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profileKazuhide Hayakawa, Ph.D.

TitleAssistant Professor of Radiology
InstitutionMassachusetts General Hospital
DepartmentRadiology
AddressMassachusetts General Hospital
Radiology, Rm 2401
149 13th Street
Charlestown MA 02129
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Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01NS099620     (LO, ENG H.)Sep 1, 2016 - May 31, 2021
NIH/NINDS
Inflammatory Mechanisms of Brain - Lymphatic Signaling in Stroke
Role: Principal Investigator

R01NS094756     (HAYAKAWA, KAZUHIDE)Sep 1, 2015 - May 31, 2020
NIH/NINDS
Promotion of neurovascular remodeling through mitochondria transfer after stroke
Role: Principal Investigator

K99NS080991     (HAYAKAWA, KAZUHIDE)Dec 1, 2012 - Nov 30, 2014
NIH/NINDS
CD200 as a monocyte/macrophage switch for brain repair after stroke
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Hayakawa K, Bruzzese M, Chou SH, Ning M, Ji X, Lo EH. Extracellular Mitochondria for Therapy and Diagnosis in Acute Central Nervous System Injury. JAMA Neurol. 2017 Nov 20. PMID: 29159397.
    View in: PubMed
  2. Chou SH, Lan J, Esposito E, Ning M, Balaj L, Ji X, Lo EH, Hayakawa K. Extracellular Mitochondria in Cerebrospinal Fluid and Neurological Recovery After Subarachnoid Hemorrhage. Stroke. 2017 Aug; 48(8):2231-2237. PMID: 28663512.
    View in: PubMed
  3. Takase H, Washida K, Hayakawa K, Arai K, Wang X, Lo EH, Lok J. Oligodendrogenesis after traumatic brain injury. Behav Brain Res. 2016 Nov 06. PMID: 27829126.
    View in: PubMed
  4. Xing C, Hayakawa K, Lo EH. Mechanisms, Imaging, and Therapy in Stroke Recovery. Transl Stroke Res. 2017 Feb; 8(1):1-2. PMID: 27714670.
    View in: PubMed
  5. Choi YK, Maki T, Mandeville ET, Koh SH, Hayakawa K, Arai K, Kim YM, Whalen MJ, Xing C, Wang X, Kim KW, Lo EH. Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury. Nat Med. 2016 Nov; 22(11):1335-1341. PMID: 27668935.
    View in: PubMed
  6. Hayakawa K, Esposito E, Wang X, Terasaki Y, Liu Y, Xing C, Ji X, Lo EH. Transfer of mitochondria from astrocytes to neurons after stroke. Nature. 2016 07 28; 535(7613):551-5. PMID: 27466127; PMCID: PMC4968589 [Available on 01/27/17].
  7. Guo S, Lok J, Zhao S, Leung W, Som AT, Hayakawa K, Wang Q, Xing C, Wang X, Ji X, Zhou Y, Lo EH. Effects of Controlled Cortical Impact on the Mouse Brain Vasculome. J Neurotrauma. 2016 Jul 15; 33(14):1303-16. PMID: 26528928; PMCID: PMC4931728 [Available on 07/15/17].
  8. Hayakawa K, Wang X, Lo EH. CD200 increases alternatively activated macrophages through cAMP-response element binding protein - C/EBP-beta signaling. J Neurochem. 2016 Mar; 136(5):900-6. PMID: 26670206; PMCID: PMC4755817 [Available on 03/01/17].
  9. Hayakawa K, Pham LD, Seo JH, Miyamoto N, Maki T, Terasaki Y, Sakadžic S, Boas D, van Leyen K, Waeber C, Kim KW, Arai K, Lo EH. CD200 restrains macrophage attack on oligodendrocyte precursors via toll-like receptor 4 downregulation. J Cereb Blood Flow Metab. 2016 Apr; 36(4):781-93. PMID: 26661156; PMCID: PMC4821018 [Available on 04/01/17].
