Harvard Catalyst Profiles

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Jack Timothy Rogers, Ph.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. Pileline award (ROGERS, JACK T.) Oct 1, 2018 - Jan 31, 2022
    Michael J FOX Foundation.
    Developing a Blocker of Alpha-synuclein Production for the Treatment of Parkinson's Disease
    Role Description: Our most promising therapeutic compound, Syn-516, is to be rigorously tested and advanced for the ability to block the translation of SNCA and to reduce the amount of alpha-synuclein in dopamine-producing nerve cells.
    Role: Principal Investigator (Co-PI Dr. Catherine Cahill)
  2. R21NS077079 (ROGERS, JACK T) Jul 1, 2012 - Mar 30, 2015
    Post Transcriptional Control of hemorrhagic iron damage.
    Role: Principal Investigator
  3. R21NS064853 (ROGERS, JACK T) Sep 30, 2008 - Nov 30, 2011
    RNA Targeted Screens of the Prion 5'UTR
    Role: Principal Investigator
  4. R21NS059434 (ROGERS, JACK T) Mar 1, 2007 - Feb 28, 2010
    MLSN Screen of the PD Alpha Synuclein 5'UTR
    Role: Principal Investigator
  5. R03NS053652 (ROGERS, JACK T) Sep 30, 2005 - Aug 31, 2008
    HTS Molecules Targeting APP 5'untranslated Region(RMI)
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wuli W, Lin SZ, Chen SP, Tannous BA, Huang WS, Woon PY, Wu YC, Yang HH, Chen YC, Fleming RL, Rogers JT, Cahill CM, Ho TJ, Chiou TW, Harn HJ. Targeting PSEN1 by lnc-CYP3A43-2/miR-29b-2-5p to Reduce ß Amyloid Plaque Formation and Improve Cognition Function. Int J Mol Sci. 2022 Sep 11; 23(18). PMID: 36142465.
    Citations: 1     Fields:    Translation:Animals
  2. Chen XQ, Barrero CA, Vasquez-Del Carpio R, Reddy EP, Fecchio C, Merali S, Deglincerti A, Fang C, Rogers J, Maccecchini ML. Posiphen Reduces the Levels of Huntingtin Protein through Translation Suppression. Pharmaceutics. 2021 Dec 07; 13(12). PMID: 34959389.
    Citations: 1     
  3. Lahiri DK, Maloney B, Wang R, Sokol DK, Rogers JT, Westmark CJ. How autism and Alzheimer's disease are TrAPPed. Mol Psychiatry. 2021 01; 26(1):26-29. PMID: 33184495; PMCID: PMC9487718.
    Citations: 4     Fields:    Translation:HumansAnimals
  4. Cahill CM, Aleyadeh R, Gao J, Wang C, Rogers JT. Alpha-Synuclein in Alcohol Use Disorder, Connections with Parkinson's Disease and Potential Therapeutic Role of 5' Untranslated Region-Directed Small Molecules. Biomolecules. 2020 10 21; 10(10). PMID: 33096655.
    Citations:    Fields:    Translation:HumansCells
  5. Liu W, Xin Y, Li Q, Shang Y, Ping Z, Min J, Cahill CM, Rogers JT, Wang F. Biomarkers of environmental manganese exposure and associations with childhood neurodevelopment: a systematic review and meta-analysis. Environ Health. 2020 10 02; 19(1):104. PMID: 33008482.
    Citations: 5     Fields:    Translation:HumansPHPublic Health
  6. Rogers JT, Cahill CM. Iron-responsive-like elements and neurodegenerative ferroptosis. Learn Mem. 2020 09; 27(9):395-413. PMID: 32817306.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  7. Pilozzi A, Yu Z, Carreras I, Cormier K, Hartley D, Rogers J, Dedeoglu A, Huang X. A Preliminary Study of Cu Exposure Effects upon Alzheimer's Amyloid Pathology. Biomolecules. 2020 03 06; 10(3). PMID: 32155778.
    Citations:    Fields:    Translation:HumansAnimalsCells
  8. Mou X, Pilozzi A, Tailor B, Yi J, Cahill C, Rogers J, Huang X. Exposure to CuO Nanoparticles Mediates NF?B Activation and Enhances Amyloid Precursor Protein Expression. Biomedicines. 2020 Feb 27; 8(3). PMID: 32120908; PMCID: PMC7175332.
    Citations: 2     
  9. Kisby B, Jarrell JT, Agar ME, Cohen DS, Rosin ER, Cahill CM, Rogers JT, Huang X. Alzheimer's Disease and Its Potential Alternative Therapeutics. J Alzheimers Dis Parkinsonism. 2019; 9(5). PMID: 31588368; PMCID: PMC6777730.
    Citations: 6     
  10. Taylor Levine M, Gao J, Satyanarayanan SK, Berman S, Rogers JT, Mischoulon D. S-adenosyl-l-methionine (SAMe), cannabidiol (CBD), and kratom in psychiatric disorders: Clinical and mechanistic considerations. Brain Behav Immun. 2020 03; 85:152-161. PMID: 31301401.
    Citations:    Fields:    Translation:HumansAnimals
  11. Rogers JT, Xia N, Wong A, Bakshi R, Cahill CM. Targeting the Iron-Response Elements of the mRNAs for the Alzheimer's Amyloid Precursor Protein and Ferritin to Treat Acute Lead and Manganese Neurotoxicity. Int J Mol Sci. 2019 Feb 25; 20(4). PMID: 30823541; PMCID: PMC6412244.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  12. Kuo YM, Nwankwo EI, Nussbaum RL, Rogers J, Maccecchini ML. Translational inhibition of a-synuclein by Posiphen normalizes distal colon motility in transgenic Parkinson mice. Am J Neurodegener Dis. 2019; 8(1):1-15. PMID: 30906671; PMCID: PMC6420700.
