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profileAlvaro Christian Laga, M.D.

TitleAssistant Professor of Pathology
InstitutionBrigham and Women's Hospital
DepartmentPathology
AddressBrigham and Womens Hospital
Suite 401
221 Longwood Ave
Boston MA 02115
Phone617/278-0178
Fax617/264-5149
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Pohthipornthawat N, Feldman S, Granter SR, Laga AC, Crum CP, Herfs M. Epidermodysplasia Verruciformis-like HPV infection of the Vulva in Immunosuppressed Women. Int J Gynecol Pathol. 2017 Jul 11. PMID: 28700430.
    View in: PubMed
  2. Gunasekera NS, Maniar LEG, Lezcano C, Laga AC, Merola JF. Intralesional Sodium Thiosulfate Treatment for Calcinosis Cutis in the Setting of Lupus Panniculitis. JAMA Dermatol. 2017 May 31. PMID: 28564698.
    View in: PubMed
  3. Laga AC, Larson A, Granter SR. Histopathologic Spectrum of Connective Tissue Diseases Commonly Affecting the Skin. Surg Pathol Clin. 2017 Jun; 10(2):477-503. PMID: 28477892.
    View in: PubMed
  4. Solomon IH, Hornick JL, Laga AC. Immunohistochemistry Is Rarely Justified for the Diagnosis of Viral Infections. Am J Clin Pathol. 2017 Jan 01; 147(1):96-104. PMID: 28007703.
    View in: PubMed
  5. Laga AC, Shroba SM, Hanna J. Atypical hand, foot and mouth disease in adults associated with coxsackievirus A6: a clinico-pathologic study. J Cutan Pathol. 2016 Nov; 43(11):940-945. PMID: 27445155.
    View in: PubMed
  6. Tan JL, Fogley RD, Flynn RA, Ablain J, Yang S, Saint-André V, Fan ZP, Do BT, Laga AC, Fujinaga K, Santoriello C, Greer CB, Kim YJ, Clohessy JG, Bothmer A, Pandell N, Avagyan S, Brogie JE, van Rooijen E, Hagedorn EJ, Shyh-Chang N, White RM, Price DH, Pandolfi PP, Peterlin BM, Zhou Y, Kim TH, Asara JM, Chang HY, Young RA, Zon LI. Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma. Mol Cell. 2016 Apr 07; 62(1):34-46. PMID: 27058786; PMCID: PMC4836061 [Available on 04/07/17].
  7. Larson AR, Laga AC, Granter SR. The spectrum of histopathologic findings in cutaneous lesions in patients with Still disease. Am J Clin Pathol. 2015 Dec; 144(6):945-51. PMID: 26573002.
    View in: PubMed
  8. Granter SR, Laga AC, Larson AR. Calciphylaxis and the persistence of medical misinformation in the era of Google. Am J Clin Pathol. 2015 Sep; 144(3):427-31. PMID: 26276773.
    View in: PubMed
  9. Nyame TT, Mattos D, Lian CG, Granter SR, Laga AC, Caterson EJ. Malignant Eccrine Spiradenoma of the Face. J Craniofac Surg. 2015 Jul; 26(5):1711-2. PMID: 26167988.
    View in: PubMed
  10. Lee JJ, Sholl LM, Lindeman NI, Granter SR, Laga AC, Shivdasani P, Chin G, Luke JJ, Ott PA, Hodi FS, Mihm MC, Lin JY, Werchniak AE, Haynes HA, Bailey N, Liu R, Murphy GF, Lian CG. Targeted next-generation sequencing reveals high frequency of mutations in epigenetic regulators across treatment-naïve patient melanomas. Clin Epigenetics. 2015; 7:59. PMID: 26221190; PMCID: PMC4517542.
  11. Larson AR, Rothschild B, Walls AC, Granter SR, Qureshi AA, Murphy GF, Laga AC. Impact of the 2009 AJCC staging guidelines for melanoma on the number of mitotic figures reported by dermatopathologists at one institution. J Cutan Pathol. 2015 Aug; 42(8):536-41. PMID: 25929156.
