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Harald Paganetti, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA229178 (PAGANETTI, HARALD) Apr 1, 2019 - Mar 31, 2024
    NIH/NCI
    Fast Individualized Delivery Adaptation in Proton Therapy
    Role: Principal Investigator
  2. R01CA140735 (PAGANETTI, HARALD) Jul 1, 2009 - Jun 30, 2016
    NIH/NCI
    TOPAS: Fast and easy to use Monte Carlo system for proton therapy
    Role: Principal Investigator
  3. R01CA111590 (PAGANETTI, HARALD) Dec 1, 2004 - Apr 30, 2015
    NIH/NCI
    Four-dimensional Monte Carlo dose calculation
    Role: Principal Investigator
  4. U19CA021239 (HONG, THEODORE S) Apr 1, 1997 - Aug 31, 2019
    NIH/NCI
    Improving the Clinical Effectiveness and Understanding of the Biophysical Basis
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gjesteby L, Shan H, Yang Q, Xi Y, Jin Y, Giantsoudi D, Paganetti H, De Man B, Wang G. A dual-stream deep convolutional network for reducing metal streak artifacts in CT images. Phys Med Biol. 2019 11 26; 64(23):235003. PMID: 31618724.
    Citations:    
  2. McNamara A, Willers H, Paganetti H. Modelling variable proton relative biological effectiveness for treatment planning. Br J Radiol. 2020 Mar; 93(1107):20190334. PMID: 31738081.
    Citations:    
  3. Marteinsdottir M, Schuemann J, Paganetti H. Impact of uncertainties in range and RBE on small field proton therapy. Phys Med Biol. 2019 10 10; 64(20):205005. PMID: 31519016.
    Citations:    
  4. Niyazi M, Niemierko A, Paganetti H, Söhn M, Schapira E, Goldberg S, Adams J, Kim V, Oh KS, Hwang WL, Lu HM, Belka C, Busse PM, Loeffler JS, Shih HA. Volumetric and actuarial analysis of brain necrosis in proton therapy using a novel mixture cure model. Radiother Oncol. 2020 Jan; 142:154-161. PMID: 31563411.
    Citations:    
  5. Abhyankar YS, Dev S, Sarun OS, Saxena A, Joshi R, Darbari H, Sajish C, Sonavane UB, Gavane V, Deshpande A, Dixit T, Harsh R, Badwe R, Rath GK, Laskar S, Faddegon B, Perl J, Paganetti H, Schuemann J, Srivastava A, Obcemea C, Nath AK, Sharma A, Buchsbaum J. Monte Carlo Processing on a Chip (MCoaC)-preliminary experiments toward the realization of optimal-hardware for TOPAS/Geant4 to drive discovery. Phys Med. 2019 Aug; 64:166-173. PMID: 31515016.
    Citations:    
  6. Zhu H, Chen Y, Sung W, McNamara AL, Tran LT, Burigo LN, Rosenfeld AB, Li J, Faddegon B, Schuemann J, Paganetti H. The microdosimetric extension in TOPAS: development and comparison with published data. Phys Med Biol. 2019 07 11; 64(14):145004. PMID: 31117056.
    Citations:    
  7. Meschini G, Seregni M, Molinelli S, Vai A, Phillips J, Sharp GC, Pella A, Valvo F, Ciocca M, Riboldi M, Paganetti H, Baroni G. Validation of a model for physical dose variations in irregularly moving targets treated with carbon ion beams. Med Phys. 2019 Aug; 46(8):3663-3673. PMID: 31206718.
    Citations:    
  8. Marteinsdottir M, Paganetti H. Applying a variable relative biological effectiveness (RBE) might affect the analysis of clinical trials comparing photon and proton therapy for prostate cancer. Phys Med Biol. 2019 06 05; 64(11):115027. PMID: 31082810.
