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Jack Timothy Rogers, PH.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21NS077079 (ROGERS, JACK T) Jul 1, 2012 - Jun 30, 2014
    NIH/NINDS
    Post Transcriptional Control of hemorrhagic iron damage.
    Role: Principal Investigator
  2. R21NS064853 (ROGERS, JACK T) Sep 30, 2008 - Nov 30, 2011
    NIH/NINDS
    RNA Targeted Screens of the Prion 5'UTR
    Role: Principal Investigator
  3. R21NS059434 (ROGERS, JACK T) Mar 1, 2007 - Feb 28, 2010
    NIH/NINDS
    MLSN Screen of the PD Alpha Synuclein 5'UTR
    Role: Principal Investigator
  4. R03NS053652 (ROGERS, JACK T) Sep 30, 2005 - Aug 31, 2008
    NIH/NINDS
    HTS Molecules Targeting APP 5'untranslated Region(RMI)
    Role: Principal Investigator
  5. R01AG021081 (ROGERS, JACK T) Aug 1, 2003 - Jul 31, 2008
    NIH/NIA
    RNA Therapeutics and Abeta Precursor Protein Translation
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Gao J, Cahill CM, Huang X, Roffman JL, Lamon-Fava S, Fava M, Mischoulon D, Rogers JT. S-Adenosyl Methionine and Transmethylation Pathways in Neuropsychiatric Diseases Throughout Life. Neurotherapeutics. 2018 Jan; 15(1):156-175. PMID: 29340929.
    View in: PubMed
  2. Song N, Wang W, Jia F, Du X, Xie A, He Q, Shen X, Zhang J, Rogers JT, Xie J, Jiang H. Assessments of plasma ghrelin levels in the early stages of parkinson's disease. Mov Disord. 2017 Oct; 32(10):1487-1491. PMID: 28681931.
    View in: PubMed
  3. Meng T, Cao Q, Lei P, Bush AI, Xiang Q, Su Z, He X, Rogers JT, Chiu IM, Zhang Q, Huang Y. Tat-haFGF14-154 Upregulates ADAM10 to Attenuate the Alzheimer Phenotype of APP/PS1 Mice through the PI3K-CREB-IRE1a/XBP1 Pathway. Mol Ther Nucleic Acids. 2017 Jun 16; 7:439-452. PMID: 28624220.
    View in: PubMed
  4. Rogers JT, Venkataramani V, Washburn C, Liu Y, Tummala V, Jiang H, Smith A, Cahill CM. A role for amyloid precursor protein translation to restore iron homeostasis and ameliorate lead (Pb) neurotoxicity. J Neurochem. 2016 08; 138(3):479-94. PMID: 27206843.
    View in: PubMed
  5. Plascencia-Villa G, Ponce A, Collingwood JF, Arellano-Jiménez MJ, Zhu X, Rogers JT, Betancourt I, José-Yacamán M, Perry G. High-resolution analytical imaging and electron holography of magnetite particles in amyloid cores of Alzheimer's disease. Sci Rep. 2016 04 28; 6:24873. PMID: 27121137; PMCID: PMC4848473.
  6. Cahill CM, Zhu W, Oziolor E, Yang YJ, Tam B, Rajanala S, Rogers JT, Walker WA. Differential Expression of the Activator Protein 1 Transcription Factor Regulates Interleukin-1ß Induction of Interleukin 6 in the Developing Enterocyte. PLoS One. 2016; 11(1):e0145184. PMID: 26799482; PMCID: PMC4723075.
  7. Ayton S, Lei P, Hare DJ, Duce JA, George JL, Adlard PA, McLean C, Rogers JT, Cherny RA, Finkelstein DI, Bush AI. Parkinson's disease iron deposition caused by nitric oxide-induced loss of ß-amyloid precursor protein. J Neurosci. 2015 Feb 25; 35(8):3591-7. PMID: 25716857.
    View in: PubMed
  8. Bandyopadhyay S, Rogers JT. Alzheimer's disease therapeutics targeted to the control of amyloid precursor protein translation: maintenance of brain iron homeostasis. Biochem Pharmacol. 2014 Apr 15; 88(4):486-94. PMID: 24513321; PMCID: PMC4064675.
  9. Tao Y, Wang Y, Rogers JT, Wang F. Perturbed iron distribution in Alzheimer's disease serum, cerebrospinal fluid, and selected brain regions: a systematic review and meta-analysis. J Alzheimers Dis. 2014; 42(2):679-90. PMID: 24916541.
    View in: PubMed
  10. Bandyopadhyay S, Cahill C, Balleidier A, Huang C, Lahiri DK, Huang X, Rogers JT. Novel 5' untranslated region directed blockers of iron-regulatory protein-1 dependent amyloid precursor protein translation: implications for down syndrome and Alzheimer's disease. PLoS One. 2013; 8(7):e65978. PMID: 23935819; PMCID: PMC3729844.
