Harvard Catalyst Profiles

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Allen Caruthers Steere, M.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01AI144365 (STEERE, ALLEN C) Jan 8, 2019 - Dec 31, 2023
    NIH/NIAID
    Cellular and humoral immunity in Lyme arthritis
    Role: Principal Investigator
  2. R01AI101175 (STEERE, ALLEN C) Jun 1, 2013 - May 31, 2017
    NIH/NIAID
    Borrelia burgdorferi-Induced Autoimmunity in Lyme Disease
    Role: Principal Investigator
  3. R56AI101175 (STEERE, ALLEN C) Sep 24, 2012 - May 31, 2013
    NIH/NIAID
    Autoimmunity to ECGF in Lyme disease and its post-infectious syndromes
    Role: Principal Investigator
  4. U01CI000157 (STEERE, ALLEN C) Apr 1, 2004 - Mar 31, 2008
    CDC/NCPDCID
    Diagnosis and Pathogenesis of Early Lyme Disease
    Role: Principal Investigator
  5. P41RR010888 (COSTELLO, CATHERINE E.) Jul 1, 1996 - Aug 9, 2012
    NIH/NCRR
    MASS SPECTROMETRY RESOURCE FOR BIOLOGY AND MEDICINE
    Role: Co-Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Steere AC. Posttreatment Lyme disease syndromes: distinct pathogenesis caused by maladaptive host responses. J Clin Invest. 2020 May 01; 130(5):2148-2151. PMID: 32281948.
    Citations:    
  2. Steere AC. Treatment of Lyme Arthritis. J Rheumatol. 2019 08; 46(8):871-873. PMID: 31371661.
    Citations:    
  3. Jutras BL, Lochhead RB, Kloos ZA, Biboy J, Strle K, Booth CJ, Govers SK, Gray J, Schumann P, Vollmer W, Bockenstedt LK, Steere AC, Jacobs-Wagner C. Borrelia burgdorferi peptidoglycan is a persistent antigen in patients with Lyme arthritis. Proc Natl Acad Sci U S A. 2019 07 02; 116(27):13498-13507. PMID: 31209025.
    Citations:    
  4. Reinink P, Souter MNT, Cheng TY, van Gorkom T, Lenz S, Kubler-Kielb J, Strle K, Kremer K, Thijsen SFT, Steere AC, Godfrey DI, Pellicci DG, Moody DB, Van Rhijn I. CD1b presents self and Borrelia burgdorferi diacylglycerols to human T cells. Eur J Immunol. 2019 05; 49(5):737-746. PMID: 30854633.
    Citations:    
  5. Schutzer SE, Body BA, Boyle J, Branson BM, Dattwyler RJ, Fikrig E, Gerald NJ, Gomes-Solecki M, Kintrup M, Ledizet M, Levin AE, Lewinski M, Liotta LA, Marques A, Mead PS, Mongodin EF, Pillai S, Rao P, Robinson WH, Roth KM, Schriefer ME, Slezak T, Snyder JL, Steere AC, Witkowski J, Wong SJ, Branda JA. Direct Diagnostic Tests for Lyme Disease. Clin Infect Dis. 2019 03 05; 68(6):1052-1057. PMID: 30307486.
    Citations:    Fields:    
  6. Lochhead RB, Ordoñez D, Arvikar SL, Aversa JM, Oh LS, Heyworth B, Sadreyev R, Steere AC, Strle K. Interferon-gamma production in Lyme arthritis synovial tissue promotes differentiation of fibroblast-like synoviocytes into immune effector cells. Cell Microbiol. 2019 02; 21(2):e12992. PMID: 30550623.
    Citations:    Fields:    
  7. Lochhead RB, Arvikar SL, Aversa JM, Sadreyev RI, Strle K, Steere AC. Robust interferon signature and suppressed tissue repair gene expression in synovial tissue from patients with postinfectious, Borrelia burgdorferi-induced Lyme arthritis. Cell Microbiol. 2019 02; 21(2):e12954. PMID: 30218476.
    Citations:    Fields:    
  8. Sulka KB, Strle K, Crowley JT, Lochhead RB, Anthony R, Steere AC. Correlation of Lyme Disease-Associated IgG4 Autoantibodies With Synovial Pathology in Antibiotic-Refractory Lyme Arthritis. Arthritis Rheumatol. 2018 11; 70(11):1835-1846. PMID: 29790305.
