Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Daniel C. Chung, M.D.

Title
Institution
Department
Address
Phone
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Mentoring
completed student projects
The role of Egr-1 in the HIF-1-independent regulation of VEGF in colon cancer
Summer, 06/13/04 - 08/20/04

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. U01CA243695 (CHUNG, DANIEL C) Sep 14, 2020 - Aug 31, 2025
    NIH
    Development and Implementation of ElectronicDecision Aids for Genetic Testing in Inherited Cancer Syndromes
    Role: Principal Investigator
  2. R01CA092594 (CHUNG, DANIEL C) Jul 1, 2001 - Mar 31, 2013
    NIH
    Genetic Regulation of Angiogenesis in Colonic Polyps
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Folkerts EK, Pelletier REC, Chung DC, Goldstein SA, Micalizzi DS, Shannon KM, Sweetser DA, Wong EK, Rehm HL, Hull LE. A Pooled Electronic Consultation Program to Improve Access to Genetics Specialists. medRxiv. 2023 Feb 10. PMID: 36798390; PMCID: PMC9934799.
    Citations:    
  2. Feldman D, Rodgers-Fouche L, Hicks S, Chung DC. Clinical features and long-term outcomes of patients with colonic oligopolyposis of unknown etiology. World J Gastroenterol. 2022 Dec 28; 28(48):6950-6961. PMID: 36632322; PMCID: PMC9827588.
    Citations:    Fields:    Translation:Humans
  3. DelSignore M, Jeong T, Denmark G, Feldman D, Shih A, Zukerberg L, Chung DC. Incidence and natural history of gastric high-grade dysplasia in patients with familial adenomatous polyposis syndrome. Gastrointest Endosc. 2023 01; 97(1):25-34.e6. PMID: 36113625.
    Citations:    Fields:    Translation:Humans
  4. Leroy BP, Fischer MD, Flannery JG, MacLaren RE, Dalkara D, Scholl HPN, Chung DC, Spera C, Viriato D, Banhazi J. Gene therapy for inherited retinal disease: long-term durability of effect. Ophthalmic Res. 2022 Sep 14. PMID: 36103843.
    Citations: 2     Fields:    
  5. Siegel A, Friedman M, Feldman D, Krishnan K, Casey B, Pisuchpen N, Kambadakone A, Chung DC. Concordance of EUS and MRI/MRCP findings among high-risk individuals undergoing pancreatic cancer screening. Pancreatology. 2022 Nov; 22(7):951-958. PMID: 35995658.
    Citations:    Fields:    Translation:Humans
  6. Aleman TS, Huckfeldt RM, Serrano LW, Pearson DJ, Vergilio GK, McCague S, Marshall KA, Ashtari M, Doan TM, Weigel-DiFranco CA, Biron BS, Wen XH, Chung DC, Liu E, Ferenchak K, Morgan JIW, Pierce EA, Eliott D, Bennett J, Comander J, Maguire AM. Adeno-Associated Virus Serotype 2-hCHM Subretinal Delivery to the Macula in Choroideremia: Two-Year Interim Results of an Ongoing Phase I/II Gene Therapy Trial. Ophthalmology. 2022 10; 129(10):1177-1191. PMID: 35714735.
    Citations: 1     Fields:    Translation:HumansCellsCTClinical Trials
  7. Shaukat A, Lichtenstein DR, Somers SC, Chung DC, Perdue DG, Gopal M, Colucci DR, Phillips SA, Marka NA, Church TR, Brugge WR. Computer-Aided Detection Improves Adenomas per Colonoscopy for Screening and Surveillance Colonoscopy: A Randomized Trial. Gastroenterology. 2022 09; 163(3):732-741. PMID: 35643173.
    Citations: 4     Fields:    Translation:Humans
  8. Brand RE, Persson J, Bratlie SO, Chung DC, Katona BW, Carrato A, Castillo M, Earl J, Kokkola A, Lucas AL, Moser AJ, DeCicco C, Mellby LD, King TC. Detection of Early-Stage Pancreatic Ductal Adenocarcinoma From Blood Samples: Results of a Multiplex Biomarker Signature Validation Study. Clin Transl Gastroenterol. 2022 02 14; 13(3):e00468. PMID: 35166713; PMCID: PMC8963856.
    Citations: 2     Fields:    Translation:Humans
  9. Weiss JM, Gupta S, Burke CA, Axell L, Chen LM, Chung DC, Clayback KM, Dallas S, Felder S, Gbolahan O, Giardiello FM, Grady W, Hall MJ, Hampel H, Hodan R, Idos G, Kanth P, Katona B, Lamps L, Llor X, Lynch PM, Markowitz AJ, Pirzadeh-Miller S, Samadder NJ, Shibata D, Swanson BJ, Szymaniak BM, Wiesner GL, Wolf A, Yurgelun MB, Zakhour M, Darlow SD, Dwyer MA, Campbell M. NCCN Guidelines® Insights: Genetic/Familial High-Risk Assessment: Colorectal, Version 1.2021. J Natl Compr Canc Netw. 2021 10 15; 19(10):1122-1132. PMID: 34666312.
    Citations: 45     Fields:    Translation:Humans
  10. Chung DC, Birch DG, MacLaren RE. Endpoints for Measuring Efficacy in Clinical Trials for Inherited Retinal Disease. Int Ophthalmol Clin. 2021 10 01; 61(4):63-78. PMID: 34584045.
    Citations:    Fields:    Translation:Humans
  11. Li H, Rajani V, Han L, Chung D, Cooke JE, Sengar AS, Salter MW. Alternative splicing of GluN1 gates glycine site-dependent nonionotropic signaling by NMDAR receptors. Proc Natl Acad Sci U S A. 2021 07 06; 118(27). PMID: 34187890.
    Citations: 3     Fields:    Translation:AnimalsCells
  12. Petersen AØ, Jokinen M, Plichta DR, Liebisch G, Gronwald W, Dettmer K, Oefner PJ, Vlamakis H, Chung DC, Ranki A, Xavier RJ. Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1. J Allergy Clin Immunol. 2021 09; 148(3):876-888. PMID: 33819509; PMCID: PMC8429070.
    Citations: 2     Fields:    Translation:HumansCells
  13. Maguire AM, Russell S, Chung DC, Yu ZF, Tillman A, Drack AV, Simonelli F, Leroy BP, Reape KZ, High KA, Bennett J. Durability of Voretigene Neparvovec for Biallelic RPE65-Mediated Inherited Retinal Disease: Phase 3 Results at 3 and 4 Years. Ophthalmology. 2021 10; 128(10):1460-1468. PMID: 33798654.
    Citations: 24     Fields:    Translation:HumansCTClinical Trials
  14. Plichta DR, Somani J, Pichaud M, Wallace ZS, Fernandes AD, Perugino CA, Lähdesmäki H, Stone JH, Vlamakis H, Chung DC, Khanna D, Pillai S, Xavier RJ. Congruent microbiome signatures in fibrosis-prone autoimmune diseases: IgG4-related disease and systemic sclerosis. Genome Med. 2021 02 28; 13(1):35. PMID: 33648559; PMCID: PMC7919092.
    Citations: 13     Fields:    Translation:HumansCells
  15. Friedman M, Rand K, Patel T, Colizzo F, Carolan P, Kelsey P, Chung DC. A pilot study of virtual reality as an alternative to pharmacological sedation during colonoscopy. Endosc Int Open. 2021 Mar; 9(3):E343-E347. PMID: 33655032.
    Citations: 1     
  16. Drew DA, Schuck MM, Magicheva-Gupta MV, Stewart KO, Gilpin KK, Miller P, Parziale MP, Pond EN, Takacsi-Nagy O, Zerjav DC, Chin SM, Mackinnon Krems J, Meixell D, Joshi AD, Ma W, Colizzo FP, Carolan PJ, Nishioka NS, Staller K, Richter JM, Khalili H, Gala MK, Garber JJ, Chung DC, Yarze JC, Zukerberg L, Petrucci G, Rocca B, Patrono C, Milne GL, Wang M, Chan AT. Effect of Low-dose and Standard-dose Aspirin on PGE2 Biosynthesis Among Individuals with Colorectal Adenomas: A Randomized Clinical Trial. Cancer Prev Res (Phila). 2020 10; 13(10):877-888. PMID: 32718943.
