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Kai-Christian Sonntag, Ph.D., M.D.

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Mentoring
Available: 12/01/18, Expires: 12/31/20

Our lab studies a role of bioenergetics in Alzheimer's disease (AD). It is well known that metabolic changes are associated with the normal aging process, and our research aims to understand how these changes are linked to sporadic/late-onset AD (LOAD) pathogenesis. For this, we have developed a cell-based platform using fibroblasts and blood cells from LOAD patients and healthy control individuals to generate induced pluripotent stem cells (iPSC) and induced neurons (iN). iPSCs are differentiated to neurons and astrocytes and together with iNs are analyzed for their bioenergetic profiles and changes in metabolism, as a function of age and disease. The goal of our program is to establish a 'personalized medicine approach' aiming to understand AD pathogenesis and to develop biomarkers or testing novel therapeutic strategies. The student's role will be to participate in and learn the principles of the iPSC and iN paradigms in context of neurodifferentiation and -degeneration with a focus on AD. There are several subprojects within the scope of the main studies which focus on particular aspects of the cellular bioenergetics and metabolic functions in the aging process and LOAD. In addition, we are studying other cellular functions related to metabolic dysfunction in LOAD, and we identify and test the effects of therapeutic molecules in our model system. The student will be involved in study design, experimental data generation, analyses, interpretation, and summarizing results in scientific reports.

Available: 09/01/19, Expires: 12/31/20

Our lab is interested in studying a role of bioenergetics in Alzheimer's disease (AD). It is well known that metabolic changes are associated with the normal aging process, and our research aims to understand how these changes are linked to AD pathogenesis. For this, we have developed a cell-based platform using fibroblasts and blood cells from AD patients and healthy control individuals to generate induced pluripotent stem cells (iPSC) and induced neurons (iN). iPSCs are differentiated to neurons and astrocytes and together with iNs are analyzed for their bioenergetic profiles and changes in metabolism, as a function of age and disease. The goal of our program is to establish a 'personalized medicine approach' aiming to understand AD pathogenesis and to develop and test novel therapeutic strategies.

The student's role will be to participate in and learn the principles of the iPSC and iN paradigms in context of neurodifferentiation and -degeneration with a focus on AD. There are several subprojects within the scope of the main studies which focus on particular aspects of the cellular bioenergetics and metabolic functions in the aging process and AD. In addition, we are studying other cellular functions related to metabolic dysfunction in AD, and we identify and test the effects of therapeutic molecules in our model system. The student is expected to conduct a ‘thesis project’ that includes study design, experimental data generation, analyses, interpretation, and summary of a scientific report.


Bibliographic
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  1. Jeong YI, Kim T, Hwang EJ, Kim SW, Sonntag KC, Kim DH, Koh JW. Reactive oxygen species-sensitive nanophotosensitizers of aminophenyl boronic acid pinacol ester conjugated chitosan-g-methoxy poly(ethylene glycol) copolymer for photodynamic treatment of cancer. Biomed Mater. 2020 Jun 11. PMID: 32526727.
    Citations:    
  2. Meda S, Freund N, Norman KJ, Thompson BS, Sonntag KC, Andersen SL. The use of laser capture microdissection to identify specific pathways and mechanisms involved in impulsive choice in rats. Heliyon. 2019 Aug; 5(8):e02254. PMID: 31485508.
    Citations:    
  3. El Fatimy R, Li S, Chen Z, Mushannen T, Gongala S, Wei Z, Balu DT, Rabinovsky R, Cantlon A, Elkhal A, Selkoe DJ, Sonntag KC, Walsh DM, Krichevsky AM. MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways. Acta Neuropathol. 2018 10; 136(4):537-555. PMID: 29982852.
    Citations:    Fields:    
  4. Sonntag KC, Song B, Lee N, Jung JH, Cha Y, Leblanc P, Neff C, Kong SW, Carter BS, Schweitzer J, Kim KS. Pluripotent stem cell-based therapy for Parkinson's disease: Current status and future prospects. Prog Neurobiol. 2018 09; 168:1-20. PMID: 29653250.
    Citations:    Fields:    
  5. Kohlbrenner EA, Shaskan N, Pietersen CY, Sonntag KC, Woo TW. Gene expression profile associated with postnatal development of pyramidal neurons in the human prefrontal cortex implicates ubiquitin ligase E3 in the pathophysiology of schizophrenia onset. J Psychiatr Res. 2018 07; 102:110-117. PMID: 29635114.
