Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Kazuhide Hayakawa, Ph.D.

Co-Author

This page shows the publications co-authored by Kazuhide Hayakawa and Eng Lo.
Connection Strength

12.509
  1. Hayakawa K, Chan SJ, Mandeville ET, Park JH, Bruzzese M, Montaner J, Arai K, Rosell A, Lo EH. Protective Effects of Endothelial Progenitor Cell-Derived Extracellular Mitochondria in Brain Endothelium. Stem Cells. 2018 09; 36(9):1404-1410.
    View in: PubMed
    Score: 0.849
  2. Hayakawa K, Bruzzese M, Chou SH, Ning M, Ji X, Lo EH. Extracellular Mitochondria for Therapy and Diagnosis in Acute Central Nervous System Injury. JAMA Neurol. 2018 01 01; 75(1):119-122.
    View in: PubMed
    Score: 0.818
  3. Hayakawa K, Esposito E, Wang X, Terasaki Y, Liu Y, Xing C, Ji X, Lo EH. Corrigendum: Transfer of mitochondria from astrocytes to neurons after stroke. Nature. 2016 11 03; 539(7627):123.
    View in: PubMed
    Score: 0.748
  4. Hayakawa K, Esposito E, Wang X, Terasaki Y, Liu Y, Xing C, Ji X, Lo EH. Transfer of mitochondria from astrocytes to neurons after stroke. Nature. 2016 07 28; 535(7613):551-5.
    View in: PubMed
    Score: 0.741
  5. Hayakawa K, Wang X, Lo EH. CD200 increases alternatively activated macrophages through cAMP-response element binding protein - C/EBP-beta signaling. J Neurochem. 2016 Mar; 136(5):900-6.
    View in: PubMed
    Score: 0.713
  6. Hayakawa K, Pham LD, Seo JH, Miyamoto N, Maki T, Terasaki Y, Sakadžic S, Boas D, van Leyen K, Waeber C, Kim KW, Arai K, Lo EH. CD200 restrains macrophage attack on oligodendrocyte precursors via toll-like receptor 4 downregulation. J Cereb Blood Flow Metab. 2016 Apr; 36(4):781-93.
    View in: PubMed
    Score: 0.700
  7. Hayakawa K, Lo EH. Brain-peripheral cell crosstalk in white matter damage and repair. Biochim Biophys Acta. 2016 05; 1862(5):901-8.
    View in: PubMed
    Score: 0.693
  8. Hayakawa K, Pham LD, Arai K, Lo EH. Reactive astrocytes promote adhesive interactions between brain endothelium and endothelial progenitor cells via HMGB1 and beta-2 integrin signaling. Stem Cell Res. 2014 Mar; 12(2):531-8.
    View in: PubMed
    Score: 0.620
  9. Hayakawa K, Pham LD, Arai K, Lo EH. High-mobility group box 1: an amplifier of stem and progenitor cell activity after stroke. Acta Neurochir Suppl. 2013; 118:31-8.
    View in: PubMed
    Score: 0.579
  10. Hayakawa K, Pham LD, Katusic ZS, Arai K, Lo EH. Astrocytic high-mobility group box 1 promotes endothelial progenitor cell-mediated neurovascular remodeling during stroke recovery. Proc Natl Acad Sci U S A. 2012 May 08; 109(19):7505-10.
    View in: PubMed
    Score: 0.551
  11. Hayakawa K, Qiu J, Lo EH. Biphasic actions of HMGB1 signaling in inflammation and recovery after stroke. Ann N Y Acad Sci. 2010 Oct; 1207:50-7.
    View in: PubMed
    Score: 0.495
  12. Hayakawa K, Arai K, Lo EH. Role of ERK map kinase and CRM1 in IL-1beta-stimulated release of HMGB1 from cortical astrocytes. Glia. 2010 Jun; 58(8):1007-15.
    View in: PubMed
    Score: 0.484
  13. Nakamura Y, Lo EH, Hayakawa K. Placental Mitochondria Therapy for Cerebral Ischemia-Reperfusion Injury in Mice. Stroke. 2020 10; 51(10):3142-3146.
    View in: PubMed
    Score: 0.246
  14. Esposito E, Li W, Mandeville ET, Park JH, Sencan I, Guo S, Shi J, Lan J, Lee J, Hayakawa K, Sakadžic S, Ji X, Lo EH. Author Correction: Potential circadian effects on translational failure for neuroprotection. Nature. 2020 Jul; 583(7814):E14.