    Citations: 11     Fields:    Translation:HumansCTClinical Trials
  17. Maxner B, McGoldrick J, Bellavance D, Liu PH, Xavier RJ, Yarze JC, Ricciardi R, Staller K, Chung DC, Khalili H. Fruit and vegetable consumption is associated with lower prevalence of asymptomatic diverticulosis: a cross-sectional colonoscopy-based study. BMC Gastroenterol. 2020 Jul 11; 20(1):221. PMID: 32652931; PMCID: PMC7353809.
    Citations:    Fields:    Translation:HumansAnimals
  18. Yan Y, Drew DA, Markowitz A, Lloyd-Price J, Abu-Ali G, Nguyen LH, Tran C, Chung DC, Gilpin KK, Meixell D, Parziale M, Schuck M, Patel Z, Richter JM, Kelsey PB, Garrett WS, Chan AT, Stadler ZK, Huttenhower C. Structure of the Mucosal and Stool Microbiome in Lynch Syndrome. Cell Host Microbe. 2020 04 08; 27(4):585-600.e4. PMID: 32240601.
    Citations: 16     Fields:    Translation:HumansCells
  19. Underhill ML, Pozzar R, Chung D, Sawhney M, Yurgelun M. Health Care Provider Perceptions of Caring for Individuals with Inherited Pancreatic Cancer Risk. J Cancer Educ. 2020 02; 35(1):194-203. PMID: 31701425.
    Citations: 1     Fields:    Translation:Humans
  20. Underhill ML, Pozzar R, Chung D, Sawhney M, Yurgelun M. Correction to: Health Care Provider Perceptions of Caring for Individuals with Inherited Pancreatic Cancer Risk. J Cancer Educ. 2020 Feb; 35(1):204. PMID: 31848936.
    Citations:    Fields:    
  21. Friedman M, Chung DC. Reply. Clin Gastroenterol Hepatol. 2020 06; 18(7):1648. PMID: 31958503.
    Citations:    Fields:    Translation:Humans
  22. Friedman M, Adar T, Patel D, Lauwers GY, Yoon SS, Mullen JT, Chung DC. Surveillance Endoscopy in the Management of Hereditary Diffuse Gastric Cancer Syndrome. Clin Gastroenterol Hepatol. 2021 01; 19(1):189-191. PMID: 31678201.
    Citations: 4     Fields:    Translation:Humans
  23. Nguyen LH, Goel A, Chung DC. Pathways of Colorectal Carcinogenesis. Gastroenterology. 2020 01; 158(2):291-302. PMID: 31622622; PMCID: PMC6981255.
    Citations: 93     Fields:    Translation:HumansCells
  24. Cejas P, Drier Y, Dreijerink KMA, Brosens LAA, Deshpande V, Epstein CB, Conemans EB, Morsink FHM, Graham MK, Valk GD, Vriens MR, Castillo CF, Ferrone CR, Adar T, Bowden M, Whitton HJ, Da Silva A, Font-Tello A, Long HW, Gaskell E, Shoresh N, Heaphy CM, Sicinska E, Kulke MH, Chung DC, Bernstein BE, Shivdasani RA. Publisher Correction: Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors. Nat Med. 2019 Oct; 25(10):1627. PMID: 31501535.
    Citations:    Fields:    
  25. Gupta S, Provenzale D, Llor X, Halverson AL, Grady W, Chung DC, Haraldsdottir S, Markowitz AJ, Slavin TP, Hampel H, Ness RM, Weiss JM, Ahnen DJ, Chen LM, Cooper G, Early DS, Giardiello FM, Hall MJ, Hamilton SR, Kanth P, Klapman JB, Lazenby AJ, Lynch PM, Mayer RJ, Mikkelson J, Peter S, Regenbogen SE, Dwyer MA, Ogba N. NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Colorectal, Version 2.2019. J Natl Compr Canc Netw. 2019 09 01; 17(9):1032-1041. PMID: 31487681.
    Citations: 84     Fields:    Translation:Humans
  26. Li S, Chung DC, Mullen JT. Screening high-risk populations for esophageal and gastric cancer. J Surg Oncol. 2019 Oct; 120(5):831-846. PMID: 31373005.
    Citations: 7     Fields:    Translation:Humans
  27. Cejas P, Drier Y, Dreijerink KMA, Brosens LAA, Deshpande V, Epstein CB, Conemans EB, Morsink FHM, Graham MK, Valk GD, Vriens MR, Castillo CF, Ferrone CR, Adar T, Bowden M, Whitton HJ, Da Silva A, Font-Tello A, Long HW, Gaskell E, Shoresh N, Heaphy CM, Sicinska E, Kulke MH, Chung DC, Bernstein BE, Shivdasani RA. Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors. Nat Med. 2019 08; 25(8):1260-1265. PMID: 31263286; PMCID: PMC6919319.
    Citations: 64     Fields:    Translation:HumansCells
  28. Morgan DM, Cao Y, Miller K, McGoldrick J, Bellavance D, Chin SM, Halvorsen S, Maxner B, Richter JM, Sassi S, Burke KE, Yarze JC, Ludvigsson JF, Staller K, Chung DC, Khalili H. Microscopic Colitis Is Characterized by Intestinal Dysbiosis. Clin Gastroenterol Hepatol. 2020 04; 18(4):984-986. PMID: 31254673.
    Citations: 18     Fields:    Translation:Humans
  29. Maguire AM, Russell S, Wellman JA, Chung DC, Yu ZF, Tillman A, Wittes J, Pappas J, Elci O, Marshall KA, McCague S, Reichert H, Davis M, Simonelli F, Leroy BP, Wright JF, High KA, Bennett J. Efficacy, Safety, and Durability of Voretigene Neparvovec-rzyl in RPE65 Mutation-Associated Inherited Retinal Dystrophy: Results of Phase 1 and 3 Trials. Ophthalmology. 2019 09; 126(9):1273-1285. PMID: 31443789.
    Citations: 109     Fields:    Translation:HumansCellsCTClinical Trials
  30. Adar T, Friedman M, Rodgers LH, Shannon KM, Zukerberg LR, Chung DC. Gastric cancer in Lynch syndrome is associated with underlying immune gastritis. J Med Genet. 2019 12; 56(12):844-845. PMID: 31055502.
    Citations: 8     Fields:    Translation:Humans
  31. Chu JN, Choi J, Ostvar S, Torchia JA, Reynolds KL, Tramontano A, Gainor JF, Chung DC, Clark JW, Hur C. Cost-effectiveness of immune checkpoint inhibitors for microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer. Cancer. 2019 01 15; 125(2):278-289. PMID: 30343509.
    Citations: 11     Fields:    Translation:HumansCells
  32. Chung DC, Bertelsen M, Lorenz B, Pennesi ME, Leroy BP, Hamel CP, Pierce E, Sallum J, Larsen M, Stieger K, Preising M, Weleber R, Yang P, Place E, Liu E, Schaefer G, DiStefano-Pappas J, Elci OU, McCague S, Wellman JA, High KA, Reape KZ. The Natural History of Inherited Retinal Dystrophy Due to Biallelic Mutations in the RPE65 Gene. Am J Ophthalmol. 2019 03; 199:58-70. PMID: 30268864; PMCID: PMC6445969.
    Citations: 29     Fields:    Translation:Humans
  33. Provenzale D, Gupta S, Ahnen DJ, Markowitz AJ, Chung DC, Mayer RJ, Regenbogen SE, Blanco AM, Bray T, Cooper G, Early DS, Ford JM, Giardiello FM, Grady W, Hall MJ, Halverson AL, Hamilton SR, Hampel H, Klapman JB, Larson DW, Lazenby AJ, Llor X, Lynch PM, Mikkelson J, Ness RM, Slavin TP, Sugandha S, Weiss JM, Dwyer MA, Ogba N. NCCN Guidelines Insights: Colorectal Cancer Screening, Version 1.2018. J Natl Compr Canc Netw. 2018 08; 16(8):939-949. PMID: 30099370.
    Citations: 62     Fields:    Translation:HumansPHPublic Health
  34. Adar T, Rodgers LH, Shannon KM, Yoshida M, Ma T, Mattia A, Lauwers GY, Iafrate AJ, Hartford NM, Oliva E, Chung DC. Universal screening of both endometrial and colon cancers increases the detection of Lynch syndrome. Cancer. 2018 08 01; 124(15):3145-3153. PMID: 29750335.