  11. Hahl P, Davis T, Washburn C, Rogers JT, Smith A. Mechanisms of neuroprotection by hemopexin: modeling the control of heme and iron homeostasis in brain neurons in inflammatory states. J Neurochem. 2013 Apr; 125(1):89-101. PMID: 23350672; PMCID: PMC3752430.
  12. Lahiri DK, Maloney B, Rogers JT, Ge YW. PuF, an antimetastatic and developmental signaling protein, interacts with the Alzheimer's amyloid-ß precursor protein via a tissue-specific proximal regulatory element (PRE). BMC Genomics. 2013 Jan 31; 14:68. PMID: 23368879; PMCID: PMC3582491.
  13. Hu B, Jiang G, Pang C, Wang S, Liu Q, Chen Z, Vanderburg CR, Rogers JT, Deng Y, Huang X. Assessment of gene order computing methods for Alzheimer's disease. BMC Med Genomics. 2013; 6 Suppl 1:S8. PMID: 23369541; PMCID: PMC3552676.
  14. Yu QS, Reale M, Kamal MA, Holloway HW, Luo W, Sambamurti K, Ray B, Lahiri DK, Rogers JT, Greig NH. Synthesis of the Alzheimer drug Posiphen into its primary metabolic products (+)-N1-norPosiphen, (+)-N8-norPosiphen and (+)-N1, N8-bisnorPosiphen, their inhibition of amyloid precursor protein, a-Synuclein synthesis, interleukin-1ß release, and cholinergic action. Antiinflamm Antiallergy Agents Med Chem. 2013; 12(2):117-28. PMID: 23360256.
    View in: PubMed
  15. Mikkilineni S, Cantuti-Castelvetri I, Cahill CM, Balliedier A, Greig NH, Rogers JT. The anticholinesterase phenserine and its enantiomer posiphen as 5'untranslated-region-directed translation blockers of the Parkinson's alpha synuclein expression. Parkinsons Dis. 2012; 2012:142372. PMID: 22693681; PMCID: PMC3368596.
  16. David Olivares, Varun K. Deshpande, Ying Shi, Debomoy K. Lahiri, Nigel H. Greig, Jack T. Rogers, and Xudong Huang. N-Methyl D-Aspartate (NMDA) Receptor Antagonists and Memantine Treatment for Alzheimer’s Disease, Vascular Dementia and Parkinson’s Disease. Current Alzheimer Research. 2012; 9:1000.
  17. Cahill, CM., Rogers, JT., Walker, A. J. Signal Transduction. The role of phosphoinositide-3-kinase signaling intestinal Inflammation. 2012; ID 358476:1-13.
  18. Duce JA, Ayton S, Miller AA, Tsatsanis A, Lam LQ, Leone L, Corbin JE, Butzkueven H, Kilpatrick TJ, Rogers JT, Barnham KJ, Finkelstein DI, Bush AI. Amine oxidase activity of ß-amyloid precursor protein modulates systemic and local catecholamine levels. Mol Psychiatry. 2013 Feb; 18(2):245-54. PMID: 22212595.
    View in: PubMed
  19. Rogers JT, Mikkilineni S, Cantuti-Castelvetri I, Smith DH, Huang X, Bandyopadhyay S, Cahill CM, Maccecchini ML, Lahiri DK, Greig NH. The alpha-synuclein 5'untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen. J Neural Transm (Vienna). 2011 Mar; 118(3):493-507. PMID: 21221670.
    View in: PubMed
  20. Bandyopadhyay S, Huang X, Lahiri DK, Rogers JT. Novel drug targets based on metallobiology of Alzheimer's disease. Expert Opin Ther Targets. 2010 Nov; 14(11):1177-97. PMID: 20942746.
    View in: PubMed
  21. Duce JA, Tsatsanis A, Cater MA, James SA, Robb E, Wikhe K, Leong SL, Perez K, Johanssen T, Greenough MA, Cho HH, Galatis D, Moir RD, Masters CL, McLean C, Tanzi RE, Cappai R, Barnham KJ, Ciccotosto GD, Rogers JT, Bush AI. Iron-export ferroxidase activity of ß-amyloid precursor protein is inhibited by zinc in Alzheimer's disease. Cell. 2010 Sep 17; 142(6):857-67. PMID: 20817278; PMCID: PMC2943017.
  22. Cho HH, Cahill CM, Vanderburg CR, Scherzer CR, Wang B, Huang X, Rogers JT. Selective translational control of the Alzheimer amyloid precursor protein transcript by iron regulatory protein-1. J Biol Chem. 2010 Oct 08; 285(41):31217-32. PMID: 20558735; PMCID: PMC2951196.
