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Harald Paganetti, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA248901 (PAGANETTI, HARALD) Jul 13, 2020 - Jun 30, 2025
    NIH/NCI
    Developing whole-body computational phantoms for blood dosimetry to model the impact of radiation on the immune system
    Role: Principal Investigator
  2. R01CA229178 (PAGANETTI, HARALD) Apr 1, 2019 - Mar 31, 2024
    NIH/NCI
    Fast Individualized Delivery Adaptation in Proton Therapy
    Role: Principal Investigator
  3. R01CA140735 (PAGANETTI, HARALD) Jul 1, 2009 - May 31, 2013
    NIH/NCI
    TOPAS: Fast and easy to use Monte Carlo system for proton therapy
    Role: Principal Investigator
  4. R01CA111590 (PAGANETTI, HARALD) Dec 1, 2004 - Apr 30, 2015
    NIH/NCI
    Four-dimensional Monte Carlo dose calculation
    Role: Principal Investigator
  5. U19CA021239 (HONG, THEODORE S) Apr 1, 1997 - Aug 31, 2019
    NIH/NCI
    Improving the Clinical Effectiveness and Understanding of the Biophysical Basis
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sung W, Grassberger C, McNamara AL, Basler L, Ehrbar S, Tanadini-Lang S, Hong TS, Paganetti H. A tumor-immune interaction model for hepatocellular carcinoma based on measured lymphocyte counts in patients undergoing radiotherapy. Radiother Oncol. 2020 Jul 15; 151:73-81. PMID: 32679308.
    Citations:    
  2. Zhu H, McNamara AL, McMahon SJ, Ramos-Mendez J, Henthorn NT, Faddegon B, Held KD, Perl J, Li J, Paganetti H, Schuemann J. Cellular Response to Proton Irradiation: A Simulation Study with TOPAS-nBio. Radiat Res. 2020 Jul 08; 194(1):9-21. PMID: 32401689.
    Citations:    
  3. Lalonde A, Winey BA, Verburg JM, Paganetti H, Sharp GC. Evaluation of CBCT scatter correction using deep convolutional neural networks for head and neck adaptive proton therapy. Phys Med Biol. 2020 Jun 24. PMID: 32580174.
    Citations:    
  4. Paganetti H, Depauw N, Johnson A, Forman RB, Lau J, Jimenez R. The risk for developing a secondary cancer after breast radiation therapy: Comparison of photon and proton techniques. Radiother Oncol. 2020 Aug; 149:212-218. PMID: 32464163.
    Citations:    
  5. DeLaney TF, Yock TI, Paganetti H. Assessing second cancer risk after primary cancer treatment with photon or proton radiotherapy. Cancer. 2020 Aug 01; 126(15):3397-3399. PMID: 32426850.
    Citations:    
  6. Shin J, Kooy HM, Paganetti H, Clasie B. DICOM-RT Ion interface to utilize MC simulations in routine clinical workflow for proton pencil beam radiotherapy. Phys Med. 2020 Jun; 74:1-10. PMID: 32388464.
    Citations:    
  7. Zhu H, McNamara AL, Ramos-Mendez J, McMahon SJ, Henthorn NT, Faddegon B, Held KD, Perl J, Li J, Paganetti H, Schuemann J. A parameter sensitivity study for simulating DNA damage after proton irradiation using TOPAS-nBio. Phys Med Biol. 2020 04 23; 65(8):085015. PMID: 32101803.
    Citations:    
  8. Meschini G, Kamp F, Hofmaier J, Reiner M, Sharp G, Paganetti H, Belka C, Wilkens JJ, Carlson DJ, Parodi K, Baroni G, Riboldi M. Modeling RBE-weighted dose variations in irregularly moving abdominal targets treated with carbon ion beams. Med Phys. 2020 Jul; 47(7):2768-2778. PMID: 32162332.
    Citations:    
  9. Faddegon B, Ramos-Méndez J, Schuemann J, McNamara A, Shin J, Perl J, Paganetti H. The TOPAS tool for particle simulation, a Monte Carlo simulation tool for physics, biology and clinical research. Phys Med. 2020 Apr; 72:114-121. PMID: 32247964.
