Harvard Catalyst Profiles

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Rebecca Marlene Baron, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01GM115605 (FEINBERG, MARK W) Aug 15, 2015 - May 31, 2019
    NIH/NIGMS
    MicroRNA-181b and Sepsis
    Role: Principal Investigator
  2. R01HL112747 (BARON, REBECCA M) May 15, 2012 - Apr 30, 2016
    NIH/NHLBI
    The Inflammasome: A Novel Biomarker in ALI/ARDS
    Role: Principal Investigator
  3. P01HL108801 (PERRELLA, MARK A) Aug 15, 2011 - Jun 30, 2016
    NIH/NHLBI
    Carbon Monoxide: Novel Opportunities for Therapy
    Role: Co-Principal Investigator
  4. R01HL091957 (BARON, REBECCA M) Apr 1, 2009 - Jan 31, 2015
    NIH/NHLBI
    Role of NOS2 in Sepsis-Induced ARDS
    Role: Principal Investigator
  5. K08AI054465 (BARON, REBECCA M) May 1, 2003 - Apr 30, 2009
    NIH/NIAID
    HMG-1/Y Regulation of NOS2 Expression in Endotoxemia
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Englert JA, Bobba C, Baron RM. Integrating molecular pathogenesis and clinical translation in sepsis-induced acute respiratory distress syndrome. JCI Insight. 2019 Jan 24; 4(2). PMID: 30674720.
    Citations:    Fields:    
  2. Englert JA, Cho MH, Lamb AE, Shumyatcher M, Barragan-Bradford D, Basil MC, Higuera A, Isabelle C, Vera MP, Dieffenbach PB, Fredenburgh LE, Kang JB, Bhatt AS, Antin JH, Ho VT, Soiffer RJ, Howrylak JA, Himes BE, Baron RM. Whole blood RNA sequencing reveals a unique transcriptomic profile in patients with ARDS following hematopoietic stem cell transplantation. Respir Res. 2019 Jan 21; 20(1):15. PMID: 30665420.
    Citations:    Fields:    
  3. Johansson PI, Nakahira K, Rogers AJ, McGeachie MJ, Baron RM, Fredenburgh LE, Harrington J, Choi AMK, Christopher KB. Plasma mitochondrial DNA and metabolomic alterations in severe critical illness. Crit Care. 2018 12 29; 22(1):360. PMID: 30594224.
    Citations:    Fields:    
  4. Fredenburgh LE, Perrella MA, Barragan-Bradford D, Hess DR, Peters E, Welty-Wolf KE, Kraft BD, Harris RS, Maurer R, Nakahira K, Oromendia C, Davies JD, Higuera A, Schiffer KT, Englert JA, Dieffenbach PB, Berlin DA, Lagambina S, Bouthot M, Sullivan AI, Nuccio PF, Kone MT, Malik MJ, Porras MAP, Finkelsztein E, Winkler T, Hurwitz S, Serhan CN, Piantadosi CA, Baron RM, Thompson BT, Choi AM. A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS. JCI Insight. 2018 Dec 06; 3(23). PMID: 30518685.
    Citations:    Fields:    
  5. Williams CS, Iness AN, Baron RM, Ajijola OA, Hu PJ, Vyas JM, Baiocchi R, Adami AJ, Lever JM, Klein PS, Demer L, Madaio M, Geraci M, Brass LF, Blanchard M, Salata R, Zaidi M. Training the physician-scientist: views from program directors and aspiring young investigators. JCI Insight. 2018 Dec 06; 3(23). PMID: 30518696.
    Citations:    Fields:    
  6. Rogers AJ, Solus JF, Hunninghake GM, Baron RM, Meyer NJ, Janz DR, Schwartz DA, May AK, Lawson WE, Blackwell TS, Ware LB. MUC5B Promoter Polymorphism and Development of Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2018 Nov 15; 198(10):1342-1345. PMID: 30025215.
    Citations:    Fields:    
  7. Motta-Ribeiro GC, Hashimoto S, Winkler T, Baron RM, Grogg K, Paula LFSC, Santos A, Zeng C, Hibbert K, Harris RS, Bajwa E, Vidal Melo MF. Deterioration of Regional Lung Strain and Inflammation during Early Lung Injury. Am J Respir Crit Care Med. 2018 Oct 01; 198(7):891-902. PMID: 29787304.
    Citations:    Fields:    
  8. Hume PS, Varon J, Englert JA, Hurwitz S, Klompas M, Baron RM, Rhee C. Trends in "usual care" for septic shock. Infect Control Hosp Epidemiol. 2018 Sep; 39(9):1125-1126. PMID: 30022742.
    Citations:    Fields:    
  9. Ma KC, Schenck EJ, Siempos II, Cloonan SM, Finkelzstein EJ, Pabon MA, Oromendia C, Ballman KV, Baron RM, Fredenburgh LE, Higuera A, Lee JY, Chung CR, Jeon K, Yang JH, Howrylak JA, Huh JW, Suh GY, Choi AM. Circulating RIPK3 levels are associated with mortality and organ failure during critical illness. JCI Insight. 2018 Jul 12; 3(13). PMID: 29997296.