    Citations: 10     
  13. Long JM, Maloney B, Rogers JT, Lahiri DK. Novel upregulation of amyloid-ß precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5'-untranslated region: Implications in Alzheimer's disease. Mol Psychiatry. 2019 03; 24(3):345-363. PMID: 30470799; PMCID: PMC6514885.
    Citations: 49     Fields:    Translation:HumansCells
  14. Venkataramani V, Doeppner TR, Willkommen D, Cahill CM, Xin Y, Ye G, Liu Y, Southon A, Aron A, Au-Yeung HY, Huang X, Lahiri DK, Wang F, Bush AI, Wulf GG, Ströbel P, Michalke B, Rogers JT. Manganese causes neurotoxic iron accumulation via translational repression of amyloid precursor protein and H-Ferritin. J Neurochem. 2018 12; 147(6):831-848. PMID: 30152072; PMCID: PMC6310653.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  15. Lumsden AL, Rogers JT, Majd S, Newman M, Sutherland GT, Verdile G, Lardelli M. Dysregulation of Neuronal Iron Homeostasis as an Alternative Unifying Effect of Mutations Causing Familial Alzheimer's Disease. Front Neurosci. 2018; 12:533. PMID: 30150923; PMCID: PMC6099262.
    Citations: 14     
  16. Gao J, Cahill CM, Huang X, Roffman JL, Lamon-Fava S, Fava M, Mischoulon D, Rogers JT. S-Adenosyl Methionine and Transmethylation Pathways in Neuropsychiatric Diseases Throughout Life. Neurotherapeutics. 2018 01; 15(1):156-175. PMID: 29340929.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  17. Song N, Wang W, Jia F, Du X, Xie A, He Q, Shen X, Zhang J, Rogers JT, Xie J, Jiang H. Assessments of plasma ghrelin levels in the early stages of parkinson's disease. Mov Disord. 2017 Oct; 32(10):1487-1491. PMID: 28681931.
    Citations: 23     Fields:    Translation:Humans
  18. Meng T, Cao Q, Lei P, Bush AI, Xiang Q, Su Z, He X, Rogers JT, Chiu IM, Zhang Q, Huang Y. Tat-haFGF14-154 Upregulates ADAM10 to Attenuate the Alzheimer Phenotype of APP/PS1 Mice through the PI3K-CREB-IRE1a/XBP1 Pathway. Mol Ther Nucleic Acids. 2017 Jun 16; 7:439-452. PMID: 28624220; PMCID: PMC5443968.
    Citations: 12     
  19. Rogers JT, Venkataramani V, Washburn C, Liu Y, Tummala V, Jiang H, Smith A, Cahill CM. A role for amyloid precursor protein translation to restore iron homeostasis and ameliorate lead (Pb) neurotoxicity. J Neurochem. 2016 08; 138(3):479-94. PMID: 27206843.
    Citations: 21     Fields:    Translation:HumansCells
  20. Plascencia-Villa G, Ponce A, Collingwood JF, Arellano-Jiménez MJ, Zhu X, Rogers JT, Betancourt I, José-Yacamán M, Perry G. High-resolution analytical imaging and electron holography of magnetite particles in amyloid cores of Alzheimer's disease. Sci Rep. 2016 04 28; 6:24873. PMID: 27121137; PMCID: PMC4848473.
    Citations: 39     Fields:    Translation:Humans
  21. Cahill CM, Zhu W, Oziolor E, Yang YJ, Tam B, Rajanala S, Rogers JT, Walker WA. Differential Expression of the Activator Protein 1 Transcription Factor Regulates Interleukin-1ß Induction of Interleukin 6 in the Developing Enterocyte. PLoS One. 2016; 11(1):e0145184. PMID: 26799482.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  22. Ayton S, Lei P, Hare DJ, Duce JA, George JL, Adlard PA, McLean C, Rogers JT, Cherny RA, Finkelstein DI, Bush AI. Parkinson's disease iron deposition caused by nitric oxide-induced loss of ß-amyloid precursor protein. J Neurosci. 2015 Feb 25; 35(8):3591-7. PMID: 25716857; PMCID: PMC6605561.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  23. Bandyopadhyay S, Rogers JT. Alzheimer's disease therapeutics targeted to the control of amyloid precursor protein translation: maintenance of brain iron homeostasis. Biochem Pharmacol. 2014 Apr 15; 88(4):486-94. PMID: 24513321.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  24. Tao Y, Wang Y, Rogers JT, Wang F. Perturbed iron distribution in Alzheimer's disease serum, cerebrospinal fluid, and selected brain regions: a systematic review and meta-analysis. J Alzheimers Dis. 2014; 42(2):679-90. PMID: 24916541.
    Citations: 47     Fields:    Translation:Humans
  25. Bandyopadhyay S, Cahill C, Balleidier A, Huang C, Lahiri DK, Huang X, Rogers JT. Novel 5' untranslated region directed blockers of iron-regulatory protein-1 dependent amyloid precursor protein translation: implications for down syndrome and Alzheimer's disease. PLoS One. 2013; 8(7):e65978. PMID: 23935819.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  26. Hahl P, Davis T, Washburn C, Rogers JT, Smith A. Mechanisms of neuroprotection by hemopexin: modeling the control of heme and iron homeostasis in brain neurons in inflammatory states. J Neurochem. 2013 Apr; 125(1):89-101. PMID: 23350672.