    Citations:    Fields:    
  6. Mauney SA, Woo TW, Sonntag KC. Cell Type-Specific Laser Capture Microdissection for Gene Expression Profiling in the Human Brain. Methods Mol Biol. 2018; 1723:203-221. PMID: 29344862.
    Citations:    Fields:    Translation:HumansCells
  7. Sonntag KC, Woo TW. Laser microdissection and gene expression profiling in the human postmortem brain. Handb Clin Neurol. 2018; 150:263-272. PMID: 29496145.
    Citations:    Fields:    Translation:Humans
  8. Sonntag KC, Ryu WI, Amirault KM, Healy RA, Siegel AJ, McPhie DL, Forester B, Cohen BM. Late-onset Alzheimer's disease is associated with inherent changes in bioenergetics profiles. Sci Rep. 2017 10 25; 7(1):14038. PMID: 29070876.
    Citations: 1     Fields:    
  9. Chmielarz P, Konovalova J, Najam SS, Alter H, Piepponen TP, Erfle H, Sonntag KC, Schütz G, Vinnikov IA, Domanskyi A. Dicer and microRNAs protect adult dopamine neurons. Cell Death Dis. 2017 05 25; 8(5):e2813. PMID: 28542144.
    Citations: 6     Fields:    Translation:AnimalsCells
  10. Lukkes JL, Sonntag KC, Freund N, Thompson BS, Meda S, Andersen SL. Erratum to "Preventative treatment in an animal model of DHD: Behavioral and biochemical effects of methylphenidate and its interactions with ovarian hormones in female rats" [Eur. Neuropsychopharmacol. 26 (2016) 1496-1506]. Eur Neuropsychopharmacol. 2016 11; 26(11):1843. PMID: 28236417.
    Citations:    Fields:    
  11. Sonntag KC, Tejada G, Subburaju S, Berretta S, Benes FM, Woo TU. Limited predictability of postmortem human brain tissue quality by RNA integrity numbers. J Neurochem. 2016 07; 138(1):53-9. PMID: 27062510.
    Citations: 3     Fields:    Translation:HumansCells
  12. Freund N, Thompson BS, Sonntag K, Meda S, Andersen SL. When the party is over: depressive-like states in rats following termination of cortical D1 receptor overexpression. Psychopharmacology (Berl). 2016 Apr; 233(7):1191-201. PMID: 26762379.
    Citations: 7     Fields:    Translation:AnimalsCells
  13. Mauney SA, Pietersen CY, Sonntag KC, Woo TW. Differentiation of oligodendrocyte precursors is impaired in the prefrontal cortex in schizophrenia. Schizophr Res. 2015 Dec; 169(1-3):374-380. PMID: 26585218.
    Citations: 8     Fields:    Translation:HumansCells
  14. Briggs CE, Wang Y, Kong B, Woo TU, Iyer LK, Sonntag KC. Midbrain dopamine neurons in Parkinson's disease exhibit a dysregulated miRNA and target-gene network. Brain Res. 2015 Aug 27; 1618:111-21. PMID: 26047984.
    Citations: 10     Fields:    Translation:HumansCells
  15. Brenhouse HC, Thompson BS, Sonntag KC, Andersen SL. Extinction and reinstatement to cocaine-associated cues in male and female juvenile rats and the role of D1 dopamine receptor. Neuropharmacology. 2015 Aug; 95:22-8. PMID: 25749358.
    Citations: 2     Fields:    Translation:AnimalsCells
  16. Frederick AL, Yano H, Trifilieff P, Vishwasrao HD, Biezonski D, Mészáros J, Urizar E, Sibley DR, Kellendonk C, Sonntag KC, Graham DL, Colbran RJ, Stanwood GD, Javitch JA. Evidence against dopamine D1/D2 receptor heteromers. Mol Psychiatry. 2015 Nov; 20(11):1373-85. PMID: 25560761.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  17. Kim W, Noh H, Lee Y, Jeon J, Shanmugavadivu A, McPhie DL, Kim KS, Cohen BM, Seo H, Sonntag KC. MiR-126 Regulates Growth Factor Activities and Vulnerability to Toxic Insult in Neurons. Mol Neurobiol. 2016 Jan; 53(1):95-108. PMID: 25407931.