    Citations:    
  10. Wang CC, McNamara AL, Shin J, Schuemann J, Grassberger C, Taghian AG, Jimenez RB, MacDonald SM, Paganetti H. End-of-Range Radiobiological Effect on Rib Fractures in Patients Receiving Proton Therapy for Breast Cancer. Int J Radiat Oncol Biol Phys. 2020 Jul 01; 107(3):449-454. PMID: 32240774.
    Citations:    
  11. McNamara AL, Hall DC, Shusharina N, Liu A, Wei X, Ajdari A, Mohan R, Liao Z, Paganetti H. Perspectives on the model-based approach to proton therapy trials: A retrospective study of a lung cancer randomized trial. Radiother Oncol. 2020 Jun; 147:8-14. PMID: 32224318.
    Citations:    
  12. Hammi A, Paganetti H, Grassberger C. 4D blood flow model for dose calculation to circulating blood and lymphocytes. Phys Med Biol. 2020 03 02; 65(5):055008. PMID: 32119649.
    Citations:    
  13. Gjesteby L, Shan H, Yang Q, Xi Y, Jin Y, Giantsoudi D, Paganetti H, De Man B, Wang G. A dual-stream deep convolutional network for reducing metal streak artifacts in CT images. Phys Med Biol. 2019 11 26; 64(23):235003. PMID: 31618724.
    Citations:    
  14. McNamara A, Willers H, Paganetti H. Modelling variable proton relative biological effectiveness for treatment planning. Br J Radiol. 2020 Mar; 93(1107):20190334. PMID: 31738081.
    Citations:    
  15. Marteinsdottir M, Schuemann J, Paganetti H. Impact of uncertainties in range and RBE on small field proton therapy. Phys Med Biol. 2019 10 10; 64(20):205005. PMID: 31519016.
    Citations:    
  16. Niyazi M, Niemierko A, Paganetti H, Söhn M, Schapira E, Goldberg S, Adams J, Kim V, Oh KS, Hwang WL, Lu HM, Belka C, Busse PM, Loeffler JS, Shih HA. Volumetric and actuarial analysis of brain necrosis in proton therapy using a novel mixture cure model. Radiother Oncol. 2020 01; 142:154-161. PMID: 31563411.
    Citations:    
  17. Abhyankar YS, Dev S, Sarun OS, Saxena A, Joshi R, Darbari H, Sajish C, Sonavane UB, Gavane V, Deshpande A, Dixit T, Harsh R, Badwe R, Rath GK, Laskar S, Faddegon B, Perl J, Paganetti H, Schuemann J, Srivastava A, Obcemea C, Nath AK, Sharma A, Buchsbaum J. Monte Carlo Processing on a Chip (MCoaC)-preliminary experiments toward the realization of optimal-hardware for TOPAS/Geant4 to drive discovery. Phys Med. 2019 Aug; 64:166-173. PMID: 31515016.
    Citations:    
  18. Zhu H, Chen Y, Sung W, McNamara AL, Tran LT, Burigo LN, Rosenfeld AB, Li J, Faddegon B, Schuemann J, Paganetti H. The microdosimetric extension in TOPAS: development and comparison with published data. Phys Med Biol. 2019 07 11; 64(14):145004. PMID: 31117056.
    Citations:    
  19. Meschini G, Seregni M, Molinelli S, Vai A, Phillips J, Sharp GC, Pella A, Valvo F, Ciocca M, Riboldi M, Paganetti H, Baroni G. Validation of a model for physical dose variations in irregularly moving targets treated with carbon ion beams. Med Phys. 2019 Aug; 46(8):3663-3673. PMID: 31206718.
    Citations:    
  20. Marteinsdottir M, Paganetti H. Applying a variable relative biological effectiveness (RBE) might affect the analysis of clinical trials comparing photon and proton therapy for prostate cancer. Phys Med Biol. 2019 06 05; 64(11):115027. PMID: 31082810.
    Citations:    
  21. Grassberger C, McClatchy D, Geng C, Kamran SC, Fintelmann F, Maruvka YE, Piotrowska Z, Willers H, Sequist LV, Hata AN, Paganetti H. Patient-Specific Tumor Growth Trajectories Determine Persistent and Resistant Cancer Cell Populations during Treatment with Targeted Therapies. Cancer Res. 2019 07 15; 79(14):3776-3788. PMID: 31113818.