    Citations:    
  9. Grassberger C, McClatchy D, Geng C, Kamran SC, Fintelmann F, Maruvka YE, Piotrowska Z, Willers H, Sequist LV, Hata AN, Paganetti H. Patient-Specific Tumor Growth Trajectories Determine Persistent and Resistant Cancer Cell Populations during Treatment with Targeted Therapies. Cancer Res. 2019 Jul 15; 79(14):3776-3788. PMID: 31113818.
    Citations:    
  10. Newpower M, Schuemann J, Mohan R, Paganetti H, Titt U. Comparing 2 Monte Carlo Systems in Use for Proton Therapy Research. Int J Part Ther. 2019; 6(1):18-27. PMID: 31773045.
    Citations:    
  11. Oesten H, Neubeck CV, Jakob A, Enghardt W, Krause M, McMahon SJ, Grassberger C, Paganetti H, Lühr A. Predicting In Vitro Cancer Cell Survival Based on Measurable Cell Characteristics. Radiat Res. 2019 06; 191(6):532-544. PMID: 31008688.
    Citations:    
  12. Li Y, Dykstra M, Best TD, Pursley J, Chopra N, Keane FK, Khandekar MJ, Sharp GC, Paganetti H, Willers H, Fintelmann FJ, Grassberger C. Differential inflammatory response dynamics in normal lung following stereotactic body radiation therapy with protons versus photons. Radiother Oncol. 2019 07; 136:169-175. PMID: 31015121.
    Citations:    
  13. Paganetti H, Blakely E, Carabe-Fernandez A, Carlson DJ, Das IJ, Dong L, Grosshans D, Held KD, Mohan R, Moiseenko V, Niemierko A, Stewart RD, Willers H. Report of the AAPM TG-256 on the relative biological effectiveness of proton beams in radiation therapy. Med Phys. 2019 Mar; 46(3):e53-e78. PMID: 30661238.
    Citations:    Fields:    
  14. Schuemann J, McNamara AL, Ramos-Méndez J, Perl J, Held KD, Paganetti H, Incerti S, Faddegon B. TOPAS-nBio: An Extension to the TOPAS Simulation Toolkit for Cellular and Sub-cellular Radiobiology. Radiat Res. 2019 02; 191(2):125-138. PMID: 30609382.
    Citations:    Fields:    
  15. Durante M, Paganetti H, Pompos A, Kry SF, Wu X, Grosshans DR. Report of a National Cancer Institute special panel: Characterization of the physical parameters of particle beams for biological research. Med Phys. 2019 Feb; 46(2):e37-e52. PMID: 30506898.
    Citations:    Fields:    
  16. Botas P, Kim J, Winey B, Paganetti H. Online adaption approaches for intensity modulated proton therapy for head and neck patients based on cone beam CTs and Monte Carlo simulations. Phys Med Biol. 2018 12 19; 64(1):015004. PMID: 30524097.
    Citations:    Fields:    
  17. McMahon SJ, Paganetti H, Prise KM. LET-weighted doses effectively reduce biological variability in proton radiotherapy planning. Phys Med Biol. 2018 11 09; 63(22):225009. PMID: 30412471.
    Citations:    Fields:    
  18. Schuemann J, McNamara AL, Warmenhoven JW, Henthorn NT, Kirkby KJ, Merchant MJ, Ingram S, Paganetti H, Held KD, Ramos-Mendez J, Faddegon B, Perl J, Goodhead DT, Plante I, Rabus H, Nettelbeck H, Friedland W, Kundrát P, Ottolenghi A, Baiocco G, Barbieri S, Dingfelder M, Incerti S, Villagrasa C, Bueno M, Bernal MA, Guatelli S, Sakata D, Brown JMC, Francis Z, Kyriakou I, Lampe N, Ballarini F, Carante MP, Davídková M, Štepán V, Jia X, Cucinotta FA, Schulte R, Stewart RD, Carlson DJ, Galer S, Kuncic Z, Lacombe S, Milligan J, Cho SH, Sawakuchi G, Inaniwa T, Sato T, Li W, Solov'yov AV, Surdutovich E, Durante M, Prise KM, McMahon SJ. A New Standard DNA Damage (SDD) Data Format. Radiat Res. 2019 01; 191(1):76-92. PMID: 30407901.
