Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Alan Brent Packard, PH.D.

Title
Institution
Department
Address
Phone
Fax

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R13EB018639 (PACKARD, ALAN BRENT) Apr 1, 2014 - Mar 31, 2015
    NIH/NIBIB
    2014 Metals in Medicine Gordon Research Conference
    Role: Principal Investigator
  2. R01HL108107 (PACKARD, ALAN BRENT) Apr 1, 2011 - Jun 30, 2021
    NIH/NHLBI
    A Novel F-18 PET Myocardial Perfusion Radiopharmaceutical based on Rhodamine Dyes
    Role: Principal Investigator
  3. R01CA094338 (PACKARD, ALAN BRENT) Mar 9, 2004 - Feb 28, 2010
    NIH/NCI
    Functional Imaging of Multidrug Resistance with PET
    Role: Principal Investigator
  4. R21CA081084 (PACKARD, ALAN BRENT) Apr 8, 1999 - Mar 31, 2002
    NIH/NCI
    FUNCTIONAL IMAGING OF MULTIDRUG RESISTANCE WITH PET
    Role: Principal Investigator
  5. R01CA044573 (PACKARD, ALAN BRENT) Jun 1, 1987 - Mar 31, 1991
    NIH/NCI
    DEVELOPMENT OF A 191-OS:191M-IR RADIONUCLIDE GENERATOR
    Role: Principal Investigator
This researcher has shared information about their research resources in the eagle-i Network. To update or add resource records, contact eagle-i@hms.harvard.edu.
Radiopharmaceutical Chemistry Laboratory (BCH) - Core services (3) and Instruments (6)

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Boros E, Packard AB. Radioactive Transition Metals for Imaging and Therapy. Chem Rev. 2018 Oct 09. PMID: 30299088.
    Citations:    Fields:    
  2. Moskowitzova K, Shin B, Liu K, Ramirez-Barbieri G, Guariento A, Blitzer D, Thedsanamoorthy JK, Yao R, Snay ER, Inkster JAH, Orfany A, Zurakowski D, Cowan DB, Packard AB, Visner GA, Del Nido PJ, McCully JD. Mitochondrial transplantation prolongs cold ischemia time in murine heart transplantation. J Heart Lung Transplant. 2019 Jan; 38(1):92-99. PMID: 30391192.
    Citations:    Fields:    
  3. Inkster JAH, Zhang S, Akurathi V, Belanger A, Dubey S, Treves T, Packard AB. New chemical and radiochemical routes to [18F]Rho6G-DEG-F, a delocalized lipophilic cation for myocardial perfusion imaging with PET. Medchemcomm. 2017 Oct 01; 8(10):1891-1896. PMID: 29276578.
    Citations:    
  4. Dearling JLJ, Packard AB. Molecular imaging in nanomedicine - A developmental tool and a clinical necessity. J Control Release. 2017 09 10; 261:23-30. PMID: 28624600.
    Citations: 1     Fields:    Translation:HumansAnimals
  5. Subramaniam RM, Jadvar H, Colletti PM, Guimaraes A, Gullapali R, Iagaru AH, McConathy J, Meltzer CC, Nadel H, Noto RB, Packard AB, Rohren EM, Oates ME. ACR and SNMMI Joint Credentialing Statement for PET/MRI of the Body. J Nucl Med. 2017 07; 58(7):1174-1176. PMID: 28473601.
    Citations:    Fields:    Translation:Humans
  6. Dearling JLJ, Packard AB. A Sensitive Method for the Measurement of Copper at Trace Levels Using an HPLC-Based Assay. Curr Radiopharm. 2017; 10(1):59-64. PMID: 28124595.
    Citations:    Fields:    Translation:Cells
  7. Cowan DB, Yao R, Akurathi V, Snay ER, Thedsanamoorthy JK, Zurakowski D, Ericsson M, Friehs I, Wu Y, Levitsky S, Del Nido PJ, Packard AB, McCully JD. Intracoronary Delivery of Mitochondria to the Ischemic Heart for Cardioprotection. PLoS One. 2016; 11(8):e0160889. PMID: 27500955; PMCID: PMC4976938.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  8. Dearling JL, Daka A, Veiga N, Peer D, Packard AB. Colitis ImmunoPET: Defining Target Cell Populations and Optimizing Pharmacokinetics. Inflamm Bowel Dis. 2016 Mar; 22(3):529-38. PMID: 26841223.