    Citations: 31     Fields:    Translation:HumansCells
  27. Lahiri DK, Maloney B, Rogers JT, Ge YW. PuF, an antimetastatic and developmental signaling protein, interacts with the Alzheimer's amyloid-ß precursor protein via a tissue-specific proximal regulatory element (PRE). BMC Genomics. 2013 Jan 31; 14:68. PMID: 23368879.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  28. Hu B, Jiang G, Pang C, Wang S, Liu Q, Chen Z, Vanderburg CR, Rogers JT, Deng Y, Huang X. Assessment of gene order computing methods for Alzheimer's disease. BMC Med Genomics. 2013; 6 Suppl 1:S8. PMID: 23369541.
    Citations: 2     Fields:    Translation:Humans
  29. Yu QS, Reale M, Kamal MA, Holloway HW, Luo W, Sambamurti K, Ray B, Lahiri DK, Rogers JT, Greig NH. Synthesis of the Alzheimer drug Posiphen into its primary metabolic products (+)-N1-norPosiphen, (+)-N8-norPosiphen and (+)-N1, N8-bisnorPosiphen, their inhibition of amyloid precursor protein, a-Synuclein synthesis, interleukin-1ß release, and cholinergic action. Antiinflamm Antiallergy Agents Med Chem. 2013; 12(2):117-28. PMID: 23360256.
    Citations: 16     Fields:    Translation:Humans
  30. Olivares D, Deshpande VK, Shi Y, Lahiri DK, Greig NH, Rogers JT, Huang X. N-methyl D-aspartate (NMDA) receptor antagonists and memantine treatment for Alzheimer's disease, vascular dementia and Parkinson's disease. Curr Alzheimer Res. 2012 Jul; 9(6):746-58. PMID: 21875407.
    Citations: 94     Fields:    Translation:HumansAnimals
  31. Mikkilineni S, Cantuti-Castelvetri I, Cahill CM, Balliedier A, Greig NH, Rogers JT. The anticholinesterase phenserine and its enantiomer posiphen as 5'untranslated-region-directed translation blockers of the Parkinson's alpha synuclein expression. Parkinsons Dis. 2012; 2012:142372. PMID: 22693681; PMCID: PMC3368596.
    Citations: 25     
  32. David Olivares, Varun K. Deshpande, Ying Shi, Debomoy K. Lahiri, Nigel H. Greig, Jack T. Rogers, and Xudong Huang. N-Methyl D-Aspartate (NMDA) Receptor Antagonists and Memantine Treatment for Alzheimer’s Disease, Vascular Dementia and Parkinson’s Disease. Current Alzheimer Research. 2012; 9:1000.
  33. Cahill, CM., Rogers, JT., Walker, A. J. Signal Transduction. The role of phosphoinositide-3-kinase signaling intestinal Inflammation. 2012; ID 358476:1-13.
  34. Duce JA, Ayton S, Miller AA, Tsatsanis A, Lam LQ, Leone L, Corbin JE, Butzkueven H, Kilpatrick TJ, Rogers JT, Barnham KJ, Finkelstein DI, Bush AI. Amine oxidase activity of ß-amyloid precursor protein modulates systemic and local catecholamine levels. Mol Psychiatry. 2013 Feb; 18(2):245-54. PMID: 22212595.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  35. Rogers JT, Mikkilineni S, Cantuti-Castelvetri I, Smith DH, Huang X, Bandyopadhyay S, Cahill CM, Maccecchini ML, Lahiri DK, Greig NH. The alpha-synuclein 5'untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen. J Neural Transm (Vienna). 2011 Mar; 118(3):493-507. PMID: 21221670.
    Citations: 33     Fields:    Translation:HumansCells
  36. Bandyopadhyay S, Huang X, Lahiri DK, Rogers JT. Novel drug targets based on metallobiology of Alzheimer's disease. Expert Opin Ther Targets. 2010 Nov; 14(11):1177-97. PMID: 20942746.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  37. Duce JA, Tsatsanis A, Cater MA, James SA, Robb E, Wikhe K, Leong SL, Perez K, Johanssen T, Greenough MA, Cho HH, Galatis D, Moir RD, Masters CL, McLean C, Tanzi RE, Cappai R, Barnham KJ, Ciccotosto GD, Rogers JT, Bush AI. Iron-export ferroxidase activity of ß-amyloid precursor protein is inhibited by zinc in Alzheimer's disease. Cell. 2010 Sep 17; 142(6):857-67. PMID: 20817278.
    Citations: 237     Fields:    Translation:HumansAnimalsCells
  38. Cho HH, Cahill CM, Vanderburg CR, Scherzer CR, Wang B, Huang X, Rogers JT. Selective translational control of the Alzheimer amyloid precursor protein transcript by iron regulatory protein-1. J Biol Chem. 2010 Oct 08; 285(41):31217-32. PMID: 20558735.
    Citations: 81     Fields:    Translation:HumansAnimalsCells
  39. Pang CY, Hu W, Hu BQ, Shi Y, Vanderburg CR, Rogers JT, Huang X. A special local clustering algorithm for identifying the genes associated with Alzheimer's disease. IEEE Trans Nanobioscience. 2010 Mar; 9(1):44-50. PMID: 20089478.
    Citations: 2     Fields:    Translation:Humans
  40. Maloney B, Ge YW, Petersen RC, Hardy J, Rogers JT, Pérez-Tur J, Lahiri DK. Functional characterization of three single-nucleotide polymorphisms present in the human APOE promoter sequence: Differential effects in neuronal cells and on DNA-protein interactions. Am J Med Genet B Neuropsychiatr Genet. 2010 Jan 05; 153B(1):185-201. PMID: 19504470.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  41. Zhao W, Liu Y, Cahill CM, Yang W, Rogers JT, Huang X. The role of T cells in osteoporosis, an update. Int J Clin Exp Pathol. 2009 May 20; 2(6):544-52. PMID: 19636401.
