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profileKonstantina Stankovic, M.D., PH.D.

TitleAssociate Professor of Otolaryngology
InstitutionMassachusetts Eye and Ear Infirmary
DepartmentOtolaryngology
AddressMassachusetts Eye & Ear Infirmary
Otolaryngology
243 Charles St
Boston MA 02114
Phone6175733972
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Collapse Overview 
Collapse overview
The focus of my research has been on hearing and understanding how the inner ear environment contributes to normal function of the auditory nerve. The long-term goal has been to restore hearing through regeneration and novel technologies. I began my research in hearing as an undergraduate student and have maintained a focus in this area since.

My clinical practice is limited to otology, neurotology and skull base surgery. Working in a multidisciplinary, tertiary referral center, I care for patients with the highest level of clinical complexity.

Throughout my career, I have played a role in the education and training of undergraduate students at M.I.T., medical students at Harvard, graduate student from the Harvard-M.I.T. Division of Health Sciences and Technology, residents in otolaryngology – head and neck surgery at Harvard and postdoctoral research fellows.


Collapse Mentoring 
Collapse completed student projects
Genetic Determinants of the Uniqueness of Schwann Cells of the Vestibular Nerve
Summer, 06/14/10 - 08/02/10
Quantitative Polarized Light Microscopy of Mammalian Cochlear Sections
Summer, 06/20/11 - 08/12/11

Collapse Research 
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01DC015824     (STANKOVIC, KONSTANTINA M)Sep 13, 2016 - Aug 31, 2021
NIH/NIDCD
Mechanisms of sensorineural hearing loss: secreted factors
Role: Principal Investigator

K08DC010419     (STANKOVIC, KONSTANTINA M)Dec 15, 2009 - Nov 30, 2014
NIH/NIDCD
Understanding Noise-Induced Delayed Primary Degeneration of the Auditory Nerve
Role: Principal Investigator

Collapse Bibliographic 
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Yip M, Bowers P, Noel V, Chandrakasan A, Stankovic KM. Energy-efficient waveform for electrical stimulation of the cochlear nerve. Sci Rep. 2017 Oct 19; 7(1):13582. PMID: 29051546.
    View in: PubMed
  2. Ren Y, Sagers JE, Landegger LD, Bhatia SN, Stankovic KM. Tumor-Penetrating Delivery of siRNA against TNFa to Human Vestibular Schwannomas. Sci Rep. 2017 Oct 10; 7(1):12922. PMID: 29018206.
    View in: PubMed
  3. Landegger LD, Lee JD, Linthicum FH, Stankovic KM. Cochlear Dysfunction is not Common in Human Meningioma of the Internal Auditory Canal. Otol Neurotol. 2017 Oct 04. PMID: 28984808.
    View in: PubMed
  4. Maxfield AZ, Landegger LD, Brook CD, Lehmann AE, Campbell AP, Bergmark RW, Stankovic KM, Metson R. Periostin as a Biomarker for Nasal Polyps in Chronic Rhinosinusitis. Otolaryngol Head Neck Surg. 2017 Oct 01; 194599817737967. PMID: 29040053.
    View in: PubMed
  5. Sagers JE, Landegger LD, Worthington S, Nadol JB, Stankovic KM. Human Cochlear Histopathology Reflects Clinical Signatures of Primary Neural Degeneration. Sci Rep. 2017 Jul 07; 7(1):4884. PMID: 28687782.
    View in: PubMed
  6. Sahin MI, Sagers JE, Stankovic KM. Cochlear Implantation: Vast Unmet Need to Address Deafness Globally. Otol Neurotol. 2017 Jul; 38(6):786-787. PMID: 28437361.
    View in: PubMed
  7. Lin BM, Li WQ, Curhan SG, Stankovic KM, Qureshi AA, Curhan GC. Skin Pigmentation and Risk of Hearing Loss in Women. Am J Epidemiol. 2017 Jul 01; 186(1):1-10. PMID: 28525626.
