Harvard Catalyst Profiles

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Kazuhide Hayakawa, Ph.D.

Title
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Department
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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS099620 (LO, ENG H.) Sep 1, 2016 - May 31, 2021
    NIH/NINDS
    Inflammatory Mechanisms of Brain - Lymphatic Signaling in Stroke
    Role: Principal Investigator
  2. R01NS094756 (HAYAKAWA, KAZUHIDE) Sep 1, 2015 - May 31, 2020
    NIH/NINDS
    Promotion of neurovascular remodeling through mitochondria transfer after stroke
    Role: Principal Investigator
  3. K99NS080991 (HAYAKAWA, KAZUHIDE) Dec 1, 2012 - Nov 30, 2014
    NIH/NINDS
    CD200 as a monocyte/macrophage switch for brain repair after stroke
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Huang L, Nakamura Y, Lo EH, Hayakawa K. Astrocyte Signaling in the Neurovascular Unit After Central Nervous System Injury. Int J Mol Sci. 2019 Jan 11; 20(2). PMID: 30642007.
    Citations:    Fields:    
  2. Chan SJ, Zhao H, Hayakawa K, Chai C, Tan CT, Huang J, Tao R, Hamanaka G, Arumugam TV, Lo EH, Yu VCK, Wong PH. Modulator of apoptosis-1 is a potential therapeutic target in acute ischemic injury. J Cereb Blood Flow Metab. 2018 Aug 22; 271678X18794839. PMID: 30132384.
    Citations:    Fields:    
  3. Hayakawa K, Chan SJ, Mandeville ET, Park JH, Bruzzese M, Montaner J, Arai K, Rosell A, Lo EH. Protective Effects of Endothelial Progenitor Cell-Derived Extracellular Mitochondria in Brain Endothelium. Stem Cells. 2018 Sep; 36(9):1404-1410. PMID: 29781122.
    Citations: 3     Fields:    
  4. Esposito E, Hayakawa K, Ahn BJ, Chan SJ, Xing C, Liang AC, Kim KW, Arai K, Lo EH. Effects of ischemic post-conditioning on neuronal VEGF regulation and microglial polarization in a rat model of focal cerebral ischemia. J Neurochem. 2018 07; 146(2):160-172. PMID: 29570780.
    Citations: 1     Fields:    
  5. Maki T, Morancho A, Martinez-San Segundo P, Hayakawa K, Takase H, Liang AC, Gabriel-Salazar M, Medina-Gutiérrez E, Washida K, Montaner J, Lok J, Lo EH, Arai K, Rosell A. Endothelial Progenitor Cell Secretome and Oligovascular Repair in a Mouse Model of Prolonged Cerebral Hypoperfusion. Stroke. 2018 04; 49(4):1003-1010. PMID: 29511131.
    Citations: 5     Fields:    
  6. Hayakawa K, Bruzzese M, Chou SH, Ning M, Ji X, Lo EH. Extracellular Mitochondria for Therapy and Diagnosis in Acute Central Nervous System Injury. JAMA Neurol. 2018 Jan 01; 75(1):119-122. PMID: 29159397.
    Citations: 2     Fields:    
  7. Chou SH, Lan J, Esposito E, Ning M, Balaj L, Ji X, Lo EH, Hayakawa K. Extracellular Mitochondria in Cerebrospinal Fluid and Neurological Recovery After Subarachnoid Hemorrhage. Stroke. 2017 08; 48(8):2231-2237. PMID: 28663512.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  8. Takase H, Washida K, Hayakawa K, Arai K, Wang X, Lo EH, Lok J. Oligodendrogenesis after traumatic brain injury. Behav Brain Res. 2018 03 15; 340:205-211. PMID: 27829126.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  9. Xing C, Hayakawa K, Lo EH. Mechanisms, Imaging, and Therapy in Stroke Recovery. Transl Stroke Res. 2017 02; 8(1):1-2. PMID: 27714670.
    Citations: 4     Fields:    Translation:Humans
  10. Choi YK, Maki T, Mandeville ET, Koh SH, Hayakawa K, Arai K, Kim YM, Whalen MJ, Xing C, Wang X, Kim KW, Lo EH. Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury. Nat Med. 2016 11; 22(11):1335-1341. PMID: 27668935.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  11. Hayakawa K, Esposito E, Wang X, Terasaki Y, Liu Y, Xing C, Ji X, Lo EH. Transfer of mitochondria from astrocytes to neurons after stroke. Nature. 2016 07 28; 535(7613):551-5. PMID: 27466127.