    Citations:    Fields:    
  10. Baron RM, Kwon MY, Castano AP, Ghanta S, Riascos-Bernal DF, Lopez-Guzman S, Macias AA, Ith B, Schissel SL, Lederer JA, Reeves R, Yet SF, Layne MD, Liu X, Perrella MA. Frontline Science: Targeted expression of a dominant-negative high mobility group A1 transgene improves outcome in sepsis. J Leukoc Biol. 2018 Oct; 104(4):677-689. PMID: 29975792.
    Citations:    Fields:    
  11. Siempos II, Ma KC, Imamura M, Baron RM, Fredenburgh LE, Huh JW, Moon JS, Finkelsztein EJ, Jones DS, Lizardi MT, Schenck EJ, Ryter SW, Nakahira K, Choi AM. RIPK3 mediates pathogenesis of experimental ventilator-induced lung injury. JCI Insight. 2018 May 03; 3(9). PMID: 29720570.
    Citations: 1     Fields:    
  12. Abdulnour RE, Howrylak JA, Tavares AH, Douda DN, Henkels KM, Miller TE, Fredenburgh LE, Baron RM, Gomez-Cambronero J, Levy BD. Phospholipase D isoforms differentially regulate leukocyte responses to acute lung injury. J Leukoc Biol. 2018 May; 103(5):919-932. PMID: 29437245.
    Citations:    Fields:    
  13. Park J, Pabon M, Choi AMK, Siempos II, Fredenburgh LE, Baron RM, Jeon K, Chung CR, Yang JH, Park CM, Suh GY. Plasma surfactant protein-D as a diagnostic biomarker for acute respiratory distress syndrome: validation in US and Korean cohorts. BMC Pulm Med. 2017 Dec 15; 17(1):204. PMID: 29246207.
    Citations: 1     Fields:    Translation:Humans
  14. Baron BW, Baron RM, Baron JM. Reticulocytes Are an Enriched Source of the RUVBL1 Protein. Acta Haematol. 2017; 138(3):162-165. PMID: 28982102.
    Citations:    Fields:    Translation:HumansCells
  15. Santacruz L, Arciniegas AJL, Darrabie M, Mantilla JG, Baron RM, Bowles DE, Mishra R, Jacobs DO. Hypoxia decreases creatine uptake in cardiomyocytes, while creatine supplementation enhances HIF activation. Physiol Rep. 2017 Aug; 5(16). PMID: 28821596.
    Citations: 1     Fields:    Translation:AnimalsCells
  16. Lasky-Su J, Dahlin A, Litonjua AA, Rogers AJ, McGeachie MJ, Baron RM, Gazourian L, Barragan-Bradford D, Fredenburgh LE, Choi AMK, Mogensen KM, Quraishi SA, Amrein K, Christopher KB. Metabolome alterations in severe critical illness and vitamin D status. Crit Care. 2017 07 28; 21(1):193. PMID: 28750641.
    Citations: 1     Fields:    Translation:Humans
  17. Boudreault F, Pinilla-Vera M, Englert JA, Kho AT, Isabelle C, Arciniegas AJ, Barragan-Bradford D, Quintana C, Amador-Munoz D, Guan J, Choi KM, Sholl L, Hurwitz S, Tschumperlin DJ, Baron RM. Zinc deficiency primes the lung for ventilator-induced injury. JCI Insight. 2017 Jun 02; 2(11). PMID: 28570269.
    Citations:    Fields:    
  18. Dalli J, Colas RA, Quintana C, Barragan-Bradford D, Hurwitz S, Levy BD, Choi AM, Serhan CN, Baron RM. Human Sepsis Eicosanoid and Proresolving Lipid Mediator Temporal Profiles: Correlations With Survival and Clinical Outcomes. Crit Care Med. 2017 Jan; 45(1):58-68. PMID: 27632672.
    Citations: 26     Fields:    Translation:Humans
  19. Putman RK, Hunninghake GM, Dieffenbach PB, Barragan-Bradford D, Serhan K, Adams U, Hatabu H, Nishino M, Padera RF, Fredenburgh LE, Baron RM, Englert JA. Interstitial Lung Abnormalities Are Associated with Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2017 01 01; 195(1):138-141. PMID: 28035861.
    Citations:    Fields:    Translation:Humans
  20. Tsoyi K, Hall SR, Dalli J, Colas RA, Ghanta S, Ith B, Coronata A, Fredenburgh LE, Baron RM, Choi AM, Serhan CN, Liu X, Perrella MA. Carbon Monoxide Improves Efficacy of Mesenchymal Stromal Cells During Sepsis by Production of Specialized Proresolving Lipid Mediators. Crit Care Med. 2016 Dec; 44(12):e1236-e1245. PMID: 27513357.
    Citations: 10     Fields:    Translation:Animals
  21. Hepokoski M, Englert JA, Baron RM, Crotty-Alexander LE, Fuster MM, Beitler JR, Malhotra A, Singh P. Ventilator-induced lung injury increases expression of endothelial inflammatory mediators in the kidney. Am J Physiol Renal Physiol. 2017 04 01; 312(4):F654-F660. PMID: 28365585.