    View in: PubMed
    Score: 0.243
  15. Esposito E, Li W, T Mandeville E, Park JH, Sencan I, Guo S, Shi J, Lan J, Lee J, Hayakawa K, Sakadžic S, Ji X, Lo EH. Potential circadian effects on translational failure for neuroprotection. Nature. 2020 06; 582(7812):395-398.
    View in: PubMed
    Score: 0.242
  16. Esposito E, Ahn BJ, Shi J, Nakamura Y, Park JH, Mandeville ET, Yu Z, Chan SJ, Desai R, Hayakawa A, Ji X, Lo EH, Hayakawa K. Brain-to-cervical lymph node signaling after stroke. Nat Commun. 2019 11 22; 10(1):5306.
    View in: PubMed
    Score: 0.233
  17. Chan SJ, Niu W, Hayakawa K, Hamanaka G, Wang X, Cheah PS, Guo S, Yu Z, Arai K, Selim MH, Kurisawa M, Spector M, Lo EH. Promoting Neuro-Supportive Properties of Astrocytes with Epidermal Growth Factor Hydrogels. Stem Cells Transl Med. 2019 12; 8(12):1242-1248.
    View in: PubMed
    Score: 0.230
  18. Huang L, Nakamura Y, Lo EH, Hayakawa K. Astrocyte Signaling in the Neurovascular Unit After Central Nervous System Injury. Int J Mol Sci. 2019 Jan 11; 20(2).
    View in: PubMed
    Score: 0.220
  19. Esposito E, Hayakawa K, Ahn BJ, Chan SJ, Xing C, Liang AC, Kim KW, Arai K, Lo EH. Effects of ischemic post-conditioning on neuronal VEGF regulation and microglial polarization in a rat model of focal cerebral ischemia. J Neurochem. 2018 07; 146(2):160-172.
    View in: PubMed
    Score: 0.210
  20. Chou SH, Lan J, Esposito E, Ning M, Balaj L, Ji X, Lo EH, Hayakawa K. Extracellular Mitochondria in Cerebrospinal Fluid and Neurological Recovery After Subarachnoid Hemorrhage. Stroke. 2017 08; 48(8):2231-2237.
    View in: PubMed
    Score: 0.197
  21. Xing C, Hayakawa K, Lo EH. Mechanisms, Imaging, and Therapy in Stroke Recovery. Transl Stroke Res. 2017 02; 8(1):1-2.
    View in: PubMed
    Score: 0.188
  22. Choi YK, Maki T, Mandeville ET, Koh SH, Hayakawa K, Arai K, Kim YM, Whalen MJ, Xing C, Wang X, Kim KW, Lo EH. Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury. Nat Med. 2016 11; 22(11):1335-1341.
    View in: PubMed
    Score: 0.187
  23. Guo S, Lok J, Zhao S, Leung W, Som AT, Hayakawa K, Wang Q, Xing C, Wang X, Ji X, Zhou Y, Lo EH. Effects of Controlled Cortical Impact on the Mouse Brain Vasculome. J Neurotrauma. 2016 07 15; 33(14):1303-16.
    View in: PubMed
    Score: 0.179
  24. Esposito E, Hayakawa K, Maki T, Arai K, Lo EH. Effects of Postconditioning on Neurogenesis and Angiogenesis During the Recovery Phase After Focal Cerebral Ischemia. Stroke. 2015 Sep; 46(9):2691-4.
    View in: PubMed
    Score: 0.173
  25. Guo S, Lok J, Liu Y, Hayakawa K, Leung W, Xing C, Ji X, Lo EH. Assays to examine endothelial cell migration, tube formation, and gene expression profiles. Methods Mol Biol. 2014; 1135:393-402.
    View in: PubMed
    Score: 0.155
  26. Esposito E, Mandeville ET, Hayakawa K, Singhal AB, Lo EH. Effects of normobaric oxygen on the progression of focal cerebral ischemia in rats. Exp Neurol. 2013 Nov; 249:33-8.
    View in: PubMed
    Score: 0.151
  27. Hayakawa K, Miyamoto N, Seo JH, Pham LD, Kim KW, Lo EH, Arai K. High-mobility group box 1 from reactive astrocytes enhances the accumulation of endothelial progenitor cells in damaged white matter. J Neurochem. 2013 Apr; 125(2):273-80.
