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Michael Todd Valerius, Ph.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U24DK110814 (KESSELMAN, CARL) Sep 15, 2016 - May 31, 2021
    USC GUDMAP Coordinating Center
    Role Description: Funded as the Biocurator for GUDMAP.
    Role: Co-Investigator
  2. DK107350-subaward (VALERIUS, MICHAEL T) Apr 1, 2016 - Mar 31, 2018
    NIH/NIDDK - The USC (Re)Building the Kidney Coordinating Center
    Differentiation of Fluorescent Reporter Human iPS Cell Lines for Monitoring Renal Cell Lineages
    Role Description: Our objective is to aid RBK studies of in vitro cell populations by generating kidney cell type specific human pluripotent stem cell (hPSC) reporter lines using CRISPR/Cas9.
    Role: Principal Investigator
  3. F32DK060319 (VALERIUS, MICHAEL T) Sep 30, 2001 - Sep 29, 2004
    Molecular Regulation of Nephron Formation
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Li L, Galichon P, Xiao X, Figueroa-Ramirez AC, Tamayo D, Lee JJ, Kalocsay M, Gonzalez-Sanchez D, Chancay MS, McCracken KW, Lee NN, Ichimura T, Mori Y, Valerius MT, Wilflingseder J, Lemos DR, Edelman ER, Bonventre JV. Orphan nuclear receptor COUP-TFII enhances myofibroblast glycolysis leading to kidney fibrosis. EMBO Rep. 2021 06 04; 22(6):e51169. PMID: 34031962; PMCID: PMC8183413.
    Citations: 3     Fields:    Translation:AnimalsCells
  2. Wilflingseder J, Willi M, Lee HK, Olauson H, Jankowski J, Ichimura T, Erben R, Valerius MT, Hennighausen L, Bonventre JV. Enhancer and super-enhancer dynamics in repair after ischemic acute kidney injury. Nat Commun. 2020 07 07; 11(1):3383. PMID: 32636391; PMCID: PMC7341735.
    Citations: 10     Fields:    Translation:AnimalsCells
  3. Homan KA, Gupta N, Kroll KT, Kolesky DB, Skylar-Scott M, Miyoshi T, Mau D, Valerius MT, Ferrante T, Bonventre JV, Lewis JA, Morizane R. Flow-enhanced vascularization and maturation of kidney organoids in vitro. Nat Methods. 2019 03; 16(3):255-262. PMID: 30742039; PMCID: PMC6488032.
    Citations: 173     Fields:    Translation:HumansCells
  4. Gupta N, Susa K, Yoda Y, Bonventre JV, Valerius MT, Morizane R. CRISPR/Cas9-based Targeted Genome Editing for the Development of Monogenic Diseases Models with Human Pluripotent Stem Cells. Curr Protoc Stem Cell Biol. 2018 05; 45(1):e50. PMID: 30040245.
    Citations: 5     Fields:    Translation:HumansCells
  5. Ramalingam H, Fessler AR, Das A, Valerius MT, Basta J, Robbins L, Brown AC, Oxburgh L, McMahon AP, Rauchman M, Carroll TJ. Disparate levels of beta-catenin activity determine nephron progenitor cell fate. Dev Biol. 2018 08 01; 440(1):13-21. PMID: 29705331.
    Citations: 18     Fields:    Translation:AnimalsCells
  6. Naiman N, Fujioka K, Fujino M, Valerius MT, Potter SS, McMahon AP, Kobayashi A. Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development. Dev Cell. 2017 05 22; 41(4):349-365.e3. PMID: 28535371; PMCID: PMC5532731.
    Citations: 26     Fields:    Translation:AnimalsCells
  7. Tögel F, Valerius MT, Freedman BS, Iatrino R, Grinstein M, Bonventre JV. Repair after nephron ablation reveals limitations of neonatal neonephrogenesis. JCI Insight. 2017 01 26; 2(2):e88848. PMID: 28138555.
    Citations: 7     Fields:    Translation:AnimalsCells
  8. Oxburgh L, Carroll TJ, Cleaver O, Gossett DR, Hoshizaki DK, Hubbell JA, Humphreys BD, Jain S, Jensen J, Kaplan DL, Kesselman C, Ketchum CJ, Little MH, McMahon AP, Shankland SJ, Spence JR, Valerius MT, Wertheim JA, Wessely O, Zheng Y, Drummond IA. (Re)Building a Kidney. J Am Soc Nephrol. 2017 May; 28(5):1370-1378. PMID: 28096308.
    Citations: 25     Fields:    Translation:HumansCells
  9. Valerius MT. Human Kidney Organoids: Nephron Models of Development and Disease. Transplantation. 2016 06; 100(6):1171-2. PMID: 27203586.
    Citations:    Fields:    Translation:Humans
  10. Masuzaki R, Zhao S, Valerius MT, Tsugawa D, Oya Y, Ray KC, Karp SJ. SOCS2 Balances Metabolic and Restorative Requirements during Liver Regeneration. J Biol Chem. 2016 Feb 12; 291(7):3346-58. PMID: 26703468.
