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profileHarald Paganetti, Ph.D.

TitleProfessor of Radiation Oncology
InstitutionMassachusetts General Hospital
DepartmentRadiation Oncology
AddressMassachusetts General Hospital
Radiation Oncology
100 Blossom Street
Boston MA 02114
Phone617/726-5847
Fax617/726-2098
vCardDownload vCard (login for email)

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Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01CA140735     (PAGANETTI, HARALD)Jul 1, 2009 - Jun 30, 2016
NIH/NCI
TOPAS: Fast and easy to use Monte Carlo system for proton therapy
Role: Principal Investigator

R01CA111590     (PAGANETTI, HARALD)Dec 1, 2004 - Apr 30, 2015
NIH/NCI
Four-dimensional Monte Carlo dose calculation
Role: Principal Investigator

U19CA021239     (HONG, THEODORE S)Apr 1, 1997 - Aug 31, 2019
NIH/NCI
Improving the Clinical Effectiveness and Understanding of the Biophysical Basis
Role: Co-Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Manem VSK, Grassberger C, Paganetti H. Predicting Organ-Specific Risk Interactions between Radiation and Chemotherapy in Secondary Cancer Survivors. Cancers (Basel). 2017 Sep 06; 9(9). PMID: 28878202.
    View in: PubMed
  2. Sung W, Ye SJ, McNamara AL, McMahon SJ, Hainfeld J, Shin J, Smilowitz HM, Paganetti H, Schuemann J. Correction: Dependence of gold nanoparticle radiosensitization on cell geometry. Nanoscale. 2017 Aug 10; 9(31):11338. PMID: 28758663.
    View in: PubMed
  3. Kry SF, Bednarz B, Howell RM, Dauer L, Followill D, Klein E, Paganetti H, Wang B, Wuu CS, George Xu X. AAPM TG 158: Measurement and calculation of doses outside the treated volume from external-beam radiation therapy. Med Phys. 2017 Jul 08. PMID: 28688159.
    View in: PubMed
  4. Ramos-Méndez J, Schuemann J, Incerti S, Paganetti H, Schulte R, Faddegon B. Flagged uniform particle splitting for variance reduction in proton and carbon ion track-structure simulations. Phys Med Biol. 2017 Jul 06; 62(15):5908-5925. PMID: 28594336.
    View in: PubMed
  5. Sorriaux J, Testa M, Paganetti H, Bertrand D, Lee JA, Palmans H, Vynckier S, Sterpin E. Consistency in quality correction factors for ionization chamber dosimetry in scanned proton beam therapy. Med Phys. 2017 Jun 28. PMID: 28656604.
    View in: PubMed
  6. Sung W, Ye SJ, McNamara AL, McMahon SJ, Hainfeld J, Shin J, Smilowitz HM, Paganetti H, Schuemann J. Dependence of gold nanoparticle radiosensitization on cell geometry. Nanoscale. 2017 May 11; 9(18):5843-5853. PMID: 28429022.
    View in: PubMed
  7. Sorriaux J, Testa M, Paganetti H, Orban de Xivry J, Lee JA, Traneus E, Souris K, Vynckier S, Sterpin E. Experimental assessment of proton dose calculation accuracy in inhomogeneous media. Phys Med. 2017 Jun; 38:10-15. PMID: 28610689.
    View in: PubMed
  8. Underwood TS, Sung W, McFadden CH, McMahon SJ, Hall DC, McNamara AL, Paganetti H, Sawakuchi GO, Schuemann J. Comparing stochastic proton interactions simulated using TOPAS-nBio to experimental data from fluorescent nuclear track detectors. Phys Med Biol. 2017 Apr 21; 62(8):3237-3249. PMID: 28350546.
    View in: PubMed
  9. Cho J, Grogg K, Min CH, Zhu X, Paganetti H, Lee HC, El Fakhri G. Feasibility study of using fall-off gradients of early and late PET scans for proton range verification. Med Phys. 2017 May; 44(5):1734-1746. PMID: 28273345.
    View in: PubMed
  10. Giantsoudi D, De Man B, Verburg J, Trofimov A, Jin Y, Wang G, Gjesteby L, Paganetti H. Metal artifacts in computed tomography for radiation therapy planning: dosimetric effects and impact of metal artifact reduction. Phys Med Biol. 2017 Apr 21; 62(8):R49-R80. PMID: 28323641.
    View in: PubMed
  11. Hall DC, Trofimov AV, Winey BA, Liebsch NJ, Paganetti H. Predicting Patient-specific Dosimetric Benefits of Proton Therapy for Skull-base Tumors Using a Geometric Knowledge-based Method. Int J Radiat Oncol Biol Phys. 2017 Apr 01; 97(5):1087-1094. PMID: 28332994.
    View in: PubMed
  12. Giantsoudi D, Seco J, Eaton BR, Simeone FJ, Kooy H, Yock TI, Tarbell NJ, DeLaney TF, Adams J, Paganetti H, MacDonald SM. Evaluating Intensity Modulated Proton Therapy Relative to Passive Scattering Proton Therapy for Increased Vertebral Column Sparing in Craniospinal Irradiation in Growing Pediatric Patients. Int J Radiat Oncol Biol Phys. 2017 May 01; 98(1):37-46. PMID: 28587051.
    View in: PubMed
  13. Underwood TS, Voog JC, Moteabbed M, Tang S, Soffen E, Cahlon O, Lu HM, Zietman AL, Efstathiou JA, Paganetti H. Hydrogel rectum-prostate spacers mitigate the uncertainties in proton relative biological effectiveness associated with anterior-oblique beams. Acta Oncol. 2017 Apr; 56(4):575-581. PMID: 28075206.
    View in: PubMed
  14. Grassberger C, Scott JG, Paganetti H. Biomathematical Optimization of Radiation Therapy in the Era of Targeted Agents. Int J Radiat Oncol Biol Phys. 2017 Jan 01; 97(1):13-17. PMID: 27979444.
    View in: PubMed
  15. McNamara A, Geng C, Turner R, Mendez JR, Perl J, Held K, Faddegon B, Paganetti H, Schuemann J. Validation of the radiobiology toolkit TOPAS-nBio in simple DNA geometries. Phys Med. 2017 Jan; 33:207-215. PMID: 28017738.
    View in: PubMed
  16. Geng C, Daartz J, Lam-Tin-Cheung K, Bussiere M, Shih HA, Paganetti H, Schuemann J. Limitations of analytical dose calculations for small field proton radiosurgery. Phys Med Biol. 2017 Jan 07; 62(1):246-257. PMID: 27991438.
    View in: PubMed
  17. Grassberger C, Paganetti H. Methodologies in the modeling of combined chemo-radiation treatments. Phys Med Biol. 2016 Oct 19; 61(21):R344-R367. PMID: 27758980.
    View in: PubMed
  18. Yu JB, Mattes M, Thrasher A, Shu HG, De Los Santos JF, Paganetti H, Koontz BF, Abraham C, Balboni TA. Attitudes of radiation oncologists toward palliative and supportive care in the United States: Report on National Membership Survey by the American Society for Radiation Oncology (ASTRO). J Clin Oncol. 2016 Oct 09; 34(26_suppl):105. PMID: 28156660.
    View in: PubMed
  19. Qin N, Botas P, Giantsoudi D, Schuemann J, Tian Z, Jiang SB, Paganetti H, Jia X. Recent developments and comprehensive evaluations of a GPU-based Monte Carlo package for proton therapy. Phys Med Biol. 2016 Oct 03; 61(20):7347-7362. PMID: 27694712.
    View in: PubMed
  20. Giantsoudi D, Adams J, MacDonald SM, Paganetti H. Proton Treatment Techniques for Posterior Fossa Tumors: Consequences for Linear Energy Transfer and Dose-Volume Parameters for the Brainstem and Organs at Risk. Int J Radiat Oncol Biol Phys. 2017 Feb 01; 97(2):401-410. PMID: 27986346.
    View in: PubMed
  21. McMahon SJ, Schuemann J, Paganetti H, Prise KM. Mechanistic Modelling of DNA Repair and Cellular Survival Following Radiation-Induced DNA Damage. Sci Rep. 2016 Sep 14; 6:33290. PMID: 27624453.
    View in: PubMed
  22. Wei RL, Mattes MD, Yu J, Thrasher A, Shu HK, Paganetti H, De Los Santos J, Koontz B, Abraham C, Balboni T. Attitudes of radiation oncologists toward palliative and supportive care in the United States: Report on national membership survey by the American Society for Radiation Oncology (ASTRO). Pract Radiat Oncol. 2017 Mar - Apr; 7(2):113-119. PMID: 28274395.
    View in: PubMed
  23. Unkelbach J, Botas P, Giantsoudi D, Gorissen BL, Paganetti H. Reoptimization of Intensity Modulated Proton Therapy Plans Based on Linear Energy Transfer. Int J Radiat Oncol Biol Phys. 2016 Dec 01; 96(5):1097-1106. PMID: 27869082.
    View in: PubMed
  24. Durante M, Paganetti H. Nuclear physics in particle therapy: a review. Rep Prog Phys. 2016 Sep; 79(9):096702. PMID: 27540827.
    View in: PubMed
  25. Paganetti H, Yu CX. Photon radiotherapy has reached its limit in terms of catching up dosimetrically with proton therapy. Med Phys. 2016 Aug; 43(8):4470. PMID: 27487862.
    View in: PubMed
  26. McNamara AL, Kam WW, Scales N, McMahon SJ, Bennett JW, Byrne HL, Schuemann J, Paganetti H, Banati R, Kuncic Z. Dose enhancement effects to the nucleus and mitochondria from gold nanoparticles in the cytosol. Phys Med Biol. 2016 Aug 21; 61(16):5993-6010. PMID: 27435339; PMCID: PMC4993038 [Available on 08/21/17].
  27. Hall D, Perl J, Schuemann J, Faddegon B, Paganetti H. SU-F-T-139: Meeting the Challenges of Quality Control in the TOPAS Monte Carlo Simulation Toolkit for Proton Therapy. Med Phys. 2016 Jun; 43(6):3493-3494. PMID: 28047391.