    Citations: 2     Fields:    Translation:Animals
  9. Kronauge J, Packard AB. In Memoriam: Alan Davison, PhD, 1936-2015. J Nucl Med. 2016 Feb; 57(2):11N-5N. PMID: 26833907.
    Citations:    Fields:    
  10. Pandey MK, Bansal A, Engelbrecht HP, Byrne JF, Packard AB, DeGrado TR. Improved production and processing of 8?Zr using a solution target. Nucl Med Biol. 2016 Jan; 43(1):97-100. PMID: 26471714.
    Citations: 1     Fields:    
  11. Daly KP, Dearling JL, Seto T, Dunning P, Fahey F, Packard AB, Briscoe DM. Use of [18F]FDG Positron Emission Tomography to Monitor the Development of Cardiac Allograft Rejection. Transplantation. 2015 Sep; 99(9):e132-9. PMID: 25675207; PMCID: PMC4532643.
    Citations: 5     Fields:    Translation:Animals
  12. Bartholomä MD, Zhang S, Akurathi V, Pacak CA, Dunning P, Fahey FH, Cowan DB, Treves ST, Packard AB. (18)F-labeled rhodamines as potential myocardial perfusion agents: comparison of pharmacokinetic properties of several rhodamines. Nucl Med Biol. 2015 Oct; 42(10):796-803. PMID: 26205075; PMCID: PMC4567415.
    Citations: 3     Fields:    Translation:AnimalsCells
  13. Dearling JL, Paterson BM, Akurathi V, Betanzos-Lara S, Treves ST, Voss SD, White JM, Huston JS, Smith SV, Donnelly PS, Packard AB. The ionic charge of copper-64 complexes conjugated to an engineered antibody affects biodistribution. Bioconjug Chem. 2015 Apr 15; 26(4):707-17. PMID: 25719414.
    Citations: 4     Fields:    Translation:AnimalsCells
  14. Jadvar H, Subramaniam RM, Berman CG, Boada F, Colletti PM, Guimaraes AR, McConathy J, Meltzer CC, Noto RB, Packard AB, Rohren EM, Oates ME. American College of Radiology and Society of Nuclear Medicine and Molecular Imaging Joint Credentialing Statement for PET/MR Imaging: Brain. J Nucl Med. 2015 Apr; 56(4):642-5. PMID: 25745088; PMCID: PMC4465538.
    Citations: 4     Fields:    Translation:Humans
  15. Sromek AW, Zhang S, Akurathi V, Packard AB, Li W, Alagille D, Morley TJ, Baldwin R, Tamagnan G, Neumeyer JL. Convenient synthesis of 18F-radiolabeled R-(-)-N-n-propyl-2-(3-fluoropropanoxy-11-hydroxynoraporphine. J Labelled Comp Radiopharm. 2014 Dec; 57(14):725-9. PMID: 25400260; PMCID: PMC4275395.
    Citations: 1     Fields:    
  16. DeGrado TR, Pandey MK, Byrne JF, Engelbrecht HP, Jiang H, Packard AB, Thomas KA, Jacobson MS, Curran GL, Lowe VJ. Preparation and preliminary evaluation of 63Zn-zinc citrate as a novel PET imaging biomarker for zinc. J Nucl Med. 2014 Aug; 55(8):1348-54. PMID: 25047329.
    Citations: 3     Fields:    Translation:HumansAnimals
  17. Pandey MK, Byrne JF, Jiang H, Packard AB, DeGrado TR. Cyclotron production of (68)Ga via the (68)Zn(p,n)(68)Ga reaction in aqueous solution. Am J Nucl Med Mol Imaging. 2014; 4(4):303-10. PMID: 24982816; PMCID: PMC4074496.
    Citations: 1     
  18. Pandey MK, Engelbrecht HP, Byrne JP, Packard AB, DeGrado TR. Production of 89Zr via the 89Y(p,n)89Zr reaction in aqueous solution: effect of solution composition on in-target chemistry. Nucl Med Biol. 2014 Apr; 41(4):309-16. PMID: 24607433.