    Citations:    Fields:    
  19. Tucker SL, Xu T, Paganetti H, Deist T, Verma V, Choi N, Mohan R, Liao Z. Validation of Effective Dose as a Better Predictor of Radiation Pneumonitis Risk Than Mean Lung Dose: Secondary Analysis of a Randomized Trial. Int J Radiat Oncol Biol Phys. 2019 02 01; 103(2):403-410. PMID: 30291994.
    Citations:    Fields:    
  20. Paganetti H. Proton Relative Biological Effectiveness - Uncertainties and Opportunities. Int J Part Ther. 2018; 5(1):2-14. PMID: 30370315.
    Citations:    
  21. Chen Y, Grassberger C, Li J, Hong TS, Paganetti H. Impact of potentially variable RBE in liver proton therapy. Phys Med Biol. 2018 09 21; 63(19):195001. PMID: 30183674.
    Citations:    Fields:    
  22. McNamara AL, Ramos-Méndez J, Perl J, Held K, Dominguez N, Moreno E, Henthorn NT, Kirkby KJ, Meylan S, Villagrasa C, Incerti S, Faddegon B, Paganetti H, Schuemann J. Geometrical structures for radiation biology research as implemented in the TOPAS-nBio toolkit. Phys Med Biol. 2018 09 06; 63(17):175018. PMID: 30088810.
    Citations:    Fields:    
  23. Geng C, Paganetti H, Grassberger C. Author Correction: Prediction of Treatment Response for Combined Chemo- and Radiation Therapy for Non-Small Cell Lung Cancer Patients Using a Bio-Mathematical Model. Sci Rep. 2018 Aug 17; 8(1):12631. PMID: 30115991.
    Citations:    Fields:    
  24. Paganetti H, Giantsoudi D. Relative Biological Effectiveness Uncertainties and Implications for Beam Arrangements and Dose Constraints in Proton Therapy. Semin Radiat Oncol. 2018 06; 28(3):256-263. PMID: 29933885.
    Citations:    Fields:    Translation:HumansCells
  25. Ramos-Méndez J, Perl J, Schuemann J, McNamara A, Paganetti H, Faddegon B. Monte Carlo simulation of chemistry following radiolysis with TOPAS-nBio. Phys Med Biol. 2018 05 17; 63(10):105014. PMID: 29697057.
    Citations: 1     Fields:    
  26. Giantsoudi D, Adams J, MacDonald S, Paganetti H. Can differences in linear energy transfer and thus relative biological effectiveness compromise the dosimetric advantage of intensity-modulated proton therapy as compared to passively scattered proton therapy? Acta Oncol. 2018 Sep; 57(9):1259-1264. PMID: 29726722.
    Citations:    Fields:    Translation:HumansCellsCTClinical Trials
  27. Haas-Kogan D, Indelicato D, Paganetti H, Esiashvili N, Mahajan A, Yock T, Flampouri S, MacDonald S, Fouladi M, Stephen K, Kalapurakal J, Terezakis S, Kooy H, Grosshans D, Makrigiorgos M, Mishra K, Poussaint TY, Cohen K, Fitzgerald T, Gondi V, Liu A, Michalski J, Mirkovic D, Mohan R, Perkins S, Wong K, Vikram B, Buchsbaum J, Kun L. National Cancer Institute Workshop on Proton Therapy for Children: Considerations Regarding Brainstem Injury. Int J Radiat Oncol Biol Phys. 2018 05 01; 101(1):152-168. PMID: 29619963.