    View in: PubMed
    Score: 0.145
  28. Xing C, Hayakawa K, Lok J, Arai K, Lo EH. Injury and repair in the neurovascular unit. Neurol Res. 2012 May; 34(4):325-30.
    View in: PubMed
    Score: 0.138
  29. Hayakawa K, Seo JH, Pham LD, Miyamoto N, Som AT, Guo S, Kim KW, Lo EH, Arai K. Cerebral endothelial derived vascular endothelial growth factor promotes the migration but not the proliferation of oligodendrocyte precursor cells in vitro. Neurosci Lett. 2012 Mar 28; 513(1):42-6.
    View in: PubMed
    Score: 0.136
  30. Hayakawa K, Pham LD, Som AT, Lee BJ, Guo S, Lo EH, Arai K. Vascular endothelial growth factor regulates the migration of oligodendrocyte precursor cells. J Neurosci. 2011 Jul 20; 31(29):10666-70.
    View in: PubMed
    Score: 0.131
  31. Arai K, Lok J, Guo S, Hayakawa K, Xing C, Lo EH. Cellular mechanisms of neurovascular damage and repair after stroke. J Child Neurol. 2011 Sep; 26(9):1193-8.
    View in: PubMed
    Score: 0.130
  32. Navaratna D, Guo SZ, Hayakawa K, Wang X, Gerhardinger C, Lo EH. Decreased cerebrovascular brain-derived neurotrophic factor-mediated neuroprotection in the diabetic brain. Diabetes. 2011 Jun; 60(6):1789-96.
    View in: PubMed
    Score: 0.129
  33. Hayakawa K, Nakano T, Irie K, Higuchi S, Fujioka M, Orito K, Iwasaki K, Jin G, Lo EH, Mishima K, Fujiwara M. Inhibition of reactive astrocytes with fluorocitrate retards neurovascular remodeling and recovery after focal cerebral ischemia in mice. J Cereb Blood Flow Metab. 2010 Apr; 30(4):871-82.
    View in: PubMed
    Score: 0.117
  34. Chan SJ, Esposito E, Hayakawa K, Mandaville E, Smith RAA, Guo S, Niu W, Wong PT, Cool SM, Lo EH, Nurcombe V. Vascular Endothelial Growth Factor 165-Binding Heparan Sulfate Promotes Functional Recovery From Cerebral Ischemia. Stroke. 2020 09; 51(9):2844-2853.
    View in: PubMed
    Score: 0.061
  35. Egawa N, Suzuki H, Takahashi R, Hayakawa K, Li W, Lo EH, Arai K, Inoue H. From in vitro to in vivo reprogramming for neural transdifferentiation: An approach for CNS tissue remodeling using stem cell technology. J Cereb Blood Flow Metab. 2020 Sep; 40(9):1739-1751.
    View in: PubMed
    Score: 0.060
  36. Takase H, Chou SH, Hamanaka G, Ohtomo R, Islam MR, Lee JW, Hsu L, Mathew J, Reyes-Bricio E, Hayakawa K, Xing C, Ning MM, Wang X, Arai K, Lo EH, Lok J. Soluble vascular endothelial-cadherin in CSF after subarachnoid hemorrhage. Neurology. 2020 03 24; 94(12):e1281-e1293.
    View in: PubMed
    Score: 0.059
  37. Chan SJ, Zhao H, Hayakawa K, Chai C, Tan CT, Huang J, Tao R, Hamanaka G, Arumugam TV, Lo EH, Yu VCK, Wong PH. Modulator of apoptosis-1 is a potential therapeutic target in acute ischemic injury. J Cereb Blood Flow Metab. 2019 12; 39(12):2406-2418.
    View in: PubMed
    Score: 0.053
  38. Maki T, Morancho A, Martinez-San Segundo P, Hayakawa K, Takase H, Liang AC, Gabriel-Salazar M, Medina-Gutiérrez E, Washida K, Montaner J, Lok J, Lo EH, Arai K, Rosell A. Endothelial Progenitor Cell Secretome and Oligovascular Repair in a Mouse Model of Prolonged Cerebral Hypoperfusion. Stroke. 2018 04; 49(4):1003-1010.