    Citations: 11     Fields:    
  42. Olivares D, Huang X, Branden L, Greig NH, Rogers JT. Physiological and pathological role of alpha-synuclein in Parkinson's disease through iron mediated oxidative stress; the role of a putative iron-responsive element. Int J Mol Sci. 2009 Mar; 10(3):1226-60. PMID: 19399246; PMCID: PMC2672027.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  43. Kong W, Mou X, Liu Q, Chen Z, Vanderburg CR, Rogers JT, Huang X. Independent component analysis of Alzheimer's DNA microarray gene expression data. Mol Neurodegener. 2009 Jan 28; 4:5. PMID: 19173745.
    Citations: 30     Fields:    
  44. Cahill CM, Lahiri DK, Huang X, Rogers JT. Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases. Biochim Biophys Acta. 2009 Jul; 1790(7):615-28. PMID: 19166904.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  45. Rogers JT, Bush AI, Cho HH, Smith DH, Thomson AM, Friedlich AL, Lahiri DK, Leedman PJ, Huang X, Cahill CM. Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease. Biochem Soc Trans. 2008 Dec; 36(Pt 6):1282-7. PMID: 19021541.
    Citations: 54     Fields:    Translation:HumansCells
  46. Kong W, Vanderburg CR, Gunshin H, Rogers JT, Huang X. A review of independent component analysis application to microarray gene expression data. Biotechniques. 2008 Nov; 45(5):501-20. PMID: 19007336.
    Citations: 40     Fields:    Translation:HumansCells
  47. Yi J, Horky LL, Friedlich AL, Shi Y, Rogers JT, Huang X. L-arginine and Alzheimer's disease. Int J Clin Exp Pathol. 2009; 2(3):211-38. PMID: 19079617.
    Citations: 24     Fields:    
  48. Qureshi M, Brown RH, Rogers JT, Cudkowicz ME. Serum ferritin and metal levels as risk factors for amyotrophic lateral sclerosis. Open Neurol J. 2008 Sep 12; 2:51-4. PMID: 19452011.
    Citations: 20     
  49. Patel N, Hoang D, Miller N, Ansaloni S, Huang Q, Rogers JT, Lee JC, Saunders AJ. MicroRNAs can regulate human APP levels. Mol Neurodegener. 2008 Aug 06; 3:10. PMID: 18684319.
    Citations: 87     Fields:    
  50. James A. Duce, Jack T. Rogers, Andrew Tsatsanis, Robert D. Moir, Elysia Robb, Su Ling Leong, Susan M. Harding, Amanda Venti, Colin Masters, Roberto Cappai, Rudolph E. Tanzi, Ashley I. Bush. Alzheimer's Disease ß-Amyloid Protein Precursor Is Ferroxidase II, a Ceruloplasmin-like Iron Detoxification Enzyme. Alzheimer Asociation Meeting, Washington DC. 2008.
  51. Cahill CM, Rogers JT. Interleukin (IL) 1beta induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT/IkappaB kinase alpha pathway targeting activator protein-1. J Biol Chem. 2008 Sep 19; 283(38):25900-12. PMID: 18515365.
    Citations: 107     Fields:    Translation:HumansCells
  52. Avi Friedlich, Hyun-Hee Cho, Rudolph Tanzi, Robert Moir, Ashley Bush, Xudong Huang, Jack Rogers. An Iron-Responsive Element in the Alpha Synuclein Transcript (Awarded First Prize). Myselle Harvard-wide Psychiatry Research Symposium. 2008.
  53. Patel AK, Rogers JT, Huang X. Flavanols, mild cognitive impairment, and Alzheimer's dementia. Int J Clin Exp Med. 2008; 1(2):181-91. PMID: 19079672.
    Citations: 11     
  54. Chen J, Zhu J, Cho H-H, Cui K, Li F, Zhou X, Rogers JT, Huang X., Wong STC . Differential cytotoxicity of metal oxide nanoparticles. Journal of Experimental Nanoscience. 2008; Accepted and In Press.
  55. Hyun-Hee Cho, Marcie Glicksman, Juliet Moncaster, Lee Goldstein2, Ashley Bush, Catherine Cahill, Xudong Huang, Jack Rogers. . Iron-responsive Translational Control of the Amyloid Precursor Protein, Novel Ferroxidase Activity of Its Secreted fragments, and Its 5’UTR as a Therapeutic Target for Alzheimer's Disease. . Journal of Trace Metals. 2007.
  56. Friedlich AL, Tanzi RE, Rogers JT. The 5'-untranslated region of Parkinson's disease alpha-synuclein messengerRNA contains a predicted iron responsive element. Mol Psychiatry. 2007 Mar; 12(3):222-3. PMID: 17325711.
    Citations: 66     Fields:    Translation:Humans
  57. Bandyopadhyay S, Goldstein LE, Lahiri DK, Rogers JT. Role of the APP non-amyloidogenic signaling pathway and targeting alpha-secretase as an alternative drug target for treatment of Alzheimer's disease. Curr Med Chem. 2007; 14(27):2848-64. PMID: 18045131.
