeCaprio JA, Pellman D. Processing, localization, and requirement of human separase for normal anaphase progression. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4574-9. PMID: 12672959.
    Citations: 37     Fields:    Translation:HumansCells
  93. Chestukhin A, DeCaprio JA. Western blot screening for monoclonal antibodies against human separase. J Immunol Methods. 2003 Mar 01; 274(1-2):105-13. PMID: 12609537.
    Citations:    Fields:    Translation:HumansAnimalsCellsPHPublic Health
  94. Baksh S, Widlund HR, Frazer-Abel AA, Du J, Fosmire S, Fisher DE, DeCaprio JA, Modiano JF, Burakoff SJ. NFATc2-mediated repression of cyclin-dependent kinase 4 expression. Mol Cell. 2002 Nov; 10(5):1071-81. PMID: 12453415.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  95. Hahn WC, Dessain SK, Brooks MW, King JE, Elenbaas B, Sabatini DM, DeCaprio JA, Weinberg RA. Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Mol Cell Biol. 2002 Apr; 22(7):2111-23. PMID: 11884599.
    Citations: 237     Fields:    Translation:HumansCells
  96. Brunet A, Kanai F, Stehn J, Xu J, Sarbassova D, Frangioni JV, Dalal SN, DeCaprio JA, Greenberg ME, Yaffe MB. 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport. J Cell Biol. 2002 Mar 04; 156(5):817-28. PMID: 11864996.
    Citations: 164     Fields:    Translation:HumansAnimalsCells
  97. Chestukhin A, Litovchick L, Rudich K, DeCaprio JA. Nucleocytoplasmic shuttling of p130/RBL2: novel regulatory mechanism. Mol Cell Biol. 2002 Jan; 22(2):453-68. PMID: 11756542.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  98. Ayté J, Schweitzer C, Zarzov P, Nurse P, DeCaprio JA. Feedback regulation of the MBF transcription factor by cyclin Cig2. Nat Cell Biol. 2001 Dec; 3(12):1043-50. PMID: 11781565.
    Citations: 24     Fields:    Translation:AnimalsCells
  99. Hall C, Nelson DM, Ye X, Baker K, DeCaprio JA, Seeholzer S, Lipinski M, Adams PD. HIRA, the human homologue of yeast Hir1p and Hir2p, is a novel cyclin-cdk2 substrate whose expression blocks S-phase progression. Mol Cell Biol. 2001 Mar; 21(5):1854-65. PMID: 11238922.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  100. Ali SH, DeCaprio JA. Cellular transformation by SV40 large T antigen: interaction with host proteins. Semin Cancer Biol. 2001 Feb; 11(1):15-23. PMID: 11243895.
    Citations: 120     Fields:    Translation:HumansAnimals
  101. Zalvide J, DeCaprio JA, Stubdal H. Binding of SV40 large T antigen to the retinoblastoma susceptibility gene product and related proteins. Methods Mol Biol. 2001; 165:213-8. PMID: 11217388.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  102. Miyake S, Sellers WR, Safran M, Li X, Zhao W, Grossman SR, Gan J, DeCaprio JA, Adams PD, Kaelin WG. Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle. Mol Cell Biol. 2000 Dec; 20(23):8889-902. PMID: 11073989.
    Citations: 41     Fields:    Translation:Cells
  103. Canhoto AJ, Chestukhin A, Litovchick L, DeCaprio JA. Phosphorylation of the retinoblastoma-related protein p130 in growth-arrested cells. Oncogene. 2000 Oct 19; 19(44):5116-22. PMID: 11042701.
    Citations: 16     Fields:    Translation:AnimalsCells
  104. Chao HH, Buchmann AM, DeCaprio JA. Loss of p19(ARF) eliminates the requirement for the pRB-binding motif in simian virus 40 large T antigen-mediated transformation. Mol Cell Biol. 2000 Oct; 20(20):7624-33. PMID: 11003658.
    Citations: 11     Fields:    Translation:AnimalsCells
  105. Vairo G, Soos TJ, Upton TM, Zalvide J, DeCaprio JA, Ewen ME, Koff A, Adams JM. Bcl-2 retards cell cycle entry through p27(Kip1), pRB relative p130, and altered E2F regulation. Mol Cell Biol. 2000 Jul; 20(13):4745-53. PMID: 10848600.
    Citations: 41     Fields:    Translation:AnimalsCells
  106. Baksh S, DeCaprio JA, Burakoff SJ. Calcineurin regulation of the mammalian G0/G1 checkpoint element, cyclin dependent kinase 4. Oncogene. 2000 Jun 01; 19(24):2820-7. PMID: 10851085.
