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Nezam Hassan Afdhal, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U01AT003571 (AFDHAL, NEZAM HASSAN) Aug 15, 2006 - Jul 31, 2011
    NIH/NCCIH
    Clinical Center for Phase I/II trials of Silymarin in Chronic Liver Disease
    Role: Principal Investigator
  2. U19AI066313 (SCHUPPAN, DETLEF) Jun 30, 2005 - Nov 28, 2010
    NIH/NIAID
    Determinants of Liver Injury in Chronic Hepatitis C Virus Infection
    Role: Co-Principal Investigator
  3. R21CA108303 (AFDHAL, NEZAM HASSAN) Sep 25, 2003 - Aug 31, 2005
    NIH/NCI
    Proteomics and Biomarkers for Hepatocellular Cancer
    Role: Principal Investigator
  4. U01DK060340 (AFDHAL, NEZAM HASSAN) Aug 21, 2001 - Jun 30, 2006
    NIH/NIDDK
    Antiviral Therapy in African Americans with HCV
    Role: Principal Investigator
  5. R01DK045936 (AFDHAL, NEZAM HASSAN) Jul 15, 1993 - May 31, 2003
    NIH/NIDDK
    PROTEIN LIPID INTERACTIONS IN GALLSTONE PATHOGENESIS
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Muir AJ, Levy C, Janssen HLA, Montano-Loza AJ, Shiffman ML, Caldwell S, Luketic V, Ding D, Jia C, McColgan BJ, McHutchison JG, Subramanian GM, Myers RP, Manns M, Chapman R, Afdhal NH, Goodman Z, Eksteen B, Bowlus CL. Simtuzumab for Primary Sclerosing Cholangitis: Phase 2 Study Results With Insights on the Natural History of the Disease. Hepatology. 2018 Aug 28. PMID: 30153359.
    View in: PubMed
  2. Younossi Z, Stepanova M, Sanyal AJ, Harrison SA, Ratziu V, Abdelmalek MF, Diehl AM, Caldwell S, Shiffman ML, Schall RA, McColgan B, Mani Subramanian G, Myers RP, Muir A, Afdhal NH, Bosch J, Goodman Z. The Conundrum of Cryptogenic Cirrhosis: Adverse Outcomes without Treatment Options. J Hepatol. 2018 Aug 22. PMID: 30144554.
    View in: PubMed
  3. Harrison SA, Abdelmalek MF, Caldwell S, Shiffman ML, Diehl AM, Ghalib R, Lawitz EJ, Rockey DC, Schall RA, Jia C, McColgan BJ, McHutchison JG, Subramanian GM, Myers RP, Younossi Z, Ratziu V, Muir AJ, Afdhal NH, Goodman Z, Bosch J, Sanyal AJ. Simtuzumab Is Ineffective for Patients With Bridging Fibrosis or Compensated Cirrhosis Caused by Nonalcoholic Steatohepatitis. Gastroenterology. 2018 Jul 07. PMID: 29990488.
    View in: PubMed
  4. Leahy J, O'Leary A, Afdhal N, Gray E, Milligan S, Wehmeyer MH, Walsh C. The impact of individual patient data in a network meta-analysis: An investigation into parameter estimation and model selection. Res Synth Methods. 2018 Jun 20. PMID: 29923679.
    View in: PubMed
  5. Babusis D, Curry MP, Kirby B, Park Y, Murakami E, Wang T, Mathias A, Afdhal N, McHutchison JG, Ray AS. Sofosbuvir and Ribavirin Liver Pharmacokinetics in Patients Infected with Hepatitis C Virus. Antimicrob Agents Chemother. 2018 May; 62(5). PMID: 29439971.
    View in: PubMed
  6. Flamm SL, Bacon B, Curry MP, Milligan S, Nwankwo CU, Tsai N, Younossi Z, Afdhal N. Real-world use of elbasvir-grazoprevir in patients with chronic hepatitis C: retrospective analyses from the TRIO network. Aliment Pharmacol Ther. 2018 Jun; 47(11):1511-1522. PMID: 29665097.
    View in: PubMed
  7. El-Sherif O, Jiang ZG, Tapper EB, Huang KC, Zhong A, Osinusi A, Charlton M, Manns M, Afdhal NH, Mukamal K, McHutchison J, Brainard DM, Terrault N, Curry MP. Baseline Factors Associated With Improvements in Decompensated Cirrhosis After Direct-Acting Antiviral Therapy for Hepatitis C Virus Infection. Gastroenterology. 2018 06; 154(8):2111-2121.e8. PMID: 29535028.
    View in: PubMed
  8. Grebely J, Feld JJ, Wyles D, Sulkowski M, Ni L, Llewellyn J, Mir HM, Sajed N, Stamm LM, Hyland RH, McNally J, Brainard DM, Jacobson I, Zeuzem S, Bourlière M, Foster G, Afdhal N, Dore GJ. Sofosbuvir-Based Direct-Acting Antiviral Therapies for HCV in People Receiving Opioid Substitution Therapy: An Analysis of Phase 3 Studies. Open Forum Infect Dis. 2018 Feb; 5(2):ofy001. PMID: 29450210.
    View in: PubMed
  9. Loomba R, Gindin Y, Jiang Z, Lawitz E, Caldwell S, Djedjos CS, Xu R, Chung C, Myers RP, Subramanian GM, Goodman Z, Charlton M, Afdhal NH, Diehl AM. DNA methylation signatures reflect aging in patients with nonalcoholic steatohepatitis. JCI Insight. 2018 Jan 25; 3(2). PMID: 29367468.
    View in: PubMed
  10. Jiang ZG, Sandhu B, Feldbrügge L, Yee EU, Csizmadia E, Mitsuhashi S, Huang J, Afdhal NH, Robson SC, Lai M. Serum Activity of Macrophage-Derived Adenosine Deaminase 2 Is Associated With Liver Fibrosis in Nonalcoholic Fatty Liver Disease. Clin Gastroenterol Hepatol. 2018 Jul; 16(7):1170-1172. PMID: 29170098.
    View in: PubMed
  11. Loomba R, Lawitz E, Mantry PS, Jayakumar S, Caldwell SH, Arnold H, Diehl AM, Djedjos CS, Han L, Myers RP, Subramanian GM, McHutchison JG, Goodman ZD, Afdhal NH, Charlton MR. The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: A randomized, phase 2 trial. Hepatology. 2017 Sep 11. PMID: 28892558.
    View in: PubMed
  12. Curry MP, Tapper EB, Bacon B, Dieterich D, Flamm SL, Guest L, Kowdley KV, Lee Y, Milligan S, Tsai N, Younossi Z, Afdhal NH. Effectiveness of 8- or 12-weeks of ledipasvir and sofosbuvir in real-world treatment-naïve, genotype 1 hepatitis C infected patients. Aliment Pharmacol Ther. 2017 09; 46(5):540-548. PMID: 28691377.
    View in: PubMed
  13. Jones M, Cunningham ME, Wing P, DeSilva S, Challa R, Sheri A, Padmanabhan S, Iyer RP, Korba BE, Afdhal N, Foster GR. SB 9200, a novel agonist of innate immunity, shows potent antiviral activity against resistant HCV variants. J Med Virol. 2017 Sep; 89(9):1620-1628. PMID: 28303593.
    View in: PubMed
  14. Tapper EB, Afdhal NH, Curry MP. Before or After Transplantation? A Review of the Cost Effectiveness of Treating Waitlisted Patients With Hepatitis C. Transplantation. 2017 05; 101(5):933-937. PMID: 28437385.
    View in: PubMed
  15. Tapper EB, Hughes MS, Buti M, Dufour JF, Flamm S, Firdoos S, Curry MP, Afdhal NH. The Optimal Timing of Hepatitis C Therapy in Transplant Eligible Patients With Child B and C Cirrhosis: A Cost-Effectiveness Analysis. Transplantation. 2017 05; 101(5):987-995. PMID: 27495755.
    View in: PubMed
  16. Iriana S, Curry MP, Afdhal NH. Neurologic Manifestations of Hepatitis C Virus Infection. Clin Liver Dis. 2017 08; 21(3):535-542. PMID: 28689591.
    View in: PubMed
  17. Afdhal N, Everson GT, Calleja JL, McCaughan GW, Bosch J, Brainard DM, McHutchison JG, De-Oertel S, An D, Charlton M, Reddy KR, Asselah T, Gane E, Curry MP, Forns X. Effect of viral suppression on hepatic venous pressure gradient in hepatitis C with cirrhosis and portal hypertension. J Viral Hepat. 2017 10; 24(10):823-831. PMID: 28295923.
    View in: PubMed
  18. Jacobson IM, Washington MK, Buti M, Thompson A, Afdhal N, Flisiak R, Akarca US, Tchernev KG, Flaherty JF, Aguilar Schall R, Myers RP, Subramanian GM, McHutchison JG, Younossi Z, Marcellin P, Patel K. Factors Associated With Persistent Increase in Level of Alanine Aminotransferase in Patients With Chronic Hepatitis B Receiving Oral Antiviral Therapy. Clin Gastroenterol Hepatol. 2017 Jul; 15(7):1087-1094.e2. PMID: 28215615.
    View in: PubMed
  19. Suresh M, Korolowicz KE, Balarezo M, Iyer RP, Padmanabhan S, Cleary D, Gimi R, Sheri A, Yon C, Kallakury BV, Tucker RD, Afdhal N, Menne S. Antiviral Efficacy and Host Immune Response Induction during Sequential Treatment with SB 9200 Followed by Entecavir in Woodchucks. PLoS One. 2017; 12(1):e0169631. PMID: 28056062.
    View in: PubMed
  20. Wyles D, Dvory-Sobol H, Svarovskaia ES, Doehle BP, Martin R, Afdhal NH, Kowdley KV, Lawitz E, Brainard DM, Miller MD, Mo H, Gane EJ. Post-treatment resistance analysis of hepatitis C virus from phase II and III clinical trials of ledipasvir/sofosbuvir. J Hepatol. 2017 Apr; 66(4):703-710. PMID: 27923693.
    View in: PubMed
  21. Tapper EB, Bacon BR, Curry MP, Dieterich DT, Flamm SL, Guest LE, Kowdley KV, Lee Y, Tsai NC, Younossi ZM, Afdhal NH. Real-world effectiveness for 12 weeks of ledipasvir-sofosbuvir for genotype 1 hepatitis C: the Trio Health study. J Viral Hepat. 2017 01; 24(1):22-27. PMID: 27730717.
    View in: PubMed
  22. Tapper EB, Bacon BR, Curry MP, Dieterich DT, Flamm SL, Guest LE, Kowdley KV, Lee Y, Tsai NC, Younossi ZM, Afdhal NH. Evaluation of proton pump inhibitor use on treatment outcomes with ledipasvir and sofosbuvir in a real-world cohort study. Hepatology. 2016 12; 64(6):1893-1899. PMID: 27533287.
    View in: PubMed
  23. Afdhal NH, Serfaty L. Effect of Registries and Cohort Studies on HCV Treatment. Gastroenterology. 2016 09; 151(3):387-90. PMID: 27456388.
    View in: PubMed
  24. Younossi ZM, Stepanova M, Sulkowski M, Foster GR, Reau N, Mangia A, Patel K, Bräu N, Roberts SK, Afdhal N, Nader F, Henry L, Hunt S. Ribavirin-Free Regimen With Sofosbuvir and Velpatasvir Is Associated With High Efficacy and Improvement of Patient-Reported Outcomes in Patients With Genotypes 2 and 3 Chronic Hepatitis C: Results From Astral-2 and -3 Clinical Trials. Clin Infect Dis. 2016 Oct 15; 63(8):1042-1048. PMID: 27444413.
    View in: PubMed
  25. Jiang ZG, Feldbrügge L, Tapper EB, Popov Y, Ghaziani T, Afdhal N, Robson SC, Mukamal KJ. Letter: would aspirin alleviate fibrosis in alcoholic liver disease? Authors' reply. Aliment Pharmacol Ther. 2016 07; 44(2):209-10. PMID: 27296690.
    View in: PubMed
  26. Sarrazin C, Dvory-Sobol H, Svarovskaia ES, Doehle BP, Pang PS, Chuang SM, Ma J, Ding X, Afdhal NH, Kowdley KV, Gane EJ, Lawitz E, Brainard DM, McHutchison JG, Miller MD, Mo H. Prevalence of Resistance-Associated Substitutions in HCV NS5A, NS5B, or NS3 and Outcomes of Treatment With Ledipasvir and Sofosbuvir. Gastroenterology. 2016 09; 151(3):501-512.e1. PMID: 27296509.
    View in: PubMed
  27. Patwardhan VR, Jiang ZG, Risech-Neiman Y, Piatkowski G, Afdhal NH, Mukamal K, Curry MP, Tapper EB. Serum Ammonia in Associated With Transplant-free Survival in Hospitalized Patients With Acutely Decompensated Cirrhosis. J Clin Gastroenterol. 2016 Apr; 50(4):345-50. PMID: 26565968.
    View in: PubMed
  28. Kaswala DH, Lai M, Afdhal NH. Fibrosis Assessment in Nonalcoholic Fatty Liver Disease (NAFLD) in 2016. Dig Dis Sci. 2016 May; 61(5):1356-64. PMID: 27017224.
    View in: PubMed
  29. Tapper EB, Challies T, Nasser I, Afdhal NH, Lai M. The Performance of Vibration Controlled Transient Elastography in a US Cohort of Patients With Nonalcoholic Fatty Liver Disease. Am J Gastroenterol. 2016 05; 111(5):677-84. PMID: 26977758.
    View in: PubMed
  30. Tapper EB, Sengupta N, Hunink MG, Afdhal NH, Lai M. Erratum: Cost-Effective Evaluation of Nonalcoholic Fatty Liver Disease With NAFLD Fibrosis Score and Vibration-Controlled Transient Elastography. Am J Gastroenterol. 2016 Mar; 111(3):446. PMID: 27018125.
    View in: PubMed
  31. Jiang ZG, Tapper EB, Connelly MA, Pimentel CF, Feldbrügge L, Kim M, Krawczyk S, Afdhal N, Robson SC, Herman MA, Otvos JD, Mukamal KJ, Lai M. Steatohepatitis and liver fibrosis are predicted by the characteristics of very low density lipoprotein in nonalcoholic fatty liver disease. Liver Int. 2016 08; 36(8):1213-20. PMID: 26815314; PMCID: PMC4942367.
  32. Tapper EB, Hunink MG, Afdhal NH, Lai M, Sengupta N. Cost-Effectiveness Analysis: Risk Stratification of Nonalcoholic Fatty Liver Disease (NAFLD) by the Primary Care Physician Using the NAFLD Fibrosis Score. PLoS One. 2016; 11(2):e0147237. PMID: 26905872; PMCID: PMC4764354.
  33. Saab S, Park SH, Mizokami M, Omata M, Mangia A, Eggleton E, Zhu Y, Knox SJ, Pang P, Subramanian M, Kowdley K, Afdhal NH. Safety and efficacy of ledipasvir/sofosbuvir for the treatment of genotype 1 hepatitis C in subjects aged 65 years or older. Hepatology. 2016 Apr; 63(4):1112-9. PMID: 26704693.
    View in: PubMed
  34. Welzel TM, Reddy KR, Flamm SL, Denning J, Lin M, Hyland R, Pang PS, McHutchison JG, Charlton M, Everson GT, Zeuzem S, Afdhal N. On-treatment HCV RNA in patients with varying degrees of fibrosis and cirrhosis in the SOLAR-1 trial. Antivir Ther. 2016; 21(6):541-546. PMID: 26891418.
    View in: PubMed
  35. Jiang ZG, Feldbrügge L, Tapper EB, Popov Y, Ghaziani T, Afdhal N, Robson SC, Mukamal KJ. Aspirin use is associated with lower indices of liver fibrosis among adults in the United States. Aliment Pharmacol Ther. 2016 Mar; 43(6):734-43. PMID: 26749582.
    View in: PubMed
  36. Tapper EB, Catana AM, Sethi N, Mansuri D, Sethi S, Vong A, Afdhal NH. Direct costs of care for hepatocellular carcinoma in patients with hepatitis C cirrhosis. Cancer. 2016 Mar 15; 122(6):852-8. PMID: 26716758.
    View in: PubMed
  37. Wilder JM, Jeffers LJ, Ravendhran N, Shiffman ML, Poulos J, Sulkowski MS, Gitlin N, Workowski K, Zhu Y, Yang JC, Pang PS, McHutchison JG, Muir AJ, Howell C, Kowdley K, Afdhal N, Reddy KR. Safety and efficacy of ledipasvir-sofosbuvir in black patients with hepatitis C virus infection: A retrospective analysis of phase 3 data. Hepatology. 2016 Feb; 63(2):437-44. PMID: 26547499; PMCID: PMC4738375.
