Harvard Catalyst Profiles

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Dorene May Rentz, Psy.D.

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Biography
1990
Magnuson Award
1993
Outstanding Alumni Award
2015
Laird Cermak Award for Memory Research

Overview
I am a practicing clinical neuropsychologist with dual appointments in the Departments of Neurology at Brigham and Women’s Hospital (BWH) and Massachusetts General Hospital (MGH). I am also the Co-Director of the Center for Alzheimer Research and Treatment (CART) at BWH, the Clinical Core Lead of the Harvard Aging Brain Study and the Director of the Neuropsychology as well as the Outreach, Recruitment and Engagement Core of the Massachusetts Alzheimer’s Disease Research Center at MGH. I have published over 100 peer-reviewed manuscripts in the area of normal aging and the early detection of cognitive decline in normal older adults who have biomarker evidence of preclinical Alzheimer’s Disease (AD).
I have been involved in the clinical assessment of patients and the supervision of clinical fellows in the Division of Cognitive and Behavioral Neurology at BWH for over 24 years. My specialty is in geriatric neuropsychology and the evaluation of high functioning elders. As a result, physicians have referred patients to me from all over the world.
Over the course of my career, I have had the wonderful opportunity to collaborate with colleagues such as Reisa Sperling MD, Keith Johnson MD and Kirk Daffner MD. They recognized my unique expertise that allowed me to make several distinct contributions to the fields of normal aging and AD. These contributions have had clinical relevance as well as shaped cognitive outcome measures in current AD prevention trials.
The first major contribution was furthering the understanding of cognitive reserve and the development of an IQ-Adjusted Method (Rentz et al 2004; 2007) for assessing cognition in patients with a high ability level. This method allows for the detection of early cognitive impairments that would otherwise go undetected using standard neuropsychological normative data, thus obscuring early diagnosis and treatment. Understanding the influence of cognitive reserve in preclinical AD (Rentz et al, 2010; 2017) has also had important implications for decisions regarding treatment effects in AD Prevention Trials.
The second contribution has been the development of sensitive cognitive tests (Face Name Associative Memory Exam, FNAME) and cognitive composites (Primary Alzheimer Cognitive Composite, PACC) as outcome measures for AD Prevention Trials. Tackling how to measure cognitive change in otherwise, cognitively normal older adults has been a major conundrum in the AD field. I have had the privilege of guiding the discussion about clinically sensitive cognitive tests and the value of combining these assessments within a clinical composite for the first ever Prevention Trial in AD. Over the past few years, with the help of talented junior faculty, we have determined that these cognitive composites are sensitive to decline in biomarker positive individuals (Mormino, E et al 2015; 2016; 2017 and Papp KV et al 2014; 2015; 2016; 2017). I have also had the privilege of exploring Subjective Cognitive Decline (SCD) as a patient-oriented outcome measure (Amariglio RE et al 2015; 2016; 2017); have acted as a leader in an International Working Group and have been an invited speaker on this subject at international conferences.
The third major contribution has been the use of computerized technology to administer cognitive tests for use in clinical trials and exploring the feasibility of performing these tests in the home environment when individuals cannot come to the clinic (Rentz et al 2016; 2017). I am currently working on the development of digital pen technology for detecting deficits in cognitive processing and decision-making that may be sensitive to early cognitive decline in neurodegenerative diseases. I have begun to partner with PCP and geriatric practices, with the help of two BWH behavioral neurologists and the Alzheimer’s Association, to develop a lecture series and to determine the usefulness of digital technology for conducting easy to administer cognitive tests in the PCP environment for dementia assessment.
In the past 2 years, I have had the privilege of developing a Community Service Outreach Initiative that provides education about Alzheimer’s disease and clinical trials in underserved Black and Hispanic communities in the Boston area. We have partnered with the NAACP Health Committee, Religious Leaders and State Representatives and are making efforts to reduce disparities in health care and increase opportunities for clinical trial participation.
Finally, and most importantly, I have had the privilege of mentoring and training the next generation of neuropsychologists for both clinical practice and clinical research. Several of these trainees have gone on to join the faculty at Harvard (Pam Friedman PsyD, Meghan Searl PhD, Kim Wilmett PhD), and two have received NIA K23 and Alzheimer’s Association awards as well as promotions to Assistant Professor (Rebecca Amariglio, PhD and Kathryn Papp, PhD). One research trainee (Elizabeth Mormino, PhD) has been asked to join the faculty of Stanford University and to head their research efforts in normal aging and preclinical Alzheimer’s disease. The privilege of mentoring these remarkable women and observing their growing reputation in the national and international arena will always be my most treasured legacy.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. P01AG036694 (SPERLING, REISA A.) Jul 15, 2010 - Mar 31, 2025
    NIH
    Impact of Amyloid and Tau on the Aging Brain: The Harvard Aging Brain Study
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Jutten RJ, Papp KV, Hendrix S, Ellison N, Langbaum JB, Donohue MC, Hassenstab J, Maruff P, Rentz DM, Harrison J, Cummings J, Scheltens P, Sikkes SAM. Why a clinical trial is as good as its outcome measure: A framework for the selection and use of cognitive outcome measures for clinical trials of Alzheimer's disease. Alzheimers Dement. 2022 Sep 10. PMID: 36086926.