  10. Hayakawa K, Lo EH. Brain-peripheral cell crosstalk in white matter damage and repair. Biochim Biophys Acta. 2016 May; 1862(5):901-8. PMID: 26277436; PMCID: PMC4752923 [Available on 05/01/17].
  11. Nakano T, Irie K, Hayakawa K, Sano K, Nakamura Y, Tanaka M, Yamashita Y, Satho T, Fujioka M, Muroi C, Matsuo K, Ishikura H, Futagami K, Mishima K. Delayed treatment with ADAMTS13 ameliorates cerebral ischemic injury without hemorrhagic complication. Brain Res. 2015 Oct 22; 1624:330-5. PMID: 26254727.
    View in: PubMed
  12. Esposito E, Hayakawa K, Maki T, Arai K, Lo EH. Effects of Postconditioning on Neurogenesis and Angiogenesis During the Recovery Phase After Focal Cerebral Ischemia. Stroke. 2015 Sep; 46(9):2691-4. PMID: 26243221; PMCID: PMC4604446.
  13. Seo JH, Maki T, Maeda M, Miyamoto N, Liang AC, Hayakawa K, Pham LD, Suwa F, Taguchi A, Matsuyama T, Ihara M, Kim KW, Lo EH, Arai K. Oligodendrocyte precursor cells support blood-brain barrier integrity via TGF-ß signaling. PLoS One. 2014; 9(7):e103174. PMID: 25078775; PMCID: PMC4117639.
  14. Guo S, Lok J, Liu Y, Hayakawa K, Leung W, Xing C, Ji X, Lo EH. Assays to examine endothelial cell migration, tube formation, and gene expression profiles. Methods Mol Biol. 2014; 1135:393-402. PMID: 24510881; PMCID: PMC4035906.
  15. Terasaki Y, Liu Y, Hayakawa K, Pham LD, Lo EH, Ji X, Arai K. Mechanisms of neurovascular dysfunction in acute ischemic brain. Curr Med Chem. 2014; 21(18):2035-42. PMID: 24372202; PMCID: PMC4066327.
  16. Hayakawa K, Pham LD, Arai K, Lo EH. Reactive astrocytes promote adhesive interactions between brain endothelium and endothelial progenitor cells via HMGB1 and beta-2 integrin signaling. Stem Cell Res. 2014 Mar; 12(2):531-8. PMID: 24480450; PMCID: PMC3966549.
  17. Miyamoto N, Maki T, Pham LD, Hayakawa K, Seo JH, Mandeville ET, Mandeville JB, Kim KW, Lo EH, Arai K. Oxidative stress interferes with white matter renewal after prolonged cerebral hypoperfusion in mice. Stroke. 2013 Dec; 44(12):3516-21. PMID: 24072001; PMCID: PMC3985753.
  18. Li Q, Atochin D, Kashiwagi S, Earle J, Wang A, Mandeville E, Hayakawa K, d'Uscio LV, Lo EH, Katusic Z, Sessa W, Huang PL. Deficient eNOS phosphorylation is a mechanism for diabetic vascular dysfunction contributing to increased stroke size. Stroke. 2013 Nov; 44(11):3183-8. PMID: 23988642; PMCID: PMC3864831.
  19. Esposito E, Mandeville ET, Hayakawa K, Singhal AB, Lo EH. Effects of normobaric oxygen on the progression of focal cerebral ischemia in rats. Exp Neurol. 2013 Nov; 249:33-8. PMID: 23958492; PMCID: PMC3805377.
  20. Won SY, Schlunk F, Dinkel J, Karatas H, Leung W, Hayakawa K, Lauer A, Steinmetz H, Lo EH, Foerch C, Gupta R. Imaging of contrast medium extravasation in anticoagulation-associated intracerebral hemorrhage with dual-energy computed tomography. Stroke. 2013 Oct; 44(10):2883-90. PMID: 23920016; PMCID: PMC3985727.