    Citations: 29     Fields:    Translation:Humans
  35. Chung DC. Genetic Testing and Early Onset Colon Cancer. Gastroenterology. 2018 03; 154(4):788-789. PMID: 29425922.
    Citations: 10     Fields:    Translation:Humans
  36. Gupta S, Provenzale D, Regenbogen SE, Hampel H, Slavin TP, Hall MJ, Llor X, Chung DC, Ahnen DJ, Bray T, Cooper G, Early DS, Ford JM, Giardiello FM, Grady W, Halverson AL, Hamilton SR, Klapman JB, Larson DW, Lazenby AJ, Lynch PM, Markowitz AJ, Mayer RJ, Ness RM, Samadder NJ, Shike M, Sugandha S, Weiss JM, Dwyer MA, Ogba N. NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Colorectal, Version 3.2017. J Natl Compr Canc Netw. 2017 12; 15(12):1465-1475. PMID: 29223984.
    Citations: 51     Fields:    Translation:Humans
  37. Mashayekhi R, Bellavance DR, Chin SM, Maxner B, Staller K, Xavier RJ, Chung DC, Khalili H. Obesity, but Not Physical Activity, Is Associated With Higher Prevalence of Asymptomatic Diverticulosis. Clin Gastroenterol Hepatol. 2018 04; 16(4):586-587. PMID: 28899671; PMCID: PMC5844811.
    Citations: 4     Fields:    Translation:Humans
  38. Chung DC, McCague S, Yu ZF, Thill S, DiStefano-Pappas J, Bennett J, Cross D, Marshall K, Wellman J, High KA. Novel mobility test to assess functional vision in patients with inherited retinal dystrophies. Clin Exp Ophthalmol. 2018 04; 46(3):247-259. PMID: 28697537; PMCID: PMC5764825.
    Citations: 40     Fields:    Translation:Humans
  39. Russell S, Bennett J, Wellman JA, Chung DC, Yu ZF, Tillman A, Wittes J, Pappas J, Elci O, McCague S, Cross D, Marshall KA, Walshire J, Kehoe TL, Reichert H, Davis M, Raffini L, George LA, Hudson FP, Dingfield L, Zhu X, Haller JA, Sohn EH, Mahajan VB, Pfeifer W, Weckmann M, Johnson C, Gewaily D, Drack A, Stone E, Wachtel K, Simonelli F, Leroy BP, Wright JF, High KA, Maguire AM. Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65-mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial. Lancet. 2017 Aug 26; 390(10097):849-860. PMID: 28712537; PMCID: PMC5726391.
    Citations: 528     Fields:    Translation:HumansCTClinical Trials
  40. Drew DA, Chin SM, Gilpin KK, Parziale M, Pond E, Schuck MM, Stewart K, Flagg M, Rawlings CA, Backman V, Carolan PJ, Chung DC, Colizzo FP, Freedman M, Gala M, Garber JJ, Huttenhower C, Kedrin D, Khalili H, Kwon DS, Markowitz SD, Milne GL, Nishioka NS, Richter JM, Roy HK, Staller K, Wang M, Chan AT. ASPirin Intervention for the REDuction of colorectal cancer risk (ASPIRED): a study protocol for a randomized controlled trial. Trials. 2017 02 01; 18(1):50. PMID: 28143522.
    Citations: 21     Fields:    Translation:Humans
  41. Wu L, Fu J, Wan L, Pan J, Lai S, Zhong J, Chung DC, Wang L. Survival outcomes and surgical intervention of small intestinal neuroendocrine tumors: a population based retrospective study. Oncotarget. 2017 Jan 17; 8(3):4935-4947. PMID: 27903960.
    Citations: 10     Fields:    Translation:Humans
  42. Adar T, Rodgers LH, Shannon KM, Yoshida M, Ma T, Mattia A, Lauwers GY, Iafrate AJ, Chung DC. A tailored approach to BRAF and MLH1 methylation testing in a universal screening program for Lynch syndrome. Mod Pathol. 2017 03; 30(3):440-447. PMID: 28059100.
    Citations: 15     Fields:    Translation:HumansCellsPHPublic Health
  43. Aleman TS, Han G, Serrano LW, Fuerst NM, Charlson ES, Pearson DJ, Chung DC, Traband A, Pan W, Ying GS, Bennett J, Maguire AM, Morgan JI. Natural History of the Central Structural Abnormalities in Choroideremia: A Prospective Cross-Sectional Study. Ophthalmology. 2017 03; 124(3):359-373. PMID: 27986385.
    Citations: 43     Fields:    Translation:HumansCells
  44. Wang L, Xue M, Chung DC. c-Myc is regulated by HIF-2a in chronic hypoxia and influences sensitivity to 5-FU in colon cancer. Oncotarget. 2016 Nov 29; 7(48):78910-78917. PMID: 27793037.
    Citations: 11     Fields:    Translation:HumansCells
  45. Weingart SN, Stoffel EM, Chung DC, Sequist TD, Lederman RI, Pelletier SR, Shields HM. Delayed Workup of Rectal Bleeding in Adult Primary Care: Examining Process-of-Care Failures. Jt Comm J Qual Patient Saf. 2017 01; 43(1):32-40. PMID: 28334584.
    Citations: 8     Fields:    Translation:Humans
  46. Weingart SN, Stoffel EM, Chung DC, Sequist TD, Lederman RI, Pelletier SR, Shields HM. Working up rectal bleeding in adult primary care practices. J Eval Clin Pract. 2017 Apr; 23(2):279-287. PMID: 27436515.
    Citations: 4     Fields:    Translation:Humans
  47. Bennett J, Wellman J, Marshall KA, McCague S, Ashtari M, DiStefano-Pappas J, Elci OU, Chung DC, Sun J, Wright JF, Cross DR, Aravand P, Cyckowski LL, Bennicelli JL, Mingozzi F, Auricchio A, Pierce EA, Ruggiero J, Leroy BP, Simonelli F, High KA, Maguire AM. Safety and durability of effect of contralateral-eye administration of AAV2 gene therapy in patients with childhood-onset blindness caused by RPE65 mutations: a follow-on phase 1 trial. Lancet. 2016 Aug 13; 388(10045):661-72. PMID: 27375040; PMCID: PMC5351775.
    Citations: 167     Fields:    Translation:HumansCellsCTClinical Trials
  48. Field J, Ye DZ, Shinde M, Liu F, Schillinger KJ, Lu M, Wang T, Skettini M, Xiong Y, Brice AK, Chung DC, Patel VV. Erratum: CAP2 in cardiac conduction, sudden cardiac death and eye development. Sci Rep. 2016 05 31; 6:26640. PMID: 27244083.
    Citations:    Fields:    
  49. Goodman RP, Chung DC. Clinical Genetic Testing in Gastroenterology. Clin Transl Gastroenterol. 2016 Apr 28; 7:e167. PMID: 27124700.
    Citations:    Fields:    
  50. Garanto A, Chung DC, Duijkers L, Corral-Serrano JC, Messchaert M, Xiao R, Bennett J, Vandenberghe LH, Collin RW. In vitro and in vivo rescue of aberrant splicing in CEP290-associated LCA by antisense oligonucleotide delivery. Hum Mol Genet. 2016 06 15; 25(12):2552-2563. PMID: 27106101; PMCID: PMC6086559.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  51. Biller JA, Butros SR, Chan-Smutko G, Abrams AN, Chung DC, Hagen CE. CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 6-2016. A 10-Year-Old Boy with Abdominal Cramping and Fevers. N Engl J Med. 2016 Feb 25; 374(8):772-81. PMID: 26933852.
    Citations: 1     Fields:    Translation:HumansCells
  52. Sheth RA, Heidari P, Woods K, Chung D, Chan AT, Mahmood U. Pilot Clinical Trial of Indocyanine Green Fluorescence-Augmented Colonoscopy in High Risk Patients. Gastroenterol Res Pract. 2016; 2016:6184842. PMID: 26989406; PMCID: PMC4773548.
    Citations: 2     
  53. Field J, Ye DZ, Shinde M, Liu F, Schillinger KJ, Lu M, Wang T, Skettini M, Xiong Y, Brice AK, Chung DC, Patel VV. CAP2 in cardiac conduction, sudden cardiac death and eye development. Sci Rep. 2015 Nov 30; 5:17256. PMID: 26616005.
    Citations: 21     Fields:    Translation:Animals
  54. Pandharipande PV, Jeon A, Heberle CR, Dowling EC, Kong CY, Chung DC, Brugge WR, Hur C. Screening for Pancreatic Adenocarcinoma in BRCA2 Mutation Carriers: Results of a Disease Simulation Model. EBioMedicine. 2015 Dec; 2(12):1980-6. PMID: 26844277; PMCID: PMC4703708.
