Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Jen Sheen, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01GM129093 (SHEEN, JEN) Jul 1, 2018 - May 31, 2022
    Plant Nutrient-Growth Signaling Network
    Role: Principal Investigator
  2. R01GM070567 (SHEEN, JEN) Apr 1, 2004 - Dec 31, 2017
    Signaling mechanisms in plant innate immunity
    Role: Principal Investigator
  3. R01GM060493 (SHEEN, JEN) Sep 1, 2000 - Mar 31, 2019
    Glucose Signaling in Plants
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Liu KH, Diener A, Lin Z, Liu C, Sheen J. Primary nitrate responses mediated by calcium signalling and diverse protein phosphorylation. J Exp Bot. 2020 07 25; 71(15):4428-4441. PMID: 31985788.
    Citations: 5     Fields:    Translation:Cells
  2. Maheshwari P, Du H, Sheen J, Assmann SM, Albert R. Model-driven discovery of calcium-related protein-phosphatase inhibition in plant guard cell signaling. PLoS Comput Biol. 2019 10; 15(10):e1007429. PMID: 31658257.
    Citations: 4     Fields:    Translation:AnimalsCells
  3. Ramon M, Dang TVT, Broeckx T, Hulsmans S, Crepin N, Sheen J, Rolland F. Default Activation and Nuclear Translocation of the Plant Cellular Energy Sensor SnRK1 Regulate Metabolic Stress Responses and Development. Plant Cell. 2019 07; 31(7):1614-1632. PMID: 31123051.
    Citations: 14     Fields:    Translation:AnimalsCells
  4. Wu Y, Shi L, Li L, Fu L, Liu Y, Xiong Y, Sheen J. Integration of nutrient, energy, light, and hormone signalling via TOR in plants. J Exp Bot. 2019 04 15; 70(8):2227-2238. PMID: 30715492.
    Citations: 17     Fields:    Translation:AnimalsCells
  5. Jia M, Liu X, Xue H, Wu Y, Shi L, Wang R, Chen Y, Xu N, Zhao J, Shao J, Qi Y, An L, Sheen J, Yu F. Noncanonical ATG8-ABS3 interaction controls senescence in plants. Nat Plants. 2019 02; 5(2):212-224. PMID: 30664732.
    Citations: 8     Fields:    Translation:AnimalsCells
  6. Lee H, Jun YS, Cha OK, Sheen J. Mitogen-activated protein kinases MPK3 and MPK6 are required for stem cell maintenance in the Arabidopsis shoot apical meristem. Plant Cell Rep. 2019 Mar; 38(3):311-319. PMID: 30552452.
    Citations: 2     Fields:    Translation:Cells
  7. Chen GH, Liu MJ, Xiong Y, Sheen J, Wu SH. TOR and RPS6 transmit light signals to enhance protein translation in deetiolating Arabidopsis seedlings. Proc Natl Acad Sci U S A. 2018 12 11; 115(50):12823-12828. PMID: 30482859.
    Citations: 18     Fields:    Translation:AnimalsCells
  8. Shi L, Wu Y, Sheen J. TOR signaling in plants: conservation and innovation. Development. 2018 07 09; 145(13). PMID: 29986898.
    Citations: 34     Fields:    Translation:AnimalsCells
  9. Li Z, Zhang D, Xiong X, Yan B, Xie W, Sheen J, Li JF. A potent Cas9-derived gene activator for plant and mammalian cells. Nat Plants. 2017 Dec; 3(12):930-936. PMID: 29158545.
    Citations: 26     Fields:    Translation:HumansAnimals
  10. Kim HJ, Wu CY, Yu HM, Sheen J, Lee H. Dual CLAVATA3 Peptides in Arabidopsis Shoot Stem Cell Signaling. J Plant Biol. 2017 Oct; 60(5):506-512. PMID: 30310351.
    Citations: 4     
  11. Liu KH, Niu Y, Konishi M, Wu Y, Du H, Sun Chung H, Li L, Boudsocq M, McCormack M, Maekawa S, Ishida T, Zhang C, Shokat K, Yanagisawa S, Sheen J. Discovery of nitrate-CPK-NLP signalling in central nutrient-growth networks. Nature. 2017 05 18; 545(7654):311-316. PMID: 28489820.
    Citations: 57     Fields:    Translation:AnimalsCells
  12. Chung HS, Sheen J. MAPK Assays in Arabidopsis MAMP-PRR Signal Transduction. Methods Mol Biol. 2017; 1578:155-166. PMID: 28220422.
    Citations: 1     Fields:    Translation:AnimalsCells
  13. Li L, Sheen J. Dynamic and diverse sugar signaling. Curr Opin Plant Biol. 2016 10; 33:116-125. PMID: 27423125.
    Citations: 50     Fields:    Translation:AnimalsCells
  14. Xiong Y, Sheen J. Novel links in the plant TOR kinase signaling network. Curr Opin Plant Biol. 2015 Dec; 28:83-91. PMID: 26476687.
    Citations: 41     Fields:    Translation:Cells
  15. Cheng Z, Li JF, Niu Y, Zhang XC, Woody OZ, Xiong Y, Djonovic S, Millet Y, Bush J, McConkey BJ, Sheen J, Ausubel FM. Pathogen-secreted proteases activate a novel plant immune pathway. Nature. 2015 May 14; 521(7551):213-6. PMID: 25731164.