    View in: PubMed
  28. Grassberger C, Paganetti H. WE-H-BRA-03: Development of a Model to Include the Evolution of Resistant Tumor Subpopulations Into the Treatment Optimization Process for Schedules Involving Targeted Agents in Chemoradiation Therapy. Med Phys. 2016 Jun; 43(6):3843. PMID: 28046274.
    View in: PubMed
  29. Giantsoudi D, Adams J, MacDonald S, Paganetti H. SU-F-T-206: Proton Treatment Techniques for Posterior Fossa Tumors: Consequences for LET and Dose/Volume Parameters for the Brainstem and Organs at Risk. Med Phys. 2016 Jun; 43(6):3509. PMID: 28048662.
    View in: PubMed
  30. Jin Y, Robinson V, Gjesteby L, Wang G, Verburg J, Giantsoudi D, Paganetti H, De Man B. MO-FG-CAMPUS-IeP2-05: Feasibility Demonstration of High-Voltage Clinical CT and Impact On X-Ray Penetration Through Metal Objects. Med Phys. 2016 Jun; 43(6):3720-3721. PMID: 28048722.
    View in: PubMed
  31. Geng C, Daartz J, Cheung K, Bussiere M, Shih H, Paganetti H, Schuemann J. SU-F-T-157: Physics Considerations Regarding Dosimetric Accuracy of Analytical Dose Calculations for Small Field Proton Therapy: A Monte Carlo Study. Med Phys. 2016 Jun; 43(6):3498. PMID: 28047361.
    View in: PubMed
  32. Marteinsdottir M, Schuemann J, Paganetti H. WE-AB-207B-06: Dose and Biological Uncertainties in Sarcoma. Med Phys. 2016 Jun; 43(6):3805. PMID: 28047901.
    View in: PubMed
  33. McMahon S, McNamara A, Schuemann J, Prise K, Paganetti H. WE-H-BRA-07: Mechanistic Modelling of the Relative Biological Effectiveness of Heavy Charged Particles. Med Phys. 2016 Jun; 43(6):3844. PMID: 28046397.
    View in: PubMed
  34. McNamara A, Underwood T, Wo J, Paganetti H. SU-F-T-132: Variable RBE Models Predict Possible Underestimation of Vaginal Dose for Anal Cancer Patients Treated Using Single-Field Proton Treatments. Med Phys. 2016 Jun; 43(6):3492. PMID: 28047446.
    View in: PubMed
  35. Hall D, Trofimov A, Winey B, Liebsch N, Paganetti H. TH-CD-209-09: Quickly Identifying Good Candidates for Proton Therapy From Geometric Considerations. Med Phys. 2016 Jun; 43(6):3887-3888. PMID: 28048225.
    View in: PubMed
  36. Underwood T, McFadden C, Trenholm D, Verburg J, Paganetti H, Sawakuchi G, Schuemann J. TH-CD-201-07: Experimentally Investigating Proton Energy Deposition On the Microscopic Scale Using Fluorescence Nuclear Track Detectors. Med Phys. 2016 Jun; 43(6):3870-3871. PMID: 28046465.
    View in: PubMed
  37. Underwood T, Grassberger C, Willers H, MacDonald S, Jimenez R, Paganetti H. WE-FG-202-03: Quantitative CT-Based Analysis to Assess Lung Injury Following Proton Radiotherapy. Med Phys. 2016 Jun; 43(6):3827. PMID: 28048337.
    View in: PubMed
  38. Botas P, Grassberger C, Sharp G, Qin N, Jia X, Jiang S, Paganetti H. SU-G-TeP1-06: Fast GPU Framework for Four-Dimensional Monte Carlo in Adaptive Intensity Modulated Proton Therapy (IMPT) for Mobile Tumors. Med Phys. 2016 Jun; 43(6):3653. PMID: 28048238.
    View in: PubMed
  39. Paganetti H. WE-FG-BRB-01: Clinical Significance of RBE Variations in Proton Therapy. Med Phys. 2016 Jun; 43(6):3822-3823. PMID: 28048194.
    View in: PubMed
  40. McNamara A, Perl J, Piersimoni P, Ramos-Mendez J, Faddegon B, Held K, Paganetti H, Schuemann J. WE-H-BRA-04: Biological Geometries for the Monte Carlo Simulation Toolkit TOPASNBio. Med Phys. 2016 Jun; 43(6):3843. PMID: 28048349.
    View in: PubMed
  41. Paganetti H. TH-D-BRC-03: Panel Member. Med Phys. 2016 Jun; 43(6):3892. PMID: 28046331.
    View in: PubMed
  42. Shin J, Jee K, Clasie B, Depauw N, Madden T, Sharp G, Paganetti H, Kooy H. SU-G-TeP4-04: An Automated Monte Carlo Based QA Framework for Pencil Beam Scanning Treatments. Med Phys. 2016 Jun; 43(6):3685. PMID: 28047026.
    View in: PubMed
  43. Unkelbach J, Botas P, Qin N, Jia X, Giantsoudi D, Paganetti H. TH-CD-209-06: LET-Based Adjustment of IMPT Plans Using Prioritized Optimization. Med Phys. 2016 Jun; 43(6):3887. PMID: 28047469.
    View in: PubMed
  44. Underwood T, Paganetti H. Variable Proton Relative Biological Effectiveness: How Do We Move Forward? Int J Radiat Oncol Biol Phys. 2016 May 01; 95(1):56-8. PMID: 27084627.
    View in: PubMed
  45. Yonekura Y, Tsujii H, Hopewell JW, Ortiz López P, Cosset JM, Paganetti H, Montelius A, Schardt D, Jones B, Nakamura T. Radiological protection in ion beam radiotherapy: practical guidance for clinical use of new technology. Ann ICRP. 2016 Jun; 45(1 Suppl):138-47. PMID: 26980799.
    View in: PubMed
  46. Liu Q, Underwood TS, Kung J, Wang M, Lu HM, Paganetti H, Held KD, Hong TS, Efstathiou JA, Willers H. Disruption of SLX4-MUS81 Function Increases the Relative Biological Effectiveness of Proton Radiation. Int J Radiat Oncol Biol Phys. 2016 May 01; 95(1):78-85. PMID: 27084631; PMCID: PMC4889010 [Available on 05/01/17].
  47. Underwood T, Giantsoudi D, Moteabbed M, Zietman A, Efstathiou J, Paganetti H, Lu HM. Can We Advance Proton Therapy for Prostate? Considering Alternative Beam Angles and Relative Biological Effectiveness Variations When Comparing Against Intensity Modulated Radiation Therapy. Int J Radiat Oncol Biol Phys. 2016 May 01; 95(1):454-64. PMID: 27084660.
    View in: PubMed
  48. McMahon SJ, Paganetti H, Prise KM. Optimising element choice for nanoparticle radiosensitisers. Nanoscale. 2016 Jan 07; 8(1):581-9. PMID: 26645621.
    View in: PubMed
  49. Geng C, Moteabbed M, Seco J, Gao Y, Xu XG, Ramos-Méndez J, Faddegon B, Paganetti H. Dose assessment for the fetus considering scattered and secondary radiation from photon and proton therapy when treating a brain tumor of the mother. Phys Med Biol. 2016 Jan 21; 61(2):683-95. PMID: 26716718.
    View in: PubMed
  50. Moteabbed M, Yock TI, Depauw N, Madden TM, Kooy HM, Paganetti H. Impact of Spot Size and Beam-Shaping Devices on the Treatment Plan Quality for Pencil Beam Scanning Proton Therapy. Int J Radiat Oncol Biol Phys. 2016 May 01; 95(1):190-8. PMID: 27084640; PMCID: PMC4834139 [Available on 05/01/17].
  51. Paganetti H, Zietman A. Why Is Proton Beam Therapy So Controversial? J Am Coll Radiol. 2015 Dec; 12(12 Pt A):1318-9. PMID: 26653836.
    View in: PubMed
  52. Hall DC, Makarova A, Paganetti H, Gottschalk B. Validation of nuclear models in Geant4 using the dose distribution of a 177 MeV proton pencil beam. Phys Med Biol. 2016 Jan 07; 61(1):N1-N10. PMID: 26611861.
    View in: PubMed
  53. Geng C, Moteabbed M, Xie Y, Schuemann J, Yock T, Paganetti H. Assessing the radiation-induced second cancer risk in proton therapy for pediatric brain tumors: the impact of employing a patient-specific aperture in pencil beam scanning. Phys Med Biol. 2016 Jan 07; 61(1):12-22. PMID: 26605679.
    View in: PubMed
  54. Verburg JM, Grassberger C, Dowdell S, Schuemann J, Seco J, Paganetti H. Automated Monte Carlo Simulation of Proton Therapy Treatment Plans. Technol Cancer Res Treat. 2016 Dec; 15(6):NP35-NP46. PMID: 26596915.
    View in: PubMed
  55. McNamara AL, Schuemann J, Paganetti H. A phenomenological relative biological effectiveness (RBE) model for proton therapy based on all published in vitro cell survival data. Phys Med Biol. 2015 Nov 07; 60(21):8399-416. PMID: 26459756; PMCID: PMC4634882 [Available on 11/07/16].
  56. Lin Y, Paganetti H, McMahon SJ, Schuemann J. Gold nanoparticle induced vasculature damage in radiotherapy: Comparing protons, megavoltage photons, and kilovoltage photons. Med Phys. 2015 Oct; 42(10):5890-902. PMID: 26429263; PMCID: PMC4575320.
  57. Giantsoudi D, Sethi RV, Yeap BY, Eaton BR, Ebb DH, Caruso PA, Rapalino O, Chen YL, Adams JA, Yock TI, Tarbell NJ, Paganetti H, MacDonald SM. Incidence of CNS Injury for a Cohort of 111 Patients Treated With Proton Therapy for Medulloblastoma: LET and RBE Associations for Areas of Injury. Int J Radiat Oncol Biol Phys. 2016 May 01; 95(1):287-96. PMID: 26691786.
    View in: PubMed
  58. Dowdell S, Grassberger C, Sharp G, Paganetti H. Fractionated Lung IMPT Treatments: Sensitivity to Setup Uncertainties and Motion Effects Based on Single-Field Homogeneity. Technol Cancer Res Treat. 2016 Oct; 15(5):689-96. PMID: 26208837.