  38. Foster GR, Afdhal N, Roberts SK, Bräu N, Gane EJ, Pianko S, Lawitz E, Thompson A, Shiffman ML, Cooper C, Towner WJ, Conway B, Ruane P, Bourlière M, Asselah T, Berg T, Zeuzem S, Rosenberg W, Agarwal K, Stedman CA, Mo H, Dvory-Sobol H, Han L, Wang J, McNally J, Osinusi A, Brainard DM, McHutchison JG, Mazzotta F, Tran TT, Gordon SC, Patel K, Reau N, Mangia A, Sulkowski M. Sofosbuvir and Velpatasvir for HCV Genotype 2 and 3 Infection. N Engl J Med. 2015 Dec 31; 373(27):2608-17. PMID: 26575258.
    View in: PubMed
  39. Pimentel CF, Jiang ZG, Otsubo T, Feldbrügge L, Challies TL, Nasser I, Robson S, Afdhal N, Lai M. Poor Inter-test Reliability Between CK18 Kits as a Biomarker of NASH. Dig Dis Sci. 2016 Mar; 61(3):905-12. PMID: 26462489; PMCID: PMC4761280 [Available on 03/01/17].
  40. Tapper EB, Sengupta N, Hunink MG, Afdhal NH, Lai M. Cost-Effective Evaluation of Nonalcoholic Fatty Liver Disease With NAFLD Fibrosis Score and Vibration Controlled Transient Elastography. Am J Gastroenterol. 2015 Sep; 110(9):1298-304. PMID: 26303130.
    View in: PubMed
  41. Giannini EG, Afdhal NH, Sigal SH, Muir AJ, Reddy KR, Vijayaraghavan S, Elkashab M, Romero-Gómez M, Dusheiko GM, Iyengar M, Vasey SY, Campbell FM, Theodore D. Non-cirrhotic thrombocytopenic patients with hepatitis C virus: Characteristics and outcome of antiviral therapy. J Gastroenterol Hepatol. 2015 Aug; 30(8):1301-8. PMID: 25777337.
    View in: PubMed
  42. Alqahtani SA, Afdhal N, Zeuzem S, Gordon SC, Mangia A, Kwo P, Fried M, Yang JC, Ding X, Pang PS, McHutchison JG, Pound D, Reddy KR, Marcellin P, Kowdley KV, Sulkowski M. Safety and tolerability of ledipasvir/sofosbuvir with and without ribavirin in patients with chronic hepatitis C virus genotype 1 infection: Analysis of phase III ION trials. Hepatology. 2015 Jul; 62(1):25-30. PMID: 25963890.
    View in: PubMed
  43. Jain S, Rajasingham R, Noubary F, Coonahan E, Schoeplein R, Baden R, Curry M, Afdhal N, Kumar S, Pollock NR. Performance of an Optimized Paper-Based Test for Rapid Visual Measurement of Alanine Aminotransferase (ALT) in Fingerstick and Venipuncture Samples. PLoS One. 2015; 10(5):e0128118. PMID: 26020244; PMCID: PMC4447376.
  44. Sethi N, Tapper EB, Vong A, Sethi S, Rourke M, Afdhal NH. Direct costs of first-generation protease inhibitors for the treatment of genotype 1 chronic hepatitis C viral infection. J Viral Hepat. 2015 Dec; 22(12):974-6. PMID: 26010946.
    View in: PubMed
  45. Charlton M, Everson GT, Flamm SL, Kumar P, Landis C, Brown RS, Fried MW, Terrault NA, O'Leary JG, Vargas HE, Kuo A, Schiff E, Sulkowski MS, Gilroy R, Watt KD, Brown K, Kwo P, Pungpapong S, Korenblat KM, Muir AJ, Teperman L, Fontana RJ, Denning J, Arterburn S, Dvory-Sobol H, Brandt-Sarif T, Pang PS, McHutchison JG, Reddy KR, Afdhal N. Ledipasvir and Sofosbuvir Plus Ribavirin for Treatment of HCV Infection in Patients With Advanced Liver Disease. Gastroenterology. 2015 Sep; 149(3):649-59. PMID: 25985734.
    View in: PubMed
  46. Reddy KR, Bourlière M, Sulkowski M, Omata M, Zeuzem S, Feld JJ, Lawitz E, Marcellin P, Welzel TM, Hyland R, Ding X, Yang J, Knox S, Pang P, Dvory-Sobol H, Subramanian GM, Symonds W, McHutchison JG, Mangia A, Gane E, Mizokami M, Pol S, Afdhal N. Ledipasvir and sofosbuvir in patients with genotype 1 hepatitis C virus infection and compensated cirrhosis: An integrated safety and efficacy analysis. Hepatology. 2015 Jul; 62(1):79-86. PMID: 25846144.
    View in: PubMed
  47. Tapper EB, Afdhal NH. Vibration-controlled transient elastography: a practical approach to the noninvasive assessment of liver fibrosis. Curr Opin Gastroenterol. 2015 May; 31(3):192-8. PMID: 25730177.
    View in: PubMed
  48. Jiang ZG, Tsugawa Y, Tapper EB, Lai M, Afdhal N, Robson SC, Mukamal KJ. Low-fasting triglyceride levels are associated with non-invasive markers of advanced liver fibrosis among adults in the United States. Aliment Pharmacol Ther. 2015 Jul; 42(1):106-16. PMID: 25913437.
    View in: PubMed
  49. Younossi ZM, Stepanova M, Marcellin P, Afdhal N, Kowdley KV, Zeuzem S, Hunt SL. Treatment with ledipasvir and sofosbuvir improves patient-reported outcomes: Results from the ION-1, -2, and -3 clinical trials. Hepatology. 2015 Jun; 61(6):1798-808. PMID: 25627448.
    View in: PubMed
  50. Younossi ZM, Stepanova M, Afdhal N, Kowdley KV, Zeuzem S, Henry L, Hunt SL, Marcellin P. Improvement of health-related quality of life and work productivity in chronic hepatitis C patients with early and advanced fibrosis treated with ledipasvir and sofosbuvir. J Hepatol. 2015 Aug; 63(2):337-45. PMID: 25795586.
    View in: PubMed
  51. Buti M, Fung S, Gane E, Afdhal NH, Flisiak R, Gurel S, Flaherty JF, Martins EB, Yee LJ, Dinh P, Bornstein JD, Mani Subramanian G, Janssen HL, George J, Marcellin P. Long-term clinical outcomes in cirrhotic chronic hepatitis B patients treated with tenofovir disoproxil fumarate for up to 5 years. Hepatol Int. 2015 Apr; 9(2):243-50. PMID: 25788199; PMCID: PMC4387268.
  52. Foster G, Afdhal NH, Karayiannis P, Thursz M. Welcome to the new, all electronic Journal of Viral Hepatitis. J Viral Hepat. 2015 Jan; 22(1):1. PMID: 25535958.
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  53. Afdhal NH, Bacon BR, Patel K, Lawitz EJ, Gordon SC, Nelson DR, Challies TL, Nasser I, Garg J, Wei LJ, McHutchison JG. Accuracy of fibroscan, compared with histology, in analysis of liver fibrosis in patients with hepatitis B or C: a United States multicenter study. Clin Gastroenterol Hepatol. 2015 Apr; 13(4):772-9.e1-3. PMID: 25528010.
    View in: PubMed
  54. Afdhal NH. A Fixed-Dose Combination of Sofosbuvir and Ledipasvir for Hepatitis C Virus Genotype 1. Gastroenterol Hepatol (N Y). 2014 Dec; 10(12):815-7. PMID: 27524950; PMCID: PMC4980816.
  55. Bonder A, Tapper EB, Afdhal NH. Contemporary assessment of hepatic fibrosis. Clin Liver Dis. 2015 Feb; 19(1):123-34. PMID: 25454300.
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  56. Curry MP, Forns X, Chung RT, Terrault NA, Brown R, Fenkel JM, Gordon F, O'Leary J, Kuo A, Schiano T, Everson G, Schiff E, Befeler A, Gane E, Saab S, McHutchison JG, Subramanian GM, Symonds WT, Denning J, McNair L, Arterburn S, Svarovskaia E, Moonka D, Afdhal N. Sofosbuvir and ribavirin prevent recurrence of HCV infection after liver transplantation: an open-label study. Gastroenterology. 2015 Jan; 148(1):100-107.e1. PMID: 25261839.
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  57. Patwardhan VR, Sengupta N, Bonder A, Lau D, Afdhal NH. Treatment cessation in noncirrhotic, e-antigen negative chronic hepatitis B is safe and effective following prolonged anti-viral suppression with nucleosides/nucleotides. Aliment Pharmacol Ther. 2014 Oct; 40(7):804-10. PMID: 25109610.
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  58. Tapper EB, Krajewski K, Lai M, Challies T, Kane R, Afdhal N, Lau D. Simple non-invasive biomarkers of advanced fibrosis in the evaluation of non-alcoholic fatty liver disease. Gastroenterol Rep (Oxf). 2014 Nov; 2(4):276-80. PMID: 25002154; PMCID: PMC4219143.
  59. Lin JC, Habersetzer F, Rodriguez-Torres M, Afdhal N, Lawitz EJ, Paulson MS, Zhu Y, Subramanian GM, McHutchison JG, Sulkowski M, Wyles DL, Schooley RT. Interferon ?-induced protein 10 kinetics in treatment-naive versus treatment-experienced patients receiving interferon-free therapy for hepatitis C virus infection: implications for the innate immune response. J Infect Dis. 2014 Dec 15; 210(12):1881-5. PMID: 24907384; PMCID: PMC4296177.
  60. Tapper EB, Castera L, Afdhal NH. FibroScan (vibration-controlled transient elastography): where does it stand in the United States practice. Clin Gastroenterol Hepatol. 2015 Jan; 13(1):27-36. PMID: 24909907.
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  61. Donovan LM, Kress WL, Strnad LC, Sarwar A, Patwardhan V, Piatkowski G, Tapper EB, Afdhal NH. Low likelihood of intracranial hemorrhage in patients with cirrhosis and altered mental status. Clin Gastroenterol Hepatol. 2015 Jan; 13(1):165-9. PMID: 24907500.
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  62. Afdhal NH, Theodore D. Reply: To PMID 24126097. Gastroenterology. 2014 Jul; 147(1):255-6. PMID: 24877870.
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  63. Afdhal N, Zeuzem S, Kwo P, Chojkier M, Gitlin N, Puoti M, Romero-Gomez M, Zarski JP, Agarwal K, Buggisch P, Foster GR, Bräu N, Buti M, Jacobson IM, Subramanian GM, Ding X, Mo H, Yang JC, Pang PS, Symonds WT, McHutchison JG, Muir AJ, Mangia A, Marcellin P. Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection. N Engl J Med. 2014 May 15; 370(20):1889-98. PMID: 24725239.
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  64. Afdhal N, Reddy KR, Nelson DR, Lawitz E, Gordon SC, Schiff E, Nahass R, Ghalib R, Gitlin N, Herring R, Lalezari J, Younes ZH, Pockros PJ, Di Bisceglie AM, Arora S, Subramanian GM, Zhu Y, Dvory-Sobol H, Yang JC, Pang PS, Symonds WT, McHutchison JG, Muir AJ, Sulkowski M, Kwo P. Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection. N Engl J Med. 2014 Apr 17; 370(16):1483-93. PMID: 24725238.
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  65. Foster G, Karayiannis P, Afdhal N. Editorial. J Viral Hepat. 2014 Feb; 21(2):77. PMID: 24383920.
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  66. Bonder A, Afdhal N. Utilization of FibroScan in clinical practice. Curr Gastroenterol Rep. 2014 Feb; 16(2):372. PMID: 24452634.
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  67. Colagreco JP, Bailey DE, Fitzpatrick JJ, Musil CM, Afdhal NH, Lai M. Watchful waiting: role of disease progression on uncertainty and depressive symptoms in patients with chronic hepatitis C. J Viral Hepat. 2014 Oct; 21(10):727-33. PMID: 25280230; PMCID: PMC4185928.
  68. Afdhal NH, Zeuzem S, Schooley RT, Thomas DL, Ward JW, Litwin AH, Razavi H, Castera L, Poynard T, Muir A, Mehta SH, Dee L, Graham C, Church DR, Talal AH, Sulkowski MS, Jacobson IM. The new paradigm of hepatitis C therapy: integration of oral therapies into best practices. J Viral Hepat. 2013 Nov; 20(11):745-60. PMID: 24168254; PMCID: PMC3886291.
  69. Afdhal NH, Dusheiko GM, Giannini EG, Chen PJ, Han KH, Mohsin A, Rodriguez-Torres M, Rugina S, Bakulin I, Lawitz E, Shiffman ML, Tayyab GU, Poordad F, Kamel YM, Brainsky A, Geib J, Vasey SY, Patwardhan R, Campbell FM, Theodore D. Eltrombopag increases platelet numbers in thrombocytopenic patients with HCV infection and cirrhosis, allowing for effective antiviral therapy. Gastroenterology. 2014 Feb; 146(2):442-52.e1. PMID: 24126097.
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  70. Tapper EB, Afdhal NH. Is 3 the new 1: perspectives on virology, natural history and treatment for hepatitis C genotype 3. J Viral Hepat. 2013 Oct; 20(10):669-77. PMID: 24010641.
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  71. Poordad F, Lawitz E, Reddy KR, Afdhal NH, Hézode C, Zeuzem S, Lee SS, Calleja JL, Brown RS, Craxi A, Wedemeyer H, Nyberg L, Nelson DR, Rossaro L, Balart L, Morgan TR, Bacon BR, Flamm SL, Kowdley KV, Deng W, Koury KJ, Pedicone LD, Dutko FJ, Burroughs MH, Alves K, Wahl J, Brass CA, Albrecht JK, Sulkowski MS. Effects of ribavirin dose reduction vs erythropoietin for boceprevir-related anemia in patients with chronic hepatitis C virus genotype 1 infection--a randomized trial. Gastroenterology. 2013 Nov; 145(5):1035-1044.e5. PMID: 23924660.
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  72. Afdhal NH. FibroScan in the Diagnosis of Hepatitis C Virus Infection. Gastroenterol Hepatol (N Y). 2013 Aug; 9(8):533-5. PMID: 24719604; PMCID: PMC3980999.
  73. Lee CK, Perez-Atayde AR, Mitchell PD, Raza R, Afdhal NH, Jonas MM. Serum biomarkers and transient elastography as predictors of advanced liver fibrosis in a United States cohort: the Boston children's hospital experience. J Pediatr. 2013 Oct; 163(4):1058-64.e2. PMID: 23759423.
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  74. McGowan CE, Monis A, Bacon BR, Mallolas J, Goncales FL, Goulis I, Poordad F, Afdhal N, Zeuzem S, Piratvisuth T, Marcellin P, Fried MW. A global view of hepatitis C: physician knowledge, opinions, and perceived barriers to care. Hepatology. 2013 Apr; 57(4):1325-32. PMID: 23315914; PMCID: PMC3683983.
  75. Kowdley KV, Lawitz E, Crespo I, Hassanein T, Davis MN, DeMicco M, Bernstein DE, Afdhal N, Vierling JM, Gordon SC, Anderson JK, Hyland RH, Dvory-Sobol H, An D, Hindes RG, Albanis E, Symonds WT, Berrey MM, Nelson DR, Jacobson IM. Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial. Lancet. 2013 Jun 15; 381(9883):2100-7. PMID: 23499440.
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  76. Lawitz E, Lalezari JP, Hassanein T, Kowdley KV, Poordad FF, Sheikh AM, Afdhal NH, Bernstein DE, Dejesus E, Freilich B, Nelson DR, Dieterich DT, Jacobson IM, Jensen D, Abrams GA, Darling JM, Rodriguez-Torres M, Reddy KR, Sulkowski MS, Bzowej NH, Hyland RH, Mo H, Lin M, Mader M, Hindes R, Albanis E, Symonds WT, Berrey MM, Muir A. Sofosbuvir in combination with peginterferon alfa-2a and ribavirin for non-cirrhotic, treatment-naive patients with genotypes 1, 2, and 3 hepatitis C infection: a randomised, double-blind, phase 2 trial. Lancet Infect Dis. 2013 May; 13(5):401-8. PMID: 23499158.
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  77. Giannini EG, Afdhal NH. Eltrombopag in patients with chronic liver disease. Expert Opin Pharmacother. 2013 Apr; 14(5):669-78. PMID: 23452139.
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  78. Sulkowski MS, Poordad F, Manns MP, Bronowicki JP, Rajender Reddy K, Harrison SA, Afdhal NH, Sings HL, Pedicone LD, Koury KJ, Sniukiene V, Burroughs MH, Albrecht JK, Brass CA, Jacobson IM. Anemia during treatment with peginterferon Alfa-2b/ribavirin and boceprevir: Analysis from the serine protease inhibitor therapy 2 (SPRINT-2) trial. Hepatology. 2013 Mar; 57(3):974-84. PMID: 23081753.
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  79. Bonder A, Afdhal NH. Biopsy no more; changing the screening and diagnostic algorithm for hepatitis C. Clin Gastroenterol Hepatol. 2013 Mar; 11(3):309-10. PMID: 23261413.