    Citations: 56     Fields:    Translation:AnimalsCells
  16. Li JF, Zhang D, Sheen J. Targeted plant genome editing via the CRISPR/Cas9 technology. Methods Mol Biol. 2015; 1284:239-55. PMID: 25757776.
    Citations: 8     Fields:    Translation:AnimalsCells
  17. Wu HY, Liu KH, Wang YC, Wu JF, Chiu WL, Chen CY, Wu SH, Sheen J, Lai EM. AGROBEST: an efficient Agrobacterium-mediated transient expression method for versatile gene function analyses in Arabidopsis seedlings. Plant Methods. 2014; 10:19. PMID: 24987449.
    Citations: 52     
  18. Sheen J. Master Regulators in Plant Glucose Signaling Networks. J Plant Biol. 2014 Apr; 57(2):67-79. PMID: 25530701.
    Citations: 53     
  19. Li JF, Zhang D, Sheen J. Epitope-tagged protein-based artificial miRNA screens for optimized gene silencing in plants. Nat Protoc. 2014 Apr; 9(4):939-49. PMID: 24675734.
    Citations: 8     Fields:    Translation:AnimalsCells
  20. Xiong Y, Sheen J. The role of target of rapamycin signaling networks in plant growth and metabolism. Plant Physiol. 2014 Feb; 164(2):499-512. PMID: 24385567.
    Citations: 67     Fields:    Translation:AnimalsCells
  21. Li JF, Zhang D, Sheen J. Cas9-based genome editing in Arabidopsis and tobacco. Methods Enzymol. 2014; 546:459-72. PMID: 25398353.
    Citations: 13     Fields:    Translation:AnimalsCells
  22. Hamel LP, Sheen J, Séguin A. Ancient signals: comparative genomics of green plant CDPKs. Trends Plant Sci. 2014 Feb; 19(2):79-89. PMID: 24342084.
    Citations: 43     Fields:    Translation:Animals
  23. Zhou J, Wu S, Chen X, Liu C, Sheen J, Shan L, He P. The Pseudomonas syringae effector HopF2 suppresses Arabidopsis immunity by targeting BAK1. Plant J. 2014 Jan; 77(2):235-45. PMID: 24237140.
    Citations: 33     Fields:    Translation:AnimalsCells
  24. Sheen J. The cytokinin side chain commands shooting. Dev Cell. 2013 Nov 25; 27(4):371-2. PMID: 24286823.
    Citations:    Fields:    Translation:Animals
  25. Li JF, Norville JE, Aach J, McCormack M, Zhang D, Bush J, Church GM, Sheen J. Multiplex and homologous recombination-mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9. Nat Biotechnol. 2013 Aug; 31(8):688-91. PMID: 23929339.
    Citations: 345     Fields:    Translation:AnimalsCells
  26. Xiong Y, Sheen J. Moving beyond translation: glucose-TOR signaling in the transcriptional control of cell cycle. . 2013 Jul 01; 12(13):1989-90. PMID: 23759578.
    Citations: 15     Translation:HumansAnimalsCells
  27. Ramon M, Ruelens P, Li Y, Sheen J, Geuten K, Rolland F. The hybrid four-CBS-domain KINß? subunit functions as the canonical ? subunit of the plant energy sensor SnRK1. Plant J. 2013 Jul; 75(1):11-25. PMID: 23551663.
    Citations: 31     Fields:    Translation:AnimalsCells
  28. Li JF, Chung HS, Niu Y, Bush J, McCormack M, Sheen J. Comprehensive protein-based artificial microRNA screens for effective gene silencing in plants. Plant Cell. 2013 May; 25(5):1507-22. PMID: 23645631.
    Citations: 37     Fields:    Translation:AnimalsCells
  29. Xiong Y, McCormack M, Li L, Hall Q, Xiang C, Sheen J. Glucose-TOR signalling reprograms the transcriptome and activates meristems. Nature. 2013 Apr 11; 496(7444):181-6. PMID: 23542588.
    Citations: 175     Fields:    Translation:AnimalsCells
  30. Fukumoto T, Kano A, Ohtani K, Inoue M, Yoshihara A, Izumori K, Tajima S, Shigematsu Y, Tanaka K, Ohkouchi T, Ishida Y, Nishizawa Y, Tada Y, Ichimura K, Gomi K, Yoo SD, Sheen J, Akimitsu K. Phosphorylation of D-allose by hexokinase involved in regulation of OsABF1 expression for growth inhibition in Oryza sativa L. Planta. 2013 May; 237(5):1379-91. PMID: 23397192.
    Citations: 6     Fields:    Translation:AnimalsCells
  31. Gao X, Chen X, Lin W, Chen S, Lu D, Niu Y, Li L, Cheng C, McCormack M, Sheen J, Shan L, He P. Bifurcation of Arabidopsis NLR immune signaling via Ca²?-dependent protein kinases. PLoS Pathog. 2013 Jan; 9(1):e1003127. PMID: 23382673.
