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Jeffrey Robert Friedman, M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gusev A, Shah MJ, Kenny EE, Ramachandran A, Lowe JK, Salit J, Lee CC, Levandowsky EC, Weaver TN, Doan QC, Peckham HE, McLaughlin SF, Lyons MR, Sheth VN, Stoffel M, De La Vega FM, Friedman JM, Breslow JL, Pe'er I. Low-pass genome-wide sequencing and variant inference using identity-by-descent in an isolated human population. Genetics. 2012 Feb; 190(2):679-89. PMID: 22135348.
    Citations: 18     Fields:    Translation:Humans
  2. Ribeiro AC, Ceccarini G, Dupré C, Friedman JM, Pfaff DW, Mark AL. Contrasting effects of leptin on food anticipatory and total locomotor activity. PLoS One. 2011; 6(8):e23364. PMID: 21853117.
    Citations: 33     Fields:    Translation:Animals
  3. Gusev A, Kenny EE, Lowe JK, Salit J, Saxena R, Kathiresan S, Altshuler DM, Friedman JM, Breslow JL, Pe'er I. DASH: a method for identical-by-descent haplotype mapping uncovers association with recent variation. Am J Hum Genet. 2011 Jun 10; 88(6):706-717. PMID: 21620352.
    Citations: 51     Fields:    Translation:Humans
  4. Donato J, Cravo RM, Frazão R, Gautron L, Scott MM, Lachey J, Castro IA, Margatho LO, Lee S, Lee C, Richardson JA, Friedman J, Chua S, Coppari R, Zigman JM, Elmquist JK, Elias CF. Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons. J Clin Invest. 2011 Jan; 121(1):355-68. PMID: 21183787; PMCID: PMC3007164.
    Citations: 116     Fields:    Translation:HumansAnimalsCells
  5. Kenny EE, Kim M, Gusev A, Lowe JK, Salit J, Smith JG, Kovvali S, Kang HM, Newton-Cheh C, Daly MJ, Stoffel M, Altshuler DM, Friedman JM, Eskin E, Breslow JL, Pe'er I. Increased power of mixed models facilitates association mapping of 10 loci for metabolic traits in an isolated population. Hum Mol Genet. 2011 Feb 15; 20(4):827-39. PMID: 21118897.
    Citations: 15     Fields:    Translation:Humans
  6. Gautron L, Lee C, Funahashi H, Friedman J, Lee S, Elmquist J. Melanocortin-4 receptor expression in a vago-vagal circuitry involved in postprandial functions. J Comp Neurol. 2010 Jan 01; 518(1):6-24. PMID: 19882715.
    Citations: 41     Fields:    Translation:Animals
  7. Alon T, Zhou L, Pérez CA, Garfield AS, Friedman JM, Heisler LK. Transgenic mice expressing green fluorescent protein under the control of the corticotropin-releasing hormone promoter. Endocrinology. 2009 Dec; 150(12):5626-32. PMID: 19854866; PMCID: PMC2795705.
    Citations: 33     Fields:    Translation:AnimalsCells
  8. Bonnen PE, Lowe JK, Altshuler DM, Breslow JL, Stoffel M, Friedman JM, Pe'er I. European admixture on the Micronesian island of Kosrae: lessons from complete genetic information. Eur J Hum Genet. 2010 Mar; 18(3):309-16. PMID: 19844264.
    Citations: 4     Fields:    Translation:HumansCells
  9. Kenny EE, Gusev A, Riegel K, Lütjohann D, Lowe JK, Salit J, Maller JB, Stoffel M, Daly MJ, Altshuler DM, Friedman JM, Breslow JL, Pe'er I, Sehayek E. Systematic haplotype analysis resolves a complex plasma plant sterol locus on the Micronesian Island of Kosrae. Proc Natl Acad Sci U S A. 2009 Aug 18; 106(33):13886-91. PMID: 19667188.