    Citations:    Fields:    
  9. Branda JA, Body BA, Boyle J, Branson BM, Dattwyler RJ, Fikrig E, Gerald NJ, Gomes-Solecki M, Kintrup M, Ledizet M, Levin AE, Lewinski M, Liotta LA, Marques A, Mead PS, Mongodin EF, Pillai S, Rao P, Robinson WH, Roth KM, Schriefer ME, Slezak T, Snyder J, Steere AC, Witkowski J, Wong SJ, Schutzer SE. Advances in Serodiagnostic Testing for Lyme Disease Are at Hand. Clin Infect Dis. 2018 03 19; 66(7):1133-1139. PMID: 29228208.
    Citations: 2     Fields:    
  10. Branda JA, Steere AC. Reply to Naktin. Clin Infect Dis. 2017 11 29; 65(12):2157-2158. PMID: 28605417.
    Citations:    Fields:    
  11. Steere AC, Franc S, Wormser GP, Hu LT, Branda JA, Hovius JWR, Li X, Mead PS. Correction: Lyme borreliosis. Nat Rev Dis Primers. 2017 Aug 03; 3:17062. PMID: 28770818.
    Citations:    Fields:    
  12. Pianta A, Arvikar SL, Strle K, Drouin EE, Wang Q, Costello CE, Steere AC. Two rheumatoid arthritis-specific autoantigens correlate microbial immunity with autoimmune responses in joints. J Clin Invest. 2017 Aug 01; 127(8):2946-2956. PMID: 28650341.
    Citations: 9     Fields:    Translation:HumansCells
  13. Lochhead RB, Strle K, Kim ND, Kohler MJ, Arvikar SL, Aversa JM, Steere AC. MicroRNA Expression Shows Inflammatory Dysregulation and Tumor-Like Proliferative Responses in Joints of Patients With Postinfectious Lyme Arthritis. Arthritis Rheumatol. 2017 05; 69(5):1100-1110. PMID: 28076897.
    Citations: 2     Fields:    Translation:Humans
  14. Branda JA, Strle K, Nigrovic LE, Lantos PM, Lepore TJ, Damle NS, Ferraro MJ, Steere AC. Evaluation of Modified 2-Tiered Serodiagnostic Testing Algorithms for Early Lyme Disease. Clin Infect Dis. 2017 04 15; 64(8):1074-1080. PMID: 28329259.
    Citations: 5     Fields:    Translation:Humans
  15. Pianta A, Arvikar S, Strle K, Drouin EE, Wang Q, Costello CE, Steere AC. Evidence of the Immune Relevance of Prevotella copri, a Gut Microbe, in Patients With Rheumatoid Arthritis. Arthritis Rheumatol. 2017 05; 69(5):964-975. PMID: 27863183.
    Citations: 11     Fields:    Translation:HumansCells
  16. Strle K, Sulka KB, Pianta A, Crowley JT, Arvikar SL, Anselmo A, Sadreyev R, Steere AC. T-Helper 17 Cell Cytokine Responses in Lyme Disease Correlate With Borrelia burgdorferi Antibodies During Early Infection and With Autoantibodies Late in the Illness in Patients With Antibiotic-Refractory Lyme Arthritis. Clin Infect Dis. 2017 Apr 01; 64(7):930-938. PMID: 28077518.
    Citations: 3     Fields:    Translation:HumansCells
  17. Glatz M, Means T, Haas J, Steere AC, Müllegger RR. Characterization of the early local immune response to Ixodes ricinus tick bites in human skin. Exp Dermatol. 2017 03; 26(3):263-269. PMID: 27623398.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  18. Arvikar SL, Steere AC. Reply. Arthritis Rheumatol. 2017 03; 69(3):684-685. PMID: 27863140.
    Citations:    Fields:    
  19. Arvikar SL, Crowley JT, Sulka KB, Steere AC. Autoimmune Arthritides, Rheumatoid Arthritis, Psoriatic Arthritis, or Peripheral Spondyloarthritis Following Lyme Disease. Arthritis Rheumatol. 2017 01; 69(1):194-202. PMID: 27636905.
    Citations: 5     Fields:    Translation:Humans
  20. Steere AC, Strle F, Wormser GP, Hu LT, Branda JA, Hovius JW, Li X, Mead PS. Lyme borreliosis. Nat Rev Dis Primers. 2016 12 15; 2:16090. PMID: 27976670.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  21. Wang Q, Drouin EE, Yao C, Zhang J, Huang Y, Leon DR, Steere AC, Costello CE. Immunogenic HLA-DR-Presented Self-Peptides Identified Directly from Clinical Samples of Synovial Tissue, Synovial Fluid, or Peripheral Blood in Patients with Rheumatoid Arthritis or Lyme Arthritis. J Proteome Res. 2017 01 06; 16(1):122-136. PMID: 27726376.