    View in: PubMed
  8. Landegger LD, Sagers JE, Dilwali S, Fujita T, Sahin MI, Stankovic KM. A Unified Methodological Framework for Vestibular Schwannoma Research. J Vis Exp. 2017 Jun 20; (124). PMID: 28654042.
    View in: PubMed
  9. Landegger LD, Dilwali S, Stankovic KM. Neonatal Murine Cochlear Explant Technique as an In Vitro Screening Tool in Hearing Research. J Vis Exp. 2017 Jun 08; (124). PMID: 28654047.
    View in: PubMed
  10. Landegger LD, Pan B, Askew C, Wassmer SJ, Gluck SD, Galvin A, Taylor R, Forge A, Stankovic KM, Holt JR, Vandenberghe LH. A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear. Nat Biotechnol. 2017 Mar; 35(3):280-284. PMID: 28165475.
    View in: PubMed
  11. Lin BM, Curhan SG, Wang M, Jacobson BC, Eavey R, Stankovic KM, Curhan GC. Prospective Study of Gastroesophageal Reflux, Use of Proton Pump Inhibitors and H2-Receptor Antagonists, and Risk of Hearing Loss. Ear Hear. 2017 Jan/Feb; 38(1):21-27. PMID: 27556519.
    View in: PubMed
  12. Lin BM, Curhan SG, Wang M, Eavey R, Stankovic KM, Curhan GC. Duration of Analgesic Use and Risk of Hearing Loss in Women. Am J Epidemiol. 2017 Jan 01; 185(1):40-47. PMID: 27974293.
    View in: PubMed
  13. Kim BG, Fujita T, Stankovic KM, Welling DB, Moon IS, Choi JY, Yun J, Kang JS, Lee JD. Sulforaphane, a natural component of broccoli, inhibits vestibular schwannoma growth in vitro and in vivo. Sci Rep. 2016 Nov 02; 6:36215. PMID: 27805058.
    View in: PubMed
  14. Kandathil CK, Cunnane ME, McKenna MJ, Curtin HD, Stankovic KM. Correlation Between Aspirin Intake and Reduced Growth of Human Vestibular Schwannoma: Volumetric Analysis. Otol Neurotol. 2016 Oct; 37(9):1428-34. PMID: 27631829.
    View in: PubMed
  15. Iyer JS, Batts SA, Chu KK, Sahin MI, Leung HM, Tearney GJ, Stankovic KM. Micro-optical coherence tomography of the mammalian cochlea. Sci Rep. 2016 Sep 16; 6:33288. PMID: 27633610; PMCID: PMC5025881.
  16. Fujita T, Shin JE, Cunnane M, Fujita K, Henein S, Psaltis D, Stankovic KM. Surgical Anatomy of the Human Round Window Region: Implication for Cochlear Endoscopy Through the External Auditory Canal. Otol Neurotol. 2016 Sep; 37(8):1189-94. PMID: 27228017.
    View in: PubMed
  17. Brook CD, Maxfield AZ, Stankovic K, Metson RB. The Impact of Angiotensin-Modulating Antihypertensives on Time Interval to Revision Surgery for Nasal Polyps. Otolaryngol Head Neck Surg. 2016 Dec; 155(6):1046-1052. PMID: 27554516.
    View in: PubMed
  18. Soares VY, Atai NA, Fujita T, Dilwali S, Sivaraman S, Landegger LD, Hochberg FH, Oliveira CA, Bahmad F, Breakefield XO, Stankovic KM. Extracellular vesicles derived from human vestibular schwannomas associated with poor hearing damage cochlear cells. Neuro Oncol. 2016 Nov; 18(11):1498-1507. PMID: 27194145.
    View in: PubMed
  19. Groth JB, Kao SY, Briët MC, Stankovic KM. Hepatocyte nuclear factor-4 alpha in noise-induced cochlear neuropathy. Dev Neurobiol. 2016 Dec; 76(12):1374-1386. PMID: 27112738.