    View in: PubMed
  59. Chetty IJ, Martel MK, Jaffray DA, Benedict SH, Hahn SM, Berbeco R, Deye J, Jeraj R, Kavanagh B, Krishnan S, Lee N, Low DA, Mankoff D, Marks LB, Ollendorf D, Paganetti H, Ross B, Siochi RA, Timmerman RD, Wong JW. Technology for Innovation in Radiation Oncology. Int J Radiat Oncol Biol Phys. 2015 Nov 01; 93(3):485-92. PMID: 26460989; PMCID: PMC4610140 [Available on 11/01/16].
  60. Polster L, Schuemann J, Rinaldi I, Burigo L, McNamara AL, Stewart RD, Attili A, Carlson DJ, Sato T, Ramos Méndez J, Faddegon B, Perl J, Paganetti H. Extension of TOPAS for the simulation of proton radiation effects considering molecular and cellular endpoints. Phys Med Biol. 2015 Jul 07; 60(13):5053-70. PMID: 26061666; PMCID: PMC4511084.
  61. Méndez JR, Perl J, Schümann J, Shin J, Paganetti H, Faddegon B. Improved efficiency in Monte Carlo simulation for passive-scattering proton therapy. Phys Med Biol. 2015 Jul 07; 60(13):5019-35. PMID: 26061457; PMCID: PMC4498399.
  62. Ramos-Méndez J, Perl J, Schümann J, Shin J, Paganetti H, Faddegon B. A framework for implementation of organ effect models in TOPAS with benchmarks extended to proton therapy. Phys Med Biol. 2015 Jul 07; 60(13):5037-52. PMID: 26061583; PMCID: PMC4498397.
  63. Sorriaux J, Testa M, Paganetti H, Bertrand D, de Xivry JO, Lee J, Palmans H, Vynckier S, Sterpin E. SU-F-BRD-15: Quality Correction Factors in Scanned Or Broad Proton Therapy Beams Are Indistinguishable. Med Phys. 2015 Jun; 42(6):3529. PMID: 26128494.
    View in: PubMed
  64. Geng C, Moteabbed M, Xu X, Paganetti H. TU-F-CAMPUS-T-02: Risk Assessment of Scattered Neutrons for a Fetus From Proton Therapy of a Brain Tumor During Pregnancy. Med Phys. 2015 Jun; 42(6):3636. PMID: 26129088.
    View in: PubMed
  65. Giantsoudi D, Jee K, Rose B, MacDonald S, Paganetti H. TU-EF-304-12: Proton Radiation Therapy for Left-Sided Breast Cancer: LET and RBE Considerations for Cardiac Toxicity. Med Phys. 2015 Jun; 42(6):3617. PMID: 26128972.
    View in: PubMed
  66. Hong X, Gao H, Schuemann J, Paganetti H. SU-E-T-769: T-Test Based Prior Error Estimate and Stopping Criterion for Monte Carlo Dose Calculation in Proton Therapy. Med Phys. 2015 Jun; 42(6):3514. PMID: 26128432.
    View in: PubMed
  67. McMahon S, Paganetti H, Prise K. MO-FG-BRA-06: Material Optimisation for Nanoparticle-Sensitized Radiotherapy. Med Phys. 2015 Jun; 42(6):3565. PMID: 26128709.
    View in: PubMed
  68. McNamara A, Schuemann J, Paganetti H. SU-F-BRD-13: A Phenomenological Relative Biological Effectiveness (RBE) Model for Proton Therapy Based On All Published in Vitro Cell Survival Data. Med Phys. 2015 Jun; 42(6):3528. PMID: 26128491.
    View in: PubMed
  69. Phillips J, Gueorguiev G, Grassberger C, Paganetti H, Sharp G. SU-E-T-639: Proton Dose Calculation for Irregular Motion Using a Sliding Interface. Med Phys. 2015 Jun; 42(6):3483. PMID: 26128302.
    View in: PubMed
  70. Lin Y, Held K, McMahon S, Paganetti H, Schuemann J. SU-E-T-518: Investigation of Gold Nanoparticle Radiosensitization for Carbon Ion Therapy. Med Phys. 2015 Jun; 42(6):3454. PMID: 26128182.
    View in: PubMed
  71. Ramos-Mendez J, Perl J, Schuemann J, Shin J, Paganetti H, Faddegon B. SU-E-T-466: Implementation of An Extension Module for Dose Response Models in the TOPAS Monte Carlo Toolkit. Med Phys. 2015 Jun; 42(6):3441. PMID: 26128130.
    View in: PubMed
  72. Qin N, Giantsoudi D, Tian Z, Schuemann J, Pompos A, Paganetti H, Jiang S, Jia X. SU-E-T-673: Recent Developments and Comprehensive Validations of a GPU-Based Proton Monte Carlo Simulation Package, GPMC. Med Phys. 2015 Jun; 42(6):3491. PMID: 26128337.
    View in: PubMed
  73. McNamara A, McMahon S, Lin Y, Paganetti H, Kuncic Z, Schuemann J. TU-F-CAMPUS-T-04: Using Gold Nanoparticles to Target Mitochondria in Radiation Therapy. Med Phys. 2015 Jun; 42(6):3644. PMID: 26129118.
    View in: PubMed
  74. Grassberger C, Sharp G, Fintelmann F, Paganetti H, Willers H. SU-E-J-247: Time Evolution of Radiation-Induced Lung Injury After Stereotactic Proton Therapy. Med Phys. 2015 Jun; 42(6):3323. PMID: 26127638.
    View in: PubMed
  75. Underwood T, Giantsoudi D, Moteabbed M, Zietman A, Efstathiou J, Paganetti H, Lu HM. TU-EF-304-05: Anterior Proton Beams for Prostate Treatments Lead to Substantial Elevations in Modeled RBE-Weighted Rectal Dose. Med Phys. 2015 Jun; 42(6):3615. PMID: 26128957.
    View in: PubMed
  76. Geng C, Schuemann J, Moteabbed M, Paganetti H. SU-E-T-567: Neutron Dose Equivalent Evaluation for Pencil Beam Scanning Proton Therapy with Apertures. Med Phys. 2015 Jun; 42(6):3466. PMID: 26128233.
    View in: PubMed
  77. Hong X, Paganetti H, Gao H. SU-E-T-22: A Deterministic Solver of the Boltzmann-Fokker-Planck Equation for Dose Calculation. Med Phys. 2015 Jun; 42(6):3335. PMID: 26127688.
    View in: PubMed
  78. Manem V, Grassberger C, Paganetti H. TH-AB-304-10: Modeling Organ Specific Mechanistic Interactions Between Radiation and Chemotherapy. Med Phys. 2015 Jun; 42(6):3703. PMID: 26129428.
    View in: PubMed
  79. Toltz A, Hoesl M, Schuemann J, Seuntjens J, Lu H, Paganetti H. SU-E-T-524: In-Vivo Diode Dosimetry Proton Therapy Range Verification Validation Study for Pediatric CSI. Med Phys. 2015 Jun; 42(6):3455. PMID: 26128185.
    View in: PubMed
  80. Moteabbed M, Depauw N, Kooy H, Yock T, Paganetti H. SU-F-BRD-12: When Does Pencil Beam Scanning Become Superior to Passive Scattered Proton Therapy for Pediatric Head and Neck Cancers? Med Phys. 2015 Jun; 42(6):3528. PMID: 26128492.
    View in: PubMed
  81. Gorissen BL, Giantsoudi D, Unkelbach J, Paganetti H. TU-EF-304-08: LET-Based Inverse Planning for IMPT. Med Phys. 2015 Jun; 42(6):3616. PMID: 26128963.
    View in: PubMed
  82. Seco J, Giantsoudi D, Eaton BR, Adams JA, Paganetti H, MacDonald S. SU-E-T-369: Evaluating Intensity Modulated Proton Therapy Relative to Passive Scattering Proton Therapy for Increased Vertebral Column Sparing in CSI of Pediatric Patients. Med Phys. 2015 Jun; 42(6):3418. PMID: 26128033.
    View in: PubMed
  83. Manem V, Paganetti H. SU-E-T-752: Three-Dimensional Carcinogenic Maps Induced by Photons and Protons. Med Phys. 2015 Jun; 42(6):3510. PMID: 26128418.
    View in: PubMed
  84. Ramos-Mendez J, Paganetti H, Faddegon B. SU-E-T-554: Monte Carlo Calculation of Source Terms and Attenuation Lengths for Neutrons Produced by 50-200 MeV Protons On Brass. Med Phys. 2015 Jun; 42(6):3463. PMID: 26128219.
    View in: PubMed
  85. Schuemann J, Giantsoudi D, Grassberger C, Paganetti H. SU-E-T-135: Assessing the Clinical Impact of Approximations in Analytical Dose Calculations for Proton Therapy. Med Phys. 2015 Jun; 42(6):3362. PMID: 26127799.
    View in: PubMed
  86. Paganetti H, El Fakhri G. Monitoring proton therapy with PET. Br J Radiol. 2015 Jul; 88(1051):20150173. PMID: 25989699; PMCID: PMC4628541.
  87. Lin Y, McMahon SJ, Paganetti H, Schuemann J. Biological modeling of gold nanoparticle enhanced radiotherapy for proton therapy. Phys Med Biol. 2015 May 21; 60(10):4149-68. PMID: 25953956.
    View in: PubMed
  88. Grassberger C, Dowdell S, Sharp G, Paganetti H. Motion mitigation for lung cancer patients treated with active scanning proton therapy. Med Phys. 2015 May; 42(5):2462-9. PMID: 25979039; PMCID: PMC4409624 [Available on 05/01/16].
  89. Schuemann J, Giantsoudi D, Grassberger C, Moteabbed M, Min CH, Paganetti H. Assessing the Clinical Impact of Approximations in Analytical Dose Calculations for Proton Therapy. Int J Radiat Oncol Biol Phys. 2015 Aug 01; 92(5):1157-1164. PMID: 26025779; PMCID: PMC4509834.
  90. Paganetti H. Relating proton treatments to photon treatments via the relative biological effectiveness-should we revise current clinical practice? Int J Radiat Oncol Biol Phys. 2015 Apr 01; 91(5):892-4. PMID: 25832682.