    Citations: 10     Fields:    Translation:AnimalsCells
  11. Morizane R, Lam AQ, Freedman BS, Kishi S, Valerius MT, Bonventre JV. Nephron organoids derived from human pluripotent stem cells model kidney development and injury. Nat Biotechnol. 2015 Nov; 33(11):1193-200. PMID: 26458176; PMCID: PMC4747858.
    Citations: 289     Fields:    Translation:HumansCells
  12. Freedman BS, Brooks CR, Lam AQ, Fu H, Morizane R, Agrawal V, Saad AF, Li MK, Hughes MR, Werff RV, Peters DT, Lu J, Baccei A, Siedlecki AM, Valerius MT, Musunuru K, McNagny KM, Steinman TI, Zhou J, Lerou PH, Bonventre JV. Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids. Nat Commun. 2015 Oct 23; 6:8715. PMID: 26493500.
    Citations: 254     Fields:    Translation:HumansCells
  13. Baek JH, Zeng R, Weinmann-Menke J, Valerius MT, Wada Y, Ajay AK, Colonna M, Kelley VR. IL-34 mediates acute kidney injury and worsens subsequent chronic kidney disease. J Clin Invest. 2015 Aug 03; 125(8):3198-214. PMID: 26121749; PMCID: PMC4563757.
    Citations: 54     Fields:    Translation:AnimalsCells
  14. Lindström NO, Chang CH, Valerius MT, Hohenstein P, Davies JA. Node retraction during patterning of the urinary collecting duct system. J Anat. 2015 Jan; 226(1):13-21. PMID: 25292187; PMCID: PMC4299504.
    Citations: 7     Fields:    Translation:AnimalsCells
  15. Almdal TP, Handlos LN, Valerius M, Juul E, Nielsen KE, Vistisen D, Nielsen LB, Sheikh A, Belhadj M, Nadir D, Zinai S, Raposo J, Lund-Andersen H, Witte DR. Glycaemic threshold for diabetes-specific retinopathy among individuals from Saudi Arabia, Algeria and Portugal. Diabetes Res Clin Pract. 2014 Mar; 103(3):e44-6. PMID: 24485346.
    Citations: 4     Fields:    Translation:Humans
  16. Lam AQ, Freedman BS, Morizane R, Lerou PH, Valerius MT, Bonventre JV. Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers. J Am Soc Nephrol. 2014 Jun; 25(6):1211-25. PMID: 24357672.
    Citations: 124     Fields:    Translation:HumansAnimalsCells
  17. Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu HS, Brennan J, Armstrong J, Little MH, McMahon AP, Southard-Smith EM. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Front Neurosci. 2012; 6:130. PMID: 22988430.
    Citations: 14     
  18. Park JS, Ma W, O'Brien LL, Chung E, Guo JJ, Cheng JG, Valerius MT, McMahon JA, Wong WH, McMahon AP. Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networks. Dev Cell. 2012 Sep 11; 23(3):637-51. PMID: 22902740.
    Citations: 131     Fields:    Translation:AnimalsCells
  19. Yu J, Valerius MT, Duah M, Staser K, Hansard JK, Guo JJ, McMahon J, Vaughan J, Faria D, Georgas K, Rumballe B, Ren Q, Krautzberger AM, Junker JP, Thiagarajan RD, Machanick P, Gray PA, van Oudenaarden A, Rowitch DH, Stiles CD, Ma Q, Grimmond SM, Bailey TL, Little MH, McMahon AP. Identification of molecular compartments and genetic circuitry in the developing mammalian kidney. Development. 2012 May; 139(10):1863-73. PMID: 22510988.
    Citations: 35     Fields:    Translation:Animals
  20. Balasubramanian S, Jansen M, Valerius MT, Humphreys BD, Strom TB. Orphan nuclear receptor Nur77 promotes acute kidney injury and renal epithelial apoptosis. J Am Soc Nephrol. 2012 Apr; 23(4):674-86. PMID: 22343121.
    Citations: 21     Fields:    Translation:AnimalsCells
  21. Valerius MT. Bowman's ß-catenin. J Am Soc Nephrol. 2012 Jan; 23(1):3-4. PMID: 22158436.
    Citations: 1     Fields:    Translation:AnimalsCells
  22. Boyle SC, Kim M, Valerius MT, McMahon AP, Kopan R. Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cells. Development. 2011 Oct; 138(19):4245-54. PMID: 21852398.
    Citations: 44     Fields:    Translation:AnimalsCells
  23. Balasubramanian S, Kota SK, Valerius MT. The rejection barrier to induced pluripotent stem cells. J Am Soc Nephrol. 2011 Sep; 22(9):1583-6. PMID: 21836145.
    Citations:    Fields:    Translation:HumansAnimalsCells
  24. Nagalakshmi VK, Ren Q, Pugh MM, Valerius MT, McMahon AP, Yu J. Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney. Kidney Int. 2011 Feb; 79(3):317-30. PMID: 20944551.