    View in: PubMed
  20. West JS, Low JC, Stankovic KM. Revealing Hearing Loss: A Survey of How People Verbally Disclose Their Hearing Loss. Ear Hear. 2016 Mar-Apr; 37(2):194-205. PMID: 26513208.
    View in: PubMed
  21. Landegger LD, Psaltis D, Stankovic KM. Human audiometric thresholds do not predict specific cellular damage in the inner ear. Hear Res. 2016 May; 335:83-93. PMID: 26924453.
    View in: PubMed
  22. Kao SY, Soares VY, Kristiansen AG, Stankovic KM. Activation of TRAIL-DR5 pathway promotes sensorineural degeneration in the inner ear. Aging Cell. 2016 Apr; 15(2):301-8. PMID: 26791792; PMCID: PMC4783338.
  23. Dilwali S, Landegger LD, Soares VY, Deschler DG, Stankovic KM. Secreted Factors from Human Vestibular Schwannomas Can Cause Cochlear Damage. Sci Rep. 2015 Dec 22; 5:18599. PMID: 26690506; PMCID: PMC4686978.
  24. Lin BM, Curhan SG, Wang M, Eavey R, Stankovic KM, Curhan GC. Hypertension, Diuretic Use, and Risk of Hearing Loss. Am J Med. 2016 Apr; 129(4):416-22. PMID: 26656761; PMCID: PMC4792671 [Available on 04/01/17].
  25. Stankovic KM, Tan OT, Sadow PM. CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 36-2015. A 27-Year-Old Woman with a Lesion of the Ear Canal. N Engl J Med. 2015 Nov 19; 373(21):2070-7. PMID: 26581000.
    View in: PubMed
  26. Curhan SG, Stankovic KM, Eavey RD, Wang M, Stampfer MJ, Curhan GC. Carotenoids, vitamin A, vitamin C, vitamin E, and folate and risk of self-reported hearing loss in women. Am J Clin Nutr. 2015 Nov; 102(5):1167-75. PMID: 26354537; PMCID: PMC4625586 [Available on 11/01/16].
  27. Kao SY, Stankovic KM. Transactivation of human osteoprotegerin promoter by GATA-3. Sci Rep. 2015 Jul 28; 5:12479. PMID: 26216189; PMCID: PMC4516985.
  28. Jensen JB, Lysaght AC, Liberman MC, Qvortrup K, Stankovic KM. Immediate and delayed cochlear neuropathy after noise exposure in pubescent mice. PLoS One. 2015; 10(5):e0125160. PMID: 25955832; PMCID: PMC4425526.
  29. Dilwali S, Briët MC, Kao SY, Fujita T, Landegger LD, Platt MP, Stankovic KM. Preclinical validation of anti-nuclear factor-kappa B therapy to inhibit human vestibular schwannoma growth. Mol Oncol. 2015 Aug; 9(7):1359-70. PMID: 25891780; PMCID: PMC4523465.
  30. Low JC, Ober TJ, McKinley GH, Stankovic KM. Quantitative polarized light microscopy of human cochlear sections. Biomed Opt Express. 2015 Feb 01; 6(2):599-606. PMID: 25780749; PMCID: PMC4354578.
  31. Dilwali S, Kao SY, Fujita T, Landegger LD, Stankovic KM. Nonsteroidal anti-inflammatory medications are cytostatic against human vestibular schwannomas. Transl Res. 2015 Jul; 166(1):1-11. PMID: 25616959; PMCID: PMC4458444.
  32. Dilwali S, Roberts D, Stankovic KM. Interplay between VEGF-A and cMET signaling in human vestibular schwannomas and schwann cells. Cancer Biol Ther. 2015; 16(1):170-5. PMID: 25692621; PMCID: PMC4622023.
  33. Yip M, Jin R, Nakajima HH, Stankovic KM, Chandrakasan AP. A Fully-Implantable Cochlear Implant SoC with Piezoelectric Middle-Ear Sensor and Arbitrary Waveform Neural Stimulation. IEEE J Solid-State Circuits. 2015 Jan 01; 50(1):214-229. PMID: 26251552.