  23. Pang CY, Hu W, Hu BQ, Shi Y, Vanderburg CR, Rogers JT, Huang X. A special local clustering algorithm for identifying the genes associated with Alzheimer's disease. IEEE Trans Nanobioscience. 2010 Mar; 9(1):44-50. PMID: 20089478; PMCID: PMC3008360.
  24. Maloney B, Ge YW, Petersen RC, Hardy J, Rogers JT, Pérez-Tur J, Lahiri DK. Functional characterization of three single-nucleotide polymorphisms present in the human APOE promoter sequence: Differential effects in neuronal cells and on DNA-protein interactions. Am J Med Genet B Neuropsychiatr Genet. 2010 Jan 05; 153B(1):185-201. PMID: 19504470.
    View in: PubMed
  25. Zhao W, Liu Y, Cahill CM, Yang W, Rogers JT, Huang X. The role of T cells in osteoporosis, an update. Int J Clin Exp Pathol. 2009 May 20; 2(6):544-52. PMID: 19636401; PMCID: PMC2713452.
  26. Olivares D, Huang X, Branden L, Greig NH, Rogers JT. Physiological and pathological role of alpha-synuclein in Parkinson's disease through iron mediated oxidative stress; the role of a putative iron-responsive element. Int J Mol Sci. 2009 Mar; 10(3):1226-60. PMID: 19399246; PMCID: PMC2672027.
  27. Kong W, Mou X, Liu Q, Chen Z, Vanderburg CR, Rogers JT, Huang X. Independent component analysis of Alzheimer's DNA microarray gene expression data. Mol Neurodegener. 2009 Jan 28; 4:5. PMID: 19173745.
    View in: PubMed
  28. Cahill CM, Lahiri DK, Huang X, Rogers JT. Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases. Biochim Biophys Acta. 2009 Jul; 1790(7):615-28. PMID: 19166904; PMCID: PMC3981543.
  29. Rogers JT, Bush AI, Cho HH, Smith DH, Thomson AM, Friedlich AL, Lahiri DK, Leedman PJ, Huang X, Cahill CM. Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease. Biochem Soc Trans. 2008 Dec; 36(Pt 6):1282-7. PMID: 19021541; PMCID: PMC2746665.
  30. Kong W, Vanderburg CR, Gunshin H, Rogers JT, Huang X. A review of independent component analysis application to microarray gene expression data. Biotechniques. 2008 Nov; 45(5):501-20. PMID: 19007336; PMCID: PMC3005719.
  31. Yi J, Horky LL, Friedlich AL, Shi Y, Rogers JT, Huang X. L-arginine and Alzheimer's disease. Int J Clin Exp Pathol. 2009; 2(3):211-38. PMID: 19079617; PMCID: PMC2600464.
  32. Qureshi M, Brown RH, Rogers JT, Cudkowicz ME. Serum ferritin and metal levels as risk factors for amyotrophic lateral sclerosis. Open Neurol J. 2008 Sep 12; 2:51-4. PMID: 19452011; PMCID: PMC2627516.
  33. Patel N, Hoang D, Miller N, Ansaloni S, Huang Q, Rogers JT, Lee JC, Saunders AJ. MicroRNAs can regulate human APP levels. Mol Neurodegener. 2008 Aug 06; 3:10. PMID: 18684319; PMCID: PMC2529281.
  34. James A. Duce, Jack T. Rogers, Andrew Tsatsanis, Robert D. Moir, Elysia Robb, Su Ling Leong, Susan M. Harding, Amanda Venti, Colin Masters, Roberto Cappai, Rudolph E. Tanzi, Ashley I. Bush. Alzheimer's Disease ß-Amyloid Protein Precursor Is Ferroxidase II, a Ceruloplasmin-like Iron Detoxification Enzyme. Alzheimer Asociation Meeting, Washington DC. 2008.
  35. Cahill CM, Rogers JT. Interleukin (IL) 1beta induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT/IkappaB kinase alpha pathway targeting activator protein-1. J Biol Chem. 2008 Sep 19; 283(38):25900-12. PMID: 18515365; PMCID: PMC2533786.
  36. Avi Friedlich, Hyun-Hee Cho, Rudolph Tanzi, Robert Moir, Ashley Bush, Xudong Huang, Jack Rogers. An Iron-Responsive Element in the Alpha Synuclein Transcript (Awarded First Prize). Myselle Harvard-wide Psychiatry Research Symposium. 2008.
  37. Patel AK, Rogers JT, Huang X. Flavanols, mild cognitive impairment, and Alzheimer's dementia. Int J Clin Exp Med. 2008; 1(2):181-91. PMID: 19079672; PMCID: PMC2596318.