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  80. Marcellin P, Gane E, Buti M, Afdhal N, Sievert W, Jacobson IM, Washington MK, Germanidis G, Flaherty JF, Aguilar Schall R, Bornstein JD, Kitrinos KM, Subramanian GM, McHutchison JG, Heathcote EJ. Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study. Lancet. 2013 Feb 09; 381(9865):468-75. PMID: 23234725.
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  81. Li S, Vriend LE, Nasser IA, Popov Y, Afdhal NH, Koziel MJ, Schuppan D, Exley MA, Alatrakchi N. Hepatitis C virus-specific T-cell-derived transforming growth factor beta is associated with slow hepatic fibrogenesis. Hepatology. 2012 Dec; 56(6):2094-105. PMID: 22806830; PMCID: PMC3508175.
  82. Clark PJ, Thompson AJ, Zhu Q, Vock DM, Zhu M, Patel K, Harrison SA, Naggie S, Ge D, Tillmann HL, Urban TJ, Shianna K, Fellay J, Goodman Z, Noviello S, Pedicone LD, Afdhal N, Sulkowski M, Albrecht JK, Goldstein DB, McHutchison JG, Muir AJ. Erratum to: The Association of Genetic Variants with Hepatic Steatosis in Patients with Genotype 1 Chronic Hepatitis C Infection. Dig Dis Sci. 2012 Sep; 57(9):2479. PMID: 22790907.
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  83. Afdhal NH. Fibroscan (transient elastography) for the measurement of liver fibrosis. Gastroenterol Hepatol (N Y). 2012 Sep; 8(9):605-7. PMID: 23483859; PMCID: PMC3594956.
  84. Afdhal NH, Giannini EG, Tayyab G, Mohsin A, Lee JW, Andriulli A, Jeffers L, McHutchison J, Chen PJ, Han KH, Campbell F, Hyde D, Brainsky A, Theodore D. Eltrombopag before procedures in patients with cirrhosis and thrombocytopenia. N Engl J Med. 2012 Aug 23; 367(8):716-24. PMID: 22913681.
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  85. Afdhal NH. Management of nonalcoholic fatty liver disease: a 60-year-old man with probable nonalcoholic fatty liver disease: weight reduction, liver biopsy, or both? JAMA. 2012 Aug 08; 308(6):608-16. PMID: 22760235.
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  86. Fried MW, Navarro VJ, Afdhal N, Belle SH, Wahed AS, Hawke RL, Doo E, Meyers CM, Reddy KR. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. JAMA. 2012 Jul 18; 308(3):274-82. PMID: 22797645; PMCID: PMC3683986.
  87. Lai M, Afdhal NH. Clinical utility of interleukin-28B testing in patients with genotype 1. Hepatology. 2012 Jul; 56(1):367-72. PMID: 22511388.
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  88. Kanwal F, Befeler A, Chari RS, Marrero J, Kahn J, Afdhal N, Morgan T, Roberts L, Mohanty SR, Schwartz J, VanThiel D, Li J, Zeringue A, Di'Bisceglie A. Potentially curative treatment in patients with hepatocellular cancer--results from the liver cancer research network. Aliment Pharmacol Ther. 2012 Aug; 36(3):257-65. PMID: 22670798.
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  89. Jacobson IM, Pawlotsky JM, Afdhal NH, Dusheiko GM, Forns X, Jensen DM, Poordad F, Schulz J. A practical guide for the use of boceprevir and telaprevir for the treatment of hepatitis C. J Viral Hepat. 2012 May; 19 Suppl 2:1-26. PMID: 22404758.
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  90. Bonder A, Afdhal N. Evaluation of liver lesions. Clin Liver Dis. 2012 May; 16(2):271-83. PMID: 22541698.
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  91. Clark PJ, Thompson AJ, Zhu Q, Vock DM, Zhu M, Patel K, Harrison SA, Naggie S, Ge D, Tillmann HL, Urban TJ, Shianna K, Fellay J, Goodman Z, Noviello S, Pedicone LD, Afdhal N, Sulkowski M, Albrecht JK, Goldstein DB, McHutchison JG, Muir AJ. The association of genetic variants with hepatic steatosis in patients with genotype 1 chronic hepatitis C infection. Dig Dis Sci. 2012 Aug; 57(8):2213-21. PMID: 22543885; PMCID: PMC3518927.
  92. Kornek M, Lynch M, Mehta SH, Lai M, Exley M, Afdhal NH, Schuppan D. Circulating microparticles as disease-specific biomarkers of severity of inflammation in patients with hepatitis C or nonalcoholic steatohepatitis. Gastroenterology. 2012 Aug; 143(2):448-58. PMID: 22537612; PMCID: PMC3404266.
  93. Mehta SH, Kirk GD, Astemborski J, Sulkowski MS, Afdhal NH, Thomas DL. Stability of liver fibrosis among HCV-infected injection drug users. Antivir Ther. 2012; 17(5):813-21. PMID: 22418880; PMCID: PMC3699312.
  94. Clark PJ, Thompson AJ, Zhu M, Vock DM, Zhu Q, Ge D, Patel K, Harrison SA, Urban TJ, Naggie S, Fellay J, Tillmann HL, Shianna K, Noviello S, Pedicone LD, Esteban R, Kwo P, Sulkowski MS, Afdhal N, Albrecht JK, Goldstein DB, McHutchison JG, Muir AJ. Interleukin 28B polymorphisms are the only common genetic variants associated with low-density lipoprotein cholesterol (LDL-C) in genotype-1 chronic hepatitis C and determine the association between LDL-C and treatment response. J Viral Hepat. 2012 May; 19(5):332-40. PMID: 22497812; PMCID: PMC3518930.
  95. Tapper EB, Cohen EB, Patel K, Bacon B, Gordon S, Lawitz E, Nelson D, Nasser IA, Challies T, Afdhal N. Levels of alanine aminotransferase confound use of transient elastography to diagnose fibrosis in patients with chronic hepatitis C virus infection. Clin Gastroenterol Hepatol. 2012 Aug; 10(8):932-937.e1. PMID: 22289876; PMCID: PMC3402604.
  96. Lai M, Afdhal NH. Editorial: staging liver fibrosis in hepatitis C: a challenge for this decade. Am J Gastroenterol. 2011 Dec; 106(12):2121-2. PMID: 22138940.
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  97. Martin CR, Blanco PG, Keach JC, Petz JL, Zaman MM, Bhaskar KR, Cluette-Brown JE, Gautam S, Sheth S, Afdhal NH, Lindor KD, Freedman SD. The safety and efficacy of oral docosahexaenoic acid supplementation for the treatment of primary sclerosing cholangitis - a pilot study. Aliment Pharmacol Ther. 2012 Jan; 35(2):255-65. PMID: 22129201; PMCID: PMC3715379.
  98. Reddy KR, Belle SH, Fried MW, Afdhal N, Navarro VJ, Hawke RL, Wahed AS, Doo E, Meyers CM. Rationale, challenges, and participants in a Phase II trial of a botanical product for chronic hepatitis C. Clin Trials. 2012 Feb; 9(1):102-12. PMID: 22058086; PMCID: PMC3293174.
  99. Byrnes V, Miller A, Lowry D, Hill E, Weinstein C, Alsop D, Lenkinski R, Afdhal NH. Effects of anti-viral therapy and HCV clearance on cerebral metabolism and cognition. J Hepatol. 2012 Mar; 56(3):549-56. PMID: 22027578.
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  100. Howell CD, Gorden A, Ryan KA, Thompson AJ, Ibrahim C, Fried M, Afdhal NH, McHutchison JG, Shianna KV, Goldstein DB, Shuldiner AR, Mitchell BD. Single nucleotide polymorphism upstream of interleukin 28B associated with phase 1 and phase 2 of early viral kinetics in patients infected with HCV genotype 1. J Hepatol. 2012 Mar; 56(3):557-63. PMID: 22027585.
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  101. Cárdenas A, Ginès P, Marotta P, Czerwiec F, Oyuang J, Guevara M, Afdhal NH. Tolvaptan, an oral vasopressin antagonist, in the treatment of hyponatremia in cirrhosis. J Hepatol. 2012 Mar; 56(3):571-8. PMID: 22027579.
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  102. Sherman KE, Flamm SL, Afdhal NH, Nelson DR, Sulkowski MS, Everson GT, Fried MW, Adler M, Reesink HW, Martin M, Sankoh AJ, Adda N, Kauffman RS, George S, Wright CI, Poordad F. Response-guided telaprevir combination treatment for hepatitis C virus infection. N Engl J Med. 2011 Sep 15; 365(11):1014-24. PMID: 21916639; PMCID: PMC3809077.
  103. Golden-Mason L, Bambha KM, Cheng L, Howell CD, Taylor MW, Clark PJ, Afdhal N, Rosen HR. Natural killer inhibitory receptor expression associated with treatment failure and interleukin-28B genotype in patients with chronic hepatitis C. Hepatology. 2011 Nov; 54(5):1559-69. PMID: 21983945; PMCID: PMC3206734.
  104. Schrieber SJ, Hawke RL, Wen Z, Smith PC, Reddy KR, Wahed AS, Belle SH, Afdhal NH, Navarro VJ, Meyers CM, Doo E, Fried MW. Differences in the disposition of silymarin between patients with nonalcoholic fatty liver disease and chronic hepatitis C. Drug Metab Dispos. 2011 Dec; 39(12):2182-90. PMID: 21865319; PMCID: PMC3226378.
  105. Klibansky DA, Mehta SH, Curry M, Nasser I, Challies T, Afdhal NH. Transient elastography for predicting clinical outcomes in patients with chronic liver disease. J Viral Hepat. 2012 Feb; 19(2):e184-93. PMID: 22239518.
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  106. Thompson AJ, Clark PJ, Singh A, Ge D, Fellay J, Zhu M, Zhu Q, Urban TJ, Patel K, Tillmann HL, Naggie S, Afdhal NH, Jacobson IM, Esteban R, Poordad F, Lawitz EJ, McCone J, Shiffman ML, Galler GW, King JW, Kwo PY, Shianna KV, Noviello S, Pedicone LD, Brass CA, Albrecht JK, Sulkowski MS, Goldstein DB, McHutchison JG, Muir AJ. Genome-wide association study of interferon-related cytopenia in chronic hepatitis C patients. J Hepatol. 2012 Feb; 56(2):313-9. PMID: 21703177; PMCID: PMC3634361.
  107. Qu KZ, Zhang K, Ma W, Li H, Wang X, Zhang X, Giles F, Lai M, Afdhal NH, Albitar M. Ubiquitin-proteasome profiling for enhanced detection of hepatocellular carcinoma in patients with chronic liver disease. J Gastroenterol Hepatol. 2011 Apr; 26(4):751-8. PMID: 21418304.
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  108. Qu KZ, Zhang K, Li H, Afdhal NH, Albitar M. Circulating microRNAs as biomarkers for hepatocellular carcinoma. J Clin Gastroenterol. 2011 Apr; 45(4):355-60. PMID: 21278583.
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  109. Afdhal NH, Bacon BR, Brown RS. Chronic hepatitis B: integrating long-term treatment data and strategies to improve outcomes in clinical practice. Gastroenterol Hepatol (N Y). 2011 Mar; 7(3 Suppl 4):1-16. PMID: 22557938; PMCID: PMC3337661.
  110. Afdhal NH, McHutchison JG, Zeuzem S, Mangia A, Pawlotsky JM, Murray JS, Shianna KV, Tanaka Y, Thomas DL, Booth DR, Goldstein DB. Hepatitis C pharmacogenetics: state of the art in 2010. Hepatology. 2011 Jan; 53(1):336-45. PMID: 21254181.
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  111. Darling JM, Aerssens J, Fanning G, McHutchison JG, Goldstein DB, Thompson AJ, Shianna KV, Afdhal NH, Hudson ML, Howell CD, Talloen W, Bollekens J, De Wit M, Scholliers A, Fried MW. Quantitation of pretreatment serum interferon-?-inducible protein-10 improves the predictive value of an IL28B gene polymorphism for hepatitis C treatment response. Hepatology. 2011 Jan; 53(1):14-22. PMID: 21254158; PMCID: PMC3083026.
  112. Conjeevaram HS, Wahed AS, Afdhal N, Howell CD, Everhart JE, Hoofnagle JH. Changes in insulin sensitivity and body weight during and after peginterferon and ribavirin therapy for hepatitis C. Gastroenterology. 2011 Feb; 140(2):469-77. PMID: 21070775.
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  113. Kornek M, Popov Y, Libermann TA, Afdhal NH, Schuppan D. Human T cell microparticles circulate in blood of hepatitis patients and induce fibrolytic activation of hepatic stellate cells. Hepatology. 2011 Jan; 53(1):230-42. PMID: 20979056; PMCID: PMC3505073.
  114. Pritchett S, Cardenas A, Manning D, Curry M, Afdhal NH. The optimal cut-off for predicting large oesophageal varices using transient elastography is disease specific. J Viral Hepat. 2011 Apr; 18(4):e75-80. PMID: 21040236.
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  115. Urban TJ, Thompson AJ, Bradrick SS, Fellay J, Schuppan D, Cronin KD, Hong L, McKenzie A, Patel K, Shianna KV, McHutchison JG, Goldstein DB, Afdhal N. IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C. Hepatology. 2010 Dec; 52(6):1888-96. PMID: 20931559; PMCID: PMC3653303.
  116. Cohen EB, Afdhal NH. Ultrasound-based hepatic elastography: origins, limitations, and applications. J Clin Gastroenterol. 2010 Oct; 44(9):637-45. PMID: 20844365.
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  117. Malik R, Lai M, Sadiq A, Farnan R, Mehta S, Nasser I, Challies T, Schuppan D, Afdhal N. Comparison of transient elastography, serum markers and clinical signs for the diagnosis of compensated cirrhosis. J Gastroenterol Hepatol. 2010 Sep; 25(9):1562-8. PMID: 20796156.
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  118. Sulkowski MS, Shiffman ML, Afdhal NH, Reddy KR, McCone J, Lee WM, Herrine SK, Harrison SA, Poordad FF, Koury K, Deng W, Noviello S, Pedicone LD, Brass CA, Albrecht JK, McHutchison JG. Hepatitis C virus treatment-related anemia is associated with higher sustained virologic response rate. Gastroenterology. 2010 Nov; 139(5):1602-11, 1611.e1. PMID: 20723545.
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  119. Schuppan D, Gorrell MD, Klein T, Mark M, Afdhal NH. The challenge of developing novel pharmacological therapies for non-alcoholic steatohepatitis. Liver Int. 2010 Jul; 30(6):795-808. PMID: 20624207.
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  120. Afdhal NH, Curry MP. Early TIPS to improve survival in acute variceal bleeding. N Engl J Med. 2010 Jun 24; 362(25):2421-2. PMID: 20573931.
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  121. Thompson AJ, Fellay J, Patel K, Tillmann HL, Naggie S, Ge D, Urban TJ, Shianna KV, Muir AJ, Fried MW, Afdhal NH, Goldstein DB, McHutchison JG. Variants in the ITPA gene protect against ribavirin-induced hemolytic anemia and decrease the need for ribavirin dose reduction. Gastroenterology. 2010 Oct; 139(4):1181-9. PMID: 20547162; PMCID: PMC3086671.
  122. Wang HH, Portincasa P, Afdhal NH, Wang DQ. Lith genes and genetic analysis of cholesterol gallstone formation. Gastroenterol Clin North Am. 2010 Jun; 39(2):185-207, vii-viii. PMID: 20478482.
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  123. Lai M, Afdhal NH. Health care quality measurement in the care of patients with cirrhosis. Clin Gastroenterol Hepatol. 2010 Aug; 8(8):649-50. PMID: 20478399.
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  124. Thompson AJ, Muir AJ, Sulkowski MS, Ge D, Fellay J, Shianna KV, Urban T, Afdhal NH, Jacobson IM, Esteban R, Poordad F, Lawitz EJ, McCone J, Shiffman ML, Galler GW, Lee WM, Reindollar R, King JW, Kwo PY, Ghalib RH, Freilich B, Nyberg LM, Zeuzem S, Poynard T, Vock DM, Pieper KS, Patel K, Tillmann HL, Noviello S, Koury K, Pedicone LD, Brass CA, Albrecht JK, Goldstein DB, McHutchison JG. Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus. Gastroenterology. 2010 Jul; 139(1):120-9.e18. PMID: 20399780.
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  125. McHutchison JG, Manns MP, Muir AJ, Terrault NA, Jacobson IM, Afdhal NH, Heathcote EJ, Zeuzem S, Reesink HW, Garg J, Bsharat M, George S, Kauffman RS, Adda N, Di Bisceglie AM. Telaprevir for previously treated chronic HCV infection. N Engl J Med. 2010 Apr 08; 362(14):1292-303. PMID: 20375406.
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  126. Poynard T, Afdhal NH. Perspectives on fibrosis progression in hepatitis C: an à la carte approach to risk factors and staging of fibrosis. Antivir Ther. 2010; 15(3):281-91. PMID: 20516548.