    Citations: 3     Fields:    Translation:AnimalsCells
  22. Wellman TJ, de Prost N, Tucci M, Winkler T, Baron RM, Filipczak P, Raby B, Chu JH, Harris RS, Musch G, Dos Reis Falcao LF, Capelozzi V, Venegas JG, Vidal Melo MF. Lung Metabolic Activation as an Early Biomarker of Acute Respiratory Distress Syndrome and Local Gene Expression Heterogeneity. Anesthesiology. 2016 11; 125(5):992-1004. PMID: 27611185.
    Citations: 2     Fields:    Translation:Animals
  23. Prieto JL, Su HW, Hou HW, Vera MP, Levy BD, Baron RM, Han J, Voldman J. Monitoring sepsis using electrical cell profiling. Lab Chip. 2016 11 01; 16(22):4333-4340. PMID: 27722555.
    Citations: 1     Fields:    Translation:AnimalsCells
  24. Mogensen KM, Lasky-Su J, Rogers AJ, Baron RM, Fredenburgh LE, Rawn J, Robinson MK, Massarro A, Choi AM, Christopher KB. Metabolites Associated With Malnutrition in the Intensive Care Unit Are Also Associated With 28-Day Mortality. JPEN J Parenter Enteral Nutr. 2017 02; 41(2):188-197. PMID: 27406941.
    Citations: 2     Fields:    Translation:Humans
  25. Baron BW, Baron RM, Baron JM. The Relationship between RUVBL1 (Pontin, TIP49, NMP238) and BCL6 in Benign and Malignant Human Lymphoid Tissues. Biochem Biophys Rep. 2016 Jul; 6:1-8. PMID: 27066592.
    Citations: 2     
  26. Kuethe DO, Filipczak PT, Hix JM, Gigliotti AP, Estépar RS, Washko GR, Baron RM, Fredenburgh LE. Magnetic resonance imaging provides sensitive in vivo assessment of experimental ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2016 08 01; 311(2):L208-18. PMID: 27288491.
    Citations: 3     Fields:    Translation:Animals
  27. Baron RM, Levy BD. Recent advances in understanding and treating ARDS. F1000Res. 2016; 5. PMID: 27158460; PMCID: PMC4847560.
    Citations: 8     
  28. Hou HW, Wu L, Amador-Munoz DP, Vera MP, Coronata A, Englert JA, Levy BD, Baron RM, Han J. Broad spectrum immunomodulation using biomimetic blood cell margination for sepsis therapy. Lab Chip. 2016 Feb 21; 16(4):688-99. PMID: 26767950; PMCID: PMC4747785.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  29. Shrime MG, Ferket BS, Scott DJ, Lee J, Barragan-Bradford D, Pollard T, Arabi YM, Al-Dorzi HM, Baron RM, Hunink MG, Celi LA, Lai PS. Time-Limited Trials of Intensive Care for Critically Ill Patients With Cancer: How Long Is Long Enough? JAMA Oncol. 2016 Jan; 2(1):76-83. PMID: 26469222; PMCID: PMC4713248.
    Citations: 5     Fields:    Translation:Humans
  30. Fredenburgh LE, Kraft BD, Hess DR, Harris RS, Wolf MA, Suliman HB, Roggli VL, Davies JD, Winkler T, Stenzler A, Baron RM, Thompson BT, Choi AM, Welty-Wolf KE, Piantadosi CA. Effects of inhaled CO administration on acute lung injury in baboons with pneumococcal pneumonia. Am J Physiol Lung Cell Mol Physiol. 2015 Oct 15; 309(8):L834-46. PMID: 26320156.
    Citations: 6     Fields:    Translation:HumansAnimals
  31. Englert JA, Macias AA, Amador-Munoz D, Pinilla Vera M, Isabelle C, Guan J, Magaoay B, Suarez Velandia M, Coronata A, Lee A, Fredenburgh LE, Culley DJ, Crosby G, Baron RM. Isoflurane Ameliorates Acute Lung Injury by Preserving Epithelial Tight Junction Integrity. Anesthesiology. 2015 Aug; 123(2):377-88. PMID: 26068207; PMCID: PMC4510009.
    Citations: 10     Fields:    Translation:AnimalsCells
  32. Filipczak PT, Senft AP, Seagrave J, Weber W, Kuehl PJ, Fredenburgh LE, McDonald JD, Baron RM. NOS-2 Inhibition in Phosgene-Induced Acute Lung Injury. Toxicol Sci. 2015 Jul; 146(1):89-100. PMID: 25870319; PMCID: PMC4476462.