  21. Miyamoto N, Pham LD, Hayakawa K, Matsuzaki T, Seo JH, Magnain C, Ayata C, Kim KW, Boas D, Lo EH, Arai K. Age-related decline in oligodendrogenesis retards white matter repair in mice. Stroke. 2013 Sep; 44(9):2573-8. PMID: 23881957; PMCID: PMC3818687.
  22. Maki T, Hayakawa K, Pham LD, Xing C, Lo EH, Arai K. Biphasic mechanisms of neurovascular unit injury and protection in CNS diseases. CNS Neurol Disord Drug Targets. 2013 May 01; 12(3):302-15. PMID: 23469847; PMCID: PMC3845030.
  23. Macaya DJ, Hayakawa K, Arai K, Spector M. Astrocyte infiltration into injectable collagen-based hydrogels containing FGF-2 to treat spinal cord injury. Biomaterials. 2013 May; 34(14):3591-602. PMID: 23414684.
    View in: PubMed
  24. Seo JH, Miyamoto N, Hayakawa K, Pham LD, Maki T, Ayata C, Kim KW, Lo EH, Arai K. Oligodendrocyte precursors induce early blood-brain barrier opening after white matter injury. J Clin Invest. 2013 Feb; 123(2):782-6. PMID: 23281396; PMCID: PMC3561802.
  25. Hayakawa K, Pham LD, Arai K, Lo EH. High-mobility group box 1: an amplifier of stem and progenitor cell activity after stroke. Acta Neurochir Suppl. 2013; 118:31-8. PMID: 23564100; PMCID: PMC3985720.
  26. Hayakawa K, Miyamoto N, Seo JH, Pham LD, Kim KW, Lo EH, Arai K. High-mobility group box 1 from reactive astrocytes enhances the accumulation of endothelial progenitor cells in damaged white matter. J Neurochem. 2013 Apr; 125(2):273-80. PMID: 23227954; PMCID: PMC3604050.
  27. Morimoto N, Kita S, Shimazawa M, Namimatsu H, Tsuruma K, Hayakawa K, Mishima K, Egashira N, Iyoda T, Horie I, Gotoh Y, Iwasaki K, Fujiwara M, Matsuda T, Baba A, Komuro I, Horie K, Takeda J, Iwamoto T, Hara H. Preferential involvement of Na?/Ca²? exchanger type-1 in the brain damage caused by transient focal cerebral ischemia in mice. Biochem Biophys Res Commun. 2012 Dec 14; 429(3-4):186-90. PMID: 23137542.
    View in: PubMed
  28. Higuchi S, Irie K, Yamaguchi R, Katsuki M, Araki M, Ohji M, Hayakawa K, Mishima S, Akitake Y, Matsuyama K, Mishima K, Mishima K, Iwasaki K, Fujiwara M. Hypothalamic 2-arachidonoylglycerol regulates multistage process of high-fat diet preferences. PLoS One. 2012; 7(6):e38609. PMID: 22737214; PMCID: PMC3380864.
  29. Zhao S, Yu Z, Zhao G, Xing C, Hayakawa K, Whalen MJ, Lok JM, Lo EH, Wang X. Neuroglobin-overexpression reduces traumatic brain lesion size in mice. BMC Neurosci. 2012 Jun 15; 13:67. PMID: 22703519; PMCID: PMC3444402.
  30. Xing C, Hayakawa K, Lok J, Arai K, Lo EH. Injury and repair in the neurovascular unit. Neurol Res. 2012 May; 34(4):325-30. PMID: 22643075; PMCID: PMC3985722.
  31. Hayakawa K, Pham LD, Katusic ZS, Arai K, Lo EH. Astrocytic high-mobility group box 1 promotes endothelial progenitor cell-mediated neurovascular remodeling during stroke recovery. Proc Natl Acad Sci U S A. 2012 May 08; 109(19):7505-10. PMID: 22529378; PMCID: PMC3358881.