    Citations:    
  22. Newpower M, Schuemann J, Mohan R, Paganetti H, Titt U. Comparing 2 Monte Carlo Systems in Use for Proton Therapy Research. Int J Part Ther. 2019; 6(1):18-27. PMID: 31773045.
    Citations:    
  23. Oesten H, Neubeck CV, Jakob A, Enghardt W, Krause M, McMahon SJ, Grassberger C, Paganetti H, Lühr A. Predicting In Vitro Cancer Cell Survival Based on Measurable Cell Characteristics. Radiat Res. 2019 06; 191(6):532-544. PMID: 31008688.
    Citations:    
  24. Li Y, Dykstra M, Best TD, Pursley J, Chopra N, Keane FK, Khandekar MJ, Sharp GC, Paganetti H, Willers H, Fintelmann FJ, Grassberger C. Differential inflammatory response dynamics in normal lung following stereotactic body radiation therapy with protons versus photons. Radiother Oncol. 2019 07; 136:169-175. PMID: 31015121.
    Citations:    
  25. Paganetti H, Blakely E, Carabe-Fernandez A, Carlson DJ, Das IJ, Dong L, Grosshans D, Held KD, Mohan R, Moiseenko V, Niemierko A, Stewart RD, Willers H. Report of the AAPM TG-256 on the relative biological effectiveness of proton beams in radiation therapy. Med Phys. 2019 Mar; 46(3):e53-e78. PMID: 30661238.
    Citations:    Fields:    
  26. Schuemann J, McNamara AL, Ramos-Méndez J, Perl J, Held KD, Paganetti H, Incerti S, Faddegon B. TOPAS-nBio: An Extension to the TOPAS Simulation Toolkit for Cellular and Sub-cellular Radiobiology. Radiat Res. 2019 02; 191(2):125-138. PMID: 30609382.
    Citations:    Fields:    
  27. Durante M, Paganetti H, Pompos A, Kry SF, Wu X, Grosshans DR. Report of a National Cancer Institute special panel: Characterization of the physical parameters of particle beams for biological research. Med Phys. 2019 Feb; 46(2):e37-e52. PMID: 30506898.
    Citations:    Fields:    
  28. Botas P, Kim J, Winey B, Paganetti H. Online adaption approaches for intensity modulated proton therapy for head and neck patients based on cone beam CTs and Monte Carlo simulations. Phys Med Biol. 2018 12 19; 64(1):015004. PMID: 30524097.
    Citations:    Fields:    
  29. McMahon SJ, Paganetti H, Prise KM. LET-weighted doses effectively reduce biological variability in proton radiotherapy planning. Phys Med Biol. 2018 11 09; 63(22):225009. PMID: 30412471.
    Citations:    Fields:    
  30. Schuemann J, McNamara AL, Warmenhoven JW, Henthorn NT, Kirkby KJ, Merchant MJ, Ingram S, Paganetti H, Held KD, Ramos-Mendez J, Faddegon B, Perl J, Goodhead DT, Plante I, Rabus H, Nettelbeck H, Friedland W, Kundrát P, Ottolenghi A, Baiocco G, Barbieri S, Dingfelder M, Incerti S, Villagrasa C, Bueno M, Bernal MA, Guatelli S, Sakata D, Brown JMC, Francis Z, Kyriakou I, Lampe N, Ballarini F, Carante MP, Davídková M, Štepán V, Jia X, Cucinotta FA, Schulte R, Stewart RD, Carlson DJ, Galer S, Kuncic Z, Lacombe S, Milligan J, Cho SH, Sawakuchi G, Inaniwa T, Sato T, Li W, Solov'yov AV, Surdutovich E, Durante M, Prise KM, McMahon SJ. A New Standard DNA Damage (SDD) Data Format. Radiat Res. 2019 01; 191(1):76-92. PMID: 30407901.
    Citations:    Fields:    
  31. Tucker SL, Xu T, Paganetti H, Deist T, Verma V, Choi N, Mohan R, Liao Z. Validation of Effective Dose as a Better Predictor of Radiation Pneumonitis Risk Than Mean Lung Dose: Secondary Analysis of a Randomized Trial. Int J Radiat Oncol Biol Phys. 2019 02 01; 103(2):403-410. PMID: 30291994.
