Harvard Catalyst Profiles

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Philip Leder, M.D.



Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Leder P. Retrospective. Marshall Warren Nirenberg (1927-2010). Science. 2010 Feb 19; 327(5968):972. PMID: 20167780.
    Citations: 2     Fields:    
  2. Ravi D, Wiles AM, Bhavani S, Ruan J, Leder P, Bishop AJ. A network of conserved damage survival pathways revealed by a genomic RNAi screen. PLoS Genet. 2009 Jun; 5(6):e1000527. PMID: 19543366.
    Citations: 27     Fields:    Translation:AnimalsCells
  3. Zhou F, Leder P, Zuniga A, Dettenhofer M. Formin1 disruption confers oligodactylism and alters Bmp signaling. Hum Mol Genet. 2009 Jul 01; 18(13):2472-82. PMID: 19383632.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  4. Babbe H, McMenamin J, Hobeika E, Wang J, Rodig SJ, Reth M, Leder P. Genomic instability resulting from Blm deficiency compromises development, maintenance, and function of the B cell lineage. J Immunol. 2009 Jan 01; 182(1):347-60. PMID: 19109166.
    Citations: 9     Fields:    Translation:AnimalsCells
  5. Li X, Ito M, Zhou F, Youngson N, Zuo X, Leder P, Ferguson-Smith AC. A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints. Dev Cell. 2008 Oct; 15(4):547-57. PMID: 18854139.
    Citations: 179     Fields:    Translation:AnimalsCells
  6. Dettenhofer M, Zhou F, Leder P. Formin 1-isoform IV deficient cells exhibit defects in cell spreading and focal adhesion formation. PLoS One. 2008 Jun 18; 3(6):e2497. PMID: 18560567.
    Citations: 14     Fields:    Translation:AnimalsCells
  7. Leder A, McMenamin J, Zhou F, Moran JL, Beier DR, Leder P. Genome-wide SNP analysis of Tg.AC transgenic mice reveals an oncogenic collaboration between v-Ha-ras and Ink4a, which is absent in p53 deficiency. Oncogene. 2008 Apr 10; 27(17):2456-65. PMID: 17952114.
    Citations: 1     Fields:    Translation:AnimalsCells
  8. Li X, Leder P. Identifying genes preferentially expressed in undifferentiated embryonic stem cells. BMC Cell Biol. 2007 Aug 28; 8:37. PMID: 17725840.
    Citations: 7     Fields:    Translation:AnimalsCells
  9. Lu J, Ruhf ML, Perrimon N, Leder P. A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression. Proc Natl Acad Sci U S A. 2007 May 29; 104(22):9381-6. PMID: 17517653.
    Citations: 36     Fields:    Translation:AnimalsCells
  10. Babbe H, Chester N, Leder P, Reizis B. The Bloom's syndrome helicase is critical for development and function of the alphabeta T-cell lineage. Mol Cell Biol. 2007 Mar; 27(5):1947-59. PMID: 17210642.
    Citations: 13     Fields:    Translation:AnimalsCells
  11. Chester N, Babbe H, Pinkas J, Manning C, Leder P. Mutation of the murine Bloom's syndrome gene produces global genome destabilization. Mol Cell Biol. 2006 Sep; 26(17):6713-26. PMID: 16914751.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  12. Fantin VR, Leder P. Mitochondriotoxic compounds for cancer therapy. Oncogene. 2006 Aug 07; 25(34):4787-97. PMID: 16892091.
    Citations: 39     Fields:    Translation:HumansCells
  13. Fantin VR, St-Pierre J, Leder P. Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell. 2006 Jun; 9(6):425-34. PMID: 16766262.
    Citations: 415     Fields:    Translation:HumansAnimalsCells
  14. Zhou F, Leder P, Martin SS. Formin-1 protein associates with microtubules through a peptide domain encoded by exon-2. Exp Cell Res. 2006 Apr 15; 312(7):1119-26. PMID: 16480715.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  15. Ridgeway AG, McMenamin J, Leder P. P53 levels determine outcome during beta-catenin tumor initiation and metastasis in the mammary gland and male germ cells. Oncogene. 2006 Jun 15; 25(25):3518-27. PMID: 16434961.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  16. Fantin VR, Berardi MJ, Babbe H, Michelman MV, Manning CM, Leder P. A bifunctional targeted peptide that blocks HER-2 tyrosine kinase and disables mitochondrial function in HER-2-positive carcinoma cells. Cancer Res. 2005 Aug 01; 65(15):6891-900. PMID: 16061673.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  17. Leder A, McMenamin J, Fontaine K, Bishop A, Leder P. zeta-/- Thalassemic mice are affected by two modifying loci and display unanticipated somatic recombination leading to inherited variation. Hum Mol Genet. 2005 Mar 01; 14(5):615-25. PMID: 15649944.
