Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Jen Sheen, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01GM129093 (SHEEN, JEN) Jul 1, 2018 - May 31, 2022
    Plant Nutrient-Growth Signaling Network
    Role: Principal Investigator
  2. R01GM070567 (SHEEN, JEN) Apr 1, 2004 - Dec 31, 2017
    Signaling mechanisms in plant innate immunity
    Role: Principal Investigator
  3. R01GM060493 (SHEEN, JEN) Sep 1, 2000 - Mar 31, 2019
    Glucose Signaling in Plants
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Meng Y, Zhang N, Li J, Shen X, Sheen J, Xiong Y. TOR kinase, a GPS in the complex nutrient and hormonal signaling networks to guide plant growth and development. J Exp Bot. 2022 11 15; 73(20):7041-7054. PMID: 35781569; PMCID: PMC9664236.
    Citations:    Fields:    
  2. Liu KH, Liu M, Lin Z, Wang ZF, Chen B, Liu C, Guo A, Konishi M, Yanagisawa S, Wagner G, Sheen J. NIN-like protein 7 transcription factor is a plant nitrate sensor. Science. 2022 09 23; 377(6613):1419-1425. PMID: 36137053; PMCID: PMC9628810.
    Citations: 1     Fields:    Translation:Animals
  3. Ye R, Wang M, Du H, Chhajed S, Koh J, Liu KH, Shin J, Wu Y, Shi L, Xu L, Chen S, Zhang Y, Sheen J. Glucose-driven TOR-FIE-PRC2 signalling controls plant development. Nature. 2022 09; 609(7929):986-993. PMID: 36104568; PMCID: PMC9530021.
    Citations: 2     Fields:    Translation:AnimalsCells
  4. Xue H, Meng J, Lei P, Cao Y, An X, Jia M, Li Y, Liu H, Sheen J, Liu X, Yu F. ARF2-PIF5 interaction controls transcriptional reprogramming in the ABS3-mediated plant senescence pathway. EMBO J. 2022 10 04; 41(19):e110988. PMID: 35942625; PMCID: PMC9531305.
    Citations:    Fields:    Translation:Animals
  5. Brunkard JO, Chang C, Mayer BJ, Meyer C, Sheen J. ConducTORs of a Signaling Symphony: Metabolic and Hormone Responses Converge on TOR and EIN2 in plants. Fac Rev. 2022; 11:12. PMID: 35719129; PMCID: PMC9190210.
  6. Lin CS, Hsu CT, Yuan YH, Zheng PX, Wu FH, Cheng QW, Wu YL, Wu TL, Lin S, Yue JJ, Cheng YH, Lin SI, Shih MC, Sheen J, Lin YC. DNA-free CRISPR-Cas9 gene editing of wild tetraploid tomato Solanum peruvianum using protoplast regeneration. Plant Physiol. 2022 03 28; 188(4):1917-1930. PMID: 35088855; PMCID: PMC8968427.
    Citations: 5     Fields:    Translation:AnimalsCells
  7. Jiang W, Bush J, Sheen J. A Versatile and Efficient Plant Protoplast Platform for Genome Editing by Cas9 RNPs. Front Genome Ed. 2021; 3:719190. PMID: 35005700; PMCID: PMC8729822.
    Citations: 2     
  8. Hsu CT, Yuan YH, Lin YC, Lin S, Cheng QW, Wu FH, Sheen J, Shih MC, Lin CS. Efficient and Economical Targeted Insertion in Plant Genomes via Protoplast Regeneration. CRISPR J. 2021 10; 4(5):752-760. PMID: 34569819; PMCID: PMC9639242.
    Citations: 3     Fields:    Translation:AnimalsCells
  9. Li L, Liu KH, Sheen J. Dynamic Nutrient Signaling Networks in Plants. Annu Rev Cell Dev Biol. 2021 10 06; 37:341-367. PMID: 34351784; PMCID: PMC8497281.
    Citations: 6     Fields:    Translation:AnimalsCells
  10. Liu KH, Diener A, Lin Z, Liu C, Sheen J. Primary nitrate responses mediated by calcium signalling and diverse protein phosphorylation. J Exp Bot. 2020 07 25; 71(15):4428-4441. PMID: 31985788.
    Citations: 10     Fields:    Translation:Cells
  11. Maheshwari P, Du H, Sheen J, Assmann SM, Albert R. Model-driven discovery of calcium-related protein-phosphatase inhibition in plant guard cell signaling. PLoS Comput Biol. 2019 10; 15(10):e1007429. PMID: 31658257; PMCID: PMC6837631.
    Citations: 7     Fields:    Translation:AnimalsCells
  12. Ramon M, Dang TVT, Broeckx T, Hulsmans S, Crepin N, Sheen J, Rolland F. Default Activation and Nuclear Translocation of the Plant Cellular Energy Sensor SnRK1 Regulate Metabolic Stress Responses and Development. Plant Cell. 2019 07; 31(7):1614-1632. PMID: 31123051; PMCID: PMC6635846.
    Citations: 25     Fields:    Translation:AnimalsCells
  13. Wu Y, Shi L, Li L, Fu L, Liu Y, Xiong Y, Sheen J. Integration of nutrient, energy, light, and hormone signalling via TOR in plants. J Exp Bot. 2019 04 15; 70(8):2227-2238. PMID: 30715492; PMCID: PMC6463029.
    Citations: 37     Fields:    Translation:AnimalsCells
  14. Jia M, Liu X, Xue H, Wu Y, Shi L, Wang R, Chen Y, Xu N, Zhao J, Shao J, Qi Y, An L, Sheen J, Yu F. Noncanonical ATG8-ABS3 interaction controls senescence in plants. Nat Plants. 2019 02; 5(2):212-224. PMID: 30664732.