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  127. Rustgi VK, Lee WM, Lawitz E, Gordon SC, Afdhal N, Poordad F, Bonkovsky HL, Bengtsson L, Chandorkar G, Harding M, McNair L, Aalyson M, Alam J, Kauffman R, Gharakhanian S, McHutchison JG. Merimepodib, pegylated interferon, and ribavirin in genotype 1 chronic hepatitis C pegylated interferon and ribavirin nonresponders. Hepatology. 2009 Dec; 50(6):1719-26. PMID: 19852040.
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  128. Hawke RL, Schrieber SJ, Soule TA, Wen Z, Smith PC, Reddy KR, Wahed AS, Belle SH, Afdhal NH, Navarro VJ, Berman J, Liu QY, Doo E, Fried MW. Silymarin ascending multiple oral dosing phase I study in noncirrhotic patients with chronic hepatitis C. J Clin Pharmacol. 2010 Apr; 50(4):434-49. PMID: 19841158; PMCID: PMC3086763.
  129. Benhamou Y, Afdhal NH, Nelson DR, Shiffman ML, Halliman DG, Heise J, Chun E, Pockros PJ. A phase III study of the safety and efficacy of viramidine versus ribavirin in treatment-naïve patients with chronic hepatitis C: ViSER1 results. Hepatology. 2009 Sep; 50(3):717-26. PMID: 19585653.
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  130. Celli JP, Turner BS, Afdhal NH, Keates S, Ghiran I, Kelly CP, Ewoldt RH, McKinley GH, So P, Erramilli S, Bansil R. Helicobacter pylori moves through mucus by reducing mucin viscoelasticity. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14321-6. PMID: 19706518; PMCID: PMC2732822.
  131. Becker L, Salameh W, Sferruzza A, Zhang K, ng Chen R, Malik R, Reitz R, Nasser I, Afdhal NH. Validation of hepascore, compared with simple indices of fibrosis, in patients with chronic hepatitis C virus infection in United States. Clin Gastroenterol Hepatol. 2009 Jun; 7(6):696-701. PMID: 19514117.
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  132. Afdhal NH, Lok AS, Di Bisceglie AM. Clinical decisions. Management of incidental hepatitis C virus infection. N Engl J Med. 2009 Apr 30; 360(18):1902-6. PMID: 19403909.
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  133. Malik R, Chang M, Bhaskar K, Nasser I, Curry M, Schuppan D, Byrnes V, Afdhal N. The clinical utility of biomarkers and the nonalcoholic steatohepatitis CRN liver biopsy scoring system in patients with nonalcoholic fatty liver disease. J Gastroenterol Hepatol. 2009 Apr; 24(4):564-8. PMID: 19378390.
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  134. Kirk GD, Astemborski J, Mehta SH, Spoler C, Fisher C, Allen D, Higgins Y, Moore RD, Afdhal N, Torbenson M, Sulkowski M, Thomas DL. Assessment of liver fibrosis by transient elastography in persons with hepatitis C virus infection or HIV-hepatitis C virus coinfection. Clin Infect Dis. 2009 Apr 01; 48(7):963-72. PMID: 19236273; PMCID: PMC2715996.
  135. Manning DS, Afdhal NH. EUS-guided liver biopsy: a procedure looking for an indication. Gastrointest Endosc. 2009 Mar; 69(3 Pt 1):543-5. PMID: 19231496.
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  136. Khokhar A, Afdhal NH. Therapeutic strategies for chronic hepatitis B virus infection in 2008. Am J Med. 2008 Dec; 121(12 Suppl):S33-44. PMID: 19185073.
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  137. Mehta SH, Lau B, Afdhal NH, Thomas DL. Exceeding the limits of liver histology markers. J Hepatol. 2009 Jan; 50(1):36-41. PMID: 19012989; PMCID: PMC2637134.
  138. Popov Y, Zaks J, Grall F, Liebermann T, Afdhal NH, Schuppan D. T Cell Derived Membrane Microparticles containing Emmprin Induce Profibrolytic Activation in Hepatic Stellate Cells. Hepatology. 2008; 46:717A.
  139. Afdhal NH, Manning D. Diagnosis of liver fibrosis in 2008 and beyond. Gastroenterol Clin Biol. 2008 Sep; 32(6 Suppl 1):88-90. PMID: 18973851.
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  140. Li H, Sferruzza A, Qu KZ, Afdhal NH, Lai M, Radcliff JS, Bender RA. Utility of four tumor markers, alone and in combination, for detection of hepatocellular carcinoma: AFP, AFP-L3, DCP, and Cystatin. J Clin Oncol. 2008 May 20; 26(15_suppl):4585. PMID: 27948718.
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  141. Manning DS, Afdhal NH. Diagnosis and quantitation of fibrosis. Gastroenterology. 2008 May; 134(6):1670-81. PMID: 18471546.
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  142. Afdhal NH, Levine R, Brown R Jr.,Freilich B, O'brien M, Brass C. Colchicine Versus Peg-Interferon Alfa 2B long term Therapy: Results of the 4 year copilot trial. Hepatology. 2008; 48:S4.
  143. Malik R, Lai M, BhaskarIN, Curry M, Schuppan D, Afdhal NH. Identification of Biomakers that measure disease activity in patients with nonalcoholic fatty liver disease. Hepatology. 2008; 48:s355.
  144. Afdhal, NH, Manns MP, Lennox JJ, Nguyen T, Berg T, Dalekos GN, Trepo C, Roberts SK, Prieto M, Sorbel J, Anderson J, Mondou E, Rousseau F. The Antiviral Response to Tenofovir Disoproxil Fumarate (TDF) Is Comparable in Lamivudine (LAM)-Naive and LAM-Experienced Subjects treated for chronic Hepatitis B (CHB). Gastroenterology. 2008; 134:A809.
  145. Afdhal N, McHutchison J, Brown R, Jacobson I, Manns M, Poordad F, Weksler B, Esteban R. Thrombocytopenia associated with chronic liver disease. J Hepatol. 2008 Jun; 48(6):1000-7. PMID: 18433919.
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  146. Schuppan D, Afdhal NH. Liver cirrhosis. Lancet. 2008 Mar 08; 371(9615):838-51. PMID: 18328931; PMCID: PMC2271178.
  147. Cardenas A, Lowe R, Oh S, Bodkin S, Kenney T, Lamorte WW, Afdhal NH. Hemodynamic effects of substance P and its receptor antagonist RP67580 in anesthetized rats with carbon tetrachloride-induced cirrhosis. Scand J Gastroenterol. 2008 Mar; 43(3):328-33. PMID: 18938661.
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  148. Zinkin NT, Grall F, Bhaskar K, Otu HH, Spentzos D, Kalmowitz B, Wells M, Guerrero M, Asara JM, Libermann TA, Afdhal NH. Serum proteomics and biomarkers in hepatocellular carcinoma and chronic liver disease. Clin Cancer Res. 2008 Jan 15; 14(2):470-7. PMID: 18223221.
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  149. Patel K, Nelson DR, Rockey DC, Afdhal NH, Smith KM, Oh E, Hettinger K, Vallée M, Dev A, Smith-Riggs M, McHutchison JG. Correlation of FIBROSpect II with histologic and morphometric evaluation of liver fibrosis in chronic hepatitis C. Clin Gastroenterol Hepatol. 2008 Feb; 6(2):242-7. PMID: 18187364.
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  150. Shah NL, Zacharias I, Khettry U, Afdhal N, Gordon FD. Methasteron-associated cholestatic liver injury: clinicopathologic findings in 5 cases. Clin Gastroenterol Hepatol. 2008 Feb; 6(2):255-8. PMID: 18187367.
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  151. Lai M, Afdhal N, Challies T. Liver masses and eosinophilia. Liver Int. 2008 Jan; 28(1):150. PMID: 18173566.
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  152. McHutchison JG, Dusheiko G, Shiffman ML, Rodriguez-Torres M, Sigal S, Bourliere M, Berg T, Gordon SC, Campbell FM, Theodore D, Blackman N, Jenkins J, Afdhal NH. Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C. N Engl J Med. 2007 Nov 29; 357(22):2227-36. PMID: 18046027.
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  153. Afdhal NH, Esteban R. Introduction: thrombocytopenia in chronic liver disease -- treatment implications and novel approaches. Aliment Pharmacol Ther. 2007 Nov; 26 Suppl 1:1-4. PMID: 17958513.
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  154. Afdhal NH, McHutchison JG. Review article: pharmacological approaches for the treatment of thrombocytopenia in patients with chronic liver disease and hepatitis C infection. Aliment Pharmacol Ther. 2007 Nov; 26 Suppl 1:29-39. PMID: 17958517.
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  155. McHutchison JG, Bacon BR, Gordon SC, Lawitz E, Shiffman M, Afdhal NH, Jacobson IM, Muir A, Al-Adhami M, Morris ML, Lekstrom-Himes JA, Efler SM, Davis HL. Phase 1B, randomized, double-blind, dose-escalation trial of CPG 10101 in patients with chronic hepatitis C virus. Hepatology. 2007 Nov; 46(5):1341-9. PMID: 17929306.
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  156. Sulkowski MS, Mehta SH, Torbenson MS, Higgins Y, Brinkley SC, de Oca RM, Moore RD, Afdhal NH, Thomas DL. Rapid fibrosis progression among HIV/hepatitis C virus-co-infected adults. AIDS. 2007 Oct 18; 21(16):2209-16. PMID: 18090048.
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  157. Afdhal NH, McHutchison JG, Shiffman ML, Rodrigues Torres, M, Dusheioko GM, Sigal S, White S, Blackman N, Cambell F, Dickens T. Eltrombopag raises platelet count in 2 weeks in patients with HCv and significant thrombocytopenia. Hepatology. 2007; 46:252A.
  158. Malik R, Afdhal N. Stiffness and impedance: the new liver biomarkers. Clin Gastroenterol Hepatol. 2007 Oct; 5(10):1144-6. PMID: 17916542.
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  159. Shah MB,Brown RS, Barski T, Freilich B, Levine RA, Afdhal NH . Tolerability of low-dose peginterferon alfa-2B in hepatitis C patients with Cirrhosis: Results from the copilot trial. Hepatology. 2007; 46:825A.
  160. Jacobson IM, Brown RS, Freilich B, Afdhal N, Kwo PY, Santoro J, Becker S, Wakil AE, Pound D, Godofsky E, Strauss R, Bernstein D, Flamm S, Pauly MP, Mukhopadhyay P, Griffel LH, Brass CA. Peginterferon alfa-2b and weight-based or flat-dose ribavirin in chronic hepatitis C patients: a randomized trial. Hepatology. 2007 Oct; 46(4):971-81. PMID: 17894303.
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  161. Malik R, Farnan R, Lai M, Freitag H, Schuppan D, Afdhal NH. Comparison of Fibroscan, APRI, AST/ALT and Clinical Signs as non invasive predictors of Cirrhosis. Hepatology. 2007; 46:428A.
  162. Byrnes,VM, Miller, A, Hill,E, Weinstein, david Alsop, Lenkinski, R.E, Afdhal, NH, . The Cerebral Metabolic and Cognitive Effects of Pegylated interferon (PIFN) and Hepatitis C Viral (HCV) Clearance. Hepatology. 2007; 46:380A.
  163. Lai M, Hyatt BJ, Nasser I, Curry M, Afdhal NH. The clinical significance of persistently normal ALT in chronic hepatitis B infection. J Hepatol. 2007 Dec; 47(6):760-7. PMID: 17928090.
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  164. Pockros PJ, Schiff ER, Shiffman ML, McHutchison JG, Gish RG, Afdhal NH, Makhviladze M, Huyghe M, Hecht D, Oltersdorf T, Shapiro DA. Oral IDN-6556, an antiapoptotic caspase inhibitor, may lower aminotransferase activity in patients with chronic hepatitis C. Hepatology. 2007 Aug; 46(2):324-9. PMID: 17654603.
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  165. Lai M, Afdhal NH. Noninvasive markers of Liver fibrosis. Advances in Digestive Diseases. Editor: Howden CW. 2007; 121 - 134.
  166. Byrnes V, Shi H, Kiryu S, Rofsky NM, Afdhal NH. The clinical outcome of small (<20 mm) arterially enhancing nodules on MRI in the cirrhotic liver. Am J Gastroenterol. 2007 Aug; 102(8):1654-9. PMID: 17521396.
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  167. Celli JP, Turner BS, Afdhal NH, Ewoldt RH, McKinley GH, Bansil R, Erramilli S. Rheology of gastric mucin exhibits a pH-dependent sol-gel transition. Biomacromolecules. 2007 May; 8(5):1580-6. PMID: 17402780.
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  168. Goodman ZD, Becker RL, Pockros PJ, Afdhal NH. Progression of fibrosis in advanced chronic hepatitis C: evaluation by morphometric image analysis. Hepatology. 2007 Apr; 45(4):886-94. PMID: 17393526.
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  169. Becker L, Afdhal NH. Nonivasive diagnosis of NASH. Nonalcoholic steatohepatitis (NASH) Editors: Bataller R, Caballeria J. 2007; 111-120.
  170. Pockros PJ, Jeffers L, Afdhal N, Goodman ZD, Nelson D, Gish RG, Reddy KR, Reindollar R, Rodriguez-Torres M, Sullivan S, Blatt LM, Faris-Young S. Final results of a double-blind, placebo-controlled trial of the antifibrotic efficacy of interferon-gamma1b in chronic hepatitis C patients with advanced fibrosis or cirrhosis. Hepatology. 2007 Mar; 45(3):569-78. PMID: 17326152.
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  171. Cárdenas A, Curry M, Afdhal NH. The not so good effects of nitric oxide inhibition with methylene blue in cirrhosis and ascites. Dig Dis Sci. 2007 Apr; 52(4):939-40. PMID: 17308970.
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  172. Afdhal NH, Curry M. Technology evaluation: a critical step in the clinical utilization of novel diagnostic tests for liver fibrosis. J Hepatol. 2007 Apr; 46(4):543-5. PMID: 17316879.
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  173. Esmat G, Metwally M, Zalata KR, Gadalla S, Abdel-Hamid M, Abouzied A, Shaheen AA, El-Raziky M, Khatab H, El-Kafrawy S, Mikhail N, Magder LS, Afdhal NH, Strickland GT. Evaluation of serum biomarkers of fibrosis and injury in Egyptian patients with chronic hepatitis C. J Hepatol. 2007 Apr; 46(4):620-7. PMID: 17316875.
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  174. Conjeevaram HS, Kleiner DE, Everhart JE, Hoofnagle JH, Zacks S, Afdhal NH, Wahed AS. Race, insulin resistance and hepatic steatosis in chronic hepatitis C. Hepatology. 2007 Jan; 45(1):80-7. PMID: 17187406.
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  175. Fontana RJ, Kleiner DE, Bilonick R, Terrault N, Afdhal N, Belle SH, Jeffers LJ, Ramcharran D, Ghany MG, Hoofnagle JH. Modeling hepatic fibrosis in African American and Caucasian American patients with chronic hepatitis C virus infection. Hepatology. 2006 Oct; 44(4):925-35. PMID: 17006909.
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  176. McHutchison J, Poynard T, Afdhal N. Fibrosis as an end point for clinical trials in liver disease: a report of the international fibrosis group. Clin Gastroenterol Hepatol. 2006 Oct; 4(10):1214-1220. PMID: 16979947.
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  177. Conjeevaram HS, Fried MW, Jeffers LJ, Terrault NA, Wiley-Lucas TE, Afdhal N, Brown RS, Belle SH, Hoofnagle JH, Kleiner DE, Howell CD. Peginterferon and ribavirin treatment in African American and Caucasian American patients with hepatitis C genotype 1. Gastroenterology. 2006 Aug; 131(2):470-7. PMID: 16890601.
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  178. Wang HH, Afdhal NH, Gendler SJ, Wang DQ. Evidence that gallbladder epithelial mucin enhances cholesterol cholelithogenesis in MUC1 transgenic mice. Gastroenterology. 2006 Jul; 131(1):210-22. PMID: 16831603.
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  179. Afdhal NH. Noninvasive Markers of Liver Fibrosis. Gastroenterol Hepatol (N Y). 2006 Jun; 2(6):413-415. PMID: 28316514.
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  180. Mueller S, Afdhal NH, Schuppan D. Iron, HCV, and liver cancer: hard metal setting the pace? Gastroenterology. 2006 Jun; 130(7):2229-34. PMID: 16762645.
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  181. Kamal SM, Moustafa KN, Chen J, Fehr J, Abdel Moneim A, Khalifa KE, El Gohary LA, Ramy AH, Madwar MA, Rasenack J, Afdhal NH. Duration of peginterferon therapy in acute hepatitis C: a randomized trial. Hepatology. 2006 May; 43(5):923-31. PMID: 16628640.
