Harvard Catalyst Profiles

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Michael J. Coyne, B.S.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Tomek MB, Janesch B, Braun ML, Taschner M, Figl R, Grünwald-Gruber C, Coyne MJ, Blaukopf M, Altmann F, Kosma P, Kählig H, Comstock LE, Schäffer C. A Combination of Structural, Genetic, Phenotypic and Enzymatic Analyses Reveals the Importance of a Predicted Fucosyltransferase to Protein O-Glycosylation in the Bacteroidetes. Biomolecules. 2021 11 30; 11(12). PMID: 34944439.
    Citations:    Fields:    Translation:Cells
  2. Bozorgmanesh R, Thornton J, Snyder J, Fletcher C, Mack R, Coyne M, Murphy R, Hegarty E, Slovis N. Symmetric dimethylarginine concentrations in healthy neonatal foals and mares. J Vet Intern Med. 2021 Nov; 35(6):2891-2896. PMID: 34738665.
    Citations: 1     Fields:    Translation:Animals
  3. Matano LM, Coyne MJ, García-Bayona L, Comstock LE. Bacteroidetocins Target the Essential Outer Membrane Protein BamA of Bacteroidales Symbionts and Pathogens. mBio. 2021 10 26; 12(5):e0228521. PMID: 34517753.
    Citations:    Fields:    Translation:HumansAnimalsCells
  4. García-Bayona L, Coyne MJ, Comstock LE. Mobile Type VI secretion system loci of the gut Bacteroidales display extensive intra-ecosystem transfer, multi-species spread and geographical clustering. PLoS Genet. 2021 04; 17(4):e1009541. PMID: 33901198.
    Citations: 4     Fields:    Translation:HumansCells
  5. Ben-Assa N, Coyne MJ, Fomenkov A, Livny J, Robins WP, Muniesa M, Carey V, Carasso S, Gefen T, Jofre J, Roberts RJ, Comstock LE, Geva-Zatorsky N. Analysis of a phase-variable restriction modification system of the human gut symbiont Bacteroides fragilis. Nucleic Acids Res. 2020 11 04; 48(19):11040-11053. PMID: 33045731.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  6. García-Bayona L, Coyne MJ, Hantman N, Montero-Llopis P, Von SS, Ito T, Malamy MH, Basler M, Barquera B, Comstock LE. Nanaerobic growth enables direct visualization of dynamic cellular processes in human gut symbionts. Proc Natl Acad Sci U S A. 2020 09 29; 117(39):24484-24493. PMID: 32938803.
    Citations: 2     Fields:    Translation:HumansCells
  7. Ito T, Gallegos R, Matano LM, Butler NL, Hantman N, Kaili M, Coyne MJ, Comstock LE, Malamy MH, Barquera B. Genetic and Biochemical Analysis of Anaerobic Respiration in Bacteroides fragilis and Its Importance In Vivo. mBio. 2020 02 04; 11(1). PMID: 32019804.
    Citations: 7     Fields:    Translation:AnimalsCells
  8. Szlosek D, Robertson J, Quimby J, Mack R, Ogeer J, Clements C, McCrann DJ, Coyne MJ. A retrospective evaluation of the relationship between symmetric dimethylarginine, creatinine and body weight in hyperthyroid cats. PLoS One. 2020; 15(1):e0227964. PMID: 31990929.
    Citations: 3     Fields:    Translation:Animals
  9. Le Sueur ANV, Geraldes SS, Melchert A, Takahira RK, Coyne M, Murphy R, Szlosek D, Guimarães-Okamoto PTC. Symmetric dimethylarginine concentrations in dogs with International Renal Interest Society stage 4 chronic kidney disease undergoing intermittent hemodialysis. J Vet Intern Med. 2019 Nov; 33(6):2635-2643. PMID: 31513317.
    Citations: 2     Fields:    Translation:Animals
  10. Coyne MJ, Béchon N, Matano LM, McEneany VL, Chatzidaki-Livanis M, Comstock LE. A family of anti-Bacteroidales peptide toxins wide-spread in the human gut microbiota. Nat Commun. 2019 08 01; 10(1):3460. PMID: 31371723.
    Citations: 17     Fields:    Translation:HumansCells
  11. Shumaker AM, Laclare McEneany V, Coyne MJ, Silver PA, Comstock LE. Identification of a Fifth Antibacterial Toxin Produced by a Single Bacteroides fragilis Strain. J Bacteriol. 2019 04 15; 201(8). PMID: 30692177.
    Citations: 7     Fields:    Translation:Cells
  12. Coyne MJ, Comstock LE. Type VI Secretion Systems and the Gut Microbiota. Microbiol Spectr. 2019 03; 7(2). PMID: 30825301.
    Citations: 28     Fields:    Translation:HumansCells
  13. Ernst R, Ogeer J, McCrann D, Cross J, Strong-Townsend M, Friis H, Coyne M, Clements C, Drake C, Murphy R. Comparative performance of IDEXX SDMA Test and the DLD SDMA ELISA for the measurement of SDMA in canine and feline serum. PLoS One. 2018; 13(10):e0205030. PMID: 30321185.
    Citations: 9     Fields:    Translation:Animals
  14. McEneany VL, Coyne MJ, Chatzidaki-Livanis M, Comstock LE. Acquisition of MACPF domain-encoding genes is the main contributor to LPS glycan diversity in gut Bacteroides species. ISME J. 2018 12; 12(12):2919-2928. PMID: 30065309.
    Citations: 10     Fields:    Translation:HumansCells
  15. Chatzidaki-Livanis M, Coyne MJ, Roelofs KG, Gentyala RR, Caldwell JM, Comstock LE. Gut Symbiont Bacteroides fragilis Secretes a Eukaryotic-Like Ubiquitin Protein That Mediates Intraspecies Antagonism. mBio. 2017 11 28; 8(6). PMID: 29184019.
    Citations: 15     Fields:    Translation:HumansCells
  16. Roelofs KG, Coyne MJ, Gentyala RR, Chatzidaki-Livanis M, Comstock LE. Bacteroidales Secreted Antimicrobial Proteins Target Surface Molecules Necessary for Gut Colonization and Mediate Competition In Vivo. mBio. 2016 08 23; 7(4). PMID: 27555309.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  17. Coyne MJ, Comstock LE. A New Pillar in Pilus Assembly. Cell. 2016 Apr 21; 165(3):520-1. PMID: 27104974.
    Citations: 1     Fields:    Translation:HumansCells
  18. Coyne MJ, Roelofs KG, Comstock LE. Type VI secretion systems of human gut Bacteroidales segregate into three genetic architectures, two of which are contained on mobile genetic elements. BMC Genomics. 2016 Jan 15; 17:58. PMID: 26768901.
    Citations: 64     Fields:    Translation:HumansCells
  19. Chatzidaki-Livanis M, Coyne MJ, Comstock LE. An antimicrobial protein of the gut symbiont Bacteroides fragilis with a MACPF domain of host immune proteins. Mol Microbiol. 2014 Dec; 94(6):1361-74. PMID: 25339613.
    Citations: 32     Fields:    Translation:HumansCells
  20. Coyne MJ, Zitomersky NL, McGuire AM, Earl AM, Comstock LE. Evidence of extensive DNA transfer between bacteroidales species within the human gut. mBio. 2014 Jun 17; 5(3):e01305-14. PMID: 24939888.
    Citations: 56     Fields:    Translation:HumansCells
  21. Rakoff-Nahoum S, Coyne MJ, Comstock LE. An ecological network of polysaccharide utilization among human intestinal symbionts. Curr Biol. 2014 Jan 06; 24(1):40-49. PMID: 24332541.
    Citations: 129     Fields:    Translation:HumansCells
  22. Coyne MJ, Fletcher CM, Chatzidaki-Livanis M, Posch G, Schaffer C, Comstock LE. Phylum-wide general protein O-glycosylation system of the Bacteroidetes. Mol Microbiol. 2013 May; 88(4):772-83. PMID: 23551589.
    Citations: 31     Fields:    Translation:Cells
  23. Posch G, Pabst M, Neumann L, Coyne MJ, Altmann F, Messner P, Comstock LE, Schäffer C. "Cross-glycosylation" of proteins in Bacteroidales species. Glycobiology. 2013 May; 23(5):568-77. PMID: 23258847.
    Citations: 14     Fields:    Translation:Cells
  24. Coyne MJ, Fletcher CM, Reinap B, Comstock LE. UDP-glucuronic acid decarboxylases of Bacteroides fragilis and their prevalence in bacteria. J Bacteriol. 2011 Oct; 193(19):5252-9. PMID: 21804000.
    Citations: 5     Fields:    Translation:Cells
  25. Zitomersky NL, Coyne MJ, Comstock LE. Longitudinal analysis of the prevalence, maintenance, and IgA response to species of the order Bacteroidales in the human gut. Infect Immun. 2011 May; 79(5):2012-20. PMID: 21402766.
    Citations: 60     Fields:    Translation:HumansCells
  26. Fletcher CM, Coyne MJ, Comstock LE. Theoretical and experimental characterization of the scope of protein O-glycosylation in Bacteroides fragilis. J Biol Chem. 2011 Feb 04; 286(5):3219-26. PMID: 21115495.
    Citations: 28     Fields:    Translation:Cells
  27. Chatzidaki-Livanis M, Coyne MJ, Comstock LE. A family of transcriptional antitermination factors necessary for synthesis of the capsular polysaccharides of Bacteroides fragilis. J Bacteriol. 2009 Dec; 191(23):7288-95. PMID: 19801412.
    Citations: 26     Fields:    Translation:Cells
  28. Fletcher CM, Coyne MJ, Villa OF, Chatzidaki-Livanis M, Comstock LE. A general O-glycosylation system important to the physiology of a major human intestinal symbiont. Cell. 2009 Apr 17; 137(2):321-31. PMID: 19379697.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  29. Coyne MJ, Chatzidaki-Livanis M, Paoletti LC, Comstock LE. Role of glycan synthesis in colonization of the mammalian gut by the bacterial symbiont Bacteroides fragilis. Proc Natl Acad Sci U S A. 2008 Sep 02; 105(35):13099-104. PMID: 18723678.
    Citations: 48     Fields:    Translation:AnimalsCells
  30. Chatzidaki-Livanis M, Coyne MJ, Roche-Hakansson H, Comstock LE. Expression of a uniquely regulated extracellular polysaccharide confers a large-capsule phenotype to Bacteroides fragilis. J Bacteriol. 2008 Feb; 190(3):1020-6. PMID: 18039760.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  31. Coyne MJ, Comstock LE. Niche-specific features of the intestinal bacteroidales. J Bacteriol. 2008 Jan; 190(2):736-42. PMID: 17993536.
    Citations: 39     Fields:    Translation:HumansCells
  32. Fletcher CM, Coyne MJ, Bentley DL, Villa OF, Comstock LE. Phase-variable expression of a family of glycoproteins imparts a dynamic surface to a symbiont in its human intestinal ecosystem. Proc Natl Acad Sci U S A. 2007 Feb 13; 104(7):2413-8. PMID: 17284602.
    Citations: 31     Fields:    Translation:HumansCells
  33. Roche-Hakansson H, Chatzidaki-Livanis M, Coyne MJ, Comstock LE. Bacteroides fragilis synthesizes a DNA invertase affecting both a local and a distant region. J Bacteriol. 2007 Mar; 189(5):2119-24. PMID: 17189372.
    Citations: 10     Fields:    Translation:Cells
  34. Coyne MJ, Reinap B, Lee MM, Comstock LE. Human symbionts use a host-like pathway for surface fucosylation. Science. 2005 Mar 18; 307(5716):1778-81. PMID: 15774760.
    Citations: 125     Fields:    Translation:HumansAnimalsCells
  35. Weinacht KG, Roche H, Krinos CM, Coyne MJ, Parkhill J, Comstock LE. Tyrosine site-specific recombinases mediate DNA inversions affecting the expression of outer surface proteins of Bacteroides fragilis. Mol Microbiol. 2004 Sep; 53(5):1319-30. PMID: 15387812.
    Citations: 20     Fields:    Translation:AnimalsCells
  36. Comstock LE, Coyne MJ. Bacteroides thetaiotaomicron: a dynamic, niche-adapted human symbiont. Bioessays. 2003 Oct; 25(10):926-9. PMID: 14505359.
    Citations: 35     Fields:    Translation:HumansCells
  37. Coyne MJ, Weinacht KG, Krinos CM, Comstock LE. Mpi recombinase globally modulates the surface architecture of a human commensal bacterium. Proc Natl Acad Sci U S A. 2003 Sep 02; 100(18):10446-51. PMID: 12915735.
    Citations: 50     Fields:    Translation:HumansCells
  38. Krinos CM, Coyne MJ, Weinacht KG, Tzianabos AO, Kasper DL, Comstock LE. Extensive surface diversity of a commensal microorganism by multiple DNA inversions. Nature. 2001 Nov 29; 414(6863):555-8. PMID: 11734857.
    Citations: 123     Fields:    Translation:HumansCells
  39. Coyne MJ, Tzianabos AO, Mallory BC, Carey VJ, Kasper DL, Comstock LE. Polysaccharide biosynthesis locus required for virulence of Bacteroides fragilis. Infect Immun. 2001 Jul; 69(7):4342-50. PMID: 11401972.
    Citations: 46     Fields:    Translation:AnimalsCells
  40. Coyne MJ, Kalka-Moll W, Tzianabos AO, Kasper DL, Comstock LE. Bacteroides fragilis NCTC9343 produces at least three distinct capsular polysaccharides: cloning, characterization, and reassignment of polysaccharide B and C biosynthesis loci. Infect Immun. 2000 Nov; 68(11):6176-81. PMID: 11035722.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  41. Comstock LE, Coyne MJ, Tzianabos AO, Kasper DL. Interstrain variation of the polysaccharide B biosynthesis locus of Bacteroides fragilis: characterization of the region from strain 638R. J Bacteriol. 1999 Oct; 181(19):6192-6. PMID: 10498737.
    Citations: 13     Fields:    Translation:Cells
  42. Dean CR, Franklund CV, Retief JD, Coyne MJ, Hatano K, Evans DJ, Pier GB, Goldberg JB. Characterization of the serogroup O11 O-antigen locus of Pseudomonas aeruginosa PA103. J Bacteriol. 1999 Jul; 181(14):4275-84. PMID: 10400585.
    Citations: 35     Fields:    Translation:Cells
  43. Comstock LE, Coyne MJ, Tzianabos AO, Pantosti A, Onderdonk AB, Kasper DL. Analysis of a capsular polysaccharide biosynthesis locus of Bacteroides fragilis. Infect Immun. 1999 Jul; 67(7):3525-32. PMID: 10377135.
    Citations: 28     Fields:    Translation:AnimalsCells
  44. Coyne MJ, Goldberg JB. Cloning and characterization of the gene (rfc) encoding O-antigen polymerase of Pseudomonas aeruginosa PAO1. Gene. 1995 Dec 29; 167(1-2):81-6. PMID: 8566816.
    Citations: 7     Fields:    Translation:Cells
  45. Goldberg JB, Coyne MJ, Neely AN, Holder IA. Avirulence of a Pseudomonas aeruginosa algC mutant in a burned-mouse model of infection. Infect Immun. 1995 Oct; 63(10):4166-9. PMID: 7558335.
    Citations: 21     Fields:    Translation:AnimalsCells
  46. Evans DJ, Pier GB, Coyne MJ, Goldberg JB. The rfb locus from Pseudomonas aeruginosa strain PA103 promotes the expression of O antigen by both LPS-rough and LPS-smooth isolates from cystic fibrosis patients. Mol Microbiol. 1994 Aug; 13(3):427-34. PMID: 7527892.
    Citations: 15     Fields:    Translation:HumansCells
  47. Coyne MJ, Russell KS, Coyle CL, Goldberg JB. The Pseudomonas aeruginosa algC gene encodes phosphoglucomutase, required for the synthesis of a complete lipopolysaccharide core. J Bacteriol. 1994 Jun; 176(12):3500-7. PMID: 7515870.
    Citations: 63     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.