    Citations: 17     Fields:    Translation:AnimalsCells
  15. Lee H, Jun YS, Cha OK, Sheen J. Mitogen-activated protein kinases MPK3 and MPK6 are required for stem cell maintenance in the Arabidopsis shoot apical meristem. Plant Cell Rep. 2019 Mar; 38(3):311-319. PMID: 30552452; PMCID: PMC6573032.
    Citations: 10     Fields:    Translation:Cells
  16. Chen GH, Liu MJ, Xiong Y, Sheen J, Wu SH. TOR and RPS6 transmit light signals to enhance protein translation in deetiolating Arabidopsis seedlings. Proc Natl Acad Sci U S A. 2018 12 11; 115(50):12823-12828. PMID: 30482859; PMCID: PMC6294885.
    Citations: 33     Fields:    Translation:AnimalsCells
  17. Shi L, Wu Y, Sheen J. TOR signaling in plants: conservation and innovation. Development. 2018 07 09; 145(13). PMID: 29986898; PMCID: PMC6053665.
    Citations: 50     Fields:    Translation:AnimalsCells
  18. Li Z, Zhang D, Xiong X, Yan B, Xie W, Sheen J, Li JF. A potent Cas9-derived gene activator for plant and mammalian cells. Nat Plants. 2017 Dec; 3(12):930-936. PMID: 29158545; PMCID: PMC5894343.
    Citations: 52     Fields:    Translation:HumansAnimals
  19. Kim HJ, Wu CY, Yu HM, Sheen J, Lee H. Dual CLAVATA3 Peptides in Arabidopsis Shoot Stem Cell Signaling. J Plant Biol. 2017 Oct; 60(5):506-512. PMID: 30310351; PMCID: PMC6176727.
    Citations: 6     
  20. Liu KH, Niu Y, Konishi M, Wu Y, Du H, Sun Chung H, Li L, Boudsocq M, McCormack M, Maekawa S, Ishida T, Zhang C, Shokat K, Yanagisawa S, Sheen J. Discovery of nitrate-CPK-NLP signalling in central nutrient-growth networks. Nature. 2017 05 18; 545(7654):311-316. PMID: 28489820; PMCID: PMC5823009.
    Citations: 110     Fields:    Translation:AnimalsCells
  21. Chung HS, Sheen J. MAPK Assays in Arabidopsis MAMP-PRR Signal Transduction. Methods Mol Biol. 2017; 1578:155-166. PMID: 28220422.
    Citations: 2     Fields:    Translation:AnimalsCells
  22. Li L, Sheen J. Dynamic and diverse sugar signaling. Curr Opin Plant Biol. 2016 10; 33:116-125. PMID: 27423125; PMCID: PMC5050104.
    Citations: 73     Fields:    Translation:AnimalsCells
  23. Xiong Y, Sheen J. Novel links in the plant TOR kinase signaling network. Curr Opin Plant Biol. 2015 Dec; 28:83-91. PMID: 26476687; PMCID: PMC4612364.
    Citations: 50     Fields:    Translation:Cells
  24. Cheng Z, Li JF, Niu Y, Zhang XC, Woody OZ, Xiong Y, Djonovic S, Millet Y, Bush J, McConkey BJ, Sheen J, Ausubel FM. Pathogen-secreted proteases activate a novel plant immune pathway. Nature. 2015 May 14; 521(7551):213-6. PMID: 25731164.
    Citations: 75     Fields:    Translation:AnimalsCells
  25. Li JF, Zhang D, Sheen J. Targeted plant genome editing via the CRISPR/Cas9 technology. Methods Mol Biol. 2015; 1284:239-55. PMID: 25757776.
    Citations: 11     Fields:    Translation:AnimalsCells
  26. Wu HY, Liu KH, Wang YC, Wu JF, Chiu WL, Chen CY, Wu SH, Sheen J, Lai EM. AGROBEST: an efficient Agrobacterium-mediated transient expression method for versatile gene function analyses in Arabidopsis seedlings. Plant Methods. 2014; 10:19. PMID: 24987449.
    Citations: 67     
  27. Sheen J. Master Regulators in Plant Glucose Signaling Networks. J Plant Biol. 2014 Apr; 57(2):67-79. PMID: 25530701; PMCID: PMC4270195.
    Citations: 72     
  28. Li JF, Zhang D, Sheen J. Epitope-tagged protein-based artificial miRNA screens for optimized gene silencing in plants. Nat Protoc. 2014 Apr; 9(4):939-49. PMID: 24675734.
    Citations: 15     Fields:    Translation:AnimalsCells
  29. Xiong Y, Sheen J. The role of target of rapamycin signaling networks in plant growth and metabolism. Plant Physiol. 2014 Feb; 164(2):499-512. PMID: 24385567; PMCID: PMC3912084.
    Citations: 81     Fields:    Translation:AnimalsCells
  30. Li JF, Zhang D, Sheen J. Cas9-based genome editing in Arabidopsis and tobacco. Methods Enzymol. 2014; 546:459-72. PMID: 25398353.
    Citations: 16     Fields:    Translation:AnimalsCells
  31. Hamel LP, Sheen J, Séguin A. Ancient signals: comparative genomics of green plant CDPKs. Trends Plant Sci. 2014 Feb; 19(2):79-89. PMID: 24342084.
    Citations: 54     Fields:    Translation:Animals
  32. Zhou J, Wu S, Chen X, Liu C, Sheen J, Shan L, He P. The Pseudomonas syringae effector HopF2 suppresses Arabidopsis immunity by targeting BAK1. Plant J. 2014 Jan; 77(2):235-45. PMID: 24237140; PMCID: PMC4224013.
    Citations: 44     Fields:    Translation:AnimalsCells
  33. Sheen J. The cytokinin side chain commands shooting. Dev Cell. 2013 Nov 25; 27(4):371-2. PMID: 24286823.
    Citations:    Fields:    Translation:Animals
  34. Li JF, Norville JE, Aach J, McCormack M, Zhang D, Bush J, Church GM, Sheen J. Multiplex and homologous recombination-mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9. Nat Biotechnol. 2013 Aug; 31(8):688-91. PMID: 23929339.
