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profileDavid Emil Reich, D.Phil.

TitleProfessor of Genetics
InstitutionHarvard Medical School
DepartmentGenetics
AddressHarvard Medical School
Department of Genetics, NRB 260
77 Avenue Louis Pasteur
Boston MA 02115
Phone617/432-6548
Fax617/432-6306
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Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01CA165862     (HAIMAN, CHRISTOPHER ALAN)Sep 21, 2012 - Jul 31, 2017
NIH/NCI
Genome-wide sequencing of prostate cancer in men of African ancestry
Role: Co-Principal Investigator

R01GM100233     (PATTERSON, NICK J)May 1, 2012 - Apr 30, 2020
NIH/NIGMS
Advanced Tools for Reconstructing Population History
Role: Co-Principal Investigator

U01HG004168     (REICH, DAVID EMIL)Sep 19, 2006 - Aug 31, 2009
NIH/NHGRI
Population structure in whole-genome disease scans
Role: Principal Investigator

R21DK073818     (REICH, DAVID EMIL)Aug 15, 2006 - Jul 31, 2008
NIH/NIDDK
Building a Latino admixture map &pilot study to find Type 2 Diabetes risk
Role: Principal Investigator

R21AI064519     (REICH, DAVID EMIL)Aug 1, 2006 - Jul 31, 2010
NIH/NIAID
Associating genetic variation to resistance to severe malaria in East Africa
Role: Principal Investigator
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This researcher has shared information about their research resources
in the eagle-i Network. To update or add resource records, contact
eagle-i@hms.harvard.edu.
Reich Laboratory - Software (4)

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Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lazaridis I, Reich D. Failure to replicate a genetic signal for sex bias in the steppe migration into central Europe. Proc Natl Acad Sci U S A. 2017 May 16; 114(20):E3873-E3874. PMID: 28476764.
    View in: PubMed
  2. Moorjani P, Sankararaman S, Fu Q, Przeworski M, Patterson N, Reich D. A genetic method for dating ancient genomes provides a direct estimate of human generation interval in the last 45,000 years. Proc Natl Acad Sci U S A. 2016 May 17; 113(20):5652-7. PMID: 27140627; PMCID: PMC4878468 [Available on 11/17/16].
  3. Wise LA, Palmer JR, Ruiz-Narvaez E, Reich DE, Rosenberg L. Is the observed association between dairy intake and fibroids in African Americans explained by genetic ancestry? Am J Epidemiol. 2013 Oct 01; 178(7):1114-9. PMID: 23825169; PMCID: PMC3857926.
  4. Reich D, Patterson N, Campbell D, Tandon A, Mazieres S, Ray N, Parra MV, Rojas W, Duque C, Mesa N, García LF, Triana O, Blair S, Maestre A, Dib JC, Bravi CM, Bailliet G, Corach D, Hünemeier T, Bortolini MC, Salzano FM, Petzl-Erler ML, Acuña-Alonzo V, Aguilar-Salinas C, Canizales-Quinteros S, Tusié-Luna T, Riba L, Rodríguez-Cruz M, Lopez-Alarcón M, Coral-Vazquez R, Canto-Cetina T, Silva-Zolezzi I, Fernandez-Lopez JC, Contreras AV, Jimenez-Sanchez G, Gómez-Vázquez MJ, Molina J, Carracedo A, Salas A, Gallo C, Poletti G, Witonsky DB, Alkorta-Aranburu G, Sukernik RI, Osipova L, Fedorova SA, Vasquez R, Villena M, Moreau C, Barrantes R, Pauls D, Excoffier L, Bedoya G, Rothhammer F, Dugoujon JM, Larrouy G, Klitz W, Labuda D, Kidd J, Kidd K, Di Rienzo A, Freimer NB, Price AL, Ruiz-Linares A. Reconstructing Native American population history. Nature. 2012 Aug 16; 488(7411):370-4. PMID: 22801491; PMCID: PMC3615710.
  5. Reich D, Patterson N, Kircher M, Delfin F, Nandineni MR, Pugach I, Ko AM, Ko YC, Jinam TA, Phipps ME, Saitou N, Wollstein A, Kayser M, Pääbo S, Stoneking M. Denisova admixture and the first modern human dispersals into Southeast Asia and Oceania. Am J Hum Genet. 2011 Oct 07; 89(4):516-28. PMID: 21944045; PMCID: PMC3188841.