    View in: PubMed
  34. Balasubramanian R, Choi JH, Francescatto L, Willer J, Horton ER, Asimacopoulos EP, Stankovic KM, Plummer L, Buck CL, Quinton R, Nebesio TD, Mericq V, Merino PM, Meyer BF, Monies D, Gusella JF, Al Tassan N, Katsanis N, Crowley WF. Functionally compromised CHD7 alleles in patients with isolated GnRH deficiency. Proc Natl Acad Sci U S A. 2014 Dec 16; 111(50):17953-8. PMID: 25472840; PMCID: PMC4273325.
  35. Bandyopadhyay S, Mercier PP, Lysaght AC, Stankovic KM, Chandrakasan AP. A 1.1nW Energy Harvesting System with 544pW Quiescent Power for Next Generation Implants. IEEE J Solid-State Circuits. 2014 Dec; 49(12):2812-2824. PMID: 25983340.
    View in: PubMed
  36. Lysaght AC, Yuan Q, Fan Y, Kalwani N, Caruso P, Cunnane M, Lanske B, Stankovic KM. FGF23 deficiency leads to mixed hearing loss and middle ear malformation in mice. PLoS One. 2014; 9(9):e107681. PMID: 25243481; PMCID: PMC4171482.
  37. Robertson NG, O'Malley JT, Ong CA, Giersch AB, Shen J, Stankovic KM, Morton CC. Cochlin in normal middle ear and abnormal middle ear deposits in DFNA9 and Coch (G88E/G88E) mice. J Assoc Res Otolaryngol. 2014 Dec; 15(6):961-74. PMID: 25049087; PMCID: PMC4389958.
  38. Mercier PP, Bandyopadhyay S, Lysaght AC, Stankovic KM, Chandrakasan AP. A sub-nW 2.4 GHz Transmitter for Low Data-Rate Sensing Applications. IEEE J Solid-State Circuits. 2014 Jul; 49(7):1463-1474. PMID: 26246641.
    View in: PubMed
  39. Dilwali S, Patel PB, Roberts DS, Basinsky GM, Harris GJ, Emerick KS, Stankovic KM. Primary culture of human Schwann and schwannoma cells: improved and simplified protocol. Hear Res. 2014 Sep; 315:25-33. PMID: 24910344; PMCID: PMC4164296.
  40. Kandathil CK, Dilwali S, Wu CC, Ibrahimov M, McKenna MJ, Lee H, Stankovic KM. Aspirin intake correlates with halted growth of sporadic vestibular schwannoma in vivo. Otol Neurotol. 2014 Feb; 35(2):353-7. PMID: 24448296.
    View in: PubMed
  41. Muurling T, Stankovic KM. Metabolomic and network analysis of pharmacotherapies for sensorineural hearing loss. Otol Neurotol. 2014 Jan; 35(1):1-6. PMID: 24335929.
    View in: PubMed
  42. Platt M, Dilwali S, Elackattu A, Parikh JR, Stankovic KM. Mining immune epitopes in the inner ear. Otolaryngol Head Neck Surg. 2014 Mar; 150(3):460-3. PMID: 24367049.
    View in: PubMed
  43. Stamatiou GA, Stankovic KM. A comprehensive network and pathway analysis of human deafness genes. Otol Neurotol. 2013 Jul; 34(5):961-70. PMID: 23770690.
    View in: PubMed
  44. Dilwali S, Lysaght A, Roberts D, Barker FG, McKenna MJ, Stankovic KM. Sporadic vestibular schwannomas associated with good hearing secrete higher levels of fibroblast growth factor 2 than those associated with poor hearing irrespective of tumor size. Otol Neurotol. 2013 Jun; 34(4):748-54. PMID: 23512073; PMCID: PMC3655133.