  32. Pham LD, Hayakawa K, Seo JH, Nguyen MN, Som AT, Lee BJ, Guo S, Kim KW, Lo EH, Arai K. Crosstalk between oligodendrocytes and cerebral endothelium contributes to vascular remodeling after white matter injury. Glia. 2012 May; 60(6):875-81. PMID: 22392631; PMCID: PMC3325331.
  33. Hayakawa K, Seo JH, Pham LD, Miyamoto N, Som AT, Guo S, Kim KW, Lo EH, Arai K. Cerebral endothelial derived vascular endothelial growth factor promotes the migration but not the proliferation of oligodendrocyte precursor cells in vitro. Neurosci Lett. 2012 Mar 28; 513(1):42-6. PMID: 22342913; PMCID: PMC3302953.
  34. Fujioka M, Nakano T, Hayakawa K, Irie K, Akitake Y, Sakamoto Y, Mishima K, Muroi C, Yonekawa Y, Banno F, Kokame K, Miyata T, Nishio K, Okuchi K, Iwasaki K, Fujiwara M, Siesjö BK. ADAMTS13 gene deletion enhances plasma high-mobility group box1 elevation and neuroinflammation in brain ischemia-reperfusion injury. Neurol Sci. 2012 Oct; 33(5):1107-15. PMID: 22212812.
    View in: PubMed
  35. Schlunk F, Van Cott EM, Hayakawa K, Pfeilschifter W, Lo EH, Foerch C. Recombinant activated coagulation factor VII and prothrombin complex concentrates are equally effective in reducing hematoma volume in experimental warfarin-associated intracerebral hemorrhage. Stroke. 2012 Jan; 43(1):246-9. PMID: 21998055; PMCID: PMC3722613.
  36. Hayakawa K, Pham LD, Som AT, Lee BJ, Guo S, Lo EH, Arai K. Vascular endothelial growth factor regulates the migration of oligodendrocyte precursor cells. J Neurosci. 2011 Jul 20; 31(29):10666-70. PMID: 21775609; PMCID: PMC3145205.
  37. Arai K, Lok J, Guo S, Hayakawa K, Xing C, Lo EH. Cellular mechanisms of neurovascular damage and repair after stroke. J Child Neurol. 2011 Sep; 26(9):1193-8. PMID: 21628695; PMCID: PMC3530192.
  38. Navaratna D, Guo SZ, Hayakawa K, Wang X, Gerhardinger C, Lo EH. Decreased cerebrovascular brain-derived neurotrophic factor-mediated neuroprotection in the diabetic brain. Diabetes. 2011 Jun; 60(6):1789-96. PMID: 21562076; PMCID: PMC3114398.
  39. Hayakawa K, Qiu J, Lo EH. Biphasic actions of HMGB1 signaling in inflammation and recovery after stroke. Ann N Y Acad Sci. 2010 Oct; 1207:50-7. PMID: 20955426; PMCID: PMC3705575.
  40. Ishikane S, Yamahara K, Sada M, Harada K, Kodama M, Ishibashi-Ueda H, Hayakawa K, Mishima K, Iwasaki K, Fujiwara M, Kangawa K, Ikeda T. Allogeneic administration of fetal membrane-derived mesenchymal stem cells attenuates acute myocarditis in rats. J Mol Cell Cardiol. 2010 Nov; 49(5):753-61. PMID: 20692268.
    View in: PubMed
  41. Hayakawa K, Mishima K, Fujiwara M. Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke. Pharmaceuticals (Basel). 2010 Jul 08; 3(7):2197-2212. PMID: 27713349.
