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Murugaiyan Gopal, Ph.D.



The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI151953 (GOPAL, MURUGAIYAN) Mar 1, 2020 - Feb 28, 2025
    The pathogenic role of miR-92a in the regulation of T helper cell responses in EAE and MS
    Role: Principal Investigator
  2. R01AI127853 (GOPAL, MURUGAIYAN) Feb 1, 2017 - Jan 31, 2022
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Murugaiyan G, Fujiwara M, Garo LP. Remyelination-Promoting Inflammation: Novel Role for MyD88 Signaling in Microglia/Macrophages. Trends Neurosci. 2020 Jul; 43(7):455-457. PMID: 32362400.
  2. Fujiwara M, Garo LP, Murugaiyan G. PD1 Blockade in Cancer: Impact on Myeloid Cells. Trends Cancer. 2020 Jun; 6(6):443-444. PMID: 32459997.
  3. Garo LP, Ajay AK, Fujiwara M, Beynon V, Kuhn C, Gabriely G, Sadhukan S, Raheja R, Rubino S, Weiner HL, Murugaiyan G. Smad7 Controls Immunoregulatory PDL2/1-PD1 Signaling in Intestinal Inflammation and Autoimmunity. Cell Rep. 2019 09 24; 28(13):3353-3366.e5. PMID: 31553906.
  4. Gabriely G, da Cunha AP, Rezende RM, Kenyon B, Madi A, Vandeventer T, Skillin N, Rubino S, Garo L, Mazzola MA, Kolypetri P, Lanser AJ, Moreira T, Faria AMC, Lassmann H, Kuchroo V, Murugaiyan G, Weiner HL. Targeting latency-associated peptide promotes antitumor immunity. Sci Immunol. 2017 May 19; 2(11). PMID: 28763794.
    Citations: 3     Fields:    
  5. Garo LP, Beynon V, Murugaiyan G. Flow Cytometric Assessment of STAT Molecules in Th9 Cells. Methods Mol Biol. 2017; 1585:127-140. PMID: 28477192.
    Citations:    Fields:    Translation:Cells
  6. Goettel JA, Gandhi R, Kenison JE, Yeste A, Murugaiyan G, Sambanthamoorthy S, Griffith AE, Patel B, Shouval DS, Weiner HL, Snapper SB, Quintana FJ. AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice. Cell Rep. 2016 10 25; 17(5):1318-1329. PMID: 27783946.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  7. Garo LP, Murugaiyan G. Contribution of MicroRNAs to autoimmune diseases. Cell Mol Life Sci. 2016 May; 73(10):2041-51. PMID: 26943802.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  8. Garo LP, Murugaiyan G. The Use of MiRNA Antagonists in the Alleviation of Inflammatory Disorders. Methods Mol Biol. 2016; 1390:413-25. PMID: 26803642.
    Citations: 1     Fields:    Translation:Animals
  9. Mazzola MA, Raheja R, Murugaiyan G, Rajabi H, Kumar D, Pertel T, Regev K, Griffin R, Aly L, Kivisakk P, Nejad P, Patel B, Gwanyalla N, Hei H, Glanz B, Chitnis T, Weiner HL, Gandhi R. Identification of a novel mechanism of action of fingolimod (FTY720) on human effector T cell function through TCF-1 upregulation. J Neuroinflammation. 2015 Dec 30; 12:245. PMID: 26714756.
    Citations: 5     Fields:    Translation:HumansCells
  10. Butovsky O, Jedrychowski MP, Cialic R, Murugaiyan G, Wu PM, Doykan CE, Fanek Z, Greco DJ, Kiner O, Lawson RJ, Frosch MP, Pochet N, Krichevsky AM, Gygi SP, Berry J, Cudkowicz ME, Weiner HL. Targeting miR-155 restores dysfunctional microglia and ameliorates disease in the SOD1 model of ALS. Int J Dev Neurosci. 2015 Dec; 47(Pt A):5. PMID: 26531345.