    Citations: 30     Fields:    Translation:HumansCells
  58. Lahiri DK, Ge YW, Rogers JT, Sambamurti K, Greig NH, Maloney B. Taking down the unindicted co-conspirators of amyloid beta-peptide-mediated neuronal death: shared gene regulation of BACE1 and APP genes interacting with CREB, Fe65 and YY1 transcription factors. Curr Alzheimer Res. 2006 Dec; 3(5):475-83. PMID: 17168646.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  59. Tucker S, Ahl M, Cho HH, Bandyopadhyay S, Cuny GD, Bush AI, Goldstein LE, Westaway D, Huang X, Rogers JT. RNA therapeutics directed to the non coding regions of APP mRNA, in vivo anti-amyloid efficacy of paroxetine, erythromycin, and N-acetyl cysteine. Curr Alzheimer Res. 2006 Jul; 3(3):221-7. PMID: 16842099.
    Citations: 28     Fields:    Translation:AnimalsCells
  60. Bandyopadhyay S, Hartley DM, Cahill CM, Lahiri DK, Chattopadhyay N, Rogers JT. Interleukin-1alpha stimulates non-amyloidogenic pathway by alpha-secretase (ADAM-10 and ADAM-17) cleavage of APP in human astrocytic cells involving p38 MAP kinase. J Neurosci Res. 2006 Jul; 84(1):106-18. PMID: 16724341.
    Citations: 21     Fields:    Translation:HumansCells
  61. Andrew Tsatsanis, Michael Cater, Stephanie Tucker, Robert D. Moir, Rudolph E. Tanzi, Jack T. Rogers, Ashley I. Bush. Endogenous human APP possesses oxidase activity. Neurobiology of Aging (Alzheimer's Association International Meeting in Madrid, Spain). 2006.
  62. Bandyopadhyay S, Ni J, Ruggiero A, Walshe K, Rogers MS, Chattopadhyay N, Glicksman MA, Rogers JT. A high-throughput drug screen targeted to the 5'untranslated region of Alzheimer amyloid precursor protein mRNA. J Biomol Screen. 2006 Aug; 11(5):469-80. PMID: 16928984.
    Citations: 23     Fields:    Translation:HumansCells
  63. Liu G, Huang W, Moir RD, Vanderburg CR, Lai B, Peng Z, Tanzi RE, Rogers JT, Huang X. Metal exposure and Alzheimer's pathogenesis. J Struct Biol. 2006 Jul; 155(1):45-51. PMID: 16503166.
    Citations: 42     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  64. Bandyopadhyay S, Huang X, Cho H, Greig NH, Youdim MB, Rogers JT. Metal specificity of an iron-responsive element in Alzheimer's APP mRNA 5'untranslated region, tolerance of SH-SY5Y and H4 neural cells to desferrioxamine, clioquinol, VK-28, and a piperazine chelator. J Neural Transm Suppl. 2006; (71):237-47. PMID: 17447434.
    Citations: 21     Fields:    Translation:HumansCells
  66. Rogers, JT. APP and Ferritin Translation, Metals and Alzheimer's Disease. Sessler, J, editor. Metals in Medicine, J. Am. Chem Soc. 2005; 215-251.
  67. Thomson AM, Cahill CM, Cho HH, Kassachau KD, Epis MR, Bridges KR, Leedman PJ, Rogers JT. The acute box cis-element in human heavy ferritin mRNA 5'-untranslated region is a unique translation enhancer that binds poly(C)-binding proteins. J Biol Chem. 2005 Aug 26; 280(34):30032-45. PMID: 15967798.
    Citations: 18     Fields:    Translation:HumansCells
  68. Tucker S, Ahl M, Bush A, Westaway D, Huang X, Rogers JT. Pilot study of the reducing effect on amyloidosis in vivo by three FDA pre-approved drugs via the Alzheimer's APP 5' untranslated region. Curr Alzheimer Res. 2005 Apr; 2(2):249-54. PMID: 15974925.
    Citations: 22     Fields:    Translation:Animals
  69. Rogers, JT., Greig, N.H., Lahiri, DK., Fisher, A. Translation and Processing of the Amyloid Precursor Protein in response to an M1 muscaric agonist and an acetyl cholinesterase inhibitor. Therapeutic strategies in Neurodegenerative Diseases. Fisher, A and Hanin, I, eds. 2005; 35:265-278.
  70. Lahiri DK, Chen D, Lahiri P, Rogers JT, Greig NH, Bondy S. Melatonin, metals, and gene expression: implications in aging and neurodegenerative disorders. Ann N Y Acad Sci. 2004 Dec; 1035:216-30. PMID: 15681810.
    Citations: 5     Fields:    Translation:HumansAnimals
  71. Venti A, Giordano T, Eder P, Bush AI, Lahiri DK, Greig NH, Rogers JT. The integrated role of desferrioxamine and phenserine targeted to an iron-responsive element in the APP-mRNA 5'-untranslated region. Ann N Y Acad Sci. 2004 Dec; 1035:34-48. PMID: 15681799.
    Citations: 24     Fields:    Translation:HumansCells
  72. Greig NH, Mattson MP, Perry T, Chan SL, Giordano T, Sambamurti K, Rogers JT, Ovadia H, Lahiri DK. New therapeutic strategies and drug candidates for neurodegenerative diseases: p53 and TNF-alpha inhibitors, and GLP-1 receptor agonists. Ann N Y Acad Sci. 2004 Dec; 1035:290-315. PMID: 15681814.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  73. Dedeoglu A, Cormier K, Payton S, Tseitlin KA, Kremsky JN, Lai L, Li X, Moir RD, Tanzi RE, Bush AI, Kowall NW, Rogers JT, Huang X. Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis. Exp Gerontol. 2004 Nov-Dec; 39(11-12):1641-9. PMID: 15582280.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  74. Rogers JT, Lahiri DK. Metal and inflammatory targets for Alzheimer's disease. Curr Drug Targets. 2004 Aug; 5(6):535-51. PMID: 15270200.