  6. Reich D, Green RE, Kircher M, Krause J, Patterson N, Durand EY, Viola B, Briggs AW, Stenzel U, Johnson PL, Maricic T, Good JM, Marques-Bonet T, Alkan C, Fu Q, Mallick S, Li H, Meyer M, Eichler EE, Stoneking M, Richards M, Talamo S, Shunkov MV, Derevianko AP, Hublin JJ, Kelso J, Slatkin M, Pääbo S. Genetic history of an archaic hominin group from Denisova Cave in Siberia. Nature. 2010 Dec 23; 468(7327):1053-60. PMID: 21179161; PMCID: PMC4306417.
  7. Reich D, Thangaraj K, Patterson N, Price AL, Singh L. Reconstructing Indian population history. Nature. 2009 Sep 24; 461(7263):489-94. PMID: 19779445; PMCID: PMC2842210.
  8. Sun JX, Mullikin JC, Patterson N, Reich DE. Microsatellites are molecular clocks that support accurate inferences about history. Mol Biol Evol. 2009 May; 26(5):1017-27. PMID: 19221007; PMCID: PMC2734136.
  9. Cree BA, Reich DE, Khan O, De Jager PL, Nakashima I, Takahashi T, Bar-Or A, Tong C, Hauser SL, Oksenberg JR. Modification of Multiple Sclerosis Phenotypes by African Ancestry at HLA. Arch Neurol. 2009 Feb; 66(2):226-33. PMID: 19204159; PMCID: PMC4334456.
  10. Reich D, Nalls MA, Kao WH, Akylbekova EL, Tandon A, Patterson N, Mullikin J, Hsueh WC, Cheng CY, Coresh J, Boerwinkle E, Li M, Waliszewska A, Neubauer J, Li R, Leak TS, Ekunwe L, Files JC, Hardy CL, Zmuda JM, Taylor HA, Ziv E, Harris TB, Wilson JG. Reduced neutrophil count in people of African descent is due to a regulatory variant in the Duffy antigen receptor for chemokines gene. PLoS Genet. 2009 Jan; 5(1):e1000360. PMID: 19180233; PMCID: PMC2628742.
  11. Kao WH, Klag MJ, Meoni LA, Reich D, Berthier-Schaad Y, Li M, Coresh J, Patterson N, Tandon A, Powe NR, Fink NE, Sadler JH, Weir MR, Abboud HE, Adler SG, Divers J, Iyengar SK, Freedman BI, Kimmel PL, Knowler WC, Kohn OF, Kramp K, Leehey DJ, Nicholas SB, Pahl MV, Schelling JR, Sedor JR, Thornley-Brown D, Winkler CA, Smith MW, Parekh RS. MYH9 is associated with nondiabetic end-stage renal disease in African Americans. Nat Genet. 2008 Oct; 40(10):1185-92. PMID: 18794854; PMCID: PMC2614692.
  12. Caswell JL, Mallick S, Richter DJ, Neubauer J, Schirmer C, Gnerre S, Reich D. Analysis of chimpanzee history based on genome sequence alignments. PLoS Genet. 2008 Apr 18; 4(4):e1000057. PMID: 18421364; PMCID: PMC2278377.
  13. Price AL, Butler J, Patterson N, Capelli C, Pascali VL, Scarnicci F, Ruiz-Linares A, Groop L, Saetta AA, Korkolopoulou P, Seligsohn U, Waliszewska A, Schirmer C, Ardlie K, Ramos A, Nemesh J, Arbeitman L, Goldstein DB, Reich D, Hirschhorn JN. Discerning the ancestry of European Americans in genetic association studies. PLoS Genet. 2008 Jan; 4(1):e236. PMID: 18208327; PMCID: PMC2211542.
  14. Deo RC, Patterson N, Tandon A, McDonald GJ, Haiman CA, Ardlie K, Henderson BE, Henderson SO, Reich D. A high-density admixture scan in 1,670 African Americans with hypertension. PLoS Genet. 2007 Nov; 3(11):e196. PMID: 18020707; PMCID: PMC2077893.