  11. Farez MF, Mascanfroni ID, Méndez-Huergo SP, Yeste A, Murugaiyan G, Garo LP, Balbuena Aguirre ME, Patel B, Ysrraelit MC, Zhu C, Kuchroo VK, Rabinovich GA, Quintana FJ, Correale J. Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses. Cell. 2015 Sep 10; 162(6):1338-52. PMID: 26359987.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  12. Murugaiyan G, da Cunha AP, Ajay AK, Joller N, Garo LP, Kumaradevan S, Yosef N, Vaidya VS, Weiner HL. MicroRNA-21 promotes Th17 differentiation and mediates experimental autoimmune encephalomyelitis. J Clin Invest. 2015 Mar 02; 125(3):1069-80. PMID: 25642768.
    Citations: 42     Fields:    Translation:AnimalsCells
  13. Murugaiyan G, Garo LP, Weiner HL. MicroRNA-21, T helper lineage and autoimmunity. Oncotarget. 2015; 6(12):9644-5. PMID: 25991670.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  14. Butovsky O, Jedrychowski MP, Cialic R, Krasemann S, Murugaiyan G, Fanek Z, Greco DJ, Wu PM, Doykan CE, Kiner O, Lawson RJ, Frosch MP, Pochet N, Fatimy RE, Krichevsky AM, Gygi SP, Lassmann H, Berry J, Cudkowicz ME, Weiner HL. Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice. Ann Neurol. 2015 Jan; 77(1):75-99. PMID: 25381879.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  15. Wu C, Pot C, Apetoh L, Thalhamer T, Zhu B, Murugaiyan G, Xiao S, Lee Y, Rangachari M, Yosef N, Kuchroo VK. Metallothioneins negatively regulate IL-27-induced type 1 regulatory T-cell differentiation. Proc Natl Acad Sci U S A. 2013 May 07; 110(19):7802-7. PMID: 23630250.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  16. Murugaiyan G, Saha B. IL-27 in tumor immunity and immunotherapy. Trends Mol Med. 2013 Feb; 19(2):108-16. PMID: 23306374.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  17. Murugaiyan G, Beynon V, Pires Da Cunha A, Joller N, Weiner HL. IFN-? limits Th9-mediated autoimmune inflammation through dendritic cell modulation of IL-27. J Immunol. 2012 Dec 01; 189(11):5277-83. PMID: 23125412.
    Citations: 20     Fields:    Translation:AnimalsCells
  18. Butovsky O, Siddiqui S, Gabriely G, Lanser AJ, Dake B, Murugaiyan G, Doykan CE, Wu PM, Gali RR, Iyer LK, Lawson R, Berry J, Krichevsky AM, Cudkowicz ME, Weiner HL. Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS. J Clin Invest. 2012 Sep; 122(9):3063-87. PMID: 22863620.
    Citations: 138     Fields:    Translation:HumansAnimalsCells
  19. Mittal A, Murugaiyan G, Beynon V, Hu D, Weiner HL. IL-27 induction of IL-21 from human CD8+ T cells induces granzyme B in an autocrine manner. Immunol Cell Biol. 2012 Sep; 90(8):831-5. PMID: 22430249.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  20. Murugaiyan G, Beynon V, Mittal A, Joller N, Weiner HL. Silencing microRNA-155 ameliorates experimental autoimmune encephalomyelitis. J Immunol. 2011 Sep 01; 187(5):2213-21. PMID: 21788439.
    Citations: 108     Fields:    Translation:AnimalsCells
  21. Quintana FJ, Murugaiyan G, Farez MF, Mitsdoerffer M, Tukpah AM, Burns EJ, Weiner HL. An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2010 Nov 30; 107(48):20768-73. PMID: 21068375.
    Citations: 118     Fields:    Translation:AnimalsCells
  22. Murugaiyan G, Mittal A, Weiner HL. Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation. Proc Natl Acad Sci U S A. 2010 Jun 22; 107(25):11495-500. PMID: 20534530.
    Citations: 41     Fields:    Translation:AnimalsCells
  23. Martin S, Agarwal R, Murugaiyan G, Saha B. CD40 expression levels modulate regulatory T cells in Leishmania donovani infection. J Immunol. 2010 Jul 01; 185(1):551-9. PMID: 20525887.
    Citations: 22     Fields:    Translation:AnimalsCells
  24. Ilan Y, Maron R, Tukpah AM, Maioli TU, Murugaiyan G, Yang K, Wu HY, Weiner HL. Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice. Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9765-70. PMID: 20445103.