    Citations:    Fields:    
  28. Underwood TSA, Grassberger C, Bass R, MacDonald SM, Meyersohn NM, Yeap BY, Jimenez RB, Paganetti H. Asymptomatic Late-phase Radiographic Changes Among Chest-Wall Patients Are Associated With a Proton RBE Exceeding 1.1. Int J Radiat Oncol Biol Phys. 2018 07 15; 101(4):809-819. PMID: 29976493.
    Citations:    Fields:    
  29. Unkelbach J, Paganetti H. Robust Proton Treatment Planning: Physical and Biological Optimization. Semin Radiat Oncol. 2018 04; 28(2):88-96. PMID: 29735195.
    Citations: 1     Fields:    Translation:Humans
  30. Botas P, Grassberger C, Sharp G, Paganetti H. Density overwrites of internal tumor volumes in intensity modulated proton therapy plans for mobile lung tumors. Phys Med Biol. 2018 01 30; 63(3):035023. PMID: 29219119.
    Citations: 2     Fields:    Translation:Humans
  31. Gentile MS, Yeap BY, Paganetti H, Goebel CP, Gaudet DE, Gallotto SL, Weyman EA, Morgan ML, MacDonald SM, Giantsoudi D, Adams J, Tarbell NJ, Kooy H, Yock TI. Brainstem Injury in Pediatric Patients With Posterior Fossa Tumors Treated With Proton Beam Therapy and Associated Dosimetric Factors. Int J Radiat Oncol Biol Phys. 2018 03 01; 100(3):719-729. PMID: 29413284.
    Citations:    Fields:    Translation:HumansPHPublic Health
  32. Toltz A, Hoesl M, Schuemann J, Seuntjens J, Lu HM, Paganetti H. Time-resolved diode dosimetry calibration through Monte Carlo modeling for in vivo passive scattered proton therapy range verification. J Appl Clin Med Phys. 2017 Nov; 18(6):200-205. PMID: 29082601.
    Citations: 1     Fields:    Translation:Humans
  33. Geng C, Paganetti H, Grassberger C. Prediction of Treatment Response for Combined Chemo- and Radiation Therapy for Non-Small Cell Lung Cancer Patients Using a Bio-Mathematical Model. Sci Rep. 2017 10 19; 7(1):13542. PMID: 29051600.
    Citations: 1     Fields:    
  34. Tran LT, Chartier L, Bolst D, Pogossov A, Guatelli S, Petasecca M, Lerch MLF, Prokopovich DA, Reinhard MI, Clasie B, Depauw N, Kooy H, Flanz JB, McNamara A, Paganetti H, Beltran C, Furutani K, Perevertaylo VL, Jackson M, Rosenfeld AB. Characterization of proton pencil beam scanning and passive beam using a high spatial resolution solid-state microdosimeter. Med Phys. 2017 Nov; 44(11):6085-6095. PMID: 28887837.
    Citations:    Fields:    
  35. Paganetti H. Relating the proton relative biological effectiveness to tumor control and normal tissue complication probabilities assuming interpatient variability in a/ß. Acta Oncol. 2017 Nov; 56(11):1379-1386. PMID: 28918679.
    Citations: 3     Fields:    Translation:HumansCells
  36. McMahon SJ, McNamara AL, Schuemann J, Paganetti H, Prise KM. A general mechanistic model enables predictions of the biological effectiveness of different qualities of radiation. Sci Rep. 2017 09 07; 7(1):10790. PMID: 28883414.
    Citations: 4     Fields:    
  37. Manem VSK, Grassberger C, Paganetti H. Predicting Organ-Specific Risk Interactions between Radiation and Chemotherapy in Secondary Cancer Survivors. Cancers (Basel). 2017 Sep 06; 9(9). PMID: 28878202.
    Citations:    
  38. Kry SF, Bednarz B, Howell RM, Dauer L, Followill D, Klein E, Paganetti H, Wang B, Wuu CS, George Xu X. AAPM TG 158: Measurement and calculation of doses outside the treated volume from external-beam radiation therapy. Med Phys. 2017 Oct; 44(10):e391-e429. PMID: 28688159.