    Citations: 5     Fields:    Translation:HumansCells
  22. Cerar T, Strle F, Stupica D, Ruzic-Sabljic E, McHugh G, Steere AC, Strle K. Differences in Genotype, Clinical Features, and Inflammatory Potential of Borrelia burgdorferi sensu stricto Strains from Europe and the United States. Emerg Infect Dis. 2016 May; 22(5):818-27. PMID: 27088349.
    Citations: 12     Fields:    Translation:HumansCells
  23. Crowley JT, Strle K, Drouin EE, Pianta A, Arvikar SL, Wang Q, Costello CE, Steere AC. Matrix metalloproteinase-10 is a target of T and B cell responses that correlate with synovial pathology in patients with antibiotic-refractory Lyme arthritis. J Autoimmun. 2016 May; 69:24-37. PMID: 26922382.
    Citations: 9     Fields:    Translation:HumansCells
  24. Lahey LJ, Panas MW, Mao R, Delanoy M, Flanagan JJ, Binder SR, Rebman AW, Montoya JG, Soloski MJ, Steere AC, Dattwyler RJ, Arnaboldi PM, Aucott JN, Robinson WH. Development of a Multiantigen Panel for Improved Detection of Borrelia burgdorferi Infection in Early Lyme Disease. J Clin Microbiol. 2015 Dec; 53(12):3834-41. PMID: 26447113.
    Citations: 7     Fields:    Translation:HumansCells
  25. Pianta A, Drouin EE, Crowley JT, Arvikar S, Strle K, Costello CE, Steere AC. Annexin A2 is a target of autoimmune T and B cell responses associated with synovial fibroblast proliferation in patients with antibiotic-refractory Lyme arthritis. Clin Immunol. 2015 Oct; 160(2):336-41. PMID: 26187145.
    Citations: 11     Fields:    Translation:HumansCells
  26. Arvikar SL, Steere AC. Diagnosis and treatment of Lyme arthritis. Infect Dis Clin North Am. 2015 Jun; 29(2):269-80. PMID: 25999223.
    Citations: 19     Fields:    Translation:HumansCells
  27. Crowley JT, Drouin EE, Pianta A, Strle K, Wang Q, Costello CE, Steere AC. A Highly Expressed Human Protein, Apolipoprotein B-100, Serves as an Autoantigen in a Subgroup of Patients With Lyme Disease. J Infect Dis. 2015 Dec 01; 212(11):1841-50. PMID: 26014802.
    Citations: 13     Fields:    Translation:HumansCells
  28. Steere AC, Arvikar SL. Editorial commentary: what constitutes appropriate treatment of post-Lyme disease symptoms and other pain and fatigue syndromes? Clin Infect Dis. 2015 Jun 15; 60(12):1783-5. PMID: 25852123.
    Citations: 2     Fields:    Translation:Humans
  29. Londoño D, Cadavid D, Drouin EE, Strle K, McHugh G, Aversa JM, Steere AC. Antibodies to endothelial cell growth factor and obliterative microvascular lesions in the synovium of patients with antibiotic-refractory lyme arthritis. Arthritis Rheumatol. 2014 Aug; 66(8):2124-33. PMID: 24623727.
    Citations: 10     Fields:    Translation:Humans
  30. Strle K, Stupica D, Drouin EE, Steere AC, Strle F. Reply to Seligman et Al. Clin Infect Dis. 2014 Sep 01; 59(5):747-8. PMID: 24812297.
    Citations:    Fields:    Translation:Humans
  31. Strle K, Stupica D, Drouin EE, Steere AC, Strle F. Reply to Parvu and Parvu. Clin Infect Dis. 2014 Apr; 58(8):1200. PMID: 24470277.
    Citations:    Fields:    Translation:Humans
  32. Strle K, Stupica D, Drouin EE, Steere AC, Strle F. Elevated levels of IL-23 in a subset of patients with post-lyme disease symptoms following erythema migrans. Clin Infect Dis. 2014 Feb; 58(3):372-80. PMID: 24218102.
    Citations: 16     Fields:    Translation:HumansCells
  33. Katchar K, Drouin EE, Steere AC. Natural killer cells and natural killer T cells in Lyme arthritis. Arthritis Res Ther. 2013 Nov 07; 15(6):R183. PMID: 24286535.
    Citations: 8     Fields:    Translation:HumansCells
  34. Li X, Strle K, Wang P, Acosta DI, McHugh GA, Sikand N, Strle F, Steere AC. Tick-specific borrelial antigens appear to be upregulated in American but not European patients with Lyme arthritis, a late manifestation of Lyme borreliosis. J Infect Dis. 2013 Sep; 208(6):934-41. PMID: 23766526.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  35. Vudattu NK, Strle K, Steere AC, Drouin EE. Dysregulation of CD4+CD25(high) T cells in the synovial fluid of patients with antibiotic-refractory Lyme arthritis. Arthritis Rheum. 2013 Jun; 65(6):1643-53. PMID: 23450683.
    Citations: 16     Fields:    Translation:HumansCells
  36. Branda JA, Strle F, Strle K, Sikand N, Ferraro MJ, Steere AC. Performance of United States serologic assays in the diagnosis of Lyme borreliosis acquired in Europe. Clin Infect Dis. 2013 Aug; 57(3):333-40. PMID: 23592827.
    Citations: 23     Fields:    Translation:Humans
  37. Steere AC. Reinfection versus relapse in Lyme disease. N Engl J Med. 2013 03 14; 368(11):1064. PMID: 23495391.
    Citations:    Fields:    Translation:HumansCells
  38. Drouin EE, Seward RJ, Strle K, McHugh G, Katchar K, Londoño D, Yao C, Costello CE, Steere AC. A novel human autoantigen, endothelial cell growth factor, is a target of T and B cell responses in patients with Lyme disease. Arthritis Rheum. 2013 Jan; 65(1):186-96. PMID: 23044924.
    Citations: 23     Fields:    Translation:HumansCells
  39. Arvikar SL, Collier DS, Fisher MC, Unizony S, Cohen GL, McHugh G, Kawai T, Strle K, Steere AC. Clinical correlations with Porphyromonas gingivalis antibody responses in patients with early rheumatoid arthritis. Arthritis Res Ther. 2013; 15(5):R109. PMID: 24017968.
    Citations: 14     Fields:    Translation:HumansCells
  40. Steere AC. Reinfection versus relapse in Lyme disease. N Engl J Med. 2012 Nov 15; 367(20):1950-1. PMID: 23150963.
    Citations: 2     Fields:    Translation:HumansCells
  41. Wormser GP, Schriefer M, Aguero-Rosenfeld ME, Levin A, Steere AC, Nadelman RB, Nowakowski J, Marques A, Johnson BJ, Dumler JS. Single-tier testing with the C6 peptide ELISA kit compared with two-tier testing for Lyme disease. Diagn Microbiol Infect Dis. 2013 Jan; 75(1):9-15. PMID: 23062467.
    Citations: 37     Fields:    Translation:Humans
  42. Strle K, Shin JJ, Glickstein LJ, Steere AC. Association of a Toll-like receptor 1 polymorphism with heightened Th1 inflammatory responses and antibiotic-refractory Lyme arthritis. Arthritis Rheum. 2012 May; 64(5):1497-507. PMID: 22246581.
    Citations: 35     Fields:    Translation:HumansCells
  43. Branda JA, Linskey K, Kim YA, Steere AC, Ferraro MJ. Two-tiered antibody testing for Lyme disease with use of 2 enzyme immunoassays, a whole-cell sonicate enzyme immunoassay followed by a VlsE C6 peptide enzyme immunoassay. Clin Infect Dis. 2011 Sep; 53(6):541-7. PMID: 21865190.
    Citations: 36     Fields:    Translation:HumansCells
  44. Auwaerter PG, Bakken JS, Dattwyler RJ, Dumler JS, Halperin JJ, McSweegan E, Nadelman RB, O'Connell S, Shapiro ED, Sood SK, Steere AC, Weinstein A, Wormser GP. Antiscience and ethical concerns associated with advocacy of Lyme disease. Lancet Infect Dis. 2011 Sep; 11(9):713-9. PMID: 21867956.
    Citations: 18     Fields:    Translation:HumansCells
  45. Li X, McHugh GA, Damle N, Sikand VK, Glickstein L, Steere AC. Burden and viability of Borrelia burgdorferi in skin and joints of patients with erythema migrans or lyme arthritis. Arthritis Rheum. 2011 Aug; 63(8):2238-47. PMID: 21590753.
    Citations: 37     Fields:    Translation:HumansCells
  46. Strle K, Jones KL, Drouin EE, Li X, Steere AC. Borrelia burgdorferi RST1 (OspC type A) genotype is associated with greater inflammation and more severe Lyme disease. Am J Pathol. 2011 Jun; 178(6):2726-39. PMID: 21641395.
    Citations: 29     Fields:    Translation:HumansCells
  47. Porwancher RB, Hagerty