    Citations: 13     Fields:    Translation:HumansCells
  107. Gjoerup O, Chao H, DeCaprio JA, Roberts TM. pRB-dependent, J domain-independent function of simian virus 40 large T antigen in override of p53 growth suppression. J Virol. 2000 Jan; 74(2):864-74. PMID: 10623749.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  108. Lai A, Lee JM, Yang WM, DeCaprio JA, Kaelin WG, Seto E, Branton PE. RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins. Mol Cell Biol. 1999 Oct; 19(10):6632-41. PMID: 10490602.
    Citations: 60     Fields:    Translation:Cells
  109. Bauer PH, Cui C, Liu WR, Stehle T, Harrison SC, DeCaprio JA, Benjamin TL. Discrimination between sialic acid-containing receptors and pseudoreceptors regulates polyomavirus spread in the mouse. J Virol. 1999 Jul; 73(7):5826-32. PMID: 10364334.
    Citations: 47     Fields:    Translation:AnimalsCells
  110. Dalal SN, Schweitzer CM, Gan J, DeCaprio JA. Cytoplasmic localization of human cdc25C during interphase requires an intact 14-3-3 binding site. Mol Cell Biol. 1999 Jun; 19(6):4465-79. PMID: 10330186.
    Citations: 76     Fields:    Translation:HumansCells
  111. Chauhan D, Hideshima T, Treon S, Teoh G, Raje N, Yoshihimito S, Tai YT, Li W, Fan J, DeCaprio J, Anderson KC. Functional interaction between retinoblastoma protein and stress-activated protein kinase in multiple myeloma cells. Cancer Res. 1999 Mar 15; 59(6):1192-5. PMID: 10096546.
    Citations: 4     Fields:    Translation:HumansCells
  112. DeCaprio JA. The role of the J domain of SV40 large T in cellular transformation. Biologicals. 1999 Mar; 27(1):23-8. PMID: 10441399.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  113. Shim WS, DiRenzo J, DeCaprio JA, Santen RJ, Brown M, Jeng MH. Segregation of steroid receptor coactivator-1 from steroid receptors in mammary epithelium. Proc Natl Acad Sci U S A. 1999 Jan 05; 96(1):208-13. PMID: 9874797.
    Citations: 19     Fields:    Translation:AnimalsCells
  114. Marin MC, Jost CA, Irwin MS, DeCaprio JA, Caput D, Kaelin WG. Viral oncoproteins discriminate between p53 and the p53 homolog p73. Mol Cell Biol. 1998 Nov; 18(11):6316-24. PMID: 9774648.
    Citations: 45     Fields:    Translation:HumansCells
  115. Maheswaran S, Englert C, Zheng G, Lee SB, Wong J, Harkin DP, Bean J, Ezzell R, Garvin AJ, McCluskey RT, DeCaprio JA, Haber DA. Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70. Genes Dev. 1998 Apr 15; 12(8):1108-20. PMID: 9553041.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  116. Zalvide J, Stubdal H, DeCaprio JA. The J domain of simian virus 40 large T antigen is required to functionally inactivate RB family proteins. Mol Cell Biol. 1998 Mar; 18(3):1408-15. PMID: 9488456.
    Citations: 59     Fields:    Translation:Cells
  117. Weiss R, Giordano A, Furth P, DeCaprio J, Pipas J, Ozer H, Strickler H, Procopio A, Garcea R, Carbone M. SV40 as an oncogenic virus and possible human pathogen. Dev Biol Stand. 1998; 94:355-60, 369-82. PMID: 9776256.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  118. Sheng Q, Denis D, Ratnofsky M, Roberts TM, DeCaprio JA, Schaffhausen B. The DnaJ domain of polyomavirus large T antigen is required to regulate Rb family tumor suppressor function. J Virol. 1997 Dec; 71(12):9410-6. PMID: 9371601.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  119. Urashima M, DeCaprio JA, Chauhan D, Teoh G, Ogata A, Treon SP, Hoshi Y, Anderson KC. p16INK4A promotes differentiation and inhibits apoptosis of JKB acute lymphoblastic leukemia cells. Blood. 1997 Nov 15; 90(10):4106-15. PMID: 9354681.
    Citations: 5     Fields:    Translation:HumansCells
  120. Urashima M, Teoh G, Ogata A, Chauhan D, Treon SP, Hoshi Y, DeCaprio JA, Anderson KC. Role of CDK4 and p16INK4A in interleukin-6-mediated growth of multiple myeloma. Leukemia. 1997 Nov; 11(11):1957-63. PMID: 9369432.
