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Junying Yuan, Ph.D.


Elucidating the Role of PIPHD34, A Novel Murine PhD Zinc Finger-Containing Protein, in the Regulationof Apoptosis
Summer, 06/20/01 - 08/31/01
Role of PIPHD34, A Novel Murine PHD Zinc Protein, in the Regulation of Apoptosis
Part Time/Continuation, 09/20/01 - 06/01/02

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AG059073 (YUAN, JUNYING) Mar 15, 2018 - Feb 29, 2020
    Investigating the role and mechanism of RIPK1 in mediating cerebrovascular pathology of AD
    Role: Principal Investigator
  2. RF1AG055521 (YUAN, JUNYING) Sep 15, 2017 - Jun 30, 2022
    Single cell RNA-seq analyses of age-related changes in glial cells and in AD
    Role: Principal Investigator
  3. R01AG047231 (YUAN, JUNYING) May 15, 2014 - Apr 30, 2019
    Investigating the neuroinflammatory role of RIP1 kinase
    Role: Principal Investigator
  4. R01NS082257 (YUAN, JUNYING) Sep 15, 2013 - May 31, 2018
    Investigating the mechanism of TNFalpha mediated cell death in oligodendrocytes
    Role: Principal Investigator
  5. R01CA138961 (YUAN, JUNYING) Jul 17, 2009 - Jun 30, 2012
    Molecular mechanism of a cellular necrotic cell death pathway
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Yuan J, Amin P, Ofengeim D. Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases. Nat Rev Neurosci. 2019 01; 20(1):19-33. PMID: 30467385.
    Citations:    Fields:    
  2. Hitomi J, Christofferson DE, Ng A, Yao J, Degterev A, Xavier RJ, Yuan J. Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell. 2008 Dec 26; 135(7):1311-23. PMID: 19109899.
    Citations: 324     Fields:    Translation:HumansAnimalsCells
  3. Bryant KF, Macari ER, Malik N, Boyce M, Yuan J, Coen DM. ICP34.5-dependent and -independent activities of salubrinal in herpes simplex virus-1 infected cells. Virology. 2008 Sep 30; 379(2):197-204. PMID: 18684481.
    Citations: 9     Fields:    Translation:AnimalsCells
  4. Zhu J, Blenis J, Yuan J. Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1. Proc Natl Acad Sci U S A. 2008 May 06; 105(18):6584-9. PMID: 18451027.
    Citations: 64     Fields:    Translation:HumansCells
  5. Teng X, Keys H, Yuan J, Degterev A, Cuny GD. Structure-activity relationship and liver microsome stability studies of pyrrole necroptosis inhibitors. Bioorg Med Chem Lett. 2008 Jun 01; 18(11):3219-23. PMID: 18467094.
    Citations: 6     Fields:    Translation:HumansCells
  6. Li J, Yin HL, Yuan J. Flightless-I regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity. J Cell Biol. 2008 Apr 21; 181(2):321-33. PMID: 18411310.
    Citations: 23     Fields:    Translation:AnimalsCells
  7. Yuan J. Inducing autophagy harmlessly. Autophagy. 2008 Feb; 4(2):249-50. PMID: 18094626.
    Citations: 1     Fields:    Translation:HumansAnimals
  8. Xu L, Zhu J, Hu X, Zhu H, Kim HT, LaBaer J, Goldberg A, Yuan J. c-IAP1 cooperates with Myc by acting as a ubiquitin ligase for Mad1. Mol Cell. 2007 Dec 14; 28(5):914-22. PMID: 18082613.
    Citations: 31     Fields:    Translation:HumansCells
  9. Sanchez-Olea R, Yuan J. To kill or to arrest: that is the new question for Apaf-1. Mol Cell. 2007 Nov 30; 28(4):520-1. PMID: 18042448.