    Citations: 71     Fields:    Translation:AnimalsCells
  12. Guo S, Lok J, Zhao S, Leung W, Som AT, Hayakawa K, Wang Q, Xing C, Wang X, Ji X, Zhou Y, Lo EH. Effects of Controlled Cortical Impact on the Mouse Brain Vasculome. J Neurotrauma. 2016 07 15; 33(14):1303-16. PMID: 26528928.
    Citations: 1     Fields:    Translation:AnimalsCells
  13. Hayakawa K, Wang X, Lo EH. CD200 increases alternatively activated macrophages through cAMP-response element binding protein - C/EBP-beta signaling. J Neurochem. 2016 Mar; 136(5):900-6. PMID: 26670206.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  14. Hayakawa K, Pham LD, Seo JH, Miyamoto N, Maki T, Terasaki Y, Sakadžic S, Boas D, van Leyen K, Waeber C, Kim KW, Arai K, Lo EH. CD200 restrains macrophage attack on oligodendrocyte precursors via toll-like receptor 4 downregulation. J Cereb Blood Flow Metab. 2016 Apr; 36(4):781-93. PMID: 26661156.
    Citations: 6     Fields:    Translation:AnimalsCells
  15. Hayakawa K, Lo EH. Brain-peripheral cell crosstalk in white matter damage and repair. Biochim Biophys Acta. 2016 05; 1862(5):901-8. PMID: 26277436.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  16. Nakano T, Irie K, Hayakawa K, Sano K, Nakamura Y, Tanaka M, Yamashita Y, Satho T, Fujioka M, Muroi C, Matsuo K, Ishikura H, Futagami K, Mishima K. Delayed treatment with ADAMTS13 ameliorates cerebral ischemic injury without hemorrhagic complication. Brain Res. 2015 Oct 22; 1624:330-335. PMID: 26254727.
    Citations: 3     Fields:    Translation:Animals
  17. Esposito E, Hayakawa K, Maki T, Arai K, Lo EH. Effects of Postconditioning on Neurogenesis and Angiogenesis During the Recovery Phase After Focal Cerebral Ischemia. Stroke. 2015 Sep; 46(9):2691-4. PMID: 26243221.
    Citations: 9     Fields:    Translation:Animals
  18. Seo JH, Maki T, Maeda M, Miyamoto N, Liang AC, Hayakawa K, Pham LD, Suwa F, Taguchi A, Matsuyama T, Ihara M, Kim KW, Lo EH, Arai K. Oligodendrocyte precursor cells support blood-brain barrier integrity via TGF-ß signaling. PLoS One. 2014; 9(7):e103174. PMID: 25078775.
    Citations: 29     Fields:    Translation:AnimalsCells
  19. Guo S, Lok J, Liu Y, Hayakawa K, Leung W, Xing C, Ji X, Lo EH. Assays to examine endothelial cell migration, tube formation, and gene expression profiles. Methods Mol Biol. 2014; 1135:393-402. PMID: 24510881.
    Citations: 2     Fields:    Translation:AnimalsCells
  20. Terasaki Y, Liu Y, Hayakawa K, Pham LD, Lo EH, Ji X, Arai K. Mechanisms of neurovascular dysfunction in acute ischemic brain. Curr Med Chem. 2014; 21(18):2035-42. PMID: 24372202.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  21. Hayakawa K, Pham LD, Arai K, Lo EH. Reactive astrocytes promote adhesive interactions between brain endothelium and endothelial progenitor cells via HMGB1 and beta-2 integrin signaling. Stem Cell Res. 2014 Mar; 12(2):531-8. PMID: 24480450.
    Citations: 5     Fields:    Translation:AnimalsCells
  22. Miyamoto N, Maki T, Pham LD, Hayakawa K, Seo JH, Mandeville ET, Mandeville JB, Kim KW, Lo EH, Arai K. Oxidative stress interferes with white matter renewal after prolonged cerebral hypoperfusion in mice. Stroke. 2013 Dec; 44(12):3516-21. PMID: 24072001.