    Citations: 4     Fields:    Translation:HumansCells
  121. Ayté J, Leis JF, DeCaprio JA. The fission yeast protein p73res2 is an essential component of the mitotic MBF complex and a master regulator of meiosis. Mol Cell Biol. 1997 Nov; 17(11):6246-54. PMID: 9343385.
    Citations: 6     Fields:    Translation:AnimalsCells
  122. Urashima M, Teoh G, Ogata A, Chauhan D, Treon SP, Sugimoto Y, Kaihara C, Matsuzaki M, Hoshi Y, DeCaprio JA, Anderson KC. Characterization of p16(INK4A) expression in multiple myeloma and plasma cell leukemia. Clin Cancer Res. 1997 Nov; 3(11):2173-9. PMID: 9815612.
    Citations: 10     Fields:    Translation:HumansCells
  123. Stubdal H, Zalvide J, Campbell KS, Schweitzer C, Roberts TM, DeCaprio JA. Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen. Mol Cell Biol. 1997 Sep; 17(9):4979-90. PMID: 9271376.
    Citations: 74     Fields:    Translation:HumansAnimalsCells
  124. Teoh G, Urashima M, Ogata A, Chauhan D, DeCaprio JA, Treon SP, Schlossman RL, Anderson KC. MDM2 protein overexpression promotes proliferation and survival of multiple myeloma cells. Blood. 1997 Sep 01; 90(5):1982-92. PMID: 9292533.
    Citations: 26     Fields:    Translation:HumansCells
  125. Lill NL, Grossman SR, Ginsberg D, DeCaprio J, Livingston DM. Binding and modulation of p53 by p300/CBP coactivators. Nature. 1997 Jun 19; 387(6635):823-7. PMID: 9194565.
    Citations: 215     Fields:    Translation:AnimalsCells
  126. Volker JL, Rameh LE, Zhu Q, DeCaprio J, Hansen U. Mitogenic stimulation of resting T cells causes rapid phosphorylation of the transcription factor LSF and increased DNA-binding activity. Genes Dev. 1997 Jun 01; 11(11):1435-46. PMID: 9192871.
    Citations: 28     Fields:    Translation:HumansCells
  127. Campbell KS, Mullane KP, Aksoy IA, Stubdal H, Zalvide J, Pipas JM, Silver PA, Roberts TM, Schaffhausen BS, DeCaprio JA. DnaJ/hsp40 chaperone domain of SV40 large T antigen promotes efficient viral DNA replication. Genes Dev. 1997 May 01; 11(9):1098-110. PMID: 9159391.
    Citations: 86     Fields:    Translation:HumansAnimalsCells
  128. Peeper DS, Upton TM, Ladha MH, Neuman E, Zalvide J, Bernards R, DeCaprio JA, Ewen ME. Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein. Nature. 1997 Mar 13; 386(6621):177-81. PMID: 9062190.
    Citations: 83     Fields:    Translation:HumansAnimalsCells
  129. Gray-Bablin J, Zalvide J, Fox MP, Knickerbocker CJ, DeCaprio JA, Keyomarsi K. Cyclin E, a redundant cyclin in breast cancer. Proc Natl Acad Sci U S A. 1996 Dec 24; 93(26):15215-20. PMID: 8986790.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  130. Urashima M, Hoshi Y, Sugimoto Y, Kaihara C, Matsuzaki M, Chauhan D, Ogata A, Teoh G, DeCaprio JA, Anderson KC. A novel pre-B acute lymphoblastic leukemia cell line with chromosomal translocation between p16(INK4A)/p15(INK4B) tumor suppressor and immunoglobulin heavy chain genes: TGFbeta/IL-7 inhibitory signaling mechanism. Leukemia. 1996 Oct; 10(10):1576-83. PMID: 8847892.
    Citations: 5     Fields:    Translation:HumansCells
  131. Urashima M, Ogata A, Chauhan D, Vidriales MB, Teoh G, Hoshi Y, Schlossman RL, DeCaprio JA, Anderson KC. Interleukin-6 promotes multiple myeloma cell growth via phosphorylation of retinoblastoma protein. Blood. 1996 Sep 15; 88(6):2219-27. PMID: 8822942.