    Citations: 87     Fields:    Translation:AnimalsCells
  25. Humphreys BD, Lin SL, Kobayashi A, Hudson TE, Nowlin BT, Bonventre JV, Valerius MT, McMahon AP, Duffield JS. Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol. 2010 Jan; 176(1):85-97. PMID: 20008127; PMCID: PMC2797872.
    Citations: 656     Fields:    Translation:AnimalsCells
  26. Georgas K, Rumballe B, Valerius MT, Chiu HS, Thiagarajan RD, Lesieur E, Aronow BJ, Brunskill EW, Combes AN, Tang D, Taylor D, Grimmond SM, Potter SS, McMahon AP, Little MH. Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Dev Biol. 2009 Aug 15; 332(2):273-86. PMID: 19501082.
    Citations: 123     Fields:    Translation:HumansAnimals
  27. Brunskill EW, Aronow BJ, Georgas K, Rumballe B, Valerius MT, Aronow J, Kaimal V, Jegga AG, Yu J, Grimmond S, McMahon AP, Patterson LT, Little MH, Potter SS. Atlas of gene expression in the developing kidney at microanatomic resolution. Dev Cell. 2008 Nov; 15(5):781-91. PMID: 19000842.
    Citations: 125     Fields:    Translation:Animals
  28. Kobayashi A, Valerius MT, Mugford JW, Carroll TJ, Self M, Oliver G, McMahon AP. Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell. 2008 Aug 07; 3(2):169-81. PMID: 18682239.
    Citations: 466     Fields:    Translation:AnimalsCells
  29. Humphreys BD, Valerius MT, Kobayashi A, Mugford JW, Soeung S, Duffield JS, McMahon AP, Bonventre JV. Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell. 2008 Mar 06; 2(3):284-91. PMID: 18371453.
    Citations: 368     Fields:    Translation:AnimalsCells
  30. Valerius MT, McMahon AP. Transcriptional profiling of Wnt4 mutant mouse kidneys identifies genes expressed during nephron formation. Gene Expr Patterns. 2008 May; 8(5):297-306. PMID: 18346943.
    Citations: 15     Fields:    Translation:AnimalsCells
  31. Park JS, Valerius MT, McMahon AP. Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development. Development. 2007 Jul; 134(13):2533-9. PMID: 17537789.
    Citations: 184     Fields:    Translation:AnimalsCells
  32. Little MH, Brennan J, Georgas K, Davies JA, Davidson DR, Baldock RA, Beverdam A, Bertram JF, Capel B, Chiu HS, Clements D, Cullen-McEwen L, Fleming J, Gilbert T, Herzlinger D, Houghton D, Kaufman MH, Kleymenova E, Koopman PA, Lewis AG, McMahon AP, Mendelsohn CL, Mitchell EK, Rumballe BA, Sweeney DE, Valerius MT, Yamada G, Yang Y, Yu J. A high-resolution anatomical ontology of the developing murine genitourinary tract. Gene Expr Patterns. 2007 Jun; 7(6):680-99. PMID: 17452023; PMCID: PMC2117077.
    Citations: 74     Fields:    Translation:Animals
  33. Cheng HT, Kim M, Valerius MT, Surendran K, Schuster-Gossler K, Gossler A, McMahon AP, Kopan R. Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development. 2007 Feb; 134(4):801-11. PMID: 17229764.
    Citations: 170     Fields:    Translation:Animals
  34. Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q. Mouse brain organization revealed through direct genome-scale TF expression analysis. Science. 2004 Dec 24; 306(5705):2255-7. PMID: 15618518.
    Citations: 222     Fields:    Translation:Animals
  35. Yu J, McMahon AP, Valerius MT. Recent genetic studies of mouse kidney development. Curr Opin Genet Dev. 2004 Oct; 14(5):550-7. PMID: 15380247.
    Citations: 43     Fields:    Translation:Animals
  36. Valerius MT, Patterson LT, Feng Y, Potter SS. Hoxa 11 is upstream of Integrin alpha8 expression in the developing kidney. Proc Natl Acad Sci U S A. 2002 Jun 11; 99(12):8090-5. PMID: 12060755; PMCID: PMC123025.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  37. Valerius MT, Patterson LT, Witte DP, Potter SS. Microarray analysis of novel cell lines representing two stages of metanephric mesenchyme differentiation. Mech Dev. 2002 Mar; 112(1-2):219-32. PMID: 11850199.
    Citations: 30     Fields:    Translation:AnimalsCells
  38. Valerius MT, Patterson LT, Witte DP, Potter SS. Microarray analysis of novel cell lines representing two stages of metanephric mesenchyme differentiation. Mech Dev. 2002 Jan; 110(1-2):151-64. PMID: 11744376.
    Citations: 12     Fields:    Translation:AnimalsCells
  39. Potter SS, Valerius MT, Brunskill EW. Using progenitor cells and gene chips to define genetic pathways. Methods Mol Biol. 2002; 185:269-84. PMID: 11768995.
    Citations:    Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.