    Citations: 3     Fields:    Translation:Animals
  33. Baron BW, Baron RM, Baron JM. The ITM2B (BRI2) gene is a target of BCL6 repression: Implications for lymphomas and neurodegenerative diseases. Biochim Biophys Acta. 2015 May; 1852(5):742-8. PMID: 25557390; PMCID: PMC4636210.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  34. Platzer B, Baker K, Vera MP, Singer K, Panduro M, Lexmond WS, Turner D, Vargas SO, Kinet JP, Maurer D, Baron RM, Blumberg RS, Fiebiger E. Dendritic cell-bound IgE functions to restrain allergic inflammation at mucosal sites. Mucosal Immunol. 2015 May; 8(3):516-32. PMID: 25227985; PMCID: PMC4363306.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  35. Langley RJ, Tipper JL, Bruse S, Baron RM, Tsalik EL, Huntley J, Rogers AJ, Jaramillo RJ, O'Donnell D, Mega WM, Keaton M, Kensicki E, Gazourian L, Fredenburgh LE, Massaro AF, Otero RM, Fowler VG, Rivers EP, Woods CW, Kingsmore SF, Sopori ML, Perrella MA, Choi AM, Harrod KS. Integrative "omic" analysis of experimental bacteremia identifies a metabolic signature that distinguishes human sepsis from systemic inflammatory response syndromes. Am J Respir Crit Care Med. 2014 Aug 15; 190(4):445-55. PMID: 25054455; PMCID: PMC4214130.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  36. Khabibullin D, Medvetz DA, Pinilla M, Hariharan V, Li C, Hergrueter A, Laucho Contreras M, Zhang E, Parkhitko A, Yu JJ, Owen CA, Huang H, Baron RM, Henske EP. Folliculin regulates cell-cell adhesion, AMPK, and mTORC1 in a cell-type-specific manner in lung-derived cells. Physiol Rep. 2014 Aug 01; 2(8). PMID: 25121506; PMCID: PMC4246594.
    Citations: 10     Fields:    
  37. Gazourian L, Rogers AJ, Ibanga R, Weinhouse GL, Pinto-Plata V, Ritz J, Soiffer RJ, Antin JH, Washko GR, Baron RM, Ho VT. Factors associated with bronchiolitis obliterans syndrome and chronic graft-versus-host disease after allogeneic hematopoietic cell transplantation. Am J Hematol. 2014 Apr; 89(4):404-9. PMID: 24375545; PMCID: PMC4314109.
    Citations: 5     Fields:    Translation:HumansCells
  38. Rogers AJ, McGeachie M, Baron RM, Gazourian L, Haspel JA, Nakahira K, Fredenburgh LE, Hunninghake GM, Raby BA, Matthay MA, Otero RM, Fowler VG, Rivers EP, Woods CW, Kingsmore S, Langley RJ, Choi AM. Metabolomic derangements are associated with mortality in critically ill adult patients. PLoS One. 2014; 9(1):e87538. PMID: 24498130; PMCID: PMC3907548.
    Citations: 28     Fields:    Translation:Humans
  39. Nakahira K, Kyung SY, Rogers AJ, Gazourian L, Youn S, Massaro AF, Quintana C, Osorio JC, Wang Z, Zhao Y, Lawler LA, Christie JD, Meyer NJ, Mc Causland FR, Waikar SS, Waxman AB, Chung RT, Bueno R, Rosas IO, Fredenburgh LE, Baron RM, Christiani DC, Hunninghake GM, Choi AM. Circulating mitochondrial DNA in patients in the ICU as a marker of mortality: derivation and validation. PLoS Med. 2013 Dec; 10(12):e1001577; discussion e1001577. PMID: 24391478; PMCID: PMC3876981.
    Citations: 75     Fields:    Translation:Humans
  40. Li Y, Dalli J, Chiang N, Baron RM, Quintana C, Serhan CN. Plasticity of leukocytic exudates in resolving acute inflammation is regulated by MicroRNA and proresolving mediators. Immunity. 2013 Nov 14; 39(5):885-98. PMID: 24238341; PMCID: PMC3888517.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  41. Langley RJ, Tsalik EL, van Velkinburgh JC, Glickman SW, Rice BJ, Wang C, Chen B, Carin L, Suarez A, Mohney RP, Freeman DH, Wang M, You J, Wulff J, Thompson JW, Moseley MA, Reisinger S, Edmonds BT, Grinnell B, Nelson DR, Dinwiddie DL, Miller NA, Saunders CJ, Soden SS, Rogers AJ, Gazourian L, Fredenburgh LE, Massaro AF, Baron RM, Choi AM, Corey GR, Ginsburg GS, Cairns CB, Otero RM, Fowler VG, Rivers EP, Woods CW, Kingsmore SF. An integrated clinico-metabolomic model improves prediction of death in sepsis. Sci Transl Med. 2013 Jul 24; 5(195):195ra95. PMID: 23884467; PMCID: PMC3924586.
    Citations: 92     Fields:    Translation:Humans
  42. Lai PS, Hofmann O, Baron RM, Cernadas M, Meng QR, Bresler HS, Brass DM, Yang IV, Schwartz DA, Christiani DC, Hide W. Integrating murine gene expression studies to understand obstructive lung disease due to chronic inhaled endotoxin. PLoS One. 2013; 8(5):e62910. PMID: 23675439; PMCID: PMC3652821.
    Citations:    Fields:    Translation:AnimalsCells
  43. Saha D, Takahashi K, de Prost N, Winkler T, Pinilla-Vera M, Baron RM, Vidal Melo MF. Micro-autoradiographic assessment of cell types contributing to 2-deoxy-2-[(18)F]fluoro-D-glucose uptake during ventilator-induced and endotoxemic lung injury. Mol Imaging Biol. 2013 Feb; 15(1):19-27. PMID: 22752654.
    Citations: 16     Fields:    Translation:AnimalsCells
  44. Gazourian L, Coronata AM, Rogers AJ, Weinhouse GL, Soiffer RJ, Antin JH, Ritz J, Ho VT, Baron RM, Washko GR. Airway dilation in bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation. Respir Med. 2013 Feb; 107(2):276-83. PMID: 23195332; PMCID: PMC3543517.