    Citations: 36     Fields:    Translation:AnimalsCells
  23. Li Q, Atochin D, Kashiwagi S, Earle J, Wang A, Mandeville E, Hayakawa K, d'Uscio LV, Lo EH, Katusic Z, Sessa W, Huang PL. Deficient eNOS phosphorylation is a mechanism for diabetic vascular dysfunction contributing to increased stroke size. Stroke. 2013 Nov; 44(11):3183-8. PMID: 23988642.
    Citations: 15     Fields:    Translation:AnimalsCells
  24. Esposito E, Mandeville ET, Hayakawa K, Singhal AB, Lo EH. Effects of normobaric oxygen on the progression of focal cerebral ischemia in rats. Exp Neurol. 2013 Nov; 249:33-8. PMID: 23958492.
    Citations: 8     Fields:    Translation:Animals
  25. Won SY, Schlunk F, Dinkel J, Karatas H, Leung W, Hayakawa K, Lauer A, Steinmetz H, Lo EH, Foerch C, Gupta R. Imaging of contrast medium extravasation in anticoagulation-associated intracerebral hemorrhage with dual-energy computed tomography. Stroke. 2013 Oct; 44(10):2883-90. PMID: 23920016.
    Citations: 5     Fields:    Translation:Animals
  26. Miyamoto N, Pham LD, Hayakawa K, Matsuzaki T, Seo JH, Magnain C, Ayata C, Kim KW, Boas D, Lo EH, Arai K. Age-related decline in oligodendrogenesis retards white matter repair in mice. Stroke. 2013 Sep; 44(9):2573-8. PMID: 23881957.
    Citations: 25     Fields:    Translation:AnimalsCells
  27. Maki T, Hayakawa K, Pham LD, Xing C, Lo EH, Arai K. Biphasic mechanisms of neurovascular unit injury and protection in CNS diseases. CNS Neurol Disord Drug Targets. 2013 May 01; 12(3):302-15. PMID: 23469847.
    Citations: 26     Fields:    Translation:HumansCells
  28. Macaya DJ, Hayakawa K, Arai K, Spector M. Astrocyte infiltration into injectable collagen-based hydrogels containing FGF-2 to treat spinal cord injury. Biomaterials. 2013 May; 34(14):3591-602. PMID: 23414684.
    Citations: 11     Fields:    Translation:AnimalsCells
  29. Seo JH, Miyamoto N, Hayakawa K, Pham LD, Maki T, Ayata C, Kim KW, Lo EH, Arai K. Oligodendrocyte precursors induce early blood-brain barrier opening after white matter injury. J Clin Invest. 2013 Feb; 123(2):782-6. PMID: 23281396.
    Citations: 39     Fields:    Translation:AnimalsCells
  30. Hayakawa K, Pham LD, Arai K, Lo EH. High-mobility group box 1: an amplifier of stem and progenitor cell activity after stroke. Acta Neurochir Suppl. 2013; 118:31-8. PMID: 23564100.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  31. Hayakawa K, Miyamoto N, Seo JH, Pham LD, Kim KW, Lo EH, Arai K. High-mobility group box 1 from reactive astrocytes enhances the accumulation of endothelial progenitor cells in damaged white matter. J Neurochem. 2013 Apr; 125(2):273-80. PMID: 23227954.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  32. Morimoto N, Kita S, Shimazawa M, Namimatsu H, Tsuruma K, Hayakawa K, Mishima K, Egashira N, Iyoda T, Horie I, Gotoh Y, Iwasaki K, Fujiwara M, Matsuda T, Baba A, Komuro I, Horie K, Takeda J, Iwamoto T, Hara H. Preferential involvement of Na?/Ca²? exchanger type-1 in the brain damage caused by transient focal cerebral ischemia in mice. Biochem Biophys Res Commun. 2012 Dec 14; 429(3-4):186-90. PMID: 23137542.
    Citations: 3     Fields:    Translation:Animals
  33. Higuchi S, Irie K, Yamaguchi R, Katsuki M, Araki M, Ohji M, Hayakawa K, Mishima S, Akitake Y, Matsuyama K, Mishima K, Mishima K, Iwasaki K, Fujiwara M. Hypothalamic 2-arachidonoylglycerol regulates multistage process of high-fat diet preferences. PLoS One. 2012; 7(6):e38609. PMID: 22737214.