    Citations: 45     Fields:    Translation:HumansAnimals
  75. Payton, S and Rogers, JT. Drug Discovery for Alzheimer's Disease Targeted to the APP 5'untranslated region. Harvard University Research Day (Mysell Research Colloquium). 2004.
  76. Huang X, Moir RD, Tanzi RE, Bush AI, Rogers JT. Redox-active metals, oxidative stress, and Alzheimer's disease pathology. Ann N Y Acad Sci. 2004 Mar; 1012:153-63. PMID: 15105262.
    Citations: 92     Fields:    Translation:HumansAnimalsCells
  77. Morse LJ, Payton SM, Cuny GD, Rogers JT. FDA-preapproved drugs targeted to the translational regulation and processing of the amyloid precursor protein. J Mol Neurosci. 2004; 24(1):129-36. PMID: 15314261.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  78. NH. Greig, MP. Mattson, TA Perry, S Chan, T Giordano, K Sambamurti, J Rogers, H Ovadia, DK. Lahiri. New Therapeutic Strategies And Drug Candidates For Neurodegenerative Diseases. Ann NY Acad Sci. 2004; 1035:290-315.
  79. Lahiri DK, Rogers JT, Greig NH, Sambamurti K. Rationale for the development of cholinesterase inhibitors as anti-Alzheimer agents. Curr Pharm Des. 2004; 10(25):3111-9. PMID: 15544501.
    Citations: 21     Fields:    Translation:HumansAnimals
  80. Venti, A., Giordano, T., Eder, P., Bush, A., Lahiri, DK., Greig, N., Rogers, JT. Integrated role of desferrioxamine and phenserine Targeted to the Iron Responsive Element in the 5'UTR of the APP transcript. Ann NY. Acad. Sci. 2004; 1035:34-48.
  81. 17. Lahiri DK, Chen D, Lahiri P, Rogers JT, Greig NH, Bondy S. . Melatonin, Metals And Gene Expression: Implications In Aging And Neurodegenerative Disorders. Ann NY Acad Sci. 2004; 1035:216-30..
  82. Jack T. Rogers, Stephanie Tucker, Sandra Payton, Nigel H. Greig, Rick Jensen, Greg Cuny, Debomoy K. Lahiri, Lee Jae Morse, Rudolph E. Tanzi, David Westaway, Ashley Bush, Steve Gullans, Satinder Sarang, Xudong Huang . Alzheimer's disease drug discovery targeted to the APP mRNA 5' untranslated region: a validated target. Neurobiology of Aging, AD meeting in Philadelphia. 2004.
  83. Greig NH, Giordano T, Zhu X, Yu QS, Perry TA, Holloway HW, Brossi A, Rogers JT, Sambamurti K, Lahiri DK. Thalidomide-based TNF-alpha inhibitors for neurodegenerative diseases. Acta Neurobiol Exp (Wars). 2004; 64(1):1-9. PMID: 15190675.
    Citations: 22     Fields:    Translation:HumansCells
  84. Huang, X., Moir, RD., Tanzi, RD., Bush, AI., Rogers, JT. Redox-active Metals, Oxidative Stress, and Alzheimer's Disease Pathology. Ann. NY. Acad. Sci. 2004; 1012:153-163.
  85. Jack T. Rogers, Lee Jae Morse, Michael Lombardi, Patrick Devaney, Roderick Jensen. Metallothionein 3 gene expression is up-regulated by intracellular iron chelation, the role of a putative Iron-responsive Element in the 3’untranslated region. Neurobiology of Aging, AD meeting in Philadelphia, PA. 2004.
  88. Rogers JT. Payton, S., Gullans, S., Randall, J., Sarang, S Patent pending. METHODS AND COMPOSITIONS FOR MODULATING AMYLOID PRECURSOR PROTEIN TRANSLATION. 2003.
  89. Lahiri DK, Chen D, Vivien D, Ge YW, Greig NH, Rogers JT. Role of cytokines in the gene expression of amyloid beta-protein precursor: identification of a 5'-UTR-binding nuclear factor and its implications in Alzheimer's disease. J Alzheimers Dis. 2003 Apr; 5(2):81-90. PMID: 12719626.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  90. Friedlich, A, Huang, X., Nagano, S., Rogers, JT., Goldstein, L., Bush., AI., Multhaup, G., Beyreuther, K., Stremmel, W., Bayer, T . Importance of copper and zinc in Alzheimer’s disease and the biology of the beta amyloid protein and amyloid precursor protein. Metal Ions and Neurodegenerative Disease. 2003.
  91. Payton S, Cahill CM, Randall JD, Gullans SR, Rogers JT. Drug discovery targeted to the Alzheimer's APP mRNA 5'-untranslated region: the action of paroxetine and dimercaptopropanol. J Mol Neurosci. 2003; 20(3):267-75. PMID: 14501007.
    Citations: 23     Fields:    Translation:HumansCells
  92. Rogers, JT., Payton, S., Greig, N., Lahiri, DK., Fisher A. . An M1 muscarinic agonist and an acetylcholinesterase inhibitor alter translation and processing of the Amyloid Proecursor Protein (APP). AD/PD conference, Seville Spain. 2003.
  93. Rogers JT, Randall JD, Cahill CM, Eder PS, Huang X, Gunshin H, Leiter L, McPhee J, Sarang SS, Utsuki T, Greig NH, Lahiri DK, Tanzi RE, Bush AI, Giordano T, Gullans SR. An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript. J Biol Chem. 2002 Nov 22; 277(47):45518-28. PMID: 12198135.
