Harvard Catalyst Profiles

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David E. Sosnovik, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL141563 (SOSNOVIK, DAVID E) Aug 1, 2018 - May 31, 2022
    NIH/NHLBI
    Imaging Histone Deacetylase in the Heart and Bone Marrow
    Role: Principal Investigator
  2. R01HL112831 (SOSNOVIK, DAVID E) Jul 15, 2013 - May 31, 2017
    NIH/NHLBI
    Cardiac MRI-Tractography In Vivo: Integrated Imaging of Structure and Function
    Role: Principal Investigator
  3. R01HL109448 (CARAVAN, PETER D) Aug 1, 2011 - May 31, 2021
    NIH/NHLBI
    PET Imaging of Thrombus
    Role: Co-Principal Investigator
  4. R01HL093038 (SOSNOVIK, DAVID E) Aug 1, 2008 - May 31, 2013
    NIH/NHLBI
    Molecular and Microstructural Imaging of Cardiomyocyte Apoptosis and Autophagy
    Role: Principal Investigator
  5. K08HL079984 (SOSNOVIK, DAVID E) Apr 15, 2005 - Feb 28, 2010
    NIH/NHLBI
    Magnetic Resonance Imaging of Cardiomyocyte Apoptosis
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Tawakol A, Sosnovik DE. Multiparametric Molecular Imaging of Atherosclerosis: Insights Into Disease Pathology and Risk. Circ Cardiovasc Imaging. 2020 Mar; 13(3):e010494. PMID: 32164452.
    Citations:    
  2. Tawakol A, Fakhri GE, Catana C, Sosnovik DE. Advances in cardiac PET/MR imaging: Facilitating cutting-edge structural and biological phenotyping of the cardiovascular system. J Nucl Cardiol. 2020 Mar 03. PMID: 32128674.
    Citations:    
  3. van den Boomen M, Manhard MK, Snel GJH, Han S, Emblem KE, Slart RHJA, Sosnovik DE, Catana C, Rosen BR, Prakken NHJ, Nguyen CT, Borra RJH, Setsompop K. Blood Oxygen Level-Dependent MRI of the Myocardium with Multiecho Gradient-Echo Spin-Echo Imaging. Radiology. 2020 Mar; 294(3):538-545. PMID: 31961241.
    Citations:    
  4. Unno K, Oikonomopoulos A, Fujikawa Y, Okuno Y, Narita S, Kato T, Hayashida R, Kondo K, Shibata R, Murohara T, Yang Y, Dangwal S, Sereti KI, Yiling Q, Johnson K, Jha A, Sosnovik DE, Fann Y, Liao R. Alteration in ventricular pressure stimulates cardiac repair and remodeling. J Mol Cell Cardiol. 2019 08; 133:174-187. PMID: 31220468.
    Citations:    
  5. Stoeck CT, Scott AD, Ferreira PF, Tunnicliffe EM, Teh I, Nielles-Vallespin S, Moulin K, Sosnovik DE, Viallon M, Croisille P, Kozerke S, Firmin DN, Ennis DB, Schneider JE. Motion-Induced Signal Loss in In Vivo Cardiac Diffusion-Weighted Imaging. J Magn Reson Imaging. 2020 Jan; 51(1):319-320. PMID: 31034705.
    Citations:    
  6. Sosnovik DE, Geva T. Imaging the Microstructure of the Human Fetal Heart. Circ Cardiovasc Imaging. 2018 10; 11(10):e008298. PMID: 30354486.
    Citations:    Fields:    
  7. Sosnovik DE, Tawakol A. Noninvasive Tissue Characterization of Post-Infarction Myocardium. JACC Cardiovasc Imaging. 2018 09; 11(9):1257-1259. PMID: 30190028.
    Citations:    Fields:    
  8. Vandoorne K, Rohde D, Kim HY, Courties G, Wojtkiewicz G, Honold L, Hoyer FF, Frodermann V, Nayar R, Herisson F, Jung Y, Désogère PA, Vinegoni C, Caravan P, Weissleder R, Sosnovik DE, Lin CP, Swirski FK, Nahrendorf M. Imaging the Vascular Bone Marrow Niche During Inflammatory Stress. Circ Res. 2018 08 03; 123(4):415-427. PMID: 29980569.
    Citations:    Fields:    
  9. Panagia M, Chen HH, Croteau D, Iris Chen YC, Ran C, Luptak I, Josephson L, Colucci WS, Sosnovik DE. Multiplexed Optical Imaging of Energy Substrates Reveals That Left Ventricular Hypertrophy Is Associated With Brown Adipose Tissue Activation. Circ Cardiovasc Imaging. 2018 03; 11(3):e007007. PMID: 29555834.
    Citations: 1     Fields:    
  10. Mekkaoui C, Jackowski MP, Kostis WJ, Stoeck CT, Thiagalingam A, Reese TG, Reddy VY, Ruskin JN, Kozerke S, Sosnovik DE. Myocardial Scar Delineation Using Diffusion Tensor Magnetic Resonance Tractography. J Am Heart Assoc. 2018 02 02; 7(3). PMID: 29420216.
    Citations: 1     Fields:    
  11. Tawakol A, Sosnovik DE. PET/MR Imaging of Atherosclerosis: Insights Into Atheroma Structure and Biology. JACC Cardiovasc Imaging. 2018 02; 11(2 Pt 2):302-304. PMID: 29413440.
    Citations:    Fields:    
  12. Hulsmans M, Sager HB, Roh JD, Valero-Muñoz M, Houstis NE, Iwamoto Y, Sun Y, Wilson RM, Wojtkiewicz G, Tricot B, Osborne MT, Hung J, Vinegoni C, Naxerova K, Sosnovik DE, Zile MR, Bradshaw AD, Liao R, Tawakol A, Weissleder R, Rosenzweig A, Swirski FK, Sam F, Nahrendorf M. Cardiac macrophages promote diastolic dysfunction. J Exp Med. 2018 02 05; 215(2):423-440. PMID: 29339450.
    Citations: 6     Fields:    
  13. Asnani A, Zheng B, Liu Y, Wang Y, Chen HH, Vohra A, Chi A, Cornella-Taracido I, Wang H, Johns DG, Sosnovik DE, Peterson RT. Highly potent visnagin derivatives inhibit Cyp1 and prevent doxorubicin cardiotoxicity. JCI Insight. 2018 01 11; 3(1). PMID: 29321375.
    Citations:    Fields:    
  14. van den Boomen M, Slart RHJA, Hulleman EV, Dierckx RAJO, Velthuis BK, van der Harst P, Sosnovik DE, Borra RJH, Prakken NHJ. Native T1 reference values for nonischemic cardiomyopathies and populations with increased cardiovascular risk: A systematic review and meta-analysis. J Magn Reson Imaging. 2018 04; 47(4):891-912. PMID: 29131444.
    Citations:    Fields:    
  15. Gale EM, Wey HY, Ramsay I, Yen YF, Sosnovik DE, Caravan P. A Manganese-based Alternative to Gadolinium: Contrast-enhanced MR Angiography, Excretion, Pharmacokinetics, and Metabolism. Radiology. 2018 03; 286(3):865-872. PMID: 29117483.
    Citations: 1     Fields:    Translation:Animals
  16. Ferrari M, Jain IH, Goldberger O, Rezoagli E, Thoonen R, Cheng KH, Sosnovik DE, Scherrer-Crosbie M, Mootha VK, Zapol WM. Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome. Proc Natl Acad Sci U S A. 2017 05 23; 114(21):E4241-E4250. PMID: 28483998.
    Citations: 5     Fields:    Translation:AnimalsCells
  17. Shea BS, Probst CK, Brazee PL, Rotile NJ, Blasi F, Weinreb PH, Black KE, Sosnovik DE, Van Cott EM, Violette SM, Caravan P, Tager AM. Uncoupling of the profibrotic and hemostatic effects of thrombin in lung fibrosis. JCI Insight. 2017 May 04; 2(9). PMID: 28469072.
    Citations: 2     Fields:    
  18. Dos Santos Ferreira D, Jesus de Oliveira Pinto BL, Kumar V, Cardoso VN, Fernandes SO, Souza CM, Cassali GD, Moore A, Sosnovik DE, Farrar CT, Leite EA, Alves RJ, de Oliveira MC, Guimarães AR, Caravan P. Evaluation of antitumor activity and cardiac toxicity of a bone-targeted ph-sensitive liposomal formulation in a bone metastasis tumor model in mice. Nanomedicine. 2017 07; 13(5):1693-1701. PMID: 28343016.
    Citations:    Fields:    Translation:Animals
  19. Chen HH, Yuan H, Cho H, Feng Y, Ngoy S, Kumar AT, Liao R, Chao W, Josephson L, Sosnovik DE. Theranostic Nucleic Acid Binding Nanoprobe Exerts Anti-inflammatory and Cytoprotective Effects in Ischemic Injury. Theranostics. 2017; 7(4):814-825. PMID: 28382156.
    Citations:    Fields:    Translation:Animals
  20. Mekkaoui C, Reese TG, Jackowski MP, Cauley SF, Setsompop K, Bhat H, Sosnovik DE. Diffusion Tractography of the Entire Left Ventricle by Using Free-breathing Accelerated Simultaneous Multisection Imaging. Radiology. 2017 03; 282(3):850-856. PMID: 27681278.
    Citations: 5     Fields:    Translation:Humans
  21. Goergen CJ, Chen HH, Sakadžic S, Srinivasan VJ, Sosnovik DE. Microstructural characterization of myocardial infarction with optical coherence tractography and two-photon microscopy. Physiol Rep. 2016 09; 4(18). PMID: 27650248.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  22. Panagia M, Chen YC, Chen HH, Ernande L, Chen C, Chao W, Kwong K, Scherrer-Crosbie M, Sosnovik DE. Functional and anatomical characterization of brown adipose tissue in heart failure with blood oxygen level dependent magnetic resonance. NMR Biomed. 2016 07; 29(7):978-84. PMID: 27226402.
    Citations: 2     Fields:    Translation:AnimalsCells
  23. Zou L, Chen HH, Li D, Xu G, Feng Y, Chen C, Wang L, Sosnovik DE, Chao W. Imaging Lymphoid Cell Death In Vivo During Polymicrobial Sepsis. Crit Care Med. 2015 Nov; 43(11):2303-12. PMID: 26335111.
    Citations: 2     Fields:    Translation:AnimalsCells
  24. Mekkaoui C, Reese TG, Jackowski MP, Bhat H, Sosnovik DE. Diffusion MRI in the heart. NMR Biomed. 2017 Mar; 30(3). PMID: 26484848.
    Citations: 9     Fields:    Translation:HumansAnimals
  25. Normandin MD, Yuan H, Wilks MQ, Chen HH, Kinsella JM, Cho H, Guehl NJ, Absi-Halabi N, Hosseini SM, El Fakhri G, Sosnovik DE, Josephson L. Heat-Induced Radiolabeling of Nanoparticles for Monocyte Tracking by PET. Angew Chem Int Ed Engl. 2015 Oct 26; 54(44):13002-6. PMID: 26368132.
    Citations: 4     Fields:    Translation:AnimalsCells
  26. Sosnovik DE. Seeing What We Build--The Need for New Imaging Techniques in Myocardial Regeneration. J Am Heart Assoc. 2015 Jul 27; 4(7). PMID: 26215973.
    Citations: 1     Fields:    Translation:Humans
  27. Thoonen R, Ernande L, Cheng J, Nagasaka Y, Yao V, Miranda-Bezerra A, Chen C, Chao W, Panagia M, Sosnovik DE, Puppala D, Armoundas AA, Hindle A, Bloch KD, Buys ES, Scherrer-Crosbie M. Functional brown adipose tissue limits cardiomyocyte injury and adverse remodeling in catecholamine-induced cardiomyopathy. J Mol Cell Cardiol. 2015 Jul; 84:202-11. PMID: 25968336.
    Citations: 8     Fields:    Translation:AnimalsCells
  28. Chen HH, Yuan H, Cho H, Sosnovik DE, Josephson L. Cytoprotective nanoparticles by conjugation of a polyhis tagged annexin V to a nanoparticle drug. Nanoscale. 2015 Feb 14; 7(6):2255-9. PMID: 25572921.
    Citations:    Fields:    Translation:HumansAnimalsCells
  29. Liu Y, Asnani A, Zou L, Bentley VL, Yu M, Wang Y, Dellaire G, Sarkar KS, Dai M, Chen HH, Sosnovik DE, Shin JT, Haber DA, Berman JN, Chao W, Peterson RT. Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase. Sci Transl Med. 2014 Dec 10; 6(266):266ra170. PMID: 25504881.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  30. Cui J, Kessinger CW, McCarthy JR, Sosnovik DE, Libby P, Thadhani RI, Jaffer FA. In vivo nanoparticle assessment of pathological endothelium predicts the development of inflow stenosis in murine arteriovenous fistula. Arterioscler Thromb Vasc Biol. 2015 Jan; 35(1):189-96. PMID: 25395614.
    Citations: 3     Fields:    Translation:Animals
  31. Stoeck CT, Kalinowska A, von Deuster C, Harmer J, Chan RW, Niemann M, Manka R, Atkinson D, Sosnovik DE, Mekkaoui C, Kozerke S. Dual-phase cardiac diffusion tensor imaging with strain correction. PLoS One. 2014; 9(9):e107159. PMID: 25191900.
    Citations: 17     Fields:    Translation:Humans
  32. Figge L, Appler F, Chen HH, Sosnovik DE, Schnorr J, Seitz O, Taupitz M, Hamm B, Schellenberger E. Direct coupling of annexin A5 to VSOP yields small, protein-covered nanoprobes for MR imaging of apoptosis. Contrast Media Mol Imaging. 2014 Jul-Aug; 9(4):291-9. PMID: 24706613.
    Citations: 1     Fields:    Translation:Humans
  33. Sosnovik DE, Mekkaoui C, Huang S, Chen HH, Dai G, Stoeck CT, Ngoy S, Guan J, Wang R, Kostis WJ, Jackowski MP, Wedeen VJ, Kozerke S, Liao R. Microstructural impact of ischemia and bone marrow-derived cell therapy revealed with diffusion tensor magnetic resonance imaging tractography of the heart in vivo. Circulation. 2014 Apr 29; 129(17):1731-41. PMID: 24619466.
    Citations: 27     Fields:    Translation:HumansAnimalsCTClinical Trials
  34. Chen C, Feng Y, Zou L, Wang L, Chen HH, Cai JY, Xu JM, Sosnovik DE, Chao W. Role of extracellular RNA and TLR3-Trif signaling in myocardial ischemia-reperfusion injury. J Am Heart Assoc. 2014 Jan 03; 3(1):e000683. PMID: 24390148.
    Citations: 23     Fields:    Translation:AnimalsCells
  35. Caravan P, Yang Y, Zachariah R, Schmitt A, Mino-Kenudson M, Chen HH, Sosnovik DE, Dai G, Fuchs BC, Lanuti M. Molecular magnetic resonance imaging of pulmonary fibrosis in mice. Am J Respir Cell Mol Biol. 2013 Dec; 49(6):1120-6. PMID: 23927643.
    Citations: 20     Fields:    Translation:HumansAnimals
  36. Yuan H, Cho H, Chen HH, Panagia M, Sosnovik DE, Josephson L. Fluorescent and radiolabeled triphenylphosphonium probes for imaging mitochondria. Chem Commun (Camb). 2013 Nov 14; 49(88):10361-3. PMID: 24072060.
    Citations: 7     Fields:    
  37. Mekkaoui C, Porayette P, Jackowski MP, Kostis WJ, Dai G, Sanders S, Sosnovik DE. Diffusion MRI tractography of the developing human fetal heart. PLoS One. 2013; 8(8):e72795. PMID: 23991152.
    Citations: 10     Fields:    Translation:Humans
  38. Cho H, Guo Y, Sosnovik DE, Josephson L. Imaging DNA with fluorochrome bearing metals. Inorg Chem. 2013 Nov 04; 52(21):12216-22. PMID: 23646914.
    Citations:    Fields:    Translation:HumansAnimals
  39. Chen HH, Mekkaoui C, Cho H, Ngoy S, Marinelli B, Waterman P, Nahrendorf M, Liao R, Josephson L, Sosnovik DE. Fluorescence tomography of rapamycin-induced autophagy and cardioprotection in vivo. Circ Cardiovasc Imaging. 2013 May 01; 6(3):441-7. PMID: 23537953.
    Citations: 8     Fields:    Translation:AnimalsCells
  40. Károlyi M, Seifarth H, Liew G, Schlett CL, Maurovich-Horvat P, Stolzmann P, Dai G, Huang S, Goergen CJ, Nakano M, Otsuka F, Virmani R, Hoffmann U, Sosnovik DE. Classification of coronary atherosclerotic plaques ex vivo with T1, T2, and ultrashort echo time CMR. JACC Cardiovasc Imaging. 2013 Apr; 6(4):466-74. PMID: 23498670.
    Citations: 2     Fields:    Translation:Humans
  41. Cho H, Alcantara D, Yuan H, Sheth RA, Chen HH, Huang P, Andersson SB, Sosnovik DE, Mahmood U, Josephson L. Fluorochrome-functionalized nanoparticles for imaging DNA in biological systems. ACS Nano. 2013 Mar 26; 7(3):2032-41. PMID: 23373524.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  42. McGill LA, Ismail TF, Nielles-Vallespin S, Ferreira P, Scott AD, Roughton M, Kilner PJ, Ho SY, McCarthy KP, Gatehouse PD, de Silva R, Speier P, Feiweier T, Mekkaoui C, Sosnovik DE, Prasad SK, Firmin DN, Pennell DJ. Reproducibility of in-vivo diffusion tensor cardiovascular magnetic resonance in hypertrophic cardiomyopathy. J Cardiovasc Magn Reson. 2012 Dec 24; 14:86. PMID: 23259835.
    Citations: 28     Fields:    Translation:Humans
  43. Bauer M, Kang L, Qiu Y, Wu J, Peng M, Chen HH, Camci-Unal G, Bayomy AF, Sosnovik DE, Khademhosseini A, Liao R. Adult cardiac progenitor cell aggregates exhibit survival benefit both in vitro and in vivo. PLoS One. 2012; 7(11):e50491. PMID: 23226295.
    Citations: 10     Fields:    Translation:AnimalsCells
  44. Sosnovik DE, Caravan P. Molecular MRI of the Cardiovascular System in the Post-NSF Era. Curr Cardiovasc Imaging Rep. 2013 Feb 01; 6(1):61-68. PMID: 23504765.
    Citations:    
  45. Mekkaoui C, Huang S, Chen HH, Dai G, Reese TG, Kostis WJ, Thiagalingam A, Maurovich-Horvat P, Ruskin JN, Hoffmann U, Jackowski MP, Sosnovik DE. Fiber architecture in remodeled myocardium revealed with a quantitative diffusion CMR tractography framework and histological validation. J Cardiovasc Magn Reson. 2012 Oct 12; 14:70. PMID: 23061749.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  46. Nielles-Vallespin S, Mekkaoui C, Gatehouse P, Reese TG, Keegan J, Ferreira PF, Collins S, Speier P, Feiweier T, de Silva R, Jackowski MP, Pennell DJ, Sosnovik DE, Firmin D. In vivo diffusion tensor MRI of the human heart: reproducibility of breath-hold and navigator-based approaches. Magn Reson Med. 2013 Aug; 70(2):454-65. PMID: 23001828.
    Citations: 34     Fields:    Translation:Humans
  47. Goergen CJ, Radhakrishnan H, Sakadžic S, Mandeville ET, Lo EH, Sosnovik DE, Srinivasan VJ. Optical coherence tractography using intrinsic contrast. Opt Lett. 2012 Sep 15; 37(18):3882-4. PMID: 23041891.
    Citations: 14     Fields:    Translation:AnimalsCells
  48. Sosnovik DE, Nahrendorf M. Cells and iron oxide nanoparticles on the move: magnetic resonance imaging of monocyte homing and myocardial inflammation in patients with ST-elevation myocardial infarction. Circ Cardiovasc Imaging. 2012 Sep 01; 5(5):551-4. PMID: 22991284.
    Citations: 10     Fields:    Translation:Humans
  49. Sosnovik DE, Nahrendorf M, Caravan P. Science to practice: how will myocardial inflammation be imaged with MR imaging? Radiology. 2012 Aug; 264(2):309-11. PMID: 22821689.
    Citations:    Fields:    Translation:AnimalsCells
  50. Alcantara D, Guo Y, Yuan H, Goergen CJ, Chen HH, Cho H, Sosnovik DE, Josephson L. Fluorochrome-functionalized magnetic nanoparticles for high-sensitivity monitoring of the polymerase chain reaction by magnetic resonance. Angew Chem Int Ed Engl. 2012 Jul 09; 51(28):6904-7. PMID: 22684680.
    Citations: 3     Fields:    
  51. Goergen CJ, Chen HH, Bogdanov A, Sosnovik DE, Kumar AT. In vivo fluorescence lifetime detection of an activatable probe in infarcted myocardium. J Biomed Opt. 2012 May; 17(5):056001. PMID: 22612124.
    Citations: 6     Fields:    Translation:Animals
  52. Chen HH, Yuan H, Josephson L, Sosnovik DE. Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival. Theranostics. 2012; 2(2):148-55. PMID: 22400062.
    Citations: 3     Fields:    
  53. Rosenberg MA, Das S, Quintero Pinzon P, Knight AC, Sosnovik DE, Ellinor PT, Rosenzweig A. A Novel Transgenic Mouse Model of Cardiac Hypertrophy and Atrial Fibrillation. J Atr Fibrillation. 2012 Feb-Mar; 4(5):415. PMID: 28496713.
    Citations: 8     
  54. Rosenberg MA, Das S, Pinzon PQ, Knight AC, Sosnovik DE, Ellinor PT, Rosenzweig A. A Novel Transgenic Mouse Model of Cardiac Hypertrophy and Atrial Fibrillation. J Atr Fibrillation. 2012 Feb; 2(9):1-15. PMID: 23243484.
    Citations:    
  55. Huang S, Chen HH, Yuan H, Dai G, Schuhle DT, Mekkaoui C, Ngoy S, Liao R, Caravan P, Josephson L, Sosnovik DE. Molecular MRI of acute necrosis with a novel DNA-binding gadolinium chelate: kinetics of cell death and clearance in infarcted myocardium. Circ Cardiovasc Imaging. 2011 Nov; 4(6):729-37. PMID: 21836081.
    Citations: 17     Fields:    Translation:AnimalsCells
  56. Nahrendorf M, Sosnovik DE. Science to practice: will magnetic guidance of microbubbles play a role in clinical molecular imaging? Radiology. 2011 Aug; 260(2):309-10. PMID: 21778448.
    Citations: 1     Fields:    Translation:Animals
  57. Li Y, Si R, Feng Y, Chen HH, Zou L, Wang E, Zhang M, Warren HS, Sosnovik DE, Chao W. Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll-like receptor 4. J Biol Chem. 2011 Sep 09; 286(36):31308-19. PMID: 21775438.
    Citations: 37     Fields:    Translation:AnimalsCells
  58. Chen HH, Feng Y, Zhang M, Chao W, Josephson L, Shaw SY, Sosnovik DE. Protective effect of the apoptosis-sensing nanoparticle AnxCLIO-Cy5.5. Nanomedicine. 2012 Apr; 8(3):291-8. PMID: 21704591.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  59. Goergen CJ, Sosnovik DE. From molecules to myofibers: multiscale imaging of the myocardium. J Cardiovasc Transl Res. 2011 Aug; 4(4):493-503. PMID: 21643889.
    Citations: 6     Fields:    Translation:HumansAnimals
  60. Berry NC, Sosnovik DE. Cardiomyocyte death: insights from molecular and microstructural magnetic resonance imaging. Pediatr Cardiol. 2011 Mar; 32(3):290-6. PMID: 21298427.
    Citations:    Fields:    Translation:HumansCells
  61. Chen HH, Josephson L, Sosnovik DE. Imaging of apoptosis in the heart with nanoparticle technology. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2011 Jan-Feb; 3(1):86-99. PMID: 20945336.
    Citations: 6     Fields:    Translation:HumansAnimals
  62. Leuschner F, Panizzi P, Chico-Calero I, Lee WW, Ueno T, Cortez-Retamozo V, Waterman P, Gorbatov R, Marinelli B, Iwamoto Y, Chudnovskiy A, Figueiredo JL, Sosnovik DE, Pittet MJ, Swirski FK, Weissleder R, Nahrendorf M. Angiotensin-converting enzyme inhibition prevents the release of monocytes from their splenic reservoir in mice with myocardial infarction. Circ Res. 2010 Nov 26; 107(11):1364-73. PMID: 20930148.
    Citations: 79     Fields:    Translation:AnimalsCells
  63. Kramer CM, Sinusas AJ, Sosnovik DE, French BA, Bengel FM. Multimodality imaging of myocardial injury and remodeling. J Nucl Med. 2010 May 01; 51 Suppl 1:107S-121S. PMID: 20395347.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  64. Panizzi P, Swirski FK, Figueiredo JL, Waterman P, Sosnovik DE, Aikawa E, Libby P, Pittet M, Weissleder R, Nahrendorf M. Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis. J Am Coll Cardiol. 2010 Apr 13; 55(15):1629-38. PMID: 20378083.
    Citations: 95     Fields:    Translation:AnimalsCells
  65. Huang S, Sosnovik DE. Molecular and Microstructural Imaging of the Myocardium. Curr Cardiovasc Imaging Rep. 2010 Feb; 3(1):26-33. PMID: 20689659.
    Citations: 3     
  66. Sosnovik DE, Wang R, Dai G, Reese TG, Wedeen VJ. Diffusion MR tractography of the heart. J Cardiovasc Magn Reson. 2009 Nov 13; 11:47. PMID: 19912654.
    Citations: 49     Fields:    Translation:HumansAnimals
  67. Sosnovik DE, Garanger E, Aikawa E, Nahrendorf M, Figuiredo JL, Dai G, Reynolds F, Rosenzweig A, Weissleder R, Josephson L. Molecular MRI of cardiomyocyte apoptosis with simultaneous delayed-enhancement MRI distinguishes apoptotic and necrotic myocytes in vivo: potential for midmyocardial salvage in acute ischemia. Circ Cardiovasc Imaging. 2009 Nov; 2(6):460-7. PMID: 19920044.
    Citations: 36     Fields:    Translation:AnimalsCells
  68. Sosnovik DE, Nahrendorf M, Panizzi P, Matsui T, Aikawa E, Dai G, Li L, Reynolds F, Dorn GW, Weissleder R, Josephson L, Rosenzweig A. Molecular MRI detects low levels of cardiomyocyte apoptosis in a transgenic model of chronic heart failure. Circ Cardiovasc Imaging. 2009 Nov; 2(6):468-75. PMID: 19920045.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  69. Garanger E, Hilderbrand SA, Blois JT, Sosnovik DE, Weissleder R, Josephson L. A DNA-binding Gd chelate for the detection of cell death by MRI. Chem Commun (Camb). 2009 Aug 07; (29):4444-6. PMID: 19597620.
    Citations: 11     Fields:    Translation:Cells
  70. Figueiredo JL, Nahrendorf M, Sosnovik DE, Weissleder R. MRI of a novel murine working heart transplant model. Circ Heart Fail. 2009 May; 2(3):272-4. PMID: 19718275.
    Citations: 3     Fields:    Translation:Animals
  71. Sosnovik DE. Will molecular MR imaging play a role in identification and treatment of patients with vulnerable atherosclerotic plaques? Radiology. 2009 May; 251(2):309-10. PMID: 19401565.
    Citations:    Fields:    Translation:Humans
  72. Sosnovik DE, Caravan P. Molecular MRI of Atherosclerotic Plaque With Targeted Contrast Agents. Curr Cardiovasc Imaging Rep. 2009 Apr 01; 2(2):87-94. PMID: 20019886.
    Citations: 4     
  73. Sosnovik DE, Wang R, Dai G, Wang T, Aikawa E, Novikov M, Rosenzweig A, Gilbert RJ, Wedeen VJ. Diffusion spectrum MRI tractography reveals the presence of a complex network of residual myofibers in infarcted myocardium. Circ Cardiovasc Imaging. 2009 May; 2(3):206-12. PMID: 19808594.
    Citations: 42     Fields:    Translation:AnimalsCells
  74. Sosnovik DE. Molecular Imaging of Myocardial Injury: A Magnetofluorescent Approach. Curr Cardiovasc Imaging Rep. 2009 Feb 01; 2(1):33-39. PMID: 20090858.
    Citations: 2     
  75. Nahrendorf M, Sosnovik DE, French BA, Swirski FK, Bengel F, Sadeghi MM, Lindner JR, Wu JC, Kraitchman DL, Fayad ZA, Sinusas AJ. Multimodality cardiovascular molecular imaging, Part II. Circ Cardiovasc Imaging. 2009 Jan; 2(1):56-70. PMID: 19808565.
    Citations: 56     Fields:    Translation:Humans
  76. Korosoglou G, Shah S, Vonken EJ, Gilson WD, Schär M, Tang L, Kraitchman DL, Boston RC, Sosnovik DE, Weiss RG, Weissleder R, Stuber M. Off-resonance angiography: a new method to depict vessels--phantom and rabbit studies. Radiology. 2008 Nov; 249(2):501-9. PMID: 18780823.
    Citations: 10     Fields:    Translation:Animals
  77. Korosoglou G, Weiss RG, Kedziorek DA, Walczak P, Gilson WD, Schär M, Sosnovik DE, Kraitchman DL, Boston RC, Bulte JW, Weissleder R, Stuber M. Noninvasive detection of macrophage-rich atherosclerotic plaque in hyperlipidemic rabbits using "positive contrast" magnetic resonance imaging. J Am Coll Cardiol. 2008 Aug 05; 52(6):483-91. PMID: 18672170.
    Citations: 45     Fields:    Translation:AnimalsCells
  78. Sosnovik DE, Nahrendorf M, Weissleder R. Targeted imaging of myocardial damage. Nat Clin Pract Cardiovasc Med. 2008 Aug; 5 Suppl 2:S63-70. PMID: 18641609.
    Citations: 13     Fields:    Translation:HumansAnimals
  79. Schmitt M, Potthast A, Sosnovik DE, Polimeni JR, Wiggins GC, Triantafyllou C, Wald LL. A 128-channel receive-only cardiac coil for highly accelerated cardiac MRI at 3 Tesla. Magn Reson Med. 2008 Jun; 59(6):1431-9. PMID: 18506789.
    Citations: 42     Fields:    Translation:Humans
  80. Farrar CT, Dai G, Novikov M, Rosenzweig A, Weissleder R, Rosen BR, Sosnovik DE. Impact of field strength and iron oxide nanoparticle concentration on the linearity and diagnostic accuracy of off-resonance imaging. NMR Biomed. 2008 Jun; 21(5):453-63. PMID: 17918777.
    Citations: 27     Fields:    Translation:AnimalsCells
  81. Korngold EC, Jaffer FA, Weissleder R, Sosnovik DE. Noninvasive imaging of apoptosis in cardiovascular disease. Heart Fail Rev. 2008 Jun; 13(2):163-73. PMID: 18074226.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  82. Korosoglou G, Tang L, Kedziorek D, Cosby K, Gilson WD, Vonken EJ, Schär M, Sosnovik D, Kraitchman DL, Weiss RG, Weissleder R, Stuber M. Positive contrast MR-lymphography using inversion recovery with ON-resonant water suppression (IRON). J Magn Reson Imaging. 2008 May; 27(5):1175-80. PMID: 18425827.
    Citations: 7     Fields:    Translation:Animals
  83. Sosnovik DE, Nahrendorf M, Weissleder R. Magnetic nanoparticles for MR imaging: agents, techniques and cardiovascular applications. Basic Res Cardiol. 2008 Mar; 103(2):122-30. PMID: 18324368.
    Citations: 49     Fields:    Translation:HumansAnimals
  84. Nahrendorf M, Sosnovik DE, Weissleder R. MR-optical imaging of cardiovascular molecular targets. Basic Res Cardiol. 2008 Mar; 103(2):87-94. PMID: 18324364.
    Citations: 11     Fields:    Translation:HumansAnimals
  85. Nahrendorf M, Sosnovik D, Chen JW, Panizzi P, Figueiredo JL, Aikawa E, Libby P, Swirski FK, Weissleder R. Activatable magnetic resonance imaging agent reports myeloperoxidase activity in healing infarcts and noninvasively detects the antiinflammatory effects of atorvastatin on ischemia-reperfusion injury. Circulation. 2008 Mar 04; 117(9):1153-60. PMID: 18268141.
    Citations: 59     Fields:    Translation:Animals
  86. Sosnovik DE. Molecular imaging in cardiovascular magnetic resonance imaging: current perspective and future potential. Top Magn Reson Imaging. 2008 Feb; 19(1):59-68. PMID: 18690161.
    Citations: 12     Fields:    Translation:HumansAnimals
  87. Nahrendorf M, Aikawa E, Figueiredo JL, Stangenberg L, van den Borne SW, Blankesteijn WM, Sosnovik DE, Jaffer FA, Tung CH, Weissleder R. Transglutaminase activity in acute infarcts predicts healing outcome and left ventricular remodelling: implications for FXIII therapy and antithrombin use in myocardial infarction. Eur Heart J. 2008 Feb; 29(4):445-54. PMID: 18276618.
    Citations: 22     Fields:    Translation:HumansAnimals
  88. Nahrendorf M, Zhang H, Hembrador S, Panizzi P, Sosnovik DE, Aikawa E, Libby P, Swirski FK, Weissleder R. Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis. Circulation. 2008 Jan 22; 117(3):379-87. PMID: 18158358.
    Citations: 167     Fields:    Translation:AnimalsCells
  89. Taktak S, Sosnovik D, Cima MJ, Weissleder R, Josephson L. Multiparameter magnetic relaxation switch assays. Anal Chem. 2007 Dec 01; 79(23):8863-9. PMID: 17983206.
    Citations: 12     Fields:    
  90. Sosnovik DE, Dai G, Nahrendorf M, Rosen BR, Seethamraju R. Cardiac MRI in mice at 9.4 Tesla with a transmit-receive surface coil and a cardiac-tailored intensity-correction algorithm. J Magn Reson Imaging. 2007 Aug; 26(2):279-87. PMID: 17654729.
    Citations: 8     Fields:    Translation:Animals
  91. Sosnovik DE, Nahrendorf M, Weissleder R. Molecular magnetic resonance imaging in cardiovascular medicine. Circulation. 2007 Apr 17; 115(15):2076-86. PMID: 17438163.
    Citations: 41     Fields:    Translation:HumansAnimals
  92. Nahrendorf M, Sosnovik DE, Waterman P, Swirski FK, Pande AN, Aikawa E, Figueiredo JL, Pittet MJ, Weissleder R. Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct. Circ Res. 2007 Apr 27; 100(8):1218-25. PMID: 17379832.
    Citations: 72     Fields:    Translation:AnimalsCells
  93. Sosnovik DE, Nahrendorf M, Deliolanis N, Novikov M, Aikawa E, Josephson L, Rosenzweig A, Weissleder R, Ntziachristos V. Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo. Circulation. 2007 Mar 20; 115(11):1384-91. PMID: 17339546.
    Citations: 75     Fields:    Translation:AnimalsCells
  94. Nahrendorf M, Badea C, Hedlund LW, Figueiredo JL, Sosnovik DE, Johnson GA, Weissleder R. High-resolution imaging of murine myocardial infarction with delayed-enhancement cine micro-CT. Am J Physiol Heart Circ Physiol. 2007 Jun; 292(6):H3172-8. PMID: 17322414.
    Citations: 25     Fields:    Translation:Animals
  95. Abbara S, Pena AJ, Maurovich-Horvat P, Butler J, Sosnovik DE, Lembcke A, Cury RC, Hoffmann U, Ferencik M, Brady TJ. Feasibility and optimization of aortic valve planimetry with MDCT. AJR Am J Roentgenol. 2007 Feb; 188(2):356-60. PMID: 17242242.
    Citations: 4     Fields:    Translation:Humans
  96. Aikawa E, Nahrendorf M, Sosnovik D, Lok VM, Jaffer FA, Aikawa M, Weissleder R. Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease. Circulation. 2007 Jan 23; 115(3):377-86. PMID: 17224478.
    Citations: 122     Fields:    Translation:AnimalsCells
  97. Sosnovik DE, Weissleder R. Emerging concepts in molecular MRI. Curr Opin Biotechnol. 2007 Feb; 18(1):4-10. PMID: 17126545.
    Citations: 34     Fields:    Translation:Animals
  98. Jaffer FA, Sosnovik DE, Nahrendorf M, Weissleder R. Molecular imaging of myocardial infarction. J Mol Cell Cardiol. 2006 Dec; 41(6):921-33. PMID: 17067633.
    Citations: 15     Fields:    Translation:HumansAnimals
  99. Nahrendorf M, Jaffer FA, Kelly KA, Sosnovik DE, Aikawa E, Libby P, Weissleder R. Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis. Circulation. 2006 Oct 03; 114(14):1504-11. PMID: 17000904.
    Citations: 167     Fields:    Translation:AnimalsCells
  100. Jaffer FA, Nahrendorf M, Sosnovik D, Kelly KA, Aikawa E, Weissleder R. Cellular imaging of inflammation in atherosclerosis using magnetofluorescent nanomaterials. Mol Imaging. 2006 Apr-Jun; 5(2):85-92. PMID: 16954022.
    Citations: 49     Fields:    Translation:AnimalsCells
  101. Nahrendorf M, Hu K, Frantz S, Jaffer FA, Tung CH, Hiller KH, Voll S, Nordbeck P, Sosnovik D, Gattenlöhner S, Novikov M, Dickneite G, Reed GL, Jakob P, Rosenzweig A, Bauer WR, Weissleder R, Ertl G. Factor XIII deficiency causes cardiac rupture, impairs wound healing, and aggravates cardiac remodeling in mice with myocardial infarction. Circulation. 2006 Mar 07; 113(9):1196-202. PMID: 16505171.
    Citations: 41     Fields:    Translation:AnimalsCells
  102. Nahrendorf M, Streif JU, Hiller KH, Hu K, Nordbeck P, Ritter O, Sosnovik D, Bauer L, Neubauer S, Jakob PM, Ertl G, Spindler M, Bauer WR. Multimodal functional cardiac MRI in creatine kinase-deficient mice reveals subtle abnormalities in myocardial perfusion and mechanics. Am J Physiol Heart Circ Physiol. 2006 Jun; 290(6):H2516-21. PMID: 16415075.
    Citations: 20     Fields:    Translation:AnimalsCells
  103. Sosnovik DE, Schellenberger EA, Nahrendorf M, Novikov MS, Matsui T, Dai G, Reynolds F, Grazette L, Rosenzweig A, Weissleder R, Josephson L. Magnetic resonance imaging of cardiomyocyte apoptosis with a novel magneto-optical nanoparticle. Magn Reson Med. 2005 Sep; 54(3):718-24. PMID: 16086367.
    Citations: 69     Fields:    Translation:AnimalsCells
  104. Baldwin SL, Holland MR, Sosnovik DE, Miller JG. Effects of region-of-interest length on estimates of myocardial ultrasonic attenuation and backscatter. Med Phys. 2005 Feb; 32(2):418-26. PMID: 15789588.
    Citations: 2     Fields:    Translation:Animals
  105. Sosnovik D, Weissleder R. Magnetic resonance and fluorescence based molecular imaging technologies. Prog Drug Res. 2005; 62:83-115. PMID: 16329255.
    Citations: 8     Fields:    Translation:HumansAnimals
  106. Schellenberger EA, Sosnovik D, Weissleder R, Josephson L. Magneto/optical annexin V, a multimodal protein. Bioconjug Chem. 2004 Sep-Oct; 15(5):1062-7. PMID: 15366960.
    Citations: 45     Fields:    Translation:HumansCells
  107. Hoffmann U, Millea R, Enzweiler C, Ferencik M, Gulick S, Titus J, Achenbach S, Kwait D, Sosnovik D, Brady TJ. Acute myocardial infarction: contrast-enhanced multi-detector row CT in a porcine model. Radiology. 2004 Jun; 231(3):697-701. PMID: 15118118.
    Citations: 29     Fields:    Translation:Animals
  108. Mansour M, Holmvang G, Sosnovik D, Migrino R, Abbara S, Ruskin J, Keane D. Assessment of pulmonary vein anatomic variability by magnetic resonance imaging: implications for catheter ablation techniques for atrial fibrillation. J Cardiovasc Electrophysiol. 2004 Apr; 15(4):387-93. PMID: 15089984.
    Citations: 42     Fields:    Translation:Humans
  109. Abbara S, Migrino RQ, Sosnovik DE, Leichter JA, Brady TJ, Holmvang G. Value of fat suppression in the MRI evaluation of suspected arrhythmogenic right ventricular dysplasia. AJR Am J Roentgenol. 2004 Mar; 182(3):587-91. PMID: 14975951.
    Citations: 6     Fields:    Translation:Humans
  110. Sosnovik DE, Januzzi JL, Church CC, Mertsch JA, Sears AL, Fetterman RC, Walovitch RC, Picard MH. Measurement of radial artery contrast intensity to assess cardiac microbubble behavior. J Am Soc Echocardiogr. 2003 Dec; 16(12):1267-73. PMID: 14652606.
    Citations:    Fields:    Translation:Humans
  111. Sosnovik DE, Muller JE, Kathiresan S, Brady TJ. Non-invasive imaging of plaque vulnerability: an important tool for the assessment of agents to stabilise atherosclerotic plaques. Expert Opin Investig Drugs. 2002 May; 11(5):693-704. PMID: 11996650.
    Citations:    Fields:    Translation:HumansAnimals
  112. Sosnovik DE, Baldwin SL, Lewis SH, Holland MR, Miller JG. Transmural variation of myocardial attenuation measured with a clinical imager. Ultrasound Med Biol. 2001 Dec; 27(12):1643-50. PMID: 11839409.
    Citations: 8     Fields:    Translation:Animals
  113. Sosnovik DE, Baldwin SL, Holland MR, Miller JG. Transmural variation of myocardial attenuation and its potential effect on contrast-mediated estimates of regional myocardial perfusion. J Am Soc Echocardiogr. 2001 Aug; 14(8):782-8. PMID: 11490326.
    Citations:    Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.