    View in: PubMed
  12. Yazawa EM, Geddes-Sweeney JE, Cedeno-Laurent F, Walley KC, Barthel SR, Opperman MJ, Liang J, Lin JY, Schatton T, Laga AC, Mihm MC, Qureshi AA, Widlund HR, Murphy GF, Dimitroff CJ. Melanoma Cell Galectin-1 Ligands Functionally Correlate with Malignant Potential. J Invest Dermatol. 2015 Jul; 135(7):1849-1862. PMID: 25756799; PMCID: PMC4466041.
  13. Li YY, Hanna GJ, Laga AC, Haddad RI, Lorch JH, Hammerman PS. Genomic analysis of metastatic cutaneous squamous cell carcinoma. Clin Cancer Res. 2015 Mar 15; 21(6):1447-56. PMID: 25589618; PMCID: PMC4359951.
  14. Larson AR, Cibas ES, Granter SR, Laga AC. Uncovering bias in the cytologic evaluation of cervical squamous lesions. Am J Clin Pathol. 2015 Jan; 143(1):143-8. PMID: 25511153.
    View in: PubMed
  15. Nambudiri VE, Vleugels RA, Laga AC, Goldberg LJ. Clinicopathologic lessons in distinguishing cicatricial alopecia: 7 cases of lichen planopilaris misdiagnosed as discoid lupus. J Am Acad Dermatol. 2014 Oct; 71(4):e135-8. PMID: 25219732.
    View in: PubMed
  16. Lee JJ, Granter SR, Laga AC, Saavedra AP, Zhan Q, Guo W, Xu S, Murphy GF, Lian CG. 5-Hydroxymethylcytosine expression in metastatic melanoma versus nodal nevus in sentinel lymph node biopsies. Mod Pathol. 2015 Feb; 28(2):218-29. PMID: 25081754; PMCID: PMC4312506.
  17. Laga AC, Milner DA, Granter SR. Utility of acid-fast staining for detection of mycobacteria in cutaneous granulomatous tissue reactions. Am J Clin Pathol. 2014 Apr; 141(4):584-6. PMID: 24619760.
    View in: PubMed
  18. Lian CG, Bueno EM, Granter SR, Laga AC, Saavedra AP, Lin WM, Susa JS, Zhan Q, Chandraker AK, Tullius SG, Pomahac B, Murphy GF. Biomarker evaluation of face transplant rejection: association of donor T cells with target cell injury. Mod Pathol. 2014 Jun; 27(6):788-99. PMID: 24434898.
    View in: PubMed
  19. Zhou X, Velez NF, Farsani T, Tsiaras W, Laga AC, Werchniak AE, Vleugels RA. Multiple tense bullae localized to the right breast in a woman in her seventies. JAMA Dermatol. 2013 Dec; 149(12):1427-8. PMID: 24108512.
    View in: PubMed
  20. Rodig SJ, Cheng J, Wardzala J, DoRosario A, Scanlon JJ, Laga AC, Martinez-Fernandez A, Barletta JA, Bellizzi AM, Sadasivam S, Holloway DT, Cooper DJ, Kupper TS, Wang LC, DeCaprio JA. Improved detection suggests all Merkel cell carcinomas harbor Merkel polyomavirus. J Clin Invest. 2012 Dec; 122(12):4645-53. PMID: 23114601; PMCID: PMC3533549.
  21. Laga AC, Lezcano C, Ramos C, Costa H, Chian C, Salinas C, Salomon M, del Solar M, Bravo F. Cutaneous gnathostomiasis: report of 6 cases with emphasis on histopathological demonstration of the larva. J Am Acad Dermatol. 2013 Feb; 68(2):301-5. PMID: 22940406.
    View in: PubMed
  22. Velez NF, Ishizawar RC, Dellaripa PF, Saavedra AP, Laga AC, Murphy GF, Fisher DC, Kupper TS, Vleugels RA. Full facial edema: a novel presentation of subcutaneous panniculitis-like T-cell lymphoma. J Clin Oncol. 2012 Sep 01; 30(25):e233-6. PMID: 22826278.
    View in: PubMed
  23. Girouard SD, Laga AC, Mihm MC, Scolyer RA, Thompson JF, Zhan Q, Widlund HR, Lee CW, Murphy GF. SOX2 contributes to melanoma cell invasion. Lab Invest. 2012 Mar; 92(3):362-70. PMID: 22184093; PMCID: PMC3887365.
  24. Laga AC, Zhan Q, Weishaupt C, Ma J, Frank MH, Murphy GF. SOX2 and nestin expression in human melanoma: an immunohistochemical and experimental study. Exp Dermatol. 2011 Apr; 20(4):339-45. PMID: 21410764; PMCID: PMC3439836.
  25. Laga AC, Murphy GF. Cellular heterogeneity in vertical growth phase melanoma. Arch Pathol Lab Med. 2010 Dec; 134(12):1750-7. PMID: 21128771.
    View in: PubMed
  26. Laga AC, Vleugels RA, Qureshi AA, Velazquez EF. Histopathologic spectrum of psoriasiform skin reactions associated with tumor necrosis factor-a inhibitor therapy. A study of 16 biopsies. Am J Dermatopathol. 2010 Aug; 32(6):568-73. PMID: 20520526.
    View in: PubMed
  27. Lu SX, Holland AM, Na IK, Terwey TH, Alpdogan O, Bautista JL, Smith OM, Suh D, King C, Kochman A, Hubbard VM, Rao UK, Yim N, Liu C, Laga AC, Murphy G, Jenq RR, Zakrzewski JL, Penack O, Dykstra L, Bampoe K, Perez L, Furie B, Furie B, van den Brink MR. Absence of P-selectin in recipients of allogeneic bone marrow transplantation ameliorates experimental graft-versus-host disease. J Immunol. 2010 Aug 01; 185(3):1912-9. PMID: 20622117; PMCID: PMC3752704.
  28. Laga AC, Lai CY, Zhan Q, Huang SJ, Velazquez EF, Yang Q, Hsu MY, Murphy GF. Expression of the embryonic stem cell transcription factor SOX2 in human skin: relevance to melanocyte and merkel cell biology. Am J Pathol. 2010 Feb; 176(2):903-13. PMID: 20042675; PMCID: PMC2808095.
  29. Laga AC, Murphy GF. The translational basis of human cutaneous photoaging: on models, methods, and meaning. Am J Pathol. 2009 Feb; 174(2):357-60. PMID: 19147830; PMCID: PMC2630545.
  30. Laga A, Kurtis J, Sweeney J. Recurrent transfusion-related acute lung injury after fresh frozen plasma in a patient with hereditary factor V deficiency. Am J Hematol. 2008 Aug; 83(8):680. PMID: 18429049.
    View in: PubMed
  31. Laga AC, Tajirian AL, Islam MN, Bhattacharyya I, Cohen DM, Plamondon CJ, Robinson-Bostom L. Myopericytoma: report of two cases associated with trauma. J Cutan Pathol. 2008 Sep; 35(9):866-70. PMID: 18494828.
    View in: PubMed
  32. Laga A, Cheves T, Maroto S, Coutts M, Sweeney J. The suitability of hemolyzed specimens for compatibility testing using automated technology. Transfusion. 2008 Aug; 48(8):1713-20. PMID: 18482191.
    View in: PubMed
  33. Laga AC, Cheves TA, Sweeney JD. The effect of specimen hemolysis on coagulation test results. Am J Clin Pathol. 2006 Nov; 126(5):748-55. PMID: 17050072.
    View in: PubMed
  34. Granville L, Laga AC, Allen TC, Dishop M, Roggli VL, Churg A, Zander DS, Cagle PT. Review and update of uncommon primary pleural tumors: a practical approach to diagnosis. Arch Pathol Lab Med. 2005 Nov; 129(11):1428-43. PMID: 16253024.
    View in: PubMed
  35. Laga AC, Zander DS, Cagle PT. Prognostic significance of cyclooxygenase 2 expression in 259 cases of non-small cell lung cancer. Arch Pathol Lab Med. 2005 Sep; 129(9):1113-7. PMID: 16119982.
    View in: PubMed
  36. Zhang H, Liu J, Cagle PT, Allen TC, Laga AC, Zander DS. Distinction of pulmonary small cell carcinoma from poorly differentiated squamous cell carcinoma: an immunohistochemical approach. Mod Pathol. 2005 Jan; 18(1):111-8. PMID: 15309021.
    View in: PubMed
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