    Citations: 193     Fields:    Translation:HumansAnimalsCells
  94. Rogers JT, Randall JD, Eder PS, Huang X, Bush AI, Tanzi RE, Venti A, Payton SM, Giordano T, Nagano S, Cahill CM, Moir R, Lahiri DK, Greig N, Sarang SS, Gullans SR. Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated region. J Mol Neurosci. 2002 Aug-Oct; 19(1-2):77-82. PMID: 12212798.
    Citations: 17     Fields:    Translation:HumansCells
  95. Rogers, JT et al. Ferroxidase activity in APP(s)). Neurobiology of Aging, AD Meeting in Stockholm, Sweden. 2002; 23(15):5 S509 .
  96. Rogers,JT., Huang, X., Bush, AI . Therapeutic Targets for Alzheimer's Disease. Neuroprotection, Eng. Lo and Joseph Martwah, Eds. 2002.
  97. Rogers, JT. et al. . APP 5’UTR RNA targeting as a therapeutic strategy for Alzheimer's Disease. Neurobiology of Aging, AD meeting in Stockholm, Sweden. 2002; 23(15):S79.
  98. Gunshin H, Allerson CR, Polycarpou-Schwarz M, Rofts A, Rogers JT, Kishi F, Hentze MW, Rouault TA, Andrews NC, Hediger MA. Iron-dependent regulation of the divalent metal ion transporter. FEBS Lett. 2001 Dec 07; 509(2):309-16. PMID: 11741608.
    Citations: 101     Fields:    Translation:HumansCells
  100. D.K. Lahiri, T. Utsuki, K.T.Y. Shaw, Y.-W. Ge, K. Sambamurti, P.S. Eder, J. T. Rogers, M.R. Farlow, T. Giordino, N.H. Greig. (2001). . Pheserine regulates translation of the beta-amyloid precursor protein message. Mapping the Progress of Alzheimer's and Parkinson's Disease, Yoshikuni Mizuno, Abraham Fisher, Israel Hanin (Eds). 2001.
  101. Shaw, KTT., Utsuki, T., Rogers, JT., Yu, Q-S., Grieg, NH. Translational regulation of Alzheimer's beta-amyloid Precursor Protein mRNA by a putative interleukin-1 responsive element, a new target for drug development. Proc Natl Acad Sci USA. 2001; 98:7605-7610.
  102. Rogers JT. . Targeting an RNA structure in the Alzheimer's amyloid precursor protein gene as a new therapeutic strategy for Alzheimer's disease. H Fillit and Alan O’Connell, Eds. 2001; 74-88.
  103. Thomson AM, Rogers JT, Leedman PJ. Thyrotropin-releasing hormone and epidermal growth factor regulate iron-regulatory protein binding in pituitary cells via protein kinase C-dependent and -independent signaling pathways. J Biol Chem. 2000 Oct 13; 275(41):31609-15. PMID: 10889193.
    Citations: 9     Fields:    Translation:AnimalsCells
  104. Bush AI, Atwood CS, Goldstein LE, Huang X, Rogers J. Could Abeta and AbetaPP be Antioxidants? J Alzheimers Dis. 2000 Jun; 2(2):83-84. PMID: 12214093.
    Citations: 2     Fields:    
  105. Rogers, JT., Moir, RD., Huang, X., Venti, A., Sarhan, N., Van Nostrand, WE., Tanzi, R., Bush, AI. Intrinsic Ferroxidase activity in the Alzheimer's Amyloid Precursor Protein. Neurobiology of Aging, AD meeting in Washington, DC. 2000; 21:S261.
  106. Thomson AM, Rogers JT, Walker CE, Staton JM, Leedman PJ. Optimized RNA gel-shift and UV cross-linking assays for characterization of cytoplasmic RNA-protein interactions. Biotechniques. 1999 Nov; 27(5):1032-9, 1042. PMID: 10572651.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  107. Thomson AM, Rogers JT, Leedman PJ. Iron-regulatory proteins, iron-responsive elements and ferritin mRNA translation. Int J Biochem Cell Biol. 1999 Oct; 31(10):1139-52. PMID: 10582343.
    Citations: 72     Fields:    Translation:HumansAnimalsCells
  108. Rogers JT, Leiter LM, McPhee J, Cahill CM, Zhan SS, Potter H, Nilsson LN. Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences. J Biol Chem. 1999 Mar 05; 274(10):6421-31. PMID: 10037734.
    Citations: 91     Fields:    Translation:HumansCells
  109. Toth I, Yuan L, Rogers JT, Boyce H, Bridges KR. Hypoxia alters iron-regulatory protein-1 binding capacity and modulates cellular iron homeostasis in human hepatoma and erythroleukemia cells. J Biol Chem. 1999 Feb 12; 274(7):4467-73. PMID: 9933651.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  110. Cahill CM, Rogers JT. Anti-idiotypic sera against monoclonal anti-porcine growth hormone antibodies: production in rabbits and characterization of specificity. J Immunoassay. 1999 Feb-May; 20(1-2):45-55. PMID: 10225514.
    Citations:    Fields:    Translation:AnimalsCells
  111. Rogers, JT, Potter, H., Nilsson, L . Amyloid Precursor Protein gene regulation at the translational level by Interleukin-1 and iron. Society for Neuroscience 29th Annual meeting in Miami. 1999.
  112. Venti, A., Moir, R., Bridges, KR., Tanzi, RE., Bush, AI., Rogers, JT. . The amino terminus of secreted APP exhibits ferroxidase activity. American Society for Cell Biology Congress in Washington DC. 1999.
  113. Rogers, JT. Gunshin, H. Andrews, I Toth, L Leiter, X Huang, R.L Nilsson, K Bridges, H Potter, N Andrews D. Selkoe, R Tanzi, A Bush. Translational control of the Alzheimer's Amyloid Precursor Protein. Abstract/paper submitted to the conference on Aging, American Federation of Aging Research (AFAR), Philadelphia. May 1999). 1999.
