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Can Ozan Tan, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R03NS106444 (TAN, CAN OZAN) Mar 1, 2018 - Feb 29, 2020
    Cerebrovascular Function as a Marker for Optimal Timing and Intensity of Exercise after Concussion
    Role: Principal Investigator
  2. 15SDG23290000 (Can Ozan Tan) Jan 1, 2015 - Jan 31, 2018
    American Heart Association
    Chronic Spinal Cord Injury and Short-Term Control of Cerebral Blood Flow in Humans
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Reilly JM, Gundersen AI, Silver JK, Tan CO, Knowlton SE. A Comparison of Functional Outcomes between Patients Admitted to Inpatient Rehabilitation after Initial Diagnosis Versus Recurrence of Glioblastoma Multiforme. PM R. 2020 Apr 12. PMID: 32281244.
  2. Sheriff F, Diz-Lopes M, Khawaja A, Sorond F, Tan CO, Azevedo E, Franceschini MA, Vaitkevicius H, Li K, Monk AD, Michaud SL, Feske SK, Castro P. Microemboli After Successful Thrombectomy Do Not Affect Outcome but Predict New Embolic Events. Stroke. 2020 01; 51(1):154-161. PMID: 31795906.
  3. Poirot MG, Bergmans RHJ, Thomson BR, Jolink FC, Moum SJ, Gonzalez RG, Lev MH, Tan CO, Gupta R. Physics-informed Deep Learning for Dual-Energy Computed Tomography Image Processing. Sci Rep. 2019 11 27; 9(1):17709. PMID: 31776423.
  4. Mazwi NL, Izzy S, Tan CO, Martinez S, Glenn MB, Giacino JT, Wu O, Zafonte R, Edlow BL. Traumatic Microbleeds in the Hippocampus and Corpus Callosum Predict Duration of Posttraumatic Amnesia. J Head Trauma Rehabil. 2019 Nov/Dec; 34(6):E10-E18. PMID: 31033742.
  5. Howell DR, Taylor JA, Tan CO, Orr R, Meehan WP. The Role of Aerobic Exercise in Reducing Persistent Sport-related Concussion Symptoms. Med Sci Sports Exerc. 2019 04; 51(4):647-652. PMID: 30376513.
    Citations:    Fields:    
  6. Hamner JW, Ishibashi K, Tan CO. Revisiting human cerebral blood flow responses to augmented blood pressure oscillations. J Physiol. 2019 03; 597(6):1553-1564. PMID: 30633356.
    Citations:    Fields:    
  7. Kim DI, Taylor JA, Tan CO, Park H, Kim JY, Park SY, Chung KM, Lee YH, Lee BS, Jeon JY. A pilot randomized controlled trial of 6-week combined exercise program on fasting insulin and fitness levels in individuals with spinal cord injury. Eur Spine J. 2019 05; 28(5):1082-1091. PMID: 30680633.
    Citations:    Fields:    
  8. Tan CO, Lam S, Kuppens D, Bergmans RHJ, Parameswaran BK, Forghani R, Hu R, Daftari Besheli L, Goldstein JN, Thrall J, Lev M, Romero JM, Gupta R. Spot and Diffuse Signs: Quantitative Markers of Intracranial Hematoma Expansion at Dual-Energy CT. Radiology. 2019 01; 290(1):179-186. PMID: 30375929.
    Citations:    Fields:    
  9. Brooks FA, Ughwanogho U, Henderson GV, Black-Schaffer R, Sorond FA, Tan CO. The Link Between Cerebrovascular Hemodynamics and Rehabilitation Outcomes After Aneurysmal Subarachnoid Hemorrhage. Am J Phys Med Rehabil. 2018 05; 97(5):309-315. PMID: 29309312.
    Citations: 1     Fields:    
  10. Cepeda FX, Lapointe M, Tan CO, Andrew Taylor J. Inconsistent relation of nonlinear heart rate variability indices to increasing vagal tone in healthy humans. Auton Neurosci. 2018 Sep; 213:1-7. PMID: 30005735.
    Citations:    Fields:    
  11. Ozturk ED, Tan CO. Human cerebrovascular function in health and disease: insights from integrative approaches. J Physiol Anthropol. 2018 Feb 17; 37(1):4. PMID: 29454381.
    Citations:    Fields:    Translation:Humans
  12. Zafonte RD, Shih SL, Iaccarino MA, Tan CO. Neurologic benefits of sports and exercise. Handb Clin Neurol. 2018; 158:463-471. PMID: 30482373.