    Citations: 5     Fields:    Translation:AnimalsCells
  18. Castaño J, Menendez P, Bruzos-Cidon C, Straccia M, Sousa A, Zabaleta L, Vazquez N, Zubiarrain A, Sonntag KC, Ugedo L, Carvajal-Vergara X, Canals JM, Torrecilla M, Sanchez-Pernaute R, Giorgetti A. Fast and efficient neural conversion of human hematopoietic cells. Stem Cell Reports. 2014 Dec 09; 3(6):1118-31. PMID: 25458894.
    Citations: 5     Fields:    Translation:HumansCells
  19. Aguila JC, Blak A, van Arensbergen J, Sousa A, Vázquez N, Aduriz A, Gayosso M, Lopez Mato MP, Lopez de Maturana R, Hedlund E, Sonntag KC, Sanchez-Pernaute R. Selection Based on FOXA2 Expression Is Not Sufficient to Enrich for Dopamine Neurons From Human Pluripotent Stem Cells. Stem Cells Transl Med. 2014 Sep; 3(9):1032-42. PMID: 25024431.
    Citations: 5     Fields:    Translation:HumansCells
  20. Pietersen CY, Mauney SA, Kim SS, Lim MP, Rooney RJ, Goldstein JM, Petryshen TL, Seidman LJ, Shenton ME, McCarley RW, Sonntag KC, Woo TU. Molecular profiles of pyramidal neurons in the superior temporal cortex in schizophrenia. J Neurogenet. 2014 Mar-Jun; 28(1-2):53-69. PMID: 24702465.
    Citations: 18     Fields:    Translation:HumansCells
  21. Pietersen CY, Mauney SA, Kim SS, Passeri E, Lim MP, Rooney RJ, Goldstein JM, Petreyshen TL, Seidman LJ, Shenton ME, Mccarley RW, Sonntag KC, Woo TU. Molecular profiles of parvalbumin-immunoreactive neurons in the superior temporal cortex in schizophrenia. J Neurogenet. 2014 Mar-Jun; 28(1-2):70-85. PMID: 24628518.
    Citations: 18     Fields:    Translation:HumansCells
  22. Kim W, Lee Y, McKenna ND, Yi M, Simunovic F, Wang Y, Kong B, Rooney RJ, Seo H, Stephens RM, Sonntag KC. miR-126 contributes to Parkinson's disease by dysregulating the insulin-like growth factor/phosphoinositide 3-kinase signaling. Neurobiol Aging. 2014 Jul; 35(7):1712-21. PMID: 24559646.
    Citations: 18     Fields:    Translation:HumansCells
  23. Andersen SL, Sonntag KC. Juvenile methylphenidate reduces prefrontal cortex plasticity via D3 receptor and BDNF in adulthood. Front Synaptic Neurosci. 2014; 6:1. PMID: 24478696.
    Citations: 10     
  24. Sonntag KC, Brenhouse HC, Freund N, Thompson BS, Puhl M, Andersen SL. Viral over-expression of D1 dopamine receptors in the prefrontal cortex increase high-risk behaviors in adults: comparison with adolescents. Psychopharmacology (Berl). 2014 Apr; 231(8):1615-26. PMID: 24408208.
    Citations: 18     Fields:    Translation:AnimalsCells
  25. Abelman M, O'Rourke PP, Sonntag KC. Part-human animal research: the imperative to move beyond a philosophical debate. Am J Bioeth. 2012; 12(9):26-8. PMID: 22881849.
    Citations:    Fields:    Translation:HumansAnimals
  26. Sonntag KC, Woo TU, Krichevsky AM. Converging miRNA functions in diverse brain disorders: a case for miR-124 and miR-126. Exp Neurol. 2012 Jun; 235(2):427-35. PMID: 22178324.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  27. Chartoff EH, Damez-Werno D, Sonntag KC, Hassinger L, Kaufmann DE, Peterson J, McPhie D, Cataldo AM, Cohen BM. Detection of intranasally delivered bone marrow-derived mesenchymal stromal cells in the lesioned mouse brain: a cautionary report. Stem Cells Int. 2011; 2011:586586. PMID: 22190964.
    Citations: 6     
  28. Pietersen CY, Lim MP, Macey L, Woo TU, Sonntag KC. Neuronal type-specific gene expression profiling and laser-capture microdissection. Methods Mol Biol. 2011; 755:327-43. PMID: 21761317.
    Citations: 16     Fields:    Translation:HumansCells
  29. Andersen SL, Greene-Colozzi EA, Sonntag KC. A novel, multiple symptom model of obsessive-compulsive-like behaviors in animals. Biol Psychiatry. 2010 Oct 15; 68(8):741-7. PMID: 20619828.