    Citations: 3     Fields:    Translation:Humans
  45. Manoli SE, Smith LA, Vyhlidal CA, An CH, Porrata Y, Cardoso WV, Baron RM, Haley KJ. Maternal smoking and the retinoid pathway in the developing lung. Respir Res. 2012 Jun 01; 13:42. PMID: 22651576; PMCID: PMC3479035.
    Citations: 9     Fields:    Translation:AnimalsCells
  46. Sun X, Icli B, Wara AK, Belkin N, He S, Kobzik L, Hunninghake GM, Vera MP, Blackwell TS, Baron RM, Feinberg MW. MicroRNA-181b regulates NF-?B-mediated vascular inflammation. J Clin Invest. 2012 Jun; 122(6):1973-90. PMID: 22622040; PMCID: PMC3366408.
    Citations: 144     Fields:    Translation:HumansAnimalsCells
  47. Baron RM. Point: should coagulopathy be repaired prior to central venous line insertion? Yes: why take chances? Chest. 2012 May; 141(5):1139-1142. PMID: 22553259.
    Citations: 4     Fields:    Translation:Humans
  48. Lai PS, Fresco JM, Pinilla MA, Macias AA, Brown RD, Englert JA, Hofmann O, Lederer JA, Hide W, Christiani DC, Cernadas M, Baron RM. Chronic endotoxin exposure produces airflow obstruction and lung dendritic cell expansion. Am J Respir Cell Mol Biol. 2012 Aug; 47(2):209-17. PMID: 22517795; PMCID: PMC3423463.
    Citations: 8     Fields:    Translation:AnimalsCellsPHPublic Health
  49. Dolinay T, Kim YS, Howrylak J, Hunninghake GM, An CH, Fredenburgh L, Massaro AF, Rogers A, Gazourian L, Nakahira K, Haspel JA, Landazury R, Eppanapally S, Christie JD, Meyer NJ, Ware LB, Christiani DC, Ryter SW, Baron RM, Choi AM. Inflammasome-regulated cytokines are critical mediators of acute lung injury. Am J Respir Crit Care Med. 2012 Jun 01; 185(11):1225-34. PMID: 22461369.
    Citations: 102     Fields:    Translation:HumansAnimals
  50. Olszak T, An D, Zeissig S, Vera MP, Richter J, Franke A, Glickman JN, Siebert R, Baron RM, Kasper DL, Blumberg RS. Microbial exposure during early life has persistent effects on natural killer T cell function. Science. 2012 Apr 27; 336(6080):489-93. PMID: 22442383; PMCID: PMC3437652.
    Citations: 397     Fields:    Translation:AnimalsCells
  51. Baron RM, Choi AJ, Owen CA, Choi AM. Genetically manipulated mouse models of lung disease: potential and pitfalls. Am J Physiol Lung Cell Mol Physiol. 2012 Mar 15; 302(6):L485-97. PMID: 22198907; PMCID: PMC4074003.
    Citations: 16     Fields:    Translation:HumansAnimals
  52. Zhou X, Baron RM, Hardin M, Cho MH, Zielinski J, Hawrylkiewicz I, Sliwinski P, Hersh CP, Mancini JD, Lu K, Thibault D, Donahue AL, Klanderman BJ, Rosner B, Raby BA, Lu Q, Geldart AM, Layne MD, Perrella MA, Weiss ST, Choi AM, Silverman EK. Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP. Hum Mol Genet. 2012 Mar 15; 21(6):1325-35. PMID: 22140090.
    Citations: 48     Fields:    Translation:HumansCells
  53. Fredenburgh LE, Velandia MM, Ma J, Olszak T, Cernadas M, Englert JA, Chung SW, Liu X, Begay C, Padera RF, Blumberg RS, Walsh SR, Baron RM, Perrella MA. Cyclooxygenase-2 deficiency leads to intestinal barrier dysfunction and increased mortality during polymicrobial sepsis. J Immunol. 2011 Nov 15; 187(10):5255-67. PMID: 21967897; PMCID: PMC3208135.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  54. Baron RM, Lopez-Guzman S, Riascos DF, Macias AA, Layne MD, Cheng G, Harris C, Chung SW, Reeves R, von Andrian UH, Perrella MA. Distamycin A inhibits HMGA1-binding to the P-selectin promoter and attenuates lung and liver inflammation during murine endotoxemia. PLoS One. 2010 May 14; 5(5):e10656. PMID: 20498830.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  55. Grant MA, Baron RM, Macias AA, Layne MD, Perrella MA, Rigby AC. Netropsin improves survival from endotoxaemia by disrupting HMGA1 binding to the NOS2 promoter. Biochem J. 2009 Feb 15; 418(1):103-12. PMID: 18937643; PMCID: PMC2821790.
    Citations: 8     Fields:    Translation:AnimalsCells
  56. Dolinay T, Baron RM, Fredenburgh L, Massaro AF, Lanazury R, Nakahira K, Choi AMK. Inflammasome Mediators Predict Disease Severity and Mortality in Patients with Sepsis and Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2009; 179:A4646.