    Citations: 3     Fields:    
  19. Dearling JL, Packard AB. On the destiny of (copper) species. J Nucl Med. 2014 Jan; 55(1):7-8. PMID: 24337607.
    Citations: 2     Fields:    Translation:HumansAnimals
  20. O'Neill AF, Dearling JL, Wang Y, Tupper T, Sun Y, Aster JC, Calicchio ML, Perez-Atayde AR, Packard AB, Kung AL. Targeted imaging of Ewing sarcoma in preclinical models using a 64Cu-labeled anti-CD99 antibody. Clin Cancer Res. 2014 Feb 01; 20(3):678-87. PMID: 24218512; PMCID: PMC3946397.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  21. Bartholomä MD, He H, Pacak CA, Dunning P, Fahey FH, McGowan FX, Cowan DB, Treves ST, Packard AB. Biological characterization of F-18-labeled rhodamine B, a potential positron emission tomography perfusion tracer. Nucl Med Biol. 2013 Nov; 40(8):1043-8. PMID: 24011396; PMCID: PMC3820364.
    Citations: 2     Fields:    Translation:AnimalsCells
  22. Dearling JL, Barnes JW, Panigrahy D, Zimmerman RE, Fahey F, Treves ST, Morrison MS, Kieran MW, Packard AB. Specific uptake of 99mTc-NC100692, an avß3-targeted imaging probe, in subcutaneous and orthotopic tumors. Nucl Med Biol. 2013 Aug; 40(6):788-94. PMID: 23701702.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  23. Schwarz S, Norenberg J, Berridge M, Dragotakes S, Hung J, Link J, Mason NS, Mattmuller S, Nickel RA, Packard A, Paolino J, Petry N, Ponto J, Quinton TM, Seifert KL, Swanson D, Weiner RE, Zigler S. The future of USP monographs for PET drugs. J Nucl Med. 2013 Mar; 54(3):472-5. PMID: 23264689.
    Citations: 1     Fields:    Translation:Humans
  24. Bartholomä MD, Gottumukkala V, Zhang S, Baker A, Dunning P, Fahey FH, Treves ST, Packard AB. Effect of the prosthetic group on the pharmacologic properties of 18F-labeled rhodamine B, a potential myocardial perfusion agent for positron emission tomography (PET). J Med Chem. 2012 Dec 27; 55(24):11004-12. PMID: 23210516; PMCID: PMC3544362.
    Citations: 4     Fields:    Translation:HumansAnimals
  25. Vavere AL, Butch ER, Dearling JL, Packard AB, Navid F, Shulkin BL, Barfield RC, Snyder SE. 64Cu-p-NH2-Bn-DOTA-hu14.18K322A, a PET radiotracer targeting neuroblastoma and melanoma. J Nucl Med. 2012 Nov; 53(11):1772-8. PMID: 23064212.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  26. Dearling JL, Packard AB. PET-radioimmunodetection of integrins: imaging acute colitis using a 64Cu-labeled anti-ß7 integrin antibody. Methods Mol Biol. 2012; 757:487-96. PMID: 21909929.
    Citations:    Fields:    Translation:Animals
  27. Rajkumar V, Dearling JL, Packard A, Pedley RB. Radioimmunotherapy: optimizing delivery to solid tumors. Ther Deliv. 2011 May; 2(5):567-72. PMID: 22833974.
    Citations: 2     Fields:    Translation:Humans
  28. Dearling JL, Voss SD, Dunning P, Snay E, Fahey F, Smith SV, Huston JS, Meares CF, Treves ST, Packard AB. Imaging cancer using PET--the effect of the bifunctional chelator on the biodistribution of a (64)Cu-labeled antibody. Nucl Med Biol. 2011 Jan; 38(1):29-38. PMID: 21220127; PMCID: PMC3032412.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  29. Dearling JL, Park EJ, Dunning P, Baker A, Fahey F, Treves ST, Soriano SG, Shimaoka M, Packard AB, Peer D. Detection of intestinal inflammation by MicroPET imaging using a (64)Cu-labeled anti-beta(7) integrin antibody. Inflamm Bowel Dis. 2010 Sep; 16(9):1458-66. PMID: 20186943.
    Citations: 4     Fields:    Translation:Animals
  30. Gottumukkala V, Heinrich TK, Baker A, Dunning P, Fahey FH, Treves ST, Packard AB. Biodistribution and stability studies of [18F]fluoroethylrhodamine B, a potential PET myocardial perfusion agent. Nucl Med Biol. 2010 Apr; 37(3):365-70. PMID: 20346876; PMCID: PMC2847581.
    Citations: 9     Fields:    Translation:HumansAnimals
  31. Dearling JL, Packard AB. Some thoughts on the mechanism of cellular trapping of Cu(II)-ATSM. Nucl Med Biol. 2010 Apr; 37(3):237-43. PMID: 20346863.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  32. Heinrich TK, Gottumukkala V, Snay E, Dunning P, Fahey FH, Ted Treves S, Packard AB. Synthesis of fluorine-18 labeled rhodamine B: A potential PET myocardial perfusion imaging agent. Appl Radiat Isot. 2010 Jan; 68(1):96-100. PMID: 19783150; PMCID: PMC2787817.
    Citations: 8     Fields:    Translation:Animals
  33. Kiani S, Staples RJ, Treves ST, Packard AB. Synthesis and Characterization of a Tetramethyl Furanone Functionalized Diiminedioxime, A Potential Ligand for Cu Radiopharmaceuticals, and its Copper(II) and Nickel(II) Complexes. Polyhedron. 2009 Mar 12; 28(4):775-781. PMID: 20161333.
    Citations: 1     
  34. Grant FD, Fahey FH, Packard AB, Davis RT, Alavi A, Treves ST. Skeletal PET with 18F-fluoride: applying new technology to an old tracer. J Nucl Med. 2008 Jan; 49(1):68-78. PMID: 18077529.
    Citations: 109     Fields:    Translation:Humans
  35. Voss SD, Smith SV, DiBartolo N, McIntosh LJ, Cyr EM, Bonab AA, Dearling JL, Carter EA, Fischman AJ, Treves ST, Gillies SD, Sargeson AM, Huston JS, Packard AB. Positron emission tomography (PET) imaging of neuroblastoma and melanoma with 64Cu-SarAr immunoconjugates. Proc Natl Acad Sci U S A. 2007 Oct 30; 104(44):17489-93. PMID: 17954911; PMCID: PMC2077283.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  36. Mulkern RV, Hung YP, Ababneh Z, Maier SE, Packard AB, Uluer MC, Kacher DF, Gambarota G, Voss S. On the strong field dependence and nonlinear response to gadolinium contrast agent of proton transverse relaxation rates in dairy cream. Magn Reson Imaging. 2005 Jul; 23(6):757-64. PMID: 16198831.
    Citations: 1     Fields:    
  37. Mulkern RV, Huang J, Vajapeyam S, Packard AB, Oshio K, Grinspoon S. Fat fractions and spectral T2 values in vertebral bone marrow in HIV- and non-HIV-infected men: a 1H spectroscopic imaging study. Magn Reson Med. 2004 Sep; 52(3):552-8. PMID: 15334574.
    Citations: 7     Fields:    Translation:Humans
  38. Treves ST, Packard AB, Fung LC. Assessment of rapid changes in renal blood flow with (191m)Ir, an ultra-short-lived radionuclide. J Nucl Med. 2004 Mar; 45(3):508-11. PMID: 15001695.
    Citations:    Fields:    Translation:Animals
  39. Kiani S, Staples RJ, Packard AB. A lariat-functionalized copper(II) diimine-dioxime complex. Acta Crystallogr C. 2002 Dec; 58(Pt 12):m593-5. PMID: 12466608; PMCID: PMC3544364.
    Citations:    Fields:    Translation:Cells
  40. Packard AB, Kronauge JF, Barbarics E, Kiani S, Treves ST. Synthesis and biodistribution of a Lipophilic 64Cu-labeled monocationic Copper(II) complex. Nucl Med Biol. 2002 Apr; 29(3):289-94. PMID: 11929697.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  41. Inouye H, Nguyen JT, Fraser PE, Shinchuk LM, Packard AB, Kirschner DA. Histidine residues underlie Congo red binding to A beta analogs. Amyloid. 2000 Sep; 7(3):179-88. PMID: 11019858.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  42. Treves ST, Fung L, Packard AB. Rapid renal single-photon emission tomography by continuous infusion of iridium-191m. Eur J Nucl Med. 1999 May; 26(5):489-93. PMID: 10382092.
    Citations:    Fields:    Translation:Animals
  43. Packard AB, Kronauge JF, Day PJ, Treves ST. Synthesis and biodistribution of 64Cu-labeled monocationic diiminedioxime copper(II) complexes. Nucl Med Biol. 1998 Aug; 25(6):531-7. PMID: 9751419.
    Citations: 1     Fields:    Translation:AnimalsCells
  44. Packard AB, Barbarics E, Kronauge JF, Wen PY, Day PJ, Jones AG. Comparison of uptake of 99mTc-alkylisonitriles in the rat 9L gliosarcoma tumor model. Nucl Med Biol. 1997 Jan; 24(1):21-5. PMID: 9080471.
    Citations: 1     Fields:    Translation:AnimalsCells
  45. Packard AB, Roach PJ, Davis RT, Carmant L, Davis R, Riviello J, Holmes G, Barnes PD, O'Tuama LA, Bjornson B, Treves ST. Ictal and interictal technetium-99m-bicisate brain SPECT in children with refractory epilepsy. J Nucl Med. 1996 Jul; 37(7):1101-6. PMID: 8965177.
    Citations: 2     Fields:    Translation:Humans
  46. Packard AB, Day PJ, Treves ST. An improved 191Os/191mIr generator using a hybrid anion exchanger. Nucl Med Biol. 1995 Oct; 22(7):887-91. PMID: 8547886.
    Citations:    Fields:    
  47. Packard AB, Kronauge JF, Limpa-Amara N, Lampson L, O'Tuama LA, Jones AG. Tumor uptake of 99mTc-MIBI and 201Tl by a 9L gliosarcoma brain tumor model in rats. Nucl Med Biol. 1993 Aug; 20(6):773-6. PMID: 8401378.
    Citations:    Fields:    Translation:Animals
  48. O'Tuama LA, Treves ST, Larar JN, Packard AB, Kwan AJ, Barnes PD, Scott RM, Black PM, Madsen JR, Goumnerova LC, et al. Thallium-201 versus technetium-99m-MIBI SPECT in evaluation of childhood brain tumors: a within-subject comparison. J Nucl Med. 1993 Jul; 34(7):1045-51. PMID: 8315477.
    Citations: 13     Fields:    Translation:Humans
  49. Packard AB, Lambert C. Evaluation of osmium(II)-nitrosyl complexes as a method to increase the yield of the 191Os-191mIr generator. Int J Rad Appl Instrum B. 1992 Apr; 19(3):357-62. PMID: 1629025.
    Citations:    Fields:    Translation:Cells
  50. O'Tuama LA, Packard AB, Treves ST. SPECT imaging of pediatric brain tumor with hexakis (methoxyisobutylisonitrile) technetium (I). J Nucl Med. 1990 Dec; 31(12):2040-1. PMID: 2148347.
    Citations: 13     Fields:    Translation:Humans
  51. Packard AB, Srivastava SC, Richards P, Meinken GE, Ford L, Benson WR. Synthesis and biological properties of the lipophilic technetium-99m complex 99mTc(acac)3. Int J Rad Appl Instrum B. 1989; 16(3):291-4. PMID: 2715015.
    Citations:    Fields:    Translation:Animals
  52. Packard AB, Treves ST, O'Brien GM, Lim KS. An osmium-191/iridium-191m radionuclide generator using an oxalato osmate parent complex. J Nucl Med. 1987 Oct; 28(10):1571-6. PMID: 3655910.
    Citations: 2     Fields:    
  53. Summerville DA, Packard AB, Bartynski B, Lim KS, Chervu LR, Treves ST. Evaluation of the renal clearance of technetium-99m PAHIDA in dogs. J Nucl Med. 1987 May; 28(5):907-9. PMID: 3553465.
    Citations:    Fields:    Translation:Animals
  54. Heller GV, Treves ST, Parker JA, Duke LA, O'Brien GM, Davis RT, Fitzgibbon C, Packard AB. Comparison of ultrashort-lived iridium-191m with technetium-99m for first pass radionuclide angiocardiographic evaluation of right and left ventricular function in adults. J Am Coll Cardiol. 1986 Jun; 7(6):1295-302. PMID: 3711486.
    Citations: 5     Fields:    Translation:Humans
  55. Packard AB, O'Brien GM, Treves S. The development of an 191Os----191mIr generator using an osmium chelate parent complex--I. Trans-dioxobismalonatoosmate(VI). Int J Rad Appl Instrum B. 1986; 13(5):519-22. PMID: 3818315.
    Citations: 1     Fields:    Translation:Animals
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Packard's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (247)
Explore
_
Co-Authors (41)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Physical Neighbors
_
Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.