    Citations: 478     Fields:    Translation:AnimalsCells
  35. Xiong Y, Sheen J. Moving beyond translation: glucose-TOR signaling in the transcriptional control of cell cycle. Cell Cycle. 2013 Jul 01; 12(13):1989-90. PMID: 23759578; PMCID: PMC3737295.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  36. Ramon M, Ruelens P, Li Y, Sheen J, Geuten K, Rolland F. The hybrid four-CBS-domain KINß? subunit functions as the canonical ? subunit of the plant energy sensor SnRK1. Plant J. 2013 Jul; 75(1):11-25. PMID: 23551663; PMCID: PMC6599549.
    Citations: 35     Fields:    Translation:AnimalsCells
  37. Li JF, Chung HS, Niu Y, Bush J, McCormack M, Sheen J. Comprehensive protein-based artificial microRNA screens for effective gene silencing in plants. Plant Cell. 2013 May; 25(5):1507-22. PMID: 23645631.
    Citations: 49     Fields:    Translation:AnimalsCells
  38. Xiong Y, McCormack M, Li L, Hall Q, Xiang C, Sheen J. Glucose-TOR signalling reprograms the transcriptome and activates meristems. Nature. 2013 Apr 11; 496(7444):181-6. PMID: 23542588.
    Citations: 237     Fields:    Translation:AnimalsCells
  39. Fukumoto T, Kano A, Ohtani K, Inoue M, Yoshihara A, Izumori K, Tajima S, Shigematsu Y, Tanaka K, Ohkouchi T, Ishida Y, Nishizawa Y, Tada Y, Ichimura K, Gomi K, Yoo SD, Sheen J, Akimitsu K. Phosphorylation of D-allose by hexokinase involved in regulation of OsABF1 expression for growth inhibition in Oryza sativa L. Planta. 2013 May; 237(5):1379-91. PMID: 23397192.
    Citations: 8     Fields:    Translation:AnimalsCells
  40. Gao X, Chen X, Lin W, Chen S, Lu D, Niu Y, Li L, Cheng C, McCormack M, Sheen J, Shan L, He P. Bifurcation of Arabidopsis NLR immune signaling via Ca²?-dependent protein kinases. PLoS Pathog. 2013 Jan; 9(1):e1003127. PMID: 23382673.
    Citations: 117     Fields:    Translation:AnimalsCells
  41. Cheng C, Gao X, Feng B, Sheen J, Shan L, He P. Plant immune response to pathogens differs with changing temperatures. Nat Commun. 2013; 4:2530. PMID: 24067909.
    Citations: 59     Fields:    Translation:AnimalsCells
  42. Boudsocq M, Sheen J. CDPKs in immune and stress signaling. Trends Plant Sci. 2013 Jan; 18(1):30-40. PMID: 22974587.
    Citations: 179     Fields:    Translation:AnimalsCells
  43. Lee H, Khatri A, Plotnikov JM, Zhang XC, Sheen J. Complexity in differential peptide-receptor signaling: response to Segonzac et Al. and Mueller et Al. commentaries. Plant Cell. 2012 Aug; 24(8):3177-85. PMID: 22923676.
    Citations: 6     Fields:    Translation:Animals
  44. Sheen J. An interview with Jen Sheen. Trends Plant Sci. 2012 Jun; 17(6):321-2. PMID: 22860262.
    Citations:    Fields:    
  45. Liu KH, McCormack M, Sheen J. Targeted parallel sequencing of large genetically-defined genomic regions for identifying mutations in Arabidopsis. Plant Methods. 2012 Mar 30; 8:12. PMID: 22462410.
    Citations: 8     
  46. Hwang I, Sheen J, Müller B. Cytokinin signaling networks. Annu Rev Plant Biol. 2012; 63:353-80. PMID: 22554243.
    Citations: 220     Fields:    Translation:HumansAnimalsCells
  47. Li JF, Sheen J. DNA purification from multiple sources in plant research with homemade silica resins. Methods Mol Biol. 2012; 862:53-9. PMID: 22419488.
    Citations: 3     Fields:    Translation:Cells
  48. Niu Y, Sheen J. Transient expression assays for quantifying signaling output. Methods Mol Biol. 2012; 876:195-206. PMID: 22576097.
    Citations: 8     Fields:    Translation:AnimalsCells
  49. Xiong Y, Sheen J. Rapamycin and glucose-target of rapamycin (TOR) protein signaling in plants. J Biol Chem. 2012 Jan 20; 287(4):2836-42. PMID: 22134914; PMCID: PMC3268441.
    Citations: 99     Fields:    Translation:AnimalsCells
  50. Hamel LP, Benchabane M, Nicole MC, Major IT, Morency MJ, Pelletier G, Beaudoin N, Sheen J, Séguin A. Stress-responsive mitogen-activated protein kinases interact with the EAR motif of a poplar zinc finger protein and mediate its degradation through the 26S proteasome. Plant Physiol. 2011 Nov; 157(3):1379-93. PMID: 21873571.
    Citations: 12     Fields:    Translation:AnimalsCells
  51. Tena G, Boudsocq M, Sheen J. Protein kinase signaling networks in plant innate immunity. Curr Opin Plant Biol. 2011 Oct; 14(5):519-29. PMID: 21704551.
    Citations: 177     Fields:    Translation:AnimalsCells
  52. Lee H, Chah OK, Sheen J. Stem-cell-triggered immunity through CLV3p-FLS2 signalling. Nature. 2011 May 19; 473(7347):376-9. PMID: 21499263.