    Citations: 85     Fields:    Translation:AnimalsCells
  25. Murugaiyan G, Saha B. Protumor vs antitumor functions of IL-17. J Immunol. 2009 Oct 01; 183(7):4169-75. PMID: 19767566.
    Citations: 113     Fields:    Translation:HumansAnimalsCells
  26. Ilan Y, Zigmond E, Lalazar G, Dembinsky A, Ben Ya'acov A, Hemed N, Kasis I, Axelrod E, Zolotarov L, Klein A, El Haj M, Gandhi R, Baecher-Allan C, Wu H, Murugaiyan G, Kivisakk P, Farez MF, Quintana FJ, Khoury SJ, Weiner HL. Oral administration of OKT3 monoclonal antibody to human subjects induces a dose-dependent immunologic effect in T cells and dendritic cells. J Clin Immunol. 2010 Jan; 30(1):167-77. PMID: 19756989.
    Citations: 21     Fields:    Translation:HumansCellsCTClinical Trials
  27. Murugaiyan G, Mittal A, Lopez-Diego R, Maier LM, Anderson DE, Weiner HL. IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T cells. J Immunol. 2009 Aug 15; 183(4):2435-43. PMID: 19625647.
    Citations: 90     Fields:    Translation:HumansCells
  28. Murugaiyan G, Mittal A, Weiner HL. Increased osteopontin expression in dendritic cells amplifies IL-17 production by CD4+ T cells in experimental autoimmune encephalomyelitis and in multiple sclerosis. J Immunol. 2008 Dec 01; 181(11):7480-8. PMID: 19017937.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  29. Awasthi A, Murugaiyan G, Kuchroo VK. Interplay between effector Th17 and regulatory T cells. J Clin Immunol. 2008 Nov; 28(6):660-70. PMID: 18810613.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  30. Vaknin-Dembinsky A, Murugaiyan G, Hafler DA, Astier AL, Weiner HL. Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple sclerosis. J Neuroimmunol. 2008 Mar; 195(1-2):140-5. PMID: 18403025.
    Citations: 19     Fields:    Translation:HumansCells
  31. Murugaiyan G, Martin S, Saha B. CD40-induced countercurrent conduits for tumor escape or elimination? Trends Immunol. 2007 Nov; 28(11):467-73. PMID: 17981086.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  32. Murugaiyan G, Martin S, Saha B. Levels of CD40 expression on dendritic cells dictate tumour growth or regression. Clin Exp Immunol. 2007 Jul; 149(1):194-202. PMID: 17488293.
    Citations: 2     Fields:    Translation:AnimalsCells
  33. Balasubramaniyan V, Shukla R, Murugaiyan G, Bhonde RR, Nalini N. Mouse recombinant leptin protects human hepatoma HepG2 against apoptosis, TNF-alpha response and oxidative stress induced by the hepatotoxin-ethanol. Biochim Biophys Acta. 2007 Aug; 1770(8):1136-44. PMID: 17543459.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  34. Balasubramaniyan V, Murugaiyan G, Shukla R, Bhonde RR, Nalini N. Leptin downregulates ethanol-induced secretion of proinflammatory cytokines and growth factor. Cytokine. 2007 Jan; 37(1):96-100. PMID: 17391979.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  35. Murugaiyan G, Agrawal R, Mishra GC, Mitra D, Saha B. Differential CD40/CD40L expression results in counteracting antitumor immune responses. J Immunol. 2007 Feb 15; 178(4):2047-55. PMID: 17277108.
    Citations: 7     Fields:    Translation:AnimalsCells
  36. Murugaiyan G, Agrawal R, Mishra GC, Mitra D, Saha B. Functional dichotomy in CD40 reciprocally regulates effector T cell functions. J Immunol. 2006 Nov 15; 177(10):6642-9. PMID: 17082576.
    Citations: 8     Fields:    Translation:AnimalsCells
  37. Murugaiyan G, Basak S, Saha B. Reversal of tumor induced dendritic cell paralysis: A treatment regimen against cancer.Curr Immunol rev. 2006; 2(3):261-272.
  38. Murugaiyan G, Basak S, Saha B. Dendritic cell based immunotherapy: A promising approach for treatment of cancer. Gene Ther Mol Biol. 2005; 9:343-358.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.