    View in: PubMed
  42. Hayakawa K, Arai K, Lo EH. Role of ERK map kinase and CRM1 in IL-1beta-stimulated release of HMGB1 from cortical astrocytes. Glia. 2010 Jun; 58(8):1007-15. PMID: 20222144; PMCID: PMC3814180.
  43. Hayakawa K, Nakano T, Irie K, Higuchi S, Fujioka M, Orito K, Iwasaki K, Jin G, Lo EH, Mishima K, Fujiwara M. Inhibition of reactive astrocytes with fluorocitrate retards neurovascular remodeling and recovery after focal cerebral ischemia in mice. J Cereb Blood Flow Metab. 2010 Apr; 30(4):871-82. PMID: 19997116; PMCID: PMC2949171.
  44. Fujioka M, Hayakawa K, Mishima K, Kunizawa A, Irie K, Higuchi S, Nakano T, Muroi C, Fukushima H, Sugimoto M, Banno F, Kokame K, Miyata T, Fujiwara M, Okuchi K, Nishio K. ADAMTS13 gene deletion aggravates ischemic brain damage: a possible neuroprotective role of ADAMTS13 by ameliorating postischemic hypoperfusion. Blood. 2010 Feb 25; 115(8):1650-3. PMID: 19965676.
    View in: PubMed
  45. Hayakawa K, Irie K, Sano K, Watanabe T, Higuchi S, Enoki M, Nakano T, Harada K, Ishikane S, Ikeda T, Fujioka M, Orito K, Iwasaki K, Mishima K, Fujiwara M. Therapeutic time window of cannabidiol treatment on delayed ischemic damage via high-mobility group box1-inhibiting mechanism. Biol Pharm Bull. 2009 Sep; 32(9):1538-44. PMID: 19721229.
    View in: PubMed
  46. Haraguchi T, Takasaki K, Naito T, Hayakawa K, Katsurabayashi S, Mishima K, Iwasaki K, Fujiwara M. Cerebroprotective action of telmisartan by inhibition of macrophages/microglia expressing HMGB1 via a peroxisome proliferator-activated receptor gamma-dependent mechanism. Neurosci Lett. 2009 Oct 30; 464(3):151-5. PMID: 19699780.
    View in: PubMed
  47. Watanabe T, Yamagata N, Takasaki K, Sano K, Hayakawa K, Katsurabayashi S, Egashira N, Mishima K, Iwasaki K, Fujiwara M. Decreased acetylcholine release is correlated to memory impairment in the Tg2576 transgenic mouse model of Alzheimer's disease. Brain Res. 2009 Jan 16; 1249:222-8. PMID: 18996097.
    View in: PubMed
  48. Hayakawa K, Mishima K, Irie K, Hazekawa M, Mishima S, Fujioka M, Orito K, Egashira N, Katsurabayashi S, Takasaki K, Iwasaki K, Fujiwara M. Cannabidiol prevents a post-ischemic injury progressively induced by cerebral ischemia via a high-mobility group box1-inhibiting mechanism. Neuropharmacology. 2008 Dec; 55(8):1280-6. PMID: 18634812.
    View in: PubMed
  49. Egashira N, Iwasaki K, Ishibashi A, Hayakawa K, Okuno R, Abe M, Uchida N, Mishima K, Takasaki K, Nishimura R, Oishi R, Fujiwara M. Repeated administration of Yokukansan inhibits DOI-induced head-twitch response and decreases expression of 5-hydroxytryptamine (5-HT)2A receptors in the prefrontal cortex. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Aug 01; 32(6):1516-20. PMID: 18558456.
    View in: PubMed
  50. Hayakawa K, Mishima K, Nozako M, Hazekawa M, Mishima S, Fujioka M, Orito K, Egashira N, Iwasaki K, Fujiwara M. Delayed treatment with minocycline ameliorates neurologic impairment through activated microglia expressing a high-mobility group box1-inhibiting mechanism. Stroke. 2008 Mar; 39(3):951-8. PMID: 18258837.