    Citations:    Fields:    
  32. Paganetti H. Proton Relative Biological Effectiveness - Uncertainties and Opportunities. Int J Part Ther. 2018; 5(1):2-14. PMID: 30370315.
    Citations:    
  33. Chen Y, Grassberger C, Li J, Hong TS, Paganetti H. Impact of potentially variable RBE in liver proton therapy. Phys Med Biol. 2018 09 21; 63(19):195001. PMID: 30183674.
    Citations:    Fields:    
  34. McNamara AL, Ramos-Méndez J, Perl J, Held K, Dominguez N, Moreno E, Henthorn NT, Kirkby KJ, Meylan S, Villagrasa C, Incerti S, Faddegon B, Paganetti H, Schuemann J. Geometrical structures for radiation biology research as implemented in the TOPAS-nBio toolkit. Phys Med Biol. 2018 09 06; 63(17):175018. PMID: 30088810.
    Citations:    Fields:    
  35. Geng C, Paganetti H, Grassberger C. Author Correction: Prediction of Treatment Response for Combined Chemo- and Radiation Therapy for Non-Small Cell Lung Cancer Patients Using a Bio-Mathematical Model. Sci Rep. 2018 Aug 17; 8(1):12631. PMID: 30115991.
    Citations:    Fields:    
  36. Paganetti H, Giantsoudi D. Relative Biological Effectiveness Uncertainties and Implications for Beam Arrangements and Dose Constraints in Proton Therapy. Semin Radiat Oncol. 2018 06; 28(3):256-263. PMID: 29933885.
    Citations:    Fields:    Translation:HumansCells
  37. Ramos-Méndez J, Perl J, Schuemann J, McNamara A, Paganetti H, Faddegon B. Monte Carlo simulation of chemistry following radiolysis with TOPAS-nBio. Phys Med Biol. 2018 05 17; 63(10):105014. PMID: 29697057.
    Citations: 1     Fields:    
  38. Giantsoudi D, Adams J, MacDonald S, Paganetti H. Can differences in linear energy transfer and thus relative biological effectiveness compromise the dosimetric advantage of intensity-modulated proton therapy as compared to passively scattered proton therapy? Acta Oncol. 2018 Sep; 57(9):1259-1264. PMID: 29726722.
    Citations:    Fields:    Translation:HumansCellsCTClinical Trials
  39. Haas-Kogan D, Indelicato D, Paganetti H, Esiashvili N, Mahajan A, Yock T, Flampouri S, MacDonald S, Fouladi M, Stephen K, Kalapurakal J, Terezakis S, Kooy H, Grosshans D, Makrigiorgos M, Mishra K, Poussaint TY, Cohen K, Fitzgerald T, Gondi V, Liu A, Michalski J, Mirkovic D, Mohan R, Perkins S, Wong K, Vikram B, Buchsbaum J, Kun L. National Cancer Institute Workshop on Proton Therapy for Children: Considerations Regarding Brainstem Injury. Int J Radiat Oncol Biol Phys. 2018 05 01; 101(1):152-168. PMID: 29619963.
    Citations:    Fields:    
  40. Underwood TSA, Grassberger C, Bass R, MacDonald SM, Meyersohn NM, Yeap BY, Jimenez RB, Paganetti H. Asymptomatic Late-phase Radiographic Changes Among Chest-Wall Patients Are Associated With a Proton RBE Exceeding 1.1. Int J Radiat Oncol Biol Phys. 2018 07 15; 101(4):809-819. PMID: 29976493.
    Citations:    Fields:    
  41. Unkelbach J, Paganetti H. Robust Proton Treatment Planning: Physical and Biological Optimization. Semin Radiat Oncol. 2018 04; 28(2):88-96. PMID: 29735195.
    Citations: 1     Fields:    Translation:Humans
  42. Botas P, Grassberger C, Sharp G, Paganetti H. Density overwrites of internal tumor volumes in intensity modulated proton therapy plans for mobile lung tumors. Phys Med Biol. 2018 01 30; 63(3):035023. PMID: 29219119.
