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Aldebaran Hofer, Ph.D.

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University of California at Berkeley, Berkeley, CA USAPh.D.05/1993Physiology

The Hofer laboratory applies a wide range of molecular, biophysical and fluorescence imaging techniques for probing interactions between two fundamental second messengers, cyclic AMP (cAMP) and calcium. Her team discovered a new signal transduction pathway that connects calcium levels within the ER lumen to the activation of the enzyme that generates cAMP, adenylyl cyclase. Her group has also devised approaches to monitor and tune cAMP in various subcellular compartments using targeted genetically encoded sensors and tools.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. I01BX005124 (HOFER, ALDEBARAN M) Oct 1, 2020 - Sep 30, 2024
    Harnessing the potential of GPCRs localized to the primary cilium for the treatment of renal disease
    Role: Principal Investigator
  2. IS1BX004786 (HOFER, ALDEBARAN M) Jan 1, 2019 - Sep 30, 2019
    ShEEP Request for Leica SP8 Confocal Microscope with Light Sheet
    Role: Principal Investigator
  3. I21BX004093 (HOFER, ALDEBARAN M) Apr 4, 2018 - Mar 31, 2020
    The ciliopathy-tauopathy connection in neurodegenerative disorders
    Role: Principal Investigator
  4. R21DE025921 (HOFER, ALDEBARAN M) Apr 1, 2016 - Mar 31, 2018
    Probing the cAMP signaling microdomain of the primary cilium
    Role: Principal Investigator
  5. I01BX000968 (HOFER, ALDEBARAN M) Apr 1, 2011 - Mar 31, 2015
    Novel STIM1-dependent cyclic AMP signaling pathway in colonic epithelial function
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Arena DT, Hofer AM. Imaging the cAMP Signaling Microdomain of the Primary Cilium Using Targeted FRET-Based Biosensors. Methods Mol Biol. 2022; 2483:77-92. PMID: 35286670.
    Citations:    Fields:    Translation:Cells
  2. Hofer AM. The Love Story between Orai Calcium Entry Channels and Adenylyl Cyclases Gets even more Complicated. Function (Oxf). 2021; 2(5):zqab044. PMID: 35330952; PMCID: PMC8788800.
  3. Arena DT, Hofer AM. Cyclic AMP does double duty to support parallel signaling in primary cilium and cytosol. Cell Calcium. 2021 07; 97:102436. PMID: 34214760; PMCID: PMC8407273.
    Citations:    Fields:    Translation:AnimalsCells
  4. Kitamura Y, Kanaya N, Moleirinho S, Du W, Reinshagen C, Attia N, Bronisz A, Revai Lechtich E, Sasaki H, Mora JL, Brastianos PK, Falcone JL, Hofer AM, Franco A, Shah K. Anti-EGFR VHH-armed death receptor ligand-engineered allogeneic stem cells have therapeutic efficacy in diverse brain metastatic breast cancers. Sci Adv. 2021 03; 7(10). PMID: 33658202; PMCID: PMC7929513.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  5. Ambudkar IS, Hofer AM. Editorial overview: Calcium signaling. Curr Opin Physiol. 2020 Oct; 17:iii-v. PMID: 34532609; PMCID: PMC8442716.
  6. Hofer AM. cAMPing out with the keepers of the gate: Adenylyl cyclases get cozy with Orai. Cell Calcium. 2019 09; 82:102054. PMID: 31402061.
    Citations: 3     Fields:    Translation:Cells
  7. Jiang JY, Falcone JL, Curci S, Hofer AM. Direct visualization of cAMP signaling in primary cilia reveals up-regulation of ciliary GPCR activity following Hedgehog activation. Proc Natl Acad Sci U S A. 2019 06 11; 116(24):12066-12071. PMID: 31142652; PMCID: PMC6575585.
    Citations: 22     Fields:    Translation:AnimalsCells
  8. Kuo IY, Brill AL, Lemos FO, Jiang JY, Falcone JL, Kimmerling EP, Cai Y, Dong K, Kaplan DL, Wallace DP, Hofer AM, Ehrlich BE. Polycystin 2 regulates mitochondrial Ca2+ signaling, bioenergetics, and dynamics through mitofusin 2. Sci Signal. 2019 05 07; 12(580). PMID: 31064883; PMCID: PMC6855602.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  9. Jiang JY, Falcone JL, Curci S, Hofer AM. Interrogating cyclic AMP signaling using optical approaches. Cell Calcium. 2017 06; 64:47-56. PMID: 28274483.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  10. Colella M, Gerbino A, Hofer AM, Curci S. Recent advances in understanding the extracellular calcium-sensing receptor. F1000Res. 2016; 5. PMID: 27803801.