    Citations: 98     Fields:    Translation:AnimalsCells
  32. Cheng C, Gao X, Feng B, Sheen J, Shan L, He P. Plant immune response to pathogens differs with changing temperatures. Nat Commun. 2013; 4:2530. PMID: 24067909.
    Citations: 40     Fields:    Translation:AnimalsCells
  33. Boudsocq M, Sheen J. CDPKs in immune and stress signaling. Trends Plant Sci. 2013 Jan; 18(1):30-40. PMID: 22974587.
    Citations: 127     Fields:    Translation:AnimalsCells
  34. Lee H, Khatri A, Plotnikov JM, Zhang XC, Sheen J. Complexity in differential peptide-receptor signaling: response to Segonzac et Al. and Mueller et Al. commentaries. Plant Cell. 2012 Aug; 24(8):3177-85. PMID: 22923676.
    Citations: 5     Fields:    Translation:Animals
  35. Sheen J. An interview with Jen Sheen. Trends Plant Sci. 2012 Jun; 17(6):321-2. PMID: 22860262.
    Citations:    Fields:    
  36. Liu KH, McCormack M, Sheen J. Targeted parallel sequencing of large genetically-defined genomic regions for identifying mutations in Arabidopsis. Plant Methods. 2012 Mar 30; 8:12. PMID: 22462410.
    Citations: 8     
  37. Hwang I, Sheen J, Müller B. Cytokinin signaling networks. Annu Rev Plant Biol. 2012; 63:353-80. PMID: 22554243.
    Citations: 187     Fields:    Translation:HumansAnimalsCells
  38. Niu Y, Sheen J. Transient expression assays for quantifying signaling output. Methods Mol Biol. 2012; 876:195-206. PMID: 22576097.
    Citations: 6     Fields:    Translation:AnimalsCells
  39. Li JF, Sheen J. DNA purification from multiple sources in plant research with homemade silica resins. Methods Mol Biol. 2012; 862:53-9. PMID: 22419488.
    Citations: 2     Fields:    Translation:Cells
  40. Xiong Y, Sheen J. Rapamycin and glucose-target of rapamycin (TOR) protein signaling in plants. J Biol Chem. 2012 Jan 20; 287(4):2836-42. PMID: 22134914.
    Citations: 87     Fields:    Translation:AnimalsCells
  41. Hamel LP, Benchabane M, Nicole MC, Major IT, Morency MJ, Pelletier G, Beaudoin N, Sheen J, Séguin A. Stress-responsive mitogen-activated protein kinases interact with the EAR motif of a poplar zinc finger protein and mediate its degradation through the 26S proteasome. Plant Physiol. 2011 Nov; 157(3):1379-93. PMID: 21873571.
    Citations: 11     Fields:    Translation:AnimalsCells
  42. Tena G, Boudsocq M, Sheen J. Protein kinase signaling networks in plant innate immunity. Curr Opin Plant Biol. 2011 Oct; 14(5):519-29. PMID: 21704551.
    Citations: 140     Fields:    Translation:AnimalsCells
  43. Lee H, Chah OK, Sheen J. Stem-cell-triggered immunity through CLV3p-FLS2 signalling. Nature. 2011 May 19; 473(7347):376-9. PMID: 21499263.
    Citations: 32     Fields:    Translation:AnimalsCells
  44. Sheen J. Discover and connect cellular signaling. Plant Physiol. 2010 Oct; 154(2):562-6. PMID: 20921185.
    Citations: 6     Fields:    Translation:AnimalsCells
  45. Boudsocq M, Willmann MR, McCormack M, Lee H, Shan L, He P, Bush J, Cheng SH, Sheen J. Differential innate immune signalling via Ca(2+) sensor protein kinases. Nature. 2010 Mar 18; 464(7287):418-22. PMID: 20164835.
    Citations: 273     Fields:    Translation:AnimalsCells
  46. Li JF, Li L, Sheen J. Protocol: a rapid and economical procedure for purification of plasmid or plant DNA with diverse applications in plant biology. Plant Methods. 2010 Jan 14; 6(1):1. PMID: 20180960.
    Citations: 17     
  47. Boudsocq M, Sheen J. . Calcium sensing and signaling. In: Abiotic Stress Adaptation in Plants: Physiological, Molecular and Genomic Foundation. 2010; 75-90.
  48. Cho YH, Sheen J, Yoo SD. Low glucose uncouples hexokinase1-dependent sugar signaling from stress and defense hormone abscisic acid and C2H4 responses in Arabidopsis. Plant Physiol. 2010 Mar; 152(3):1180-2. PMID: 20034964.
    Citations: 30     Fields:    Translation:AnimalsCells
  49. Fujii H, Chinnusamy V, Rodrigues A, Rubio S, Antoni R, Park SY, Cutler SR, Sheen J, Rodriguez PL, Zhu JK. In vitro reconstitution of an abscisic acid signalling pathway. Nature. 2009 Dec 03; 462(7273):660-4. PMID: 19924127.
    Citations: 354     Fields:    Translation:AnimalsCells
  50. Yoo SD, Cho Y, Sheen J. Emerging connections in the ethylene signaling network. Trends Plant Sci. 2009 May; 14(5):270-9. PMID: 19375376.