    Citations: 7     Fields:    Translation:Humans
  55. Vasireddy V, Mills JA, Gaddameedi R, Basner-Tschakarjan E, Kohnke M, Black AD, Alexandrov K, Zhou S, Maguire AM, Chung DC, Mac H, Sullivan L, Gadue P, Bennicelli JL, French DL, Bennett J. Correction: AAV-Mediated Gene Therapy for Choroideremia: Preclinical Studies in Personalized Models. PLoS One. 2015; 10(6):e0129982. PMID: 26090960.
    Citations: 1     Fields:    
  56. Chung DC. The Enigma of Carcinoids. Gastroenterology. 2015 Jul; 149(1):14-5. PMID: 26021237.
    Citations: 1     Fields:    Translation:Humans
  57. Oliveira AV, Silva GA, Chung DC. Enhancement of chitosan-mediated gene delivery through combination with phiC31 integrase. Acta Biomater. 2015 Apr; 17:89-97. PMID: 25600399.
    Citations: 4     Fields:    Translation:HumansCells
  58. Blumenthal DM, Singal G, Mangla SS, Macklin EA, Chung DC. Predicting Non-Adherence with Outpatient Colonoscopy Using a Novel Electronic Tool that Measures Prior Non-Adherence. J Gen Intern Med. 2015 Jun; 30(6):724-31. PMID: 25586869.
    Citations: 17     Fields:    Translation:Humans
  59. Richter JM, Campbell EJ, Chung DC. Interval colorectal cancer after colonoscopy. Clin Colorectal Cancer. 2015 Mar; 14(1):46-51. PMID: 25510180.
    Citations: 11     Fields:    Translation:HumansPHPublic Health
  60. Morgan JI, Han G, Klinman E, Maguire WM, Chung DC, Maguire AM, Bennett J. High-resolution adaptive optics retinal imaging of cellular structure in choroideremia. Invest Ophthalmol Vis Sci. 2014 Sep 04; 55(10):6381-97. PMID: 25190651.
    Citations: 49     Fields:    Translation:HumansCellsCTClinical Trials
  61. Black A, Vasireddy V, Chung DC, Maguire AM, Gaddameedi R, Tolmachova T, Seabra M, Bennett J. Adeno-associated virus 8-mediated gene therapy for choroideremia: preclinical studies in in vitro and in vivo models. J Gene Med. 2014 May-Jun; 16(5-6):122-30. PMID: 24962736.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  62. Arnason T, Liang WY, Alfaro E, Kelly P, Chung DC, Odze RD, Lauwers GY. Morphology and natural history of familial adenomatous polyposis-associated dysplastic fundic gland polyps. Histopathology. 2014 Sep; 65(3):353-62. PMID: 24548295.
    Citations: 15     Fields:    Translation:Humans
  63. Richter JM, Pino MS, Austin TR, Campbell E, Szymonifka J, Russo AL, Hong TS, Borger D, Iafrate AJ, Chung DC. Genetic mechanisms in interval colon cancers. Dig Dis Sci. 2014 Sep; 59(9):2255-63. PMID: 24705641.
    Citations: 9     Fields:    Translation:HumansCells
  64. Ma T, Jang EJ, Zukerberg LR, Odze R, Gala MK, Kelsey PB, Forcione DG, Brugge WR, Casey BW, Syngal S, Chung DC. Recurrences are common after endoscopic ampullectomy for adenoma in the familial adenomatous polyposis (FAP) syndrome. Surg Endosc. 2014 Aug; 28(8):2349-56. PMID: 24566750.
    Citations: 13     Fields:    Translation:Humans
  65. Gala MK, Mizukami Y, Le LP, Moriichi K, Austin T, Yamamoto M, Lauwers GY, Bardeesy N, Chung DC. Germline mutations in oncogene-induced senescence pathways are associated with multiple sessile serrated adenomas. Gastroenterology. 2014 Feb; 146(2):520-9. PMID: 24512911; PMCID: PMC3978775.
    Citations: 53     Fields:    Translation:Humans
  66. Thilly WG, Gostjeva EV, Koledova VV, Zukerberg LR, Chung D, Fomina JN, Darroudi F, Stollar BD. Metakaryotic stem cell nuclei use pangenomic dsRNA/DNA intermediates in genome replication and segregation. Organogenesis. 2014 Jan 01; 10(1):44-52. PMID: 24418910.
    Citations: 3     Fields:    Translation:HumansCells
  67. Wang L, Gala M, Yamamoto M, Pino MS, Kikuchi H, Shue DS, Shirasawa S, Austin TR, Lynch MP, Rueda BR, Zukerberg LR, Chung DC. Adrenomedullin is a therapeutic target in colorectal cancer. Int J Cancer. 2014 May 01; 134(9):2041-50. PMID: 24519534.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  68. Francis JM, Kiezun A, Ramos AH, Serra S, Pedamallu CS, Qian ZR, Banck MS, Kanwar R, Kulkarni AA, Karpathakis A, Manzo V, Contractor T, Philips J, Nickerson E, Pho N, Hooshmand SM, Brais LK, Lawrence MS, Pugh T, McKenna A, Sivachenko A, Cibulskis K, Carter SL, Ojesina AI, Freeman S, Jones RT, Voet D, Saksena G, Auclair D, Onofrio R, Shefler E, Sougnez C, Grimsby J, Green L, Lennon N, Meyer T, Caplin M, Chung DC, Beutler AS, Ogino S, Thirlwell C, Shivdasani R, Asa SL, Harris CR, Getz G, Kulke M, Meyerson M. Somatic mutation of CDKN1B in small intestine neuroendocrine tumors. Nat Genet. 2013 Dec; 45(12):1483-6. PMID: 24185511; PMCID: PMC4239432.
    Citations: 136     Fields:    Translation:Humans
  69. Glynn M, Kirby D, Chung D, Kinahan DJ, Kijanka G, Ducrée J. Centrifugo-Magnetophoretic Purification of CD4+ Cells from Whole Blood Toward Future HIV/AIDS Point-of-Care Applications. J Lab Autom. 2014 Jun; 19(3):285-96. PMID: 24056858.
    Citations: 10     Fields:    Translation:HumansCells
  70. Canver MC, Canver AC, Revere KE, Amado D, Bennett J, Chung DC. Novel mathematical algorithm for pupillometric data analysis. Comput Methods Programs Biomed. 2014; 113(1):221-5. PMID: 24129048.
    Citations: 2     Fields:    Translation:Humans
  71. Kostic AD, Chun E, Robertson L, Glickman JN, Gallini CA, Michaud M, Clancy TE, Chung DC, Lochhead P, Hold GL, El-Omar EM, Brenner D, Fuchs CS, Meyerson M, Garrett WS. Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host Microbe. 2013 Aug 14; 14(2):207-15. PMID: 23954159.
    Citations: 919     Fields:    Translation:HumansAnimalsCells
  72. Shields HM, Stoffel EM, Chung DC, Sequist TD, Li JW, Pelletier SR, Spencer J, Silk JM, Austin BL, Diguette S, Furbish JE, Lederman R, Weingart SN. Disparities in evaluation of patients with rectal bleeding 40 years and older. Clin Gastroenterol Hepatol. 2014 Apr; 12(4):669-75; quiz e33. PMID: 23891918.
    Citations: 6     Fields:    Translation:Humans
  73. Arnason T, Pino MS, Yilmaz O, Kirley SD, Rueda BR, Chung DC, Zukerberg LR. Cables1 is a tumor suppressor gene that regulates intestinal tumor progression in Apc(Min) mice. Cancer Biol Ther. 2013 Jul; 14(7):672-8. PMID: 23792637.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  74. Vasireddy V, Mills JA, Gaddameedi R, Basner-Tschakarjan E, Kohnke M, Black AD, Alexandrov K, Zhou S, Maguire AM, Chung DC, Mac H, Sullivan L, Gadue P, Bennicelli JL, French DL, Bennett J. AAV-mediated gene therapy for choroideremia: preclinical studies in personalized models. PLoS One. 2013; 8(5):e61396. PMID: 23667438.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  75. Oberg K, Casanovas O, Castaño JP, Chung D, Delle Fave G, Denèfle P, Harris P, Khan MS, Kulke MH, Scarpa A, Tang LH, Wiedenmann B. Molecular pathogenesis of neuroendocrine tumors: implications for current and future therapeutic approaches. Clin Cancer Res. 2013 Jun 01; 19(11):2842-9. PMID: 23459719.
    Citations: 26     Fields:    Translation:HumansCells
  76. Fujita H, Lennerz JK, Chung DC, Patel D, Deshpande V, Yoon SS, Lauwers GY. Endoscopic surveillance of patients with hereditary diffuse gastric cancer: biopsy recommendations after topographic distribution of cancer foci in a series of 10 CDH1-mutated gastrectomies. Am J Surg Pathol. 2012 Nov; 36(11):1709-17. PMID: 23073328.
    Citations: 18     Fields:    Translation:HumansPHPublic Health
  77. Little MW, Chung D, Boardman P, Gleeson FV, Anderson EM. Microwave ablation of pulmonary malignancies using a novel high-energy antenna system. Cardiovasc Intervent Radiol. 2013 Apr; 36(2):460-5. PMID: 22968596.
    Citations: 9     Fields:    Translation:Humans
  78. Yurgelun MB, Mercado R, Rosenblatt M, Dandapani M, Kohlmann W, Conrad P, Blanco A, Shannon KM, Chung DC, Terdiman J, Gruber SB, Garber JE, Syngal S, Stoffel EM. Impact of genetic testing on endometrial cancer risk-reducing practices in women at risk for Lynch syndrome. Gynecol Oncol. 2012 Dec; 127(3):544-51. PMID: 22940489.
    Citations: 17     Fields:    Translation:HumansCells
  79. Dhingra A, Ramakrishnan H, Neinstein A, Fina ME, Xu Y, Li J, Chung DC, Lyubarsky A, Vardi N. Gß3 is required for normal light ON responses and synaptic maintenance. J Neurosci. 2012 Aug 15; 32(33):11343-55. PMID: 22895717.
    Citations: 34     Fields:    Translation:AnimalsCells
  80. Cronin T, Chung DC, Yang Y, Nandrot EF, Bennett J. The Signalling Role of the avß5-Integrin Can Impact the Efficacy of AAV in Retinal Gene Therapy. Pharmaceuticals (Basel). 2012 May 02; 5(5):447-59. PMID: 24281556.
    Citations: 2     
  81. Shindler KS, Revere K, Dutt M, Ying GS, Chung DC. In vivo detection of experimental optic neuritis by pupillometry. Exp Eye Res. 2012 Jul; 100:1-6. PMID: 22561341.
    Citations: 15     Fields:    Translation:Animals
  82. Duerr EM, Mizukami Y, Moriichi K, Gala M, Jo WS, Kikuchi H, Xavier RJ, Chung DC. Oncogenic KRAS regulates BMP4 expression in colon cancer cell lines. Am J Physiol Gastrointest Liver Physiol. 2012 May 15; 302(10):G1223-30. PMID: 22383492.
    Citations: 4     Fields:    Translation:HumansCells
  83. Bennett J, Ashtari M, Wellman J, Marshall KA, Cyckowski LL, Chung DC, McCague S, Pierce EA, Chen Y, Bennicelli JL, Zhu X, Ying GS, Sun J, Wright JF, Auricchio A, Simonelli F, Shindler KS, Mingozzi F, High KA, Maguire AM. AAV2 gene therapy readministration in three adults with congenital blindness. Sci Transl Med. 2012 Feb 08; 4(120):120ra15. PMID: 22323828; PMCID: PMC4169122.
    Citations: 196     Fields:    Translation:HumansCellsCTClinical Trials
  84. Bennett J, Chung DC, Maguire A. Gene delivery to the retina: from mouse to man. Methods Enzymol. 2012; 507:255-74. PMID: 22365778.
    Citations: 7     Fields:    Translation:HumansAnimals
  85. Chung DC, Fogelgren B, Park KM, Heidenberg J, Zuo X, Huang L, Bennett J, Lipschutz JH. Adeno-Associated Virus-Mediated Gene Transfer to Renal Tubule Cells via a Retrograde Ureteral Approach. Nephron Extra. 2011 Jan; 1(1):217-23. PMID: 22470395.
    Citations: 12     
  86. Gala M, Chung DC. Hereditary colon cancer syndromes. Semin Oncol. 2011 Aug; 38(4):490-9. PMID: 21810508.
    Citations: 19     Fields:    Translation:Humans
  87. Pino MS, Chung DC. Microsatellite instability in the management of colorectal cancer. Expert Rev Gastroenterol Hepatol. 2011 Jun; 5(3):385-99. PMID: 21651356.
    Citations: 37     Fields:    Translation:HumansCells
  88. Ashtari M, Cyckowski LL, Monroe JF, Marshall KA, Chung DC, Auricchio A, Simonelli F, Leroy BP, Maguire AM, Shindler KS, Bennett J. The human visual cortex responds to gene therapy-mediated recovery of retinal function. J Clin Invest. 2011 Jun; 121(6):2160-8. PMID: 21606598; PMCID: PMC3104779.
    Citations: 69     Fields:    Translation:HumansCellsCTClinical Trials
  89. Blaszkowsky LS, Cusack JC, Hong TS, Chung DC, Blake MA, Lennerz JK. Case records of the Massachusetts General Hospital. Case 13-2011. A 49-year-old man with adenocarcinoma of the rectum. N Engl J Med. 2011 Apr 28; 364(17):1658-68. PMID: 21524217.
    Citations:    Fields:    Translation:Humans
  90. Mizukami Y, Kawamoto T, Sugiyama Y, Sasajima J, Koizumi K, Moriichi K, Fujiya M, Bardeesy N, Chung DC, Kohgo Y. Effect of transplantation of pro-angiogenic monocytes to pancreatic cancer-bearing mice on resistance to chemotherapy/radiotherapy. J Clin Oncol. 2011 Feb; 29(4_suppl):212. PMID: 27985919.
    Citations:    
  91. Chan AT, Baba Y, Shima K, Nosho K, Chung DC, Hung KE, Mahmood U, Madden K, Poss K, Ranieri A, Shue D, Kucherlapati R, Fuchs CS, Ogino S. Cathepsin B expression and survival in colon cancer: implications for molecular detection of neoplasia. Cancer Epidemiol Biomarkers Prev. 2010 Nov; 19(11):2777-85. PMID: 20833970.
    Citations: 24     Fields:    Translation:Humans
  92. Chung DC. Molecular biology of neuroendocrine tumours. Regul Pept. 2010 Sep 9; 164(1):3-4. PMID: 26009325.
    Citations:    
  93. Pandalai PK, Lauwers GY, Chung DC, Patel D, Yoon SS. Prophylactic total gastrectomy for individuals with germline CDH1 mutation. Surgery. 2011 Mar; 149(3):347-55. PMID: 20719348.
    Citations: 24     Fields:    Translation:Humans
  94. Willett CG, Duda DG, Ancukiewicz M, Shah M, Czito BG, Bentley R, Poleski M, Fujita H, Lauwers GY, Carroll M, Tyler D, Mantyh C, Shellito P, Chung DC, Clark JW, Jain RK. A safety and survival analysis of neoadjuvant bevacizumab with standard chemoradiation in a phase I/II study compared with standard chemoradiation in locally advanced rectal cancer. Oncologist. 2010; 15(8):845-51. PMID: 20667969.
    Citations: 28     Fields:    Translation:HumansCTClinical Trials
  95. Sasajima J, Mizukami Y, Sugiyama Y, Nakamura K, Kawamoto T, Koizumi K, Fujii R, Motomura W, Sato K, Suzuki Y, Tanno S, Fujiya M, Sasaki K, Shimizu N, Karasaki H, Kono T, Kawabe J, Ii M, Yoshiara H, Kamiyama N, Ashida T, Bardeesy N, Chung DC, Kohgo Y. Transplanting normal vascular proangiogenic cells to tumor-bearing mice triggers vascular remodeling and reduces hypoxia in tumors. Cancer Res. 2010 Aug 01; 70(15):6283-92. PMID: 20631070.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  96. Grafals M, Kamal L, Chung D, Abdi R. Gene polymorphisms in renal transplantation. Semin Nephrol. 2010 Jul; 30(4):418-25. PMID: 20807614.
    Citations:    Fields:    Translation:Humans
  97. Fitzgerald RC, Hardwick R, Huntsman D, Carneiro F, Guilford P, Blair V, Chung DC, Norton J, Ragunath K, Van Krieken JH, Dwerryhouse S, Caldas C. Hereditary diffuse gastric cancer: updated consensus guidelines for clinical management and directions for future research. J Med Genet. 2010 Jul; 47(7):436-44. PMID: 20591882.
    Citations: 189     Fields:    Translation:Humans
  98. Pino MS, Chung DC. Application of molecular diagnostics for the detection of Lynch syndrome. Expert Rev Mol Diagn. 2010 Jul; 10(5):651-65. PMID: 20629513.
    Citations: 11     Fields:    Translation:Humans
  99. Jang E, Chung DC. Hereditary colon cancer: lynch syndrome. Gut Liver. 2010 Jun; 4(2):151-60. PMID: 20559516.
    Citations: 17     Fields:    
  100. Zeng M, Kikuchi H, Pino MS, Chung DC. Hypoxia activates the K-ras proto-oncogene to stimulate angiogenesis and inhibit apoptosis in colon cancer cells. PLoS One. 2010 Jun 04; 5(6):e10966. PMID: 20532039; PMCID: PMC2881039.
    Citations: 26     Fields:    Translation:HumansCells
  101. Pino MS, Chung DC. The chromosomal instability pathway in colon cancer. Gastroenterology. 2010 Jun; 138(6):2059-72. PMID: 20420946; PMCID: PMC4243705.
    Citations: 326     Fields:    Translation:HumansAnimalsCells
  102. Baba Y, Nosho K, Shima K, Irahara N, Chan AT, Meyerhardt JA, Chung DC, Giovannucci EL, Fuchs CS, Ogino S. HIF1A overexpression is associated with poor prognosis in a cohort of 731 colorectal cancers. Am J Pathol. 2010 May; 176(5):2292-301. PMID: 20363910; PMCID: PMC2861094.
    Citations: 122     Fields:    Translation:HumansCells
  103. Stoffel EM, Mercado RC, Kohlmann W, Ford B, Grover S, Conrad P, Blanco A, Shannon KM, Powell M, Chung DC, Terdiman J, Gruber SB, Syngal S. Prevalence and predictors of appropriate colorectal cancer surveillance in Lynch syndrome. Am J Gastroenterol. 2010 Aug; 105(8):1851-60. PMID: 20354509.
    Citations: 36     Fields:    Translation:HumansPHPublic Health
  104. Hirota SA, Fines K, Ng J, Traboulsi D, Lee J, Ihara E, Li Y, Willmore WG, Chung D, Scully MM, Louie T, Medlicott S, Lejeune M, Chadee K, Armstrong G, Colgan SP, Muruve DA, MacDonald JA, Beck PL. Hypoxia-inducible factor signaling provides protection in Clostridium difficile-induced intestinal injury. Gastroenterology. 2010 Jul; 139(1):259-69.e3. PMID: 20347817; PMCID: PMC3063899.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  105. Manne SL, Meropol NJ, Weinberg DS, Vig H, Ali-Khan Catts Z, Manning C, Ross E, Shannon K, Chung DC. Facilitating informed decisions regarding microsatellite instability testing among high-risk individuals diagnosed with colorectal cancer. J Clin Oncol. 2010 Mar 10; 28(8):1366-72. PMID: 20142594.
    Citations: 20     Fields:    Translation:Humans
  106. Nakamura K, Sasajima J, Mizukami Y, Sugiyama Y, Yamazaki M, Fujii R, Kawamoto T, Koizumi K, Sato K, Fujiya M, Sasaki K, Tanno S, Okumura T, Shimizu N, Kawabe J, Karasaki H, Kono T, Ii M, Bardeesy N, Chung DC, Kohgo Y. Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells. PLoS One. 2010 Jan 21; 5(1):e8824. PMID: 20098680.
    Citations: 39     Fields:    Translation:AnimalsCells
  107. Park KM, Fogelgren B, Zuo X, Kim J, Chung DC, Lipschutz JH. Exocyst Sec10 protects epithelial barrier integrity and enhances recovery following oxidative stress, by activation of the MAPK pathway. Am J Physiol Renal Physiol. 2010 Mar; 298(3):F818-26. PMID: 20053792.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  108. Pino MS, Kikuchi H, Zeng M, Herraiz MT, Sperduti I, Berger D, Park DY, Iafrate AJ, Zukerberg LR, Chung DC. Epithelial to mesenchymal transition is impaired in colon cancer cells with microsatellite instability. Gastroenterology. 2010 Apr; 138(4):1406-17. PMID: 20026115; PMCID: PMC2846966.
    Citations: 64     Fields:    Translation:HumansCells
  109. Chung DC, Traboulsi EI. Leber congenital amaurosis: clinical correlations with genotypes, gene therapy trials update, and future directions. J AAPOS. 2009 Dec; 13(6):587-92. PMID: 20006823.
    Citations: 44     Fields:    Translation:Humans
  110. Maguire AM, High KA, Auricchio A, Wright JF, Pierce EA, Testa F, Mingozzi F, Bennicelli JL, Ying GS, Rossi S, Fulton A, Marshall KA, Banfi S, Chung DC, Morgan JI, Hauck B, Zelenaia O, Zhu X, Raffini L, Coppieters F, De Baere E, Shindler KS, Volpe NJ, Surace EM, Acerra C, Lyubarsky A, Redmond TM, Stone E, Sun J, McDonnell JW, Leroy BP, Simonelli F, Bennett J. Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial. Lancet. 2009 Nov 07; 374(9701):1597-605. PMID: 19854499; PMCID: PMC4492302.
    Citations: 384     Fields:    Translation:HumansCellsCTClinical Trials
  111. Kikuchi H, Pino MS, Zeng M, Shirasawa S, Chung DC. Oncogenic KRAS and BRAF differentially regulate hypoxia-inducible factor-1alpha and -2alpha in colon cancer. Cancer Res. 2009 Nov 01; 69(21):8499-506. PMID: 19843849.
    Citations: 47     Fields:    Translation:HumansCells
  112. Xu L, Duda DG, di Tomaso E, Ancukiewicz M, Chung DC, Lauwers GY, Samuel R, Shellito P, Czito BG, Lin PC, Poleski M, Bentley R, Clark JW, Willett CG, Jain RK. Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer. Cancer Res. 2009 Oct 15; 69(20):7905-10. PMID: 19826039.
    Citations: 74     Fields:    Translation:HumansCells
  113. Revere KE, Chung DC. Recent breakthroughs in gene therapy for inherited retinal degeneration. Discov Med. 2009 Oct; 8(42):125-9. PMID: 19833058.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  114. Greenblatt WH, Hur C, Knudsen AB, Evans JA, Chung DC, Gazelle GS. Cost-effectiveness of prophylactic surgery for duodenal cancer in familial adenomatous polyposis. Cancer Epidemiol Biomarkers Prev. 2009 Oct; 18(10):2677-84. PMID: 19789369.
    Citations:    Fields:    Translation:Humans
  115. Chung DC, Lee V, Maguire AM. Recent advances in ocular gene therapy. Curr Opin Ophthalmol. 2009 Sep; 20(5):377-81. PMID: 19667988.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  116. Grover S, Stoffel EM, Mercado RC, Ford BM, Kohlman WK, Shannon KM, Conrad PG, Blanco AM, Terdiman JP, Gruber SB, Chung DC, Syngal S. Colorectal cancer risk perception on the basis of genetic test results in individuals at risk for Lynch syndrome. J Clin Oncol. 2009 Aug 20; 27(24):3981-6. PMID: 19620492.
    Citations: 13     Fields:    Translation:HumansCells
  117. Benita Y, Kikuchi H, Smith AD, Zhang MQ, Chung DC, Xavier RJ. An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia. Nucleic Acids Res. 2009 Aug; 37(14):4587-602. PMID: 19491311.
    Citations: 236     Fields:    Translation:HumansCells
  118. Willett CG, Duda DG, di Tomaso E, Boucher Y, Ancukiewicz M, Sahani DV, Lahdenranta J, Chung DC, Fischman AJ, Lauwers GY, Shellito P, Czito BG, Wong TZ, Paulson E, Poleski M, Vujaskovic Z, Bentley R, Chen HX, Clark JW, Jain RK. Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study. J Clin Oncol. 2009 Jun 20; 27(18):3020-6. PMID: 19470921.
    Citations: 214     Fields:    Translation:HumansCellsCTClinical Trials
  119. Bertagnolli MM, Eagle CJ, Zauber AG, Redston M, Breazna A, Kim K, Tang J, Rosenstein RB, Umar A, Bagheri D, Collins NT, Burn J, Chung DC, Dewar T, Foley TR, Hoffman N, Macrae F, Pruitt RE, Saltzman JR, Salzberg B, Sylwestrowicz T, Hawk ET. Five-year efficacy and safety analysis of the Adenoma Prevention with Celecoxib Trial. Cancer Prev Res (Phila). 2009 Apr; 2(4):310-21. PMID: 19336730.
    Citations: 89     Fields:    Translation:Humans
  120. Pino MS, Mino-Kenudson M, Wildemore BM, Ganguly A, Batten J, Sperduti I, Iafrate AJ, Chung DC. Deficient DNA mismatch repair is common in Lynch syndrome-associated colorectal adenomas. J Mol Diagn. 2009 May; 11(3):238-47. PMID: 19324997.
    Citations: 33     Fields:    Translation:HumansCells
  121. Imamura T, Kikuchi H, Herraiz MT, Park DY, Mizukami Y, Mino-Kenduson M, Lynch MP, Rueda BR, Benita Y, Xavier RJ, Chung DC. HIF-1alpha and HIF-2alpha have divergent roles in colon cancer. Int J Cancer. 2009 Feb 15; 124(4):763-71. PMID: 19030186.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  122. Chung DC. Stool DNA testing and colon cancer prevention: another step forward. Ann Intern Med. 2008 Oct 07; 149(7):509-10. PMID: 18838731.
    Citations: 5     Fields:    Translation:Humans
  123. Modlin IM, Moss SF, Chung DC, Jensen RT, Snyderwine E. Priorities for improving the management of gastroenteropancreatic neuroendocrine tumors. J Natl Cancer Inst. 2008 Sep 17; 100(18):1282-9. PMID: 18780869.
    Citations: 92     Fields:    Translation:HumansAnimals
  124. Fujiki K, Duerr EM, Kikuchi H, Ng A, Xavier RJ, Mizukami Y, Imamura T, Kulke MH, Chung DC. Hoxc6 is overexpressed in gastrointestinal carcinoids and interacts with JunD to regulate tumor growth. Gastroenterology. 2008 Sep; 135(3):907-16, 916.e1-2. PMID: 18655788; PMCID: PMC3777410.
    Citations: 11     Fields:    Translation:HumansCells
  125. Hernandez JC, Reicher S, Chung D, Pham BV, Tsai F, Disibio G, French S, Eysselein VE. Pilot series of radiofrequency ablation of Barrett's esophagus with or without neoplasia. Endoscopy. 2008 May; 40(5):388-92. PMID: 18459075.
    Citations: 13     Fields:    Translation:Humans
  126. Yamazaki M, Nakamura K, Mizukami Y, Ii M, Sasajima J, Sugiyama Y, Nishikawa T, Nakano Y, Yanagawa N, Sato K, Maemoto A, Tanno S, Okumura T, Karasaki H, Kono T, Fujiya M, Ashida T, Chung DC, Kohgo Y. Sonic hedgehog derived from human pancreatic cancer cells augments angiogenic function of endothelial progenitor cells. Cancer Sci. 2008 Jun; 99(6):1131-8. PMID: 18422746.
    Citations: 26     Fields:    Translation:HumansCells
  127. Duerr EM, Mizukami Y, Ng A, Xavier RJ, Kikuchi H, Deshpande V, Warshaw AL, Glickman J, Kulke MH, Chung DC. Defining molecular classifications and targets in gastroenteropancreatic neuroendocrine tumors through DNA microarray analysis. Endocr Relat Cancer. 2008 Mar; 15(1):243-56. PMID: 18310291.
    Citations: 34     Fields:    Translation:Humans
  128. Stoffel EM, Ford B, Mercado RC, Punglia D, Kohlmann W, Conrad P, Blanco A, Shannon KM, Powell M, Gruber SB, Terdiman J, Chung DC, Syngal S. Sharing genetic test results in Lynch syndrome: communication with close and distant relatives. Clin Gastroenterol Hepatol. 2008 Mar; 6(3):333-8. PMID: 18258490.
    Citations: 52     Fields:    Translation:Humans
  129. Bennicelli J, Wright JF, Komaromy A, Jacobs JB, Hauck B, Zelenaia O, Mingozzi F, Hui D, Chung D, Rex TS, Wei Z, Qu G, Zhou S, Zeiss C, Arruda VR, Acland GM, Dell'Osso LF, High KA, Maguire AM, Bennett J. Reversal of blindness in animal models of leber congenital amaurosis using optimized AAV2-mediated gene transfer. Mol Ther. 2008 Mar; 16(3):458-65. PMID: 18209734.
    Citations: 117     Fields:    Translation:AnimalsCells
  130. Modlin IM, Oberg K, Chung DC, Jensen RT, de Herder WW, Thakker RV, Caplin M, Delle Fave G, Kaltsas GA, Krenning EP, Moss SF, Nilsson O, Rindi G, Salazar R, Ruszniewski P, Sundin A. Gastroenteropancreatic neuroendocrine tumours. Lancet Oncol. 2008 Jan; 9(1):61-72. PMID: 18177818.
    Citations: 540     Fields:    Translation:HumansAnimals
  131. Sakamoto H, Friel AM, Wood AW, Guo L, Ilic A, Seiden MV, Chung DC, Lynch MP, Serikawa T, Munro E, Oliva E, Orsulic S, Kirley SD, Foster R, Zukerberg LR, Rueda BR. Mechanisms of Cables 1 gene inactivation in human ovarian cancer development. Cancer Biol Ther. 2008 Feb; 7(2):180-88. PMID: 18059193.
    Citations: 11     Fields:    Translation:HumansCells
  132. Park DY, Sakamoto H, Kirley SD, Ogino S, Kawasaki T, Kwon E, Mino-Kenudson M, Lauwers GY, Chung DC, Rueda BR, Zukerberg LR. The Cables gene on chromosome 18q is silenced by promoter hypermethylation and allelic loss in human colorectal cancer. Am J Pathol. 2007 Nov; 171(5):1509-19. PMID: 17982127; PMCID: PMC2043512.
    Citations: 18     Fields:    Translation:HumansCells
  133. Manne SL, Chung DC, Weinberg DS, Vig HS, Catts Z, Cabral MK, Shannon K, Meropol NJ. Knowledge and attitudes about microsatellite instability testing among high-risk individuals diagnosed with colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2007 Oct; 16(10):2110-7. PMID: 17932359.
    Citations: 14     Fields:    Translation:Humans
  134. Mizukami Y, Kohgo Y, Chung DC. Hypoxia inducible factor-1 independent pathways in tumor angiogenesis. Clin Cancer Res. 2007 Oct 01; 13(19):5670-4. PMID: 17908955.
    Citations: 73     Fields:    Translation:HumansCells
  135. Chung D, Ghossein RA, Lin O. Macrofollicular variant of papillary carcinoma: a potential thyroid FNA pitfall. Diagn Cytopathol. 2007 Sep; 35(9):560-4. PMID: 17703452.
    Citations: 6     Fields:    Translation:Humans
  136. Choi MY, Lauwers GY, Hur C, Willett CG, Chung DC. Microsatellite instability is frequently observed in rectal cancer and influenced by neoadjuvant chemoradiation. Int J Radiat Oncol Biol Phys. 2007 Aug 01; 68(5):1584. PMID: 17674996.
    Citations: 7     Fields:    Translation:Humans
  137. Chung DC, Yoon SS, Lauwers GY, Patel D. Case records of the Massachusetts General Hospital. Case 22-2007. A woman with a family history of gastric and breast cancer. N Engl J Med. 2007 Jul 19; 357(3):283-91. PMID: 17634464.
    Citations: 13     Fields:    Translation:Humans
  138. Kaurah P, MacMillan A, Boyd N, Senz J, De Luca A, Chun N, Suriano G, Zaor S, Van Manen L, Gilpin C, Nikkel S, Connolly-Wilson M, Weissman S, Rubinstein WS, Sebold C, Greenstein R, Stroop J, Yim D, Panzini B, McKinnon W, Greenblatt M, Wirtzfeld D, Fontaine D, Coit D, Yoon S, Chung D, Lauwers G, Pizzuti A, Vaccaro C, Redal MA, Oliveira C, Tischkowitz M, Olschwang S, Gallinger S, Lynch H, Green J, Ford J, Pharoah P, Fernandez B, Huntsman D. Founder and recurrent CDH1 mutations in families with hereditary diffuse gastric cancer. JAMA. 2007 Jun 06; 297(21):2360-72. PMID: 17545690.