    Citations:    Fields:    Translation:Animals
  18. Leder P. The formins: connecting embryonic pattern formation and hypofertility in the mouse. Ann N Y Acad Sci. 2004 Dec; 1038:75-9. PMID: 15838099.
    Citations: 2     Fields:    Translation:HumansAnimals
  19. Pinkas J, Martin SS, Leder P. Bcl-2-mediated cell survival promotes metastasis of EpH4 betaMEKDD mammary epithelial cells. Mol Cancer Res. 2004 Oct; 2(10):551-6. PMID: 15498929.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  20. Shigematsu H, Reizis B, Iwasaki H, Mizuno S, Hu D, Traver D, Leder P, Sakaguchi N, Akashi K. Plasmacytoid dendritic cells activate lymphoid-specific genetic programs irrespective of their cellular origin. Immunity. 2004 Jul; 21(1):43-53. PMID: 15345219.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  21. Martin SS, Ridgeway AG, Pinkas J, Lu Y, Reginato MJ, Koh EY, Michelman M, Daley GQ, Brugge JS, Leder P. A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth. Oncogene. 2004 Jun 03; 23(26):4641-5. PMID: 15064711.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  22. Fantin VR, Leder P. F16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell. Cancer Res. 2004 Jan 01; 64(1):329-36. PMID: 14729642.
    Citations: 9     Fields:    Translation:HumansCells
  23. McDaniel LD, Chester N, Watson M, Borowsky AD, Leder P, Schultz RA. Chromosome instability and tumor predisposition inversely correlate with BLM protein levels. DNA Repair (Amst). 2003 Dec 09; 2(12):1387-404. PMID: 14642567.
    Citations: 22     Fields:    Translation:Animals
  24. Ecsedy JA, Michaelson JS, Leder P. Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity. Mol Cell Biol. 2003 Feb; 23(3):950-60. PMID: 12529400.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  25. Weiss RS, Leder P, Vaziri C. Critical role for mouse Hus1 in an S-phase DNA damage cell cycle checkpoint. Mol Cell Biol. 2003 Feb; 23(3):791-803. PMID: 12529385.
    Citations: 26     Fields:    Translation:AnimalsCells
  26. Michaelson JS, Leder P. RNAi reveals anti-apoptotic and transcriptionally repressive activities of DAXX. J Cell Sci. 2003 Jan 15; 116(Pt 2):345-52. PMID: 12482920.
    Citations: 47     Fields:    Translation:HumansCells
  27. Leader B, Lim H, Carabatsos MJ, Harrington A, Ecsedy J, Pellman D, Maas R, Leder P. Formin-2, polyploidy, hypofertility and positioning of the meiotic spindle in mouse oocytes. Nat Cell Biol. 2002 Dec; 4(12):921-8. PMID: 12447394.
    Citations: 84     Fields:    Translation:AnimalsCells
  28. Leder A, Lebel M, Zhou F, Fontaine K, Bishop A, Leder P. Genetic interaction between the unstable v-Ha-RAS transgene (Tg.AC) and the murine Werner syndrome gene: transgene instability and tumorigenesis. Oncogene. 2002 Sep 26; 21(43):6657-68. PMID: 12242664.
    Citations: 2     Fields:    Translation:Animals
  29. Pinkas J, Leder P. MEK1 signaling mediates transformation and metastasis of EpH4 mammary epithelial cells independent of an epithelial to mesenchymal transition. Cancer Res. 2002 Aug 15; 62(16):4781-90. PMID: 12183438.