    Citations: 8     Fields:    Translation:AnimalsCells
  34. Zhao S, Yu Z, Zhao G, Xing C, Hayakawa K, Whalen MJ, Lok JM, Lo EH, Wang X. Neuroglobin-overexpression reduces traumatic brain lesion size in mice. BMC Neurosci. 2012 Jun 15; 13:67. PMID: 22703519.
    Citations: 11     Fields:    Translation:Animals
  35. Xing C, Hayakawa K, Lok J, Arai K, Lo EH. Injury and repair in the neurovascular unit. Neurol Res. 2012 May; 34(4):325-30. PMID: 22643075.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  36. Hayakawa K, Pham LD, Katusic ZS, Arai K, Lo EH. Astrocytic high-mobility group box 1 promotes endothelial progenitor cell-mediated neurovascular remodeling during stroke recovery. Proc Natl Acad Sci U S A. 2012 May 08; 109(19):7505-10. PMID: 22529378.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  37. Pham LD, Hayakawa K, Seo JH, Nguyen MN, Som AT, Lee BJ, Guo S, Kim KW, Lo EH, Arai K. Crosstalk between oligodendrocytes and cerebral endothelium contributes to vascular remodeling after white matter injury. Glia. 2012 May; 60(6):875-81. PMID: 22392631.
    Citations: 38     Fields:    Translation:AnimalsCells
  38. Hayakawa K, Seo JH, Pham LD, Miyamoto N, Som AT, Guo S, Kim KW, Lo EH, Arai K. Cerebral endothelial derived vascular endothelial growth factor promotes the migration but not the proliferation of oligodendrocyte precursor cells in vitro. Neurosci Lett. 2012 Mar 28; 513(1):42-6. PMID: 22342913.
    Citations: 16     Fields:    Translation:AnimalsCells
  39. Fujioka M, Nakano T, Hayakawa K, Irie K, Akitake Y, Sakamoto Y, Mishima K, Muroi C, Yonekawa Y, Banno F, Kokame K, Miyata T, Nishio K, Okuchi K, Iwasaki K, Fujiwara M, Siesjö BK. ADAMTS13 gene deletion enhances plasma high-mobility group box1 elevation and neuroinflammation in brain ischemia-reperfusion injury. Neurol Sci. 2012 Oct; 33(5):1107-15. PMID: 22212812.
    Citations: 9     Fields:    Translation:Animals
  40. Schlunk F, Van Cott EM, Hayakawa K, Pfeilschifter W, Lo EH, Foerch C. Recombinant activated coagulation factor VII and prothrombin complex concentrates are equally effective in reducing hematoma volume in experimental warfarin-associated intracerebral hemorrhage. Stroke. 2012 Jan; 43(1):246-9. PMID: 21998055.
    Citations: 9     Fields:    Translation:Animals
  41. Hayakawa K, Pham LD, Som AT, Lee BJ, Guo S, Lo EH, Arai K. Vascular endothelial growth factor regulates the migration of oligodendrocyte precursor cells. J Neurosci. 2011 Jul 20; 31(29):10666-70. PMID: 21775609.
    Citations: 38     Fields:    Translation:AnimalsCells
  42. Arai K, Lok J, Guo S, Hayakawa K, Xing C, Lo EH. Cellular mechanisms of neurovascular damage and repair after stroke. J Child Neurol. 2011 Sep; 26(9):1193-8. PMID: 21628695.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  43. Navaratna D, Guo SZ, Hayakawa K, Wang X, Gerhardinger C, Lo EH. Decreased cerebrovascular brain-derived neurotrophic factor-mediated neuroprotection in the diabetic brain. Diabetes. 2011 Jun; 60(6):1789-96. PMID: 21562076.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  44. Hayakawa K, Qiu J, Lo EH. Biphasic actions of HMGB1 signaling in inflammation and recovery after stroke. Ann N Y Acad Sci. 2010 Oct; 1207:50-7. PMID: 20955426.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  45. Ishikane S, Yamahara K, Sada M, Harada K, Kodama M, Ishibashi-Ueda H, Hayakawa K, Mishima K, Iwasaki K, Fujiwara M, Kangawa K, Ikeda T. Allogeneic administration of fetal membrane-derived mesenchymal stem cells attenuates acute myocarditis in rats. J Mol Cell Cardiol. 2010 Nov; 49(5):753-61. PMID: 20692268.