  15. Keinan A, Mullikin JC, Patterson N, Reich D. Measurement of the human allele frequency spectrum demonstrates greater genetic drift in East Asians than in Europeans. Nat Genet. 2007 Oct; 39(10):1251-5. PMID: 17828266; PMCID: PMC3586588.
  16. Ayodo G, Price AL, Keinan A, Ajwang A, Otieno MF, Orago AS, Patterson N, Reich D. Combining evidence of natural selection with association analysis increases power to detect malaria-resistance variants. Am J Hum Genet. 2007 Aug; 81(2):234-42. PMID: 17668374; PMCID: PMC1950820.
  17. Yu F, Hill RS, Schaffner SF, Sabeti PC, Wang ET, Mignault AA, Ferland RJ, Moyzis RK, Walsh CA, Reich D. Comment on "Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens". Science. 2007 Apr 20; 316(5823):370. PMID: 17446375.
    View in: PubMed
  18. Price AL, Patterson N, Yu F, Cox DR, Waliszewska A, McDonald GJ, Tandon A, Schirmer C, Neubauer J, Bedoya G, Duque C, Villegas A, Bortolini MC, Salzano FM, Gallo C, Mazzotti G, Tello-Ruiz M, Riba L, Aguilar-Salinas CA, Canizales-Quinteros S, Menjivar M, Klitz W, Henderson B, Haiman CA, Winkler C, Tusie-Luna T, Ruiz-Linares A, Reich D. A genomewide admixture map for Latino populations. Am J Hum Genet. 2007 Jun; 80(6):1024-36. PMID: 17503322; PMCID: PMC1867092.
  19. Haiman CA, Patterson N, Freedman ML, Myers SR, Pike MC, Waliszewska A, Neubauer J, Tandon A, Schirmer C, McDonald GJ, Greenway SC, Stram DO, Le Marchand L, Kolonel LN, Frasco M, Wong D, Pooler LC, Ardlie K, Oakley-Girvan I, Whittemore AS, Cooney KA, John EM, Ingles SA, Altshuler D, Henderson BE, Reich D. Multiple regions within 8q24 independently affect risk for prostate cancer. Nat Genet. 2007 May; 39(5):638-44. PMID: 17401364; PMCID: PMC2638766.
  20. Reich D, Patterson N, Ramesh V, De Jager PL, McDonald GJ, Tandon A, Choy E, Hu D, Tamraz B, Pawlikowska L, Wassel-Fyr C, Huntsman S, Waliszewska A, Rossin E, Li R, Garcia M, Reiner A, Ferrell R, Cummings S, Kwok PY, Harris T, Zmuda JM, Ziv E. Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels. Am J Hum Genet. 2007 Apr; 80(4):716-26. PMID: 17357077; PMCID: PMC1852718.
  21. Patterson N, Price AL, Reich D. Population structure and eigenanalysis. PLoS Genet. 2006 Dec; 2(12):e190. PMID: 17194218; PMCID: PMC1713260.
  22. Freedman ML, Haiman CA, Patterson N, McDonald GJ, Tandon A, Waliszewska A, Penney K, Steen RG, Ardlie K, John EM, Oakley-Girvan I, Whittemore AS, Cooney KA, Ingles SA, Altshuler D, Henderson BE, Reich D. Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men. Proc Natl Acad Sci U S A. 2006 Sep 19; 103(38):14068-73. PMID: 16945910; PMCID: PMC1599913.
  23. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet. 2006 Aug; 38(8):904-9. PMID: 16862161.
    View in: PubMed
  24. Patterson N, Richter DJ, Gnerre S, Lander ES, Reich D. Genetic evidence for complex speciation of humans and chimpanzees. Nature. 2006 Jun 29; 441(7097):1103-8. PMID: 16710306.
    View in: PubMed
  25. Bonnen PE, Pe'er I, Plenge RM, Salit J, Lowe JK, Shapero MH, Lifton RP, Breslow JL, Daly MJ, Reich DE, Jones KW, Stoffel M, Altshuler D, Friedman JM. Evaluating potential for whole-genome studies in Kosrae, an isolated population in Micronesia. Nat Genet. 2006 Feb; 38(2):214-7. PMID: 16429162.