    Citations:    Fields:    Translation:HumansAnimals
  10. Yi CH, Sogah DK, Boyce M, Degterev A, Christofferson DE, Yuan J. A genome-wide RNAi screen reveals multiple regulators of caspase activation. J Cell Biol. 2007 Nov 19; 179(4):619-26. PMID: 17998402.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  11. Teng X, Keys H, Jeevanandam A, Porco JA, Degterev A, Yuan J, Cuny GD. Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors. Bioorg Med Chem Lett. 2007 Dec 15; 17(24):6836-40. PMID: 17964153.
    Citations: 10     Fields:    Translation:HumansCells
  12. Py BF, Lipinski MM, Yuan J. Autophagy limits Listeria monocytogenes intracellular growth in the early phase of primary infection. Autophagy. 2007 Mar-Apr; 3(2):117-25. PMID: 17204850.
    Citations: 80     Fields:    Translation:AnimalsCells
  13. Jagtap PG, Degterev A, Choi S, Keys H, Yuan J, Cuny GD. Structure-activity relationship study of tricyclic necroptosis inhibitors. J Med Chem. 2007 Apr 19; 50(8):1886-95. PMID: 17361994.
    Citations: 17     Fields:    Translation:HumansCells
  14. Li J, Brieher WM, Scimone ML, Kang SJ, Zhu H, Yin H, von Andrian UH, Mitchison T, Yuan J. Caspase-11 regulates cell migration by promoting Aip1-Cofilin-mediated actin depolymerization. Nat Cell Biol. 2007 Mar; 9(3):276-86. PMID: 17293856.
    Citations: 51     Fields:    Translation:AnimalsCells
  15. Zhang Y, Zhou X, Degterev A, Lipinski M, Adjeroh D, Yuan J, Wong ST. Automated neurite extraction using dynamic programming for high-throughput screening of neuron-based assays. Neuroimage. 2007 May 01; 35(4):1502-15. PMID: 17363284.
    Citations: 22     Fields:    Translation:Cells
  16. Moerke NJ, Aktas H, Chen H, Cantel S, Reibarkh MY, Fahmy A, Gross JD, Degterev A, Yuan J, Chorev M, Halperin JA, Wagner G. Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G. Cell. 2007 Jan 26; 128(2):257-67. PMID: 17254965.
    Citations: 167     Fields:    Translation:HumansAnimalsCells
  17. Stegh AH, Kim H, Bachoo RM, Forloney KL, Zhang J, Schulze H, Park K, Hannon GJ, Yuan J, Louis DN, DePinho RA, Chin L. Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma. Genes Dev. 2007 Jan 01; 21(1):98-111. PMID: 17210792.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  18. Zhang Y, Zhou X, Degterev A, Lipinski M, Adjeroh D, Yuan J, Wong ST. A novel tracing algorithm for high throughput imaging Screening of neuron-based assays. J Neurosci Methods. 2007 Feb 15; 160(1):149-62. PMID: 16987551.
    Citations: 20     Fields:    Translation:AnimalsCellsPHPublic Health
  19. Yuan J. Divergence from a dedicated cellular suicide mechanism: exploring the evolution of cell death. Mol Cell. 2006 Jul 07; 23(1):1-12. PMID: 16818228.
    Citations: 20     Fields:    Translation:HumansAnimals
  20. Matsui T, Ramasamy K, Ingelsson M, Fukumoto H, Conrad C, Frosch MP, Irizarry MC, Yuan J, Hyman BT. Coordinated expression of caspase 8, 3 and 7 mRNA in temporal cortex of Alzheimer disease: relationship to formic acid extractable abeta42 levels. J Neuropathol Exp Neurol. 2006 May; 65(5):508-15. PMID: 16772874.
    Citations: 16     Fields:    Translation:Humans
  21. Shibata M, Lu T, Furuya T, Degterev A, Mizushima N, Yoshimori T, MacDonald M, Yankner B, Yuan J. Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J Biol Chem. 2006 May 19; 281(20):14474-85. PMID: 16522639.
    Citations: 152     Fields:    Translation:HumansAnimals
  22. Yoo LI, Liu DW, Le Vu S, Bronson RT, Wu H, Yuan J. Pten deficiency activates distinct downstream signaling pathways in a tissue-specific manner. Cancer Res. 2006 Feb 15; 66(4):1929-39. PMID: 16488991.