    Citations: 65     Fields:    Translation:Cells
  51. Cho JI, Ryoo N, Eom JS, Lee DW, Kim HB, Jeong SW, Lee YH, Kwon YK, Cho MH, Bhoo SH, Hahn TR, Park YI, Hwang I, Sheen J, Jeon JS. Role of the rice hexokinases OsHXK5 and OsHXK6 as glucose sensors. Plant Physiol. 2009 Feb; 149(2):745-59. PMID: 19010999.
    Citations: 59     Fields:    Translation:AnimalsCells
  52. Ramon M, Rolland F, Sheen J. Sugar sensing and signaling. Arabidopsis Book. 2008; 6:e0117. PMID: 22303242.
    Citations: 48     
  53. Yoo SD, Sheen J. MAPK signaling in plant hormone ethylene signal transduction. Plant Signal Behav. 2008 Oct; 3(10):848-9. PMID: 19704518.
    Citations: 13     Fields:    
  54. Baena-González E, Sheen J. Convergent energy and stress signaling. Trends Plant Sci. 2008 Sep; 13(9):474-82. PMID: 18701338.
    Citations: 183     Fields:    Translation:AnimalsCells
  55. Shan L, He P, Li J, Heese A, Peck SC, Nürnberger T, Martin GB, Sheen J. Bacterial effectors target the common signaling partner BAK1 to disrupt multiple MAMP receptor-signaling complexes and impede plant immunity. . 2008 Jul 17; 4(1):17-27. PMID: 18621007.
    Citations: 183     Translation:AnimalsCells
  56. Karve A, Rauh BL, Xia X, Kandasamy M, Meagher RB, Sheen J, Moore BD. Expression and evolutionary features of the hexokinase gene family in Arabidopsis. Planta. 2008 Aug; 228(3):411-25. PMID: 18481082.
    Citations: 33     Fields:    Translation:AnimalsCells
  57. Müller B, Sheen J. Cytokinin and auxin interaction in root stem-cell specification during early embryogenesis. Nature. 2008 Jun 19; 453(7198):1094-7. PMID: 18463635.
    Citations: 207     Fields:    Translation:AnimalsCells
  58. Yoo SD, Cho YH, Tena G, Xiong Y, Sheen J. Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signalling. Nature. 2008 Feb 14; 451(7180):789-95. PMID: 18273012.
    Citations: 184     Fields:    Translation:AnimalsCells
  59. Ramon M, Rolland F, Sheen J. . Sugar sensing and signaling in Arabidopsis. The Arabidopsis Book. 2008.
  60. Baena-González E, Rolland F, Sheen J. . KIN10/11 are master regulators of the convergent stress transcriptome. In: Photosynthesis. Energy from the Sun: 14th International Congress on Photosynthesis. 2008; 1337-1344.
  61. Sheen J, He P, Shan L, Xiong Y, Tena G, Yoo SD, Cho YH, Boudsocq M, Lee H. . Signaling specificity and complexity of MAPK cascades in plant innate immunity. Biology of Molecular Plant-Microbe Interactions. 2008; 86:1-10.
  62. Chen Z, Agnew JL, Cohen JD, He P, Shan L, Sheen J, Kunkel BN. Pseudomonas syringae type III effector AvrRpt2 alters Arabidopsis thaliana auxin physiology. Proc Natl Acad Sci U S A. 2007 Dec 11; 104(50):20131-6. PMID: 18056646.
    Citations: 94     Fields:    Translation:AnimalsCells
  63. Müller B, Sheen J. Cytokinin signaling pathway. Sci STKE. 2007 Oct 09; 2007(407):cm4. PMID: 17925575.
    Citations: 3     Fields:    Translation:Cells
  64. Müller B, Sheen J. Arabidopsis cytokinin signaling pathway. Sci STKE. 2007 Oct 09; 2007(407):cm5. PMID: 17925576.
    Citations: 30     Fields:    Translation:AnimalsCells
  65. Müller B, Sheen J. Advances in cytokinin signaling. Science. 2007 Oct 05; 318(5847):68-9. PMID: 17916725.
    Citations: 58     Fields:    Translation:AnimalsCells
  66. Xiao F, He P, Abramovitch RB, Dawson JE, Nicholson LK, Sheen J, Martin GB. The N-terminal region of Pseudomonas type III effector AvrPtoB elicits Pto-dependent immunity and has two distinct virulence determinants. Plant J. 2007 Nov; 52(4):595-614. PMID: 17764515.
    Citations: 36     Fields:    Translation:AnimalsCells
  67. Baena-González E, Rolland F, Thevelein JM, Sheen J. A central integrator of transcription networks in plant stress and energy signalling. Nature. 2007 Aug 23; 448(7156):938-42. PMID: 17671505.
    Citations: 441     Fields:    Translation:AnimalsCells
  68. Shan L, He P, Sheen J. Intercepting host MAPK signaling cascades by bacterial type III effectors. . 2007 May 17; 1(3):167-74. PMID: 18005696.
    Citations: 24     Translation:AnimalsCells
  69. He P, Shan L, Sheen J. Elicitation and suppression of microbe-associated molecular pattern-triggered immunity in plant-microbe interactions. Cell Microbiol. 2007 Jun; 9(6):1385-96. PMID: 17451411.