    Citations: 8     Fields:    
  11. Nichols JM, Maiellaro I, Abi-Jaoude J, Curci S, Hofer AM. "Store-operated" cAMP signaling contributes to Ca2+-activated Cl- secretion in T84 colonic cells. Am J Physiol Gastrointest Liver Physiol. 2015 Oct 15; 309(8):G670-9. PMID: 26316590; PMCID: PMC4609931.
    Citations: 5     Fields:    Translation:HumansCells
  12. Hofer AM. Ca²? signaling at membrane contact sites. Cell Calcium. 2015 Oct; 58(4):331-2. PMID: 26248790.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  13. Lefkimmiatis K, Leronni D, Hofer AM. The inner and outer compartments of mitochondria are sites of distinct cAMP/PKA signaling dynamics. J Cell Biol. 2013 Aug 05; 202(3):453-62. PMID: 23897891.
    Citations: 62     Fields:    Translation:HumansCells
  14. Maiellaro I, Lefkimmiatis K, Moyer MP, Curci S, Hofer AM. Termination and activation of store-operated cyclic AMP production. J Cell Mol Med. 2012 Nov; 16(11):2715-25. PMID: 22681560.
    Citations: 12     Fields:    Translation:HumansCells
  15. Cardone A, Lopez F, Affortunato F, Busco G, Hofer AM, Mallamaci R, Martinelli C, Colella M, Farinola GM. An aryleneethynylene fluorophore for cell membrane staining. Biochim Biophys Acta. 2012 Nov; 1818(11):2808-17. PMID: 22749749.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  16. Murakami T, Ockinger J, Yu J, Byles V, McColl A, Hofer AM, Horng T. Critical role for calcium mobilization in activation of the NLRP3 inflammasome. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):11282-7. PMID: 22733741.
    Citations: 334     Fields:    Translation:AnimalsCells
  17. Hofer AM. Interactions between calcium and cAMP signaling. Curr Med Chem. 2012; 19(34):5768-73. PMID: 22963560.
    Citations: 19     Fields:    Translation:HumansCells
  18. Schwarzer C, Wong S, Shi J, Matthes E, Illek B, Ianowski JP, Arant RJ, Isacoff E, Vais H, Foskett JK, Maiellaro I, Hofer AM, Machen TE. Pseudomonas aeruginosa Homoserine lactone activates store-operated cAMP and cystic fibrosis transmembrane regulator-dependent Cl- secretion by human airway epithelia. J Biol Chem. 2010 Nov 05; 285(45):34850-63. PMID: 20739289.
    Citations: 21     Fields:    Translation:HumansCells
  19. Roy J, Lefkimmiatis K, Moyer MP, Curci S, Hofer AM. The {omega}-3 fatty acid eicosapentaenoic acid elicits cAMP generation in colonic epithelial cells via a "store-operated" mechanism. Am J Physiol Gastrointest Liver Physiol. 2010 Sep; 299(3):G715-22. PMID: 20576916.
    Citations: 9     Fields:    Translation:HumansCells
  20. Lefkimmiatis K, Moyer MP, Curci S, Hofer AM. "cAMP sponge": a buffer for cyclic adenosine 3', 5'-monophosphate. PLoS One. 2009 Nov 03; 4(11):e7649. PMID: 19888343.
    Citations: 16     Fields:    Translation:HumansCells
  21. Lefkimmiatis K, Srikanthan M, Maiellaro I, Moyer MP, Curci S, Hofer AM. Store-operated cyclic AMP signalling mediated by STIM1. Nat Cell Biol. 2009 Apr; 11(4):433-42. PMID: 19287379.