    View in: PubMed
  26. Schaffner SF, Foo C, Gabriel S, Reich D, Daly MJ, Altshuler D. Calibrating a coalescent simulation of human genome sequence variation. Genome Res. 2005 Nov; 15(11):1576-83. PMID: 16251467; PMCID: PMC1310645.
  27. Sabeti PC, Walsh E, Schaffner SF, Varilly P, Fry B, Hutcheson HB, Cullen M, Mikkelsen TS, Roy J, Patterson N, Cooper R, Reich D, Altshuler D, O'Brien S, Lander ES. The case for selection at CCR5-Delta32. PLoS Biol. 2005 Nov; 3(11):e378. PMID: 16248677; PMCID: PMC1275522.
  28. Reich D, Patterson N, De Jager PL, McDonald GJ, Waliszewska A, Tandon A, Lincoln RR, DeLoa C, Fruhan SA, Cabre P, Bera O, Semana G, Kelly MA, Francis DA, Ardlie K, Khan O, Cree BA, Hauser SL, Oksenberg JR, Hafler DA. A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility. Nat Genet. 2005 Oct; 37(10):1113-8. PMID: 16186815.
    View in: PubMed
  29. Reich D, Patterson N. Will admixture mapping work to find disease genes? Philos Trans R Soc Lond B Biol Sci. 2005 Aug 29; 360(1460):1605-7. PMID: 16096110; PMCID: PMC1609196.
  30. Winckler W, Myers SR, Richter DJ, Onofrio RC, McDonald GJ, Bontrop RE, McVean GA, Gabriel SB, Reich D, Donnelly P, Altshuler D. Comparison of fine-scale recombination rates in humans and chimpanzees. Science. 2005 Apr 01; 308(5718):107-11. PMID: 15705809.
    View in: PubMed
  31. Bersaglieri T, Sabeti PC, Patterson N, Vanderploeg T, Schaffner SF, Drake JA, Rhodes M, Reich DE, Hirschhorn JN. Genetic signatures of strong recent positive selection at the lactase gene. Am J Hum Genet. 2004 Jun; 74(6):1111-20. PMID: 15114531; PMCID: PMC1182075.
  32. Smith MW, Patterson N, Lautenberger JA, Truelove AL, McDonald GJ, Waliszewska A, Kessing BD, Malasky MJ, Scafe C, Le E, De Jager PL, Mignault AA, Yi Z, De The G, Essex M, Sankale JL, Moore JH, Poku K, Phair JP, Goedert JJ, Vlahov D, Williams SM, Tishkoff SA, Winkler CA, De La Vega FM, Woodage T, Sninsky JJ, Hafler DA, Altshuler D, Gilbert DA, O'Brien SJ, Reich D. A high-density admixture map for disease gene discovery in african americans. Am J Hum Genet. 2004 May; 74(5):1001-13. PMID: 15088270; PMCID: PMC1181963.
  33. Patterson N, Hattangadi N, Lane B, Lohmueller KE, Hafler DA, Oksenberg JR, Hauser SL, Smith MW, O'Brien SJ, Altshuler D, Daly MJ, Reich D. Methods for high-density admixture mapping of disease genes. Am J Hum Genet. 2004 May; 74(5):979-1000. PMID: 15088269; PMCID: PMC1181990.
  34. Freedman ML, Reich D, Penney KL, McDonald GJ, Mignault AA, Patterson N, Gabriel SB, Topol EJ, Smoller JW, Pato CN, Pato MT, Petryshen TL, Kolonel LN, Lander ES, Sklar P, Henderson B, Hirschhorn JN, Altshuler D. Assessing the impact of population stratification on genetic association studies. Nat Genet. 2004 Apr; 36(4):388-93. PMID: 15052270.
    View in: PubMed
  35. Oksenberg JR, Barcellos LF, Cree BA, Baranzini SE, Bugawan TL, Khan O, Lincoln RR, Swerdlin A, Mignot E, Lin L, Goodin D, Erlich HA, Schmidt S, Thomson G, Reich DE, Pericak-Vance MA, Haines JL, Hauser SL. Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans. Am J Hum Genet. 2004 Jan; 74(1):160-7. PMID: 14669136; PMCID: PMC1181903.