    Citations: 29     Fields:    Translation:AnimalsCells
  23. Teng X, Degterev A, Jagtap P, Xing X, Choi S, Denu R, Yuan J, Cuny GD. Structure-activity relationship study of novel necroptosis inhibitors. Bioorg Med Chem Lett. 2005 Nov 15; 15(22):5039-44. PMID: 16153840.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  24. Lipinski MM, Yuan J. A cellular response to an internal energy crisis. Cell. 2005 Oct 07; 123(1):3-5. PMID: 16213206.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  25. Gozani O, Field SJ, Ferguson CG, Ewalt M, Mahlke C, Cantley LC, Prestwich GD, Yuan J. Modification of protein sub-nuclear localization by synthetic phosphoinositides: evidence for nuclear phosphoinositide signaling mechanisms. Adv Enzyme Regul. 2005; 45:171-85. PMID: 16199078.
    Citations: 6     Fields:    Translation:AnimalsCells
  26. Elkin SK, Ivanov D, Ewalt M, Ferguson CG, Hyberts SG, Sun ZY, Prestwich GD, Yuan J, Wagner G, Oettinger MA, Gozani OP. A PHD finger motif in the C terminus of RAG2 modulates recombination activity. J Biol Chem. 2005 Aug 05; 280(31):28701-10. PMID: 15964836.
    Citations: 27     Fields:    Translation:AnimalsCells
  27. Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N, Cuny GD, Mitchison TJ, Moskowitz MA, Yuan J. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol. 2005 Jul; 1(2):112-9. PMID: 16408008.
    Citations: 634     Fields:    Translation:HumansAnimalsCells
  28. Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, Kaufman RJ, Ma D, Coen DM, Ron D, Yuan J. A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science. 2005 Feb 11; 307(5711):935-9. PMID: 15705855.
    Citations: 448     Fields:    Translation:AnimalsCells
  29. Kang SJ, Popat R, Bragdon C, Odonnell K, Phelan S, Yuan J, Sonis ST. Caspase-11 is not necessary for chemotherapy-induced intestinal mucositis. DNA Cell Biol. 2004 Aug; 23(8):490-5. PMID: 15307951.
    Citations: 4     Fields:    Translation:Animals
  30. Terui Y, Saad N, Jia S, McKeon F, Yuan J. Dual role of sumoylation in the nuclear localization and transcriptional activation of NFAT1. J Biol Chem. 2004 Jul 02; 279(27):28257-65. PMID: 15117942.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  31. Qiu XB, Markant SL, Yuan J, Goldberg AL. Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis. EMBO J. 2004 Feb 25; 23(4):800-10. PMID: 14765125.
    Citations: 44     Fields:    Translation:HumansCells
  32. Lipinski MM, Yuan J. Mechanisms of cell death in polyglutamine expansion diseases. Curr Opin Pharmacol. 2004 Feb; 4(1):85-90. PMID: 15018844.
    Citations: 13     Fields:    Translation:Animals
  33. Yuan J, Horvitz HR. A first insight into the molecular mechanisms of apoptosis. Cell. 2004 Jan 23; 116(2 Suppl):S53-6, 1 p following S59. PMID: 15055582.
    Citations: 38     Fields:    Translation:Animals
  34. Degterev A, Boyce M, Yuan J. A decade of caspases. Oncogene. 2003 Nov 24; 22(53):8543-67. PMID: 14634618.
    Citations: 217     Fields:    Translation:HumansAnimalsCells
  35. Yuan J, Lipinski M, Degterev A. Diversity in the mechanisms of neuronal cell death. Neuron. 2003 Oct 09; 40(2):401-13. PMID: 14556717.
    Citations: 121     Fields:    Translation:HumansAnimalsCells
  36. Welch K, Yuan J. Alpha-synuclein oligomerization: a role for lipids? Trends Neurosci. 2003 Oct; 26(10):517-9. PMID: 14522142.