    Citations: 91     Fields:    Translation:HumansCells
  22. Zou J, Hofer AM, Lurtz MM, Gadda G, Ellis AL, Chen N, Huang Y, Holder A, Ye Y, Louis CF, Welshhans K, Rehder V, Yang JJ. Developing sensors for real-time measurement of high Ca2+ concentrations. Biochemistry. 2007 Oct 30; 46(43):12275-88. PMID: 17924653.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  23. Hofer AM, Lefkimmiatis K. Extracellular calcium and cAMP: second messengers as "third messengers"? Physiology (Bethesda). 2007 Oct; 22:320-7. PMID: 17928545.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  24. Hofer AM. Review series on the extracellular Ca(2+)-sensing receptor. J Cell Mol Med. 2007 Sep-Oct; 11(5):906-7. PMID: 17979872.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  25. Gerbino A, Fistetto G, Colella M, Hofer AM, Debellis L, Caroppo R, Curci S. Real time measurements of water flow in amphibian gastric glands: modulation via the extracellular Ca2+-sensing receptor. J Biol Chem. 2007 May 04; 282(18):13477-86. PMID: 17363364.
    Citations: 3     Fields:    Translation:AnimalsCells
  26. Hofer AM. Measurement of free [Ca2+] changes in agonist-sensitive internal stores using compartmentalized fluorescent indicators. Methods Mol Biol. 2006; 312:229-47. PMID: 16422202.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  27. Gerbino A, Ruder WC, Curci S, Pozzan T, Zaccolo M, Hofer AM. Termination of cAMP signals by Ca2+ and G(alpha)i via extracellular Ca2+ sensors: a link to intracellular Ca2+ oscillations. J Cell Biol. 2005 Oct 24; 171(2):303-12. PMID: 16247029; PMCID: PMC2171199.
    Citations: 26     Fields:    Translation:HumansCells
  28. Hofer AM. Another dimension to calcium signaling: a look at extracellular calcium. J Cell Sci. 2005 Mar 01; 118(Pt 5):855-62. PMID: 15731003.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  29. Lau BW, Colella M, Ruder WC, Ranieri M, Curci S, Hofer AM. Deoxycholic acid activates protein kinase C and phospholipase C via increased Ca2+ entry at plasma membrane. Gastroenterology. 2005 Mar; 128(3):695-707. PMID: 15765405.
    Citations: 16     Fields:    Translation:HumansCells
  30. Hofer AM. Measurement of free [Ca²+] changes in agonist-sensitive internal stores using compartmentalized fluorescent indicators. Methods Mol Biol. 2005; 312:229-47. PMID: 21341103.
    Citations:    Fields:    Translation:AnimalsCells
  31. Caroppo R, Gerbino A, Fistetto G, Colella M, Debellis L, Hofer AM, Curci S. Extracellular calcium acts as a "third messenger" to regulate enzyme and alkaline secretion. J Cell Biol. 2004 Jul 05; 166(1):111-9. PMID: 15240573; PMCID: PMC2172151.
    Citations: 9     Fields:    Translation:AnimalsCells
  32. Hofer AM, Gerbino A, Caroppo R, Curci S. The extracellular calcium-sensing receptor and cell-cell signaling in epithelia. Cell Calcium. 2004 Mar; 35(3):297-306. PMID: 15200154.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  33. Gerbino A, Hofer AM, McKay B, Lau BW, Soybel DI. Divalent cations regulate acidity within the lumen and tubulovesicle compartment of gastric parietal cells. Gastroenterology. 2004 Jan; 126(1):182-95. PMID: 14699499.
    Citations: 9     Fields:    Translation:AnimalsCells
  34. Caroppo R, Colella M, Colasuonno A, DeLuisi A, Debellis L, Curci S, Hofer AM. A reassessment of the effects of luminal [Ca2+] on inositol 1,4,5-trisphosphate-induced Ca2+ release from internal stores. J Biol Chem. 2003 Oct 10; 278(41):39503-8. PMID: 12888563.
    Citations: 15     Fields:    Translation:AnimalsCells
  35. Hofer AM, Brown EM. Extracellular calcium sensing and signalling. Nat Rev Mol Cell Biol. 2003 Jul; 4(7):530-8. PMID: 12838336.
    Citations: 197     Fields:    Translation:HumansAnimalsCells
  36. De Luisi A, Hofer AM. Evidence that Ca(2+) cycling by the plasma membrane Ca(2+)-ATPase increases the 'excitability' of the extracellular Ca(2+)-sensing receptor. J Cell Sci. 2003 Apr 15; 116(Pt 8):1527-38. PMID: 12640037.