    Citations: 7     Fields:    
  39. Sung W, Ye SJ, McNamara AL, McMahon SJ, Hainfeld J, Shin J, Smilowitz HM, Paganetti H, Schuemann J. Correction: Dependence of gold nanoparticle radiosensitization on cell geometry. Nanoscale. 2017 08 10; 9(31):11338. PMID: 28758663.
    Citations:    Fields:    
  40. Sorriaux J, Testa M, Paganetti H, Bertrand D, Lee JA, Palmans H, Vynckier S, Sterpin E. Consistency in quality correction factors for ionization chamber dosimetry in scanned proton beam therapy. Med Phys. 2017 Sep; 44(9):4919-4927. PMID: 28656604.
    Citations:    Fields:    Translation:Humans
  41. Ramos-Méndez J, Schuemann J, Incerti S, Paganetti H, Schulte R, Faddegon B. Flagged uniform particle splitting for variance reduction in proton and carbon ion track-structure simulations. Phys Med Biol. 2017 Jul 06; 62(15):5908-5925. PMID: 28594336.
    Citations: 2     Fields:    Translation:Humans
  42. Grassberger C, Paganetti H. Varying relative biological effectiveness in proton therapy: knowledge gaps versus clinical significance. Acta Oncol. 2017 Jun; 56(6):761-762. PMID: 28464735.
    Citations: 1     Fields:    Translation:HumansCells
  43. Sung W, Ye SJ, McNamara AL, McMahon SJ, Hainfeld J, Shin J, Smilowitz HM, Paganetti H, Schuemann J. Dependence of gold nanoparticle radiosensitization on cell geometry. Nanoscale. 2017 May 11; 9(18):5843-5853. PMID: 28429022.
    Citations: 7     Fields:    
  44. Sorriaux J, Testa M, Paganetti H, Orban de Xivry J, Lee JA, Traneus E, Souris K, Vynckier S, Sterpin E. Experimental assessment of proton dose calculation accuracy in inhomogeneous media. Phys Med. 2017 Jun; 38:10-15. PMID: 28610689.
    Citations:    Fields:    Translation:Humans
  45. Underwood TS, Sung W, McFadden CH, McMahon SJ, Hall DC, McNamara AL, Paganetti H, Sawakuchi GO, Schuemann J. Comparing stochastic proton interactions simulated using TOPAS-nBio to experimental data from fluorescent nuclear track detectors. Phys Med Biol. 2017 04 21; 62(8):3237-3249. PMID: 28350546.
    Citations:    Fields:    Translation:Cells
  46. Cho J, Grogg K, Min CH, Zhu X, Paganetti H, Lee HC, El Fakhri G. Feasibility study of using fall-off gradients of early and late PET scans for proton range verification. Med Phys. 2017 May; 44(5):1734-1746. PMID: 28273345.
    Citations:    Fields:    Translation:Humans
  47. Giantsoudi D, De Man B, Verburg J, Trofimov A, Jin Y, Wang G, Gjesteby L, Paganetti H. Metal artifacts in computed tomography for radiation therapy planning: dosimetric effects and impact of metal artifact reduction. Phys Med Biol. 2017 04 21; 62(8):R49-R80. PMID: 28323641.
    Citations: 3     Fields:    Translation:Humans
  48. Hall DC, Trofimov AV, Winey BA, Liebsch NJ, Paganetti H. Predicting Patient-specific Dosimetric Benefits of Proton Therapy for Skull-base Tumors Using a Geometric Knowledge-based Method. Int J Radiat Oncol Biol Phys. 2017 04 01; 97(5):1087-1094. PMID: 28332994.
    Citations: 2     Fields:    Translation:Humans
  49. Giantsoudi D, Seco J, Eaton BR, Simeone FJ, Kooy H, Yock TI, Tarbell NJ, DeLaney TF, Adams J, Paganetti H, MacDonald SM. Evaluating Intensity Modulated Proton Therapy Relative to Passive Scattering Proton Therapy for Increased Vertebral Column Sparing in Craniospinal Irradiation in Growing Pediatric Patients. Int J Radiat Oncol Biol Phys. 2017 05 01; 98(1):37-46. PMID: 28587051.