  114. Nilsson, L., Rogers, JT., Potter, H. The essential role of inflammation and induced gene expression in the pathogenic pathway of Alzheimer's disease. Frontiers in Bioscience. 1998; 3:436-446.
  115. Rogers, JT., Nilsson, L., McPhee, J., Zhan, SS., Potter, H., Leiter, L. . Translational Regulation of the Amyloid Precursor Protein mRNA by Interleukin 1. Society for Neuroscience, Session on Degenerative Diseases: Alzheimer's - Beta Amyloid, Neuroscience meeting in New Orleans. 1997; Abstr: 332.8..
  116. Leedman PJ, Stein AR, Chin WW, Rogers JT. Thyroid hormone modulates the interaction between iron regulatory proteins and the ferritin mRNA iron-responsive element. J Biol Chem. 1996 May 17; 271(20):12017-23. PMID: 8662626.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  117. Rogers JT. Ferritin translation by interleukin-1and interleukin-6: the role of sequences upstream of the start codons of the heavy and light subunit genes. Blood. 1996 Mar 15; 87(6):2525-37. PMID: 8630420.
    Citations: 32     Fields:    Translation:HumansCells
  118. Toth I, Rogers JT, McPhee JA, Elliott SM, Abramson SL, Bridges KR. Ascorbic acid enhances iron-induced ferritin translation in human leukemia and hepatoma cells. J Biol Chem. 1995 Feb 10; 270(6):2846-52. PMID: 7852359.
    Citations: 10     Fields:    Translation:HumansCells
  119. Rogers JT, Andriotakis JL, Lacroix L, Durmowicz GP, Kasschau KD, Bridges KR. Translational enhancement of H-ferritin mRNA by interleukin-1 beta acts through 5' leader sequences distinct from the iron responsive element. Nucleic Acids Res. 1994 Jul 11; 22(13):2678-86. PMID: 8041631; PMCID: PMC308227.
    Citations: 12     Fields:    Translation:HumansCells
  120. Rogers J, Lacroix, L., Durmowicz, G., Kasshau, K., Andriotakis J., Bridges, KR. . Role of cytokines in the regulation of ferritin gene expression. Adv. Exp. Med. Biol. 1994; 356:127-32.
  121. Steel DM, Rogers JT, DeBeer MC, DeBeer FC, Whitehead AS. Biosynthesis of human acute-phase serum amyloid A protein (A-SAA) in vitro: the roles of mRNA accumulation, poly(A) tail shortening and translational efficiency. Biochem J. 1993 May 01; 291 ( Pt 3):701-7. PMID: 8387777; PMCID: PMC1132425.
    Citations: 10     Fields:    Translation:HumansCells
  122. Rogers JT . Genetic Regulation of the Iron Transport and Storage Genes: Links with the Acute Phase Response. Lauffer R editor, Iron and Human Diseases. CRC Press, Boca Raton, 77-104. 1992 .
  123. Rogers JT, Bridges KR, Durmowicz GP, Glass J, Auron PE, Munro HN. Translational control during the acute phase response. Ferritin synthesis in response to interleukin-1. J Biol Chem. 1990 Aug 25; 265(24):14572-8. PMID: 1696948.
    Citations: 52     Fields:    Translation:HumansCells
  124. Munro HN, Leibold EA, Aziz N, Murray MT, White K, Rogers JT . Ferritin Gene Structure and Expression. Ponka P, Schulman HM, Woodworth R, editors, Iron transport and storage, CRC Press, Boca Raton, 133-48. 1990; In: Ponka P, Schulman HM, Wo.
  125. Munro HN, Aziz N, Leibold EA, Murray M, Rogers J, Vass JK, White K. The ferritin genes: structure, expression, and regulation. Ann N Y Acad Sci. 1988; 526:113-23. PMID: 3291676.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  126. Rogers J, Munro HN. Translation of ferritin light and heavy subunits mRNAs is regulated by intracellular chelatable iron levels in rat hepatoma cells. Proc Natl Acad Sci USA. 1987; 84:2277-81.
  127. Munro HN, Leibold EA, Vass JK, Aziz N, Rogers JT, Murray M, White K. . Ferritin gene structure and expression. Spik G, Montreuil J, Crighton RR, Mazurier J, editors. Proteins of Iron Storage and Transport. Proceedings of the VIIth International Conference on Proteins of Iron,. 1985; In: Spik G, Montreuil J, Crigh: 331-41.
  128. Coutelle C, Speer A, Rogers J, Kalsheker N, Humphries S, Williamson R. Construction and partial characterization of a human liver cDNA library. Biomed Biochim Acta. 1985; 44(3):421-31. PMID: 3873938.
    Citations:    Fields:    Translation:HumansAnimalsCells
  129. Myklebost O, Williamson B, Markham AF, Myklebost SR, Rogers J, Woods DE, Humphries SE. The isolation and characterization of cDNA clones for human apolipoprotein CII. J Biol Chem. 1984 Apr 10; 259(7):4401-4. PMID: 6546757.
    Citations: 29     Fields:    Translation:HumansCells
  130. Jack T. Rogers. Use of oligonucleotide screening techniques to identify the human alpha-1 antitrypsin and apolipoprotein CII genes. 1984.
  131. Rogers JT, Kalsheker N, Wallis S, Speer A, Coutelle C, Woods D, Humphries,SE. . The isolation of human alpha1-antitrypsin inhibitor cDNA clones. Biochem Biophys Res Commun. 1983; 116:375-8.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.