    Citations: 7     Fields:    Translation:AnimalsCells
  46. Hayakawa K, Mishima K, Fujiwara M. Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke. Pharmaceuticals (Basel). 2010 Jul 08; 3(7):2197-2212. PMID: 27713349.
    Citations: 3     
  47. Hayakawa K, Arai K, Lo EH. Role of ERK map kinase and CRM1 in IL-1beta-stimulated release of HMGB1 from cortical astrocytes. Glia. 2010 Jun; 58(8):1007-15. PMID: 20222144.
    Citations: 24     Fields:    Translation:AnimalsCells
  48. Hayakawa K, Nakano T, Irie K, Higuchi S, Fujioka M, Orito K, Iwasaki K, Jin G, Lo EH, Mishima K, Fujiwara M. Inhibition of reactive astrocytes with fluorocitrate retards neurovascular remodeling and recovery after focal cerebral ischemia in mice. J Cereb Blood Flow Metab. 2010 Apr; 30(4):871-82. PMID: 19997116.
    Citations: 46     Fields:    Translation:AnimalsCells
  49. Fujioka M, Hayakawa K, Mishima K, Kunizawa A, Irie K, Higuchi S, Nakano T, Muroi C, Fukushima H, Sugimoto M, Banno F, Kokame K, Miyata T, Fujiwara M, Okuchi K, Nishio K. ADAMTS13 gene deletion aggravates ischemic brain damage: a possible neuroprotective role of ADAMTS13 by ameliorating postischemic hypoperfusion. Blood. 2010 Feb 25; 115(8):1650-3. PMID: 19965676.
    Citations: 28     Fields:    Translation:Animals
  50. Hayakawa K, Irie K, Sano K, Watanabe T, Higuchi S, Enoki M, Nakano T, Harada K, Ishikane S, Ikeda T, Fujioka M, Orito K, Iwasaki K, Mishima K, Fujiwara M. Therapeutic time window of cannabidiol treatment on delayed ischemic damage via high-mobility group box1-inhibiting mechanism. Biol Pharm Bull. 2009 Sep; 32(9):1538-44. PMID: 19721229.
    Citations: 8     Fields:    Translation:Animals
  51. Haraguchi T, Takasaki K, Naito T, Hayakawa K, Katsurabayashi S, Mishima K, Iwasaki K, Fujiwara M. Cerebroprotective action of telmisartan by inhibition of macrophages/microglia expressing HMGB1 via a peroxisome proliferator-activated receptor gamma-dependent mechanism. Neurosci Lett. 2009 Oct 30; 464(3):151-5. PMID: 19699780.
    Citations: 8     Fields:    Translation:AnimalsCells
  52. Watanabe T, Yamagata N, Takasaki K, Sano K, Hayakawa K, Katsurabayashi S, Egashira N, Mishima K, Iwasaki K, Fujiwara M. Decreased acetylcholine release is correlated to memory impairment in the Tg2576 transgenic mouse model of Alzheimer's disease. Brain Res. 2009 Jan 16; 1249:222-8. PMID: 18996097.
    Citations: 13     Fields:    Translation:Animals
  53. Hayakawa K, Mishima K, Irie K, Hazekawa M, Mishima S, Fujioka M, Orito K, Egashira N, Katsurabayashi S, Takasaki K, Iwasaki K, Fujiwara M. Cannabidiol prevents a post-ischemic injury progressively induced by cerebral ischemia via a high-mobility group box1-inhibiting mechanism. Neuropharmacology. 2008 Dec; 55(8):1280-6. PMID: 18634812.
    Citations: 21     Fields:    Translation:Animals
  54. Egashira N, Iwasaki K, Ishibashi A, Hayakawa K, Okuno R, Abe M, Uchida N, Mishima K, Takasaki K, Nishimura R, Oishi R, Fujiwara M. Repeated administration of Yokukansan inhibits DOI-induced head-twitch response and decreases expression of 5-hydroxytryptamine (5-HT)2A receptors in the prefrontal cortex. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Aug 01; 32(6):1516-20. PMID: 18558456.
    Citations: 20     Fields:    Translation:Animals
  55. Hayakawa K, Mishima K, Nozako M, Hazekawa M, Mishima S, Fujioka M, Orito K, Egashira N, Iwasaki K, Fujiwara M. Delayed treatment with minocycline ameliorates neurologic impairment through activated microglia expressing a high-mobility group box1-inhibiting mechanism. Stroke. 2008 Mar; 39(3):951-8. PMID: 18258837.