    Citations: 43     Fields:    Translation:AnimalsCells
  70. Sheen J, He P. Nuclear actions in innate immune signaling. Cell. 2007 Mar 09; 128(5):821-3. PMID: 17350565.
    Citations: 6     Fields:    Translation:AnimalsCells
  71. Cho YH, Yoo SD, Sheen J. Glucose signaling through nuclear hexokinase1 complex in Arabidopsis. Plant Signal Behav. 2007 Mar; 2(2):123-4. PMID: 19704756.
    Citations: 10     Fields:    
  72. He P, Shan L, Sheen J. The use of protoplasts to study innate immune responses. Methods Mol Biol. 2007; 354:1-9. PMID: 17172739.
    Citations: 43     Fields:    Translation:AnimalsCells
  73. Yoo SD, Cho YH, Sheen J. Arabidopsis mesophyll protoplasts: a versatile cell system for transient gene expression analysis. Nat Protoc. 2007; 2(7):1565-72. PMID: 17585298.
    Citations: 1321     Fields:    Translation:AnimalsCells
  74. He P, Shan L, Sheen J. Endless Hide-And-Seek: Dynamic Coevolution in Plant-Bacterium Warfare. J. Int. Plant Biol. 2007; 49:105-111.
  75. Cho YH, Yoo SD, Sheen J. Regulatory functions of nuclear hexokinase1 complex in glucose signaling. Cell. 2006 Nov 03; 127(3):579-89. PMID: 17081979.
    Citations: 146     Fields:    Translation:AnimalsCells
  76. He P, Shan L, Lin NC, Martin GB, Kemmerling B, Nürnberger T, Sheen J. Specific bacterial suppressors of MAMP signaling upstream of MAPKKK in Arabidopsis innate immunity. Cell. 2006 May 05; 125(3):563-75. PMID: 16678099.
    Citations: 132     Fields:    Translation:AnimalsCells
  77. Hamel LP, Nicole MC, Sritubtim S, Morency MJ, Ellis M, Ehlting J, Beaudoin N, Barbazuk B, Klessig D, Lee J, Martin G, Mundy J, Ohashi Y, Scheel D, Sheen J, Xing T, Zhang S, Seguin A, Ellis BE. Ancient signals: comparative genomics of plant MAPK and MAPKK gene families. Trends Plant Sci. 2006 Apr; 11(4):192-8. PMID: 16537113.
    Citations: 174     Fields:    Translation:AnimalsCells
  78. Kim HJ, Ryu H, Hong SH, Woo HR, Lim PO, Lee IC, Sheen J, Nam HG, Hwang I. Cytokinin-mediated control of leaf longevity by AHK3 through phosphorylation of ARR2 in Arabidopsis. Proc Natl Acad Sci U S A. 2006 Jan 17; 103(3):814-9. PMID: 16407152.
    Citations: 136     Fields:    Translation:AnimalsCells
  79. Rolland F, Baena-Gonzalez E, Sheen J. Sugar sensing and signaling in plants: conserved and novel mechanisms. Annu Rev Plant Biol. 2006; 57:675-709. PMID: 16669778.
    Citations: 544     Fields:    Translation:AnimalsCells
  80. Rolland F, Sheen J. Sugar sensing and signalling networks in plants. Biochem Soc Trans. 2005 Feb; 33(Pt 1):269-71. PMID: 15667323.
    Citations: 53     Fields:    Translation:AnimalsCells
  81. Rolland F, Sheen J . Sugar sensing and signaling networks in plants. Biochemical Society Transactions. 2005; 33:269-271.
  82. Shou H, Bordallo P, Fan JB, Yeakley JM, Bibikova M, Sheen J, Wang K. Expression of an active tobacco mitogen-activated protein kinase kinase kinase enhances freezing tolerance in transgenic maize. Proc Natl Acad Sci U S A. 2004 Mar 02; 101(9):3298-303. PMID: 14960727.
    Citations: 28     Fields:    Translation:AnimalsCells
  83. Sheen J, Kay S. Exploring new functions and actions of regulatory molecules. Curr. Opin. Plant Biol. 2004; 7:487-490.
  84. Yanagisawa S, Yoo SD, Sheen J. Differential regulation of EIN3 stability by glucose and ethylene signalling in plants. Nature. 2003 Oct 02; 425(6957):521-5. PMID: 14523448.
    Citations: 177     Fields:    Translation:AnimalsCells
  85. Moore B, Zhou L, Rolland F, Hall Q, Cheng WH, Liu YX, Hwang I, Jones T, Sheen J. Role of the Arabidopsis glucose sensor HXK1 in nutrient, light, and hormonal signaling. Science. 2003 Apr 11; 300(5617):332-6. PMID: 12690200.
    Citations: 360     Fields:    Translation:AnimalsCells
  86. León P, Sheen J. Sugar and hormone connections. Trends Plant Sci. 2003 Mar; 8(3):110-6. PMID: 12663220.
    Citations: 167     Fields:    Translation:AnimalsCells
  87. Cheng WH, Endo A, Zhou L, Penney J, Chen HC, Arroyo A, Leon P, Nambara E, Asami T, Seo M, Koshiba T, Sheen J. A unique short-chain dehydrogenase/reductase in Arabidopsis glucose signaling and abscisic acid biosynthesis and functions. Plant Cell. 2002 Nov; 14(11):2723-43. PMID: 12417697.