  36. Reich DE, Gabriel SB, Altshuler D. Quality and completeness of SNP databases. Nat Genet. 2003 Apr; 33(4):457-8. PMID: 12652301.
    View in: PubMed
  37. Sabeti PC, Reich DE, Higgins JM, Levine HZ, Richter DJ, Schaffner SF, Gabriel SB, Platko JV, Patterson NJ, McDonald GJ, Ackerman HC, Campbell SJ, Altshuler D, Cooper R, Kwiatkowski D, Ward R, Lander ES. Detecting recent positive selection in the human genome from haplotype structure. Nature. 2002 Oct 24; 419(6909):832-7. PMID: 12397357.
    View in: PubMed
  38. Reich DE, Schaffner SF, Daly MJ, McVean G, Mullikin JC, Higgins JM, Richter DJ, Lander ES, Altshuler D. Human genome sequence variation and the influence of gene history, mutation and recombination. Nat Genet. 2002 Sep; 32(1):135-42. PMID: 12161752.
    View in: PubMed
  39. Reich DE, Lander ES. On the allelic spectrum of human disease. Trends Genet. 2001 Sep; 17(9):502-10. PMID: 11525833.
    View in: PubMed
  40. Reich DE, Cargill M, Bolk S, Ireland J, Sabeti PC, Richter DJ, Lavery T, Kouyoumjian R, Farhadian SF, Ward R, Lander ES. Linkage disequilibrium in the human genome. Nature. 2001 May 10; 411(6834):199-204. PMID: 11346797.
    View in: PubMed
  41. Reich DE, Goldstein DB. Detecting association in a case-control study while correcting for population stratification. Genet Epidemiol. 2001 Jan; 20(1):4-16. PMID: 11119293.
    View in: PubMed
  42. Lindblad-Toh K, Winchester E, Daly MJ, Wang DG, Hirschhorn JN, Laviolette JP, Ardlie K, Reich DE, Robinson E, Sklar P, Shah N, Thomas D, Fan JB, Gingeras T, Warrington J, Patil N, Hudson TJ, Lander ES. Large-scale discovery and genotyping of single-nucleotide polymorphisms in the mouse. Nat Genet. 2000 Apr; 24(4):381-6. PMID: 10742102.
    View in: PubMed
  43. Goldstein DB, Reich DE, Bradman N, Usher S, Seligsohn U, Peretz H. Age estimates of two common mutations causing factor XI deficiency: recent genetic drift is not necessary for elevated disease incidence among Ashkenazi Jews. Am J Hum Genet. 1999 Apr; 64(4):1071-5. PMID: 10090892; PMCID: PMC1377831.
  44. Goldstein DB, Roemer GW, Smith DA, Reich DE, Bergman A, Wayne RK. The use of microsatellite variation to infer population structure and demographic history in a natural model system. Genetics. 1999 Feb; 151(2):797-801. PMID: 9927470; PMCID: PMC1460481.
  45. Reich DE, Wayne RK, Goldstein DB. Genetic evidence for a recent origin by hybridization of red wolves. Mol Ecol. 1999 Jan; 8(1):139-44. PMID: 9919703.
    View in: PubMed
  46. Reich DE, Goldstein DB. Genetic evidence for a Paleolithic human population expansion in Africa. Proc Natl Acad Sci U S A. 1998 Jul 07; 95(14):8119-23. PMID: 9653150; PMCID: PMC20939.
  47. Stephens JC, Reich DE, Goldstein DB, Shin HD, Smith MW, Carrington M, Winkler C, Huttley GA, Allikmets R, Schriml L, Gerrard B, Malasky M, Ramos MD, Morlot S, Tzetis M, Oddoux C, di Giovine FS, Nasioulas G, Chandler D, Aseev M, Hanson M, Kalaydjieva L, Glavac D, Gasparini P, Kanavakis E, Claustres M, Kambouris M, Ostrer H, Duff G, Baranov V, Sibul H, Metspalu A, Goldman D, Martin N, Duffy D, Schmidtke J, Estivill X, O'Brien SJ, Dean M. Dating the origin of the CCR5-Delta32 AIDS-resistance allele by the coalescence of haplotypes. Am J Hum Genet. 1998 Jun; 62(6):1507-15. PMID: 9585595; PMCID: PMC1377146.
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