    Citations:    Fields:    
  2. Yau WW, Shirzadi Z, Yang HS, Ikoba AP, Rabin JS, Properzi MJ, Kirn DR, Schultz AP, Rentz DM, Johnson KA, Sperling RA, Chhatwal JP. Tau Mediates Synergistic Influence of Vascular Risk and Aß on Cognitive Decline. Ann Neurol. 2022 Nov; 92(5):745-755. PMID: 35880989; PMCID: PMC9650958.
    Citations:    Fields:    
  3. Hampton OL, Mukherjee S, Properzi MJ, Schultz AP, Crane PK, Gibbons LE, Hohman TJ, Maruff P, Lim YY, Amariglio RE, Papp KV, Johnson KA, Rentz DM, Sperling RA, Buckley RF. Harmonizing the preclinical Alzheimer cognitive composite for multicohort studies. Neuropsychology. 2022 Jul 21. PMID: 35862098.
    Citations:    Fields:    
  4. Pruzin JJ, Klein H, Rabin JS, Schultz AP, Kirn DR, Yang HS, Buckley RF, Scott MR, Properzi M, Rentz DM, Johnson KA, Sperling RA, Chhatwal JP. Physical activity is associated with increased resting-state functional connectivity in networks predictive of cognitive decline in clinically unimpaired older adults. Alzheimers Dement (Amst). 2022; 14(1):e12319. PMID: 35821672; PMCID: PMC9261733.
    Citations:    
  5. Gershon RC, Sliwinski MJ, Mangravite L, King JW, Kaat AJ, Weiner MW, Rentz DM. The Mobile Toolbox for monitoring cognitive function. Lancet Neurol. 2022 07; 21(7):589-590. PMID: 35716687.
    Citations:    Fields:    Translation:Humans
  6. Wessels AM, Rentz DM, Case M, Lauzon S, Sims JR. Integrated Alzheimer's Disease Rating Scale: Clinically meaningful change estimates. Alzheimers Dement (N Y). 2022; 8(1):e12312. PMID: 35676941; PMCID: PMC9169866.
    Citations: 1     
  7. Rabin JS, Pruzin J, Scott M, Yang HS, Hampton O, Hsieh S, Schultz AP, Buckley RF, Hedden T, Rentz D, Johnson KA, Sperling RA, Chhatwal JP. Association of ß-Amyloid and Vascular Risk on Longitudinal Patterns of Brain Atrophy. Neurology. 2022 Apr 26. PMID: 35473760; PMCID: PMC9302937.
    Citations:    Fields:    
  8. Farrell ME, Papp KV, Buckley RF, Jacobs HIL, Schultz AP, Properzi MJ, Vannini P, Hanseeuw BJ, Rentz DM, Johnson KA, Sperling RA. Association of Emerging ß-Amyloid and Tau Pathology With Early Cognitive Changes in Clinically Normal Older Adults. Neurology. 2022 04 12; 98(15):e1512-e1524. PMID: 35338074; PMCID: PMC9012271.
    Citations:    Fields:    Translation:Humans
  9. Prokopiou PC, Engels-Domínguez N, Papp KV, Scott MR, Schultz AP, Schneider C, Farrell ME, Buckley RF, Quiroz YT, El Fakhri G, Rentz DM, Sperling RA, Johnson KA, Jacobs HIL. Lower novelty-related locus coeruleus function is associated with Aß-related cognitive decline in clinically healthy individuals. Nat Commun. 2022 03 23; 13(1):1571. PMID: 35322012; PMCID: PMC8943159.
    Citations: 1     Fields:    Translation:Animals
  10. Alegret M, Sotolongo-Grau O, de Antonio EE, Pérez-Cordón A, Orellana A, Espinosa A, Gil S, Jiménez D, Ortega G, Sanabria A, Roberto N, Hernández I, Rosende-Roca M, Tartari JP, Alarcon-Martin E, de Rojas I, Montrreal L, Morató X, Cano A, Rentz DM, Tárraga L, Ruiz A, Valero S, Marquié M, Boada M. Automatized FACEmemory® scoring is related to Alzheimer's disease phenotype and biomarkers in early-onset mild cognitive impairment: the BIOFACE cohort. Alzheimers Res Ther. 2022 03 18; 14(1):43. PMID: 35303916; PMCID: PMC8933921.
    Citations:    Fields:    Translation:Humans
  11. Willey B, Mimmack K, Gagliardi G, Dossett ML, Wang S, Udeogu OJ, Donovan NJ, Gatchel JR, Quiroz YT, Amariglio R, Liu CH, Hyun S, ElTohamy A, Rentz D, Sperling RA, Marshall GA, Vannini P. Racial and socioeconomic status differences in stress, posttraumatic growth, and mental health in an older adult cohort during the COVID-19 pandemic. EClinicalMedicine. 2022 Mar; 45:101343. PMID: 35291556; PMCID: PMC8917957.