    Citations: 33     Fields:    Translation:AnimalsCells
  53. Sheen J. Discover and connect cellular signaling. Plant Physiol. 2010 Oct; 154(2):562-6. PMID: 20921185.
    Citations: 7     Fields:    Translation:AnimalsCells
  54. Boudsocq M, Willmann MR, McCormack M, Lee H, Shan L, He P, Bush J, Cheng SH, Sheen J. Differential innate immune signalling via Ca(2+) sensor protein kinases. Nature. 2010 Mar 18; 464(7287):418-22. PMID: 20164835.
    Citations: 321     Fields:    Translation:AnimalsCells
  55. Li JF, Li L, Sheen J. Protocol: a rapid and economical procedure for purification of plasmid or plant DNA with diverse applications in plant biology. Plant Methods. 2010 Jan 14; 6(1):1. PMID: 20180960.
    Citations: 20     
  56. Boudsocq M, Sheen J. . Calcium sensing and signaling. In: Abiotic Stress Adaptation in Plants: Physiological, Molecular and Genomic Foundation. 2010; 75-90.
  57. Cho YH, Sheen J, Yoo SD. Low glucose uncouples hexokinase1-dependent sugar signaling from stress and defense hormone abscisic acid and C2H4 responses in Arabidopsis. Plant Physiol. 2010 Mar; 152(3):1180-2. PMID: 20034964.
    Citations: 32     Fields:    Translation:AnimalsCells
  58. Fujii H, Chinnusamy V, Rodrigues A, Rubio S, Antoni R, Park SY, Cutler SR, Sheen J, Rodriguez PL, Zhu JK. In vitro reconstitution of an abscisic acid signalling pathway. Nature. 2009 Dec 03; 462(7273):660-4. PMID: 19924127.
    Citations: 435     Fields:    Translation:AnimalsCells
  59. Yoo SD, Cho Y, Sheen J. Emerging connections in the ethylene signaling network. Trends Plant Sci. 2009 May; 14(5):270-9. PMID: 19375376.
    Citations: 70     Fields:    Translation:Cells
  60. Cho JI, Ryoo N, Eom JS, Lee DW, Kim HB, Jeong SW, Lee YH, Kwon YK, Cho MH, Bhoo SH, Hahn TR, Park YI, Hwang I, Sheen J, Jeon JS. Role of the rice hexokinases OsHXK5 and OsHXK6 as glucose sensors. Plant Physiol. 2009 Feb; 149(2):745-59. PMID: 19010999.
    Citations: 65     Fields:    Translation:AnimalsCells
  61. Ramon M, Rolland F, Sheen J. Sugar sensing and signaling. Arabidopsis Book. 2008; 6:e0117. PMID: 22303242.
    Citations: 57     
  62. Yoo SD, Sheen J. MAPK signaling in plant hormone ethylene signal transduction. Plant Signal Behav. 2008 Oct; 3(10):848-9. PMID: 19704518.
    Citations: 13     Fields:    
  63. Baena-González E, Sheen J. Convergent energy and stress signaling. Trends Plant Sci. 2008 Sep; 13(9):474-82. PMID: 18701338; PMCID: PMC3075853.
    Citations: 209     Fields:    Translation:AnimalsCells
  64. Shan L, He P, Li J, Heese A, Peck SC, Nürnberger T, Martin GB, Sheen J. Bacterial effectors target the common signaling partner BAK1 to disrupt multiple MAMP receptor-signaling complexes and impede plant immunity. Cell Host Microbe. 2008 Jul 17; 4(1):17-27. PMID: 18621007; PMCID: PMC2830012.
    Citations: 213     Fields:    Translation:AnimalsCells
  65. Karve A, Rauh BL, Xia X, Kandasamy M, Meagher RB, Sheen J, Moore BD. Expression and evolutionary features of the hexokinase gene family in Arabidopsis. Planta. 2008 Aug; 228(3):411-25. PMID: 18481082.
    Citations: 46     Fields:    Translation:AnimalsCells
  66. Müller B, Sheen J. Cytokinin and auxin interaction in root stem-cell specification during early embryogenesis. Nature. 2008 Jun 19; 453(7198):1094-7. PMID: 18463635.
    Citations: 233     Fields:    Translation:AnimalsCells
  67. Yoo SD, Cho YH, Tena G, Xiong Y, Sheen J. Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signalling. Nature. 2008 Feb 14; 451(7180):789-95. PMID: 18273012.
    Citations: 203     Fields:    Translation:AnimalsCells
  68. Baena-González E, Rolland F, Sheen J. . KIN10/11 are master regulators of the convergent stress transcriptome. In: Photosynthesis. Energy from the Sun: 14th International Congress on Photosynthesis. 2008; 1337-1344.
  69. Sheen J, He P, Shan L, Xiong Y, Tena G, Yoo SD, Cho YH, Boudsocq M, Lee H. . Signaling specificity and complexity of MAPK cascades in plant innate immunity. Biology of Molecular Plant-Microbe Interactions. 2008; 86:1-10.
  70. Ramon M, Rolland F, Sheen J. . Sugar sensing and signaling in Arabidopsis. The Arabidopsis Book. 2008.
  71. Chen Z, Agnew JL, Cohen JD, He P, Shan L, Sheen J, Kunkel BN. Pseudomonas syringae type III effector AvrRpt2 alters Arabidopsis thaliana auxin physiology. Proc Natl Acad Sci U S A. 2007 Dec 11; 104(50):20131-6. PMID: 18056646.