    Citations: 20     Fields:    Translation:HumansCells
  132. Grafi G, Burnett RJ, Helentjaris T, Larkins BA, DeCaprio JA, Sellers WR, Kaelin WG. A maize cDNA encoding a member of the retinoblastoma protein family: involvement in endoreduplication. Proc Natl Acad Sci U S A. 1996 Aug 20; 93(17):8962-7. PMID: 8799136.
    Citations: 68     Fields:    Translation:AnimalsCells
  133. Eckner R, Ludlow JW, Lill NL, Oldread E, Arany Z, Modjtahedi N, DeCaprio JA, Livingston DM, Morgan JA. Association of p300 and CBP with simian virus 40 large T antigen. Mol Cell Biol. 1996 Jul; 16(7):3454-64. PMID: 8668161.
    Citations: 90     Fields:    Translation:AnimalsCells
  134. Stubdal H, Zalvide J, DeCaprio JA. Simian virus 40 large T antigen alters the phosphorylation state of the RB-related proteins p130 and p107. J Virol. 1996 May; 70(5):2781-8. PMID: 8627752.
    Citations: 39     Fields:    Translation:AnimalsCells
  135. Zalvide J, DeCaprio JA. Role of pRb-related proteins in simian virus 40 large-T-antigen-mediated transformation. Mol Cell Biol. 1995 Oct; 15(10):5800-10. PMID: 7565733.
    Citations: 63     Fields:    Translation:AnimalsCells
  136. Kibel A, Iliopoulos O, DeCaprio JA, Kaelin WG. Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C. Science. 1995 Sep 08; 269(5229):1444-6. PMID: 7660130.
    Citations: 176     Fields:    Translation:HumansAnimalsCells
  137. Ayté J, Leis JF, Herrera A, Tang E, Yang H, DeCaprio JA. The Schizosaccharomyces pombe MBF complex requires heterodimerization for entry into S phase. Mol Cell Biol. 1995 May; 15(5):2589-99. PMID: 7739540.
    Citations: 24     Fields:    Translation:AnimalsCells
  138. Krek W, DeCaprio JA. Cell synchronization. Methods Enzymol. 1995; 254:114-24. PMID: 8531680.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  139. Ginsberg D, Vairo G, Chittenden T, Xiao ZX, Xu G, Wydner KL, DeCaprio JA, Lawrence JB, Livingston DM. E2F-4, a new member of the E2F transcription factor family, interacts with p107. Genes Dev. 1994 Nov 15; 8(22):2665-79. PMID: 7958924.
    Citations: 105     Fields:    Translation:HumansCells
  140. Eckner R, Ewen ME, Newsome D, Gerdes M, DeCaprio JA, Lawrence JB, Livingston DM. Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev. 1994 Apr 15; 8(8):869-84. PMID: 7523245.
    Citations: 339     Fields:    Translation:HumansCells
  141. Chittenden T, Livingston DM, DeCaprio JA. Cell cycle analysis of E2F in primary human T cells reveals novel E2F complexes and biochemically distinct forms of free E2F. Mol Cell Biol. 1993 Jul; 13(7):3975-83. PMID: 8321204.
    Citations: 24     Fields:    Translation:HumansCells
  142. Pitkänen K, Kivinen L, DeCaprio JA, Laiho M. Expression of the human retinoblastoma gene product in mouse fibroblasts: effects on cell proliferation and susceptibility to transformation. Exp Cell Res. 1993 Jul; 207(1):99-106. PMID: 8319776.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  143. Ajchenbaum F, Ando K, DeCaprio JA, Griffin JD. Independent regulation of human D-type cyclin gene expression during G1 phase in primary human T lymphocytes. J Biol Chem. 1993 Feb 25; 268(6):4113-9. PMID: 8382693.
    Citations: 59     Fields:    Translation:HumansCells
  144. Kaelin WG, Krek W, Sellers WR, DeCaprio JA, Ajchenbaum F, Fuchs CS, Chittenden T, Li Y, Farnham PJ, Blanar MA, et al. Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell. 1992 Jul 24; 70(2):351-64. PMID: 1638635.
    Citations: 298     Fields:    Translation:Cells
  145. Ishida Y, Furukawa Y, Decaprio JA, Saito M, Griffin JD. Treatment of myeloid leukemic cells with the phosphatase inhibitor okadaic acid induces cell cycle arrest at either G1/S or G2/M depending on dose. J Cell Physiol. 1992 Mar; 150(3):484-92. PMID: 1311329.
    Citations: 17     Fields:    Translation:HumansCells
  146. DeCaprio JA, Furukawa Y, Ajchenbaum F, Griffin JD, Livingston DM. The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression. Proc Natl Acad Sci U S A. 1992 Mar 01; 89(5):1795-8. PMID: 1531876.