  38. Chen J, Zhu J, Cho H-H, Cui K, Li F, Zhou X, Rogers JT, Huang X., Wong STC . Differential cytotoxicity of metal oxide nanoparticles. Journal of Experimental Nanoscience. 2008; Accepted and In Press.
  39. Hyun-Hee Cho, Marcie Glicksman, Juliet Moncaster, Lee Goldstein2, Ashley Bush, Catherine Cahill, Xudong Huang, Jack Rogers. . Iron-responsive Translational Control of the Amyloid Precursor Protein, Novel Ferroxidase Activity of Its Secreted fragments, and Its 5’UTR as a Therapeutic Target for Alzheimer's Disease. . Journal of Trace Metals. 2007.
  40. Friedlich AL, Tanzi RE, Rogers JT. The 5'-untranslated region of Parkinson's disease alpha-synuclein messengerRNA contains a predicted iron responsive element. Mol Psychiatry. 2007 Mar; 12(3):222-3. PMID: 17325711.
    View in: PubMed
  41. Bandyopadhyay S, Goldstein LE, Lahiri DK, Rogers JT. Role of the APP non-amyloidogenic signaling pathway and targeting alpha-secretase as an alternative drug target for treatment of Alzheimer's disease. Curr Med Chem. 2007; 14(27):2848-64. PMID: 18045131.
    View in: PubMed
  42. Lahiri DK, Ge YW, Rogers JT, Sambamurti K, Greig NH, Maloney B. Taking down the unindicted co-conspirators of amyloid beta-peptide-mediated neuronal death: shared gene regulation of BACE1 and APP genes interacting with CREB, Fe65 and YY1 transcription factors. Curr Alzheimer Res. 2006 Dec; 3(5):475-83. PMID: 17168646.
    View in: PubMed
  43. Bandyopadhyay S, Hartley DM, Cahill CM, Lahiri DK, Chattopadhyay N, Rogers JT. Interleukin-1alpha stimulates non-amyloidogenic pathway by alpha-secretase (ADAM-10 and ADAM-17) cleavage of APP in human astrocytic cells involving p38 MAP kinase. J Neurosci Res. 2006 Jul; 84(1):106-18. PMID: 16724341.
    View in: PubMed
  44. Andrew Tsatsanis, Michael Cater, Stephanie Tucker, Robert D. Moir, Rudolph E. Tanzi, Jack T. Rogers, Ashley I. Bush. Endogenous human APP possesses oxidase activity. Neurobiology of Aging (Alzheimer's Association International Meeting in Madrid, Spain). 2006.
  45. Tucker S, Ahl M, Cho HH, Bandyopadhyay S, Cuny GD, Bush AI, Goldstein LE, Westaway D, Huang X, Rogers JT. RNA therapeutics directed to the non coding regions of APP mRNA, in vivo anti-amyloid efficacy of paroxetine, erythromycin, and N-acetyl cysteine. Curr Alzheimer Res. 2006 Jul; 3(3):221-7. PMID: 16842099.
    View in: PubMed
  46. Bandyopadhyay S, Ni J, Ruggiero A, Walshe K, Rogers MS, Chattopadhyay N, Glicksman MA, Rogers JT. A high-throughput drug screen targeted to the 5'untranslated region of Alzheimer amyloid precursor protein mRNA. J Biomol Screen. 2006 Aug; 11(5):469-80. PMID: 16928984.
    View in: PubMed
  47. Liu G, Huang W, Moir RD, Vanderburg CR, Lai B, Peng Z, Tanzi RE, Rogers JT, Huang X. Metal exposure and Alzheimer's pathogenesis. J Struct Biol. 2006 Jul; 155(1):45-51. PMID: 16503166.
    View in: PubMed
  48. Bandyopadhyay S, Huang X, Cho H, Greig NH, Youdim MB, Rogers JT. Metal specificity of an iron-responsive element in Alzheimer's APP mRNA 5'untranslated region, tolerance of SH-SY5Y and H4 neural cells to desferrioxamine, clioquinol, VK-28, and a piperazine chelator. J Neural Transm Suppl. 2006; (71):237-47. PMID: 17447434.
    View in: PubMed
  49. Rogers JT. . PEPTIDES DERIVED FROM THE HUMAN AMYLOID PRECURSOR PROTEIN. 2005.
  50. Rogers, JT. APP and Ferritin Translation, Metals and Alzheimer's Disease. Sessler, J, editor. Metals in Medicine, J. Am. Chem Soc. 2005; 215-251.
  51. Thomson AM, Cahill CM, Cho HH, Kassachau KD, Epis MR, Bridges KR, Leedman PJ, Rogers JT. The acute box cis-element in human heavy ferritin mRNA 5'-untranslated region is a unique translation enhancer that binds poly(C)-binding proteins. J Biol Chem. 2005 Aug 26; 280(34):30032-45. PMID: 15967798.