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  91. Liu Q, Ghosh P, Magpayo N, Testa M, Tang S, Gheorghiu L, Biggs P, Paganetti H, Efstathiou JA, Lu HM, Held KD, Willers H. Lung cancer cell line screen links fanconi anemia/BRCA pathway defects to increased relative biological effectiveness of proton radiation. Int J Radiat Oncol Biol Phys. 2015 Apr 01; 91(5):1081-9. PMID: 25832698.
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  92. Grogg K, Alpert NM, Zhu X, Min CH, Testa M, Winey B, Normandin MD, Shih HA, Paganetti H, Bortfeld T, El Fakhri G. Mapping (15)O production rate for proton therapy verification. Int J Radiat Oncol Biol Phys. 2015 Jun 01; 92(2):453-9. PMID: 25817530; PMCID: PMC4431894.
  93. Giantsoudi D, Schuemann J, Jia X, Dowdell S, Jiang S, Paganetti H. Validation of a GPU-based Monte Carlo code (gPMC) for proton radiation therapy: clinical cases study. Phys Med Biol. 2015 Mar 21; 60(6):2257-69. PMID: 25715661.
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  94. Wouters BG, Skarsgard LD, Gerweck LE, Carabe-Fernandez A, Wong M, Durand RE, Nielson D, Bussiere MR, Wagner M, Biggs P, Paganetti H, Suit HD. Radiobiological intercomparison of the 160 MeV and 230 MeV proton therapy beams at the Harvard Cyclotron Laboratory and at Massachusetts General Hospital. Radiat Res. 2015 Feb; 183(2):174-87. PMID: 25587741.
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  95. Nguyen J, Moteabbed M, Paganetti H. Assessment of uncertainties in radiation-induced cancer risk predictions at clinically relevant doses. Med Phys. 2015 Jan; 42(1):81-9. PMID: 25563249; PMCID: PMC4272381.
  96. Grassberger C, Lomax A, Paganetti H. Characterizing a proton beam scanning system for Monte Carlo dose calculation in patients. Phys Med Biol. 2015 Jan 21; 60(2):633-45. PMID: 25549079; PMCID: PMC4300341.
  97. Lin Y, McMahon SJ, Scarpelli M, Paganetti H, Schuemann J. Comparing gold nano-particle enhanced radiotherapy with protons, megavoltage photons and kilovoltage photons: a Monte Carlo simulation. Phys Med Biol. 2014 Dec 21; 59(24):7675-89. PMID: 25415297.
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  98. Yonekura Y, Tsujii H, Hopewell JW, López PO, Cosset JM, Paganetti H, Montelius A, Schardt D, Jones B, Nakamura T. ICRP Publication 127: Radiological Protection in Ion Beam Radiotherapy. Ann ICRP. 2014 Dec; 43(4):5-113. PMID: 25915952.
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  99. Min CH, Paganetti H, Winey BA, Adams J, MacDonald SM, Tarbell NJ, Yock TI. Evaluation of permanent alopecia in pediatric medulloblastoma patients treated with proton radiation. Radiat Oncol. 2014 Nov 18; 9:220. PMID: 25403752; PMCID: PMC4251676.
  100. Moteabbed M, Schuemann J, Paganetti H. Dosimetric feasibility of real-time MRI-guided proton therapy. Med Phys. 2014 Nov; 41(11):111713. PMID: 25370627; PMCID: PMC4209014.
  101. Paganetti H. Relative biological effectiveness (RBE) values for proton beam therapy. Variations as a function of biological endpoint, dose, and linear energy transfer. Phys Med Biol. 2014 Nov 21; 59(22):R419-72. PMID: 25361443.
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  102. Min CH, Zhu X, Grogg K, El Fakhri G, Winey B, Paganetti H. A Recommendation on How to Analyze In-Room PET for In Vivo Proton Range Verification Using a Distal PET Surface Method. Technol Cancer Res Treat. 2015 Jun; 14(3):320-5. PMID: 25246517; PMCID: PMC4898041.
  103. Frey K, Unholtz D, Bauer J, Debus J, Min CH, Bortfeld T, Paganetti H, Parodi K. Automation and uncertainty analysis of a method for in-vivo range verification in particle therapy. Phys Med Biol. 2014 Oct 07; 59(19):5903-19. PMID: 25211629.
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  104. Liebl J, Paganetti H, Zhu M, Winey BA. The influence of patient positioning uncertainties in proton radiotherapy on proton range and dose distributions. Med Phys. 2014 Sep; 41(9):091711. PMID: 25186386.
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  105. Phillips J, Gueorguiev G, Shackleford JA, Grassberger C, Dowdell S, Paganetti H, Sharp GC. Computing proton dose to irregularly moving targets. Phys Med Biol. 2014 Aug 07; 59(15):4261-73. PMID: 25029239; PMCID: PMC4145854.
  106. Testa M, Min CH, Verburg JM, Schümann J, Lu HM, Paganetti H. Range verification of passively scattered proton beams based on prompt gamma time patterns. Phys Med Biol. 2014 Aug 07; 59(15):4181-95. PMID: 25004257.
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  107. Schuemann J, Dowdell S, Grassberger C, Min CH, Paganetti H. Site-specific range uncertainties caused by dose calculation algorithms for proton therapy. Phys Med Biol. 2014 Aug 07; 59(15):4007-31. PMID: 24990623; PMCID: PMC4136435.
  108. Paganetti H. Monte Carlo simulations will change the way we treat patients with proton beams today. Br J Radiol. 2014 Aug; 87(1040):20140293. PMID: 24896200; PMCID: PMC4112394.
  109. Hünemohr N, Paganetti H, Greilich S, Jäkel O, Seco J. Tissue decomposition from dual energy CT data for MC based dose calculation in particle therapy. Med Phys. 2014 Jun; 41(6):061714. PMID: 24877809; PMCID: PMC4032427.
  110. Schuemann J, Giantsoudi D, Rinaldi I, Perl J, Faddegon B, Paganetti H. TH-A-19A-02: Expanding TOPAS Towards Biological Modeling. Med Phys. 2014 Jun; 41(6):533. PMID: 28037074.
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  111. Sorriaux J, Paganetti H, Testa M, Giantsoudi D, Schuemann J, Bertrand D, Orban de Xivry J, Lee J, Palmans H, Vynckier S, Sterpin E. SU-E-T-464: On the Equivalence of the Quality Correction Factor for Pencil Beam Scanning Proton Therapy. Med Phys. 2014 Jun; 41(6):333. PMID: 28036486.
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  112. Giantsoudi D, MacDonald S, Paganetti H. SU-E-T-375: Passive Scattering to Pencil-Beam-Scanning Comparison for Medulloblastoma Proton Therapy: LET Distributions and Radiobiological Implications. Med Phys. 2014 Jun; 41(6):311. PMID: 28037439.
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  113. Grassberger C, Daartz J, Dowdell S, Ruggieri T, Sharp G, Paganetti H. TH-A-19A-03: Impact of Proton Dose Calculation Method On Delivered Dose to Lung Tumors: Experiments in Thorax Phantom and Planning Study in Patient Cohort. Med Phys. 2014 Jun; 41(6):533. PMID: 28036612.
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  114. Liebl J, Paganetti H, Winey B. SU-E-T-324: The Influence of Patient Positioning Uncertainties in Proton Radiotherapy On Proton Range and Dose Distributions. Med Phys. 2014 Jun; 41(6):298-299. PMID: 28036998.
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  115. Dowdell S, Greilich S, Zimmerman F, Evans C, Paganetti H, Schuemann J. WE-D-BRF-01: FEATURED PRESENTATION - Investigating Particle Track Structures Using Fluorescent Nuclear Track Detectors and Monte Carlo Simulations. Med Phys. 2014 Jun; 41(6):495. PMID: 28037271.
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  116. Schuemann J, Dowdell S, Grassberger C, Paganetti H. TH-A-19A-06: Site-Specific Comparison of Analytical and Monte Carlo Based Dose Calculations. Med Phys. 2014 Jun; 41(6):534. PMID: 28037127.
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  117. Paganetti H, Stewart R, Carabe-Fernandez A. TU-A-BRE-01: The Relative Biological Effectiveness of Proton Beams Relative to Photon Beams. Med Phys. 2014 Jun; 41(6):445. PMID: 28036710.
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  118. Sterpin E, Sorriaux J, Schuemann J, Souris K, Lee J, Vynckier S, Jia X, Jiang S, Paganetti H. SU-E-T-180: Fano Cavity Test of Proton Transport in Monte Carlo Codes Running On GPU and Xeon Phi. Med Phys. 2014 Jun; 41(6):264. PMID: 28036964.
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  119. Moteabbed M, Trofimov A, Testa M, Sharp G, Wang Y, Paganetti H, Zietman A, Efstathiou J, Lu H. SU-E-T-616: Comparison of Plan Dose Accuracy for Anterior Vs. Lateral Fields in Proton Therapy of Prostate Cancer. Med Phys. 2014 Jun; 41(6):369. PMID: 28037706.
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  120. Testa M, Doolan P, H BE, Paganetti H, Lu HM. SU-E-J-158: Experimental Investigation of Proton Radiography Based On Time-Resolved Dose Measurements. Med Phys. 2014 Jun; 41(6):192-193. PMID: 28038055.
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  121. Dowdell S, Grassberger C, Paganetti H. SU-E-T-292: Sensitivity of Fractionated Lung IMPT Treatments to Setup Uncertainties and Motion Effects. Med Phys. 2014 Jun; 41(6):291. PMID: 28036966.
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  122. Lin Y, Paganetti H, Schuemann J. WE-G-BRE-04: Gold Nanoparticle Induced Vasculature Damage for Proton Therapy: Monte Carlo Simulation. Med Phys. 2014 Jun; 41(6):517. PMID: 28037669.
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  123. Lin Y, Paganetti H, Schuemann J. WE-G-BRE-02: Biological Modeling of Gold Nanoparticle Radiosensitization for Proton Therapy. Med Phys. 2014 Jun; 41(6):517. PMID: 28036686.
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  124. Giantsoudi D, Schuemann J, Dowdell S, Jia X, Jiang S, Paganetti H. TH-A-19A-11: Validation of GPU-Based Monte Carlo Code (gPMC) Versus Fully Implemented Monte Carlo Code (TOPAS) for Proton Radiation Therapy: Clinical Cases Study. Med Phys. 2014 Jun; 41(6):535. PMID: 28038006.