    Citations: 112     Fields:    Translation:AnimalsCells
  72. Müller B, Sheen J. Arabidopsis cytokinin signaling pathway. Sci STKE. 2007 Oct 09; 2007(407):cm5. PMID: 17925576.
    Citations: 34     Fields:    Translation:AnimalsCells
  73. Müller B, Sheen J. Cytokinin signaling pathway. Sci STKE. 2007 Oct 09; 2007(407):cm4. PMID: 17925575.
    Citations: 3     Fields:    Translation:Cells
  74. Müller B, Sheen J. Advances in cytokinin signaling. Science. 2007 Oct 05; 318(5847):68-9. PMID: 17916725.
    Citations: 65     Fields:    Translation:AnimalsCells
  75. Xiao F, He P, Abramovitch RB, Dawson JE, Nicholson LK, Sheen J, Martin GB. The N-terminal region of Pseudomonas type III effector AvrPtoB elicits Pto-dependent immunity and has two distinct virulence determinants. Plant J. 2007 Nov; 52(4):595-614. PMID: 17764515; PMCID: PMC2265002.
    Citations: 39     Fields:    Translation:AnimalsCells
  76. Baena-González E, Rolland F, Thevelein JM, Sheen J. A central integrator of transcription networks in plant stress and energy signalling. Nature. 2007 Aug 23; 448(7156):938-42. PMID: 17671505.
    Citations: 517     Fields:    Translation:AnimalsCells
  77. Shan L, He P, Sheen J. Intercepting host MAPK signaling cascades by bacterial type III effectors. Cell Host Microbe. 2007 May 17; 1(3):167-74. PMID: 18005696.
    Citations: 31     Fields:    Translation:AnimalsCells
  78. He P, Shan L, Sheen J. Elicitation and suppression of microbe-associated molecular pattern-triggered immunity in plant-microbe interactions. Cell Microbiol. 2007 Jun; 9(6):1385-96. PMID: 17451411.
    Citations: 53     Fields:    Translation:AnimalsCells
  79. Sheen J, He P. Nuclear actions in innate immune signaling. Cell. 2007 Mar 09; 128(5):821-3. PMID: 17350565.
    Citations: 6     Fields:    Translation:AnimalsCells
  80. Cho YH, Yoo SD, Sheen J. Glucose signaling through nuclear hexokinase1 complex in Arabidopsis. Plant Signal Behav. 2007 Mar; 2(2):123-4. PMID: 19704756.
    Citations: 10     Fields:    
  81. He P, Shan L, Sheen J. The use of protoplasts to study innate immune responses. Methods Mol Biol. 2007; 354:1-9. PMID: 17172739.
    Citations: 51     Fields:    Translation:AnimalsCells
  82. Yoo SD, Cho YH, Sheen J. Arabidopsis mesophyll protoplasts: a versatile cell system for transient gene expression analysis. Nat Protoc. 2007; 2(7):1565-72. PMID: 17585298.
    Citations: 1710     Fields:    Translation:AnimalsCells
  83. He P, Shan L, Sheen J. Endless Hide-And-Seek: Dynamic Coevolution in Plant-Bacterium Warfare. J. Int. Plant Biol. 2007; 49:105-111.
  84. Cho YH, Yoo SD, Sheen J. Regulatory functions of nuclear hexokinase1 complex in glucose signaling. Cell. 2006 Nov 03; 127(3):579-89. PMID: 17081979.
    Citations: 168     Fields:    Translation:AnimalsCells
  85. He P, Shan L, Lin NC, Martin GB, Kemmerling B, Nürnberger T, Sheen J. Specific bacterial suppressors of MAMP signaling upstream of MAPKKK in Arabidopsis innate immunity. Cell. 2006 May 05; 125(3):563-75. PMID: 16678099.
    Citations: 151     Fields:    Translation:AnimalsCells
  86. Hamel LP, Nicole MC, Sritubtim S, Morency MJ, Ellis M, Ehlting J, Beaudoin N, Barbazuk B, Klessig D, Lee J, Martin G, Mundy J, Ohashi Y, Scheel D, Sheen J, Xing T, Zhang S, Seguin A, Ellis BE. Ancient signals: comparative genomics of plant MAPK and MAPKK gene families. Trends Plant Sci. 2006 Apr; 11(4):192-8. PMID: 16537113.
    Citations: 199     Fields:    Translation:AnimalsCells
  87. Kim HJ, Ryu H, Hong SH, Woo HR, Lim PO, Lee IC, Sheen J, Nam HG, Hwang I. Cytokinin-mediated control of leaf longevity by AHK3 through phosphorylation of ARR2 in Arabidopsis. Proc Natl Acad Sci U S A. 2006 Jan 17; 103(3):814-9. PMID: 16407152; PMCID: PMC1334631.
    Citations: 153     Fields:    Translation:AnimalsCells
  88. Rolland F, Baena-Gonzalez E, Sheen J. Sugar sensing and signaling in plants: conserved and novel mechanisms. Annu Rev Plant Biol. 2006; 57:675-709. PMID: 16669778.
    Citations: 626     Fields:    Translation:AnimalsCells
  89. Rolland F, Sheen J. Sugar sensing and signalling networks in plants. Biochem Soc Trans. 2005 Feb; 33(Pt 1):269-71. PMID: 15667323.
    Citations: 57     Fields:    Translation:AnimalsCells
  90. Rolland F, Sheen J . Sugar sensing and signaling networks in plants. Biochemical Society Transactions. 2005; 33:269-271.
  91. Shou H, Bordallo P, Fan JB, Yeakley JM, Bibikova M, Sheen J, Wang K. Expression of an active tobacco mitogen-activated protein kinase kinase kinase enhances freezing tolerance in transgenic maize. Proc Natl Acad Sci U S A. 2004 Mar 02; 101(9):3298-303. PMID: 14960727; PMCID: PMC365784.
    Citations: 30     Fields:    Translation:AnimalsCells
  92. Sheen J, Kay S. Exploring new functions and actions of regulatory molecules. Curr. Opin. Plant Biol. 2004; 7:487-490.
  93. Yanagisawa S, Yoo SD, Sheen J. Differential regulation of EIN3 stability by glucose and ethylene signalling in plants. Nature. 2003 Oct 02; 425(6957):521-5. PMID: 14523448.