    Citations: 16     Fields:    Translation:Humans
  10. Scott MM, Lachey JL, Sternson SM, Lee CE, Elias CF, Friedman JM, Elmquist JK. Leptin targets in the mouse brain. J Comp Neurol. 2009 Jun 10; 514(5):518-32. PMID: 19350671.
    Citations: 238     Fields:    Translation:Animals
  11. Smith JG, Lowe JK, Kovvali S, Maller JB, Salit J, Daly MJ, Stoffel M, Altshuler DM, Friedman JM, Breslow JL, Newton-Cheh C. Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae. Heart Rhythm. 2009 May; 6(5):634-41. PMID: 19389651.
    Citations: 35     Fields:    Translation:Humans
  12. Lowe JK, Maller JB, Pe'er I, Neale BM, Salit J, Kenny EE, Shea JL, Burkhardt R, Smith JG, Ji W, Noel M, Foo JN, Blundell ML, Skilling V, Garcia L, Sullivan ML, Lee HE, Labek A, Ferdowsian H, Auerbach SB, Lifton RP, Newton-Cheh C, Breslow JL, Stoffel M, Daly MJ, Altshuler DM, Friedman JM. Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. PLoS Genet. 2009 Feb; 5(2):e1000365. PMID: 19197348.
    Citations: 54     Fields:    Translation:Humans
  13. Gusev A, Lowe JK, Stoffel M, Daly MJ, Altshuler D, Breslow JL, Friedman JM, Pe'er I. Whole population, genome-wide mapping of hidden relatedness. Genome Res. 2009 Feb; 19(2):318-26. PMID: 18971310; PMCID: PMC2652213.
    Citations: 218     Fields:    Translation:Humans
  14. Burkhardt R, Kenny EE, Lowe JK, Birkeland A, Josowitz R, Noel M, Salit J, Maller JB, Pe'er I, Daly MJ, Altshuler D, Stoffel M, Friedman JM, Breslow JL. Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13. Arterioscler Thromb Vasc Biol. 2008 Nov; 28(11):2078-84. PMID: 18802019; PMCID: PMC2764366.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  15. Coppola A, Liu ZW, Andrews ZB, Paradis E, Roy MC, Friedman JM, Ricquier D, Richard D, Horvath TL, Gao XB, Diano S. A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2. Cell Metab. 2007 Jan; 5(1):21-33. PMID: 17189204; PMCID: PMC1783766.
    Citations: 117     Fields:    Translation:AnimalsCells
  16. Heisler LK, Jobst EE, Sutton GM, Zhou L, Borok E, Thornton-Jones Z, Liu HY, Zigman JM, Balthasar N, Kishi T, Lee CE, Aschkenasi CJ, Zhang CY, Yu J, Boss O, Mountjoy KG, Clifton PG, Lowell BB, Friedman JM, Horvath T, Butler AA, Elmquist JK, Cowley MA. Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron. 2006 Jul 20; 51(2):239-49. PMID: 16846858.
    Citations: 141     Fields:    Translation:AnimalsCells
  17. Shmulewitz D, Heath SC, Blundell ML, Han Z, Sharma R, Salit J, Auerbach SB, Signorini S, Breslow JL, Stoffel M, Friedman JM. Linkage analysis of quantitative traits for obesity, diabetes, hypertension, and dyslipidemia on the island of Kosrae, Federated States of Micronesia. Proc Natl Acad Sci U S A. 2006 Mar 07; 103(10):3502-9. PMID: 16537441; PMCID: PMC1533774.
    Citations: 30     Fields:    Translation:HumansCells
  18. Bonnen PE, Pe'er I, Plenge RM, Salit J, Lowe JK, Shapero MH, Lifton RP, Breslow JL, Daly MJ, Reich DE, Jones KW, Stoffel M, Altshuler D, Friedman JM. Evaluating potential for whole-genome studies in Kosrae, an isolated population in Micronesia. Nat Genet. 2006 Feb; 38(2):214-7. PMID: 16429162.