    Citations: 36     Fields:    Translation:AnimalsCells
  56. Hayakawa K, Mishima K, Hazekawa M, Sano K, Irie K, Orito K, Egawa T, Kitamura Y, Uchida N, Nishimura R, Egashira N, Iwasaki K, Fujiwara M. Cannabidiol potentiates pharmacological effects of Delta(9)-tetrahydrocannabinol via CB(1) receptor-dependent mechanism. Brain Res. 2008 Jan 10; 1188:157-64. PMID: 18021759.
    Citations: 27     Fields:    Translation:Animals
  57. Egashira N, Hayakawa K, Osajima M, Mishima K, Iwasaki K, Oishi R, Fujiwara M. Involvement of GABA(A) receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice. J Pharmacol Sci. 2007 Oct; 105(2):211-4. PMID: 17928735.
    Citations: 7     Fields:    Translation:Animals
  58. Hayakawa K, Mishima K, Nozako M, Hazekawa M, Irie K, Fujioka M, Orito K, Abe K, Hasebe N, Egashira N, Iwasaki K, Fujiwara M. Delayed treatment with cannabidiol has a cerebroprotective action via a cannabinoid receptor-independent myeloperoxidase-inhibiting mechanism. J Neurochem. 2007 Sep; 102(5):1488-1496. PMID: 17437545.
    Citations: 22     Fields:    Translation:Animals
  59. Hayakawa K, Mishima K, Nozako M, Ogata A, Hazekawa M, Liu AX, Fujioka M, Abe K, Hasebe N, Egashira N, Iwasaki K, Fujiwara M. Repeated treatment with cannabidiol but not Delta9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance. Neuropharmacology. 2007 Mar; 52(4):1079-87. PMID: 17320118.
    Citations: 21     Fields:    Translation:Animals
  60. Hayakawa K, Mishima K, Nozako M, Hazekawa M, Ogata A, Fujioka M, Harada K, Mishima S, Orito K, Egashira N, Iwasaki K, Fujiwara M. Delta9-tetrahydrocannabinol (Delta9-THC) prevents cerebral infarction via hypothalamic-independent hypothermia. Life Sci. 2007 Mar 27; 80(16):1466-71. PMID: 17289082.
    Citations: 10     Fields:    Translation:Animals
  61. Hayakawa K, Mishima K, Nozako M, Hazekawa M, Aoyama Y, Ogata A, Harada K, Fujioka M, Abe K, Egashira N, Iwasaki K, Fujiwara M. High-cholesterol feeding aggravates cerebral infarction via decreasing the CB1 receptor. Neurosci Lett. 2007 Mar 06; 414(2):183-7. PMID: 17208374.
    Citations: 5     Fields:    Translation:AnimalsCells
  62. Mishima K, Hayakawa K, Abe K, Ikeda T, Egashira N, Iwasaki K, Fujiwara M. Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism. Stroke. 2005 May; 36(5):1077-82. PMID: 15845890.
    Citations: 48     Fields:    Translation:Animals
  63. Hayakawa K, Mishima K, Abe K, Hasebe N, Takamatsu F, Yasuda H, Ikeda T, Inui K, Egashira N, Iwasaki K, Fujiwara M. Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism. Neuroreport. 2004 Oct 25; 15(15):2381-5. PMID: 15640760.
    Citations: 23     Fields:    Translation:Animals
  64. Egashira N, Hayakawa K, Mishima K, Kimura H, Iwasaki K, Fujiwara M. Neuroprotective effect of gamma-glutamylethylamide (theanine) on cerebral infarction in mice. Neurosci Lett. 2004 Jun 03; 363(1):58-61. PMID: 15157996.
    Citations: 4     Fields:    Translation:Animals
  65. Inui K, Egashira N, Mishima K, Yano A, Matsumoto Y, Hasebe N, Abe K, Hayakawa K, Ikeda T, Iwasaki K, Fujiwara M. The serotonin1A receptor agonist 8-OHDPAT reverses delta 9-tetrahydrocannabinol-induced impairment of spatial memory and reduction of acetylcholine release in the dorsal hippocampus in rats. Neurotox Res. 2004; 6(2):153-8. PMID: 15325968.
    Citations: 9     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.