    Citations: 58     Fields:    Translation:HumansCells
  147. Shirodkar S, Ewen M, DeCaprio JA, Morgan J, Livingston DM, Chittenden T. The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner. Cell. 1992 Jan 10; 68(1):157-66. PMID: 1531040.
    Citations: 190     Fields:    Translation:HumansCells
  148. DeCaprio JA, Mayer RJ, Gonin R, Arbuck SG. Fluorouracil and high-dose leucovorin in previously untreated patients with advanced adenocarcinoma of the pancreas: results of a phase II trial. J Clin Oncol. 1991 Dec; 9(12):2128-33. PMID: 1960554.
    Citations: 21     Fields:    Translation:HumansCTClinical Trials
  149. Furukawa Y, DeCaprio JA, Belvin M, Griffin JD. Heterogeneous expression of the product of the retinoblastoma susceptibility gene in primary human leukemia cells. Oncogene. 1991 Aug; 6(8):1343-6. PMID: 1886710.
    Citations: 4     Fields:    Translation:Humans
  150. Kaelin WG, Pallas DC, DeCaprio JA, Kaye FJ, Livingston DM. Identification of cellular proteins that can interact specifically with the T/E1A-binding region of the retinoblastoma gene product. Cell. 1991 Feb 08; 64(3):521-32. PMID: 1825028.
    Citations: 191     Fields:    Translation:HumansCells
  151. Laiho M, Rönnstrand L, Heino J, Decaprio JA, Ludlow JW, Livingston DM, Massagué J. Control of junB and extracellular matrix protein expression by transforming growth factor-beta 1 is independent of simian virus 40 T antigen-sensitive growth-sensitive growth-inhibitory events. Mol Cell Biol. 1991 Feb; 11(2):972-8. PMID: 1990295.
    Citations: 18     Fields:    Translation:AnimalsCells
  152. Laiho M, DeCaprio JA, Ludlow JW, Livingston DM, Massagué J. Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylation. Cell. 1990 Jul 13; 62(1):175-85. PMID: 2163767.
    Citations: 153     Fields:    Translation:AnimalsCells
  153. Furukawa Y, DeCaprio JA, Freedman A, Kanakura Y, Nakamura M, Ernst TJ, Livingston DM, Griffin JD. Expression and state of phosphorylation of the retinoblastoma susceptibility gene product in cycling and noncycling human hematopoietic cells. Proc Natl Acad Sci U S A. 1990 Apr; 87(7):2770-4. PMID: 2320588.
    Citations: 37     Fields:    Translation:HumansCells
  154. Ludlow JW, Shon J, Pipas JM, Livingston DM, DeCaprio JA. The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T. Cell. 1990 Feb 09; 60(3):387-96. PMID: 2154332.
    Citations: 107     Fields:    Translation:HumansAnimalsCells
  155. DeCaprio JA, Ludlow JW, Lynch D, Furukawa Y, Griffin J, Piwnica-Worms H, Huang CM, Livingston DM. The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element. Cell. 1989 Sep 22; 58(6):1085-95. PMID: 2673542.
    Citations: 230     Fields:    Translation:HumansAnimalsCells
  156. Ewen ME, Ludlow JW, Marsilio E, DeCaprio JA, Millikan RC, Cheng SH, Paucha E, Livingston DM. An N-terminal transformation-governing sequence of SV40 large T antigen contributes to the binding of both p110Rb and a second cellular protein, p120. Cell. 1989 Jul 28; 58(2):257-67. PMID: 2526683.
    Citations: 97     Fields:    Translation:HumansAnimalsCells
  157. Ludlow JW, DeCaprio JA, Huang CM, Lee WH, Paucha E, Livingston DM. SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family. Cell. 1989 Jan 13; 56(1):57-65. PMID: 2910497.
    Citations: 143     Fields:    Translation:HumansCells
  158. Livingston DM, DeCaprio JA, Ludlow JW. Does the product of the RB-1 locus have a cell cycle regulatory function? Princess Takamatsu Symp. 1989; 20:187-90. PMID: 2535107.
    Citations: 1     Fields:    Translation:HumansCells
  159. DeCaprio JA, Ludlow JW, Figge J, Shew JY, Huang CM, Lee WH, Marsilio E, Paucha E, Livingston DM. SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell. 1988 Jul 15; 54(2):275-83. PMID: 2839300.
    Citations: 492     Fields:    Translation:AnimalsCells
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