    Citations: 189     Fields:    Translation:AnimalsCells
  94. Moore B, Zhou L, Rolland F, Hall Q, Cheng WH, Liu YX, Hwang I, Jones T, Sheen J. Role of the Arabidopsis glucose sensor HXK1 in nutrient, light, and hormonal signaling. Science. 2003 Apr 11; 300(5617):332-6. PMID: 12690200.
    Citations: 409     Fields:    Translation:AnimalsCells
  95. León P, Sheen J. Sugar and hormone connections. Trends Plant Sci. 2003 Mar; 8(3):110-6. PMID: 12663220.
    Citations: 187     Fields:    Translation:AnimalsCells
  96. Cheng WH, Endo A, Zhou L, Penney J, Chen HC, Arroyo A, Leon P, Nambara E, Asami T, Seo M, Koshiba T, Sheen J. A unique short-chain dehydrogenase/reductase in Arabidopsis glucose signaling and abscisic acid biosynthesis and functions. Plant Cell. 2002 Nov; 14(11):2723-43. PMID: 12417697; PMCID: PMC152723.
    Citations: 277     Fields:    Translation:AnimalsCells
  97. Cheng SH, Willmann MR, Chen HC, Sheen J. Calcium signaling through protein kinases. The Arabidopsis calcium-dependent protein kinase gene family. Plant Physiol. 2002 Jun; 129(2):469-85. PMID: 12068094; PMCID: PMC1540234.
    Citations: 254     Fields:    Translation:AnimalsCells
  98. Hwang I, Chen HC, Sheen J. Two-component signal transduction pathways in Arabidopsis. Plant Physiol. 2002 Jun; 129(2):500-15. PMID: 12068096; PMCID: PMC161668.
    Citations: 133     Fields:    Translation:AnimalsCells
  99. Sheen J. Phosphorelay and transcription control in cytokinin signal transduction. Science. 2002 May 31; 296(5573):1650-2. PMID: 12040183.
    Citations: 28     Fields:    Translation:AnimalsCells
  100. Asai T, Tena G, Plotnikova J, Willmann MR, Chiu WL, Gomez-Gomez L, Boller T, Ausubel FM, Sheen J. MAP kinase signalling cascade in Arabidopsis innate immunity. Nature. 2002 Feb 28; 415(6875):977-83. PMID: 11875555.
    Citations: 922     Fields:    Translation:AnimalsCells
  101. Rolland F, Moore B, Sheen J. Sugar sensing and signaling in plants. Plant Cell. 2002; 14 Suppl:S185-205. PMID: 12045277; PMCID: PMC151255.
    Citations: 285     Fields:    Translation:AnimalsCells
  102. Sheen J. Signal transduction in maize and Arabidopsis mesophyll protoplasts. Plant Physiol. 2001 Dec; 127(4):1466-75. PMID: 11743090; PMCID: PMC1540179.
    Citations: 242     Fields:    Translation:AnimalsCells
  103. Tena G, Asai T, Chiu WL, Sheen J. Plant mitogen-activated protein kinase signaling cascades. Curr Opin Plant Biol. 2001 Oct; 4(5):392-400. PMID: 11597496.
    Citations: 156     Fields:    Translation:AnimalsCells
  104. Shen Q, Gomez-Cadenas A, Zhang P, Walker-Simmons MK, Sheen J, Ho TH. Dissection of abscisic acid signal transduction pathways in barley aleurone layers. Plant Mol Biol. 2001 Oct; 47(3):437-48. PMID: 11587514.
    Citations: 16     Fields:    Translation:AnimalsCells
  105. Hwang I, Sheen J. Two-component circuitry in Arabidopsis cytokinin signal transduction. Nature. 2001 Sep 27; 413(6854):383-9. PMID: 11574878.
    Citations: 318     Fields:    Translation:AnimalsCells
  106. Cheng SH, Sheen J, Gerrish C, Bolwell GP. Molecular identification of phenylalanine ammonia-lyase as a substrate of a specific constitutively active Arabidopsis CDPK expressed in maize protoplasts. FEBS Lett. 2001 Aug 17; 503(2-3):185-8. PMID: 11513879.
    Citations: 27     Fields:    Translation:AnimalsCells
  107. Kingston RE, Sheen J, Moore D. Isotopic assays for reporter gene activity. Curr Protoc Pharmacol. 2001 May; Chapter 6:Unit 6.4. PMID: 21965075.
    Citations:    Fields:    Translation:HumansAnimalsCells
  108. Seidman CE, Struhl K, Sheen J, Jessen T. Introduction of plasmid DNA into cells. Curr Protoc Mol Biol. 2001 May; Chapter 1:Unit1.8. PMID: 18265047.
    Citations: 23     Fields:    Translation:AnimalsCells
  109. Kingston RE, Sheen J, Moore D. Isotopic assays for reporter gene activity. Curr Protoc Mol Biol. 2001 May; Chapter 9:Unit9.7A. PMID: 18265285.
    Citations:    Fields:    Translation:Humans
  110. Kausch AP, Owen TP, Zachwieja SJ, Flynn AR, Sheen J. Mesophyll-specific, light and metabolic regulation of the C4 PPCZm1 promoter in transgenic maize. Plant Mol Biol. 2001 Jan; 45(1):1-15. PMID: 11247600.
    Citations: 20     Fields:    Translation:AnimalsCells
  111. Xiao W, Sheen J, Jang JC. The role of hexokinase in plant sugar signal transduction and growth and development. Plant Mol Biol. 2000 Nov; 44(4):451-61. PMID: 11197321.