    Citations: 247     Fields:    Translation:AnimalsCells
  88. Hwang I, Chen HC, Sheen J. Two-component signal transduction pathways in Arabidopsis. Plant Physiol. 2002 Jun; 129(2):500-15. PMID: 12068096.
    Citations: 120     Fields:    Translation:AnimalsCells
  89. Cheng SH, Willmann MR, Chen HC, Sheen J. Calcium signaling through protein kinases. The Arabidopsis calcium-dependent protein kinase gene family. Plant Physiol. 2002 Jun; 129(2):469-85. PMID: 12068094.
    Citations: 211     Fields:    Translation:AnimalsCells
  90. Sheen J. Phosphorelay and transcription control in cytokinin signal transduction. Science. 2002 May 31; 296(5573):1650-2. PMID: 12040183.
    Citations: 26     Fields:    Translation:AnimalsCells
  91. Asai T, Tena G, Plotnikova J, Willmann MR, Chiu WL, Gomez-Gomez L, Boller T, Ausubel FM, Sheen J. MAP kinase signalling cascade in Arabidopsis innate immunity. Nature. 2002 Feb 28; 415(6875):977-83. PMID: 11875555.
    Citations: 794     Fields:    Translation:AnimalsCells
  92. Rolland F, Moore B, Sheen J. Sugar sensing and signaling in plants. Plant Cell. 2002; 14 Suppl:S185-205. PMID: 12045277.
    Citations: 248     Fields:    Translation:AnimalsCells
  93. Sheen J. Signal transduction in maize and Arabidopsis mesophyll protoplasts. Plant Physiol. 2001 Dec; 127(4):1466-75. PMID: 11743090.
    Citations: 223     Fields:    Translation:AnimalsCells
  94. Shen Q, Gomez-Cadenas A, Zhang P, Walker-Simmons MK, Sheen J, Ho TH. Dissection of abscisic acid signal transduction pathways in barley aleurone layers. Plant Mol Biol. 2001 Oct; 47(3):437-48. PMID: 11587514.
    Citations: 15     Fields:    Translation:AnimalsCells
  95. Tena G, Asai T, Chiu WL, Sheen J. Plant mitogen-activated protein kinase signaling cascades. Curr Opin Plant Biol. 2001 Oct; 4(5):392-400. PMID: 11597496.
    Citations: 143     Fields:    Translation:AnimalsCells
  96. Hwang I, Sheen J. Two-component circuitry in Arabidopsis cytokinin signal transduction. Nature. 2001 Sep 27; 413(6854):383-9. PMID: 11574878.
    Citations: 277     Fields:    Translation:AnimalsCells
  97. Cheng SH, Sheen J, Gerrish C, Bolwell GP. Molecular identification of phenylalanine ammonia-lyase as a substrate of a specific constitutively active Arabidopsis CDPK expressed in maize protoplasts. FEBS Lett. 2001 Aug 17; 503(2-3):185-8. PMID: 11513879.
    Citations: 24     Fields:    Translation:AnimalsCells
  98. Kingston RE, Sheen J, Moore D. Isotopic assays for reporter gene activity. Curr Protoc Mol Biol. 2001 May; Chapter 9:Unit9.7A. PMID: 18265285.
    Citations:    Fields:    Translation:Humans
  99. Seidman CE, Struhl K, Sheen J, Jessen T. Introduction of plasmid DNA into cells. Curr Protoc Mol Biol. 2001 May; Chapter 1:Unit1.8. PMID: 18265047.
    Citations: 16     Fields:    Translation:AnimalsCells
  100. Kingston RE, Sheen J, Moore D. Isotopic assays for reporter gene activity. Curr Protoc Pharmacol. 2001 May; Chapter 6:Unit 6.4. PMID: 21965075.
    Citations:    Fields:    Translation:HumansAnimalsCells
  101. Kausch AP, Owen TP, Zachwieja SJ, Flynn AR, Sheen J. Mesophyll-specific, light and metabolic regulation of the C4 PPCZm1 promoter in transgenic maize. Plant Mol Biol. 2001 Jan; 45(1):1-15. PMID: 11247600.
    Citations: 16     Fields:    Translation:AnimalsCells
  102. Xiao W, Sheen J, Jang JC. The role of hexokinase in plant sugar signal transduction and growth and development. Plant Mol Biol. 2000 Nov; 44(4):451-61. PMID: 11197321.
    Citations: 103     Fields:    Translation:AnimalsCells
  103. Asai T, Stone JM, Heard JE, Kovtun Y, Yorgey P, Sheen J, Ausubel FM. Fumonisin B1-induced cell death in arabidopsis protoplasts requires jasmonate-, ethylene-, and salicylate-dependent signaling pathways. Plant Cell. 2000 Oct; 12(10):1823-36. PMID: 11041879.
    Citations: 92     Fields:    Translation:AnimalsCells
  104. Arenas-Huertero F, Arroyo A, Zhou L, Sheen J, León P. Analysis of Arabidopsis glucose insensitive mutants, gin5 and gin6, reveals a central role of the plant hormone ABA in the regulation of plant vegetative development by sugar. Genes Dev. 2000 Aug 15; 14(16):2085-96. PMID: 10950871.