    Citations:    Fields:    
  13. Yoshida H, Hamner JW, Ishibashi K, Tan CO. Relative contributions of systemic hemodynamic variables to cerebral autoregulation during orthostatic stress. J Appl Physiol (1985). 2018 02 01; 124(2):321-329. PMID: 29025902.
    Citations: 2     Fields:    
  14. Albalawi T, Hamner JW, Lapointe M, Meehan WP, Tan CO. The Relationship between Cerebral Vasoreactivity and Post-Concussive Symptom Severity. J Neurotrauma. 2017 10 01; 34(19):2700-2705. PMID: 28537493.
    Citations: 2     Fields:    Translation:Humans
  15. Kim DI, Tan CO. Alterations in autonomic cerebrovascular control after spinal cord injury. Auton Neurosci. 2018 01; 209:43-50. PMID: 28416148.
    Citations: 1     Fields:    Translation:HumansAnimals
  16. Daftari Besheli L, Tan CO, Bell DL, Hirsch JA, Gupta R. Temporal evolution of vasospasm and clinical outcome after intra-arterial vasodilator therapy in patients with aneurysmal subarachnoid hemorrhage. PLoS One. 2017; 12(3):e0174676. PMID: 28339483.
    Citations:    Fields:    Translation:Humans
  17. Okafor EC, Gupta R, Estrada D, Andrew Taylor J, Tan CO. FES-Rowing and Long-Term Reversal of Osteoporosis Following Spinal Cord Injury: A Case Study: 699 Board #15 June 1, 3: 30 PM - 5: 00 PM. Med Sci Sports Exerc. 2016 May; 48(5 Suppl 1):186. PMID: 27359842.
  18. Santos GA, Petersen N, Zamani AA, Du R, LaRose S, Monk A, Sorond FA, Tan CO. Pathophysiologic differences in cerebral autoregulation after subarachnoid hemorrhage. Neurology. 2016 05 24; 86(21):1950-6. PMID: 27164675.
    Citations: 7     Fields:    Translation:Humans
  19. Howell DR, Mannix RC, Quinn B, Taylor JA, Tan CO, Meehan WP. Physical Activity Level and Symptom Duration Are Not Associated After Concussion. Am J Sports Med. 2016 Apr; 44(4):1040-6. PMID: 26838933.
    Citations: 2     Fields:    Translation:Humans
  20. Tamisier R, Tan CO, Pepin JL, Levy P, Taylor JA. Blood Pressure Increases in OSA due to Maintained Neurovascular Sympathetic Transduction: Impact of CPAP. Sleep. 2015 Dec 01; 38(12):1973-80. PMID: 26039959.
    Citations: 2     Fields:    Translation:Humans
  21. Sorond FA, Tan CO, LaRose S, Monk AD, Fichorova R, Ryan S, Lipsitz LA. Deferoxamine, Cerebrovascular Hemodynamics, and Vascular Aging: Potential Role for Hypoxia-Inducible Transcription Factor-1-Regulated Pathways. Stroke. 2015 Sep; 46(9):2576-83. PMID: 26304864.
    Citations: 4     Fields:    Translation:HumansCells
  22. Taylor JA, Tan CO, Hamner JW. Assessing cerebral autoregulation via oscillatory lower body negative pressure and projection pursuit regression. J Vis Exp. 2014 Dec 10; (94). PMID: 25549201.
    Citations:    Fields:    Translation:Humans
  23. Gardner AJ, Tan CO, Ainslie PN, van Donkelaar P, Stanwell P, Levi CR, Iverson GL. Cerebrovascular reactivity assessed by transcranial Doppler ultrasound in sport-related concussion: a systematic review. Br J Sports Med. 2015 Aug; 49(16):1050-5. PMID: 25452613.
    Citations: 12     Fields:    Translation:Humans
  24. Tan CO, Meehan WP, Iverson GL, Taylor JA. Cerebrovascular regulation, exercise, and mild traumatic brain injury. Neurology. 2014 Oct 28; 83(18):1665-72. PMID: 25274845.
    Citations: 12     Fields:    Translation:Humans
  25. Tan CO, Hamner JW. Response to letter regarding article, "Relative contributions of sympathetic, cholinergic, and myogenic mechanisms to cerebral autoregulation". Stroke. 2014 Oct; 45(10):e209. PMID: 25116883.
    Citations:    Fields:    Translation:Humans
  26. Tan CO, Battaglino RA, Doherty AL, Gupta R, Lazzari AA, Garshick E, Zafonte R, Morse LR. Adiponectin is associated with bone strength and fracture history in paralyzed men with spinal cord injury. Osteoporos Int. 2014 Nov; 25(11):2599-607. PMID: 24980185.
    Citations: 5     Fields:    Translation:Humans
  27. Hamner JW, Tan CO. Relative contributions of sympathetic, cholinergic, and myogenic mechanisms to cerebral autoregulation. Stroke. 2014 Jun; 45(6):1771-7. PMID: 24723314.
    Citations: 16     Fields:    Translation:Humans
  28. Otite F, Mink S, Tan CO, Puri A, Zamani AA, Mehregan A, Chou S, Orzell S, Purkayastha S, Du R, Sorond FA. Impaired cerebral autoregulation is associated with vasospasm and delayed cerebral ischemia in subarachnoid hemorrhage. Stroke. 2014 Mar; 45(3):677-82. PMID: 24425120.
    Citations: 16     Fields:    Translation:Humans
  29. Tan CO, Taylor JA. Integrative physiological and computational approaches to understand autonomic control of cerebral autoregulation. Exp Physiol. 2014 Jan; 99(1):3-15. PMID: 24097158.
    Citations: 9     Fields:    Translation:HumansAnimals
  30. Taylor JA, Tan CO. BP regulation VI: elevated sympathetic outflow with human aging: hypertensive or homeostatic? Eur J Appl Physiol. 2014 Mar; 114(3):511-9. PMID: 24078210.
    Citations: 1     Fields:    Translation:Humans
  31. Tan CO, Taylor JA. On the judicious use of metrics for cerebral autoregulation. Eur J Appl Physiol. 2013 Nov; 113(11):2867-8. PMID: 24002470.
    Citations: 1     Fields:    Translation:HumansAnimals
  32. Tan CO, Hamner JW, Taylor JA. The role of myogenic mechanisms in human cerebrovascular regulation. J Physiol. 2013 Oct 15; 591(20):5095-105. PMID: 23959681.
    Citations: 23     Fields:    Translation:Humans
  33. Rosenberg PB, Tan CO. Cocoa, neurovascular coupling, and neurodegeneration: the good, the bad, and the ugly. Neurology. 2013 Sep 03; 81(10):863-4. PMID: 23925761.
    Citations:    Fields:    Translation:HumansAnimalsCells
  34. Tan CO. Heart rate variability: are there complex patterns? Front Physiol. 2013; 4:165. PMID: 23847544.
  35. Tan CO, Tzeng YC, Hamner JW, Tamisier R, Taylor JA. Alterations in sympathetic neurovascular transduction during acute hypoxia in humans. Am J Physiol Regul Integr Comp Physiol. 2013 Jun 01; 304(11):R959-65. PMID: 23576610.
    Citations: 2     Fields:    Translation:HumansCells
  36. Tan CO, Tamisier R, Hamner JW, Taylor JA. Characterizing sympathetic neurovascular transduction in humans. PLoS One. 2013; 8(1):e53769. PMID: 23326501.
    Citations: 3     Fields:    Translation:Humans
  37. Tan CO, Battaglino RA, Morse LR. Spinal Cord Injury and Osteoporosis: Causes, Mechanisms, and Rehabilitation Strategies. Int J Phys Med Rehabil. 2013; 1. PMID: 25419534.
    Citations: 4     
  38. Hamner JW, Tan CO, Tzeng YC, Taylor JA. Cholinergic control of the cerebral vasculature in humans. J Physiol. 2012 Dec 15; 590(24):6343-52. PMID: 23070700.
    Citations: 24     Fields:    Translation:HumansCells
  39. Tan CO. Defining the characteristic relationship between arterial pressure and cerebral flow. J Appl Physiol (1985). 2012 Oct 15; 113(8):1194-200. PMID: 22961266.
    Citations: 24     Fields:    Translation:Humans
  40. Tan CO, Taylor JA. Feedback and feedforward sympathetic haemodynamic control: chicken or egg? J Physiol. 2011 Apr 15; 589(Pt 8):1867. PMID: 21498380.
    Citations: 1     Fields:    Translation:HumansAnimals
  41. Callegaro CC, Ribeiro JP, Tan CO, Taylor JA. Attenuated inspiratory muscle metaboreflex in endurance-trained individuals. Respir Physiol Neurobiol. 2011 Jun 30; 177(1):24-9. PMID: 21382525.
    Citations: 6     Fields:    Translation:Humans
  42. Alraek T, Tan CO. Acupuncture and heart rate variability. Acupunct Med. 2011 Mar; 29(1):7-8. PMID: 21317210.
    Citations: 2     Fields:    Translation:Humans
  43. Tan CO, Taylor JA. Does respiratory sinus arrhythmia serve a buffering role for diastolic pressure fluctuations? Am J Physiol Heart Circ Physiol. 2010 May; 298(5):H1492-8. PMID: 20173043.
    Citations: 5     Fields:    Translation:HumansAnimals
  44. Hamner JW, Tan CO, Lee K, Cohen MA, Taylor JA. Sympathetic control of the cerebral vasculature in humans. Stroke. 2010 Jan; 41(1):102-9. PMID: 20007920.
    Citations: 48     Fields:    Translation:Humans
  45. Picard G, Tan CO, Zafonte R, Taylor JA. Incongruous changes in heart period and heart rate variability with vagotonic atropine: implications for rehabilitation medicine. PM R. 2009 Sep; 1(9):820-6. PMID: 19769915.
    Citations: 5     Fields:    Translation:Humans
  46. Bullock D, Tan CO, John YJ. Computational perspectives on forebrain microcircuits implicated in reinforcement learning, action selection, and cognitive control. Neural Netw. 2009 Jul-Aug; 22(5-6):757-65. PMID: 19592218.
    Citations: 3     Fields:    Translation:HumansCells
  47. Tan CO, Cohen MA, Eckberg DL, Taylor JA. Fractal properties of human heart period variability: physiological and methodological implications. J Physiol. 2009 Aug 01; 587(Pt 15):3929-41. PMID: 19528254.
    Citations: 17     Fields:    Translation:HumansCTClinical Trials
  48. Julien C, Parkes MJ, Tzeng SY, Sin PY, Ainslie PN, van de Borne P, Fortrat JO, Custaud MA, Gharib C, Porta A, Vallais F, Baselli G, Pagani M, Lucini D, Hughson RL, Taylor JA, Tan CO, Baekey DM, Dick TE, Paton JF, Taha B. Comments on point:counterpoint: respiratory sinus arrhythmia is due to a central mechanism vs. respiratory sinus arrhythmia is due to the baroreflex mechanism. J Appl Physiol (1985). 2009 May; 106(5):1745-9. PMID: 19414628.
    Citations: 5     Fields:    Translation:HumansAnimals
  49. Tan CO. Anticipatory changes in regional cerebral hemodynamics: a new role for dopamine? J Neurophysiol. 2009 Jun; 101(6):2738-40. PMID: 19321643.
    Citations: 8     Fields:    Translation:HumansAnimals
  50. Tan CO, Taylor JA, Ler AS, Cohen MA. Detection of multifiber neuronal firings: a mixture separation model applied to sympathetic recordings. IEEE Trans Biomed Eng. 2009 Jan; 56(1):147-58. PMID: 19224728.
    Citations: 8     Fields:    Translation:HumansAnimals
  51. Tan CO, Bullock D. A local circuit model of learned striatal and dopamine cell responses under probabilistic schedules of reward. J Neurosci. 2008 Oct 01; 28(40):10062-74. PMID: 18829964.
    Citations: 10     Fields:    
  52. Tan CO, Bullock D. A dopamine-acetylcholine cascade: simulating learned and lesion-induced behavior of striatal cholinergic interneurons. J Neurophysiol. 2008 Oct; 100(4):2409-21. PMID: 18715897.
    Citations: 6     Fields:    Translation:HumansCells
  53. Tan CO, Anderson E, Dranias M, Bullock D. Can the apparent adaptation of dopamine neurons' mismatch sensitivities be reconciled with their computation of reward prediction errors? Neurosci Lett. 2008 Jun 13; 438(1):14-6. PMID: 18482798.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  54. Tan CO, Bullock D. Neuropeptide co-release with GABA may explain functional non-monotonic uncertainty responses in dopamine neurons. Neurosci Lett. 2008 Jan 17; 430(3):218-23. PMID: 18053647.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  55. Cohen MA, Tan CO. Cardiovascular variability is/is not an index of autonomic control of circulation. J Appl Physiol (1985). 2006 08; 101(2):686; author reply 690-1. PMID: 16894646.
    Citations:    Fields:    Translation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.