  45. Kao SY, Kempfle JS, Jensen JB, Perez-Fernandez D, Lysaght AC, Edge AS, Stankovic KM. Loss of osteoprotegerin expression in the inner ear causes degeneration of the cochlear nerve and sensorineural hearing loss. Neurobiol Dis. 2013 Aug; 56:25-33. PMID: 23607938; PMCID: PMC3752395.
  46. Yang X, Pu Y, Hsieh CL, Ong CA, Psaltis D, Stankovic KM. Two-photon microscopy of the mouse cochlea in situ for cellular diagnosis. J Biomed Opt. 2013 Mar; 18(3):031104. PMID: 23520652.
    View in: PubMed
  47. Yang X, Pu Y, Hsieh CL, Ong CA, Psaltis D, Stankovic KM. Two-photon microscopy of the mouse cochlea in situ for cellular diagnosis. J Biomed Opt. 2013 Mar; 18(3):31104. PMID: 23165736.
    View in: PubMed
  48. Kalwani NM, Ong CA, Lysaght AC, Haward SJ, McKinley GH, Stankovic KM. Quantitative polarized light microscopy of unstained mammalian cochlear sections. J Biomed Opt. 2013 Feb; 18(2):26021. PMID: 23407909; PMCID: PMC3571355.
  49. Stankovic KM, Eskandar E, El Khoury JB, Lev MH, Sadow PM. Case records of the Massachusetts General Hospital. Case 2-2013. A 20-year-old man with recurrent ear pain, fever, and headache. N Engl J Med. 2013 Jan 17; 368(3):267-77. PMID: 23323904.
    View in: PubMed
  50. Mercier PP, Lysaght AC, Bandyopadhyay S, Chandrakasan AP, Stankovic KM. Energy extraction from the biologic battery in the inner ear. Nat Biotechnol. 2012 Dec; 30(12):1240-3. PMID: 23138225; PMCID: PMC3938019.
  51. Lysaght AC, Kao SY, Paulo JA, Merchant SN, Steen H, Stankovic KM. Proteome of human perilymph. J Proteome Res. 2011 Sep 02; 10(9):3845-51. PMID: 21740021; PMCID: PMC3179892.
  52. Lin HW, Roberts DS, Kay J, Stankovic KM. Sensorineural hearing loss following imatinib (Gleevec) administration. Otolaryngol Head Neck Surg. 2012 Feb; 146(2):335-7. PMID: 21753034.
    View in: PubMed
  53. Platt MP, Soler ZM, Kao SY, Metson R, Stankovic KM. Topographic gene expression in the sinonasal cavity of patients with chronic sinusitis with polyps. Otolaryngol Head Neck Surg. 2011 Jul; 145(1):171-5. PMID: 21493287; PMCID: PMC3752390.
  54. Platt MP, Soler Z, Metson R, Stankovic KM. Pathways analysis of molecular markers in chronic sinusitis with polyps. Otolaryngol Head Neck Surg. 2011 May; 144(5):802-8. PMID: 21493366; PMCID: PMC4164309.
  55. Stankovic KM, Hennessey AM, Herrmann B, Mankarious LA. Cochlear implantation in children with congenital X-linked deafness due to novel mutations in POU3F4 gene. Ann Otol Rhinol Laryngol. 2010 Dec; 119(12):815-22. PMID: 21250553.
    View in: PubMed
  56. Stankovic KM, Juliano AF, Hasserjian RP. Case records of the Massachusetts General Hospital. Case 36-2010. A 50-year-old woman with pain and loss of hearing in the left ear. N Engl J Med. 2010 Nov 25; 363(22):2146-56. PMID: 21105797.
    View in: PubMed
  57. Gómez-Casati ME, Murtie JC, Rio C, Stankovic K, Liberman MC, Corfas G. Nonneuronal cells regulate synapse formation in the vestibular sensory epithelium via erbB-dependent BDNF expression. Proc Natl Acad Sci U S A. 2010 Sep 28; 107(39):17005-10. PMID: 20837532; PMCID: PMC2947909.