    Citations: 16     Fields:    Translation:Animals
  30. Sonntag KC. MicroRNAs and deregulated gene expression networks in neurodegeneration. Brain Res. 2010 Jun 18; 1338:48-57. PMID: 20380815.
    Citations: 44     Fields:    Translation:HumansAnimals
  31. Sonntag KC, Wahlestedt C. RNA mechanisms in CNS systems and disorders. Brain Res. 2010 Jun 18; 1338:1-2. PMID: 20380824.
    Citations: 1     Fields:    Translation:HumansAnimals
  32. Simunovic F, Yi M, Wang Y, Stephens R, Sonntag KC. Evidence for gender-specific transcriptional profiles of nigral dopamine neurons in Parkinson disease. PLoS One. 2010 Jan 25; 5(1):e8856. PMID: 20111594.
    Citations: 41     Fields:    Translation:HumansCells
  33. Sonntag KC, Simunovic F, Sanchez-Pernaute R. Stem cells and cell replacement therapy for Parkinson's disease. J Neural Transm Suppl. 2009; (73):287-99. PMID: 20411787.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  34. Simunovic F, Yi M, Wang Y, Macey L, Brown LT, Krichevsky AM, Andersen SL, Stephens RM, Benes FM, Sonntag KC. Gene expression profiling of substantia nigra dopamine neurons: further insights into Parkinson's disease pathology. Brain. 2009 Jul; 132(Pt 7):1795-809. PMID: 19052140.
    Citations: 97     Fields:    Translation:HumansCells
  35. Sanchez-Pernaute R, Lee H, Patterson M, Reske-Nielsen C, Yoshizaki T, Sonntag KC, Studer L, Isacson O. Parthenogenetic dopamine neurons from primate embryonic stem cells restore function in experimental Parkinson's disease. Brain. 2008 Aug; 131(Pt 8):2127-39. PMID: 18669499.
    Citations: 21     Fields:    Translation:AnimalsCells
  36. Andersen SL, Napierata L, Brenhouse HC, Sonntag KC. Juvenile methylphenidate modulates reward-related behaviors and cerebral blood flow by decreasing cortical D3 receptors. Eur J Neurosci. 2008 Jun; 27(11):2962-72. PMID: 18588536.
    Citations: 18     Fields:    Translation:Animals
  37. Brenhouse HC, Sonntag KC, Andersen SL. Transient D1 dopamine receptor expression on prefrontal cortex projection neurons: relationship to enhanced motivational salience of drug cues in adolescence. J Neurosci. 2008 Mar 05; 28(10):2375-82. PMID: 18322084.
    Citations: 104     Fields:    Translation:AnimalsCells
  38. Brunlid G, Pruszak J, Holmes B, Isacson O, Sonntag KC. Immature and neurally differentiated mouse embryonic stem cells do not express a functional Fas/Fas ligand system. Stem Cells. 2007 Oct; 25(10):2551-8. PMID: 17615270.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  39. Pruszak J, Sonntag KC, Aung MH, Sanchez-Pernaute R, Isacson O. Markers and methods for cell sorting of human embryonic stem cell-derived neural cell populations. Stem Cells. 2007 Sep; 25(9):2257-68. PMID: 17588935.
    Citations: 97     Fields:    Translation:HumansCells
  40. Seo H, Sonntag KC, Kim W, Cattaneo E, Isacson O. Proteasome activator enhances survival of Huntington's disease neuronal model cells. PLoS One. 2007 Feb 28; 2(2):e238. PMID: 17327906.
    Citations: 37     Fields:    Translation:HumansCells
  41. Karki S, Pruszak J, Isacson O, Sonntag KC. ES cell-derived neuroepithelial cell cultures. J Vis Exp. 2006 Nov 30; (1):118. PMID: 18704173.
    Citations: 3     Fields:    Translation:Cells
  42. Sonntag KC, Pruszak J, Yoshizaki T, van Arensbergen J, Sanchez-Pernaute R, Isacson O. Enhanced yield of neuroepithelial precursors and midbrain-like dopaminergic neurons from human embryonic stem cells using the bone morphogenic protein antagonist noggin. Stem Cells. 2007 Feb; 25(2):411-8. PMID: 17038668.