    Citations: 115     Fields:    Translation:AnimalsCells
  112. Asai T, Stone JM, Heard JE, Kovtun Y, Yorgey P, Sheen J, Ausubel FM. Fumonisin B1-induced cell death in arabidopsis protoplasts requires jasmonate-, ethylene-, and salicylate-dependent signaling pathways. Plant Cell. 2000 Oct; 12(10):1823-36. PMID: 11041879; PMCID: PMC149122.
    Citations: 103     Fields:    Translation:AnimalsCells
  113. Arenas-Huertero F, Arroyo A, Zhou L, Sheen J, León P. Analysis of Arabidopsis glucose insensitive mutants, gin5 and gin6, reveals a central role of the plant hormone ABA in the regulation of plant vegetative development by sugar. Genes Dev. 2000 Aug 15; 14(16):2085-96. PMID: 10950871; PMCID: PMC316855.
    Citations: 183     Fields:    Translation:AnimalsCells
  114. Jang JC, Fujioka S, Tasaka M, Seto H, Takatsuto S, Ishii A, Aida M, Yoshida S, Sheen J. A critical role of sterols in embryonic patterning and meristem programming revealed by the fackel mutants of Arabidopsis thaliana. Genes Dev. 2000 Jun 15; 14(12):1485-97. PMID: 10859167; PMCID: PMC316687.
    Citations: 77     Fields:    Translation:HumansAnimalsCells
  115. Kovtun Y, Chiu WL, Tena G, Sheen J. Functional analysis of oxidative stress-activated mitogen-activated protein kinase cascade in plants. Proc Natl Acad Sci U S A. 2000 Mar 14; 97(6):2940-5. PMID: 10717008; PMCID: PMC16034.
    Citations: 388     Fields:    Translation:AnimalsCells
  116. Sheen J, Zhou L, Jang JC. Sugars as signaling molecules. Curr Opin Plant Biol. 1999 Oct; 2(5):410-8. PMID: 10508760.
    Citations: 133     Fields:    Translation:Cells
  117. Moore Bd, Sheen J. Plant sugar sensing and signaling - a complex reality. Trends Plant Sci. 1999 Jul; 4(7):250. PMID: 10407437.
    Citations: 17     Fields:    
  118. Sheen J. C4 GENE EXPRESSION. Annu Rev Plant Physiol Plant Mol Biol. 1999 Jun; 50:187-217. PMID: 15012208.
    Citations: 87     
  119. Chang CC, Sheen J, Bligny M, Niwa Y, Lerbs-Mache S, Stern DB. Functional analysis of two maize cDNAs encoding T7-like RNA polymerases. Plant Cell. 1999 May; 11(5):911-26. PMID: 10330475; PMCID: PMC144232.
    Citations: 41     Fields:    Translation:AnimalsCells
  120. Sheen J, Zhou L, Jang JC . Sugars as signaling molecules. Curr. Opin. Plant Biol. 1999; 2:410-418.
  121. Kovtun Y, Chiu WL, Zeng W, Sheen J. Suppression of auxin signal transduction by a MAPK cascade in higher plants. Nature. 1998 Oct 15; 395(6703):716-20. PMID: 9790195.
    Citations: 80     Fields:    Translation:AnimalsCells
  122. Zhou L, Jang JC, Jones TL, Sheen J. Glucose and ethylene signal transduction crosstalk revealed by an Arabidopsis glucose-insensitive mutant. Proc Natl Acad Sci U S A. 1998 Aug 18; 95(17):10294-9. PMID: 9707641; PMCID: PMC21502.
    Citations: 170     Fields:    Translation:AnimalsCells
  123. Sheen J. Mutational analysis of protein phosphatase 2C involved in abscisic acid signal transduction in higher plants. Proc Natl Acad Sci U S A. 1998 Feb 03; 95(3):975-80. PMID: 9448270; PMCID: PMC18643.
    Citations: 94     Fields:    Translation:HumansAnimalsCells
  124. Yanagisawa S, Sheen J. Involvement of maize Dof zinc finger proteins in tissue-specific and light-regulated gene expression. Plant Cell. 1998 Jan; 10(1):75-89. PMID: 9477573; PMCID: PMC143930.
    Citations: 101     Fields:    Translation:AnimalsCells
  125. Saijo Y, Hata S, Sheen J, Izui K. cDNA cloning and prokaryotic expression of maize calcium-dependent protein kinases. Biochim Biophys Acta. 1997 Feb 07; 1350(2):109-14. PMID: 9048876.
    Citations: 13     Fields:    Translation:AnimalsCells
  126. Jang JC, León P, Zhou L, Sheen J. Hexokinase as a sugar sensor in higher plants. Plant Cell. 1997 Jan; 9(1):5-19. PMID: 9014361; PMCID: PMC156897.
    Citations: 260     Fields:    Translation:HumansAnimalsCells
  127. Jang JC, Sheen J . Sugar sensing in higher plants. Trends in Plant Science. 1997; 2:208-214.
  128. Sheen J. Ca2+-dependent protein kinases and stress signal transduction in plants. Science. 1996 Dec 13; 274(5294):1900-2. PMID: 8943201.
    Citations: 171     Fields:    Translation:AnimalsCells
  129. Chiu W, Niwa Y, Zeng W, Hirano T, Kobayashi H, Sheen J. Engineered GFP as a vital reporter in plants. Curr Biol. 1996 Mar 01; 6(3):325-30. PMID: 8805250.
    Citations: 458     Fields:    Translation:AnimalsCells
  130. Sheen J, Hwang S, Niwa Y, Kobayashi H, Galbraith DW. Green-fluorescent protein as a new vital marker in plant cells. Plant J. 1995 Nov; 8(5):777-84. PMID: 8528289.
    Citations: 86     Fields:    Translation:Animals
  131. Sheen J. Methods for mesophyll and bundle sheath cell separation. Methods Cell Biol. 1995; 49:305-14. PMID: 8531764.