    Citations: 175     Fields:    Translation:AnimalsCells
  105. Jang JC, Fujioka S, Tasaka M, Seto H, Takatsuto S, Ishii A, Aida M, Yoshida S, Sheen J. A critical role of sterols in embryonic patterning and meristem programming revealed by the fackel mutants of Arabidopsis thaliana. Genes Dev. 2000 Jun 15; 14(12):1485-97. PMID: 10859167.
    Citations: 74     Fields:    Translation:HumansAnimalsCells
  106. Kovtun Y, Chiu WL, Tena G, Sheen J. Functional analysis of oxidative stress-activated mitogen-activated protein kinase cascade in plants. Proc Natl Acad Sci U S A. 2000 Mar 14; 97(6):2940-5. PMID: 10717008.
    Citations: 348     Fields:    Translation:AnimalsCells
  107. Sheen J, Zhou L, Jang JC. Sugars as signaling molecules. Curr Opin Plant Biol. 1999 Oct; 2(5):410-8. PMID: 10508760.
    Citations: 120     Fields:    Translation:Cells
  108. Moore Bd, Sheen J. Plant sugar sensing and signaling - a complex reality. Trends Plant Sci. 1999 Jul; 4(7):250. PMID: 10407437.
    Citations: 16     Fields:    
  109. Sheen J. C4 GENE EXPRESSION. Annu Rev Plant Physiol Plant Mol Biol. 1999 Jun; 50:187-217. PMID: 15012208.
    Citations: 81     
  110. Chang CC, Sheen J, Bligny M, Niwa Y, Lerbs-Mache S, Stern DB. Functional analysis of two maize cDNAs encoding T7-like RNA polymerases. Plant Cell. 1999 May; 11(5):911-26. PMID: 10330475.
    Citations: 40     Fields:    Translation:AnimalsCells
  111. Sheen J, Zhou L, Jang JC . Sugars as signaling molecules. Curr. Opin. Plant Biol. 1999; 2:410-418.
  112. Kovtun Y, Chiu WL, Zeng W, Sheen J. Suppression of auxin signal transduction by a MAPK cascade in higher plants. Nature. 1998 Oct 15; 395(6703):716-20. PMID: 9790195.
    Citations: 74     Fields:    Translation:AnimalsCells
  113. Zhou L, Jang JC, Jones TL, Sheen J. Glucose and ethylene signal transduction crosstalk revealed by an Arabidopsis glucose-insensitive mutant. Proc Natl Acad Sci U S A. 1998 Aug 18; 95(17):10294-9. PMID: 9707641.
    Citations: 162     Fields:    Translation:AnimalsCells
  114. Sheen J. Mutational analysis of protein phosphatase 2C involved in abscisic acid signal transduction in higher plants. Proc Natl Acad Sci U S A. 1998 Feb 03; 95(3):975-80. PMID: 9448270.
    Citations: 89     Fields:    Translation:HumansAnimalsCells
  115. Yanagisawa S, Sheen J. Involvement of maize Dof zinc finger proteins in tissue-specific and light-regulated gene expression. Plant Cell. 1998 Jan; 10(1):75-89. PMID: 9477573.
    Citations: 88     Fields:    Translation:AnimalsCells
  116. Saijo Y, Hata S, Sheen J, Izui K. cDNA cloning and prokaryotic expression of maize calcium-dependent protein kinases. Biochim Biophys Acta. 1997 Feb 07; 1350(2):109-14. PMID: 9048876.
    Citations: 13     Fields:    Translation:AnimalsCells
  117. Jang JC, Sheen J . Sugar sensing in higher plants. Trends in Plant Science. 1997; 2:208-214.
  118. Jang JC, León P, Zhou L, Sheen J. Hexokinase as a sugar sensor in higher plants. Plant Cell. 1997 Jan; 9(1):5-19. PMID: 9014361.
    Citations: 240     Fields:    Translation:HumansAnimalsCells
  119. Sheen J. Ca2+-dependent protein kinases and stress signal transduction in plants. Science. 1996 Dec 13; 274(5294):1900-2. PMID: 8943201.
    Citations: 159     Fields:    Translation:AnimalsCells
  120. Chiu W, Niwa Y, Zeng W, Hirano T, Kobayashi H, Sheen J. Engineered GFP as a vital reporter in plants. Curr Biol. 1996 Mar 01; 6(3):325-30. PMID: 8805250.
    Citations: 434     Fields:    Translation:AnimalsCells
  121. Sheen J, Hwang S, Niwa Y, Kobayashi H, Galbraith DW. Green-fluorescent protein as a new vital marker in plant cells. Plant J. 1995 Nov; 8(5):777-84. PMID: 8528289.
    Citations: 83     Fields:    Translation:Animals
  122. Galbraith DW, Lambert GM, Grebenok RJ, Sheen J. Flow cytometric analysis of transgene expression in higher plants: green-fluorescent protein. Methods Cell Biol. 1995; 50:3-14. PMID: 8531802.
    Citations: 7     Fields:    Translation:AnimalsCells
  123. Sheen J. Methods for mesophyll and bundle sheath cell separation. Methods Cell Biol. 1995; 49:305-14. PMID: 8531764.