    Citations: 77     Fields:    Translation:HumansAnimalsCells
  43. Sonntag KC, Sanchez-Pernaute R. Tailoring human embryonic stem cells for neurodegenerative disease therapy. Curr Opin Investig Drugs. 2006 Jul; 7(7):614-8. PMID: 16869113.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  44. Krichevsky AM, Sonntag KC, Isacson O, Kosik KS. Specific microRNAs modulate embryonic stem cell-derived neurogenesis. Stem Cells. 2006 Apr; 24(4):857-64. PMID: 16357340.
    Citations: 267     Fields:    Translation:AnimalsCells
  45. Wang YP, Zhao XX, Sonntag K, Wehling P, Snowdon RJ. Behaviour of Sinapis alba chromosomes in a Brassica napus background revealed by genomic in-situ hybridization. Chromosome Res. 2005; 13(8):819-26. PMID: 16331413.
    Citations: 5     Fields:    Translation:AnimalsCells
  46. Sonntag KC. Implementations of translational medicine. J Transl Med. 2005 Aug 30; 3:33. PMID: 16131400.
    Citations: 5     Fields:    
  47. Chung CY, Seo H, Sonntag KC, Brooks A, Lin L, Isacson O. Cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection. Hum Mol Genet. 2005 Jul 01; 14(13):1709-25. PMID: 15888489.
    Citations: 113     Fields:    Translation:AnimalsCells
  48. Sonntag KC, Simantov R, Isacson O. Stem cells may reshape the prospect of Parkinson's disease therapy. Brain Res Mol Brain Res. 2005 Mar 24; 134(1):34-51. PMID: 15790528.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  49. Sonntag KC, Simantov R, Björklund L, Cooper O, Pruszak J, Kowalke F, Gilmartin J, Ding J, Hu YP, Shen MM, Isacson O. Context-dependent neuronal differentiation and germ layer induction of Smad4-/- and Cripto-/- embryonic stem cells. Mol Cell Neurosci. 2005 Mar; 28(3):417-29. PMID: 15737733.
    Citations: 14     Fields:    Translation:AnimalsCells
  50. Seo H, Sonntag KC, Isacson O. Generalized brain and skin proteasome inhibition in Huntington's disease. Ann Neurol. 2004 Sep; 56(3):319-28. PMID: 15349858.
    Citations: 48     Fields:    Translation:Humans
  51. Wang YP, Snowdon RJ, Rudloff E, Wehling P, Friedt W, Sonntag K. Cytogenetic characterization and fae1 gene variation in progenies from asymmetric somatic hybrids between Brassica napus and Crambe abyssinica. Genome. 2004 Aug; 47(4):724-31. PMID: 15284877.
    Citations: 4     Fields:    Translation:AnimalsCells
  52. Sonntag KC, Simantov R, Kim KS, Isacson O. Temporally induced Nurr1 can induce a non-neuronal dopaminergic cell type in embryonic stem cell differentiation. Eur J Neurosci. 2004 Mar; 19(5):1141-52. PMID: 15016073.
    Citations: 19     Fields:    Translation:AnimalsCells
  53. Matter-Reissmann UB, Sonntag KC, Gilli UO, Leguern C, Schneider MK, Seebach JD. Human Fas-ligand expression on porcine endothelial cells does not protect against xenogeneic natural killer cytotoxicity. Xenotransplantation. 2004 Jan; 11(1):43-52. PMID: 14962292.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  54. Wang YP, Sonntag K, Rudloff E. Development of rapeseed with high erucic acid content by asymmetric somatic hybridization between Brassica napus and Crambe abyssinica. Theor Appl Genet. 2003 May; 106(7):1147-55. PMID: 12687349.
    Citations: 15     Fields:    Translation:AnimalsCells
  55. Chung S, Sonntag KC, Andersson T, Bjorklund LM, Park JJ, Kim DW, Kang UJ, Isacson O, Kim KS. Genetic engineering of mouse embryonic stem cells by Nurr1 enhances differentiation and maturation into dopaminergic neurons. Eur J Neurosci. 2002 Nov; 16(10):1829-38. PMID: 12453046.
    Citations: 52     Fields:    Translation:AnimalsCells
  56. Chung S, Andersson T, Sonntag KC, Björklund L, Isacson O, Kim KS. Analysis of different promoter systems for efficient transgene expression in mouse embryonic stem cell lines. Stem Cells. 2002; 20(2):139-45. PMID: 11897870.
    Citations: 42     Fields:    Translation:AnimalsCells
  57. Sonntag KC, Emery DW, Yasumoto A, Haller G, Germana S, Sablinski T, Shimizu A, Yamada K, Shimada H, Arn S, Sachs DH, LeGuern C. Tolerance to solid organ transplants through transfer of MHC class II genes. J Clin Invest. 2001 Jan; 107(1):65-71. PMID: 11134181.