    View in: PubMed
  51. Hayakawa K, Mishima K, Hazekawa M, Sano K, Irie K, Orito K, Egawa T, Kitamura Y, Uchida N, Nishimura R, Egashira N, Iwasaki K, Fujiwara M. Cannabidiol potentiates pharmacological effects of Delta(9)-tetrahydrocannabinol via CB(1) receptor-dependent mechanism. Brain Res. 2008 Jan 10; 1188:157-64. PMID: 18021759.
    View in: PubMed
  52. Egashira N, Hayakawa K, Osajima M, Mishima K, Iwasaki K, Oishi R, Fujiwara M. Involvement of GABA(A) receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice. J Pharmacol Sci. 2007 Oct; 105(2):211-4. PMID: 17928735.
    View in: PubMed
  53. Hayakawa K, Mishima K, Nozako M, Hazekawa M, Irie K, Fujioka M, Orito K, Abe K, Hasebe N, Egashira N, Iwasaki K, Fujiwara M. Delayed treatment with cannabidiol has a cerebroprotective action via a cannabinoid receptor-independent myeloperoxidase-inhibiting mechanism. J Neurochem. 2007 Sep; 102(5):1488-96. PMID: 17437545.
    View in: PubMed
  54. Hayakawa K, Mishima K, Nozako M, Ogata A, Hazekawa M, Liu AX, Fujioka M, Abe K, Hasebe N, Egashira N, Iwasaki K, Fujiwara M. Repeated treatment with cannabidiol but not Delta9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance. Neuropharmacology. 2007 Mar; 52(4):1079-87. PMID: 17320118.
    View in: PubMed
  55. Hayakawa K, Mishima K, Nozako M, Hazekawa M, Ogata A, Fujioka M, Harada K, Mishima S, Orito K, Egashira N, Iwasaki K, Fujiwara M. Delta9-tetrahydrocannabinol (Delta9-THC) prevents cerebral infarction via hypothalamic-independent hypothermia. Life Sci. 2007 Mar 27; 80(16):1466-71. PMID: 17289082.
    View in: PubMed
  56. Hayakawa K, Mishima K, Nozako M, Hazekawa M, Aoyama Y, Ogata A, Harada K, Fujioka M, Abe K, Egashira N, Iwasaki K, Fujiwara M. High-cholesterol feeding aggravates cerebral infarction via decreasing the CB1 receptor. Neurosci Lett. 2007 Mar 06; 414(2):183-7. PMID: 17208374.
    View in: PubMed
  57. Mishima K, Hayakawa K, Abe K, Ikeda T, Egashira N, Iwasaki K, Fujiwara M. Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism. Stroke. 2005 May; 36(5):1077-82. PMID: 15845890.
    View in: PubMed
  58. Hayakawa K, Mishima K, Abe K, Hasebe N, Takamatsu F, Yasuda H, Ikeda T, Inui K, Egashira N, Iwasaki K, Fujiwara M. Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism. Neuroreport. 2004 Oct 25; 15(15):2381-5. PMID: 15640760.
    View in: PubMed
  59. Egashira N, Hayakawa K, Mishima K, Kimura H, Iwasaki K, Fujiwara M. Neuroprotective effect of gamma-glutamylethylamide (theanine) on cerebral infarction in mice. Neurosci Lett. 2004 Jun 03; 363(1):58-61. PMID: 15157996.
    View in: PubMed
  60. Inui K, Egashira N, Mishima K, Yano A, Matsumoto Y, Hasebe N, Abe K, Hayakawa K, Ikeda T, Iwasaki K, Fujiwara M. The serotonin1A receptor agonist 8-OHDPAT reverses delta 9-tetrahydrocannabinol-induced impairment of spatial memory and reduction of acetylcholine release in the dorsal hippocampus in rats. Neurotox Res. 2004; 6(2):153-8. PMID: 15325968.
    View in: PubMed
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