    Citations: 39     Fields:    Translation:Humans
  19. Alon T, Friedman JM. Late-onset leanness in mice with targeted ablation of melanin concentrating hormone neurons. J Neurosci. 2006 Jan 11; 26(2):389-97. PMID: 16407534; PMCID: PMC6674397.
    Citations: 51     Fields:    Translation:AnimalsCells
  20. Sternson SM, Shepherd GM, Friedman JM. Topographic mapping of VMH --> arcuate nucleus microcircuits and their reorganization by fasting. Nat Neurosci. 2005 Oct; 8(10):1356-63. PMID: 16172601.
    Citations: 134     Fields:    Translation:AnimalsCells
  21. Segal JP, Stallings NR, Lee CE, Zhao L, Socci N, Viale A, Harris TM, Soares MB, Childs G, Elmquist JK, Parker KL, Friedman JM. Use of laser-capture microdissection for the identification of marker genes for the ventromedial hypothalamic nucleus. J Neurosci. 2005 Apr 20; 25(16):4181-8. PMID: 15843621; PMCID: PMC6724958.
    Citations: 45     Fields:    Translation:Animals
  22. Kishi T, Aschkenasi CJ, Choi BJ, Lopez ME, Lee CE, Liu H, Hollenberg AN, Friedman JM, Elmquist JK. Neuropeptide Y Y1 receptor mRNA in rodent brain: distribution and colocalization with melanocortin-4 receptor. J Comp Neurol. 2005 Feb 14; 482(3):217-43. PMID: 15690487.
    Citations: 38     Fields:    Translation:Animals
  23. Wolfrum C, Asilmaz E, Luca E, Friedman JM, Stoffel M. Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes. Nature. 2004 Dec 23; 432(7020):1027-32. PMID: 15616563.
    Citations: 153     Fields:    Translation:HumansAnimalsCells
  24. Sehayek E, Yu HJ, von Bergmann K, Lutjohann D, Stoffel M, Duncan EM, Garcia-Naveda L, Salit J, Blundell ML, Friedman JM, Breslow JL. Phytosterolemia on the island of Kosrae: founder effect for a novel ABCG8 mutation results in high carrier rate and increased plasma plant sterol levels. J Lipid Res. 2004 Sep; 45(9):1608-13. PMID: 15210841.
    Citations: 7     Fields:    Translation:Humans
  25. Pinto S, Roseberry AG, Liu H, Diano S, Shanabrough M, Cai X, Friedman JM, Horvath TL. Rapid rewiring of arcuate nucleus feeding circuits by leptin. Science. 2004 Apr 02; 304(5667):110-5. PMID: 15064421.
    Citations: 384     Fields:    Translation:AnimalsCells
  26. Roseberry AG, Liu H, Jackson AC, Cai X, Friedman JM. Neuropeptide Y-mediated inhibition of proopiomelanocortin neurons in the arcuate nucleus shows enhanced desensitization in ob/ob mice. Neuron. 2004 Mar 04; 41(5):711-22. PMID: 15003171.
    Citations: 66     Fields:    Translation:AnimalsCells
  27. Haqq AM, René P, Kishi T, Khong K, Lee CE, Liu H, Friedman JM, Elmquist JK, Cone RD. Characterization of a novel binding partner of the melanocortin-4 receptor: attractin-like protein. Biochem J. 2003 Dec 15; 376(Pt 3):595-605. PMID: 14531729; PMCID: PMC1223823.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  28. Ishii M, Fei H, Friedman JM. Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity. Proc Natl Acad Sci U S A. 2003 Sep 02; 100(18):10540-5. PMID: 12925742; PMCID: PMC193597.
    Citations: 31     Fields:    Translation:Animals
  29. Liu H, Kishi T, Roseberry AG, Cai X, Lee CE, Montez JM, Friedman JM, Elmquist JK. Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter. J Neurosci. 2003 Aug 06; 23(18):7143-54. PMID: 12904474; PMCID: PMC6740648.