    Citations: 12     Fields:    Translation:AnimalsCells
  58. Sonntag KC, Nebhard N, Haller GW, Yasumoto A, Sachs DH, LeGuern C. Assessment of transduction rates of porcine bone marrow. J Hematother Stem Cell Res. 2000 Oct; 9(5):721-6. PMID: 11091496.
    Citations:    Fields:    Translation:HumansAnimalsCells
  59. Sonntag KC, Haller GW, Giauffret D, Germana S, Reeves SA, Levy J, Sachs DH, LeGuern C. Regulated expression of an MHC class II gene from a promoter-inducible retrovirus. Hum Gene Ther. 2000 Sep 20; 11(14):1961-9. PMID: 11020796.
    Citations: 2     Fields:    Translation:AnimalsCells
  60. Shimada H, Germana S, Sonntag KC, Banerjee P, Moore D, Sachs DH, LeGuern C. MHC class II alpha/beta heterodimeric cell surface molecules expressed from a single proviral genome. Hum Gene Ther. 1999 Sep 20; 10(14):2397-405. PMID: 10515459.
    Citations: 1     Fields:    Translation:AnimalsCells
  61. Sonntag KC, Darai G. Strategy for identifying the gene encoding the DNA polymerase of molluscum contagiosum virus type 1. Virus Genes. 1996; 13(1):31-44. PMID: 8938977.
    Citations:    Fields:    Translation:HumansCells
  62. Sonntag KC, Clauer U, Bugert JJ, Schnitzler P, Darai G. Identification and properties of the genes encoding the poly(A) polymerase and a small (22 kDa) and the largest subunit (147 kDa) of the DNA-dependent RNA polymerase of molluscum contagiosum virus. Virology. 1995 Jul 10; 210(2):471-8. PMID: 7618282.
    Citations: 4     Fields:    Translation:Cells
  63. Sonntag KC, Schwarz-Eywill M, Hunstein W. Is interferon alpha a therapy for hepatitis B-associated polyarteritis nodosa? Br J Rheumatol. 1995 May; 34(5):486-7. PMID: 7788188.
    Citations:    Fields:    Translation:Humans
  64. Sonntag KC, Darai G. Evolution of viral DNA-dependent RNA polymerases. Virus Genes. 1995; 11(2-3):271-84. PMID: 8828152.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  65. Schnitzler P, Sonntag KC, Müller M, Janssen W, Bugert JJ, Koonin EV, Darai G. Insect iridescent virus type 6 encodes a polypeptide related to the largest subunit of eukaryotic RNA polymerase II. J Gen Virol. 1994 Jul; 75 ( Pt 7):1557-67. PMID: 8021587.
    Citations: 8     Fields:    Translation:Cells
  66. Sonntag KC, Schnitzler P, Koonin EV, Darai G. Chilo iridescent virus encodes a putative helicase belonging to a distinct family within the "DEAD/H" superfamily: implications for the evolution of large DNA viruses. Virus Genes. 1994 Mar; 8(2):151-8. PMID: 8073636.
    Citations: 7     Fields:    Translation:Cells
  67. Sonntag KC, Schnitzler P, Janssen W, Darai G. Identification of the primary structure and the coding capacity of the genome of insect iridescent virus type 6 between the genome coordinates 0.310 and 0.347 (7990 bp). Intervirology. 1994; 37(5):287-97. PMID: 7698884.
    Citations: 4     Fields:    Translation:Cells
  68. Sonntag, K.-C. . Identification and Characterization of the Origin of DNA Replication CIV-ori-M and the Transcriptional Activity of Insect Iridescent Virus Type 6 Between the Genome-Coordinates 0.310 to 0.347 (7990 bp). 1994.
  69. Sonntag KC, Darai G. Characterization of the third origin of DNA replication of the genome of insect iridescent virus type 6. Virus Genes. 1992 Nov; 6(4):333-42. PMID: 1475907.
    Citations: 5     Fields:    Translation:Cells
  70. Handermann M, Schnitzler P, Rösen-Wolff A, Raab K, Sonntag KC, Darai G. Identification and mapping of origins of DNA replication within the DNA sequences of the genome of insect iridescent virus type 6. Virus Genes. 1992 Jan; 6(1):19-32. PMID: 1549908.
    Citations: 8     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.