    View in: PubMed
  52. Tucker S, Ahl M, Bush A, Westaway D, Huang X, Rogers JT. Pilot study of the reducing effect on amyloidosis in vivo by three FDA pre-approved drugs via the Alzheimer's APP 5' untranslated region. Curr Alzheimer Res. 2005 Apr; 2(2):249-54. PMID: 15974925.
    View in: PubMed
  53. Rogers, JT., Greig, N.H., Lahiri, DK., Fisher, A. Translation and Processing of the Amyloid Precursor Protein in response to an M1 muscaric agonist and an acetyl cholinesterase inhibitor. Therapeutic strategies in Neurodegenerative Diseases. Fisher, A and Hanin, I, eds. 2005; 35:265-278.
  54. Greig NH, Mattson MP, Perry T, Chan SL, Giordano T, Sambamurti K, Rogers JT, Ovadia H, Lahiri DK. New therapeutic strategies and drug candidates for neurodegenerative diseases: p53 and TNF-alpha inhibitors, and GLP-1 receptor agonists. Ann N Y Acad Sci. 2004 Dec; 1035:290-315. PMID: 15681814.
    View in: PubMed
  55. Lahiri DK, Chen D, Lahiri P, Rogers JT, Greig NH, Bondy S. Melatonin, metals, and gene expression: implications in aging and neurodegenerative disorders. Ann N Y Acad Sci. 2004 Dec; 1035:216-30. PMID: 15681810.
    View in: PubMed
  56. Venti A, Giordano T, Eder P, Bush AI, Lahiri DK, Greig NH, Rogers JT. The integrated role of desferrioxamine and phenserine targeted to an iron-responsive element in the APP-mRNA 5'-untranslated region. Ann N Y Acad Sci. 2004 Dec; 1035:34-48. PMID: 15681799.
    View in: PubMed
  57. Dedeoglu A, Cormier K, Payton S, Tseitlin KA, Kremsky JN, Lai L, Li X, Moir RD, Tanzi RE, Bush AI, Kowall NW, Rogers JT, Huang X. Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis. Exp Gerontol. 2004 Nov-Dec; 39(11-12):1641-9. PMID: 15582280.
    View in: PubMed
  58. Rogers JT, Lahiri DK. Metal and inflammatory targets for Alzheimer's disease. Curr Drug Targets. 2004 Aug; 5(6):535-51. PMID: 15270200.
    View in: PubMed
  59. Payton, S and Rogers, JT. Drug Discovery for Alzheimer's Disease Targeted to the APP 5'untranslated region. Harvard University Research Day (Mysell Research Colloquium). 2004.
  60. Huang X, Moir RD, Tanzi RE, Bush AI, Rogers JT. Redox-active metals, oxidative stress, and Alzheimer's disease pathology. Ann N Y Acad Sci. 2004 Mar; 1012:153-63. PMID: 15105262.
    View in: PubMed
  61. Morse LJ, Payton SM, Cuny GD, Rogers JT. FDA-preapproved drugs targeted to the translational regulation and processing of the amyloid precursor protein. J Mol Neurosci. 2004; 24(1):129-36. PMID: 15314261.
    View in: PubMed
  62. Venti, A., Giordano, T., Eder, P., Bush, A., Lahiri, DK., Greig, N., Rogers, JT. Integrated role of desferrioxamine and phenserine Targeted to the Iron Responsive Element in the 5'UTR of the APP transcript. Ann NY. Acad. Sci. 2004; 1035:34-48.
  63. Jack T. Rogers, Stephanie Tucker, Sandra Payton, Nigel H. Greig, Rick Jensen, Greg Cuny, Debomoy K. Lahiri, Lee Jae Morse, Rudolph E. Tanzi, David Westaway, Ashley Bush, Steve Gullans, Satinder Sarang, Xudong Huang . Alzheimer's disease drug discovery targeted to the APP mRNA 5' untranslated region: a validated target. Neurobiology of Aging, AD meeting in Philadelphia. 2004.
  64. Lahiri DK, Rogers JT, Greig NH, Sambamurti K. Rationale for the development of cholinesterase inhibitors as anti-Alzheimer agents. Curr Pharm Des. 2004; 10(25):3111-9. PMID: 15544501.
    View in: PubMed
  65. NH. Greig, MP. Mattson, TA Perry, S Chan, T Giordano, K Sambamurti, J Rogers, H Ovadia, DK. Lahiri. New Therapeutic Strategies And Drug Candidates For Neurodegenerative Diseases. Ann NY Acad Sci. 2004; 1035:290-315.
  66. 17. Lahiri DK, Chen D, Lahiri P, Rogers JT, Greig NH, Bondy S. . Melatonin, Metals And Gene Expression: Implications In Aging And Neurodegenerative Disorders. Ann NY Acad Sci. 2004; 1035:216-30..