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  182. Kamal SM, Turner B, He Q, Rasenack J, Bianchi L, Al Tawil A, Nooman A, Massoud M, Koziel MJ, Afdhal NH. Progression of fibrosis in hepatitis C with and without schistosomiasis: correlation with serum markers of fibrosis. Hepatology. 2006 Apr; 43(4):771-9. PMID: 16557547.
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  183. Wilson LE, Torbenson M, Astemborski J, Faruki H, Spoler C, Rai R, Mehta S, Kirk GD, Nelson K, Afdhal N, Thomas DL. Progression of liver fibrosis among injection drug users with chronic hepatitis C. Hepatology. 2006 Apr; 43(4):788-95. PMID: 16557548.
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  184. Kamal SM, Fouly AE, Kamel RR, Hockenjos B, Al Tawil A, Khalifa KE, He Q, Koziel MJ, El Naggar KM, Rasenack J, Afdhal NH. Peginterferon alfa-2b therapy in acute hepatitis C: impact of onset of therapy on sustained virologic response. Gastroenterology. 2006 Mar; 130(3):632-8. PMID: 16530503.
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  185. Oh S, Afdhal NH. Antiviral therapy for treatment naïve patients with hepatitis C virus. Infect Dis Clin North Am. 2006 Mar; 20(1):99-113, vi-vii. PMID: 16527651.
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  186. Byrnes V, Afdhal N, Challies T, Greenstein PE. Drug induced liver injury secondary to interferon-beta (IFN-beta) in multiple sclerosis. Ann Hepatol. 2006 Jan-Mar; 5(1):56-9. PMID: 16531969.
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  187. Khokar AS, Byrnes V, Afdhal NH . Future therapies for hepatitis C. Current Hepatitis Reports. 2006; 5:121-128.
  188. Wang HH, Afdhal NH, Wang DQ. Overexpression of estrogen receptor alpha increases hepatic cholesterogenesis, leading to biliary hypersecretion in mice. J Lipid Res. 2006 Apr; 47(4):778-86. PMID: 16380638.
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  189. Kelleher TB, Afdhal N. Assessment of liver fibrosis in co-infected patients. J Hepatol. 2006; 44(1 Suppl):S126-31. PMID: 16352364.
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  190. Hari S. Conjeevaram, University of Michigan, Ann Arbor, MI; Michael W. Fried, University of North Carolina, Chapel Hill, NC; Lennox J. Jeffers, VA Medical Center, Miami, FL; Norah Terrault, UCSF, San Francisco, CA; Thelma E. Wiley-Lucas, Rush University Medical Center, Chicago, IL; Nezam Afdhal, Beth Israel Deaconess Medical Center, Boston, MA; Robert S. Brown Jr, New York Presbyterian-Columbia Presbyterian Center, New York, NY; Steve H. Belle, University of Pittsberg, Pittsburgh, PA; Patricia R. Robuck, NIDDK, NIH, Bethesda, MD; Charles D. Howell, University of Maryland, Baltimore, MD. Peginterferon Alfa-2A and ribavirin in African american and caucasian patients with chronic hepatitis C, Genotype 1. hepatology. 2005; 42(4):90A.
  191. Michelle Lai, Benjamin Hyatt, BIDMC, Boston, MA; Nezam Afdhal, BIDMC, Boston, MA. Role of liver Biopsy in Patients with Normal ALT and High HBV DNA. Hepatology. 2005; 42(4):188A.
  192. Ira M. Jacobson, Weill Medical College of Cornell University, new York, NY; Robert S. Brown, Columbia University College of Physicians & Surgeons, New York, NY; Bradley Freilich, Baptist Medical Center, Kansas City, MO; Nezam Afdhal, beth Israel Deaconess Medical Center, Boston, MA; Pauk Kwo, Indian University School of Medicine, Indianapolis, IN; John Santoro, Atlantic Gastroenterology Associates, Egg Harbor Township, NJ; Scott becker, Austin Gastroenterology, PA, Austin, TX; Adil Wakil, California Pacific Medical Center, San Francisco, CA; David Pound, Indianapolis Gastroenterology Rsch, Indianapolis, IN; Eliot Godofsky, Bach and Godofsky, MD PA, Bradenton, FL; Robert Strauss, Northwest Georgia Gastroenterology Associates, P.C. Marietta, GA; David Bernstein, North Shore University Hospital, Mahasset, NY; Steven Flamm, Northwestern Memorial Hospital, Chicago, IL; Natrajan Bala, Gastroenterology consultants, Houston, TX; Victor Araya, Albert Einstein Medical Center, Philadelphia, PA; Mitchell Davis, SOuth Florida center of Gastroenterology, P.A., Wellington, FL; Howard Monsour, Liver Specialists of Texas, Houston, TX; John Vierling, Cedars-Sinai Medical Center, Los Angeles, CA; Fredric Regenstein, Tulane University Medical School, New Orleans, LA; Vijay Balan, Mayo Clinic, Phoenix, AZ; Michael Dragutsky, GI Consultants of the Midshouth, Memphis; TN; Michael Epstein, Digestive Disorders Associates Annapolis, MD; Robert W. Herring, Nashville, TN; Raymond Rubin, Atlanta Gastroenterology Assoc, Atlanta, GA; Greg Galler, Kelsey-Seubold Clinic, Houston, TX; Mary Pat Pauly, Kaiser Permanente, Sacramento, CA; Louis H. Griffel; Clifford A. Brass, Schering-Plough Research Institute, kenilworth, NJ; the WIN-R S. Group, kenilworth, NJ. Weight-based ribavirin dosing (WBD) increases sustained viral response (SVR) in patients with chronic hepatitis C (CHC): Final results of the WIN-R study, A US community based trial. Hepatology. 2005; 42(4):77A.
  193. Yury Popov, BIDMC, Harvard Medical School, Boston, MA; Sebastian Meuller, Brad Turner, BIDMC, Harvard Medical School, Boston, MA; N. Zinkin, BIDMC, Boston, MA; I. Nasser, H. Masuzaki, BIDMC, Harvard Medical School, Boston, MA; J. Vriereck, Dept. or Neurology and Biophysics, Boston Medical Center, Boston, MA; J. Hamilton, Dept. or Neurology and Biophysics Boston Medical Center, Boston, MA; J. Flier, Nezam Afdhal, Detlef Schuppan, BIDMC, Harvard Medical School, Boston, MA. Mice overexpressing 11B-hydroxysteriod-dehydrogenase (HSD-1) in adipose tisure develop NASH and progressive pericentral fibrosis on a high fat diet. Hepatology. 2005; 42(4):168A.
  194. John G. McHutchinson, Duke Univ, Durham, NC; Bruce R. Bacon, St. Louis Univ Hopsital, St. Louis, MO; Stuart C. Gordon, Henry Ford Hospital, Detroit, MI; Eric Lawitz, Alamo Medical Research, San Antonio, TX; Mitchell Shiffman, Medical College of Richmond Virginia, Richmond, VA; Nezam H. Afdhal, Beth Israel Deaconess Medical Center, Boston, MA; Ira M. Jacobson, Cornell Univ, New York, NY; Andrew Muir Duke University, Durham, NC; Susan M. Efler, A. Vicari, K. Myette, Nav Ahluwalia, P.P. Murzenok Coley Pharmalbach, Art M. Krieg, Coley Pharmaceutical Group, Ottawa, Canada. Immunophenotyping profile of CPG 10101, a new TLR9 agonist antiviral for hepatitis C. Hepatology. 2005; 42(4):148A.
  195. Noah T. Zinkin, Beth Israel Deaconess Medical Center, Boston, MA; Hasan H. Otu, Dimitrios Spentzos, Manuel Aivado, Meghan Wells, Beth Israel Deaconess Medical Center, proteomics Core, Boston, MA; Brett D. Kalmowitz, K.R. Bhaskar, Beth Israel Deaconess Medical Center, Boston, MA; Towia A. Libermann, Beth Israel Deaconess Medical Center, Proteomics Core, Boston, MA; Nezam H. Afdhal, Beth Israel Deaconess Medical Center, Boston, MA. A Combined Proteomic and Serologic approach to Diagnosis of Hepatocellular Carcinoma. Hepatology. 2005; vol. 42(no. 4):72A.
  196. John McHutchinson, Duke Univeristy, Durham, NC; Bruce Bacon, St. Louis University Hospital, St. Louis, MO; Stuart C. Gordon, Henry Ford Hospital, Detroit, MI; Eric Lawitz, Alamo Medical Research, San Antonio, TX; Michell Shiffman, Medical College of Virginia, Richmond, VA; Nezam H. Afdhal, Beth Israel Deaconess Medical Center, Boston, MA; Ira Jacobson, Cornell University, New York, NY; Andrew Muir, Duke Univeristy, Duram, NC; Susan Elfer, Coley Pharmaceutical Group, Ottawa, Canada; Mohammed Al-Adhami, Coley Pharmaceuticals Group, Wellesley, MA; Heather Davis, Coley Pharmaceutical Group, Ottawa, Canada; Tess Schmalbach, Coley Pharmaceutical Group, Wellesley, MA. Relationship of HCV RNA responses to CPG 10101, A TLR9 Agonist: Pharmacodynamics and patient characteristics. Hepatology. 2005; 42(4):75A.
  197. Xiao-Jian Zhou, Idenix Pharmaceuticals, Inc., Cambridge, MA; Maribel Rodiguez-Torres, Funacion de Investigacion de Diego, Santurce; Eric Lawitz, Alamo Medical Research, San Antonio, TX; Eliot Godofsky, Bach & Godofsky, Bradenton, FL; Nezam Afdhal, Beth Israel Deaconess Medical Center, Boston, MA; Barbara Fielman Constance, George Chao, Steven Knox, Nathaniel A. Brown, Idenix Pharmaceuticals, Cambridge, MA. Asence of effect of Pegylated interferon Alfa-2B on the pharmacokenetics of valopicitabine (NM283) in patients with chronic hepatitis C. Hepatology. 2005; 42(4):148A.
  198. Christopher O'brien, University of Miami, Miami, FL; Eliot Godofsky, Bach & Godofsky, Brandenton, FL; Maribel Rodriguez-Torres, Fundacion de Investigacion de diego, Sanurce, Puerto Rico; Nezam Afdhal, Beth Israel Deaconess Medical Center, Boston, MA; S.C. Pappas, St. Luke's Episcopal Hospital. Randomized trial of valopicitabine (NM283), alone or with Peg-Interferon, VS. Retreatment with peg-interferon plus ribavirin (Peginf/rbv) in hepatitis C patients with pervious non-response to pegifn/rbv: first interi, results. Hepatology. 2005; vol. 42(no. 4):69A.
  199. Nezam Afdhal, Beth Israel Deaconess Medical Center, Boston, MA; Andres Cardenas, BIDMC, Boston, MA; Monica Guevara Univ Barcelona, Barcelona, Spain; Peter Gross Unvi Car; Gustav Carus Dresden, Dresden, Germany; Joseph varbalis, Georgetown Univ Medical center, Washington, DC; Thomas Berl; Robert Schrier, Univ of Colorado health Science Center, Denver, CO; Daniel Bichet Hospital de sacre Courer de Montreal, Montreal Canada; Lynn Wagoner, Univ of Cinncinnati Heart and Vascular Center. Cincinnati, OH; John Ouyang; Cesare Orlandi; Frank Czerwiec, Otsuka Maryland Research Institute, Rockville, MD. Randomized Placebo-Controlled trial of Tolvaptan, a novel v2-receptor antagonist, in hyponatremia: results of the salt 2 trial with emphasis on efficacy and safety in cirrohosis. hepatology. 2005; 42(4):172A.
  200. John Gross, Stephanie Johnson, Mayo Clinic, Rochester, MN; Paul Kwo, Indiana U. School of Medicine, Indianapolis, IN; Nezam H. Afdhal, beth Israel Deaconess Medical Center, Boston, MA; Stven Flamm, Northwestern U. Department of Medicine, Chicago, IL; Terry Therneau, The RENEW Investigators, Mayo Clinic, Rochester, MN. Double-Dose PegInterferon Alfa-2B with wieghtbased ribavirin improves response for interferon/ribavirin non-responders with hepatitis C: Final results of "RENEW". Hepatology. 2005; vol. 42(No. 4):63A.
  201. Asim Khokhar, Rory farnan, Chelsea MacFarlane, BIDMC, Boston, MA; Bruce Bacon, SLU, St. Louis, MO; John McHutchison, Duke Univ medical center, Durham, NC; Nezam Afdhal, beth Israel Deaconess medical Center, Boston, MA. Liver Stiffness and biomarkers: Correlation with cirrhosis, protal hypertension and hepatic synthetic function. hepatology. 2005; 42(4):112A.
  202. Kelleher TB, Afdhal N. Noninvasive assessment of liver fibrosis. Clin Liver Dis. 2005 Nov; 9(4):667-83, vii. PMID: 16207570.
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  203. Hong Z, Chasan B, Bansil R, Turner BS, Bhaskar KR, Afdhal NH. Atomic force microscopy reveals aggregation of gastric mucin at low pH. Biomacromolecules. 2005 Nov-Dec; 6(6):3458-66. PMID: 16283779.
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  204. Curry MP, Afdhal NH. Use of growth factors with antiviral therapy for chronic hepatitis C. Clin Liver Dis. 2005 Aug; 9(3):439-51, vii. PMID: 16023976.
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  205. Maribel Rodiguez-Torres, Eric Lawitz, Eliot Godofsky, Nezam Afdhal, George Chao, Barbara Fielman Constance, Steven Knox, Nathaniel A. Brown. Valopitabine (nm283) alone and in combination with peg-interferon in patients with genotype 1 chronic hepatitis C: Preliminary results from an ongoing phase II, multicenter study. Gastroenterology. 2005; 128(4):p-90.
  206. Helen H. Wang, Nezam H. Afdhal, David Q. Wang. Impaired Gallbladder motility and accelerated cholesterol crystallization and Gallstone formation in mice overexpressing human mucin gene 1 (hmuc1). Gastroenterology. 2005; 128(4):p-103.
  207. Bruce R. Bacon, John G. McHutchison, Stuart C. Gordon, Nezam H. Afdhal, Ira M. Jacobson, Mitchell Schiffman, Andrew Muir, Arthur M. Krieg, Susan Elfer, Mary Lou Morris, John Whisnant, Mohammed Al-Adhami, Heather Davis, Tess Schmalbach. Safety, Pharmacodynamic (PD) and Pharmacokinetic (PK) profiles of CPG 10101 (Actilon-TM), a novel TLR9 Agonist: Comparison in Normal Volenteers and HCV infected Individuals. Gastroenterology. 2005; 128(4):p-91.
  208. Stephen A. Harrison, Chris Fincke, Sangik Oh, Thomas Kelleher, Katie Smith, Nezam Afdhal. Combined Serological and clinical measures enhance the non-invasive diagnosis of advanced fibrosis in NAFLD. Gastroenterology. 2005; 128(4):p-227.
  209. Sanaa Kamal, Ahmed Al Tawil, Qi HE, Khalifa Sayed, Kheiry El Naggar, Sarah Hakam, Wafaa Saleh, Manal El Sayed, Leonardo Bianchi, Mohamed Madwar, Nezam Afdhal. Long term cohort study of the clinical and histologicalprogression of HCV. Gastroenterology. 2005; 128(4):p-195.
  210. Paul J. Pockros, Lennox Jeffers, Nezam Afdhal, Zachary D. Goodman, David Nelson, Robert Gish, Rajender Reddy, Robert Reindollar, Maribel Rodiguez-Torres, Sima FarisYoung, Sara Sullivan, Lawrence M. Blatt. Final Result of a double-blind, Placebo-controlled trial of the antibibrotic efficacy of INF Gamma-1b in chronic hepatitis C patients with advanced fibrosis or cirrosis. Gastroenterology. 2005; 128(4):p-175.
  211. Xiao-Jian Zhou, Nezam Afdhal, Eliot Godofsky, Jules Dienstag; Vinod Rustgi, Lawton Schick. Lael Duncan, Barbara Fielman Constance, George Chao, Nathaniel A. Brown. Pharmacokinetics and Pharmacodynamics of Valopictabine (nm283), a new nucleoside Hcv polymerase inhibitor: results from a phase I/ii dose-escalation trial in patients with Hcv-1 infection. Gastroenterology. 2005; 128(4):a-700.
  212. Noah T. Zinkin, Hassan H. Otu, Dimitrios Spentzos, Manuel Aivado, meghan Wells, Towia A. Liberman, Nezam H. Afdhal. proteomic Profiling of Hepatocellular carcinoma with Seldi-Tof Mass Spectrometry in Patients with Chronic Liver Disease. Gastroenterology. 2005; 128(4):a-30.
  213. Valerie Byrnes, Anne Miller, Cheryl Weinstein, Erin Hill, Robert Lenkinski, David Alsop, Nezam H. Afdhal. Cerebral Metabolic and neuropsychiatric effects of pegylated interferon (PIFN) therapy in Hepatitis C. Gastroenterology. 2005; 128(4):p-22.
  214. Celli J, Gregor B, Turner B, Afdhal NH, Bansil R, Erramilli S. Viscoelastic properties and dynamics of porcine gastric mucin. Biomacromolecules. 2005 May-Jun; 6(3):1329-33. PMID: 15877349.
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  215. Kelleher TB, Mehta SH, Bhaskar R, Sulkowski M, Astemborski J, Thomas DL, Moore RE, Afdhal NH. Prediction of hepatic fibrosis in HIV/HCV co-infected patients using serum fibrosis markers: the SHASTA index. J Hepatol. 2005 Jul; 43(1):78-84. PMID: 15894397.
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  216. N. Afdhal, M Rodriguez-Torres, E. Lawitz, E. Godofsky, G. Chao, B. Fielman, S Knox, M. Brown, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA; Fundacion de Investigacion de Diego, Santurce, PR, USA; Alamo medical Research, San Antonio, TX, USA; Bach & Godofsky, Bradenton, FL, USA; Idenix Pharmaceuticals, Cambridge, MA, USA. Enhanced Antiviral Efficacy For Valopicitabine (NM283) Plus Peg-Interferon in Hepatitis C Patients With HCV Genotype-1 Infection: Results of a Phase IIa Multicenter Trial. Journal of Hepatology. 2005; 42(2):39-40.
  217. M. Curry, A. Cardenas, N.H. Afdhal. Liver Center, Beth Israel Deaconess Medical Center, Boston, MA, USA. Effect of Maintenance PEG-Intron Therapy on Portal Hypertension and its Complications: Results from the CoPilot Study. Journal of Hepatology. 2005; 42(4):40.
  218. Strickland GT, Tanamly MD, Tadros F, Labeeb S, Makld H, Nessim D, Mikhail N, Magder LS, Afdhal NH, Medhat A, Abdel-Hamid M. Two-year results of a randomised double-blinded trial evaluating silymarin for chronic hepatitis C. Dig Liver Dis. 2005 Jul; 37(7):542-3. PMID: 15975544.
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  219. X.J. Zhou, N. Afdhal, E Godofsky, J. Dienstag, V. Rustgi, L. Schick, D. McInery, B.A. Fielman, N.A. Brown. Idenix Pharmaceuticals, Inc, Cambridge, MA, USA; Beth Israel Deaconess Medical Center, Boston, MA, USA; Bach & Godofsky, Bradenton, FL, USA; Massachusetts general Hospital, Boston, MA, USA; Metropolitan Research, Fairfax, VA, USA; University of Massachusetts Health Center, Worcester, MA, USA; Northwest Medical Specialties, Tacoma, WA, USA. Pharmacokinetics and Pharmacodynamics of Valopicitabine(NM283), A New Nucleoside HCV Polymerase Inhibitor: Results from a phase I/II Dose-Escalation Trial in Patients with HCV-1 Infection. Journal of Hepatology. 2005; 42(4):229.
  220. V.M. Byrnes, H. Shi, S. Kiryu, N.M. Rofsky, N.H. Afdhal. Department of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, MA, USA; Deparment of Radiology, Beth Israel Deaconess medical Center, Boston, MA, USA. The Fate of Arterial Enhancing Nodules on MRI in the Cirrhotic Liver. Journal of Hepatology. 2005; 42(4):90-91.
  221. Cárdenas A, Afdhal NH, Khwaja K. An unusual cause of abdominal pain in a patient with hepatitis C cirrhosis. Gut. 2005 Apr; 54(4):460, 521. PMID: 15753527; PMCID: PMC1774450.
  222. Gish RG, Afdhal NH, Dieterich DT, Reddy KR. Management of hepatitis C virus in special populations: patient and treatment considerations. Clin Gastroenterol Hepatol. 2005 Apr; 3(4):311-8. PMID: 15822034.
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  223. Sulkowski MS, Mehta SH, Torbenson M, Afdhal NH, Mirel L, Moore RD, Thomas DL. Hepatic steatosis and antiretroviral drug use among adults coinfected with HIV and hepatitis C virus. AIDS. 2005 Mar 24; 19(6):585-92. PMID: 15802977.
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  224. Afdhal N. Can serum markers be used to reliably detect liver fibrosis? Nat Clin Pract Gastroenterol Hepatol. 2005 Mar; 2(3):132-3. PMID: 16265151.
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  225. Kelleher TB, Afdhal N. Maintenance therapy for chronic hepatitis C. Curr Gastroenterol Rep. 2005 Feb; 7(1):50-3. PMID: 15701299.
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  226. Pockros PJ, Shiffman ML, Schiff ER, Sulkowski MS, Younossi Z, Dieterich DT, Wright TL, Mody SH, Tang KL, Goon BL, Bowers PJ, Leitz G, Afdhal NH. Epoetin alfa improves quality of life in anemic HCV-infected patients receiving combination therapy. Hepatology. 2004 Dec; 40(6):1450-8. PMID: 15565613.
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  227. Tanamly MD, Tadros F, Labeeb S, Makld H, Shehata M, Mikhail N, Abdel-Hamid M, Shehata M, Abu-Baki L, Medhat A, Magder LS, Afdhal NH, Strickland GT. Randomised double-blinded trial evaluating silymarin for chronic hepatitis C in an Egyptian village: study description and 12-month results. Dig Liver Dis. 2004 Nov; 36(11):752-9. PMID: 15571006.
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  228. Nezham Afdhal, Beth Israel Deaconess Medical Center, Boston, MA; Bradley Freilich, Kansas Digetsive Diseases, Kanas City, MO; Robert Levine, Syracuse Univeristy, Syracuse, NY; Maritin Black, Temple University, Philadelphia, PA; Robert Brown Jr, Columbia College of Physicians and Surgeons, New York, NY; Howard Monsour, GI and Liver Associates, Granbury, TX; Michael O'Brien, Boston Medical Center, Boston, MA; Clifford Brass, Schering Plough, Kenilworth, NJ. Colchicine versus PEG- Intron long term (CoPilot) trial: Interim analysis of clinical outcomes at year 2. Hepatology. 2004; 40(4):239A.
  229. Nezam Afdhal, Beth Israel Deaconess Medical Center, Boston, MA; Eliot Godofsky, Bach & Godofsky, Brandenton, FL; Jules Dienstag, Massachusetts general Hospital, Boston MA; Vinod Rustgi, Metropolitan Research, Fairfax, VA; Lawton Schick, University of Massachusetts Health Center, Worcester, MA; David McEniry, Northwest Medical Specialties, PLLC, Tacoma, WA; Xiao-Jian Zhou, George Chao, Christopher Fang, Barbara Fielman, Maureen Myers, Nathaniel Brown, Idenix Pharmaceuticals, Cambridge, MA. Final phase I/II trial results for NM283, A new polymerase inhibitor for Hepatitis C: Antiviral efficancy and tolerance in patients with HCV-1 infection, including previous interferon failures. Hepatology. 2004; 40(4):726A.
  230. John G McHutchison, Duke University, Durham, NC; Bruce R Bacon, Saint Louis University School of Medicine, Saint Louis MO; Stuart C Gordon, William Beaumont Hospital, Royal Oak, MI; Nezam H Afdhal, Beth Israel Deaconess Medical Center, Boston, MA; Ira M Jacobson, Cornell University, New York, NY; Andrew Muir, Duke Univeristy, Durham, NC; Arthur M Krieg, Susan Efler, Mohammed Al-Adhami, Heather L Davis, Tess K Schmalback, Coley Pharmaceutical Group, Inc. Wellesley, MA. Human pharmacological activity of a new TLR9 agonist antiviral, CPG 10101 (Actilon). Hepatology The official Journal of the American Association for the Study of Liver Disease. 2004; 40(4):697A.
  231. Alex S Befer, Saint Louis University, St Louis, MO; Jorge A Marrero, Univeristy of Michigan, Ann Arbor, MI; Ravi S Chari, Vanderbilt Univeristy, Nashville, TN; Lewis Roberts, Mayo Clinic, Rochester, MN; Nezam Afdhal, Harvard University Beth Israel Deaconess Hopsital, Boston, MA; David van Thiel, Loyola Univeristy, Chicago, IL; Adrian M Di Bisceglie, Saint Louis Univeristy, St Louis, MO. The Epidemiology and survival of patients with Hepatocellular Carcinoma in the United States - A prelininary report from the liver cancer network. Hepatology. 2004; 40(4):216A.
  232. Oh S, Afdhal NH. Antiviral therapy for treatment naïve patients with hepatitis C virus. Gastroenterol Clin North Am. 2004 Sep; 33(3):497-511, viii. PMID: 15324940.
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  233. Afdhal NH. Biopsy or biomarkers: is there a gold standard for diagnosis of liver fibrosis? Clin Chem. 2004 Aug; 50(8):1299-300. PMID: 15277345.
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  234. Durante-Mangoni E, Wang R, Shaulov A, He Q, Nasser I, Afdhal N, Koziel MJ, Exley MA. Hepatic CD1d expression in hepatitis C virus infection and recognition by resident proinflammatory CD1d-reactive T cells. J Immunol. 2004 Aug 01; 173(3):2159-66. PMID: 15265953.
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  235. Wang HH, Afdhal NH, Wang DQ. Estrogen receptor alpha, but not beta, plays a major role in 17beta-estradiol-induced murine cholesterol gallstones. Gastroenterology. 2004 Jul; 127(1):239-49. PMID: 15236189.
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  236. Graham CS, Curry M, He Q, Afdhal N, Nunes D, Fleming C, Horsburgh R, Craven D, Sherman KE, Koziel MJ. Comparison of HCV-specific intrahepatic CD4+ T cells in HIV/HCV versus HCV. Hepatology. 2004 Jul; 40(1):125-32. PMID: 15239095.
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  237. Afdhal NH, Nunes D. Evaluation of liver fibrosis: a concise review. Am J Gastroenterol. 2004 Jun; 99(6):1160-74. PMID: 15180741.
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  238. Afdhal NH, Dieterich DT, Pockros PJ, Schiff ER, Shiffman ML, Sulkowski MS, Wright T, Younossi Z, Goon BL, Tang KL, Bowers PJ. Epoetin alfa maintains ribavirin dose in HCV-infected patients: a prospective, double-blind, randomized controlled study. Gastroenterology. 2004 May; 126(5):1302-11. PMID: 15131791.
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  239. Wang HH, Afdhal NH, Gendler SJ, Wang DQ. Lack of the intestinal Muc1 mucin impairs cholesterol uptake and absorption but not fatty acid uptake in Muc1-/- mice. Am J Physiol Gastrointest Liver Physiol. 2004 Sep; 287(3):G547-54. PMID: 15075252.
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  240. Keyur Patel, David R. Nelson, Nezam Afdhal, Esther Oh, Katie Smith, John G. McHutchison, Don Rockey. Prospective Evaluation of a Serum (FibroSpect II) Panel to Predict Fibrosis in Chronic HCV Patients. Gastroenterology. 2004; 126(4):A-708-9.
  241. Valerie M. Byrnes, Honghu Shi, Shigeru Kiryu, Neil M. Rofsky, Nezam H. Afdhal . The Fate of Arterial Enhancing Nodules on MRI in the Cirrhotic Liver. Gastroenterology. 2004; 126(4):A-679.
  242. Helen H. Wang, Nezam H. Afdhal, David Q.H. Wang. Overexpression of Estrogen Receptor Alfa (ER-Alfa)Inhibits the Negative Feedback Regulation of Cholesterol (Ch) Biosynthesis and Increases Newly Synthesized Ch Leading to Biliary Ch Hypersecretion. Gastroenterology. 2004; 126(4):A-673.
  243. Brett D. Kalmowitz, Lorenzo Rossaro, Howard P. Monsour Jr., Robert S. Brown Jr., Mohamad A. El-Kurdi, K.R. Bhaskar, Nezam H. Afdhal . Des-Gamma Carboxyprothrombin (PIVKA-II)and Alfafetoprotein in Cirrhosis Secondary to HCV. Gastroenterology. 2004; 126(4):A-679.
  244. Wang DQ, Afdhal NH. Genetic analysis of cholesterol gallstone formation: searching for Lith (gallstone) genes. Curr Gastroenterol Rep. 2004 Apr; 6(2):140-50. PMID: 15191694.
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  245. Paul J. Pockros, Mitchell L. Shiffman, Eugene R. Schiff, Nezam H. Afdhal, Mark S. Sulkowski, Zobair Younossi, Teresa Wright, Douglas T. Dieterich, Janice Jenkins, Gerhard J. Leitz, Peter J. Bowers. Long-term Treatment with Epoetin Alfa Maintains Ribavirin Dose and Hemoglobin Levels in Anemic HCV-Infected Patients Receiving Interferon/Ribavirin (IFN/RBV)Therapy. Gastroenterology. 2004; 126(4):A-720.
  246. Eugene R Schiff, Paul Pockros, Mitchell L Shiffman, John McHutchison, Robert Gish, Nezam H Afdhal, Manana Makhviladze, Mira Huyghe, David Hecht, Tilman Oltersdorf, David A. Shapiro. Oral IDN-6556, An Anti-Apoptotic Caspase Inhibitor, Lowers Aminotransferases in HCV Patients. Gastroenterology. 2004; 126(4):A-668.
  247. Eric J. Lawitz, Stephen A. Harrison, Norma S. Cantu, Shailesh C. Kadakia, K.P. Ganeshappa, Frank Adams, Mitchell Davis, Richard Sperling, Naoky Tsai, Andrei Gasic, Tarum Kothari, James Cox, Barry Sanders, Bruce Silverman, Elias Ghandour, Jeffrey Medoff, Vajravel Prasad, Nezam Afdhal, Mark Mailliard, Michael Curry, Alamo Study Group. The Effect of Amantadine on Sustained Virologic Response when Added to Pegylated Interferon Alfa 2b + Weight Based Ribavirin in Previous Nonresponders and Relapsers. Gastroenterology. 2004; 126(4):A-697.
  248. Eliot Godofsky, Nezam Afdhal, Vinod Rustgi, Lawton Shick, Lael Duncan, Xiao-Jian Zhou, George Chao, Christopher Fang, Barbara Fielman, Maureen Myers, Nathaniel Brown. A Phase I/II Dose Escalation Trial Assessing Tolerance, Pharmacokinetics, and Antiviral Activity of NM283, a Novel Antiviral Treatment for Hepatitis C. Gastroenterology. 2004; 126(4):A-681.
  249. Eric J. Lawitz, Norma S. Cantu, Stephen A. Harrison, Shailesh Kadakia, Frank Adams, Mitchell Davis, Richard Sperling, Naoky Tsai, Andrei Gasic, Tarum Kothari, K.P. Ganeshappa, James Cox, Barry Sanders, Bruce Silverman, Elias Ghandour, Jeffrey Medoff, Nezam Afdhal, Mark Mailliard, Michael Curry, Alamo Study Group. The Outcome of Hepatitis C Therapy in African Americans and Hispanics with Persistently Normal Transaminases. Gastroenterology. 2004; 126(4):A-696.
  250. Afdhal NH. Role of epoetin alfa in maintaining ribavirin dose. Gastroenterol Clin North Am. 2004 Mar; 33(1 Suppl):S25-35. PMID: 15081101.
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  251. Afdhal NH, Cao X, Bansil R, Hong Z, Thompson C, Brown B, Wolf D. Interaction of mucin with cholesterol enriched vesicles: role of mucin structural domains. Biomacromolecules. 2004 Mar-Apr; 5(2):269-75. PMID: 15002984.
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  252. Wang HH, Afdhal NH, Gendler SJ, Wang DQ. Targeted disruption of the murine mucin gene 1 decreases susceptibility to cholesterol gallstone formation. J Lipid Res. 2004 Mar; 45(3):438-47. PMID: 14703511.
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  253. Byrnes V, Cárdenas A, Afdhal N, Hanto D. Symptomatic focal nodular hyperplasia during pregnancy: a case report. Ann Hepatol. 2004 Jan-Mar; 3(1):35-7. PMID: 15118579.
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  254. Afdhal NH. The natural history of hepatitis C. Semin Liver Dis. 2004; 24 Suppl 2:3-8. PMID: 15346240.
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  255. Kalmowitz BD, Afdhal NH. Maintenance Therapies for Hepatitis C. Current Hepatitis Reports. 2004; 3:23-9.
  256. Yang C, Zeisberg M, Lively JC, Nyberg P, Afdhal N, Kalluri R. Integrin alpha1beta1 and alpha2beta1 are the key regulators of hepatocarcinoma cell invasion across the fibrotic matrix microenvironment. Cancer Res. 2003 Dec 01; 63(23):8312-7. PMID: 14678990.
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  257. Nezam H Afdhal, Angela Klopfer, Linda Tang, Zobair Younossi. Hemoglobin Increase is Independently Associated with Increased Health-Related Quality of Life (HRQL)in Anemic Interferon/Ribavirin (IFN/RBV)-Treated Hepatitis C Virus (HCV)-Infected Patients Treated with Epoetin Alfa. Hepatology. 2003; 38(4):312A.
  258. Nezam h Afdhal, Betty Goon, Kevin Smith, Zobair Younossi. Epoetin Alfa (EPO) Improves and Maintains Health-Related Quality of Life (HRQL) in Anemic HCV-Infected Patients Receiving Interferon/Ribavirin (IFN/RBV): HRQL Results from the Proactive Study. Hepatology. 2003; 38(4):302-3A.
  259. Nezam H Afdhal, David Q Wang. The Blockade of Estrogen Action by Fulvestrant (ICI 182,780) Prevents Cholesterol Gallstone Formation in the Mouse. Hepatology. 2003; 38(4):195A.
  260. Stuart C Gordon, Bruce R Bacon, Ira M Jacobson, Mitchell L Shiffman, Nezam H Afdhal, Rosie Z Yu, John G McHutchison, Jesse Kwoh. Treatment of Chronic Hepatitis C with ISIS 14803, An Antisense Inhibitor of HCV, Given for 12 Weeks. Hepatology. 2003; 38(4):306-7A.
  261. Hari S Conjeevaram, David E Kleiner, Nezam Afdhal, Robert S Brown, Michael W Fried, Charles D Howell, Lennox J Jeffers, Nora Terrault, Thelma E Wiley, Chris Cherry, Steve Belle, Jay H Hoofnagle. Race, Insulin Resistance, Visceral Adiposity and Hepatic Steatosis in Genotype 1 Patients with Chronic Hepatitis C. Hepatology. 2003; 38(4):347A.
  262. Changqing Yang, Jiyao Wang, Michael Zeisberg, Mary Soubasakos, Nezam H Afdhal, Raghu Kalluri. Epithelial to Mesenchymal Transition During Liver Fibrosis. Hepatology. 2003; 38(4):332A.
  263. Eric J Lawitz, Norma S Cantu, Mitchell Davis, Nezam Afdhal, Michael Curry, Mark Mailliard, Frank Adams, Naoky Tsai, Andrei Gasic, Tarun Kothari, K.P. Ganeshappa, James Cox, Bruce Silverman, Shailesh C Kadakia. Triple Therapy Compared to Standard Pegylated Interferon Alfa 2B + Weight Based Ribavirin for Previous Nonresponders and Relapsers with Chronic Hepatitis C. Hepatology. 2003; 38(4):742A.
  264. John B Gross, Terry M Therneau, Stephanie M Johnson, Paul Y Kwo, Nezam H Afdhal, Steven L Flamm, RENEW Trial Investigators. The RENEW Trial: A National, Multicenter Study of High-Dose Peginterferon Alfa-2B + Ribavirin for Non-Responders with Hepatitis C. Hepatology. 2003; 38(4):312-13A.
  265. Eric J Lawitz, Norma S Cantu, Mitchell Davis, Nezam Afdhal, Michael Curry, Mark Mailliard, Frank AdamsNaoky TsaiTarun Kothari, K.P. Ganeshappa, James Cox, Bruce Silverman, Shailesh C Kadakia. Triple Therapy Compared to Standard Pegylated Interferon Alfa 2B + Weight Based Ribavirin for Treatment Naive Chronic Hepatitis C [Tri-Star Trial]: Final Results. Hepatology. 2003; 38(4):636-7A.
  266. Afdhal NH. Diagnosing fibrosis in hepatitis C: is the pendulum swinging from biopsy to blood tests? Hepatology. 2003 May; 37(5):972-4. PMID: 12717376.
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  267. Nezam H. Afdhal, Douglas T. Dieterich, Paul J. Pockros, Eugene R. Schiff, Mitchell L. Shiffman, Mark S. Sulkowski, Teresa Wright, Zobair Younossi, Peter J. Bowers. Epoetin Alfa Treatment of Anemic HCV-infected Patients Allows for Maintenance of Ribavirin Dose, Increases Hemoglobin Levels, and Improves Quality of Life Vs Placebo: A Randomized, Double-blind, Multi-center Study. Gastroenterology. 2003; 124(4):A-714.
  268. Furqaan Ahmed, Ira M. Jacobson, Robert S. Brown, Jr., Nezam Afdhal, Raymond Rubin, James Spivey, Bradley Freilich, Frederic Regenstein, David Bernstein, Robert Doig, Clifford Brass, WIN-R Study Group. Clinical Significance of Pegylated Interferon Induced Neutropenia: Results from the WIN-R Trial. Gastroenterology. 2003; 124(4):A-700.
  269. Helen H. Wang, Nezam H. Afdhal, David Q.-H. Wang. Targeted Disruption of Mucin Gene 1 (Muc1) Decreases Susceptibility to Cholesterol (Ch) Gallstone Formation in Mice. Gastroenterology. 2003; 124(4):A-698.
  270. Changqing Yang, Hikaru Sugimoto, Sudhakar Akulppalli, Mauricio Giraldo, Nezam Afdhal, Michael Zeisberg, Raghu Kalluri. Effects of BMP-7 on Liver Regeneration after Partial Hepatectomy in Mice. Gastroenterology. 2003; 124(4):A-755.
  271. Afdhal NH. AGA GTP Project 2003, Viral Hepatitis Section. 2003.
  272. Afdhal NH. Hepatic Fibrosis. 2003.
  273. Afdhal NH. Diseases of the Gallbladder and Bile Ducts. Cecils Textbook of Medicine Goldman L, Ed. 2003.
  274. Yang C, Zeisberg M, Mosterman B, Sudhakar A, Yerramalla U, Holthaus K, Xu L, Eng F, Afdhal N, Kalluri R. Liver fibrosis: insights into migration of hepatic stellate cells in response to extracellular matrix and growth factors. Gastroenterology. 2003 Jan; 124(1):147-59. PMID: 12512039.
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  275. S.C. Gordon, B.R. Bacon, I.M. Jacobson, M.L. Shiffman, N.H. Afdhal, J.G. McHutchison, T.J. Kwoh, F.A. Dorr. A Phase II, 12-Week Study of ISIS 14083, An Antisense Inhibitor of HCV for the Treatment of Chronic Hepatitis C. Hepatology. 2002; 36(4):362A.
  276. Changqing Yang, Hikaru Sugimoto, Mauricio Giraldo, Nezam Afdhal, Michael Zeisberg, Raghu Kalluri. Bone Morphogenic Protein-7, a Member of the TGF-Beta Superfamily, Accelerates Liver Regeneration After Partial Hepatectomy in Mice. Hepatology. 2002; 36(4):470A.
  277. Ira Jacobson, Robert S Brown, Jr., Nezam Afdhal, Raymond Rubin, James Spivey, Bradley Freilich, Frederick Regenstein, David Bernstein, Robert Doig, Clifford Brass. Clinical Correlates of HCV Genotype and Viral Load: Findings from the WIN-R Trial. Hepatology. 2002; 36(4):376A.
  278. Changqing Yang, Michael Zeisberg, Nezam Afdhal, Raghu Kalluri. New Insights into the Migratory Behavior of Human Hepatocellular Carcinoma HEPG2 Cells. Hepatology. 2002; 36(4):449A.
  279. Ira Jacobson, Robert S Brown, Jr., Nezam Afdhal, Raymond Rubin, James Spivey, Bradley Freilich, Frederic Regenstein, David Bernstein, Robert Doig, Clifford Brass. Characterictics of HCV Infection in African-Americans: Findings from the WIN-R Trial. Hepatology. 2002; 36(4):377A.
  280. Nezam H. Afdhal, Bradley Freilich, Martin Black, Robert Levine, Clifford Brass. Comparison of Therapy with Peg-Intron 0.5mcg/kg Versus Colchicine 0.6mg BID in 250 Patients with Cirrhosis and HCV; Interim Data from Copilot. Hepatology. 2002; 36(4):312A.
  281. John B. Gross, Paul Kwo, Nezam Afdhal, RENEW Investigator Group. Interim Results in the RENEW Trial: A Dose Comparison Study of High-Dose PegInterferon Alfa-2B and Ribavirin for Interferon/Ribavirin Non-Responders with Chronic Hepatitis C. Hepatology. 2002; 36(4):359A.
  282. Robert Brown, Ira Jacobson, Nezam Afdhal, Ray Rubin, James Spivey, Frederic Regenstein, David Bernstein, Clifford Brass, Bradley Freilich. Racial/Ethnic Differences in Hematologic Toxicity of Pegylated Interferon and Ribavirin Therapy: Analysis of the Win-R Trial. Hepatology. 2002; 36(4):292A.
  283. Nezam H Afdhal, Christopher B O'Brien, Scott C Oshana, Lisa M Dunkle. Potent Anti-HBV Activity of ACH-126,443 Correlated with 14-Day Pharmacokinetics and Safety: Predictions for Activity Against YMDD Mutant Strains. Hepatology. 2002; 36(4):372A.
  284. Helen H Wang, Nezam H Afdhal, David Q Wang. Increased Fecal Neutral Sterol and Bile Acid Excretion Confers Resistance to Diet-Induced Cholesterol (CH) Cholelithiasis in Gallstone-Resistant AKR Mice. Hepatology. 2002; 36(4):460A.
  285. Nezam H. Afdhal, Hiro Masuzaki, Bradley Turner, Imad Nasser, Jeffrey Flier. Transgenic Mice with 11 Beta-Hydroysteroid Dehydrogenase Type 1 Overexpression in Adipocytes Develop Fatty Liver Disease. Hepatology. 2002; 36(4):216A.
  286. Vijayan Balan, Ira M Jacobson, Robert Brown, Jr., Nezam Afdhal, R Rubin, James Spivey, Bradley Freilich, David E Bernstein, Virender Sharma, Clifford Brass, WIN-R Study Group. Regional and Racial Variation of Hepatitis C Genotypes in the United States. Hepatology. 2002; 36(4):711A.
  287. Michael Zeisberg, Kyle Kramer, Changqing Yang, Nazia Akhtar, Nezam Afdhal, Raghu Kalluri. Liver Fibrosis: Extracellular Matrix Microenvironment Regulates Hepatocyte Behavior. Hepatology. 2002; 36(4):489A.
  288. Guo W, Kurze V, Huber T, Afdhal NH, Beyer K, Hamilton JA. A solid-state NMR study of phospholipid-cholesterol interactions: sphingomyelin-cholesterol binary systems. Biophys J. 2002 Sep; 83(3):1465-78. PMID: 12202372; PMCID: PMC1302245.
  289. Byrnes V, Afdhal N. Cholangiocarcinoma of the Hepatic Hilum (Klatskin Tumor). Curr Treat Options Gastroenterol. 2002 Apr; 5(2):87-94. PMID: 11879588.
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  290. Wang DQ, Afdhal NH. Good cholesterol, bad cholesterol: role of oxysterols in biliary tract diseases. Gastroenterology. 2001 Jul; 121(1):216-8. PMID: 11438511.
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  291. Oh S, Afdhal NH. Hepatic fibrosis: are any of the serum markers useful? Curr Gastroenterol Rep. 2001 Feb; 3(1):12-8. PMID: 11177689.
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  292. Bernard Chasan, Zhenning Hong, Rama Bansil, Bradley Turner, K. Ramakrishnan Bhaskar, Nezam Afdhal. Atomic force microscopy of gastric mucin. Bulletin of the American Physical Society March poster presentation at the annual meeting of the American Physical Society, Seattle, WA. 2001; (46(1)):829.
  293. Afdhal NH. Biliary Tract Disease. Primary Care Medicine Noble J, Ed. 2001; 920-7.
  294. Afdhal NH, Geahigan T. Management of the Patient with Chronic Hepatitis. Chronic Viral Hepatitis; Diagnosis and Therapeutics, Wu GY, Koff RS, Eds. 2001; 211-32.
  295. Afdhal NH. Clinical Implications: Hepatitis in the New Millenium. Predictors of response to HCV. 2001.
  296. Zhenning Hong, Rama Bansil, Nezam H. Afdhal, K. Ramakrishnan Bhaskar, Bradley S. Turner. Formation and growth of cholesterol crystals in polymer solutions from model bile. Biophysical Journal (Poster presentation at the 45th annual meeting of the Biophysical Society, Boston, MA Feb. 17-21, 2001). 2001; 2(80):546a.
  297. Afdhal NH. Primary Care Medicine, 3rd Edition. Primary Care Medicine, 3rd Edition Noble J, Ed. 2001; 900-1026.
  298. Curry MP, Afdhal NH. Hepatic adenoma. 2001.
  299. Afdhal NH, Flamm S, Imperial JA, Malet PF, Tong M, Pappas SC, Campagna J. Pegylated (40kDa) Interferon Alfa-2a (PEGASYS) in Combination with Ribavirin , Mycophenolate Mofetil, Amantadine, or Amantadine plus Ribavirin in Patients that did not Respond to Rebetron Therapy: A Preliminary Report of a Randomized , Multicenter Study. Digestive Disease Week Presentation in Atlanta, Ga. 2001.
  300. O'Brien MJ, Keating NM, Elderiny S, Cerda S, Keaveny AP, Afdhal NH, Nunes DP. An assessment of digital image analysis to measure fibrosis in liver biopsy specimens of patients with chronic hepatitis C. Am J Clin Pathol. 2000 Nov; 114(5):712-8. PMID: 11068544.
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  301. N.H. Afdhal. Diseases of the Gallbladder and Biliary Tract. Diseases of the Gallbladder and Biliary Tract N.H. Afdhal, Ed. 2000.
  302. Afdhal NH, Brand M, Apstein A, Cooley J, Hoffman J, Mikolich D, Grace N, O'Connor C, Nunes DP. Randomized controlled trial of interferon A 5mU daily plus ribavirin 1000mg daily versus interferon A 3mU tiw plus ribavirin 1000mg daily in patients with HCV who have never received previous therapy. Hepatology. 2000; (32):363A.
  303. Afdhal NH. Epidemiology and Pathogenesis of Cholesterol Gallstones. Diseases of the Gallbladder and Biliary Tract Afdhal NH, Ed. 2000; 127-46.
  304. Afdhal NH. Options for Non-responders to Combination Therapy. The Non-responding Hepatitis C Patient: Options and Variables, B. Bacon, Ed. 2000; 15-28.
  305. Afdhal NH, Keaveny AP, Nunes DP. Hepatitis C treatment of patients in an urban medical center. Hepatology. 2000; (32):565A.
  306. Afdhal N.H., Curry MP. Non-invasive markers of hepatic fibrosis. 2000.
  307. Keaveny AP, Afdhal NH. A 44 year old woman with sonographic evidence of gallstones. Internal Medicine Heffner JE, Sahn SA, Eds. 2000; 69-71.
  308. Stefan AM, Coulter S, Gray B, LaMorte W, Nikelaeson S, Edge AS, Afdhal NH. Xenogeneic transplantation of porcine hepatocytes into the CCl4 cirrhotic rat model. Cell Transplant. 1999 Nov-Dec; 8(6):649-59. PMID: 10701494.
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  309. Afdhal NH. Crohn's and stones. Am J Gastroenterol. 1999 May; 94(5):1130-2. PMID: 10235182.
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  310. Nunes DP, Afdhal NH, Offner GD. A recombinant bovine gallbladder mucin polypeptide binds biliary lipids and accelerates cholesterol crystal appearance time. Gastroenterology. 1999 Apr; 116(4):936-42. PMID: 10092316.
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  311. Cao X, Bansil R, Bhaskar KR, Turner BS, LaMont JT, Niu N, Afdhal NH. pH-dependent conformational change of gastric mucin leads to sol-gel transition. Biophys J. 1999 Mar; 76(3):1250-8. PMID: 10049309; PMCID: PMC1300105.
  312. Raj V., Afdhal N.H. Cholangitis in the immunosuppressed patient (AIDS Cholangiopathy). 1999.
  313. Afdhal N.H. Protecting New Jersey's Public Health; What healthcare professionals must know about hepatitis C. 1999.
  314. Lowe R., Afdhal N.H. Cystic diseases of biliary tract. 1999.
  315. Afdhal NH. Bacterial, Fungal and Granulomatous Diseases of the Liver. Therapy of Digestive Disorders Wolfe MM, Ed. 1999; 315-22.
  316. Nunes DP, Anastopolous H, Gordon F, Chopra S, Petruff C, Salomons H, Wilson S, Afdhal NH. Double blind placebo controlled study of interferon versus interferon plus ribavirin for the treatment of hepatitis C in patients who previously failed interferon monotherapy. Hepatology. 1999; (30):199A.
  317. Afdhal N.H. Approach to the patient with incidental gallstones. 1999.
  318. Keaveny A, Cardenas A, Nunes DP, Edge AE, Afdhal NH. Peripheral TH1 and TH2 cytokine responses in patients with HCV treated with interferon and interferon-ribavirin. Hepatology. 1999; (30):356A.
  319. Offner GD, Nunes DP, Keates AC, Afdhal NH, Troxler RF. The amino-terminal sequence of MUC5B contains conserved multifunctional D domains: implications for tissue-specific mucin functions. Biochem Biophys Res Commun. 1998 Oct 09; 251(1):350-5. PMID: 9790959.
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  320. Wong DK, Dudley DD, Afdhal NH, Dienstag J, Rice CM, Wang L, Houghton M, Walker BD, Koziel MJ. Liver-derived CTL in hepatitis C virus infection: breadth and specificity of responses in a cohort of persons with chronic infection. J Immunol. 1998 Feb 01; 160(3):1479-88. PMID: 9570570.
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  321. Zakko S., Afdhal N.H. Treatment of acute cholecystitis. 1998.
  322. Lowe R., Afdhal N.H. Cholangiocarcinoma. 1998.
  323. Zakko S., Afdhal N.H. Clinical features and diagnosis of acute cholecystitis. 1998.
  324. Keavney AP, Offner GD, Afdhal NH. Inducible nitric oxide is the principal isoform expressed in human gallbladder. Gastroenterology. 1998; (114):526A.
  325. Nunes DP, Keaveny A, Gunsalus R, Lebel MD, Edge ASB, Offner GD, Afdhal NH. Serum cytokine profiles in patients with chronic HCV: Effect of interferon treatment. Hepatology. 1998; (28):364A.
  326. Tung BY, Afdhal NH, Nunes DP, Thummel KE, Kharasch ED, Croghan AM, Cox PP, Lin M, Kowdley KV. The effect of iron depletion on serum markers of lipid peroxidation and fibrosis in hepatitis C. Hepatology. 1998; (28):568A.
  327. Eder MI, Nunes DP, Afdhal NH, Offner GD. TNF-a stimulates mucin secretion, but not mucin synthesis in human gallbladder epithelial cells. Gastroenterology. 1998; (114):1238A.
  328. Nunes DP, Offner GD, Afdhal NH. Reduced sensitivity of HCV genotype 3 to interferon when co-infected with genotype 1. Gastroenterology. 1998; (114):1314A.
  329. Lucas W., Afdhal N.H. Epidemiology of and risk factors for gallstones. 1998.
  330. Nunes DP, Thim L, Niu N, Afdhal NH, Offner GD. Human spasmolytic polypeptide (hSP) significantly enhances the cholesterol crystal nucleating properties of mucin. Gastroenterology. 1998; (114):1313A.
  331. Afdhal N.H. HCV and HIV Co-infection. 1998.
  332. Afdhal N.H. Acalculous cholecystitis. 1998.
  333. Afdhal N.H. Clinicians Companion I&II: Management of Hepatitis C. 1998.
  334. Afdhal NH, Keaveny AP, Cohen SB, Nunes DP, Maldonado N, O'Brien M, Stone PJ. Urinary assays for desmosine and hydroxylysylpyridinoline in the detection of cirrhosis. J Hepatol. 1997 Dec; 27(6):993-1002. PMID: 9453424.
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  335. Cao X, Bansil R, Gantz D, Moore EW, Niu N, Afdhal NH. Diffusion behavior of lipid vesicles in entangled polymer solutions. Biophys J. 1997 Oct; 73(4):1932-9. PMID: 9336189; PMCID: PMC1181094.
  336. Keates AC, Nunes DP, Afdhal NH, Troxler RF, Offner GD. Molecular cloning of a major human gall bladder mucin: complete C-terminal sequence and genomic organization of MUC5B. Biochem J. 1997 May 15; 324 ( Pt 1):295-303. PMID: 9164870; PMCID: PMC1218430.
  337. Salomons H, Keaveny AP, Henihan R, Offner G, Sengupta A, Lamorte WW, Afdhal NH. Nitric oxide and gallbladder motility in prairie dogs. Am J Physiol. 1997 Apr; 272(4 Pt 1):G770-8. PMID: 9142907.
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  338. Raj V, Afdhal N.H. Acute Cholangitis, Up to Date in Medicine, Gastroenterology Series. 1997.
  339. Keaveny A, Karasik M, Afdhal NH. Pancreatic and Hepatobiliary Infections in AIDS Patients. Gastrointestinal Infections LaMont JT, Ed. 1997; 361-97.
  340. Keavney A., Afdhal N.H. Gallstone Ileus. 1997.
  341. Afdhal N.H. Complications of laparoscopic cholecystectomy. 1997.
  342. Afdhal N.H. Abnormal liver function tests for the Primary Care Physician, Core Curriculum in Medicine. 1997.
  343. Afdhal N.H. Colorectal Cancer Screening, Core Curriculum in Medicine. 1997.
  344. Cao X, Niu N, Offner GD, Nunes D, Bansil R, Wolf DE, Afdhal NH. Mucin vesicle interactions are biphasic and depend on mucin glycosylated and non-glycosylated structural domains. Gastroenterology. 1997; (112):1237A.
  345. Lowe R, Bodkin S, Kenney T, Afdhal NH. Substance P is not a neuromediator of splanchnic hyperemia or portal hypertension in the cirrhotic rat. Gastroenterology. 1997; (112):1324A.
  346. Karasik M, Afdhal NH. Small Bowel and Colonic Infections in AIDS Patients. Gastrointestinal Infections LaMont JT, Ed. 1997; 191-247.
  347. Moore EW, Darby GH, Rege RV, Afdhal NH. What prevents digestion of the gallbladder? Phospholipid protects against the toxic effect of taurochenodeoxycholate but not taurocholate. Gastroenterology. 1997; (112):1337A.
  348. Mac Mathuna P, Siegenberg D, Gibbons D, Gorin D, O'Brien M, Afdhal NA, Chuttani R. The acute and long-term effect of balloon sphincteroplasty on papillary structure in pigs. Gastrointest Endosc. 1996 Dec; 44(6):650-5. PMID: 8979052.
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  349. Schroy PC, Wilson S, Afdhal N. Feasibility of high-volume screening sigmoidoscopy using a flexible fiberoptic endoscope and a disposable sheath system. Am J Gastroenterol. 1996 Jul; 91(7):1331-7. PMID: 8677989.
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  350. Zijlstra AI, Offner GD, Afdhal NH, van Overveld M, Tytgat GN, Groen AK. The pronase resistance of cholesterol-nucleating glycoproteins in human bile. Gastroenterology. 1996 Jun; 110(6):1926-35. PMID: 8964420.
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  351. Moore EW, Darby G, Afdhal NH. What prevents the gallbladder from digesting itself? Studies of taurochenodeoxycholate toxicity. Gastroenterology. 1996; (110):1268A.
  352. Afdhal NH, Nunes D. Acalculous cholecystitis. Consultations in Gastroenterology Snape WJ, Ed. 1996; 853-7.
  353. Nunes D, Sharma A, Cohen S, Rea C, Offner GD, Apstein M, Afdhal NH. Randomized trial of interferon dose escalation for the treatment of chronic hepatitis C. Gastroenterology. 1996; (110):1281A.
  354. Karasik M, Afdhal NH. Biliary Tract Disease. Primary Care Medicine Noble J, Ed. 1996; 605-13.
  355. Offner GD, Nunes DP, Zhang F, McAnany DB, Afdhal NH. Alterations in gallbladder mucin gene expression in patients with cholesterol gallstones. Gastroenterology. 1996; (110):1282A54.
  356. Karasik M, Afdhal NH. Gastrointestinal Manifestations of AIDS. HIV Infection: A Clinical Manual Libman H, Witzburg RA, Eds. 1996; 165-80.
  357. Koziel MJ, Dudley D, Afdhal N, Grakoui A, Rice CM, Choo QL, Houghton M, Walker BD. HLA class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus. Identification of multiple epitopes and characterization of patterns of cytokine release. J Clin Invest. 1995 Nov; 96(5):2311-21. PMID: 7593618; PMCID: PMC185882.
  358. Afdhal NH, Ostrow JD, Koehler R, Niu N, Groen AK, Veis A, Nunes DP, Offner GD. Interaction of bovine gallbladder mucin and calcium-binding protein: effects on calcium phosphate precipitation. Gastroenterology. 1995 Nov; 109(5):1661-72. PMID: 7557151.
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  359. Afdhal NH, Niu N, Nunes DP, Bansil R, Cao XX, Gantz D, Small DM, Offner GD. Mucin-vesicle interactions in model bile: evidence for vesicle aggregation and fusion before cholesterol crystal formation. Hepatology. 1995 Sep; 22(3):856-65. PMID: 7657293.
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  360. Nunes DP, Keates AC, Afdhal NH, Offner GD. Bovine gall-bladder mucin contains two distinct tandem repeating sequences: evidence for scavenger receptor cysteine-rich repeats. Biochem J. 1995 Aug 15; 310 ( Pt 1):41-8. PMID: 7646470; PMCID: PMC1135851.
  361. Offner GD, Nunes DP, Moore EW, Afdhal NH. Prostaglandin E1 stimulates mucin secretion and increases MUC3 mRNA levels in cultured human gallbladder epithelial cells. Hepatology. 1995; (22):110.
  362. Duzendorfer D, Lee V, Chipkin S, Afdhal NH, Karasik M. HIDA scintigraphy as a test for small intestinal transit: Effect of acute hyperglycemia. American Journal of Gastroenterology. 1995; (90):1631.
  363. Afdhal NH, Carey MC. New Perspectives on Gallstone Pathogenesis and Prevention. Journal of the Irish Colleges of Physicians and Surgeons. 1995; 24:267-78.
  364. Kenney TJ, Stefan A, Nunes DP, Offner GD, Nikulasson S, Pouthalakis C and Afdhal NH. Effect of substance P and its receptor antagonist CP-96,345 on systemic arterial and portal pressure in normal and cirrhotic rats. Hepatology. 1995; (22):258.
  365. Karasik M, Dunzendorfer T, Lee V, Chipkin S, Afdhal NH. Acute hyperglycemia impairs gallbladder motility in normal but not diabetic men. American Journal of Gastroenterology. 1995; (90):1606.
  366. Offner GD, Gong D, Afdhal NH. Identification of a 130-kilodalton human biliary concanavalin A binding protein as aminopeptidase N. Gastroenterology. 1994 Mar; 106(3):755-62. PMID: 7907074.
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  367. Afdhal NH, LaMont JT. Pathogenesis of Gallstones. Principles and Practices of Gastroenterology and Hepatology, Gitnick G, Ed. 1994; 561-571.
  368. LaMont JT, Afdhal NH. Cholesterol Gallstone Disease: From Pathogenesis to Prevention. Current Opinion in Gastroenterology. 1994; 10:523-5.
  369. Purdum PP, Afdhal NH, Rege R, Moore EW. Effect of mucus gel layer on phospholipid transfer across human cultured gallbladder epithelia. Hepatology. 1994; (20):115.
  370. Lataif LE, Niu N, Offner GD, Afdhal NH. Interaction of biliary cholesterol with mucin gels. Gastroenterology. 1994; (106):925A.
  371. Koziel MJ, Dudley D, Afdhal N, Choo QL, Houghton M, Ralston R, Walker BD. Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV. J Virol. 1993 Dec; 67(12):7522-32. PMID: 7693974; PMCID: PMC238218.
  372. Kline TJ, De las Morenas T, O'Brien M, Smith BF, Afdhal NH. Squamous metaplasia of extrahepatic biliary system in an AIDS patient with cryptosporidia and cholangitis. Dig Dis Sci. 1993 May; 38(5):960-2. PMID: 8482197.
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  373. Afdhal NH, Niu N, Gantz D, Small DM, Smith BF. Bovine gallbladder mucin accelerates cholesterol monohydrate crystal growth in model bile. Gastroenterology. 1993 May; 104(5):1515-23. PMID: 8482463.
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  374. Afdhal NH, Gong D, Niu N, Turner B, LaMont JT, Offner GD. Cholesterol cholelithiasis in the prairie dog: role of mucin and nonmucin glycoproteins. Hepatology. 1993 Apr; 17(4):693-700. PMID: 8477974.
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  375. Karasik MS, Dunzendorfer T, Lee V, Chipkin S, Afdhal NH. Acute hyperglycemia impairs gallbladder and small intestinal motility in normal men. Gastroenterology. 1993; (104):530.
  376. Afdhal NH. Gastrointestinal manifestations of the Acquired Immunodeficiency Syndrome. HIV Infection: A Clinical Manual Libman H, Witzburg R, Eds. 1993; 146-159.
  377. Afdhal NH, Niu N, Nunes D, Bansil R, Gantz D, Small DM, Offner GD. Molecular basis of nucleation: differences between slow and fast pro-nucleating proteins. Gastroenterology. 1993; (104):867.
  378. O'Brien S, Keogan M, Patchett S, McCormick PA, Afdhal N, Hegarty JE. Postprandial changes in portal haemodynamics in patients with cirrhosis. Gut. 1992 Mar; 33(3):364-7. PMID: 1568656; PMCID: PMC1373829.
  379. Afdhal NH, Long A, Lennon J, Crowe J, O'Donoghue DP. Controlled trial of antimycobacterial therapy in Crohn's disease. Clofazimine versus placebo. Dig Dis Sci. 1991 Apr; 36(4):449-53. PMID: 2007362.
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  380. Niu N, Smith BF, Small DM, Afdhal NH. Calcium preferentially accelerates gallbladder mucin induced cholesterol monohydrate crystal nucleation rather than crystal growth in model bile. Gastroenterology. 1991; (100):781.
  381. Afdhal NH, Offner GD, Smith BF. Characterization of bovine gallbladder mucin. Amino acid sequences of tryptic peptides from the glycosylated domain of the protein core. Gastroenterology. 1990 Nov; 99(5):1493-501. PMID: 2210258.
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  382. Afdhal NH, Offner GD, Murray FE, Troxler RF, Smith BF. Isolation and characterization of peptides from the protein core of bovine gallbladder mucin. Gastroenterology. 1990 Jun; 98(6):1633-41. PMID: 2186955.
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  383. Afdhal NH, Smith BF. Cholesterol crystal nucleation: a decade-long search for the missing link in gallstone pathogenesis. Hepatology. 1990 Apr; 11(4):699-702. PMID: 2184117.
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  384. Afdhal NH, Smith BF. Pathogenesis of Cholesterol Gallstones. Viewpoints on Digestive Disease. 1990; 22:13-18.
  385. Gourdin TG, Afdhal NH, Niu N, Smith BF. Calcium augments binding of bilirubin to bovine gallbladder mucin. Hepatology. 1990; 12:899.
  386. Patchett SE, Enright H, Afdhal N, O'Connell W, O'Donoghue DP. Clot lysis by gastric juice: an in vitro study. Gut. 1989 Dec; 30(12):1704-7. PMID: 2612985; PMCID: PMC1434462.
  387. Afdhal NH, Kelly J, McCormick PA, O'Donoghue DP. Remission induction in refractory Crohns disease using a high calorie whole diet. JPEN J Parenter Enteral Nutr. 1989 Jul-Aug; 13(4):362-5. PMID: 2778940.
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  388. Keane TE, Dillon B, Afdhal NH, McCormack CJ. Conservative management of perforated duodenal ulcer. Br J Surg. 1988 Jun; 75(6):583-4. PMID: 3395828.
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  389. McCormick PA, Ramsay N, Afdhal N, Shattuck AG, Hillary IB, Tubridy D, O'Donoghue DP. Serological markers of hepatitis B virus (HBV) infection in alcoholics and hospital controls. Ir J Med Sci. 1988 Mar; 157(3):77-8. PMID: 3391755.
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  390. Bulger K, Afdhal NH, O'Donoghue DP. A Colorectal Cancer Database. Computers in Gastroenterology Vickery R, Editor. 1988.
  391. Afdhal NH, Long A, Tobbia I, Cullen A, O'Donoghue DP. Immunohistochemical Cal9-9 in primary colonic polyps and polyps synchronous with colorectal cancer. Gut. 1987 May; 28(5):594-600. PMID: 3297939; PMCID: PMC1432871.
  392. Afdhal NH, Piggott C, Long AA, O'Donoghue DP. Carbohydrate handling by colonic flora--is it pathogenic in the irritable bowel syndrome? Ir J Med Sci. 1986 Jun; 155(6):197-201. PMID: 3733401.
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  393. Duffy MJ, O'Sullivan F, O'Donoghue D, Afdhal NH, Kelleher D. Ca-19-9, a new marker for gastrointestinal malignancy. Ir J Med Sci. 1985 Oct; 154(10):385-6. PMID: 3865919.
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  394. Afdhal NH, Chman M, Doyle D, Horgan JH. Obstructive sleep apnoea syndrome presenting as cardiac arrhythmia. Ir J Med Sci. 1985 Mar; 154(3):120-3. PMID: 3997447.
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  395. Afdhal NH, Smith J, Heffernan S, Doyle JS, Gaffney E. Acute small bowel obstruction secondary to endometriosis: two case reports and a review of the literature. Ir Med J. 1984 May; 77(5):141-3. PMID: 6735681.
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  396. Keatinge AM, Johnson AH, Collins PB, Afdhal N, Lynch D, Lavin JN. Vitamin B1, B2, B6 and C status in the elderly. Ir Med J. 1983 Dec; 76(12):488-90. PMID: 6668172.
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