    Citations: 26     Fields:    Translation:AnimalsCells
  30. Fantin VR, Berardi MJ, Scorrano L, Korsmeyer SJ, Leder P. A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth. Cancer Cell. 2002 Jul; 2(1):29-42. PMID: 12150823.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  31. Gounari F, Aifantis I, Martin C, Fehling HJ, Hoeflinger S, Leder P, von Boehmer H, Reizis B. Tracing lymphopoiesis with the aid of a pTalpha-controlled reporter gene. Nat Immunol. 2002 May; 3(5):489-96. PMID: 11927910.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  32. Reizis B, Leder P. Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway. Genes Dev. 2002 Feb 01; 16(3):295-300. PMID: 11825871.
    Citations: 52     Fields:    Translation:AnimalsCells
  33. Weiss RS, Matsuoka S, Elledge SJ, Leder P. Hus1 acts upstream of chk1 in a mammalian DNA damage response pathway. Curr Biol. 2002 Jan 08; 12(1):73-7. PMID: 11790307.
    Citations: 30     Fields:    Translation:AnimalsCells
  34. Vollrath B, Pudney J, Asa S, Leder P, Fitzgerald K. Isolation of a murine homologue of the Drosophila neuralized gene, a gene required for axonemal integrity in spermatozoa and terminal maturation of the mammary gland. Mol Cell Biol. 2001 Nov; 21(21):7481-94. PMID: 11585928.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  35. Reizis B, Leder P. The upstream enhancer is necessary and sufficient for the expression of the pre-T cell receptor alpha gene in immature T lymphocytes. J Exp Med. 2001 Oct 01; 194(7):979-90. PMID: 11581319.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  36. Martin SS, Leder P. Human MCF10A mammary epithelial cells undergo apoptosis following actin depolymerization that is independent of attachment and rescued by Bcl-2. Mol Cell Biol. 2001 Oct; 21(19):6529-36. PMID: 11533241.
    Citations: 30     Fields:    Translation:HumansCells
  37. Michaelson JS, Leder P. beta-catenin is a downstream effector of Wnt-mediated tumorigenesis in the mammary gland. Oncogene. 2001 Aug 23; 20(37):5093-9. PMID: 11526497.
    Citations: 44     Fields:    Translation:AnimalsCells
  38. Vollrath B, Fitzgerald KJ, Leder P. A murine homologue of the Drosophila brainiac gene shows homology to glycosyltransferases and is required for preimplantation development of the mouse. Mol Cell Biol. 2001 Aug; 21(16):5688-97. PMID: 11463849.
    Citations: 6     Fields:    Translation:AnimalsCells
  39. Goodwin NC, Ishida Y, Hartford S, Wnek C, Bergstrom RA, Leder P, Schimenti JC. DelBank: a mouse ES-cell resource for generating deletions. Nat Genet. 2001 Aug; 28(4):310-1. PMID: 11479588.
    Citations: 7     Fields:    Translation:AnimalsCells
  40. Brodie SG, Xu X, Li C, Kuo A, Leder P, Deng CX. Inactivation of p53 tumor suppressor gene acts synergistically with c-neu oncogene in salivary gland tumorigenesis. Oncogene. 2001 Mar 22; 20(12):1445-54. PMID: 11313888.
    Citations: 5     Fields:    Translation:Animals
  41. Lebel M, Cardiff RD, Leder P. Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase. Cancer Res. 2001 Mar 01; 61(5):1816-9. PMID: 11280729.
    Citations: 18     Fields:    Translation:AnimalsCells
  42. Fitzgerald K, Harrington A, Leder P. Ras pathway signals are required for notch-mediated oncogenesis. Oncogene. 2000 Aug 31; 19(37):4191-8. PMID: 10980592.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  43. Lane TF, Lin C, Brown MA, Solomon E, Leder P. Gene replacement with the human BRCA1 locus: tissue specific expression and rescue of embryonic lethality in mice. Oncogene. 2000 Aug 24; 19(36):4085-90. PMID: 10962568.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  44. Weiss RS, Enoch T, Leder P. Inactivation of mouse Hus1 results in genomic instability and impaired responses to genotoxic stress. Genes Dev. 2000 Aug 01; 14(15):1886-98. PMID: 10921903.
    Citations: 52     Fields:    Translation:AnimalsCells
  45. Weinstein EJ, Leder P. The extracellular region of heregulin is sufficient to promote mammary gland proliferation and tumorigenesis but not apoptosis. Cancer Res. 2000 Jul 15; 60(14):3856-61. PMID: 10919660.
    Citations: 9