  58. Stankovic KM, Adachi O, Tsuji K, Kristiansen AG, Adams JC, Rosen V, McKenna MJ. Differences in gene expression between the otic capsule and other bones. Hear Res. 2010 Jun 14; 265(1-2):83-9. PMID: 20146935; PMCID: PMC3586807.
  59. Stankovic KM, Mrugala MM, Martuza RL, Silver M, Betensky RA, Nadol JB, Stemmer-Rachamimov AO. Genetic determinants of hearing loss associated with vestibular schwannomas. Otol Neurotol. 2009 Aug; 30(5):661-7. PMID: 19546833.
    View in: PubMed
  60. Platt M, Metson R, Stankovic K. Gene-expression signatures of nasal polyps associated with chronic rhinosinusitis and aspirin-sensitive asthma. Curr Opin Allergy Clin Immunol. 2009 Feb; 9(1):23-8. PMID: 19532090.
    View in: PubMed
  61. Stankovic KM, Goldsztein H, Reh DD, Platt MP, Metson R. Gene expression profiling of nasal polyps associated with chronic sinusitis and aspirin-sensitive asthma. Laryngoscope. 2008 May; 118(5):881-9. PMID: 18391768.
    View in: PubMed
  62. Stankovic KM, Kristiansen AG, Bizaki A, Lister M, Adams JC, McKenna MJ. Studies of otic capsule morphology and gene expression in the Mov13 mouse--an animal model of type I osteogenesis imperfecta. Audiol Neurootol. 2007; 12(5):334-43. PMID: 17595534.
    View in: PubMed
  63. Sugawara M, Murtie JC, Stankovic KM, Liberman MC, Corfas G. Dynamic patterns of neurotrophin 3 expression in the postnatal mouse inner ear. J Comp Neurol. 2007 Mar 01; 501(1):30-7. PMID: 17206617.
    View in: PubMed
  64. Stankovic KM, McKenna MJ. Current research in otosclerosis. Curr Opin Otolaryngol Head Neck Surg. 2006 Oct; 14(5):347-51. PMID: 16974150.
    View in: PubMed
  65. Stankovic K, Rio C, Xia A, Sugawara M, Adams JC, Liberman MC, Corfas G. Survival of adult spiral ganglion neurons requires erbB receptor signaling in the inner ear. J Neurosci. 2004 Oct 06; 24(40):8651-61. PMID: 15470130.
    View in: PubMed
  66. Stankovic KM, Corfas G. Real-time quantitative RT-PCR for low-abundance transcripts in the inner ear: analysis of neurotrophic factor expression. Hear Res. 2003 Nov; 185(1-2):97-108. PMID: 14599697.
    View in: PubMed
  67. Stankovic KM, Guinan JJ. Medial efferent effects on auditory-nerve responses to tail-frequency tones II: alteration of phase. J Acoust Soc Am. 2000 Aug; 108(2):664-78. PMID: 10955633.
    View in: PubMed
  68. Stankovic KM, Guinan JJ. Medial efferent effects on auditory-nerve responses to tail-frequency tones. I. Rate reduction. J Acoust Soc Am. 1999 Aug; 106(2):857-69. PMID: 10462791.
    View in: PubMed
  69. Stankovic KM, Brown D, Alper SL, Adams JC. Localization of pH regulating proteins H+ATPase and Cl-/HCO3- exchanger in the guinea pig inner ear. Hear Res. 1997 Dec; 114(1-2):21-34. PMID: 9447915.
    View in: PubMed
  70. Guinan JJ, Stankovic KM. Medial efferent inhibition produces the largest equivalent attenuations at moderate to high sound levels in cat auditory-nerve fibers. J Acoust Soc Am. 1996 Sep; 100(3):1680-90. PMID: 8817894.
    View in: PubMed
  71. Stankovic KM, Adams JC, Brown D. Immunolocalization of aquaporin CHIP in the guinea pig inner ear. Am J Physiol. 1995 Dec; 269(6 Pt 1):C1450-6. PMID: 8572173.
    View in: PubMed
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