  67. Huang, X., Moir, RD., Tanzi, RD., Bush, AI., Rogers, JT. Redox-active Metals, Oxidative Stress, and Alzheimer's Disease Pathology. Ann. NY. Acad. Sci. 2004; 1012:153-163.
  68. Jack T. Rogers, Lee Jae Morse, Michael Lombardi, Patrick Devaney, Roderick Jensen. Metallothionein 3 gene expression is up-regulated by intracellular iron chelation, the role of a putative Iron-responsive Element in the 3’untranslated region. Neurobiology of Aging, AD meeting in Philadelphia, PA. 2004.
  69. Greig NH, Giordano T, Zhu X, Yu QS, Perry TA, Holloway HW, Brossi A, Rogers JT, Sambamurti K, Lahiri DK. Thalidomide-based TNF-alpha inhibitors for neurodegenerative diseases. Acta Neurobiol Exp (Wars). 2004; 64(1):1-9. PMID: 15190675.
    View in: PubMed
  70. Avi Friedlich and Jack T. Rogers. TRANSLATION ENHANCER ELEMENTS OF THE GENE ENCODING THE HUMAN MICROTUBULE ASSOCIATED PROTEIN TAU. 2003.
  71. Rogers JT. Avi Friedlich. . TRANSLATION ENHANCER ELEMENT OF THE GENE ENCODING THE HUMAN ALPHA-SYNUCLEIN PROTEIN. 2003.
  72. Rogers JT. Payton, S., Gullans, S., Randall, J., Sarang, S Patent pending. METHODS AND COMPOSITIONS FOR MODULATING AMYLOID PRECURSOR PROTEIN TRANSLATION. 2003.
  73. Lahiri DK, Chen D, Vivien D, Ge YW, Greig NH, Rogers JT. Role of cytokines in the gene expression of amyloid beta-protein precursor: identification of a 5'-UTR-binding nuclear factor and its implications in Alzheimer's disease. J Alzheimers Dis. 2003 Apr; 5(2):81-90. PMID: 12719626.
    View in: PubMed
  74. Payton S, Cahill CM, Randall JD, Gullans SR, Rogers JT. Drug discovery targeted to the Alzheimer's APP mRNA 5'-untranslated region: the action of paroxetine and dimercaptopropanol. J Mol Neurosci. 2003; 20(3):267-75. PMID: 14501007.
    View in: PubMed
  75. Rogers, JT., Payton, S., Greig, N., Lahiri, DK., Fisher A. . An M1 muscarinic agonist and an acetylcholinesterase inhibitor alter translation and processing of the Amyloid Proecursor Protein (APP). AD/PD conference, Seville Spain. 2003.
  76. Friedlich, A, Huang, X., Nagano, S., Rogers, JT., Goldstein, L., Bush., AI., Multhaup, G., Beyreuther, K., Stremmel, W., Bayer, T . Importance of copper and zinc in Alzheimer’s disease and the biology of the beta amyloid protein and amyloid precursor protein. Metal Ions and Neurodegenerative Disease. 2003.
  77. Rogers JT, Randall JD, Cahill CM, Eder PS, Huang X, Gunshin H, Leiter L, McPhee J, Sarang SS, Utsuki T, Greig NH, Lahiri DK, Tanzi RE, Bush AI, Giordano T, Gullans SR. An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript. J Biol Chem. 2002 Nov 22; 277(47):45518-28. PMID: 12198135.
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  78. Rogers JT, Randall JD, Eder PS, Huang X, Bush AI, Tanzi RE, Venti A, Payton SM, Giordano T, Nagano S, Cahill CM, Moir R, Lahiri DK, Greig N, Sarang SS, Gullans SR. Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated region. J Mol Neurosci. 2002 Aug-Oct; 19(1-2):77-82. PMID: 12212798.
    View in: PubMed
  79. Rogers, JT et al. Ferroxidase activity in APP(s)). Neurobiology of Aging, AD Meeting in Stockholm, Sweden. 2002; 23(15):5 S509 .
  80. Rogers,JT., Huang, X., Bush, AI . Therapeutic Targets for Alzheimer's Disease. Neuroprotection, Eng. Lo and Joseph Martwah, Eds. 2002.
  81. Rogers, JT. et al. . APP 5’UTR RNA targeting as a therapeutic strategy for Alzheimer's Disease. Neurobiology of Aging, AD meeting in Stockholm, Sweden. 2002; 23(15):S79.
  82. Gunshin H, Allerson CR, Polycarpou-Schwarz M, Rofts A, Rogers JT, Kishi F, Hentze MW, Rouault TA, Andrews NC, Hediger MA. Iron-dependent regulation of the divalent metal ion transporter. FEBS Lett. 2001 Dec 07; 509(2):309-16. PMID: 11741608.