    Citations: 11     Fields:    Translation:HumansAnimals
  37. Gozani O, Karuman P, Jones DR, Ivanov D, Cha J, Lugovskoy AA, Baird CL, Zhu H, Field SJ, Lessnick SL, Villasenor J, Mehrotra B, Chen J, Rao VR, Brugge JS, Ferguson CG, Payrastre B, Myszka DG, Cantley LC, Wagner G, Divecha N, Prestwich GD, Yuan J. The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell. 2003 Jul 11; 114(1):99-111. PMID: 12859901.
    Citations: 148     Fields:    Translation:HumansCells
  38. Zong WX, Li C, Hatzivassiliou G, Lindsten T, Yu QC, Yuan J, Thompson CB. Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis. J Cell Biol. 2003 Jul 07; 162(1):59-69. PMID: 12847083.
    Citations: 141     Fields:    Translation:AnimalsCells
  39. Kang SJ, Sanchez I, Jing N, Yuan J. Dissociation between neurodegeneration and caspase-11-mediated activation of caspase-1 and caspase-3 in a mouse model of amyotrophic lateral sclerosis. J Neurosci. 2003 Jul 02; 23(13):5455-60. PMID: 12843244.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  40. Sánchez I, Mahlke C, Yuan J. Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders. Nature. 2003 Jan 23; 421(6921):373-9. PMID: 12540902.
    Citations: 121     Fields:    Translation:HumansAnimalsCells
  41. Takai Y, Canning J, Perez GI, Pru JK, Schlezinger JJ, Sherr DH, Kolesnick RN, Yuan J, Flavell RA, Korsmeyer SJ, Tilly JL. Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo. Endocrinology. 2003 Jan; 144(1):69-74. PMID: 12488331.
    Citations: 16     Fields:    Translation:AnimalsCells
  42. Le DA, Wu Y, Huang Z, Matsushita K, Plesnila N, Augustinack JC, Hyman BT, Yuan J, Kuida K, Flavell RA, Moskowitz MA. Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation. Proc Natl Acad Sci U S A. 2002 Nov 12; 99(23):15188-93. PMID: 12415117.
    Citations: 60     Fields:    Translation:AnimalsCells
  43. Yoo LI, Chung DC, Yuan J. LKB1--a master tumour suppressor of the small intestine and beyond. Nat Rev Cancer. 2002 Jul; 2(7):529-35. PMID: 12094239.
    Citations: 33     Fields:    Translation:HumansAnimals
  44. Welch K, Yuan J. Releasing the nerve cell killers. Nat Med. 2002 Jun; 8(6):564-5. PMID: 12042803.
    Citations:    Fields:    Translation:HumansCells
  45. Gozani O, Boyce M, Yoo L, Karuman P, Yuan J. Life and death in paradise. Nat Cell Biol. 2002 Jun; 4(6):E159-62. PMID: 12042835.
    Citations:    Fields:    Translation:HumansAnimals
  46. Garden GA, Budd SL, Tsai E, Hanson L, Kaul M, D'Emilia DM, Friedlander RM, Yuan J, Masliah E, Lipton SA. Caspase cascades in human immunodeficiency virus-associated neurodegeneration. J Neurosci. 2002 May 15; 22(10):4015-24. PMID: 12019321.
    Citations: 90     Fields:    Translation:HumansAnimalsCells
  47. Qiu J, Whalen MJ, Lowenstein P, Fiskum G, Fahy B, Darwish R, Aarabi B, Yuan J, Moskowitz MA. Upregulation of the Fas receptor death-inducing signaling complex after traumatic brain injury in mice and humans. J Neurosci. 2002 May 01; 22(9):3504-11. PMID: 11978827.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  48. Lugovskoy AA, Degterev AI, Fahmy AF, Zhou P, Gross JD, Yuan J, Wagner G. A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors. J Am Chem Soc. 2002 Feb 20; 124(7):1234-40. PMID: 11841292.
    Citations: 15     Fields:    Translation:Cells
  49. Yuan J, Yankner BA. Apoptosis in the nervous system. Nature. 2000 Oct 12; 407(6805):802-9. PMID: 11048732.
    Citations: 389     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.