    View in: PubMed
    Score: 0.052
  39. Takase H, Washida K, Hayakawa K, Arai K, Wang X, Lo EH, Lok J. Oligodendrogenesis after traumatic brain injury. Behav Brain Res. 2018 03 15; 340:205-211.
    View in: PubMed
    Score: 0.047
  40. Seo JH, Maki T, Maeda M, Miyamoto N, Liang AC, Hayakawa K, Pham LD, Suwa F, Taguchi A, Matsuyama T, Ihara M, Kim KW, Lo EH, Arai K. Oligodendrocyte precursor cells support blood-brain barrier integrity via TGF-ß signaling. PLoS One. 2014; 9(7):e103174.
    View in: PubMed
    Score: 0.040
  41. Terasaki Y, Liu Y, Hayakawa K, Pham LD, Lo EH, Ji X, Arai K. Mechanisms of neurovascular dysfunction in acute ischemic brain. Curr Med Chem. 2014; 21(18):2035-42.
    View in: PubMed
    Score: 0.039
  42. Miyamoto N, Maki T, Pham LD, Hayakawa K, Seo JH, Mandeville ET, Mandeville JB, Kim KW, Lo EH, Arai K. Oxidative stress interferes with white matter renewal after prolonged cerebral hypoperfusion in mice. Stroke. 2013 Dec; 44(12):3516-21.
    View in: PubMed
    Score: 0.038
  43. Li Q, Atochin D, Kashiwagi S, Earle J, Wang A, Mandeville E, Hayakawa K, d'Uscio LV, Lo EH, Katusic Z, Sessa W, Huang PL. Deficient eNOS phosphorylation is a mechanism for diabetic vascular dysfunction contributing to increased stroke size. Stroke. 2013 Nov; 44(11):3183-8.
    View in: PubMed
    Score: 0.038
  44. Won SY, Schlunk F, Dinkel J, Karatas H, Leung W, Hayakawa K, Lauer A, Steinmetz H, Lo EH, Foerch C, Gupta R. Imaging of contrast medium extravasation in anticoagulation-associated intracerebral hemorrhage with dual-energy computed tomography. Stroke. 2013 Oct; 44(10):2883-90.
    View in: PubMed
    Score: 0.038
  45. Miyamoto N, Pham LD, Hayakawa K, Matsuzaki T, Seo JH, Magnain C, Ayata C, Kim KW, Boas D, Lo EH, Arai K. Age-related decline in oligodendrogenesis retards white matter repair in mice. Stroke. 2013 Sep; 44(9):2573-8.
    View in: PubMed
    Score: 0.038
  46. Maki T, Hayakawa K, Pham LD, Xing C, Lo EH, Arai K. Biphasic mechanisms of neurovascular unit injury and protection in CNS diseases. CNS Neurol Disord Drug Targets. 2013 May 01; 12(3):302-15.
    View in: PubMed
    Score: 0.037
  47. Seo JH, Miyamoto N, Hayakawa K, Pham LD, Maki T, Ayata C, Kim KW, Lo EH, Arai K. Oligodendrocyte precursors induce early blood-brain barrier opening after white matter injury. J Clin Invest. 2013 Feb; 123(2):782-6.
    View in: PubMed
    Score: 0.036
  48. Zhao S, Yu Z, Zhao G, Xing C, Hayakawa K, Whalen MJ, Lok JM, Lo EH, Wang X. Neuroglobin-overexpression reduces traumatic brain lesion size in mice. BMC Neurosci. 2012 Jun 15; 13:67.
    View in: PubMed
    Score: 0.035
  49. Pham LD, Hayakawa K, Seo JH, Nguyen MN, Som AT, Lee BJ, Guo S, Kim KW, Lo EH, Arai K. Crosstalk between oligodendrocytes and cerebral endothelium contributes to vascular remodeling after white matter injury. Glia. 2012 May; 60(6):875-81.
    View in: PubMed
    Score: 0.034
  50. Schlunk F, Van Cott EM, Hayakawa K, Pfeilschifter W, Lo EH, Foerch C. Recombinant activated coagulation factor VII and prothrombin complex concentrates are equally effective in reducing hematoma volume in experimental warfarin-associated intracerebral hemorrhage. Stroke. 2012 Jan; 43(1):246-9.
    View in: PubMed
    Score: 0.033
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.