    Citations: 155     Fields:    Translation:Humans
  139. Duerr EM, Chung DC. Molecular genetics of neuroendocrine tumors. Best Pract Res Clin Endocrinol Metab. 2007 Mar; 21(1):1-14. PMID: 17382262.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  140. Ruszniewski P, Delle Fave G, Cadiot G, Komminoth P, Chung D, Kos-Kudla B, Kianmanesh R, Hochhauser D, Arnold R, Ahlman H, Pauwels S, Kwekkeboom DJ, Rindi G. Well-differentiated gastric tumors/carcinomas. Neuroendocrinology. 2006; 84(3):158-64. PMID: 17312375.
    Citations: 36     Fields:    Translation:Humans
  141. Hur C, Chung DC, Schoen RE, Gazelle GS. The management of small polyps found by virtual colonoscopy: results of a decision analysis. Clin Gastroenterol Hepatol. 2007 Feb; 5(2):237-44. PMID: 17296532.
    Citations: 12     Fields:    Translation:Humans
  142. Herraiz M, Barbesino G, Faquin W, Chan-Smutko G, Patel D, Shannon KM, Daniels GH, Chung DC. Prevalence of thyroid cancer in familial adenomatous polyposis syndrome and the role of screening ultrasound examinations. Clin Gastroenterol Hepatol. 2007 Mar; 5(3):367-73. PMID: 17258512.
    Citations: 27     Fields:    Translation:HumansPHPublic Health
  143. Endo M, Zoltick PW, Chung DC, Bennett J, Radu A, Muvarak N, Flake AW. Gene transfer to ocular stem cells by early gestational intraamniotic injection of lentiviral vector. Mol Ther. 2007 Mar; 15(3):579-87. PMID: 17245352.
    Citations: 24     Fields:    Translation:AnimalsCells
  144. O'Keefe SJ, Chung D, Mahmoud N, Sepulveda AR, Manafe M, Arch J, Adada H, van der Merwe T. Why do African Americans get more colon cancer than Native Africans? J Nutr. 2007 01; 137(1 Suppl):175S-182S. PMID: 17182822.
    Citations: 76     Fields:    Translation:HumansCells
  145. Kwak EL, Chung DC. Hereditary colorectal cancer syndromes: an overview. Clin Colorectal Cancer. 2007 Jan; 6(5):340-4. PMID: 17311698.
    Citations: 11     Fields:    Translation:Humans
  146. Chung DC, Maher MM, Faquin WC. Case records of the Massachusetts General Hospital. Case 37-2006. A 19-year-old woman with thyroid cancer and lower gastrointestinal bleeding. N Engl J Med. 2006 Nov 30; 355(22):2349-57. PMID: 17135589.
    Citations: 3     Fields:    Translation:Humans
  147. Lauwers GY, Chung DC. The serrated polyp comes of age. Gastroenterology. 2006 Nov; 131(5):1631-4. PMID: 17067594.
    Citations: 2     Fields:    Translation:Humans
  148. Bertagnolli MM, Eagle CJ, Zauber AG, Redston M, Solomon SD, Kim K, Tang J, Rosenstein RB, Wittes J, Corle D, Hess TM, Woloj GM, Boisserie F, Anderson WF, Viner JL, Bagheri D, Burn J, Chung DC, Dewar T, Foley TR, Hoffman N, Macrae F, Pruitt RE, Saltzman JR, Salzberg B, Sylwestrowicz T, Gordon GB, Hawk ET. Celecoxib for the prevention of sporadic colorectal adenomas. N Engl J Med. 2006 Aug 31; 355(9):873-84. PMID: 16943400.
    Citations: 389     Fields:    Translation:HumansPHPublic Health
  149. Melamud A, Shen GQ, Chung D, Xi Q, Simpson E, Li L, Peachey NS, Zegarra H, Hagstrom SA, Wang QK, Traboulsi EI. Mapping a new genetic locus for X linked retinitis pigmentosa to Xq28. J Med Genet. 2006 Jun; 43(6):e27. PMID: 16740911; PMCID: PMC2593026.
    Citations: 10     Fields:    Translation:HumansCells
  150. Bidinost C, Matsumoto M, Chung D, Salem N, Zhang K, Stockton DW, Khoury A, Megarbane A, Bejjani BA, Traboulsi EI. Heterozygous and homozygous mutations in PITX3 in a large Lebanese family with posterior polar cataracts and neurodevelopmental abnormalities. Invest Ophthalmol Vis Sci. 2006 Apr; 47(4):1274-80. PMID: 16565358.
    Citations: 29     Fields:    Translation:HumansCells
  151. Mizukami Y, Fujiki K, Duerr EM, Gala M, Jo WS, Zhang X, Chung DC. Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-kinase/Rho/ROCK and c-Myc. J Biol Chem. 2006 May 19; 281(20):13957-63. PMID: 16543245.
    Citations: 41     Fields:    Translation:HumansCells
  152. Hung KE, Chung DC. Colorectal cancer screening: today and tomorrow. South Med J. 2006 Mar; 99(3):240-6; quiz 247-9. PMID: 16553098.
    Citations: 3     Fields:    Translation:HumansPHPublic Health
  153. Syngal S, Stoffel E, Chung D, Willett C, Schoetz D, Schroy P, Jagadeesh D, Morel K, Ross M. Detection of stool DNA mutations before and after treatment of colorectal neoplasia. Cancer. 2006 Jan 15; 106(2):277-83. PMID: 16342248.
    Citations: 14     Fields:    Translation:Humans
  154. Gostjeva EV, Zukerberg L, Chung D, Thilly WG. Bell-shaped nuclei dividing by symmetrical and asymmetrical nuclear fission have qualities of stem cells in human colonic embryogenesis and carcinogenesis. Cancer Genet Cytogenet. 2006 Jan 01; 164(1):16-24. PMID: 16364758.
    Citations: 10     Fields:    Translation:HumansCells
  155. Hung KE, Chung DC. New insights into the molecular pathogenesis of colorectal cancer. Drug Discov Today Dis Mech. 2006; 3(4):439. PMID: 20151020.
    Citations: 3     
  156. Jo WS, Mizukami Y, Duerr EM, Zukerberg LR, Chung DC. Wnt signaling can repress thrombospondin-1 expression in colonic tumorigenesis. Cancer Biol Ther. 2005 Dec; 4(12):1361-6. PMID: 16258261.
    Citations: 11     Fields:    Translation:HumansCells
  157. Willett CG, Boucher Y, Duda DG, di Tomaso E, Munn LL, Tong RT, Kozin SV, Petit L, Jain RK, Chung DC, Sahani DV, Kalva SP, Cohen KS, Scadden DT, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Shellito PC, Mino-Kenudson M, Lauwers GY. Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients. J Clin Oncol. 2005 Nov 01; 23(31):8136-9. PMID: 16258121.
    Citations: 156     Fields:    Translation:HumansCTClinical Trials
  158. Korzenik J, Chung DC, Digumarthy S, Badizadegan K. Case records of the Massachusetts General Hospital. Case 33-2005. A 43-year-old man with lower gastrointestinal bleeding. N Engl J Med. 2005 Oct 27; 353(17):1836-44. PMID: 16251540.
    Citations: 1     Fields:    Translation:Humans
  159. Jo WS, Bandipalliam P, Shannon KM, Niendorf KB, Chan-Smutko G, Hur C, Syngal S, Chung DC. Correlation of polyp number and family history of colon cancer with germline MYH mutations. Clin Gastroenterol Hepatol. 2005 Oct; 3(10):1022-8. PMID: 16234049.
    Citations: 12     Fields:    Translation:Humans
  160. Mizukami Y, Jo WS, Duerr EM, Gala M, Li J, Zhang X, Zimmer MA, Iliopoulos O, Zukerberg LR, Kohgo Y, Lynch MP, Rueda BR, Chung DC. Induction of interleukin-8 preserves the angiogenic response in HIF-1alpha-deficient colon cancer cells. Nat Med. 2005 Sep; 11(9):992-7. PMID: 16127434.
    Citations: 185     Fields:    Translation:HumansAnimalsCells
  161. Kirley SD, D'Apuzzo M, Lauwers GY, Graeme-Cook F, Chung DC, Zukerberg LR. The Cables gene on chromosome 18Q regulates colon cancer progression in vivo. Cancer Biol Ther. 2005 Aug; 4(8):861-3. PMID: 16210915.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  162. Kirley SD, Rueda BR, Chung DC, Zukerberg LR. Increased growth rate, delayed senescense and decreased serum dependence characterize cables-deficient cells. Cancer Biol Ther. 2005 Jun; 4(6):654-8. PMID: 15908791.</