    Citations: 1     Fields:    Translation:HumansCells
  50. Underwood TS, Voog JC, Moteabbed M, Tang S, Soffen E, Cahlon O, Lu HM, Zietman AL, Efstathiou JA, Paganetti H. Hydrogel rectum-prostate spacers mitigate the uncertainties in proton relative biological effectiveness associated with anterior-oblique beams. Acta Oncol. 2017 Apr; 56(4):575-581. PMID: 28075206.
    Citations:    Fields:    Translation:Humans
  51. Grassberger C, Scott JG, Paganetti H. Biomathematical Optimization of Radiation Therapy in the Era of Targeted Agents. Int J Radiat Oncol Biol Phys. 2017 01 01; 97(1):13-17. PMID: 27979444.
    Citations:    Fields:    Translation:Humans
  52. McNamara A, Geng C, Turner R, Mendez JR, Perl J, Held K, Faddegon B, Paganetti H, Schuemann J. Validation of the radiobiology toolkit TOPAS-nBio in simple DNA geometries. Phys Med. 2017 Jan; 33:207-215. PMID: 28017738.
    Citations: 8     Fields:    Translation:Cells
  53. Geng C, Daartz J, Lam-Tin-Cheung K, Bussiere M, Shih HA, Paganetti H, Schuemann J. Limitations of analytical dose calculations for small field proton radiosurgery. Phys Med Biol. 2017 01 07; 62(1):246-257. PMID: 27991438.
    Citations:    Fields:    Translation:Humans
  54. Grassberger C, Paganetti H. Methodologies in the modeling of combined chemo-radiation treatments. Phys Med Biol. 2016 11 07; 61(21):R344-R367. PMID: 27758980.
    Citations: 1     Fields:    
  55. Yu JB, Mattes M, Thrasher A, Shu HG, De Los Santos JF, Paganetti H, Koontz BF, Abraham C, Balboni TA. Attitudes of radiation oncologists toward palliative and supportive care in the United States: Report on National Membership Survey by the American Society for Radiation Oncology (ASTRO). J Clin Oncol. 2016 Oct 09; 34(26_suppl):105. PMID: 28156660.
    Citations:    
  56. Qin N, Botas P, Giantsoudi D, Schuemann J, Tian Z, Jiang SB, Paganetti H, Jia X. Recent developments and comprehensive evaluations of a GPU-based Monte Carlo package for proton therapy. Phys Med Biol. 2016 10 21; 61(20):7347-7362. PMID: 27694712.
    Citations: 1     Fields:    
  57. Giantsoudi D, Adams J, MacDonald SM, Paganetti H. Proton Treatment Techniques for Posterior Fossa Tumors: Consequences for Linear Energy Transfer and Dose-Volume Parameters for the Brainstem and Organs at Risk. Int J Radiat Oncol Biol Phys. 2017 02 01; 97(2):401-410. PMID: 27986346.
    Citations: 3     Fields:    Translation:HumansCells
  58. McMahon SJ, Schuemann J, Paganetti H, Prise KM. Mechanistic Modelling of DNA Repair and Cellular Survival Following Radiation-Induced DNA Damage. Sci Rep. 2016 09 14; 6:33290. PMID: 27624453.
    Citations: 7     Fields:    Translation:HumansCells
  59. Wei RL, Mattes MD, Yu J, Thrasher A, Shu HK, Paganetti H, De Los Santos J, Koontz B, Abraham C, Balboni T. Attitudes of radiation oncologists toward palliative and supportive care in the United States: Report on national membership survey by the American Society for Radiation Oncology (ASTRO). Pract Radiat Oncol. 2017 Mar - Apr; 7(2):113-119. PMID: 28274395.
    Citations:    Fields: