Harvard Catalyst Profiles

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Sahar Nissim, M.D., Ph.D.

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AGA Caroline Craig Augustyn and Damian Augustyn Award in Digestive Cancer
ASCI Young Physician-Scientist Award
Ken and Louise Goldberg Junior Faculty Award
Burroughs Wellcome Fund Career Award for Medical Scientists
Harvard Digestive Diseases Center Pilot & Feasibility Award
Brigham and Women's Hospital Research Excellence Award, Biomedical Research Institute
National Pancreas Foundation Award
Fellowship2Leadership Salix Fellows' Program
Roger Bigelow Merriman Prize
Phi Beta Kappa, Harvard Junior-24
1994 - 1996
John Harvard Scholar Award
Detur Book Prize
Math and Science Award
American Chemistry Society Award
Pennsylvania Academy of Science Award


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R03DK122232 (NISSIM, SAHAR) Aug 1, 2019 - May 31, 2021
    The Impacts of NR5A2 Pharmacologic Agonism on Pancreas Development and Disease
    Role: Principal Investigator
  2. K08DK105326 (NISSIM, SAHAR) Sep 1, 2015 - Jul 31, 2021
    The Role of NR5A2 in Pancreas Development and Disease
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Das AS, Sherry EC, Vaughan RM, Henderson ML, Zieba J, Uhl KL, Koehn O, Bupp CP, Rajasekaran S, Li X, Chhetri SB, Nissim S, Williams CL, Prokop JW. The complex, dynamic SpliceOme of the small GTPase transcripts altered by technique, sex, genetics, tissue specificity, and RNA base editing. Front Cell Dev Biol. 2022; 10:1033695. PMID: 36467401; PMCID: PMC9714508.
  2. Chittenden A, Haraldsdottir S, Chen E, Nissim S. Germline Testing for Individuals with Pancreatic Adenocarcinoma and Novel Genetic Risk Factors. Hematol Oncol Clin North Am. 2022 10; 36(5):943-960. PMID: 36265992.
    Citations:    Fields:    Translation:HumansCells
  3. Aney KJ, Nissim S. More than acinar identity? A novel cystic phenotype suggests broader roles for NR5A2 in pancreatic cancer†. J Pathol. 2021 05; 254(1):1-4. PMID: 33448017.
    Citations:    Fields:    Translation:AnimalsCells
  4. Nissim S, Leshchiner I, Mancias JD, Greenblatt MB, Maertens O, Cassa CA, Rosenfeld JA, Cox AG, Hedgepeth J, Wucherpfennig JI, Kim AJ, Henderson JE, Gonyo P, Brandt A, Lorimer E, Unger B, Prokop JW, Heidel JR, Wang XX, Ukaegbu CI, Jennings BC, Paulo JA, Gableske S, Fierke CA, Getz G, Sunyaev SR, Wade Harper J, Cichowski K, Kimmelman AC, Houvras Y, Syngal S, Williams C, Goessling W. Mutations in RABL3 alter KRAS prenylation and are associated with hereditary pancreatic cancer. Nat Genet. 2019 09; 51(9):1308-1314. PMID: 31406347; PMCID: PMC7159804.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  5. Cox AG, Tsomides A, Kim AJ, Saunders D, Hwang KL, Evason KJ, Heidel J, Brown KK, Yuan M, Lien EC, Lee BC, Nissim S, Dickinson B, Chhangawala S, Chang CJ, Asara JM, Houvras Y, Gladyshev VN, Goessling W. Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis. Proc Natl Acad Sci U S A. 2016 09 20; 113(38):E5562-71. PMID: 27588899; PMCID: PMC5035897.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  6. Nissim S, Weeks O, Talbot JC, Hedgepeth JW, Wucherpfennig J, Schatzman-Bone S, Swinburne I, Cortes M, Alexa K, Megason S, North TE, Amacher SL, Goessling W. Iterative use of nuclear receptor Nr5a2 regulates multiple stages of liver and pancreas development. Dev Biol. 2016 10 01; 418(1):108-123. PMID: 27474396; PMCID: PMC5100814.
    Citations: 9     Fields:    Translation:AnimalsCells
  7. Cox AG, Hwang KL, Brown KK, Evason K, Beltz S, Tsomides A, O'Connor K, Galli GG, Yimlamai D, Chhangawala S, Yuan M, Lien EC, Wucherpfennig J, Nissim S, Minami A, Cohen DE, Camargo FD, Asara JM, Houvras Y, Stainier DYR, Goessling W. Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth. Nat Cell Biol. 2016 08; 18(8):886-896. PMID: 27428308; PMCID: PMC4990146.
    Citations: 76     Fields:    Translation:HumansAnimals
  8. Mancias JD, Pontano Vaites L, Nissim S, Biancur DE, Kim AJ, Wang X, Liu Y, Goessling W, Kimmelman AC, Harper JW. Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis. Elife. 2015 Oct 05; 4. PMID: 26436293; PMCID: PMC4592949.
    Citations: 118     Fields:    Translation:HumansAnimalsCells
  9. Esain V, Kwan W, Carroll KJ, Cortes M, Liu SY, Frechette GM, Sheward LM, Nissim S, Goessling W, North TE. Cannabinoid Receptor-2 Regulates Embryonic Hematopoietic Stem Cell Development via Prostaglandin E2 and P-Selectin Activity. Stem Cells. 2015 Aug; 33(8):2596-612. PMID: 25931248.
    Citations: 12     Fields:    Translation:AnimalsCells
  10. Carroll KJ, Esain V, Garnaas MK, Cortes M, Dovey MC, Nissim S, Frechette GM, Liu SY, Kwan W, Cutting CC, Harris JM, Gorelick DA, Halpern ME, Lawson ND, Goessling W, North TE. Estrogen defines the dorsal-ventral limit of VEGF regulation to specify the location of the hemogenic endothelial niche. Dev Cell. 2014 May 27; 29(4):437-53. PMID: 24871948.
    Citations: 19     Fields:    Translation:AnimalsCells
  11. Nissim S, Sherwood RI, Wucherpfennig J, Saunders D, Harris JM, Esain V, Carroll KJ, Frechette GM, Kim AJ, Hwang KL, Cutting CC, Elledge S, North TE, Goessling W. Prostaglandin E2 regulates liver versus pancreas cell-fate decisions and endodermal outgrowth. Dev Cell. 2014 Feb 24; 28(4):423-37. PMID: 24530296.
    Citations: 21     Fields:    Translation:AnimalsCells
  12. Nissim S, Idos GE, Wu B. Genetic markers of malignant transformation in intraductal papillary mucinous neoplasm of the pancreas: a meta-analysis. Pancreas. 2012 Nov; 41(8):1195-205. PMID: 22750975.
    Citations: 19     Fields:    Translation:Humans
  13. Scherz PJ, McGlinn E, Nissim S, Tabin CJ. Extended exposure to Sonic hedgehog is required for patterning the posterior digits of the vertebrate limb. Dev Biol. 2007 Aug 15; 308(2):343-54. PMID: 17610861; PMCID: PMC2100419.
    Citations: 61     Fields:    Translation:AnimalsCells
  14. Nissim S, Allard P, Bandyopadhyay A, Harfe BD, Tabin CJ. Characterization of a novel ectodermal signaling center regulating Tbx2 and Shh in the vertebrate limb. Dev Biol. 2007 Apr 01; 304(1):9-21. PMID: 17300775; PMCID: PMC1868507.
    Citations: 27     Fields:    Translation:AnimalsCells
  15. Nissim S, Hasso SM, Fallon JF, Tabin CJ. Regulation of Gremlin expression in the posterior limb bud. Dev Biol. 2006 Nov 01; 299(1):12-21. PMID: 16989805.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  16. Dentice M, Bandyopadhyay A, Gereben B, Callebaut I, Christoffolete MA, Kim BW, Nissim S, Mornon JP, Zavacki AM, Zeöld A, Capelo LP, Curcio-Morelli C, Ribeiro R, Harney JW, Tabin CJ, Bianco AC. The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate. Nat Cell Biol. 2005 Jul; 7(7):698-705. PMID: 15965468; PMCID: PMC1761694.
    Citations: 102     Fields:    Translation:HumansAnimalsCells
  17. Nissim S. Signaling Centers in Early Limb Development. 2005.
  18. Harfe BD, Scherz PJ, Nissim S, Tian H, McMahon AP, Tabin CJ. Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell. 2004 Aug 20; 118(4):517-28. PMID: 15315763.
    Citations: 468     Fields:    Translation:AnimalsCells
  19. Nissim S, Tabin C. A novel ectodermal signaling center regulating Tbx2 in the Vertebrate Limb. 2004.
  20. Rallis C, Bruneau BG, Del Buono J, Seidman CE, Seidman JG, Nissim S, Tabin CJ, Logan MP. Tbx5 is required for forelimb bud formation and continued outgrowth. Development. 2003 Jun; 130(12):2741-51. PMID: 12736217.
    Citations: 82     Fields:    Translation:AnimalsCells
  21. Nissim S, Tabin C. Development of the Limbs. Inborn Errors of Development. 2003.
  22. Park KI, Lachyankar M, Nissim S, Snyder EY. Neural stem cells for CNS repair: state of the art and future directions. Adv Exp Med Biol. 2002; 506(Pt B):1291-6. PMID: 12614070.
    Citations: 7     Fields:    Translation:Humans
  23. Harpavat S, Nissim S. Microcards. 2001.
  24. Park KI, Liu S, Flax JD, Nissim S, Stieg PE, Snyder EY. Transplantation of neural progenitor and stem cells: developmental insights may suggest new therapies for spinal cord and other CNS dysfunction. J Neurotrauma. 1999 Aug; 16(8):675-87. PMID: 10511240.
    Citations: 18     Fields:    Translation:AnimalsCells
  25. Nissim S, Snyder EY. The Role of Membrane Factors in Influencing the Neuronal Differentiation of C17-2 Neural Stem Cells. Society for Neuroscience Abstracts. 1998.
  26. Nissim S, Weng-Keong T. Chimeric Receptors with Antibody-Type Specificity: Design and Functional Analysis. 24th Dr. Bessie F. Lawrence Institute Scientific Research Journal. 1993.
  27. Nissim S. Regulation of Gene Expression. Book of Abstracts. 1993.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.