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  125. Moteabbed M, Yock TI, Paganetti H. The risk of radiation-induced second cancers in the high to medium dose region: a comparison between passive and scanned proton therapy, IMRT and VMAT for pediatric patients with brain tumors. Phys Med Biol. 2014 Jun 21; 59(12):2883-99. PMID: 24828559.
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  126. Gerweck LE, Huang P, Lu HM, Paganetti H, Zhou Y. Lifetime increased cancer risk in mice following exposure to clinical proton beam-generated neutrons. Int J Radiat Oncol Biol Phys. 2014 May 01; 89(1):161-6. PMID: 24725699; PMCID: PMC4298825.
  127. Grassberger C, Daartz J, Dowdell S, Ruggieri T, Sharp G, Paganetti H. Quantification of proton dose calculation accuracy in the lung. Int J Radiat Oncol Biol Phys. 2014 Jun 01; 89(2):424-30. PMID: 24726289; PMCID: PMC4028367.
  128. Sethi RV, Giantsoudi D, Raiford M, Malhi I, Niemierko A, Rapalino O, Caruso P, Yock TI, Tarbell NJ, Paganetti H, MacDonald SM. Patterns of failure after proton therapy in medulloblastoma; linear energy transfer distributions and relative biological effectiveness associations for relapses. Int J Radiat Oncol Biol Phys. 2014 Mar 01; 88(3):655-63. PMID: 24521681.
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  129. Testa M, Schümann J, Lu HM, Shin J, Faddegon B, Perl J, Paganetti H. Experimental validation of the TOPAS Monte Carlo system for passive scattering proton therapy. Med Phys. 2013 Dec; 40(12):121719. PMID: 24320505; PMCID: PMC4109425.
  130. Paganetti H. Advancing (proton) radiation therapy. Int J Radiat Oncol Biol Phys. 2013 Dec 01; 87(5):871-3. PMID: 24267966.
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  131. Dowdell S, Grassberger C, Paganetti H. Four-dimensional Monte Carlo simulations demonstrating how the extent of intensity-modulation impacts motion effects in proton therapy lung treatments. Med Phys. 2013 Dec; 40(12):121713. PMID: 24320499; PMCID: PMC3843755.
  132. Testa M, Verburg JM, Rose M, Min CH, Tang S, Bentefour el H, Paganetti H, Lu HM. Proton radiography and proton computed tomography based on time-resolved dose measurements. Phys Med Biol. 2013 Nov 21; 58(22):8215-33. PMID: 24200989.
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  133. Grosse N, Fontana AO, Hug EB, Lomax A, Coray A, Augsburger M, Paganetti H, Sartori AA, Pruschy M. Deficiency in homologous recombination renders Mammalian cells more sensitive to proton versus photon irradiation. Int J Radiat Oncol Biol Phys. 2014 Jan 01; 88(1):175-81. PMID: 24239385.
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  134. Cho J, Ibbott G, Gillin M, Gonzalez-Lepera C, Titt U, Paganetti H, Kerr M, Mawlawi O. Feasibility of proton-activated implantable markers for proton range verification using PET. Phys Med Biol. 2013 Nov 07; 58(21):7497-512. PMID: 24099853; PMCID: PMC3998106.
  135. Grogg K, Zhu X, Min CH, Winey B, Bortfeld T, Paganetti H, Shih HA, El Fakhri G. Feasibility of Using Distal Endpoints for In-room PET Range Verification of Proton Therapy. IEEE Trans Nucl Sci. 2013 Oct; 60(5):3290-3297. PMID: 24464031.
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  136. Bueno M, Paganetti H, Duch MA, Schuemann J. An algorithm to assess the need for clinical Monte Carlo dose calculation for small proton therapy fields based on quantification of tissue heterogeneity. Med Phys. 2013 Aug; 40(8):081704. PMID: 23927301.
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  137. Giantsoudi D, Grassberger C, Craft D, Niemierko A, Trofimov A, Paganetti H. Linear energy transfer-guided optimization in intensity modulated proton therapy: feasibility study and clinical potential. Int J Radiat Oncol Biol Phys. 2013 Sep 01; 87(1):216-22. PMID: 23790771; PMCID: PMC4520412.
  138. Dowdell S, Grassberger C, Sharp GC, Paganetti H. TU-A-108-02: A 4D Monte Carlo Study Quantifying Changes in the Interplay Effect as a Function of Treatment Delivery Parameters in Proton Beam Scanning for Lung. Med Phys. 2013 Jun; 40(6Part25):419-420. PMID: 28518840.
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  139. Giantsoudi D, Unkelbach J, Craft D, Zeng C, Trofimov A, Paganetti H. TH-A-116-02: Radiobiological Implications of Various Target and Beam Geometry Utilization in Treatment Planning for Intensity Modulated Proton Therapy. Med Phys. 2013 Jun; 40(6Part32):529. PMID: 28517882.
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  140. Phillips J, Gueorguiev G, Shackleford J, Grassberger C, Dowdell S, Paganetti H, Sharp G. TU-A-108-06: Computing Proton Dose to Irregularly Moving Targets. Med Phys. 2013 Jun; 40(6Part25):420. PMID: 28518846.
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  141. Schuemann J, Testa M, Bueno M, Min C, Moteabbed M, Giantsoudi D, Paganetti H. SU-E-T-451: Patient and Site-Specific Assessment of the Value of Routine Monte Carlo Dose Calculation in Proton Therapy. Med Phys. 2013 Jun; 40(6Part17):309. PMID: 28517710.
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  142. Parodi K, Polf J, Paganetti H, Schulte R. WE-A-WAB-01: New Technologies Addressing the Range Uncertainty of Proton Therapy. Med Phys. 2013 Jun; 40(6Part28):468. PMID: 28519923.
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  143. Huenemohr N, Paganetti H, Greilich S, Jaekel O, Seco J. TH-C-144-03: Tissue Decomposition From Dual Energy CT Data to Reduce Range Uncertainties in Proton and Carbon Radiotherapy. Med Phys. 2013 Jun; 40(6Part33):546. PMID: 28519213.
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  144. Dowdell S, Grassberger C, Paganetti H. TU-A-108-08: Comparison of Full Intensity Modulated and Single Field Uniform Dose Proton Beam Scanning Lung Treatments. Med Phys. 2013 Jun; 40(6Part25):421. PMID: 28518849.
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  145. Moteabbed M, Yock T, Paganetti H. TU-A-108-10: Pencil Beam Scanning Vs. Passive Scattered Proton Therapy for Pediatric Thoracic/pelvic Cancers. Med Phys. 2013 Jun; 40(6Part25):421. PMID: 28518880.
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  146. Perl J, Shin J, Schuemann J, Paganetti H, Faddegon B. TU-A-108-01: Four-Dimensional Monte Carlo Using the TOPAS TOol for PArticle Simulation. Med Phys. 2013 Jun; 40(6Part25):419. PMID: 28518854.
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  147. Grassberger C, Daartz J, Dowdell S, Verburg J, Sharp G, Paganetti H. MO-G-137-02: Experimental Validation of Clinical as Well as Monte Carlo Dose Calculation for Proton Therapy of Lung Cancer Patients. Med Phys. 2013 Jun; 40(6Part25):416. PMID: 28518883.
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  148. Wolf R, Paganetti H, Flanz J. SU-E-T-124: Assessing Quality Assurance of Proton Scattering Nozzles Using Monte Carlo. Med Phys. 2013 Jun; 40(6Part12):232. PMID: 28518994.
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  149. Testa M, Min C, Schuemann J, Verburg J, Lu H, Paganetti H. WE-G-500-04: A Novel Technique for In-Vivo and Real-Time Range Verification Based On the Characteristic Prompt Gamma Time-Structure of Passively Modulated Proton Beams. Med Phys. 2013 Jun; 40(6Part30):503. PMID: 28519183.
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  150. Grassberger C, Dowdell S, Sharp G, Paganetti H. SU-F-500-04: Motion Mitigation in Active Scanning Proton Therapy for Lung Cancer: A 4D Monte Carlo Study. Med Phys. 2013 Jun; 40(6Part23):383. PMID: 28518357.
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  151. Schuemann J, Dowdell S, Barbone G, Paganetti H. SU-E-T-404: Quantification of Proton Dose Enhancement Resulting From Gold Nanoparticles. Med Phys. 2013 Jun; 40(6Part17):297. PMID: 28517700.
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  152. Jia X, Schuemann J, Paganetti H, Jiang S. WE-F-105-03: Development of GPMC V2.0, a GPU-Based Monte Carlo Dose Calculation Package for Proton Radiotherapy. Med Phys. 2013 Jun; 40(6Part30):498. PMID: 28519186.
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  153. Ramos-Mendez J, Perl J, Schuemann J, Shin J, Faddegon B, Paganetti H. WE-C-108-07: Optimal Parameters for Variance Reduction in Monte Carlo Simulations for Proton Therapy. Med Phys. 2013 Jun; 40(6Part28):475. PMID: 28519918.
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  154. Beddar S, Deye J, Romeijn E, Mackie T, Paganetti H, Jin J, McGuire S. WE-E-116-01: Grantsmanship and Funding. Med Phys. 2013 Jun; 40(6Part30):497. PMID: 28519180.
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  155. Dowdell S, Grassberger C, Sharp GC, Paganetti H. Interplay effects in proton scanning for lung: a 4D Monte Carlo study assessing the impact of tumor and beam delivery parameters. Phys Med Biol. 2013 Jun 21; 58(12):4137-56. PMID: 23689035; PMCID: PMC3752993.
  156. Cho J, Ibbott G, Gillin M, Gonzalez-Lepera C, Min CH, Zhu X, El Fakhri G, Paganetti H, Mawlawi O. Determination of elemental tissue composition following proton treatment using positron emission tomography. Phys Med Biol. 2013 Jun 07; 58(11):3815-35. PMID: 23681070; PMCID: PMC3763743.
  157. Zeng C, Giantsoudi D, Grassberger C, Goldberg S, Niemierko A, Paganetti H, Efstathiou JA, Trofimov A. Maximizing the biological effect of proton dose delivered with scanned beams via inhomogeneous daily dose distributions. Med Phys. 2013 May; 40(5):051708. PMID: 23635256; PMCID: PMC3651218.