  57. JM Austin, JA Englert, RD Brown, B Ith, MA Perrella, DC Christiani, RM Baron. Modeling Physiologic Effects of Chronic Endotoxin Exposure in Mice [Oral presentation]. Am J Respir Crit Care Med. 2009; 179:A2189.
  58. JA Englert, L Dolgonos, DF Riascos, RM Baron. Increased NOS2 Expression in a Clinically-Relevant Murine Model of ARDS [Poster-Discussion] . Am J Respir Crit Care Med. 2009; 179:A3865.
  59. Takamiya R, Hung CC, Hall SR, Fukunaga K, Nagaishi T, Maeno T, Owen C, Macias AA, Fredenburgh LE, Ishizaka A, Blumberg RS, Baron RM, Perrella MA. High-mobility group box 1 contributes to lethality of endotoxemia in heme oxygenase-1-deficient mice. Am J Respir Cell Mol Biol. 2009 Aug; 41(2):129-35. PMID: 19097991; PMCID: PMC2715902.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  60. Takamiya R, Baron RM, Yet SF, Layne MD, Perrella MA. High mobility group A1 protein mediates human nitric oxide synthase 2 gene expression. FEBS Lett. 2008 Mar 05; 582(5):810-4. PMID: 18279675; PMCID: PMC2271050.
    Citations: 4     Fields:    Translation:HumansCells
  61. Baron RM, Perrella MA. Pathogenesis of Acute Lung Injury: Experimental Studies. Acute Respiratory Distress Syndrome, Editor: Augustine Choi. 2008.
  62. Chung SW, Liu X, Macias AA, Baron RM, Perrella MA. Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice. J Clin Invest. 2008 Jan; 118(1):239-47. PMID: 18060048; PMCID: PMC2104480.
    Citations: 88     Fields:    Translation:HumansAnimalsCells
  63. Englert JA, Baron RM. Sepsis Syndrome. Harvard Intensive Review of Internal Medicine. 2008.
  64. Baron RM, Riascos DF, Macias AA, Yet S-F, Layne MD, Perrella MA. Inhibition of HMGA1-DNA Binding in Mouse Vasculature Attenuates NOS2 Induction and Ameliorates Hypotension during Endotoxemia [Oral Presentation] . Proceedings of the American Thoracic Society. 2008.
  65. Baron BW, Zeleznik-Le N, Baron MJ, Theisler C, Huo D, Krasowski MD, Thirman MJ, Baron RM, Baron JM. Repression of the PDCD2 gene by BCL6 and the implications for the pathogenesis of human B and T cell lymphomas. Proc Natl Acad Sci U S A. 2007 May 01; 104(18):7449-54. PMID: 17468402; PMCID: PMC1863460.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  66. Marty FM, Lowry CM, Wilck M, Baron RM, Baden LR. Emergence of a clinical tigecycline-resistant mycobacterium abscessus during treatment of mycobacteremia and empyema after lung transplantation. ICAAC Meeting. 2006.
  67. Baron RM, Baron MJ, Perrella MA. Pathobiology of sepsis: are we still asking the same questions? Am J Respir Cell Mol Biol. 2006 Feb; 34(2):129-34. PMID: 16421210.
    Citations: 10     Fields:    Translation:HumansAnimals
  68. Baron RM, Macias AA, Cheng G, von Andrian UH, Perrella MA. Minor Groove Binding Agents Attenuate Lung Inflammation, Modulate Neutrophil Adhesion, and Improve Outcomes during Murine Endotoxemia [abstract]. Proceedings of the American Thoracic Society. 2006.
  69. Baron RM. Critical Care Medicine. Winshall JS, Lederman RJ, editors. Tarascon Internal Medicine and Critical Care Pocketbook. 2006.
  70. Wang Y, Baron RM, Zhu G, Joo M, Christman JW, Silverman ES, Perrella MA, Riese RJ, Cernadas M. PU.1 regulates cathepsin S expression in professional APCs. J Immunol. 2006 Jan 01; 176(1):275-83. PMID: 16365419.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  71. Baron R, Macias A, Cheng G, Grant M, Rigby A, von Andrian UH, Perrella MA. Interference with AT-Rich DNA Binding Attenuates NOS2 Induction and Improves Outcomes from Murine Endotoxemic Shock [abstract]. 2006 ASCI/AAP Joint Meeting Poster Abstracts. 2006.
  72. Baron RM. Pulmonary Medicine. Winshall JS, Lederman RJ, editors. Tarascon Internal Medicine and Critical Care Pocketbook. 2006.
  73. Fredenburgh LE, Baron RM, Carvajal IM, Mouded M, Macias AA, Ith B, Perrella MA. Absence of heme oxygenase-1 expression in the lung parenchyma exacerbates endotoxin-induced acute lung injury and decreases surfactant protein-B levels. Cell Mol Biol. 2005; 51(5):513-520.
  74. Fredenburgh LE, Baron RM, Carvajal IM, Mouded M, Macias AA, Ith B, Perrella MA. Absence of heme oxygenase-1 expression in the lung parenchyma exacerbates endotoxin-induced acute lung injury and decreases surfactant protein-B levels. Cell Mol Biol (Noisy-le-grand). 2005 Oct 03; 51(5):513-20. PMID: 16309574.
    Citations: 12     Fields:    Translation:Animals
  75. Fredenburgh LE, Ejima K, Baron RM, Chung SW, Layne MD, Perrella MA . Enhanced COX-2 Expression in HO-1 Null Mice Contributes to Endotoxemic Lung Injury [abstract] . Proceedings of the American Thoracic Society. 2005; 2:A152.
  76. Fredenburgh LE, Baron RM, Carvajal IM, Mouded M, Macias AA, Ith B, Perrella MA. Absence of Heme Oxygenase-1 Expression in the Lung Parenchyma Exacerbates Endotoxin-Induced Acute Lung Injury [abstract]. Heme Oxygenase-1 International Conference Proceedings. 2005.
  77. Baron RM, Macias AA, Fredenburgh LE, Okabe RO, Layne MD, Perrella MA. Reduction of Nitric Oxide Synthase-2 Expression by Minor Groove Binding Agents Improves Survival from Endotoxemia [abstract] . Proceedings of the American Thoracic Society. 2005; 2:A930.
  78. Baron BW, Anastasi J, Montag A, Huo D, Baron RM, Karrison T, Thirman MJ, Subudhi SK, Chin RK, Felsher DW, Fu YX, McKeithan TW, Baron JM. The human BCL6 transgene promotes the development of lymphomas in the mouse. Proc Natl Acad Sci U S A. 2004 Sep 28; 101(39):14198-203. PMID: 15375218; PMCID: PMC521136.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  79. Baron RM, Carvajal IM, Liu X, Okabe RO, Fredenburgh LE, Macias AA, Chen YH, Ejima K, Layne MD, Perrella MA. Reduction of nitric oxide synthase 2 expression by distamycin A improves survival from endotoxemia. J Immunol. 2004 Sep 15; 173(6):4147-53. PMID: 15356165.
    Citations: 9     Fields:    Translation:AnimalsCells
  80. Baron RM, Carvajal IM, Fredenburgh LE, Liu X, Porrata Y, Cullivan ML, Haley KJ, Sonna LA, De Sanctis GT, Ingenito EP, Perrella MA. Nitric oxide synthase-2 down-regulates surfactant protein-B expression and enhances endotoxin-induced lung injury in mice. FASEB J. 2004 Aug; 18(11):1276-8. PMID: 15208261.
    Citations: 15     Fields:    Translation:AnimalsCells
  81. Fredenburgh LE, Ejima K, Liu X, Baron RM, Perrella MA. Attenuation of Hypotension in COX-2 Null Mice Contributes to Improved Outcome in Endotoxemia [abstract] . Am J Resp Crit Care Med. 2004; 30:A636.
  82. Baron RM. Pulmonary Medicine. Winshall JS, Lederman RJ, editors. Tarascon Internal Medicine and Critical Care Pocketbook. 2004; 130-140.
  83. Baron RM, Carvajal IM, Fredenburgh LE, Liu X, Porrata Y, Haley KJ, Sonna LA, De Sanctis GT, Ingenito EP, Perrella MA . Nitric Oxide Synthase-2 Mediates Acute Lung Injury in Mice through Decreased Surfactant Protein-B Expression [abstract] . Am J Resp Crit Care Med. 2004; 30:A264.
  84. Baron RM. Critical Care Medicine. Winshall JS, Lederman RJ, editors. Tarascon Internal Medicine and Critical Care Pocketbook. 2004; 44-55.
  85. Chen YH, Layne MD, Chung SW, Ejima K, Baron RM, Yet SF, Perrella MA. Elk-3 is a transcriptional repressor of nitric-oxide synthase 2. J Biol Chem. 2003 Oct 10; 278(41):39572-7. PMID: 12896968.
    Citations: 11     Fields:    Translation:AnimalsCells
  86. Ejima K, Layne MD, Carvajal IM, Kritek PA, Baron RM, Chen YH, Vom Saal J, Levy BD, Yet SF, Perrella MA. Cyclooxygenase-2-deficient mice are resistant to endotoxin-induced inflammation and death. FASEB J. 2003 Jul; 17(10):1325-7. PMID: 12738799.
    Citations: 40     Fields:    Translation:Animals
  87. Baron R.M., Carvajal I.M., Ejima K., Chen Y.H., Ith B., Layne M.D., Yet S.F., Perrella M.A. Distamycin A Inhibits Binding of High Mobility Group-I/Y Protein to the Nitric Oxide Synthase 2 Promoter and Improves Mouse Survival from Endotoxemia [abstract] . Am J Resp Crit Care Med. 2003; 28:A728.
  88. Baron RM, Carvajal IM, Fredenburgh LE, Liu X, Porrata Y, Haley KJ, Sonna LA, De Sanctis GT, Ingenito EP, Perrella MA . NOS2 downregulates expression of SP-B and enhances endotoxin-induced lung injury in mice [abstract]. Circulation. 2003.
  89. Baron RM, Fanta CH. Hemoptysis. Branch WT, editor. Office Practice of Medicine. 2003; 285-292.
  90. Chen Y-H, Layne MD, Ejima K, Baron RM, Yet S-F, Perrella MA. Elk3 Is a Transcriptional Repressor of Nitric Oxide Synthase 2 in Macrophages [abstract] . Am J Resp Crit Care Med. 2003; 28:A50.
  91. Silverman ES, Baron RM, Palmer LJ, Le L, Hallock A, Subramaniam V, Riese RJ, McKenna MD, Gu X, Libermann TA, Tugores A, Haley KJ, Shore S, Drazen JM, Weiss ST. Constitutive and cytokine-induced expression of the ETS transcription factor ESE-3 in the lung. Am J Respir Cell Mol Biol. 2002 Dec; 27(6):697-704. PMID: 12444029.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  92. Baron RM, Palmer LJ, Tantisira K, Gabriel S, Sonna LA, Le L, Hallock A, Libermann TA, Drazen JM, Weiss ST, Silverman ES. DNA sequence variants in epithelium-specific ETS-2 and ETS-3 are not associated with asthma. Am J Respir Crit Care Med. 2002 Oct 01; 166(7):927-32. PMID: 12359648.
    Citations: 5     Fields:    Translation:HumansCells
  93. Storm van's Gravesande K, Layne MD, Ye Q, Le L, Baron RM, Perrella MA, Santambrogio L, Silverman ES, Riese RJ. IFN regulatory factor-1 regulates IFN-gamma-dependent cathepsin S expression. J Immunol. 2002 May 01; 168(9):4488-94. PMID: 11970993.
    Citations: 23     Fields:    Translation:HumansCells
  94. Silverman ES, Le L, Baron RM, Hallock A, Hjoberg J, Shikanai T, Storm van's Gravesande K, Auron PE, Lu W. Cloning and functional analysis of the mouse 5-lipoxygenase promoter. Am J Respir Cell Mol Biol. 2002 Apr; 26(4):475-83. PMID: 11919084.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  95. Baron RM. Book Review: Preoperative Assessment. Ed: Cashman JN [review]. J Intensive Care Med. 2002; 17:96.
  96. Baron RM, Palmer LJ, Haley KH, Sonna L, Freedman M, Gabriel S, Drazen JM, Weiss ST, Silverman ES. An Association Study Of DNA Sequence Variants In The Epithelium-Specific ETS Transcription Factors ESE-2 And ESE-3 With Asthma [abstract] . Am J Resp Crit Care Med. 2002; 26.
  97. Carvajal IM, Baron RM, Perrella MA. High-mobility group-I/Y proteins: Potential role in the pathophysiology of critical illnesses. Crit Care Med. 2002 Jan; 30(1 Supp):S36-S42. PMID: 11891405.
    Citations: 2     Fields:    
  98. Baron RM, Carvajal IM, Pellacani A, Chen Y-H, Ejima K, Ith B, Layne MD, Yet S-F, Perrella MA. High Mobility Group-I/Y Protein Binds To The Interferon Regulatory Region Of Murine Nitric Oxide Synthase 2 Promoter [abstract] . Am J Resp Crit Care Med. 2002; 26.
  99. Ejima K, Layne MD, Kritek PA, Carvajal IM, Baron RM, Ith B, Yet S-F, Perrella MA. Lung Response To Endotoxemia In The Absence Of Cyclooxygeanse-2 [abstract] . Am J Resp Crit Care Med. 2002.
  100. Carvajal IM, Baron RM, Perrella MA. High-mobility group-I/Y proteins: potential role in the pathophysiology of critical illnesses. Crit Care Med. 2002 Jan; 30(1 Suppl):S36-42. PMID: 11782559.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  101. Baron RM, Schwartzstein RM. Diseases of the Chest Wall [review]. UpToDate. 2001.
  102. Silverman ES, Liggett SB, Gelfand EW, Rosenwasser LJ, Baron RM, Bolk S, Weiss ST, Drazen JM. The pharmacogenetics of asthma: a candidate gene approach. Pharmacogenomics J. 2001; 1(1):27-37. PMID: 11913724.
    Citations: 4     Fields:    Translation:Humans
  103. Baron R, Silverman ES, Grasemann H, Collins T, Drazen JM. DNA sequence variants of platelet-derived growth factor A-chain gene. Clin Exp All. 2001; 31:1501-1508.
  104. Silverman ES, Liggett SB, Gelfand EW, Rosenwasser LJ, Baron RM, Bolk S, Weiss ST, Drazen JM. The pharmacogenetics of asthma: A candidate gene approach [review]. Pharmacogenetics. 2001; 1:27-37.
  105. Baron RM, Goldhaber SZ. Deep venous thrombosis: early discharge strategies and outpatient management. J Thromb Thrombolysis. 1999 Apr; 7(2):113-22. PMID: 10364776.
    Citations:    Fields:    Translation:Humans
  106. Miyahara E, Pokorny J, Smith VC, Baron R, Baron E. Color vision in two observers with highly biased LWS/MWS cone ratios. Vision Res. 1998 Feb; 38(4):601-12. PMID: 9536382.
    Citations: 8     Fields:    Translation:HumansCells
  107. Baron RM, Goldhaber SZ. Deep Venous Thrombosis: Early Discharge Strategies and Outpatient Management. J Thromb Thrombolysis. 1997; 4(3/4):365-374. PMID: 10639643.
    Citations:    Fields:    
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.