    Citations: 12     Fields:    Translation:Animals
  124. Jang JC, Sheen J. Sugar sensing in higher plants. Plant Cell. 1994 Nov; 6(11):1665-79. PMID: 7827498.
    Citations: 169     Fields:    Translation:AnimalsCells
  125. Sheen J. Sugar and acetate repression of photosynthetic gene transcription. In US-Japan Binational Seminar on Environmental Stress and Photosynthesis, Physiological and Molecular Approaches. 1994; 53-56.
  126. Sheen J. Feedback control of gene expression. Photosyntheis Reseach. 1994; 39:427-438.
  127. Sheen J. Protein phosphatase activity is required for light-inducible gene expression in maize. EMBO J. 1993 Sep; 12(9):3497-505. PMID: 8253076.
    Citations: 60     Fields:    Translation:AnimalsCells
  128. Schäffner AR, Sheen J. Maize C4 photosynthesis involves differential regulation of phosphoenolpyruvate carboxylase genes. Plant J. 1992 Mar; 2(2):221-32. PMID: 1302051.
    Citations: 31     Fields:    Translation:AnimalsCells
  129. Sheen J, Huang H, Schäffner AR, Leon P, Jang JC. . Sugars, fatty acids, and photosynthetic gene expression. In Research in Photosynthesis IX. 1992; 753-760.
  130. Schäffner AR, Sheen J. Maize rbcS promoter activity depends on sequence elements not found in dicot rbcS promoters. Plant Cell. 1991 Sep; 3(9):997-1012. PMID: 1822995.
    Citations: 43     Fields:    Translation:AnimalsCells
  131. Sheen J. Molecular mechanisms underlying the differential expression of maize pyruvate, orthophosphate dikinase genes. Plant Cell. 1991 Mar; 3(3):225-45. PMID: 1668653.
    Citations: 84     Fields:    Translation:AnimalsCells
  132. Sheen J. Metabolic repression of transcription in higher plants. Plant Cell. 1990 Oct; 2(10):1027-38. PMID: 2136626.
    Citations: 214     Fields:    Translation:AnimalsCells
  133. Sheen J. A simple phase-extraction assay for CAT activity. In Current Protocols in Molecular Biology. 1989; 9:5-8.
  134. Sheen JY, Seed B. Electrolyte gradient gels for DNA sequencing. Biotechniques. 1988 Nov-Dec; 6(10):942-4. PMID: 3273397.
    Citations: 37     Fields:    Translation:Cells
  135. Seed B, Sheen JY. A simple phase-extraction assay for chloramphenicol acyltransferase activity. Gene. 1988 Jul 30; 67(2):271-7. PMID: 3169576.
    Citations: 292     Fields:    Translation:AnimalsCells
  136. Sheen JY, Bogorad L. Differential Expression in Bundle Sheath and Mesophyll Cells of Maize of Genes for Photosystem II Components Encoded by the Plastid Genome. Plant Physiol. 1988 Apr; 86(4):1020-6. PMID: 16666025.
    Citations: 17     Fields:    
  137. Sheen J. High-efficiency transformation by electroporation. In Current Protocols in Molecular Biology. 1988; 8:4-8.
  138. Sheen JY, Bogorad L. Differential expression of C4 pathway genes in mesophyll and bundle sheath cells of greening maize leaves. J Biol Chem. 1987 Aug 25; 262(24):11726-30. PMID: 2442151.
    Citations: 51     Fields:    Translation:Animals
  139. Sheen JY, Sayre RT, Bogorad L. Differential expression of oxygen-evolving polypeptide genes in maize leaf cell types. Plant Mol Biol. 1987 May; 9(3):217-26. PMID: 24276970.
    Citations: 6     Fields:    
  140. Sheen JY, Bogorad L. Regulation of levels of nuclear transcripts for C4 photosynthesis in bundle sheath and mesophyll cells of maize leaves. Plant Mol Biol. 1987 May; 8(3):227-38. PMID: 24301127.
    Citations: 18     Fields:    
  141. Sheen JY, Bogorad L. Expression of the ribulose-1,5-bisphosphate carboxylase large subunit gene and three small subunit genes in two cell types of maize leaves. EMBO J. 1986 Dec 20; 5(13):3417-22. PMID: 16453739.
    Citations: 37     Fields:    
  142. Sheen JY, Bogorad L. Differential expression of six light-harvesting chlorophyll a/b binding protein genes in maize leaf cell types. Proc Natl Acad Sci U S A. 1986 Oct; 83(20):7811-5. PMID: 3532122.
    Citations: 41     Fields:    Translation:AnimalsCells
  143. Sheen JY, Bogorad L. Differential expression of the ribulose bisphosphate carboxylase large subunit gene in bundle sheath and mesophyll cells of developing maize leaves is influenced by light. Plant Physiol. 1985 Dec; 79(4):1072-6. PMID: 16664532.
    Citations: 48     Fields:    
  144. Goldberg ML, Sheen JY, Gehring WJ, Green MM. Unequal crossing-over associated with asymmetrical synapsis between nomadic elements in the Drosophila melanogaster genome. Proc Natl Acad Sci U S A. 1983 Aug; 80(16):5017-21. PMID: 16593354.
    Citations: 57     Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.