  158. Ramos-Méndez J, Perl J, Faddegon B, Schümann J, Paganetti H. Geometrical splitting technique to improve the computational efficiency in Monte Carlo calculations for proton therapy. Med Phys. 2013 Apr; 40(4):041718. PMID: 23556888; PMCID: PMC3618101.
  159. Paganetti H, van Luijk P. Biological considerations when comparing proton therapy with photon therapy. Semin Radiat Oncol. 2013 Apr; 23(2):77-87. PMID: 23473684.
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  160. Carabe A, España S, Grassberger C, Paganetti H. Clinical consequences of relative biological effectiveness variations in proton radiotherapy of the prostate, brain and liver. Phys Med Biol. 2013 Apr 07; 58(7):2103-17. PMID: 23470339.
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  161. Grassberger C, Dowdell S, Lomax A, Sharp G, Shackleford J, Choi N, Willers H, Paganetti H. Motion interplay as a function of patient parameters and spot size in spot scanning proton therapy for lung cancer. Int J Radiat Oncol Biol Phys. 2013 Jun 01; 86(2):380-6. PMID: 23462423; PMCID: PMC3646997.
  162. Min CH, Zhu X, Winey BA, Grogg K, Testa M, El Fakhri G, Bortfeld TR, Paganetti H, Shih HA. Clinical application of in-room positron emission tomography for in vivo treatment monitoring in proton radiation therapy. Int J Radiat Oncol Biol Phys. 2013 May 01; 86(1):183-9. PMID: 23391817; PMCID: PMC3640852.
  163. Besemer A, Paganetti H, Bednarz B. The clinical impact of uncertainties in the mean excitation energy of human tissues during proton therapy. Phys Med Biol. 2013 Feb 21; 58(4):887-902. PMID: 23337713; PMCID: PMC3590005.
  164. Paganetti H, Fontenot J. Proton therapy physics. Med Phys. 2013 Jan; 40(1):017301. PMID: 23298133.
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  165. Jia X, Schümann J, Paganetti H, Jiang SB. GPU-based fast Monte Carlo dose calculation for proton therapy. Phys Med Biol. 2012 Dec 07; 57(23):7783-97. PMID: 23128424; PMCID: PMC4474737.
  166. Perl J, Shin J, Schumann J, Faddegon B, Paganetti H. TOPAS: an innovative proton Monte Carlo platform for research and clinical applications. Med Phys. 2012 Nov; 39(11):6818-37. PMID: 23127075; PMCID: PMC3493036.
  167. Paganetti H. Assessment of the risk for developing a second malignancy from scattered and secondary radiation in radiation therapy. Health Phys. 2012 Nov; 103(5):652-61. PMID: 23032895; PMCID: PMC3464436.
  168. Butterworth KT, McGarry CK, Clasie B, Carabe-Fernandez A, Schuemann J, Depauw N, Tang S, McMahon SJ, Schettino G, O'Sullivan JM, Lu HM, Kooy H, Paganetti H, Hounsell AR, Held KD, Prise KM. Relative biological effectiveness (RBE) and out-of-field cell survival responses to passive scattering and pencil beam scanning proton beam deliveries. Phys Med Biol. 2012 Oct 21; 57(20):6671-80. PMID: 23022765.
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  169. Titt U, Bednarz B, Paganetti H. Comparison of MCNPX and Geant4 proton energy deposition predictions for clinical use. Phys Med Biol. 2012 Oct 21; 57(20):6381-93. PMID: 22996039; PMCID: PMC3496257.
  170. Paganetti H, Athar BS, Moteabbed M, A Adams J, Schneider U, Yock TI. Assessment of radiation-induced second cancer risks in proton therapy and IMRT for organs inside the primary radiation field. Phys Med Biol. 2012 Oct 07; 57(19):6047-61. PMID: 22968191.
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  171. Ramos-Mendez J, Perl J, Faddegon B, Paganetti H. SU-E-T-478: Geometrical Splitting Technique to Improve the Computational Efficiency in Monte Carlo Calculations for Proton Therapy. Med Phys. 2012 Jun; 39(6Part17):3815. PMID: 28517444.
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  172. Giantsoudi D, Paganetti H. SU-E-T-495: Monte Carlo Dose Verification of Passive Scattering Proton Therapy for Prostate Cancer. Med Phys. 2012 Jun; 39(6Part17):3819. PMID: 28517455.
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  173. Moteabbed M, Schuemann J, Paganetti H. SU-E-T-470: Comparison of Proton Treatment Planning and Monte Carlo Calculation Using TOPAS for Liver Cancer. Med Phys. 2012 Jun; 39(6Part17):3813. PMID: 28517462.
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  174. Perl J, Shin J, Schuemann J, Faddegon B, Paganetti H. SU-E-T-473: Performance Assessment of the TOPAS Tool for Particle Simulation for Proton Therapy Applications. Med Phys. 2012 Jun; 39(6Part17):3814. PMID: 28517451.
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  175. Testa M, Bentefour H, Rose M, Paganetti H, Lu H. MO-A-213AB-08: 2D Water Equivalent Path Length Imaging Technique for Pre-Treatment Range Verification in Proton Therapy. Med Phys. 2012 Jun; 39(6Part20):3860. PMID: 28517525.
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  176. Paganetti H, Moteabbed M, Athar B, Adams J, Schneider U, Yock T. SU-E-T-258: Assessment of Radiation Induced Second Cancer Risks in Proton Therapy and IMRT for Organs inside the Main Radiation Field. Med Phys. 2012 Jun; 39(6Part13):3762-3763. PMID: 28517309.
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  177. Zeng C, Giantsoudi D, Grassberger C, Goldberg S, Niemierko A, Paganetti H, Trofimov A. SU-E-T-552: Maximizing the Biological Effect of Proton Dose Delivered with Scanned Beam. Med Phys. 2012 Jun; 39(6Part18):3832. PMID: 28518512.
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  178. Schuemann J, Shin J, Perl J, Grassberger C, Verburg J, Faddegon B, Paganetti H. SU-E-T-500: Pencil-Beam versus Monte Carlo Based Dose Calculation for Proton Therapy Patients with Complex Geometries. Clinical Use of the TOPAS Monte Carlo System. Med Phys. 2012 Jun; 39(6Part18):3820. PMID: 28518479.
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  179. Dowdell S, Clasie B, Depauw N, Metcalfe P, Rosenfeld A, Kooy H, Flanz J, Paganetti H. MO-F-213AB-03: Potential Reduction in Out-Of-Field Dose in Pencil Beam Scanning Proton Therapy Through Use of a Patient-Specific Aperture. Med Phys. 2012 Jun; 39(6Part21):3872. PMID: 28518261.
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  180. Paganetti H. TU-G-BRCD-02: Do Uncertainties in Proton Therapy Limit Its Clinical Potential? Med Phys. 2012 Jun; 39(6Part24):3918-3919. PMID: 28518707.
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  181. Bueno M, Schuemann J, Duch M, Paganetti H. MO-F-BRB-03: A Method to Assess the Need for Clinical Monte Carlo Dose Calculations for Small Proton Therapy Fields. Med Phys. 2012 Jun; 39(6Part21):3874. PMID: 28518244.
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  182. Min C, Zhu X, Grogg K, Winey B, Fakhri G, Bortfeld T, Shih H, Paganetti H. MO-A-213AB-07: Evaluation of Distal Dose Surface with In-Room PET for Proton Therapy Monitoring. Med Phys. 2012 Jun; 39(6Part20):3860. PMID: 28517508.
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  183. Schümann J, Paganetti H, Shin J, Faddegon B, Perl J. Efficient voxel navigation for proton therapy dose calculation in TOPAS and Geant4. Phys Med Biol. 2012 Jun 07; 57(11):3281-93. PMID: 22572154; PMCID: PMC3367506.
  184. Paganetti H. Range uncertainties in proton therapy and the role of Monte Carlo simulations. Phys Med Biol. 2012 Jun 07; 57(11):R99-117. PMID: 22571913; PMCID: PMC3374500.
  185. Shin J, Perl J, Schümann J, Paganetti H, Faddegon BA. A modular method to handle multiple time-dependent quantities in Monte Carlo simulations. Phys Med Biol. 2012 Jun 07; 57(11):3295-308. PMID: 22572201; PMCID: PMC4477630.
  186. Dowdell SJ, Clasie B, Depauw N, Metcalfe P, Rosenfeld AB, Kooy HM, Flanz JB, Paganetti H. Monte Carlo study of the potential reduction in out-of-field dose using a patient-specific aperture in pencil beam scanning proton therapy. Phys Med Biol. 2012 May 21; 57(10):2829-42. PMID: 22513726; PMCID: PMC3373272.
  187. Efstathiou JA, Paly JJ, Lu HM, Athar BS, Moteabbed M, Niemierko A, Adams JA, Bekelman JE, Shipley WU, Zietman AL, Paganetti H. Adjuvant radiation therapy for early stage seminoma: proton versus photon planning comparison and modeling of second cancer risk. Radiother Oncol. 2012 Apr; 103(1):12-7. PMID: 22391053.
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  188. Carabe A, Moteabbed M, Depauw N, Schuemann J, Paganetti H. Range uncertainty in proton therapy due to variable biological effectiveness. Phys Med Biol. 2012 Mar 07; 57(5):1159-72. PMID: 22330133.
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  189. Moteabbed M, Geyer A, Drenkhahn R, Bolch WE, Paganetti H. Comparison of whole-body phantom designs to estimate organ equivalent neutron doses for secondary cancer risk assessment in proton therapy. Phys Med Biol. 2012 Jan 21; 57(2):499-515. PMID: 22217682.
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  190. Remmele S, Hesser J, Paganetti H, Bortfeld T. A deconvolution approach for PET-based dose reconstruction in proton radiotherapy. Phys Med Biol. 2011 Dec 07; 56(23):7601-19. PMID: 22086216.
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  191. Grassberger C, Paganetti H. Elevated LET components in clinical proton beams. Phys Med Biol. 2011 Oct 21; 56(20):6677-91. PMID: 21965268.