    Citations: 2     Fields:    Translation:Humans
  43. Gentile MS, Yeap BY, Paganetti H, Goebel CP, Gaudet DE, Gallotto SL, Weyman EA, Morgan ML, MacDonald SM, Giantsoudi D, Adams J, Tarbell NJ, Kooy H, Yock TI. Brainstem Injury in Pediatric Patients With Posterior Fossa Tumors Treated With Proton Beam Therapy and Associated Dosimetric Factors. Int J Radiat Oncol Biol Phys. 2018 03 01; 100(3):719-729. PMID: 29413284.
    Citations:    Fields:    Translation:HumansPHPublic Health
  44. Toltz A, Hoesl M, Schuemann J, Seuntjens J, Lu HM, Paganetti H. Time-resolved diode dosimetry calibration through Monte Carlo modeling for in vivo passive scattered proton therapy range verification. J Appl Clin Med Phys. 2017 Nov; 18(6):200-205. PMID: 29082601.
    Citations: 1     Fields:    Translation:Humans
  45. Geng C, Paganetti H, Grassberger C. Prediction of Treatment Response for Combined Chemo- and Radiation Therapy for Non-Small Cell Lung Cancer Patients Using a Bio-Mathematical Model. Sci Rep. 2017 10 19; 7(1):13542. PMID: 29051600.
    Citations: 1     Fields:    
  46. Tran LT, Chartier L, Bolst D, Pogossov A, Guatelli S, Petasecca M, Lerch MLF, Prokopovich DA, Reinhard MI, Clasie B, Depauw N, Kooy H, Flanz JB, McNamara A, Paganetti H, Beltran C, Furutani K, Perevertaylo VL, Jackson M, Rosenfeld AB. Characterization of proton pencil beam scanning and passive beam using a high spatial resolution solid-state microdosimeter. Med Phys. 2017 Nov; 44(11):6085-6095. PMID: 28887837.
    Citations:    Fields:    
  47. Paganetti H. Relating the proton relative biological effectiveness to tumor control and normal tissue complication probabilities assuming interpatient variability in a/ß. Acta Oncol. 2017 Nov; 56(11):1379-1386. PMID: 28918679.
    Citations: 3     Fields:    Translation:HumansCells
  48. McMahon SJ, McNamara AL, Schuemann J, Paganetti H, Prise KM. A general mechanistic model enables predictions of the biological effectiveness of different qualities of radiation. Sci Rep. 2017 09 07; 7(1):10790. PMID: 28883414.
    Citations: 4     Fields:    
  49. Manem VSK, Grassberger C, Paganetti H. Predicting Organ-Specific Risk Interactions between Radiation and Chemotherapy in Secondary Cancer Survivors. Cancers (Basel). 2017 Sep 06; 9(9). PMID: 28878202.
    Citations:    
  50. Kry SF, Bednarz B, Howell RM, Dauer L, Followill D, Klein E, Paganetti H, Wang B, Wuu CS, George Xu X. AAPM TG 158: Measurement and calculation of doses outside the treated volume from external-beam radiation therapy. Med Phys. 2017 Oct; 44(10):e391-e429. PMID: 28688159.
    Citations: 7     Fields:    
  51. Sung W, Ye SJ, McNamara AL, McMahon SJ, Hainfeld J, Shin J, Smilowitz HM, Paganetti H, Schuemann J. Correction: Dependence of gold nanoparticle radiosensitization on cell geometry. Nanoscale. 2017 08 10; 9(31):11338. PMID: 28758663.
    Citations:    Fields:    
  52. Sorriaux J, Testa M, Paganetti H, Bertrand D, Lee JA, Palmans H, Vynckier S, Sterpin E. Consistency in quality correction factors for ionization chamber dosimetry in scanned proton beam therapy. Med Phys. 2017 Sep; 44(9):4919-4927. PMID: 28656604.
    Citations:    Fields:    Translation:Humans
  53. Ramos-Méndez J, Schuemann J, Incerti S, Paganetti H, Schulte R, Faddegon B. Flagged uniform particle splitting for variance reduction in proton and carbon ion track-structure simulations. Phys Med Biol. 2017 Jul 06; 62(15):5908-5925. PMID: 28594336.
    Citations: 2     Fields: