Harvard Catalyst Profiles

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Dorene May Rentz, Psy.D.

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Biography
1990
Magnuson Award
1993
Outstanding Alumni Award
2015
Laird Cermak Award for Memory Research

Overview
I am a practicing clinical neuropsychologist with dual appointments in the Departments of Neurology at Brigham and Women’s Hospital (BWH) and Massachusetts General Hospital (MGH). I am also the Co-Director of the Center for Alzheimer Research and Treatment (CART) at BWH, the Clinical Core Lead of the Harvard Aging Brain Study and the Director of the Neuropsychology as well as the Outreach, Recruitment and Engagement Core of the Massachusetts Alzheimer’s Disease Research Center at MGH. I have published over 100 peer-reviewed manuscripts in the area of normal aging and the early detection of cognitive decline in normal older adults who have biomarker evidence of preclinical Alzheimer’s Disease (AD).
I have been involved in the clinical assessment of patients and the supervision of clinical fellows in the Division of Cognitive and Behavioral Neurology at BWH for over 24 years. My specialty is in geriatric neuropsychology and the evaluation of high functioning elders. As a result, physicians have referred patients to me from all over the world.
Over the course of my career, I have had the wonderful opportunity to collaborate with colleagues such as Reisa Sperling MD, Keith Johnson MD and Kirk Daffner MD. They recognized my unique expertise that allowed me to make several distinct contributions to the fields of normal aging and AD. These contributions have had clinical relevance as well as shaped cognitive outcome measures in current AD prevention trials.
The first major contribution was furthering the understanding of cognitive reserve and the development of an IQ-Adjusted Method (Rentz et al 2004; 2007) for assessing cognition in patients with a high ability level. This method allows for the detection of early cognitive impairments that would otherwise go undetected using standard neuropsychological normative data, thus obscuring early diagnosis and treatment. Understanding the influence of cognitive reserve in preclinical AD (Rentz et al, 2010; 2017) has also had important implications for decisions regarding treatment effects in AD Prevention Trials.
The second contribution has been the development of sensitive cognitive tests (Face Name Associative Memory Exam, FNAME) and cognitive composites (Primary Alzheimer Cognitive Composite, PACC) as outcome measures for AD Prevention Trials. Tackling how to measure cognitive change in otherwise, cognitively normal older adults has been a major conundrum in the AD field. I have had the privilege of guiding the discussion about clinically sensitive cognitive tests and the value of combining these assessments within a clinical composite for the first ever Prevention Trial in AD. Over the past few years, with the help of talented junior faculty, we have determined that these cognitive composites are sensitive to decline in biomarker positive individuals (Mormino, E et al 2015; 2016; 2017 and Papp KV et al 2014; 2015; 2016; 2017). I have also had the privilege of exploring Subjective Cognitive Decline (SCD) as a patient-oriented outcome measure (Amariglio RE et al 2015; 2016; 2017); have acted as a leader in an International Working Group and have been an invited speaker on this subject at international conferences.
The third major contribution has been the use of computerized technology to administer cognitive tests for use in clinical trials and exploring the feasibility of performing these tests in the home environment when individuals cannot come to the clinic (Rentz et al 2016; 2017). I am currently working on the development of digital pen technology for detecting deficits in cognitive processing and decision-making that may be sensitive to early cognitive decline in neurodegenerative diseases. I have begun to partner with PCP and geriatric practices, with the help of two BWH behavioral neurologists and the Alzheimer’s Association, to develop a lecture series and to determine the usefulness of digital technology for conducting easy to administer cognitive tests in the PCP environment for dementia assessment.
In the past 2 years, I have had the privilege of developing a Community Service Outreach Initiative that provides education about Alzheimer’s disease and clinical trials in underserved Black and Hispanic communities in the Boston area. We have partnered with the NAACP Health Committee, Religious Leaders and State Representatives and are making efforts to reduce disparities in health care and increase opportunities for clinical trial participation.
Finally, and most importantly, I have had the privilege of mentoring and training the next generation of neuropsychologists for both clinical practice and clinical research. Several of these trainees have gone on to join the faculty at Harvard (Pam Friedman PsyD, Meghan Searl PhD, Kim Wilmett PhD), and two have received NIA K23 and Alzheimer’s Association awards as well as promotions to Assistant Professor (Rebecca Amariglio, PhD and Kathryn Papp, PhD). One research trainee (Elizabeth Mormino, PhD) has been asked to join the faculty of Stanford University and to head their research efforts in normal aging and preclinical Alzheimer’s disease. The privilege of mentoring these remarkable women and observing their growing reputation in the national and international arena will always be my most treasured legacy.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. P01AG036694 (SPERLING, REISA A.) Jul 15, 2010 - Mar 31, 2025
    NIH
    Impact of Amyloid and Tau on the Aging Brain: The Harvard Aging Brain Study
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Farrell ME, Papp KV, Buckley RF, Jacobs HIL, Schultz AP, Properzi MJ, Vannini P, Hanseeuw BJ, Rentz DM, Johnson KA, Sperling RA. Association of Emerging ß-Amyloid and Tau Pathology With Early Cognitive Changes in Clinically Normal Older Adults. Neurology. 2022 Apr 12; 98(15):e1512-e1524. PMID: 35338074.
    Citations:    Fields:    
  2. Prokopiou PC, Engels-Domínguez N, Papp KV, Scott MR, Schultz AP, Schneider C, Farrell ME, Buckley RF, Quiroz YT, El Fakhri G, Rentz DM, Sperling RA, Johnson KA, Jacobs HIL. Lower novelty-related locus coeruleus function is associated with Aß-related cognitive decline in clinically healthy individuals. Nat Commun. 2022 Mar 23; 13(1):1571. PMID: 35322012.
    Citations:    Fields:    
  3. Alegret M, Sotolongo-Grau O, de Antonio EE, Pérez-Cordón A, Orellana A, Espinosa A, Gil S, Jiménez D, Ortega G, Sanabria A, Roberto N, Hernández I, Rosende-Roca M, Tartari JP, Alarcon-Martin E, de Rojas I, Montrreal L, Morató X, Cano A, Rentz DM, Tárraga L, Ruiz A, Valero S, Marquié M, Boada M. Automatized FACEmemory® scoring is related to Alzheimer's disease phenotype and biomarkers in early-onset mild cognitive impairment: the BIOFACE cohort. Alzheimers Res Ther. 2022 Mar 18; 14(1):43. PMID: 35303916.
    Citations:    Fields:    
  4. Willey B, Mimmack K, Gagliardi G, Dossett ML, Wang S, Udeogu OJ, Donovan NJ, Gatchel JR, Quiroz YT, Amariglio R, Liu CH, Hyun S, ElTohamy A, Rentz D, Sperling RA, Marshall GA, Vannini P. Racial and socioeconomic status differences in stress, posttraumatic growth, and mental health in an older adult cohort during the COVID-19 pandemic. EClinicalMedicine. 2022 Mar; 45:101343. PMID: 35291556.
    Citations:    
  5. Quiroz YT, Solis M, Aranda MP, Arbaje AI, Arroyo-Miranda M, Cabrera LY, Carrasquillo MM, Corrada MM, Crivelli L, Diminich ED, Dorsman KA, Gonzales M, González HM, Gonzalez-Seda AL, Grinberg LT, Guerrero LR, Hill CV, Jimenez-Velazquez IZ, Guerra JJL, Lopera F, Maestre G, Medina LD, O'Bryant S, Peñaloza C, Pinzon MM, Mavarez RVP, Pluim CF, Raman R, Rascovsky K, Rentz DM, Reyes Y, Rosselli M, Tansey MG, Vila-Castelar C, Zuelsdorff M, Carrillo M, Sexton C. Addressing the disparities in dementia risk, early detection and care in Latino populations: Highlights from the second Latinos & Alzheimer's Symposium. Alzheimers Dement. 2022 Feb 24. PMID: 35199931.
    Citations:    Fields:    
  6. Grober E, Lipton RB, Sperling RA, Papp KV, Johnson KA, Rentz DM, Veroff AE, Aisen PS, Ezzati A. Associations of Stages of Objective Memory Impairment With Amyloid PET and Structural MRI: The A4 Study. Neurology. 2022 Mar 29; 98(13):e1327-e1336. PMID: 35197359.
    Citations:    Fields:    
  7. Munro CE, Buckley R, Vannini P, DeMuro C, Sperling R, Rentz DM, Johnson K, Gatchel JR, Amariglio R. Longitudinal Trajectories of Participant- and Study Partner-Rated Cognitive Decline, in Relation to Alzheimer's Disease Biomarkers and Mood Symptoms. Front Aging Neurosci. 2021; 13:806432. PMID: 35173601.
    Citations:    
  8. Jutten RJ, Rentz DM, Fu JF, Mayblyum DV, Amariglio RE, Buckley RF, Properzi MJ, Maruff P, Stark CE, Yassa MA, Johnson KA, Sperling RA, Papp KV. Monthly At-Home Computerized Cognitive Testing to Detect Diminished Practice Effects in Preclinical Alzheimer's Disease. Front Aging Neurosci. 2021; 13:800126. PMID: 35095476.
    Citations:    
  9. Grober E, Papp KV, Rentz DM, Sperling RA, Johnson KA, Amariglio RE, Schultz A, Lipton RB, Ezzati A. Neuroimaging correlates of Stages of Objective Memory Impairment (SOMI) system. Alzheimers Dement (Amst). 2021; 13(1):e12224. PMID: 35005192.
    Citations: 1     
  10. Weintraub S, Karpouzian-Rogers T, Peipert JD, Nowinski C, Slotkin J, Wortman K, Ho E, Rogalski E, Carlsson C, Giordani B, Goldstein F, Lucas J, Manly JJ, Rentz D, Salmon D, Snitz B, Dodge HH, Riley M, Eldes F, Ustsinovich V, Gershon R. ARMADA: Assessing reliable measurement in Alzheimer's disease and cognitive aging project methods. Alzheimers Dement. 2021 Nov 17. PMID: 34786833.
    Citations:    Fields:    
  11. Papp KV, Samaroo A, Chou HC, Buckley R, Schneider OR, Hsieh S, Soberanes D, Quiroz Y, Properzi M, Schultz A, García-Magariño I, Marshall GA, Burke JG, Kumar R, Snyder N, Johnson K, Rentz DM, Sperling RA, Amariglio RE. Unsupervised mobile cognitive testing for use in preclinical Alzheimer's disease. Alzheimers Dement (Amst). 2021; 13(1):e12243. PMID: 34621977.
    Citations:    
  12. Jacobs HIL, Becker JA, Kwong K, Engels-Domínguez N, Prokopiou PC, Papp KV, Properzi M, Hampton OL, d'Oleire Uquillas F, Sanchez JS, Rentz DM, El Fakhri G, Normandin MD, Price JC, Bennett DA, Sperling RA, Johnson KA. In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer's disease pathology and cognitive decline. Sci Transl Med. 2021 Sep 22; 13(612):eabj2511. PMID: 34550726.
    Citations: 4     Fields:    Translation:Humans
  13. Sevinc G, Rusche J, Wong B, Datta T, Kaufman R, Gutz SE, Schneider M, Todorova N, Gaser C, Thomalla G, Rentz D, Dickerson BD, Lazar SW. Mindfulness Training Improves Cognition and Strengthens Intrinsic Connectivity Between the Hippocampus and Posteromedial Cortex in Healthy Older Adults. Front Aging Neurosci. 2021; 13:702796. PMID: 34512305.
    Citations: 1     
  14. Salinas J, O'Donnell A, Kojis DJ, Pase MP, DeCarli C, Rentz DM, Berkman LF, Beiser A, Seshadri S. Association of Social Support With Brain Volume and Cognition. JAMA Netw Open. 2021 08 02; 4(8):e2121122. PMID: 34398201.
    Citations: 2     Fields:    Translation:Humans
  15. Raman R, Quiroz YT, Langford O, Choi J, Ritchie M, Baumgartner M, Rentz D, Aggarwal NT, Aisen P, Sperling R, Grill JD. Disparities by Race and Ethnicity Among Adults Recruited for a Preclinical Alzheimer Disease Trial. JAMA Netw Open. 2021 07 01; 4(7):e2114364. PMID: 34228129.
    Citations: 3     Fields:    Translation:Humans
  16. Rentz DM, Wessels AM, Annapragada AV, Berger AK, Edgar CJ, Gold M, Miller DS, Randolph C, Ryan JM, Wunderlich G, Zoschg MC, Trépel D, Knopman DS, Staffaroni AM, Bain LJ, Carrillo MC, Weber CJ. Building clinically relevant outcomes across the Alzheimer's disease spectrum. Alzheimers Dement (N Y). 2021; 7(1):e12181. PMID: 34195350.
    Citations:    
  17. Yang HS, Zhang C, Carlyle BC, Zhen SY, Trombetta BA, Schultz AP, Pruzin JJ, Fitzpatrick CD, Yau WW, Kirn DR, Rentz DM, Arnold SE, Johnson KA, Sperling RA, Chhatwal JP, Tanzi RE. Plasma IL-12/IFN-? axis predicts cognitive trajectories in cognitively unimpaired older adults. Alzheimers Dement. 2022 Apr; 18(4):645-653. PMID: 34160128.
    Citations: 4     Fields:    
  18. Mayblyum DV, Becker JA, Jacobs HIL, Buckley RF, Schultz AP, Sepulcre J, Sanchez JS, Rubinstein ZB, Katz SR, Moody KA, Vannini P, Papp KV, Rentz DM, Price JC, Sperling RA, Johnson KA, Hanseeuw BJ. Comparing PET and MRI Biomarkers Predicting Cognitive Decline in Preclinical Alzheimer Disease. Neurology. 2021 May 05. PMID: 33952655.
    Citations: 3     Fields:    
  19. Babulal GM, Torres VL, Acosta D, Agüero C, Aguilar-Navarro S, Amariglio R, Ussui JA, Baena A, Bocanegra Y, Brucki SMD, Bustin J, Cabrera DM, Custodio N, Diaz MM, Peñailillo LD, Franco I, Gatchel JR, Garza-Naveda AP, González Lara M, Gutiérrez-Gutiérrez L, Guzmán-Vélez E, Hanseeuw BJ, Jimenez-Velazquez IZ, Rodríguez TL, Llibre-Guerra J, Marquine MJ, Martinez J, Medina LD, Miranda-Castillo C, Morlett Paredes A, Munera D, Nuñez-Herrera A, de Oliveira MO, Palmer-Cancel SJ, Pardilla-Delgado E, Perales-Puchalt J, Pluim C, Ramirez-Gomez L, Rentz DM, Rivera-Fernández C, Rosselli M, Serrano CM, Suing-Ortega MJ, Slachevsky A, Soto-Añari M, Sperling RA, Torrente F, Thumala D, Vannini P, Vila-Castelar C, Yañez-Escalante T, Quiroz YT. The impact of COVID-19 on the well-being and cognition of older adults living in the United States and Latin America. EClinicalMedicine. 2021 May; 35:100848. PMID: 33997742.
    Citations: 2     
  20. Rentz DM, Papp KV, Mayblyum DV, Sanchez JS, Klein H, Souillard-Mandar W, Sperling RA, Johnson KA. Association of Digital Clock Drawing With PET Amyloid and Tau Pathology in Normal Older Adults. Neurology. 2021 04 06; 96(14):e1844-e1854. PMID: 33589537.
    Citations: 5     Fields:    Translation:Humans
  21. Sanchez JS, Becker JA, Jacobs HIL, Hanseeuw BJ, Jiang S, Schultz AP, Properzi MJ, Katz SR, Beiser A, Satizabal CL, O'Donnell A, DeCarli C, Killiany R, El Fakhri G, Normandin MD, Gómez-Isla T, Quiroz YT, Rentz DM, Sperling RA, Seshadri S, Augustinack J, Price JC, Johnson KA. The cortical origin and initial spread of medial temporal tauopathy in Alzheimer's disease assessed with positron emission tomography. Sci Transl Med. 2021 01 20; 13(577). PMID: 33472953.
    Citations: 16     Fields:    Translation:Humans
  22. Samaroo A, Amariglio RE, Burnham S, Sparks P, Properzi M, Schultz AP, Buckley R, Johnson KA, Sperling RA, Rentz DM, Papp KV. Diminished Learning Over Repeated Exposures (LORE) in preclinical Alzheimer's disease. Alzheimers Dement (Amst). 2020; 12(1):e12132. PMID: 33426266.
    Citations: 5     
  23. Amariglio RE, Sikkes SAM, Marshall GA, Buckley RF, Gatchel JR, Johnson KA, Rentz DM, Donohue MC, Raman R, Sun CK, Yaari R, Holdridge KC, Sims JR, Grill JD, Aisen PS, Sperling RA. Item-Level Investigation of Participant and Study Partner Report on the Cognitive Function Index from the A4 Study Screening Data. J Prev Alzheimers Dis. 2021; 8(3):257-262. PMID: 34101781.
    Citations: 2     Fields:    Translation:Humans
  24. Papp KV, Rentz DM, Maruff P, Sun CK, Raman R, Donohue MC, Schembri A, Stark C, Yassa MA, Wessels AM, Yaari R, Holdridge KC, Aisen PS, Sperling RA. The Computerized Cognitive Composite (C3) in an Alzheimer's Disease Secondary Prevention Trial. J Prev Alzheimers Dis. 2021; 8(1):59-67. PMID: 33336226.
    Citations: 12     Fields:    Translation:HumansPHPublic Health
  25. Farrell ME, Jiang S, Schultz AP, Properzi MJ, Price JC, Becker JA, Jacobs HIL, Hanseeuw BJ, Rentz DM, Villemagne VL, Papp KV, Mormino EC, Betensky RA, Johnson KA, Sperling RA, Buckley RF. Defining the Lowest Threshold for Amyloid-PET to Predict Future Cognitive Decline and Amyloid Accumulation. Neurology. 2021 01 26; 96(4):e619-e631. PMID: 33199430.
    Citations: 6     Fields:    Translation:Humans
  26. Marshall GA, Sikkes SAM, Amariglio RE, Gatchel JR, Rentz DM, Johnson KA, Langford O, Sun CK, Donohue MC, Raman R, Aisen PS, Sperling RA, Galasko DR. Instrumental activities of daily living, amyloid, and cognition in cognitively normal older adults screening for the A4 Study. Alzheimers Dement (Amst). 2020; 12(1):e12118. PMID: 33163609.
    Citations: 1     
  27. Dubbelman MA, Jutten RJ, Tomaszewski Farias SE, Amariglio RE, Buckley RF, Visser PJ, Rentz DM, Johnson KA, Properzi MJ, Schultz A, Donovan N, Gatchell JR, Teunissen CE, Van Berckel BNM, Van der Flier WM, Sperling RA, Papp KV, Scheltens P, Marshall GA, Sikkes SAM. Decline in cognitively complex everyday activities accelerates along the Alzheimer's disease continuum. Alzheimers Res Ther. 2020 10 29; 12(1):138. PMID: 33121534.
    Citations: 1     Fields:    Translation:Humans
  28. Jutten RJ, Sikkes SAM, Amariglio RE, Buckley RF, Properzi MJ, Marshall GA, Rentz DM, Johnson KA, Teunissen CE, Van Berckel BNM, Van der Flier WM, Scheltens P, Sperling RA, Papp KV. Identifying Sensitive Measures of Cognitive Decline at Different Clinical Stages of Alzheimer's Disease. J Int Neuropsychol Soc. 2021 05; 27(5):426-438. PMID: 33046162.
    Citations: 5     Fields:    Translation:Humans
  29. Hanseeuw BJ, Jonas V, Jackson J, Betensky RA, Rentz DM, Johnson KA, Sperling RA, Donovan NJ. Correction: Association of anxiety with subcortical amyloidosis in cognitively normal older adults. Mol Psychiatry. 2020 Oct; 25(10):2644. PMID: 30538309.
    Citations: 2     Fields:    
  30. Vila-Castelar C, Muñoz N, Papp KV, Amariglio RE, Baena A, Guzmán-Vélez E, Bocanegra Y, Sanchez JS, Reiman EM, Johnson KA, Sperling RA, Lopera F, Rentz DM, Quiroz YT. The Latin American Spanish version of the Face-Name Associative Memory Exam is sensitive to cognitive and pathological changes in preclinical autosomal dominant Alzheimer's disease. Alzheimers Res Ther. 2020 09 10; 12(1):104. PMID: 32912283.
    Citations: 1     Fields:    Translation:Humans
  31. Buckley RF, Scott MR, Jacobs HIL, Schultz AP, Properzi MJ, Amariglio RE, Hohman TJ, Mayblyum DV, Rubinstein ZB, Manning L, Hanseeuw BJ, Mormino EC, Rentz DM, Johnson KA, Sperling RA. Sex Mediates Relationships Between Regional Tau Pathology and Cognitive Decline. Ann Neurol. 2020 11; 88(5):921-932. PMID: 32799367.
    Citations: 4     Fields:    Translation:Humans
  32. Rabin JS, Neal TE, Nierle HE, Sikkes SAM, Buckley RF, Amariglio RE, Papp KV, Rentz DM, Schultz AP, Johnson KA, Sperling RA, Hedden T. Multiple markers contribute to risk of progression from normal to mild cognitive impairment. Neuroimage Clin. 2020; 28:102400. PMID: 32919366.
    Citations: 3     Fields:    Translation:Humans
  33. Norton DJ, Parra MA, Sperling RA, Baena A, Guzman-Velez E, Jin DS, Andrea N, Khang J, Schultz A, Rentz DM, Pardilla-Delgado E, Fuller J, Johnson K, Reiman EM, Lopera F, Quiroz YT. Visual short-term memory relates to tau and amyloid burdens in preclinical autosomal dominant Alzheimer's disease. Alzheimers Res Ther. 2020 08 21; 12(1):99. PMID: 32825838.
    Citations: 2     Fields:    Translation:Humans
  34. Guzmán-Vélez E, Martínez J, Papp K, Baena A, Vila-Castelar C, Artola A, Schultz AP, Bocanegra Y, Sanchez J, Rentz D, Tariot PN, Reiman EM, Sperling R, Johnson KA, Lopera F, Quiroz YT. Associative memory and in vivo brain pathology in asymptomatic presenilin-1 E280A carriers. Neurology. 2020 09 08; 95(10):e1312-e1321. PMID: 32611637.
    Citations: 2     Fields:    Translation:Humans
  35. Burnham SC, Laws SM, Budgeon CA, Doré V, Porter T, Bourgeat P, Buckley RF, Murray K, Ellis KA, Turlach BA, Salvado O, Ames D, Martins RN, Rentz D, Masters CL, Rowe CC, Villemagne VL. Impact of APOE-e4 carriage on the onset and rates of neocortical Aß-amyloid deposition. Neurobiol Aging. 2020 11; 95:46-55. PMID: 32750666.
    Citations: 7     Fields:    Translation:Humans
  36. Rentz DM, Papp KV. Commentary on Composite cognitive and functional measures for early stage Alzheimer's disease trials. Alzheimers Dement (Amst). 2020; 12(1):e12012. PMID: 33521233.
    Citations:    
  37. Rentz DM, Wessels AM, Bain LJ, Weber CJ, Carrillo MC. Clinical meaningfulness addressed at Alzheimer's Association Research Roundtable. Alzheimers Dement. 2020 05; 16(5):814. PMID: 32386282.
    Citations: 1     Fields:    Translation:Humans
  38. Jacobs HIL, Augustinack JC, Schultz AP, Hanseeuw BJ, Locascio J, Amariglio RE, Papp KV, Rentz DM, Sperling RA, Johnson KA. The presubiculum links incipient amyloid and tau pathology to memory function in older persons. Neurology. 2020 05 05; 94(18):e1916-e1928. PMID: 32273431.
    Citations: 6     Fields:    Translation:Humans
  39. Alegret M, Muñoz N, Roberto N, Rentz DM, Valero S, Gil S, Marquié M, Hernández I, Riveros C, Sanabria A, Perez-Cordon A, Espinosa A, Ortega G, Mauleón A, Abdelnour C, Rosende-Roca M, Papp KV, Orellana A, Benaque A, Tarraga L, Ruiz A, Boada M. A computerized version of the Short Form of the Face-Name Associative Memory Exam (FACEmemory®) for the early detection of Alzheimer's disease. Alzheimers Res Ther. 2020 03 16; 12(1):25. PMID: 32178724.
    Citations: 6     Fields:    Translation:Humans
  40. Rabin JS, Shirzadi Z, Swardfager W, MacIntosh BJ, Schultz A, Yang HS, Buckley RF, Gatchel JR, Kirn D, Pruzin JJ, Hedden T, Lipsman N, Rentz DM, Black SE, Johnson KA, Sperling RA, Chhatwal JP. Amyloid-beta burden predicts prospective decline in body mass index in clinically normal adults. Neurobiol Aging. 2020 09; 93:124-130. PMID: 32249013.
    Citations: 5     Fields:    Translation:Humans
  41. Biddle KD, Jacobs HIL, d'Oleire Uquillas F, Zide BS, Kirn DR, Properzi MR, Rentz DM, Johnson KA, Sperling RA, Donovan NJ. Associations of Widowhood and ß-Amyloid With Cognitive Decline in Cognitively Unimpaired Older Adults. JAMA Netw Open. 2020 02 05; 3(2):e200121. PMID: 32101313.
    Citations: 11     Fields:    Translation:Humans
  42. Jessen F, Amariglio RE, Buckley RF, van der Flier WM, Han Y, Molinuevo JL, Rabin L, Rentz DM, Rodriguez-Gomez O, Saykin AJ, Sikkes SAM, Smart CM, Wolfsgruber S, Wagner M. The characterisation of subjective cognitive decline. Lancet Neurol. 2020 03; 19(3):271-278. PMID: 31958406.
    Citations: 117     Fields:    Translation:Humans
  43. Papp KV, Buckley R, Mormino E, Maruff P, Villemagne VL, Masters CL, Johnson KA, Rentz DM, Sperling RA, Amariglio RE. Clinical meaningfulness of subtle cognitive decline on longitudinal testing in preclinical AD. Alzheimers Dement. 2020 03; 16(3):552-560. PMID: 31759879.
    Citations: 25     Fields:    Translation:Humans
  44. Robinson RL, Rentz DM, Andrews JS, Zagar A, Kim Y, Bruemmer V, Schwartz RL, Ye W, Fillit HM. Costs of Early Stage Alzheimer's Disease in the United States: Cross-Sectional Analysis of a Prospective Cohort Study (GERAS-US)1. J Alzheimers Dis. 2020; 75(2):437-450. PMID: 32250304.
    Citations: 6     Fields:    Translation:Humans
  45. Amariglio RE, Buckley RF, Rabin JS, Papp KV, Quiroz YT, Mormino EC, Sparks KP, Johnson KA, Rentz DM, Sperling RA. Examining Cognitive Decline Across Black and White Participants in the Harvard Aging Brain Study. J Alzheimers Dis. 2020; 75(4):1437-1446. PMID: 32417775.
    Citations: 7     Fields:    Translation:Humans
  46. Gatchel JR, Lopera F, Norton DJ, Baena A, Guzman-Velez E, Sanchez JS, d'Oleire Uquillas F, Schultz A, Vannini P, Artola A, Amariglio RE, Rentz DM, Tariot PN, Reiman EM, Johnson KA, Sperling RA, Marshall GA, Quiroz YT. Association of subjective cognitive decline with markers of brain pathology in preclinical autosomal dominant Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2020 03; 91(3):330-332. PMID: 31874859.
    Citations: 4     Fields:    Translation:Humans
  47. Konishi K, Cherkerzian S, Aroner S, Jacobs EG, Rentz DM, Remington A, Aizley H, Hornig M, Klibanski A, Goldstein JM. Impact of BDNF and sex on maintaining intact memory function in early midlife. Neurobiol Aging. 2020 04; 88:137-149. PMID: 31948671.
    Citations: 3     Fields:    Translation:Humans
  48. Vila-Castelar C, Papp KV, Amariglio RE, Torres VL, Baena A, Gomez D, Rendon J, Samaroo A, Lopera F, Rentz DM, Quiroz YT. Validation of the Latin American Spanish version of the face-name associative memory exam in a Colombian Sample. Clin Neuropsychol. 2020 12; 34(sup1):1-12. PMID: 31851865.
    Citations: 6     Fields:    Translation:Humans
  49. Vannini P, d'Oleire Uquillas F, Jacobs HIL, Sepulcre J, Gatchel J, Amariglio RE, Hanseeuw B, Papp KV, Hedden T, Rentz DM, Pascual-Leone A, Johnson KA, Sperling RA. Decreased meta-memory is associated with early tauopathy in cognitively unimpaired older adults. Neuroimage Clin. 2019; 24:102097. PMID: 31795044.
    Citations: 1     Fields:    Translation:Humans
  50. Rabin JS, Klein H, Kirn DR, Schultz AP, Yang HS, Hampton O, Jiang S, Buckley RF, Viswanathan A, Hedden T, Pruzin J, Yau WW, Guzmán-Vélez E, Quiroz YT, Properzi M, Marshall GA, Rentz DM, Johnson KA, Sperling RA, Chhatwal JP. Associations of Physical Activity and ß-Amyloid With Longitudinal Cognition and Neurodegeneration in Clinically Normal Older Adults. JAMA Neurol. 2019 Oct 01; 76(10):1203-1210. PMID: 31312836.
    Citations: 20     Fields:    
  51. Buckley RF, Sikkes S, Villemagne VL, Mormino EC, Rabin JS, Burnham S, Papp KV, Doré V, Masters CL, Properzi MJ, Schultz AP, Johnson KA, Rentz DM, Sperling RA, Amariglio RE. Using subjective cognitive decline to identify high global amyloid in community-based samples: A cross-cohort study. Alzheimers Dement (Amst). 2019 Dec; 11:670-678. PMID: 31673597.
    Citations: 4     
  52. Bettcher BM, Gross AL, Gavett BE, Widaman KF, Fletcher E, Dowling NM, Buckley RF, Arenaza-Urquijo EM, Zahodne LB, Hohman TJ, Vonk JMJ, Rentz DM, Mungas D. Dynamic change of cognitive reserve: associations with changes in brain, cognition, and diagnosis. Neurobiol Aging. 2019 11; 83:95-104. PMID: 31585371.
    Citations: 8     Fields:    Translation:Humans
  53. Gatchel JR, Rabin JS, Buckley RF, Locascio JJ, Quiroz YT, Yang HS, Vannini P, Amariglio RE, Rentz DM, Properzi M, Donovan NJ, Blacker D, Johnson KA, Sperling RA, Marshall GA. Longitudinal Association of Depression Symptoms With Cognition and Cortical Amyloid Among Community-Dwelling Older Adults. JAMA Netw Open. 2019 08 02; 2(8):e198964. PMID: 31397865.
    Citations: 17     Fields:    Translation:Humans
  54. Hanseeuw BJ, Betensky RA, Jacobs HIL, Schultz AP, Sepulcre J, Becker JA, Cosio DMO, Farrell M, Quiroz YT, Mormino EC, Buckley RF, Papp KV, Amariglio RA, Dewachter I, Ivanoiu A, Huijbers W, Hedden T, Marshall GA, Chhatwal JP, Rentz DM, Sperling RA, Johnson K. Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease: A Longitudinal Study. JAMA Neurol. 2019 Aug 01; 76(8):915-924. PMID: 31157827.
    Citations: 152     Fields:    
  55. Chhatwal JP, Schultz AP, Hedden T, Boot BP, Wigman S, Rentz D, Johnson KA, Sperling RA. Anticholinergic Amnesia is Mediated by Alterations in Human Network Connectivity Architecture. Cereb Cortex. 2019 07 22; 29(8):3445-3456. PMID: 30192928.
    Citations: 2     Fields:    Translation:Humans
  56. Bott NT, Madero EN, Glenn JM, Lange AR, Anderson JJ, Newton DO, Brennan AH, Buffalo EA, Rentz DM, Zola SM. Device-Embedded Cameras for Eye Tracking-Based Cognitive Assessment: Implications for Teleneuropsychology. Telemed J E Health. 2020 04; 26(4):477-481. PMID: 31161968.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  57. Biddle KD, d'Oleire Uquillas F, Jacobs HIL, Zide B, Kirn DR, Rentz DM, Johnson KA, Sperling RA, Donovan NJ. Social Engagement and Amyloid-ß-Related Cognitive Decline in Cognitively Normal Older Adults. Am J Geriatr Psychiatry. 2019 11; 27(11):1247-1256. PMID: 31248770.
    Citations: 11     Fields:    Translation:Humans
  58. Buckley RF, Mormino EC, Rabin JS, Hohman TJ, Landau S, Hanseeuw BJ, Jacobs HIL, Papp KV, Amariglio RE, Properzi MJ, Schultz AP, Kirn D, Scott MR, Hedden T, Farrell M, Price J, Chhatwal J, Rentz DM, Villemagne VL, Johnson KA, Sperling RA. Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured by Positron Emission Tomography in Clinically Normal Older Adults. JAMA Neurol. 2019 05 01; 76(5):542-551. PMID: 30715078.
    Citations: 74     Fields:    Translation:Humans
  59. Buckley RF, Mormino EC, Chhatwal J, Schultz AP, Rabin JS, Rentz DM, Acar D, Properzi MJ, Dumurgier J, Jacobs H, Gomez-Isla T, Johnson KA, Sperling RA, Hanseeuw BJ. Associations between baseline amyloid, sex, and APOE on subsequent tau accumulation in cerebrospinal fluid. Neurobiol Aging. 2019 06; 78:178-185. PMID: 30947113.
    Citations: 19     Fields:    Translation:Humans
  60. Halawa OA, Gatchel JR, Amariglio RE, Rentz DM, Sperling RA, Johnson KA, Marshall GA. Inferior and medial temporal tau and cortical amyloid are associated with daily functional impairment in Alzheimer's disease. Alzheimers Res Ther. 2019 01 31; 11(1):14. PMID: 30704519.
    Citations: 9     Fields:    Translation:Humans
  61. Sperling RA, Mormino EC, Schultz AP, Betensky RA, Papp KV, Amariglio RE, Hanseeuw BJ, Buckley R, Chhatwal J, Hedden T, Marshall GA, Quiroz YT, Donovan NJ, Jackson J, Gatchel JR, Rabin JS, Jacobs H, Yang HS, Properzi M, Kirn DR, Rentz DM, Johnson KA. The impact of amyloid-beta and tau on prospective cognitive decline in older individuals. Ann Neurol. 2019 02; 85(2):181-193. PMID: 30549303.
    Citations: 65     Fields:    Translation:Humans
  62. Marshall GA, Aghjayan SL, Dekhtyar M, Locascio JJ, Jethwani K, Amariglio RE, Czaja SJ, Loewenstein DA, Johnson KA, Sperling RA, Rentz DM. Measuring instrumental activities of daily living in non-demented elderly: a comparison of the new performance-based Harvard Automated Phone Task with other functional assessments. Alzheimers Res Ther. 2019 01 10; 11(1):4. PMID: 30630529.
    Citations: 1     Fields:    Translation:Humans
  63. Rabin JS, Yang HS, Schultz AP, Hanseeuw BJ, Hedden T, Viswanathan A, Gatchel JR, Marshall GA, Kilpatrick E, Klein H, Rao V, Buckley RF, Yau WW, Kirn DR, Rentz DM, Johnson KA, Sperling RA, Chhatwal JP. Vascular Risk and ß-Amyloid Are Synergistically Associated with Cortical Tau. Ann Neurol. 2019 02; 85(2):272-279. PMID: 30565287.
    Citations: 30     Fields:    Translation:Humans
  64. Marshall GA, Gatchel JR, Donovan NJ, Muniz MC, Schultz AP, Becker JA, Chhatwal JP, Hanseeuw BJ, Papp KV, Amariglio RE, Rentz DM, Sperling RA, Johnson KA. Regional Tau Correlates of Instrumental Activities of Daily Living and Apathy in Mild Cognitive Impairment and Alzheimer's Disease Dementia. J Alzheimers Dis. 2019; 67(2):757-768. PMID: 30689584.
    Citations: 9     Fields:    Translation:Humans
  65. Yang HS, Chhatwal JP, Xu J, White CC, Hanseeuw B, Rabin JS, Papp KV, Buckley RF, Schultz AP, Properzi MJ, Gatchel JR, Amariglio RE, Donovan NJ, Mormino EC, Hedden T, Marshall GA, Rentz DM, Johnson KA, De Jager PL, Sperling RA. An UNC5C Allele Predicts Cognitive Decline and Hippocampal Atrophy in Clinically Normal Older Adults. J Alzheimers Dis. 2019; 68(3):1161-1170. PMID: 30883345.
    Citations: 1     Fields:    Translation:Humans
  66. Robinson RL, Rentz DM, Bruemmer V, Scott Andrews J, Zagar A, Kim Y, Schwartz RL, Ye W, Fillit HM. Observation of Patient and Caregiver Burden Associated with Early Alzheimer's Disease in the United States: Design and Baseline Findings of the GERAS-US Cohort Study1. J Alzheimers Dis. 2019; 72(1):279-292. PMID: 31561360.
    Citations: 3     Fields:    Translation:Humans
  67. d'Oleire Uquillas F, Jacobs HIL, Biddle KD, Properzi M, Hanseeuw B, Schultz AP, Rentz DM, Johnson KA, Sperling RA, Donovan NJ. Regional tau pathology and loneliness in cognitively normal older adults. Transl Psychiatry. 2018 12 18; 8(1):282. PMID: 30563962.
    Citations: 14     Fields:    Translation:Humans
  68. Amariglio RE, Buckley RF, Mormino EC, Marshall GA, Johnson KA, Rentz DM, Sperling RA. Amyloid-associated increases in longitudinal report of subjective cognitive complaints. Alzheimers Dement (N Y). 2018; 4:444-449. PMID: 30258973.
    Citations: 21     
  69. Rabin JS, Schultz AP, Hedden T, Viswanathan A, Marshall GA, Kilpatrick E, Klein H, Buckley RF, Yang HS, Properzi M, Rao V, Kirn DR, Papp KV, Rentz DM, Johnson KA, Sperling RA, Chhatwal JP. Interactive Associations of Vascular Risk and ß-Amyloid Burden With Cognitive Decline in Clinically Normal Elderly Individuals: Findings From the Harvard Aging Brain Study. JAMA Neurol. 2018 09 01; 75(9):1124-1131. PMID: 29799986.
    Citations: 59     Fields:    Translation:Humans
  70. Hanseeuw BJ, Jonas V, Jackson J, Betensky RA, Rentz DM, Johnson KA, Sperling RA, Donovan NJ. Association of anxiety with subcortical amyloidosis in cognitively normal older adults. Mol Psychiatry. 2020 10; 25(10):2599-2607. PMID: 30116029.
    Citations: 10     Fields:    Translation:Humans
  71. Bott N, Madero EN, Glenn J, Lange A, Anderson J, Newton D, Brennan A, Buffalo EA, Rentz D, Zola S. Device-Embedded Cameras for Eye Tracking-Based Cognitive Assessment: Validation With Paper-Pencil and Computerized Cognitive Composites. J Med Internet Res. 2018 07 24; 20(7):e11143. PMID: 30042093.
    Citations: 11     Fields:    Translation:Humans
  72. Buckley RF, Mormino EC, Amariglio RE, Properzi MJ, Rabin JS, Lim YY, Papp KV, Jacobs HIL, Burnham S, Hanseeuw BJ, Doré V, Dobson A, Masters CL, Waller M, Rowe CC, Maruff P, Donohue MC, Rentz DM, Kirn D, Hedden T, Chhatwal J, Schultz AP, Johnson KA, Villemagne VL, Sperling RA. Sex, amyloid, and APOE e4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well-characterized cohorts. Alzheimers Dement. 2018 09; 14(9):1193-1203. PMID: 29803541.
    Citations: 64     Fields:    Translation:Humans
  73. Hanseeuw BJ, Betensky RA, Mormino EC, Schultz AP, Sepulcre J, Becker JA, Jacobs HIL, Buckley RF, LaPoint MR, Vannini P, Donovan NJ, Chhatwal JP, Marshall GA, Papp KV, Amariglio RE, Rentz DM, Sperling RA, Johnson KA. PET staging of amyloidosis using striatum. Alzheimers Dement. 2018 10; 14(10):1281-1292. PMID: 29792874.
    Citations: 38     Fields:    Translation:Humans
  74. Munro CE, Donovan NJ, Amariglio RE, Papp KV, Marshall GA, Rentz DM, Pascual-Leone A, Sperling RA, Locascio JJ, Vannini P. The Impact of Awareness of and Concern About Memory Performance on the Prediction of Progression From Mild Cognitive Impairment to Alzheimer Disease Dementia. Am J Geriatr Psychiatry. 2018 08; 26(8):896-904. PMID: 29866588.
    Citations: 14     Fields:    Translation:Humans
  75. Sanabria A, Alegret M, Rodriguez-Gomez O, Valero S, Sotolongo-Grau O, Monté-Rubio G, Abdelnour C, Espinosa A, Ortega G, Perez-Cordon A, Gailhajanet A, Hernandez I, Rosende-Roca M, Vargas L, Mauleon A, Sanchez D, Martin E, Rentz DM, Lomeña F, Ruiz A, Tarraga L, Boada M. The Spanish version of Face-Name Associative Memory Exam (S-FNAME) performance is related to amyloid burden in Subjective Cognitive Decline. Sci Rep. 2018 02 28; 8(1):3828. PMID: 29491481.
    Citations: 15     Fields:    Translation:Humans
  76. Jacobs HIL, Hedden T, Schultz AP, Sepulcre J, Perea RD, Amariglio RE, Papp KV, Rentz DM, Sperling RA, Johnson KA. Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals. Nat Neurosci. 2018 03; 21(3):424-431. PMID: 29403032.
    Citations: 92     Fields:    Translation:Humans
  77. Donovan NJ, Locascio JJ, Marshall GA, Gatchel J, Hanseeuw BJ, Rentz DM, Johnson KA, Sperling RA. Longitudinal Association of Amyloid Beta and Anxious-Depressive Symptoms in Cognitively Normal Older Adults. Am J Psychiatry. 2018 06 01; 175(6):530-537. PMID: 29325447.
    Citations: 60     Fields:    Translation:Humans
  78. Harrison JE, Rentz DM, Brashear HR, Arrighi HM, Ropacki MT, Liu E. Psychometric Evaluation of the Neuropsychological Test Battery in Individuals with Normal Cognition, Mild Cognitive Impairment, or Mild to Moderate Alzheimer's Disease: Results from a Longitudinal Study. J Prev Alzheimers Dis. 2018; 5(4):236-244. PMID: 30298182.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  79. Guzmán-Vélez E, Jaimes S, Aguirre-Acevedo DC, Norton DJ, Papp KV, Amariglio R, Rentz D, Baena A, Henao E, Tirado V, Muñoz C, Giraldo M, Sperling RA, Lopera F, Quiroz YT. A Three-Factor Structure of Cognitive Functioning Among Unimpaired Carriers and Non-Carriers of Autosomal-Dominant Alzheimer's Disease. J Alzheimers Dis. 2018; 65(1):107-115. PMID: 30040714.
    Citations: 6     Fields:    Translation:Humans
  80. Buckley RF, Hanseeuw B, Schultz AP, Vannini P, Aghjayan SL, Properzi MJ, Jackson JD, Mormino EC, Rentz DM, Sperling RA, Johnson KA, Amariglio RE. Region-Specific Association of Subjective Cognitive Decline With Tauopathy Independent of Global ß-Amyloid Burden. JAMA Neurol. 2017 12 01; 74(12):1455-1463. PMID: 28973551.
    Citations: 54     Fields:    Translation:Humans
  81. Orlovsky I, Huijbers W, Hanseeuw BJ, Mormino EC, Hedden T, Buckley RF, LaPoint M, Rabin JS, Rentz DM, Johnson KA, Sperling RA, Papp KV. The relationship between recall of recently versus remotely encoded famous faces and amyloidosis in clinically normal older adults. Alzheimers Dement (Amst). 2018; 10:121-129. PMID: 29780861.
    Citations: 6     
  82. Papp KV, Rentz DM, Orlovsky I, Sperling RA, Mormino EC. Optimizing the preclinical Alzheimer's cognitive composite with semantic processing: The PACC5. Alzheimers Dement (N Y). 2017 Nov; 3(4):668-677. PMID: 29264389.
    Citations: 45     
  83. Jackson JD, Rentz DM, Aghjayan SL, Buckley RF, Meneide TF, Sperling RA, Amariglio RE. Subjective cognitive concerns are associated with objective memory performance in Caucasian but not African-American persons. Age Ageing. 2017 11 01; 46(6):988-993. PMID: 29088363.
    Citations: 18     Fields:    Translation:Humans
  84. Huijbers W, Papp KV, LaPoint M, Wigman SE, Dagley A, Hedden T, Rentz DM, Schultz AP, Sperling RA. Age-Related Increases in Tip-of-the-tongue are Distinct from Decreases in Remembering Names: A Functional MRI Study. Cereb Cortex. 2017 09 01; 27(9):4339-4349. PMID: 27578492.
    Citations: 5     Fields:    Translation:Humans
  85. Bott NT, Lange A, Rentz D, Buffalo E, Clopton P, Zola S. Web Camera Based Eye Tracking to Assess Visual Memory on a Visual Paired Comparison Task. Front Neurosci. 2017; 11:370. PMID: 28701915.
    Citations: 11     
  86. Buckley RF, Schultz AP, Hedden T, Papp KV, Hanseeuw BJ, Marshall G, Sepulcre J, Smith EE, Rentz DM, Johnson KA, Sperling RA, Chhatwal JP. Functional network integrity presages cognitive decline in preclinical Alzheimer disease. Neurology. 2017 Jul 04; 89(1):29-37. PMID: 28592457.
    Citations: 39     Fields:    Translation:Humans
  87. Vannini P, Hanseeuw B, Munro CE, Amariglio RE, Marshall GA, Rentz DM, Pascual-Leone A, Johnson KA, Sperling RA. Anosognosia for memory deficits in mild cognitive impairment: Insight into the neural mechanism using functional and molecular imaging. Neuroimage Clin. 2017; 15:408-414. PMID: 28616381.
    Citations: 25     Fields:    Translation:Humans
  88. Dekhtyar M, Papp KV, Buckley R, Jacobs HIL, Schultz AP, Johnson KA, Sperling RA, Rentz DM. Neuroimaging markers associated with maintenance of optimal memory performance in late-life. Neuropsychologia. 2017 06; 100:164-170.