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  192. Attanasi F, Knopf A, Parodi K, Paganetti H, Bortfeld T, Rosso V, Del Guerra A. Extension and validation of an analytical model for in vivo PET verification of proton therapy--a phantom and clinical study. Phys Med Biol. 2011 Aug 21; 56(16):5079-98. PMID: 21775794.
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  193. Bednarz B, Chen G, Paganetti H, Han B, Ding A, Xu XG. COMPARISON OF PARTICLE-TRACKING FEATURES IN GEANT4 AND MCNPX CODES FOR APPLICATIONS IN MAPPING OF PROTON RANGE UNCERTAINTY. Nucl Technol. 2011 Jul; 175(1):2-5. PMID: 22389531.
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  194. Rinaldi I, Ferrari A, Mairani A, Paganetti H, Parodi K, Sala P. An integral test of FLUKA nuclear models with 160 MeV proton beams in multi-layer Faraday cups. Phys Med Biol. 2011 Jul 07; 56(13):4001-11. PMID: 21677365.
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  195. Zhu X, España S, Daartz J, Liebsch N, Ouyang J, Paganetti H, Bortfeld TR, El Fakhri G. Monitoring proton radiation therapy with in-room PET imaging. Phys Med Biol. 2011 Jul 07; 56(13):4041-57. PMID: 21677366; PMCID: PMC3141290.
  196. España S, Paganetti H. Uncertainties in planned dose due to the limited voxel size of the planning CT when treating lung tumors with proton therapy. Phys Med Biol. 2011 Jul 07; 56(13):3843-56. PMID: 21628773.
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  197. Bednarz B, Lu HM, Engelsman M, Paganetti H. Uncertainties and correction methods when modeling passive scattering proton therapy treatment heads with Monte Carlo. Phys Med Biol. 2011 May 07; 56(9):2837-54. PMID: 21478569; PMCID: PMC3175356.
  198. España S, Zhu X, Daartz J, El Fakhri G, Bortfeld T, Paganetti H. The reliability of proton-nuclear interaction cross-section data to predict proton-induced PET images in proton therapy. Phys Med Biol. 2011 May 07; 56(9):2687-98. PMID: 21464534; PMCID: PMC3124369.
  199. Moteabbed M, España S, Paganetti H. Monte Carlo patient study on the comparison of prompt gamma and PET imaging for range verification in proton therapy. Phys Med Biol. 2011 Feb 21; 56(4):1063-82. PMID: 21263174.
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  200. Carabe-Fernandez A, Dale RG, Paganetti H. Repair kinetic considerations in particle beam radiotherapy. Br J Radiol. 2011 Jun; 84(1002):546-55. PMID: 21266398; PMCID: PMC3473638.
  201. Grassberger C, Trofimov A, Lomax A, Paganetti H. Variations in linear energy transfer within clinical proton therapy fields and the potential for biological treatment planning. Int J Radiat Oncol Biol Phys. 2011 Aug 01; 80(5):1559-66. PMID: 21163588; PMCID: PMC3094592.
  202. Athar BS, Paganetti H. Comparison of second cancer risk due to out-of-field doses from 6-MV IMRT and proton therapy based on 6 pediatric patient treatment plans. Radiother Oncol. 2011 Jan; 98(1):87-92. PMID: 21159398; PMCID: PMC3056442.
  203. España S, Paganetti H. The impact of uncertainties in the CT conversion algorithm when predicting proton beam ranges in patients from dose and PET-activity distributions. Phys Med Biol. 2010 Dec 21; 55(24):7557-71. PMID: 21098912.
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  204. Bednarz B, Daartz J, Paganetti H. Dosimetric accuracy of planning and delivering small proton therapy fields. Phys Med Biol. 2010 Dec 21; 55(24):7425-38. PMID: 21098920; PMCID: PMC3376899.
  205. Carabe-Fernandez A, Dale RG, Hopewell JW, Jones B, Paganetti H. Fractionation effects in particle radiotherapy: implications for hypo-fractionation regimes. Phys Med Biol. 2010 Oct 07; 55(19):5685-700. PMID: 20826903.
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  206. Sarfehnia A, Clasie B, Chung E, Lu HM, Flanz J, Cascio E, Engelsman M, Paganetti H, Seuntjens J. Direct absorbed dose to water determination based on water calorimetry in scanning proton beam delivery. Med Phys. 2010 Jul; 37(7):3541-50. PMID: 20831061.
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  207. Knopf AC, Parodi K, Paganetti H, Bortfeld T, Daartz J, Engelsman M, Liebsch N, Shih H. Accuracy of proton beam range verification using post-treatment positron emission tomography/computed tomography as function of treatment site. Int J Radiat Oncol Biol Phys. 2011 Jan 01; 79(1):297-304. PMID: 20646839.
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  208. Gensheimer MF, Yock TI, Liebsch NJ, Sharp GC, Paganetti H, Madan N, Grant PE, Bortfeld T. In vivo proton beam range verification using spine MRI changes. Int J Radiat Oncol Biol Phys. 2010 Sep 01; 78(1):268-75. PMID: 20472369.
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  209. Athar BS, Bednarz B, Seco J, Hancox C, Paganetti H. Comparison of out-of-field photon doses in 6 MV IMRT and neutron doses in proton therapy for adult and pediatric patients. Phys Med Biol. 2010 May 21; 55(10):2879-91. PMID: 20427856; PMCID: PMC3376896.
  210. Paganetti H, Kooy H. Proton radiation in the management of localized cancer. Expert Rev Med Devices. 2010 Mar; 7(2):275-85. PMID: 20214431.
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  211. Suit H, DeLaney T, Goldberg S, Paganetti H, Clasie B, Gerweck L, Niemierko A, Hall E, Flanz J, Hallman J, Trofimov A. Proton vs carbon ion beams in the definitive radiation treatment of cancer patients. Radiother Oncol. 2010 Apr; 95(1):3-22. PMID: 20185186.
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  212. Xu XG, Paganetti H. Better radiation weighting factors for neutrons generated from proton treatment are needed. Radiat Prot Dosimetry. 2010 Mar; 138(4):291-4. PMID: 20172937.
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  213. McGurk R, Seco J, Riboldi M, Wolfgang J, Segars P, Paganetti H. Extension of the NCAT phantom for the investigation of intra-fraction respiratory motion in IMRT using 4D Monte Carlo. Phys Med Biol. 2010 Mar 07; 55(5):1475-90. PMID: 20157230; PMCID: PMC4482131.
  214. Clasie B, Wroe A, Kooy H, Depauw N, Flanz J, Paganetti H, Rosenfeld A. Assessment of out-of-field absorbed dose and equivalent dose in proton fields. Med Phys. 2010 Jan; 37(1):311-21. PMID: 20175494; PMCID: PMC2803717.
  215. Paganetti H, Athar BS, Bednarz B. Dose-rate effects when estimating risks for second malignancies: in regard to Fontenot et al (Int J Radiat Oncol Biol Phys 2009;74:616-622). Int J Radiat Oncol Biol Phys. 2009 Dec 01; 75(5):1624; author reply 1624-5. PMID: 19931743.
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  216. Henkner K, Sobolevsky N, Jäkel O, Paganetti H. Test of the nuclear interaction model in SHIELD-HIT and comparison to energy distributions from GEANT4. Phys Med Biol. 2009 Nov 21; 54(22):N509-17. PMID: 19864697.
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  217. Brenner DJ, Elliston CD, Hall EJ, Paganetti H. Reduction of the secondary neutron dose in passively scattered proton radiotherapy, using an optimized pre-collimator/collimator. Phys Med Biol. 2009 Oct 21; 54(20):6065-78. PMID: 19779218; PMCID: PMC3688272.
  218. Athar BS, Paganetti H. Neutron equivalent doses and associated lifetime cancer incidence risks for head & neck and spinal proton therapy. Phys Med Biol. 2009 Aug 21; 54(16):4907-26. PMID: 19641238.
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  219. Daartz J, Engelsman M, Paganetti H, Bussière MR. Field size dependence of the output factor in passively scattered proton therapy: influence of range, modulation, air gap, and machine settings. Med Phys. 2009 Jul; 36(7):3205-10. PMID: 19673219.
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  220. Knopf A, Parodi K, Bortfeld T, Shih HA, Paganetti H. Systematic analysis of biological and physical limitations of proton beam range verification with offline PET/CT scans. Phys Med Biol. 2009 Jul 21; 54(14):4477-95. PMID: 19556685.
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  221. Seco J, Robertson D, Trofimov A, Paganetti H. Breathing interplay effects during proton beam scanning: simulation and statistical analysis. Phys Med Biol. 2009 Jul 21; 54(14):N283-94. PMID: 19550002.
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  222. Paganetti H. Dose to water versus dose to medium in proton beam therapy. Phys Med Biol. 2009 Jul 21; 54(14):4399-421. PMID: 19550004.
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  223. Paganetti H, Goitein M, Parodi K. Spread-out antiproton beams deliver poor physical dose distributions for radiation therapy. Radiother Oncol. 2010 Apr; 95(1):79-86. PMID: 19394098.
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  224. Riboldi M, Chen GT, Baroni G, Paganetti H, Seco J. Design and testing of a simulation framework for dosimetric motion studies integrating an anthropomorphic computational phantom into four-dimensional Monte Carlo. Technol Cancer Res Treat. 2008 Dec; 7(6):449-56. PMID: 19044324; PMCID: PMC4472311.
  225. Paganetti H, Jiang H, Parodi K, Slopsema R, Engelsman M. Clinical implementation of full Monte Carlo dose calculation in proton beam therapy. Phys Med Biol. 2008 Sep 07; 53(17):4825-53. PMID: 18701772.
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  226. Jarlskog CZ, Paganetti H. Sensitivity of different dose scoring methods on organ-specific neutron dose calculations in proton therapy. Phys Med Biol. 2008 Sep 07; 53(17):4523-32. PMID: 18677040.
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  227. Knopf A, Parodi K, Paganetti H, Cascio E, Bonab A, Bortfeld T. Quantitative assessment of the physical potential of proton beam range verification with PET/CT. Phys Med Biol. 2008 Aug 07; 53(15):4137-51. PMID: 18635897.
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  228. Zacharatou Jarlskog C, Paganetti H. Risk of developing second cancer from neutron dose in proton therapy as function of field characteristics, organ, and patient age. Int J Radiat Oncol Biol Phys. 2008 Sep 01; 72(1):228-35. PMID: 18571337.