    Citations: 13     Fields:    Translation:HumansCells
  37. Caroppo R, Gerbino A, Debellis L, Kifor O, Soybel DI, Brown EM, Hofer AM, Curci S. Asymmetrical, agonist-induced fluctuations in local extracellular [Ca(2+)] in intact polarized epithelia. EMBO J. 2001 Nov 15; 20(22):6316-26. PMID: 11707403; PMCID: PMC125728.
    Citations: 17     Fields:    Translation:AnimalsCells
  38. Hofer AM, Curci S, Doble MA, Brown EM, Soybel DI. Intercellular communication mediated by the extracellular calcium-sensing receptor. Nat Cell Biol. 2000 Jul; 2(7):392-8. PMID: 10878803.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  39. Hayakawa H, Hofer A, Thelander L, Kitajima S, Cai Y, Oshiro S, Yakushiji H, Nakabeppu Y, Kuwano M, Sekiguchi M. Metabolic fate of oxidized guanine ribonucleotides in mammalian cells. Biochemistry. 1999 Mar 23; 38(12):3610-4. PMID: 10090747.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  40. Hofer AM. Measurement of free [Ca2+] changes in agonist-sensitive internal stores using compartmentalized fluorescent indicators. Methods Mol Biol. 1999; 114:249-65. PMID: 10081023.
    Citations: 6     Fields:    Translation:Animals
  41. Landolfi B, Curci S, Debellis L, Pozzan T, Hofer AM. Ca2+ homeostasis in the agonist-sensitive internal store: functional interactions between mitochondria and the ER measured In situ in intact cells. J Cell Biol. 1998 Sep 07; 142(5):1235-43. PMID: 9732284; PMCID: PMC2149340.
    Citations: 58     Fields:    Translation:AnimalsCells
  42. Hofer AM, Landolfi B, Debellis L, Pozzan T, Curci S. Free [Ca2+] dynamics measured in agonist-sensitive stores of single living intact cells: a new look at the refilling process. EMBO J. 1998 Apr 01; 17(7):1986-95. PMID: 9524121; PMCID: PMC1170544.
    Citations: 27     Fields:    Translation:AnimalsCells
  43. Hofer AM, Fasolato C, Pozzan T. Capacitative Ca2+ entry is closely linked to the filling state of internal Ca2+ stores: a study using simultaneous measurements of ICRAC and intraluminal [Ca2+]. J Cell Biol. 1998 Jan 26; 140(2):325-34. PMID: 9442108; PMCID: PMC2132570.
    Citations: 74     Fields:    Translation:AnimalsCells
  44. Hofer AM, Schulz I. Quantification of intraluminal free [Ca] in the agonist-sensitive internal calcium store using compartmentalized fluorescent indicators: some considerations. Cell Calcium. 1996 Sep; 20(3):235-42. PMID: 8894270.
    Citations: 20     Fields:    Translation:AnimalsCells
  45. Hofer AM, Curci S, Machen TE, Schulz I. ATP regulates calcium leak from agonist-sensitive internal calcium stores. FASEB J. 1996 Feb; 10(2):302-8. PMID: 8641563.
    Citations: 23     Fields:    Translation:AnimalsCells
  46. Hofer AM, Schlue WR, Curci S, Machen TE. Spatial distribution and quantitation of free luminal [Ca] within the InsP3-sensitive internal store of individual BHK-21 cells: ion dependence of InsP3-induced Ca release and reloading. FASEB J. 1995 Jun; 9(9):788-98. PMID: 7601343.
    Citations: 21     Fields:    Translation:AnimalsCells
  47. Hofer AM, Machen TE. Direct measurement of free Ca in organelles of gastric epithelial cells. Am J Physiol. 1994 Sep; 267(3 Pt 1):G442-51. PMID: 7943242.
    Citations: 13     Fields:    Translation:AnimalsCells
  48. Hofer AM, Machen TE. Technique for in situ measurement of calcium in intracellular inositol 1,4,5-trisphosphate-sensitive stores using the fluorescent indicator mag-fura-2. Proc Natl Acad Sci U S A. 1993 Apr 01; 90(7):2598-602. PMID: 8464866; PMCID: PMC46142.
    Citations: 57     Fields:    Translation:AnimalsCells
  49. Hofer AM, Machen TE. K-induced alkalinization in all cell types of rabbit gastric glands: a novel K/H exchange mechanism. J Membr Biol. 1992 Mar; 126(3):245-56. PMID: 1629906.
    Citations: 5     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.