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  83. Rogers, JT. . TRANSLATION ENHANCER ELEMENT OF THE HUMAN AMYLOID PRECURSOR PROTEIN GENE. 2001.
  84. Rogers JT. . Targeting an RNA structure in the Alzheimer's amyloid precursor protein gene as a new therapeutic strategy for Alzheimer's disease. H Fillit and Alan O’Connell, Eds. 2001; 74-88.
  85. D.K. Lahiri, T. Utsuki, K.T.Y. Shaw, Y.-W. Ge, K. Sambamurti, P.S. Eder, J. T. Rogers, M.R. Farlow, T. Giordino, N.H. Greig. (2001). . Pheserine regulates translation of the beta-amyloid precursor protein message. Mapping the Progress of Alzheimer's and Parkinson's Disease, Yoshikuni Mizuno, Abraham Fisher, Israel Hanin (Eds). 2001.
  86. Shaw, KTT., Utsuki, T., Rogers, JT., Yu, Q-S., Grieg, NH. Translational regulation of Alzheimer's beta-amyloid Precursor Protein mRNA by a putative interleukin-1 responsive element, a new target for drug development. Proc Natl Acad Sci USA. 2001; 98:7605-7610.
  87. Thomson AM, Rogers JT, Leedman PJ. Thyrotropin-releasing hormone and epidermal growth factor regulate iron-regulatory protein binding in pituitary cells via protein kinase C-dependent and -independent signaling pathways. J Biol Chem. 2000 Oct 13; 275(41):31609-15. PMID: 10889193.
    View in: PubMed
  88. Bush AI, Atwood CS, Goldstein LE, Huang X, Rogers J. Could Abeta and AbetaPP be Antioxidants? J Alzheimers Dis. 2000 Jun; 2(2):83-84. PMID: 12214093.
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  89. Rogers, JT., Moir, RD., Huang, X., Venti, A., Sarhan, N., Van Nostrand, WE., Tanzi, R., Bush, AI. Intrinsic Ferroxidase activity in the Alzheimer's Amyloid Precursor Protein. Neurobiology of Aging, AD meeting in Washington, DC. 2000; 21:S261.
  90. Thomson AM, Rogers JT, Walker CE, Staton JM, Leedman PJ. Optimized RNA gel-shift and UV cross-linking assays for characterization of cytoplasmic RNA-protein interactions. Biotechniques. 1999 Nov; 27(5):1032-9, 1042. PMID: 10572651.
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  91. Thomson AM, Rogers JT, Leedman PJ. Iron-regulatory proteins, iron-responsive elements and ferritin mRNA translation. Int J Biochem Cell Biol. 1999 Oct; 31(10):1139-52. PMID: 10582343.
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  92. Rogers JT, Leiter LM, McPhee J, Cahill CM, Zhan SS, Potter H, Nilsson LN. Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences. J Biol Chem. 1999 Mar 05; 274(10):6421-31. PMID: 10037734.
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  93. Toth I, Yuan L, Rogers JT, Boyce H, Bridges KR. Hypoxia alters iron-regulatory protein-1 binding capacity and modulates cellular iron homeostasis in human hepatoma and erythroleukemia cells. J Biol Chem. 1999 Feb 12; 274(7):4467-73. PMID: 9933651.
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  94. Cahill CM, Rogers JT. Anti-idiotypic sera against monoclonal anti-porcine growth hormone antibodies: production in rabbits and characterization of specificity. J Immunoassay. 1999 Feb-May; 20(1-2):45-55. PMID: 10225514.
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  95. Rogers, JT. Gunshin, H. Andrews, I Toth, L Leiter, X Huang, R.L Nilsson, K Bridges, H Potter, N Andrews D. Selkoe, R Tanzi, A Bush. Translational control of the Alzheimer's Amyloid Precursor Protein. Abstract/paper submitted to the conference on Aging, American Federation of Aging Research (AFAR), Philadelphia. May 1999). 1999.
  96. Rogers, JT, Potter, H., Nilsson, L . Amyloid Precursor Protein gene regulation at the translational level by Interleukin-1 and iron. Society for Neuroscience 29th Annual meeting in Miami. 1999.
  97. Venti, A., Moir, R., Bridges, KR., Tanzi, RE., Bush, AI., Rogers, JT. . The amino terminus of secreted APP exhibits ferroxidase activity. American Society for Cell Biology Congress in Washington DC. 1999.
  98. Nilsson, L., Rogers, JT., Potter, H. The essential role of inflammation and induced gene expression in the pathogenic pathway of Alzheimer's disease. Frontiers in Bioscience. 1998; 3:436-446.
  99. Rogers, JT., Nilsson, L., McPhee, J., Zhan, SS., Potter, H., Leiter, L. . Translational Regulation of the Amyloid Precursor Protein mRNA by Interleukin 1. Society for Neuroscience, Session on Degenerative Diseases: Alzheimer's - Beta Amyloid, Neuroscience meeting in New Orleans. 1997; Abstr: 332.8..
  100. Leedman PJ, Stein AR, Chin WW, Rogers JT. Thyroid hormone modulates the interaction between iron regulatory proteins and the ferritin mRNA iron-responsive element. J Biol Chem. 1996 May 17; 271(20):12017-23. PMID: 8662626.
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  101. Rogers JT. Ferritin translation by interleukin-1and interleukin-6: the role of sequences upstream of the start codons of the heavy and light subunit genes. Blood. 1996 Mar 15; 87(6):2525-37. PMID: 8630420.
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  102. Toth I, Rogers JT, McPhee JA, Elliott SM, Abramson SL, Bridges KR. Ascorbic acid enhances iron-induced ferritin translation in human leukemia and hepatoma cells. J Biol Chem. 1995 Feb 10; 270(6):2846-52. PMID: 7852359.
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  103. Rogers JT, Andriotakis JL, Lacroix L, Durmowicz GP, Kasschau KD, Bridges KR. Translational enhancement of H-ferritin mRNA by interleukin-1 beta acts through 5' leader sequences distinct from the iron responsive element. Nucleic Acids Res. 1994 Jul 11; 22(13):2678-86. PMID: 8041631; PMCID: PMC308227.
  104. Rogers J, Lacroix, L., Durmowicz, G., Kasshau, K., Andriotakis J., Bridges, KR. . Role of cytokines in the regulation of ferritin gene expression. Adv. Exp. Med. Biol. 1994; 356:127-32.
  105. Steel DM, Rogers JT, DeBeer MC, DeBeer FC, Whitehead AS. Biosynthesis of human acute-phase serum amyloid A protein (A-SAA) in vitro: the roles of mRNA accumulation, poly(A) tail shortening and translational efficiency. Biochem J. 1993 May 01; 291 ( Pt 3):701-7. PMID: 8387777; PMCID: PMC1132425.
  106. Rogers JT . Genetic Regulation of the Iron Transport and Storage Genes: Links with the Acute Phase Response. Lauffer R editor, Iron and Human Diseases. CRC Press, Boca Raton, 77-104. 1992 .
  107. Rogers JT, Bridges KR, Durmowicz GP, Glass J, Auron PE, Munro HN. Translational control during the acute phase response. Ferritin synthesis in response to interleukin-1. J Biol Chem. 1990 Aug 25; 265(24):14572-8. PMID: 1696948.
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  108. Munro HN, Leibold EA, Aziz N, Murray MT, White K, Rogers JT . Ferritin Gene Structure and Expression. Ponka P, Schulman HM, Woodworth R, editors, Iron transport and storage, CRC Press, Boca Raton, 133-48. 1990; In: Ponka P, Schulman HM, Wo.
  109. Munro HN, Aziz N, Leibold EA, Murray M, Rogers J, Vass JK, White K. The ferritin genes: structure, expression, and regulation. Ann N Y Acad Sci. 1988; 526:113-23. PMID: 3291676.
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  110. Rogers J, Munro HN. Translation of ferritin light and heavy subunits mRNAs is regulated by intracellular chelatable iron levels in rat hepatoma cells. Proc Natl Acad Sci USA. 1987; 84:2277-81.
  111. Coutelle C, Speer A, Rogers J, Kalsheker N, Humphries S, Williamson R. Construction and partial characterization of a human liver cDNA library. Biomed Biochim Acta. 1985; 44(3):421-31. PMID: 3873938.
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  112. Munro HN, Leibold EA, Vass JK, Aziz N, Rogers JT, Murray M, White K. . Ferritin gene structure and expression. Spik G, Montreuil J, Crighton RR, Mazurier J, editors. Proteins of Iron Storage and Transport. Proceedings of the VIIth International Conference on Proteins of Iron,. 1985; In: Spik G, Montreuil J, Crigh: 331-41.
  113. Myklebost O, Williamson B, Markham AF, Myklebost SR, Rogers J, Woods DE, Humphries SE. The isolation and characterization of cDNA clones for human apolipoprotein CII. J Biol Chem. 1984 Apr 10; 259(7):4401-4. PMID: 6546757.
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  114. Jack T. Rogers. Use of oligonucleotide screening techniques to identify the human alpha-1 antitrypsin and apolipoprotein CII genes. 1984.
  115. Rogers JT, Kalsheker N, Wallis S, Speer A, Coutelle C, Woods D, Humphries,SE. . The isolation of human alpha1-antitrypsin inhibitor cDNA clones. Biochem Biophys Res Commun. 1983; 116:375-8.
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