    Citations: 12     Fields:    Translation:Animals
  132. Galbraith DW, Lambert GM, Grebenok RJ, Sheen J. Flow cytometric analysis of transgene expression in higher plants: green-fluorescent protein. Methods Cell Biol. 1995; 50:3-14. PMID: 8531802.
    Citations: 8     Fields:    Translation:AnimalsCells
  133. Jang JC, Sheen J. Sugar sensing in higher plants. Plant Cell. 1994 Nov; 6(11):1665-79. PMID: 7827498; PMCID: PMC160552.
    Citations: 179     Fields:    Translation:AnimalsCells
  134. Sheen J. Feedback control of gene expression. Photosyntheis Reseach. 1994; 39:427-438.
  135. Sheen J. Sugar and acetate repression of photosynthetic gene transcription. In US-Japan Binational Seminar on Environmental Stress and Photosynthesis, Physiological and Molecular Approaches. 1994; 53-56.
  136. Sheen J. Protein phosphatase activity is required for light-inducible gene expression in maize. EMBO J. 1993 Sep; 12(9):3497-505. PMID: 8253076; PMCID: PMC413626.
    Citations: 62     Fields:    Translation:AnimalsCells
  137. Schäffner AR, Sheen J. Maize C4 photosynthesis involves differential regulation of phosphoenolpyruvate carboxylase genes. Plant J. 1992 Mar; 2(2):221-32. PMID: 1302051.
    Citations: 33     Fields:    Translation:AnimalsCells
  138. Sheen J, Huang H, Schäffner AR, Leon P, Jang JC. . Sugars, fatty acids, and photosynthetic gene expression. In Research in Photosynthesis IX. 1992; 753-760.
  139. Schäffner AR, Sheen J. Maize rbcS promoter activity depends on sequence elements not found in dicot rbcS promoters. Plant Cell. 1991 Sep; 3(9):997-1012. PMID: 1822995; PMCID: PMC160066.
    Citations: 46     Fields:    Translation:AnimalsCells
  140. Sheen J. Molecular mechanisms underlying the differential expression of maize pyruvate, orthophosphate dikinase genes. Plant Cell. 1991 Mar; 3(3):225-45. PMID: 1668653; PMCID: PMC159995.
    Citations: 90     Fields:    Translation:AnimalsCells
  141. Sheen J. Metabolic repression of transcription in higher plants. Plant Cell. 1990 Oct; 2(10):1027-38. PMID: 2136626; PMCID: PMC159951.
    Citations: 221     Fields:    Translation:AnimalsCells
  142. Sheen J. A simple phase-extraction assay for CAT activity. In Current Protocols in Molecular Biology. 1989; 9:5-8.
  143. Sheen JY, Seed B. Electrolyte gradient gels for DNA sequencing. Biotechniques. 1988 Nov-Dec; 6(10):942-4. PMID: 3273397.
    Citations: 37     Fields:    Translation:Cells
  144. Seed B, Sheen JY. A simple phase-extraction assay for chloramphenicol acyltransferase activity. Gene. 1988 Jul 30; 67(2):271-7. PMID: 3169576.
    Citations: 297     Fields:    Translation:AnimalsCells
  145. Sheen JY, Bogorad L. Differential Expression in Bundle Sheath and Mesophyll Cells of Maize of Genes for Photosystem II Components Encoded by the Plastid Genome. Plant Physiol. 1988 Apr; 86(4):1020-6. PMID: 16666025.
    Citations: 17     Fields:    
  146. Sheen J. High-efficiency transformation by electroporation. In Current Protocols in Molecular Biology. 1988; 8:4-8.
  147. Sheen JY, Bogorad L. Differential expression of C4 pathway genes in mesophyll and bundle sheath cells of greening maize leaves. J Biol Chem. 1987 Aug 25; 262(24):11726-30. PMID: 2442151.
    Citations: 53     Fields:    Translation:Animals
  148. Sheen JY, Bogorad L. Regulation of levels of nuclear transcripts for C4 photosynthesis in bundle sheath and mesophyll cells of maize leaves. Plant Mol Biol. 1987 May; 8(3):227-38. PMID: 24301127.
    Citations: 18     Fields:    
  149. Sheen JY, Sayre RT, Bogorad L. Differential expression of oxygen-evolving polypeptide genes in maize leaf cell types. Plant Mol Biol. 1987 May; 9(3):217-26. PMID: 24276970.
    Citations: 6     Fields:    
  150. Sheen JY, Bogorad L. Expression of the ribulose-1,5-bisphosphate carboxylase large subunit gene and three small subunit genes in two cell types of maize leaves. EMBO J. 1986 Dec 20; 5(13):3417-22. PMID: 16453739; PMCID: PMC1167374.
    Citations: 40     Fields:    
  151. Sheen JY, Bogorad L. Differential expression of six light-harvesting chlorophyll a/b binding protein genes in maize leaf cell types. Proc Natl Acad Sci U S A. 1986 Oct; 83(20):7811-5. PMID: 3532122; PMCID: PMC386812.
    Citations: 41     Fields:    Translation:AnimalsCells
  152. Sheen JY, Bogorad L. Differential expression of the ribulose bisphosphate carboxylase large subunit gene in bundle sheath and mesophyll cells of developing maize leaves is influenced by light. Plant Physiol. 1985 Dec; 79(4):1072-6. PMID: 16664532.
    Citations: 50     Fields:    
  153. Goldberg ML, Sheen JY, Gehring WJ, Green MM. Unequal crossing-over associated with asymmetrical synapsis between nomadic elements in the Drosophila melanogaster genome. Proc Natl Acad Sci U S A. 1983 Aug; 80(16):5017-21. PMID: 16593354; PMCID: PMC384179.
    Citations: 59     Fields:    
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Sheen's Networks
Click the
buttons for more information and interactive visualizations!
Concepts (372)
Co-Authors (14)
Similar People (60)
Same Department 
Physical Neighbors
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.