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  229. Xu XG, Bednarz B, Paganetti H. A review of dosimetry studies on external-beam radiation treatment with respect to second cancer induction. Phys Med Biol. 2008 Jul 07; 53(13):R193-241. PMID: 18540047; PMCID: PMC4009374.
  230. Suit H, Kooy H, Trofimov A, Farr J, Munzenrider J, DeLaney T, Loeffler J, Clasie B, Safai S, Paganetti H. Should positive phase III clinical trial data be required before proton beam therapy is more widely adopted? No. Radiother Oncol. 2008 Feb; 86(2):148-53. PMID: 18237800.
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  231. Zacharatou Jarlskog C, Lee C, Bolch WE, Xu XG, Paganetti H. Assessment of organ-specific neutron equivalent doses in proton therapy using computational whole-body age-dependent voxel phantoms. Phys Med Biol. 2008 Feb 07; 53(3):693-717. PMID: 18199910; PMCID: PMC2680614.
  232. Seco J, Sharp GC, Wu Z, Gierga D, Buettner F, Paganetti H. Dosimetric impact of motion in free-breathing and gated lung radiotherapy: a 4D Monte Carlo study of intrafraction and interfraction effects. Med Phys. 2008 Jan; 35(1):356-66. PMID: 18293590; PMCID: PMC2268084.
  233. Paganetti H. The impact of protons on the incidence of second malignancies in radiotherapy by Eric J. Hall; Supp.31-34 2007. Technol Cancer Res Treat. 2007 Dec; 6(6):661-2. PMID: 17994798.
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  234. Parodi K, Paganetti H, Shih HA, Michaud S, Loeffler JS, DeLaney TF, Liebsch NJ, Munzenrider JE, Fischman AJ, Knopf A, Bortfeld T. Patient study of in vivo verification of beam delivery and range, using positron emission tomography and computed tomography imaging after proton therapy. Int J Radiat Oncol Biol Phys. 2007 Jul 01; 68(3):920-34. PMID: 17544003; PMCID: PMC2047826.
  235. Parodi K, Ferrari A, Sommerer F, Paganetti H. Clinical CT-based calculations of dose and positron emitter distributions in proton therapy using the FLUKA Monte Carlo code. Phys Med Biol. 2007 Jun 21; 52(12):3369-87. PMID: 17664549; PMCID: PMC2292644.
  236. Jiang H, Seco J, Paganetti H. Effects of Hounsfield number conversion on CT based proton Monte Carlo dose calculations. Med Phys. 2007 Apr; 34(4):1439-49. PMID: 17500475; PMCID: PMC2292645.
  237. Seco J, Sharp GC, Turcotte J, Gierga D, Bortfeld T, Paganetti H. Effects of organ motion on IMRT treatments with segments of few monitor units. Med Phys. 2007 Mar; 34(3):923-34. PMID: 17441238; PMCID: PMC2034283.
  238. Parodi K, Paganetti H, Cascio E, Flanz JB, Bonab AA, Alpert NM, Lohmann K, Bortfeld T. PET/CT imaging for treatment verification after proton therapy: a study with plastic phantoms and metallic implants. Med Phys. 2007 Feb; 34(2):419-35. PMID: 17388158; PMCID: PMC2292642.
  239. Suit H, Goldberg S, Niemierko A, Ancukiewicz M, Hall E, Goitein M, Wong W, Paganetti H. Secondary carcinogenesis in patients treated with radiation: a review of data on radiation-induced cancers in human, non-human primate, canine and rodent subjects. Radiat Res. 2007 Jan; 167(1):12-42. PMID: 17214511.
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  240. Paganetti H, Bortfeld T, Delaney TF. Neutron dose in proton radiation therapy: in regard to Eric J. Hall (Int J Radiat Oncol Biol Phys 2006;65:1-7). Int J Radiat Oncol Biol Phys. 2006 Dec 01; 66(5):1594-5; author reply 1595. PMID: 17126219.
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  241. Bortfeld T, Paganetti H. The biologic relevance of daily dose variations in adaptive treatment planning. Int J Radiat Oncol Biol Phys. 2006 Jul 01; 65(3):899-906. PMID: 16751072.
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  242. Paganetti H. Monte Carlo calculations for absolute dosimetry to determine machine outputs for proton therapy fields. Phys Med Biol. 2006 Jun 07; 51(11):2801-12. PMID: 16723767; PMCID: PMC2292643.
  243. Kooy HM, Rosenthal SJ, Engelsman M, Mazal A, Slopsema RL, Paganetti H, Flanz JB. The prediction of output factors for spread-out proton Bragg peak fields in clinical practice. Phys Med Biol. 2005 Dec 21; 50(24):5847-56. PMID: 16333159.
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  244. Paganetti H. Changes in tumor cell response due to prolonged dose delivery times in fractionated radiation therapy. Int J Radiat Oncol Biol Phys. 2005 Nov 01; 63(3):892-900. PMID: 16199319.
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  245. Jiang H, Wang B, Xu XG, Suit HD, Paganetti H. Simulation of organ-specific patient effective dose due to secondary neutrons in proton radiation treatment. Phys Med Biol. 2005 Sep 21; 50(18):4337-53. PMID: 16148397.
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  246. Paganetti H. Interpretation of proton relative biological effectiveness using lesion induction, lesion repair, and cellular dose distribution. Med Phys. 2005 Aug; 32(8):2548-56. PMID: 16193785.
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  247. Paganetti H, Jiang H, Trofimov A. 4D Monte Carlo simulation of proton beam scanning: modelling of variations in time and space to study the interplay between scanning pattern and time-dependent patient geometry. Phys Med Biol. 2005 Mar 07; 50(5):983-90. PMID: 15798270.
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  248. Paganetti H, Jiang H, Adams JA, Chen GT, Rietzel E. Monte Carlo simulations with time-dependent geometries to investigate effects of organ motion with high temporal resolution. Int J Radiat Oncol Biol Phys. 2004 Nov 01; 60(3):942-50. PMID: 15465213.
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  249. Jiang H, Paganetti H. Adaptation of GEANT4 to Monte Carlo dose calculations based on CT data. Med Phys. 2004 Oct; 31(10):2811-8. PMID: 15543788.
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  250. Paganetti H, Jiang H, Lee SY, Kooy HM. Accurate Monte Carlo simulations for nozzle design, commissioning and quality assurance for a proton radiation therapy facility. Med Phys. 2004 Jul; 31(7):2107-18. PMID: 15305464.
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  251. Paganetti H. Four-dimensional Monte Carlo simulation of time-dependent geometries. Phys Med Biol. 2004 Mar 21; 49(6):N75-81. PMID: 15104330.
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  252. Flanz J, Paganetti H. Monte Carlo calculations in support of the commissioning of the Northeast Proton Therapy Center. Australas Phys Eng Sci Med. 2003 Dec; 26(4):156-61. PMID: 14995059.
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  253. Paganetti H. Foreword: Hadron therapy--from yesterday's physics laboratory to today's modern clinical routine. Technol Cancer Res Treat. 2003 Oct; 2(5):353-4. PMID: 14529301.
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  254. Paganetti H. Significance and implementation of RBE variations in proton beam therapy. Technol Cancer Res Treat. 2003 Oct; 2(5):413-26. PMID: 14529306.
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  255. Paganetti H, Gottschalk B. Test of GEANT3 and GEANT4 nuclear models for 160 MeV protons stopping in CH2. Med Phys. 2003 Jul; 30(7):1926-31. PMID: 12906211.
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  256. Suit H, Goldberg S, Niemierko A, Trofimov A, Adams J, Paganetti H, Chen GT, Bortfeld T, Rosenthal S, Loeffler J, Delaney T. Proton beams to replace photon beams in radical dose treatments. Acta Oncol. 2003; 42(8):800-8. PMID: 14968940.
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  257. Paganetti H, Niemierko A, Ancukiewicz M, Gerweck LE, Goitein M, Loeffler JS, Suit HD. Relative biological effectiveness (RBE) values for proton beam therapy. Int J Radiat Oncol Biol Phys. 2002 Jun 01; 53(2):407-21. PMID: 12023146.
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  258. Paganetti H. Nuclear interactions in proton therapy: dose and relative biological effect distributions originating from primary and secondary particles. Phys Med Biol. 2002 Mar 07; 47(5):747-64. PMID: 11931469.
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  259. Paganetti H, Goitein M. Biophysical modelling of proton radiation effects based on amorphous track models. Int J Radiat Biol. 2001 Sep; 77(9):911-28. PMID: 11576451.
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  260. Paganetti H, Gerweck LE, Goitein M. The general relation between tissue response to x-radiation (alpha/beta-values) and the relative biological effectiveness (RBE) of protons: prediction by the Katz track-structure model. Int J Radiat Biol. 2000 Jul; 76(7):985-98. PMID: 10923623.
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  261. Paganetti H, Goitein M. Radiobiological significance of beamline dependent proton energy distributions in a spread-out Bragg peak. Med Phys. 2000 May; 27(5):1119-26. PMID: 10841418.
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  262. Gottschalk B, Platais R, Paganetti H. Nuclear interactions of 160 MeV protons stopping in copper: a test of Monte Carlo nuclear models. Med Phys. 1999 Dec; 26(12):2597-601. PMID: 10619245.
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  263. Paganetti H. Monte Carlo method to study the proton fluence for treatment planning. Med Phys. 1998 Dec; 25(12):2370-5. PMID: 9874829.
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  264. Paganetti H. Calculation of the spatial variation of relative biological effectiveness in a therapeutic proton field for eye treatment. Phys Med Biol. 1998 Aug; 43(8):2147-57. PMID: 9725595.
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  265. Paganetti H, Olko P, Kobus H, Becker R, Schmitz T, Waligorski MP, Filges D, Müller-Gärtner HW. Calculation of relative biological effectiveness for proton beams using biological weighting functions. Int J Radiat Oncol Biol Phys. 1997 Feb 01; 37(3):719-29. PMID: 9112472.
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  266. Paganetti H, Schmitz T. The influence of the beam modulation technique on dose and RBE in proton radiation therapy. Phys Med Biol. 1996 Sep; 41(9):1649-63. PMID: 8884903.
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