    Citations:    
  12. Quiroz YT, Solis M, Aranda MP, Arbaje AI, Arroyo-Miranda M, Cabrera LY, Carrasquillo MM, Corrada MM, Crivelli L, Diminich ED, Dorsman KA, Gonzales M, González HM, Gonzalez-Seda AL, Grinberg LT, Guerrero LR, Hill CV, Jimenez-Velazquez IZ, Guerra JJL, Lopera F, Maestre G, Medina LD, O'Bryant S, Peñaloza C, Pinzon MM, Mavarez RVP, Pluim CF, Raman R, Rascovsky K, Rentz DM, Reyes Y, Rosselli M, Tansey MG, Vila-Castelar C, Zuelsdorff M, Carrillo M, Sexton C. Addressing the disparities in dementia risk, early detection and care in Latino populations: Highlights from the second Latinos & Alzheimer's Symposium. Alzheimers Dement. 2022 Sep; 18(9):1677-1686. PMID: 35199931; PMCID: PMC9399296.
    Citations:    Fields:    
  13. Grober E, Lipton RB, Sperling RA, Papp KV, Johnson KA, Rentz DM, Veroff AE, Aisen PS, Ezzati A. Associations of Stages of Objective Memory Impairment With Amyloid PET and Structural MRI: The A4 Study. Neurology. 2022 03 29; 98(13):e1327-e1336. PMID: 35197359; PMCID: PMC8967421.
    Citations:    Fields:    Translation:Humans
  14. Munro CE, Buckley R, Vannini P, DeMuro C, Sperling R, Rentz DM, Johnson K, Gatchel JR, Amariglio R. Longitudinal Trajectories of Participant- and Study Partner-Rated Cognitive Decline, in Relation to Alzheimer's Disease Biomarkers and Mood Symptoms. Front Aging Neurosci. 2021; 13:806432. PMID: 35173601; PMCID: PMC8841868.
    Citations:    
  15. Jutten RJ, Rentz DM, Fu JF, Mayblyum DV, Amariglio RE, Buckley RF, Properzi MJ, Maruff P, Stark CE, Yassa MA, Johnson KA, Sperling RA, Papp KV. Monthly At-Home Computerized Cognitive Testing to Detect Diminished Practice Effects in Preclinical Alzheimer's Disease. Front Aging Neurosci. 2021; 13:800126. PMID: 35095476; PMCID: PMC8792465.
    Citations: 1     
  16. Dubbelman MA, Sanchez J, Schultz AP, Rentz DM, Amariglio RE, Sikkes SAM, Sperling RA, Johnson KA, Marshall GA. Everyday Functioning and Entorhinal and Inferior Temporal Tau Burden in Cognitively Normal Older Adults. J Prev Alzheimers Dis. 2022; 9(4):801-808. PMID: 36281685.
    Citations:    Fields:    Translation:Humans
  17. Rhodus EK, Aisen P, Grill JD, Rentz DM, Petersen RC, Sperling RA, Salloway SP, Pierce D, Raman R. Alzheimer's Disease Clinical Trial Research Adaptation Following COVID-19 Pandemic Onset: National Sample of Alzheimer's Clinical Trial Consortium Sites. J Prev Alzheimers Dis. 2022; 9(4):665-671. PMID: 36281670; PMCID: PMC9491649.
    Citations:    Fields:    Translation:HumansPHPublic Health
  18. Wessels AM, Belger M, Johnston JA, Yu Y, Rentz DM, Dowsett SA, Chandler J. Demonstration of Clinical Meaningfulness of the Integrated Alzheimer's Disease Rating Scale (iADRS): Association Between Change in iADRS Scores and Patient and Caregiver Health Outcomes. J Alzheimers Dis. 2022; 88(2):577-588. PMID: 35694928; PMCID: PMC9398086.
    Citations:    Fields:    Translation:Humans
  19. Reynolds GO, Manning L, Kirn D, Klein H, Hampton O, Burke O, Buckley R, Rentz D, Sperling R, Marshall GA, Amariglio RE. Subjective Cognitive Decline in a Registry Sample: Relation to Psychiatric History, Loneliness, and Personality. J Prev Alzheimers Dis. 2022; 9(3):435-440. PMID: 35841244; PMCID: PMC8940594.
    Citations:    Fields:    Translation:Humans
  20. Grober E, Papp KV, Rentz DM, Sperling RA, Johnson KA, Amariglio RE, Schultz A, Lipton RB, Ezzati A. Neuroimaging correlates of Stages of Objective Memory Impairment (SOMI) system. Alzheimers Dement (Amst). 2021; 13(1):e12224. PMID: 35005192; PMCID: PMC8719429.
    Citations: 1     
  21. Weintraub S, Karpouzian-Rogers T, Peipert JD, Nowinski C, Slotkin J, Wortman K, Ho E, Rogalski E, Carlsson C, Giordani B, Goldstein F, Lucas J, Manly JJ, Rentz D, Salmon D, Snitz B, Dodge HH, Riley M, Eldes F, Ustsinovich V, Gershon R. ARMADA: Assessing reliable measurement in Alzheimer's disease and cognitive aging project methods. Alzheimers Dement. 2022 Aug; 18(8):1449-1460. PMID: 34786833; PMCID: PMC9110564.
    Citations:    Fields:    
  22. Papp KV, Samaroo A, Chou HC, Buckley R, Schneider OR, Hsieh S, Soberanes D, Quiroz Y, Properzi M, Schultz A, García-Magariño I, Marshall GA, Burke JG, Kumar R, Snyder N, Johnson K, Rentz DM, Sperling RA, Amariglio RE. Unsupervised mobile cognitive testing for use in preclinical Alzheimer's disease. Alzheimers Dement (Amst). 2021; 13(1):e12243. PMID: 34621977; PMCID: PMC8481881.
    Citations: 1     
  23. Jacobs HIL, Becker JA, Kwong K, Engels-Domínguez N, Prokopiou PC, Papp KV, Properzi M, Hampton OL, d'Oleire Uquillas F, Sanchez JS, Rentz DM, El Fakhri G, Normandin MD, Price JC, Bennett DA, Sperling RA, Johnson KA. In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer's disease pathology and cognitive decline. Sci Transl Med. 2021 Sep 22; 13(612):eabj2511. PMID: 34550726; PMCID: PMC8641759.
    Citations: 14     Fields:    Translation:Humans
  24. Sevinc G, Rusche J, Wong B, Datta T, Kaufman R, Gutz SE, Schneider M, Todorova N, Gaser C, Thomalla G, Rentz D, Dickerson BD, Lazar SW. Mindfulness Training Improves Cognition and Strengthens Intrinsic Connectivity Between the Hippocampus and Posteromedial Cortex in Healthy Older Adults. Front Aging Neurosci. 2021; 13:702796. PMID: 34512305; PMCID: PMC8430251.
    Citations: 3     
  25. Salinas J, O'Donnell A, Kojis DJ, Pase MP, DeCarli C, Rentz DM, Berkman LF, Beiser A, Seshadri S. Association of Social Support With Brain Volume and Cognition. JAMA Netw Open. 2021 08 02; 4(8):e2121122. PMID: 34398201; PMCID: PMC8369356.
    Citations: 3     Fields:    Translation:Humans
  26. Raman R, Quiroz YT, Langford O, Choi J, Ritchie M, Baumgartner M, Rentz D, Aggarwal NT, Aisen P, Sperling R, Grill JD. Disparities by Race and Ethnicity Among Adults Recruited for a Preclinical Alzheimer Disease Trial. JAMA Netw Open. 2021 07 01; 4(7):e2114364. PMID: 34228129; PMCID: PMC8261604.
    Citations: 10     Fields:    Translation:Humans
  27. Rentz DM, Wessels AM, Annapragada AV, Berger AK, Edgar CJ, Gold M, Miller DS, Randolph C, Ryan JM, Wunderlich G, Zoschg MC, Trépel D, Knopman DS, Staffaroni AM, Bain LJ, Carrillo MC, Weber CJ. Building clinically relevant outcomes across the Alzheimer's disease spectrum. Alzheimers Dement (N Y). 2021; 7(1):e12181. PMID: 34195350.
    Citations:    
  28. Yang HS, Zhang C, Carlyle BC, Zhen SY, Trombetta BA, Schultz AP, Pruzin JJ, Fitzpatrick CD, Yau WW, Kirn DR, Rentz DM, Arnold SE, Johnson KA, Sperling RA, Chhatwal JP, Tanzi RE. Plasma IL-12/IFN-? axis predicts cognitive trajectories in cognitively unimpaired older adults. Alzheimers Dement. 2022 04; 18(4):645-653. PMID: 34160128; PMCID: PMC8695625.
    Citations: 7     Fields:    Translation:Humans
  29. Mayblyum DV, Becker JA, Jacobs HIL, Buckley RF, Schultz AP, Sepulcre J, Sanchez JS, Rubinstein ZB, Katz SR, Moody KA, Vannini P, Papp KV, Rentz DM, Price JC, Sperling RA, Johnson KA, Hanseeuw BJ. Comparing PET and MRI Biomarkers Predicting Cognitive Decline in Preclinical Alzheimer Disease. Neurology. 2021 May 05. PMID: 33952655.
    Citations: 4     Fields:    
  30. Babulal GM, Torres VL, Acosta D, Agüero C, Aguilar-Navarro S, Amariglio R, Ussui JA, Baena A, Bocanegra Y, Brucki SMD, Bustin J, Cabrera DM, Custodio N, Diaz MM, Peñailillo LD, Franco I, Gatchel JR, Garza-Naveda AP, González Lara M, Gutiérrez-Gutiérrez L, Guzmán-Vélez E, Hanseeuw BJ, Jimenez-Velazquez IZ, Rodríguez TL, Llibre-Guerra J, Marquine MJ, Martinez J, Medina LD, Miranda-Castillo C, Morlett Paredes A, Munera D, Nuñez-Herrera A, de Oliveira MO, Palmer-Cancel SJ, Pardilla-Delgado E, Perales-Puchalt J, Pluim C, Ramirez-Gomez L, Rentz DM, Rivera-Fernández C, Rosselli M, Serrano CM, Suing-Ortega MJ, Slachevsky A, Soto-Añari M, Sperling RA, Torrente F, Thumala D, Vannini P, Vila-Castelar C, Yañez-Escalante T, Quiroz YT. The impact of COVID-19 on the well-being and cognition of older adults living in the United States and Latin America. EClinicalMedicine. 2021 May; 35:100848. PMID: 33997742; PMCID: PMC8100067.
    Citations: 5     
  31. Rentz DM, Papp KV, Mayblyum DV, Sanchez JS, Klein H, Souillard-Mandar W, Sperling RA, Johnson KA. Association of Digital Clock Drawing With PET Amyloid and Tau Pathology in Normal Older Adults. Neurology. 2021 04 06; 96(14):e1844-e1854. PMID: 33589537.
    Citations: 8     Fields:    Translation:Humans
  32. Sanchez JS, Becker JA, Jacobs HIL, Hanseeuw BJ, Jiang S, Schultz AP, Properzi MJ, Katz SR, Beiser A, Satizabal CL, O'Donnell A, DeCarli C, Killiany R, El Fakhri G, Normandin MD, Gómez-Isla T, Quiroz YT, Rentz DM, Sperling RA, Seshadri S, Augustinack J, Price JC, Johnson KA. The cortical origin and initial spread of medial temporal tauopathy in Alzheimer's disease assessed with positron emission tomography. Sci Transl Med. 2021 01 20; 13(577). PMID: 33472953; PMCID: PMC7978042.
    Citations: 27     Fields:    Translation:Humans
  33. Samaroo A, Amariglio RE, Burnham S, Sparks P, Properzi M, Schultz AP, Buckley R, Johnson KA, Sperling RA, Rentz DM, Papp KV. Diminished Learning Over Repeated Exposures (LORE) in preclinical Alzheimer's disease. Alzheimers Dement (Amst). 2020; 12(1):e12132. PMID: 33426266; PMCID: PMC7784542.
    Citations: 7     
  34. Amariglio RE, Sikkes SAM, Marshall GA, Buckley RF, Gatchel JR, Johnson KA, Rentz DM, Donohue MC, Raman R, Sun CK, Yaari R, Holdridge KC, Sims JR, Grill JD, Aisen PS, Sperling RA. Item-Level Investigation of Participant and Study Partner Report on the Cognitive Function Index from the A4 Study Screening Data. J Prev Alzheimers Dis. 2021; 8(3):257-262. PMID: 34101781; PMCID: PMC8240963.
    Citations: 3     Fields:    Translation:Humans
  35. Papp KV, Rentz DM, Maruff P, Sun CK, Raman R, Donohue MC, Schembri A, Stark C, Yassa MA, Wessels AM, Yaari R, Holdridge KC, Aisen PS, Sperling RA. The Computerized Cognitive Composite (C3) in an Alzheimer's Disease Secondary Prevention Trial. J Prev Alzheimers Dis. 2021; 8(1):59-67. PMID: 33336226.
    Citations: 12     Fields:    Translation:HumansPHPublic Health
  36. Farrell ME, Jiang S, Schultz AP, Properzi MJ, Price JC, Becker JA, Jacobs HIL, Hanseeuw BJ, Rentz DM, Villemagne VL, Papp KV, Mormino EC, Betensky RA, Johnson KA, Sperling RA, Buckley RF. Defining the Lowest Threshold for Amyloid-PET to Predict Future Cognitive Decline and Amyloid Accumulation. Neurology. 2021 01 26; 96(4):e619-e631. PMID: 33199430; PMCID: PMC7905788.
    Citations: 11     Fields:    Translation:Humans
  37. Marshall GA, Sikkes SAM, Amariglio RE, Gatchel JR, Rentz DM, Johnson KA, Langford O, Sun CK, Donohue MC, Raman R, Aisen PS, Sperling RA, Galasko DR. Instrumental activities of daily living, amyloid, and cognition in cognitively normal older adults screening for the A4 Study. Alzheimers Dement (Amst). 2020; 12(1):e12118. PMID: 33163609; PMCID: PMC7596668.
    Citations: 2     
  38. Dubbelman MA, Jutten RJ, Tomaszewski Farias SE, Amariglio RE, Buckley RF, Visser PJ, Rentz DM, Johnson KA, Properzi MJ, Schultz A, Donovan N, Gatchell JR, Teunissen CE, Van Berckel BNM, Van der Flier WM, Sperling RA, Papp KV, Scheltens P, Marshall GA, Sikkes SAM. Decline in cognitively complex everyday activities accelerates along the Alzheimer's disease continuum. Alzheimers Res Ther. 2020 10 29; 12(1):138. PMID: 33121534.
    Citations: 1     Fields:    Translation:Humans
  39. Jutten RJ, Sikkes SAM, Amariglio RE, Buckley RF, Properzi MJ, Marshall GA, Rentz DM, Johnson KA, Teunissen CE, Van Berckel BNM, Van der Flier WM, Scheltens P, Sperling RA, Papp KV. Identifying Sensitive Measures of Cognitive Decline at Different Clinical Stages of Alzheimer's Disease. J Int Neuropsychol Soc. 2021 05; 27(5):426-438. PMID: 33046162; PMCID: PMC8041916.
    Citations: 8     Fields:    Translation:Humans
  40. Hanseeuw BJ, Jonas V, Jackson J, Betensky RA, Rentz DM, Johnson KA, Sperling RA, Donovan NJ. Correction: Association of anxiety with subcortical amyloidosis in cognitively normal older adults. Mol Psychiatry. 2020 Oct; 25(10):2644. PMID: 30538309.
    Citations: 2     Fields:    
  41. Vila-Castelar C, Muñoz N, Papp KV, Amariglio RE, Baena A, Guzmán-Vélez E, Bocanegra Y, Sanchez JS, Reiman EM, Johnson KA, Sperling RA, Lopera F, Rentz DM, Quiroz YT. The Latin American Spanish version of the Face-Name Associative Memory Exam is sensitive to cognitive and pathological changes in preclinical autosomal dominant Alzheimer's disease. Alzheimers Res Ther. 2020 09 10; 12(1):104. PMID: 32912283.
    Citations: 1     Fields:    Translation:Humans
  42. Buckley RF, Scott MR, Jacobs HIL, Schultz AP, Properzi MJ, Amariglio RE, Hohman TJ, Mayblyum DV, Rubinstein ZB, Manning L, Hanseeuw BJ, Mormino EC, Rentz DM, Johnson KA, Sperling RA. Sex Mediates Relationships Between Regional Tau Pathology and Cognitive Decline. Ann Neurol. 2020 11; 88(5):921-932. PMID: 32799367; PMCID: PMC7581543.
    Citations: 9     Fields:    Translation:Humans
  43. Rabin JS, Neal TE, Nierle HE, Sikkes SAM, Buckley RF, Amariglio RE, Papp KV, Rentz DM, Schultz AP, Johnson KA, Sperling RA, Hedden T. Multiple markers contribute to risk of progression from normal to mild cognitive impairment. Neuroimage Clin. 2020; 28:102400. PMID: 32919366; PMCID: PMC7491146.
    Citations: 3     Fields:    Translation:Humans
  44. Norton DJ, Parra MA, Sperling RA, Baena A, Guzman-Velez E, Jin DS, Andrea N, Khang J, Schultz A, Rentz DM, Pardilla-Delgado E, Fuller J, Johnson K, Reiman EM, Lopera F, Quiroz YT. Visual short-term memory relates to tau and amyloid burdens in preclinical autosomal dominant Alzheimer's disease. Alzheimers Res Ther. 2020 08 21; 12(1):99. PMID: 32825838.
    Citations: 3     Fields:    Translation:Humans
  45. Guzmán-Vélez E, Martínez J, Papp K, Baena A, Vila-Castelar C, Artola A, Schultz AP, Bocanegra Y, Sanchez J, Rentz D, Tariot PN, Reiman EM, Sperling R, Johnson KA, Lopera F, Quiroz YT. Associative memory and in vivo brain pathology in asymptomatic presenilin-1 E280A carriers. Neurology. 2020 09 08; 95(10):e1312-e1321. PMID: 32611637.
    Citations: 2     Fields:    Translation:Humans
  46. Burnham SC, Laws SM, Budgeon CA, Doré V, Porter T, Bourgeat P, Buckley RF, Murray K, Ellis KA, Turlach BA, Salvado O, Ames D, Martins RN, Rentz D, Masters CL, Rowe CC, Villemagne VL. Impact of APOE-e4 carriage on the onset and rates of neocortical Aß-amyloid deposition. Neurobiol Aging. 2020 11; 95:46-55. PMID: 32750666.
    Citations: 8     Fields:    Translation:Humans
  47. Rentz DM, Papp KV. Commentary on Composite cognitive and functional measures for early stage Alzheimer's disease trials. Alzheimers Dement (Amst). 2020; 12(1):e12012. PMID: 33521233.
    Citations:    
  48. Rentz DM, Wessels AM, Bain LJ, Weber CJ, Carrillo MC. Clinical meaningfulness addressed at Alzheimer's Association Research Roundtable. Alzheimers Dement. 2020 05; 16(5):814. PMID: 32386282.
    Citations: 1     Fields:    Translation:Humans
  49. Jacobs HIL, Augustinack JC, Schultz AP, Hanseeuw BJ, Locascio J, Amariglio RE, Papp KV, Rentz DM, Sperling RA, Johnson KA. The presubiculum links incipient amyloid and tau pathology to memory function in older persons. Neurology. 2020 05 05; 94(18):e1916-e1928. PMID: 32273431.
    Citations: 7     Fields:    Translation:Humans
  50. Alegret M, Muñoz N, Roberto N, Rentz DM, Valero S, Gil S, Marquié M, Hernández I, Riveros C, Sanabria A, Perez-Cordon A, Espinosa A, Ortega G, Mauleón A, Abdelnour C, Rosende-Roca M, Papp KV, Orellana A, Benaque A, Tarraga L, Ruiz A, Boada M. A computerized version of the Short Form of the Face-Name Associative Memory Exam (FACEmemory®) for the early detection of Alzheimer's disease. Alzheimers Res Ther. 2020 03 16; 12(1):25. PMID: 32178724.
    Citations: 8     Fields:    Translation:Humans
  51. Rabin JS, Shirzadi Z, Swardfager W, MacIntosh BJ, Schultz A, Yang HS, Buckley RF, Gatchel JR, Kirn D, Pruzin JJ, Hedden T, Lipsman N, Rentz DM, Black SE, Johnson KA, Sperling RA, Chhatwal JP. Amyloid-beta burden predicts prospective decline in body mass index in clinically normal adults. Neurobiol Aging. 2020 09; 93:124-130. PMID: 32249013.
    Citations: 6     Fields:    Translation:Humans
  52. Biddle KD, Jacobs HIL, d'Oleire Uquillas F, Zide BS, Kirn DR, Properzi MR, Rentz DM, Johnson KA, Sperling RA, Donovan NJ. Associations of Widowhood and ß-Amyloid With Cognitive Decline in Cognitively Unimpaired Older Adults. JAMA Netw Open. 2020 02 05; 3(2):e200121. PMID: 32101313.
    Citations: 13     Fields:    Translation:Humans
  53. Jessen F, Amariglio RE, Buckley RF, van der Flier WM, Han Y, Molinuevo JL, Rabin L, Rentz DM, Rodriguez-Gomez O, Saykin AJ, Sikkes SAM, Smart CM, Wolfsgruber S, Wagner M. The characterisation of subjective cognitive decline. Lancet Neurol. 2020 03; 19(3):271-278. PMID: 31958406.
    Citations: 152     Fields:    Translation:Humans
  54. Papp KV, Buckley R, Mormino E, Maruff P, Villemagne VL, Masters CL, Johnson KA, Rentz DM, Sperling RA, Amariglio RE. Clinical meaningfulness of subtle cognitive decline on longitudinal testing in preclinical AD. Alzheimers Dement. 2020 03; 16(3):552-560. PMID: 31759879.
    Citations: 29     Fields:    Translation:Humans
  55. Amariglio RE, Buckley RF, Rabin JS, Papp KV, Quiroz YT, Mormino EC, Sparks KP, Johnson KA, Rentz DM, Sperling RA. Examining Cognitive Decline Across Black and White Participants in the Harvard Aging Brain Study. J Alzheimers Dis. 2020; 75(4):1437-1446. PMID: 32417775; PMCID: PMC7397774.
    Citations: 7     Fields:    Translation:Humans
  56. Robinson RL, Rentz DM, Andrews JS, Zagar A, Kim Y, Bruemmer V, Schwartz RL, Ye W, Fillit HM. Costs of Early Stage Alzheimer's Disease in the United States: Cross-Sectional Analysis of a Prospective Cohort Study (GERAS-US)1. J Alzheimers Dis. 2020; 75(2):437-450. PMID: 32250304.
    Citations: 8     Fields:    Translation:Humans
  57. Konishi K, Cherkerzian S, Aroner S, Jacobs EG, Rentz DM, Remington A, Aizley H, Hornig M, Klibanski A, Goldstein JM. Impact of BDNF and sex on maintaining intact memory function in early midlife. Neurobiol Aging. 2020 04; 88:137-149. PMID: 31948671.
    Citations: 4     Fields:    Translation:Humans
  58. Gatchel JR, Lopera F, Norton DJ, Baena A, Guzman-Velez E, Sanchez JS, d'Oleire Uquillas F, Schultz A, Vannini P, Artola A, Amariglio RE, Rentz DM, Tariot PN, Reiman EM, Johnson KA, Sperling RA, Marshall GA, Quiroz YT. Association of subjective cognitive decline with markers of brain pathology in preclinical autosomal dominant Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2020 03; 91(3):330-332. PMID: 31874859; PMCID: PMC7397724.
    Citations: 5     Fields:    Translation:Humans
  59. Vila-Castelar C, Papp KV, Amariglio RE, Torres VL, Baena A, Gomez D, Rendon J, Samaroo A, Lopera F, Rentz DM, Quiroz YT. Validation of the Latin American Spanish version of the face-name associative memory exam in a Colombian Sample. Clin Neuropsychol. 2020 12; 34(sup1):1-12. PMID: 31851865.
    Citations: 5     Fields:    Translation:Humans
  60. Vannini P, d'Oleire Uquillas F, Jacobs HIL, Sepulcre J, Gatchel J, Amariglio RE, Hanseeuw B, Papp KV, Hedden T, Rentz DM, Pascual-Leone A, Johnson KA, Sperling RA. Decreased meta-memory is associated with early tauopathy in cognitively unimpaired older adults. Neuroimage Clin. 2019; 24:102097. PMID: 31795044.
    Citations: 3     Fields:    Translation:Humans
  61. Rabin JS, Klein H, Kirn DR, Schultz AP, Yang HS, Hampton O, Jiang S, Buckley RF, Viswanathan A, Hedden T, Pruzin J, Yau WW, Guzmán-Vélez E, Quiroz YT, Properzi M, Marshall GA, Rentz DM, Johnson KA, Sperling RA, Chhatwal JP. Associations of Physical Activity and ß-Amyloid With Longitudinal Cognition and Neurodegeneration in Clinically Normal Older Adults. JAMA Neurol. 2019 Oct 01; 76(10):1203-1210. PMID: 31312836; PMCID: PMC6635892.