    Citations: 184     Fields:    Translation:AnimalsCells
  30. Cowley MA, Smith RG, Diano S, Tschöp M, Pronchuk N, Grove KL, Strasburger CJ, Bidlingmaier M, Esterman M, Heiman ML, Garcia-Segura LM, Nillni EA, Mendez P, Low MJ, Sotonyi P, Friedman JM, Liu H, Pinto S, Colmers WF, Cone RD, Horvath TL. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron. 2003 Feb 20; 37(4):649-61. PMID: 12597862.
    Citations: 482     Fields:    Translation:AnimalsCells
  31. Cohen P, Miyazaki M, Socci ND, Hagge-Greenberg A, Liedtke W, Soukas AA, Sharma R, Hudgins LC, Ntambi JM, Friedman JM. Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science. 2002 Jul 12; 297(5579):240-3. PMID: 12114623.
    Citations: 237     Fields:    Translation:AnimalsCells
  32. Han Z, Heath SC, Shmulewitz D, Li W, Auerbach SB, Blundell ML, Lehner T, Ott J, Stoffel M, Friedman JM, Breslow JL. Candidate genes involved in cardiovascular risk factors by a family-based association study on the island of Kosrae, Federated States of Micronesia. Am J Med Genet. 2002 Jul 01; 110(3):234-42. PMID: 12116231.
    Citations: 11     Fields:    Translation:HumansCells
  33. DeFalco J, Tomishima M, Liu H, Zhao C, Cai X, Marth JD, Enquist L, Friedman JM. Virus-assisted mapping of neural inputs to a feeding center in the hypothalamus. Science. 2001 Mar 30; 291(5513):2608-13. PMID: 11283374.
    Citations: 173     Fields:    Translation:AnimalsCells
  34. Shmulewitz D, Auerbach SB, Lehner T, Blundell ML, Winick JD, Youngman LD, Skilling V, Heath SC, Ott J, Stoffel M, Breslow JL, Friedman JM. Epidemiology and factor analysis of obesity, type II diabetes, hypertension, and dyslipidemia (syndrome X) on the Island of Kosrae, Federated States of Micronesia. Hum Hered. 2001; 51(1-2):8-19. PMID: 11096265.
    Citations: 19     Fields:    Translation:Humans
  35. Lin AE, Birch PH, Korf BR, Tenconi R, Niimura M, Poyhonen M, Armfield Uhas K, Sigorini M, Virdis R, Romano C, Bonioli E, Wolkenstein P, Pivnick EK, Lawrence M, Friedman JM. Cardiovascular malformations and other cardiovascular abnormalities in neurofibromatosis 1. Am J Med Genet. 2000 Nov 13; 95(2):108-17. PMID: 11078559.
    Citations: 64     Fields:    Translation:Humans
  36. Weinstock PH, Levak-Frank S, Hudgins LC, Radner H, Friedman JM, Zechner R, Breslow JL. Lipoprotein lipase controls fatty acid entry into adipose tissue, but fat mass is preserved by endogenous synthesis in mice deficient in adipose tissue lipoprotein lipase. Proc Natl Acad Sci U S A. 1997 Sep 16; 94(19):10261-6. PMID: 9294198; PMCID: PMC23350.
    Citations: 63     Fields:    Translation:Animals
  37. Royer WE, Pardanani A, Gibson QH, Peterson ES, Friedman JM. Ordered water molecules as key allosteric mediators in a cooperative dimeric hemoglobin. Proc Natl Acad Sci U S A. 1996 Dec 10; 93(25):14526-31. PMID: 8962085; PMCID: PMC26166.
    Citations: 44     Fields:    Translation:AnimalsCells
  38. Vaisse C, Halaas JL, Horvath CM, Darnell JE, Stoffel M, Friedman JM. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat Genet. 1996 Sep; 14(1):95-7. PMID: 8782827.
    Citations: 290     Fields:    Translation:AnimalsCells
  39. Winick JD, Stoffel M, Friedman JM. Identification of microsatellite markers linked to the human leptin receptor gene on chromosome 1. Genomics. 1996 Aug 15; 36(1):221-2. PMID: 8812446.
    Citations: 9     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.