    Citations: 25     Fields:    
  62. Buckley RF, Sikkes S, Villemagne VL, Mormino EC, Rabin JS, Burnham S, Papp KV, Doré V, Masters CL, Properzi MJ, Schultz AP, Johnson KA, Rentz DM, Sperling RA, Amariglio RE. Using subjective cognitive decline to identify high global amyloid in community-based samples: A cross-cohort study. Alzheimers Dement (Amst). 2019 Dec; 11:670-678. PMID: 31673597; PMCID: PMC6816447.
    Citations: 4     
  63. Bettcher BM, Gross AL, Gavett BE, Widaman KF, Fletcher E, Dowling NM, Buckley RF, Arenaza-Urquijo EM, Zahodne LB, Hohman TJ, Vonk JMJ, Rentz DM, Mungas D. Dynamic change of cognitive reserve: associations with changes in brain, cognition, and diagnosis. Neurobiol Aging. 2019 11; 83:95-104. PMID: 31585371.
    Citations: 8     Fields:    Translation:Humans
  64. Gatchel JR, Rabin JS, Buckley RF, Locascio JJ, Quiroz YT, Yang HS, Vannini P, Amariglio RE, Rentz DM, Properzi M, Donovan NJ, Blacker D, Johnson KA, Sperling RA, Marshall GA. Longitudinal Association of Depression Symptoms With Cognition and Cortical Amyloid Among Community-Dwelling Older Adults. JAMA Netw Open. 2019 08 02; 2(8):e198964. PMID: 31397865.
    Citations: 24     Fields:    Translation:Humans
  65. Hanseeuw BJ, Betensky RA, Jacobs HIL, Schultz AP, Sepulcre J, Becker JA, Cosio DMO, Farrell M, Quiroz YT, Mormino EC, Buckley RF, Papp KV, Amariglio RA, Dewachter I, Ivanoiu A, Huijbers W, Hedden T, Marshall GA, Chhatwal JP, Rentz DM, Sperling RA, Johnson K. Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease: A Longitudinal Study. JAMA Neurol. 2019 Aug 01; 76(8):915-924. PMID: 31157827; PMCID: PMC6547132.
    Citations: 185     Fields:    
  66. Chhatwal JP, Schultz AP, Hedden T, Boot BP, Wigman S, Rentz D, Johnson KA, Sperling RA. Anticholinergic Amnesia is Mediated by Alterations in Human Network Connectivity Architecture. Cereb Cortex. 2019 07 22; 29(8):3445-3456. PMID: 30192928; PMCID: PMC6644870.
    Citations: 3     Fields:    Translation:Humans
  67. Bott NT, Madero EN, Glenn JM, Lange AR, Anderson JJ, Newton DO, Brennan AH, Buffalo EA, Rentz DM, Zola SM. Device-Embedded Cameras for Eye Tracking-Based Cognitive Assessment: Implications for Teleneuropsychology. Telemed J E Health. 2020 04; 26(4):477-481. PMID: 31161968.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  68. Biddle KD, d'Oleire Uquillas F, Jacobs HIL, Zide B, Kirn DR, Rentz DM, Johnson KA, Sperling RA, Donovan NJ. Social Engagement and Amyloid-ß-Related Cognitive Decline in Cognitively Normal Older Adults. Am J Geriatr Psychiatry. 2019 11; 27(11):1247-1256. PMID: 31248770.
    Citations: 13     Fields:    Translation:Humans
  69. Buckley RF, Mormino EC, Rabin JS, Hohman TJ, Landau S, Hanseeuw BJ, Jacobs HIL, Papp KV, Amariglio RE, Properzi MJ, Schultz AP, Kirn D, Scott MR, Hedden T, Farrell M, Price J, Chhatwal J, Rentz DM, Villemagne VL, Johnson KA, Sperling RA. Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured by Positron Emission Tomography in Clinically Normal Older Adults. JAMA Neurol. 2019 05 01; 76(5):542-551. PMID: 30715078; PMCID: PMC6515599.
    Citations: 84     Fields:    Translation:Humans
  70. Buckley RF, Mormino EC, Chhatwal J, Schultz AP, Rabin JS, Rentz DM, Acar D, Properzi MJ, Dumurgier J, Jacobs H, Gomez-Isla T, Johnson KA, Sperling RA, Hanseeuw BJ. Associations between baseline amyloid, sex, and APOE on subsequent tau accumulation in cerebrospinal fluid. Neurobiol Aging. 2019 06; 78:178-185. PMID: 30947113; PMCID: PMC6545139.
    Citations: 20     Fields:    Translation:Humans
  71. Halawa OA, Gatchel JR, Amariglio RE, Rentz DM, Sperling RA, Johnson KA, Marshall GA. Inferior and medial temporal tau and cortical amyloid are associated with daily functional impairment in Alzheimer's disease. Alzheimers Res Ther. 2019 01 31; 11(1):14. PMID: 30704519; PMCID: PMC6357436.
    Citations: 9     Fields: