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profileDaniel C. Chung, M.D.

TitleAssociate Professor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
Gastrointestinal Unit, GRJ 825
50 Blossom St
Boston MA 02114
Phone617/726-3766
Fax617/643-0195
vCardDownload vCard (login for email)

Collapse Mentoring 
Collapse completed student projects
The role of Egr-1 in the HIF-1-independent regulation of VEGF in colon cancer
Summer, 06/13/04 - 08/20/04

Collapse Research 
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01CA092594     (CHUNG, DANIEL C)Jul 1, 2001 - Mar 31, 2013
NIH/NCI
Genetic Regulation of Angiogenesis in Colonic Polyps
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Mashayekhi R, Bellavance DR, Chin SM, Maxner B, Staller K, Xavier RJ, Chung DC, Khalili H. Obesity, but Not Physical Activity, Is Associated With Higher Prevalence of Asymptomatic Diverticulosis. Clin Gastroenterol Hepatol. 2017 Sep 09. PMID: 28899671.
    View in: PubMed
  2. Russell S, Bennett J, Wellman JA, Chung DC, Yu ZF, Tillman A, Wittes J, Pappas J, Elci O, McCague S, Cross D, Marshall KA, Walshire J, Kehoe TL, Reichert H, Davis M, Raffini L, George LA, Hudson FP, Dingfield L, Zhu X, Haller JA, Sohn EH, Mahajan VB, Pfeifer W, Weckmann M, Johnson C, Gewaily D, Drack A, Stone E, Wachtel K, Simonelli F, Leroy BP, Wright JF, High KA, Maguire AM. Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65-mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial. Lancet. 2017 Aug 26; 390(10097):849-860. PMID: 28712537.
    View in: PubMed
  3. Chung DC, McCague S, Yu ZF, Thill S, DiStefano-Pappas J, Bennett J, Cross D, Marshall K, Wellman J, High KA. Novel mobility test to assess functional vision in patients with inherited retinal dystrophies. Clin Exp Ophthalmol. 2017 Jul 11. PMID: 28697537.
    View in: PubMed
  4. Drew DA, Chin SM, Gilpin KK, Parziale M, Pond E, Schuck MM, Stewart K, Flagg M, Rawlings CA, Backman V, Carolan PJ, Chung DC, Colizzo FP, Freedman M, Gala M, Garber JJ, Huttenhower C, Kedrin D, Khalili H, Kwon DS, Markowitz SD, Milne GL, Nishioka NS, Richter JM, Roy HK, Staller K, Wang M, Chan AT. ASPirin Intervention for the REDuction of colorectal cancer risk (ASPIRED): a study protocol for a randomized controlled trial. Trials. 2017 Feb 01; 18(1):50. PMID: 28143522.
    View in: PubMed
  5. Wu L, Fu J, Wan L, Pan J, Lai S, Zhong J, Chung DC, Wang L. Survival outcomes and surgical intervention of small intestinal neuroendocrine tumors: a population based retrospective study. Oncotarget. 2017 Jan 17; 8(3):4935-4947. PMID: 27903960.
    View in: PubMed
  6. Adar T, Rodgers LH, Shannon KM, Yoshida M, Ma T, Mattia A, Lauwers GY, Iafrate AJ, Chung DC. A tailored approach to BRAF and MLH1 methylation testing in a universal screening program for Lynch syndrome. Mod Pathol. 2017 Mar; 30(3):440-447. PMID: 28059100.
    View in: PubMed
  7. Aleman TS, Han G, Serrano LW, Fuerst NM, Charlson ES, Pearson DJ, Chung DC, Traband A, Pan W, Ying GS, Bennett J, Maguire AM, Morgan JI. Natural History of the Central Structural Abnormalities in Choroideremia: A Prospective Cross-Sectional Study. Ophthalmology. 2017 Mar; 124(3):359-373. PMID: 27986385.
    View in: PubMed
  8. Wang L, Xue M, Chung DC. c-Myc is regulated by HIF-2a in chronic hypoxia and influences sensitivity to 5-FU in colon cancer. Oncotarget. 2016 Nov 29; 7(48):78910-78917. PMID: 27793037.
    View in: PubMed
  9. Weingart SN, Stoffel EM, Chung DC, Sequist TD, Lederman RI, Pelletier SR, Shields HM. Delayed Workup of Rectal Bleeding in Adult Primary Care: Examining Process-of-Care Failures. Jt Comm J Qual Patient Saf. 2017 Jan; 43(1):32-40. PMID: 28334584.
    View in: PubMed
  10. Weingart SN, Stoffel EM, Chung DC, Sequist TD, Lederman RI, Pelletier SR, Shields HM. Working up rectal bleeding in adult primary care practices. J Eval Clin Pract. 2017 Apr; 23(2):279-287. PMID: 27436515.
    View in: PubMed
  11. Bennett J, Wellman J, Marshall KA, McCague S, Ashtari M, DiStefano-Pappas J, Elci OU, Chung DC, Sun J, Wright JF, Cross DR, Aravand P, Cyckowski LL, Bennicelli JL, Mingozzi F, Auricchio A, Pierce EA, Ruggiero J, Leroy BP, Simonelli F, High KA, Maguire AM. Safety and durability of effect of contralateral-eye administration of AAV2 gene therapy in patients with childhood-onset blindness caused by RPE65 mutations: a follow-on phase 1 trial. Lancet. 2016 Aug 13; 388(10045):661-72. PMID: 27375040.
    View in: PubMed
  12. Field J, Ye DZ, Shinde M, Liu F, Schillinger KJ, Lu M, Wang T, Skettini M, Xiong Y, Brice AK, Chung DC, Patel VV. Erratum: CAP2 in cardiac conduction, sudden cardiac death and eye development. Sci Rep. 2016 May 31; 6:26640. PMID: 27244083; PMCID: PMC4886578.
  13. Goodman RP, Chung DC. Clinical Genetic Testing in Gastroenterology. Clin Transl Gastroenterol. 2016 Apr 28; 7:e167. PMID: 27124700; PMCID: PMC4855164.
  14. Garanto A, Chung DC, Duijkers L, Corral-Serrano JC, Messchaert M, Xiao R, Bennett J, Vandenberghe LH, Collin RW. In vitro and in vivo rescue of aberrant splicing in CEP290-associated LCA by antisense oligonucleotide delivery. Hum Mol Genet. 2016 Jun 15; 25(12):2552-2563. PMID: 27106101.
    View in: PubMed
  15. Biller JA, Butros SR, Chan-Smutko G, Abrams AN, Chung DC, Hagen CE. CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 6-2016. A 10-Year-Old Boy with Abdominal Cramping and Fevers. N Engl J Med. 2016 Feb 25; 374(8):772-81. PMID: 26933852.
    View in: PubMed
  16. Sheth RA, Heidari P, Woods K, Chung D, Chan AT, Mahmood U. Pilot Clinical Trial of Indocyanine Green Fluorescence-Augmented Colonoscopy in High Risk Patients. Gastroenterol Res Pract. 2016; 2016:6184842. PMID: 26989406; PMCID: PMC4773548.
  17. Field J, Ye DZ, Shinde M, Liu F, Schillinger KJ, Lu M, Wang T, Skettini M, Xiong Y, Brice AK, Chung DC, Patel VV. CAP2 in cardiac conduction, sudden cardiac death and eye development. Sci Rep. 2015 Nov 30; 5:17256. PMID: 26616005; PMCID: PMC4663486.
  18. Pandharipande PV, Jeon A, Heberle CR, Dowling EC, Kong CY, Chung DC, Brugge WR, Hur C. Screening for Pancreatic Adenocarcinoma in BRCA2 Mutation Carriers: Results of a Disease Simulation Model. EBioMedicine. 2015 Dec; 2(12):1980-6. PMID: 26844277; PMCID: PMC4703708.
  19. Vasireddy V, Mills JA, Gaddameedi R, Basner-Tschakarjan E, Kohnke M, Black AD, Alexandrov K, Zhou S, Maguire AM, Chung DC, Mac H, Sullivan L, Gadue P, Bennicelli JL, French DL, Bennett J. Correction: AAV-Mediated Gene Therapy for Choroideremia: Preclinical Studies in Personalized Models. PLoS One. 2015; 10(6):e0129982. PMID: 26090960; PMCID: PMC4474960.
  20. Chung DC. The Enigma of Carcinoids. Gastroenterology. 2015 Jul; 149(1):14-5. PMID: 26021237.
    View in: PubMed
  21. Oliveira AV, Silva GA, Chung DC. Enhancement of chitosan-mediated gene delivery through combination with phiC31 integrase. Acta Biomater. 2015 Apr; 17:89-97. PMID: 25600399.
    View in: PubMed
  22. Blumenthal DM, Singal G, Mangla SS, Macklin EA, Chung DC. Predicting Non-Adherence with Outpatient Colonoscopy Using a Novel Electronic Tool that Measures Prior Non-Adherence. J Gen Intern Med. 2015 Jun; 30(6):724-31. PMID: 25586869; PMCID: PMC4441666.
  23. Richter JM, Campbell EJ, Chung DC. Interval colorectal cancer after colonoscopy. Clin Colorectal Cancer. 2015 Mar; 14(1):46-51. PMID: 25510180.
    View in: PubMed
  24. Morgan JI, Han G, Klinman E, Maguire WM, Chung DC, Maguire AM, Bennett J. High-resolution adaptive optics retinal imaging of cellular structure in choroideremia. Invest Ophthalmol Vis Sci. 2014 Sep 04; 55(10):6381-97. PMID: 25190651; PMCID: PMC4193760.
  25. Black A, Vasireddy V, Chung DC, Maguire AM, Gaddameedi R, Tolmachova T, Seabra M, Bennett J. Adeno-associated virus 8-mediated gene therapy for choroideremia: preclinical studies in in vitro and in vivo models. J Gene Med. 2014 May-Jun; 16(5-6):122-30. PMID: 24962736.
    View in: PubMed
  26. Arnason T, Liang WY, Alfaro E, Kelly P, Chung DC, Odze RD, Lauwers GY. Morphology and natural history of familial adenomatous polyposis-associated dysplastic fundic gland polyps. Histopathology. 2014 Sep; 65(3):353-62. PMID: 24548295.
    View in: PubMed
  27. Richter JM, Pino MS, Austin TR, Campbell E, Szymonifka J, Russo AL, Hong TS, Borger D, Iafrate AJ, Chung DC. Genetic mechanisms in interval colon cancers. Dig Dis Sci. 2014 Sep; 59(9):2255-63. PMID: 24705641.
    View in: PubMed
  28. Ma T, Jang EJ, Zukerberg LR, Odze R, Gala MK, Kelsey PB, Forcione DG, Brugge WR, Casey BW, Syngal S, Chung DC. Recurrences are common after endoscopic ampullectomy for adenoma in the familial adenomatous polyposis (FAP) syndrome. Surg Endosc. 2014 Aug; 28(8):2349-56. PMID: 24566750; PMCID: PMC4217573.
  29. Gala MK, Mizukami Y, Le LP, Moriichi K, Austin T, Yamamoto M, Lauwers GY, Bardeesy N, Chung DC. Germline mutations in oncogene-induced senescence pathways are associated with multiple sessile serrated adenomas. Gastroenterology. 2014 Feb; 146(2):520-9. PMID: 24512911; PMCID: PMC3978775.
  30. Thilly WG, Gostjeva EV, Koledova VV, Zukerberg LR, Chung D, Fomina JN, Darroudi F, Stollar BD. Metakaryotic stem cell nuclei use pangenomic dsRNA/DNA intermediates in genome replication and segregation. Organogenesis. 2014 Jan 01; 10(1):44-52. PMID: 24418910; PMCID: PMC4049894.
  31. Wang L, Gala M, Yamamoto M, Pino MS, Kikuchi H, Shue DS, Shirasawa S, Austin TR, Lynch MP, Rueda BR, Zukerberg LR, Chung DC. Adrenomedullin is a therapeutic target in colorectal cancer. Int J Cancer. 2014 May 01; 134(9):2041-50. PMID: 24519534; PMCID: PMC3929229.
  32. Francis JM, Kiezun A, Ramos AH, Serra S, Pedamallu CS, Qian ZR, Banck MS, Kanwar R, Kulkarni AA, Karpathakis A, Manzo V, Contractor T, Philips J, Nickerson E, Pho N, Hooshmand SM, Brais LK, Lawrence MS, Pugh T, McKenna A, Sivachenko A, Cibulskis K, Carter SL, Ojesina AI, Freeman S, Jones RT, Voet D, Saksena G, Auclair D, Onofrio R, Shefler E, Sougnez C, Grimsby J, Green L, Lennon N, Meyer T, Caplin M, Chung DC, Beutler AS, Ogino S, Thirlwell C, Shivdasani R, Asa SL, Harris CR, Getz G, Kulke M, Meyerson M. Somatic mutation of CDKN1B in small intestine neuroendocrine tumors. Nat Genet. 2013 Dec; 45(12):1483-6. PMID: 24185511; PMCID: PMC4239432.
  33. Glynn M, Kirby D, Chung D, Kinahan DJ, Kijanka G, Ducrée J. Centrifugo-Magnetophoretic Purification of CD4+ Cells from Whole Blood Toward Future HIV/AIDS Point-of-Care Applications. J Lab Autom. 2014 Jun; 19(3):285-96. PMID: 24056858.
    View in: PubMed
  34. Canver MC, Canver AC, Revere KE, Amado D, Bennett J, Chung DC. Novel mathematical algorithm for pupillometric data analysis. Comput Methods Programs Biomed. 2014; 113(1):221-5. PMID: 24129048.
    View in: PubMed
  35. Kostic AD, Chun E, Robertson L, Glickman JN, Gallini CA, Michaud M, Clancy TE, Chung DC, Lochhead P, Hold GL, El-Omar EM, Brenner D, Fuchs CS, Meyerson M, Garrett WS. Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host Microbe. 2013 Aug 14; 14(2):207-15. PMID: 23954159; PMCID: PMC3772512.
  36. Shields HM, Stoffel EM, Chung DC, Sequist TD, Li JW, Pelletier SR, Spencer J, Silk JM, Austin BL, Diguette S, Furbish JE, Lederman R, Weingart SN. Disparities in evaluation of patients with rectal bleeding 40 years and older. Clin Gastroenterol Hepatol. 2014 Apr; 12(4):669-75; quiz e33. PMID: 23891918; PMCID: PMC4378237.
  37. Arnason T, Pino MS, Yilmaz O, Kirley SD, Rueda BR, Chung DC, Zukerberg LR. Cables1 is a tumor suppressor gene that regulates intestinal tumor progression in Apc(Min) mice. Cancer Biol Ther. 2013 Jul; 14(7):672-8. PMID: 23792637; PMCID: PMC3742496.
  38. Vasireddy V, Mills JA, Gaddameedi R, Basner-Tschakarjan E, Kohnke M, Black AD, Alexandrov K, Zhou S, Maguire AM, Chung DC, Mac H, Sullivan L, Gadue P, Bennicelli JL, French DL, Bennett J. AAV-mediated gene therapy for choroideremia: preclinical studies in personalized models. PLoS One. 2013; 8(5):e61396. PMID: 23667438; PMCID: PMC3646845.
  39. Oberg K, Casanovas O, Castaño JP, Chung D, Delle Fave G, Denèfle P, Harris P, Khan MS, Kulke MH, Scarpa A, Tang LH, Wiedenmann B. Molecular pathogenesis of neuroendocrine tumors: implications for current and future therapeutic approaches. Clin Cancer Res. 2013 Jun 01; 19(11):2842-9. PMID: 23459719.
    View in: PubMed
  40. Fujita H, Lennerz JK, Chung DC, Patel D, Deshpande V, Yoon SS, Lauwers GY. Endoscopic surveillance of patients with hereditary diffuse gastric cancer: biopsy recommendations after topographic distribution of cancer foci in a series of 10 CDH1-mutated gastrectomies. Am J Surg Pathol. 2012 Nov; 36(11):1709-17. PMID: 23073328.
    View in: PubMed
  41. Little MW, Chung D, Boardman P, Gleeson FV, Anderson EM. Microwave ablation of pulmonary malignancies using a novel high-energy antenna system. Cardiovasc Intervent Radiol. 2013 Apr; 36(2):460-5. PMID: 22968596.
    View in: PubMed
  42. Yurgelun MB, Mercado R, Rosenblatt M, Dandapani M, Kohlmann W, Conrad P, Blanco A, Shannon KM, Chung DC, Terdiman J, Gruber SB, Garber JE, Syngal S, Stoffel EM. Impact of genetic testing on endometrial cancer risk-reducing practices in women at risk for Lynch syndrome. Gynecol Oncol. 2012 Dec; 127(3):544-51. PMID: 22940489; PMCID: PMC3496001.
  43. Dhingra A, Ramakrishnan H, Neinstein A, Fina ME, Xu Y, Li J, Chung DC, Lyubarsky A, Vardi N. Gß3 is required for normal light ON responses and synaptic maintenance. J Neurosci. 2012 Aug 15; 32(33):11343-55. PMID: 22895717; PMCID: PMC3478105.
  44. Cronin T, Chung DC, Yang Y, Nandrot EF, Bennett J. The Signalling Role of the avß5-Integrin Can Impact the Efficacy of AAV in Retinal Gene Therapy. Pharmaceuticals (Basel). 2012 May 02; 5(5):447-59. PMID: 24281556; PMCID: PMC3763646.
  45. Shindler KS, Revere K, Dutt M, Ying GS, Chung DC. In vivo detection of experimental optic neuritis by pupillometry. Exp Eye Res. 2012 Jul; 100:1-6. PMID: 22561341; PMCID: PMC3923364.
  46. Duerr EM, Mizukami Y, Moriichi K, Gala M, Jo WS, Kikuchi H, Xavier RJ, Chung DC. Oncogenic KRAS regulates BMP4 expression in colon cancer cell lines. Am J Physiol Gastrointest Liver Physiol. 2012 May 15; 302(10):G1223-30. PMID: 22383492; PMCID: PMC3362092.
  47. Bennett J, Ashtari M, Wellman J, Marshall KA, Cyckowski LL, Chung DC, McCague S, Pierce EA, Chen Y, Bennicelli JL, Zhu X, Ying GS, Sun J, Wright JF, Auricchio A, Simonelli F, Shindler KS, Mingozzi F, High KA, Maguire AM. AAV2 gene therapy readministration in three adults with congenital blindness. Sci Transl Med. 2012 Feb 08; 4(120):120ra15. PMID: 22323828; PMCID: PMC4169122.
  48. Bennett J, Chung DC, Maguire A. Gene delivery to the retina: from mouse to man. Methods Enzymol. 2012; 507:255-74. PMID: 22365778; PMCID: PMC4061323.
  49. Chung DC, Fogelgren B, Park KM, Heidenberg J, Zuo X, Huang L, Bennett J, Lipschutz JH. Adeno-Associated Virus-Mediated Gene Transfer to Renal Tubule Cells via a Retrograde Ureteral Approach. Nephron Extra. 2011 Jan; 1(1):217-23. PMID: 22470395; PMCID: PMC3290852.
  50. Gala M, Chung DC. Hereditary colon cancer syndromes. Semin Oncol. 2011 Aug; 38(4):490-9. PMID: 21810508.
    View in: PubMed
  51. Pino MS, Chung DC. Microsatellite instability in the management of colorectal cancer. Expert Rev Gastroenterol Hepatol. 2011 Jun; 5(3):385-99. PMID: 21651356.
    View in: PubMed
  52. Ashtari M, Cyckowski LL, Monroe JF, Marshall KA, Chung DC, Auricchio A, Simonelli F, Leroy BP, Maguire AM, Shindler KS, Bennett J. The human visual cortex responds to gene therapy-mediated recovery of retinal function. J Clin Invest. 2011 Jun; 121(6):2160-8. PMID: 21606598; PMCID: PMC3104779.
  53. Blaszkowsky LS, Cusack JC, Hong TS, Chung DC, Blake MA, Lennerz JK. Case records of the Massachusetts General Hospital. Case 13-2011. A 49-year-old man with adenocarcinoma of the rectum. N Engl J Med. 2011 Apr 28; 364(17):1658-68. PMID: 21524217.
    View in: PubMed
  54. Mizukami Y, Kawamoto T, Sugiyama Y, Sasajima J, Koizumi K, Moriichi K, Fujiya M, Bardeesy N, Chung DC, Kohgo Y. Effect of transplantation of pro-angiogenic monocytes to pancreatic cancer-bearing mice on resistance to chemotherapy/radiotherapy. J Clin Oncol. 2011 Feb; 29(4_suppl):212. PMID: 27985919.
    View in: PubMed
  55. Chan AT, Baba Y, Shima K, Nosho K, Chung DC, Hung KE, Mahmood U, Madden K, Poss K, Ranieri A, Shue D, Kucherlapati R, Fuchs CS, Ogino S. Cathepsin B expression and survival in colon cancer: implications for molecular detection of neoplasia. Cancer Epidemiol Biomarkers Prev. 2010 Nov; 19(11):2777-85. PMID: 20833970; PMCID: PMC2976771.
  56. Chung DC. Molecular biology of neuroendocrine tumours. Regul Pept. 2010 Sep 9; 164(1):3-4. PMID: 26009325.
    View in: PubMed
  57. Pandalai PK, Lauwers GY, Chung DC, Patel D, Yoon SS. Prophylactic total gastrectomy for individuals with germline CDH1 mutation. Surgery. 2011 Mar; 149(3):347-55. PMID: 20719348.
    View in: PubMed
  58. Willett CG, Duda DG, Ancukiewicz M, Shah M, Czito BG, Bentley R, Poleski M, Fujita H, Lauwers GY, Carroll M, Tyler D, Mantyh C, Shellito P, Chung DC, Clark JW, Jain RK. A safety and survival analysis of neoadjuvant bevacizumab with standard chemoradiation in a phase I/II study compared with standard chemoradiation in locally advanced rectal cancer. Oncologist. 2010; 15(8):845-51. PMID: 20667969; PMCID: PMC3078712.
  59. Sasajima J, Mizukami Y, Sugiyama Y, Nakamura K, Kawamoto T, Koizumi K, Fujii R, Motomura W, Sato K, Suzuki Y, Tanno S, Fujiya M, Sasaki K, Shimizu N, Karasaki H, Kono T, Kawabe J, Ii M, Yoshiara H, Kamiyama N, Ashida T, Bardeesy N, Chung DC, Kohgo Y. Transplanting normal vascular proangiogenic cells to tumor-bearing mice triggers vascular remodeling and reduces hypoxia in tumors. Cancer Res. 2010 Aug 01; 70(15):6283-92. PMID: 20631070; PMCID: PMC3063898.
  60. Pino MS, Chung DC. Application of molecular diagnostics for the detection of Lynch syndrome. Expert Rev Mol Diagn. 2010 Jul; 10(5):651-65. PMID: 20629513; PMCID: PMC2929365.
  61. Fitzgerald RC, Hardwick R, Huntsman D, Carneiro F, Guilford P, Blair V, Chung DC, Norton J, Ragunath K, Van Krieken JH, Dwerryhouse S, Caldas C. Hereditary diffuse gastric cancer: updated consensus guidelines for clinical management and directions for future research. J Med Genet. 2010 Jul; 47(7):436-44. PMID: 20591882; PMCID: PMC2991043.
  62. Grafals M, Kamal L, Chung D, Abdi R. Gene polymorphisms in renal transplantation. Semin Nephrol. 2010 Jul; 30(4):418-25. PMID: 20807614.
    View in: PubMed
  63. Jang E, Chung DC. Hereditary colon cancer: lynch syndrome. Gut Liver. 2010 Jun; 4(2):151-60. PMID: 20559516; PMCID: PMC2886941.
  64. Zeng M, Kikuchi H, Pino MS, Chung DC. Hypoxia activates the K-ras proto-oncogene to stimulate angiogenesis and inhibit apoptosis in colon cancer cells. PLoS One. 2010 Jun 04; 5(6):e10966. PMID: 20532039; PMCID: PMC2881039.
  65. Pino MS, Chung DC. The chromosomal instability pathway in colon cancer. Gastroenterology. 2010 Jun; 138(6):2059-72. PMID: 20420946; PMCID: PMC4243705.
  66. Baba Y, Nosho K, Shima K, Irahara N, Chan AT, Meyerhardt JA, Chung DC, Giovannucci EL, Fuchs CS, Ogino S. HIF1A overexpression is associated with poor prognosis in a cohort of 731 colorectal cancers. Am J Pathol. 2010 May; 176(5):2292-301. PMID: 20363910; PMCID: PMC2861094.
  67. Stoffel EM, Mercado RC, Kohlmann W, Ford B, Grover S, Conrad P, Blanco A, Shannon KM, Powell M, Chung DC, Terdiman J, Gruber SB, Syngal S. Prevalence and predictors of appropriate colorectal cancer surveillance in Lynch syndrome. Am J Gastroenterol. 2010 Aug; 105(8):1851-60. PMID: 20354509; PMCID: PMC3091484.
  68. Hirota SA, Fines K, Ng J, Traboulsi D, Lee J, Ihara E, Li Y, Willmore WG, Chung D, Scully MM, Louie T, Medlicott S, Lejeune M, Chadee K, Armstrong G, Colgan SP, Muruve DA, MacDonald JA, Beck PL. Hypoxia-inducible factor signaling provides protection in Clostridium difficile-induced intestinal injury. Gastroenterology. 2010 Jul; 139(1):259-69.e3. PMID: 20347817; PMCID: PMC3063899.
  69. Manne SL, Meropol NJ, Weinberg DS, Vig H, Ali-Khan Catts Z, Manning C, Ross E, Shannon K, Chung DC. Facilitating informed decisions regarding microsatellite instability testing among high-risk individuals diagnosed with colorectal cancer. J Clin Oncol. 2010 Mar 10; 28(8):1366-72. PMID: 20142594; PMCID: PMC2834496.
  70. Nakamura K, Sasajima J, Mizukami Y, Sugiyama Y, Yamazaki M, Fujii R, Kawamoto T, Koizumi K, Sato K, Fujiya M, Sasaki K, Tanno S, Okumura T, Shimizu N, Kawabe J, Karasaki H, Kono T, Ii M, Bardeesy N, Chung DC, Kohgo Y. Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells. PLoS One. 2010 Jan 21; 5(1):e8824. PMID: 20098680; PMCID: PMC2809097.
  71. Park KM, Fogelgren B, Zuo X, Kim J, Chung DC, Lipschutz JH. Exocyst Sec10 protects epithelial barrier integrity and enhances recovery following oxidative stress, by activation of the MAPK pathway. Am J Physiol Renal Physiol. 2010 Mar; 298(3):F818-26. PMID: 20053792; PMCID: PMC2838587.
  72. Pino MS, Kikuchi H, Zeng M, Herraiz MT, Sperduti I, Berger D, Park DY, Iafrate AJ, Zukerberg LR, Chung DC. Epithelial to mesenchymal transition is impaired in colon cancer cells with microsatellite instability. Gastroenterology. 2010 Apr; 138(4):1406-17. PMID: 20026115; PMCID: PMC2846966.
  73. Chung DC, Traboulsi EI. Leber congenital amaurosis: clinical correlations with genotypes, gene therapy trials update, and future directions. J AAPOS. 2009 Dec; 13(6):587-92. PMID: 20006823.
    View in: PubMed
  74. Maguire AM, High KA, Auricchio A, Wright JF, Pierce EA, Testa F, Mingozzi F, Bennicelli JL, Ying GS, Rossi S, Fulton A, Marshall KA, Banfi S, Chung DC, Morgan JI, Hauck B, Zelenaia O, Zhu X, Raffini L, Coppieters F, De Baere E, Shindler KS, Volpe NJ, Surace EM, Acerra C, Lyubarsky A, Redmond TM, Stone E, Sun J, McDonnell JW, Leroy BP, Simonelli F, Bennett J. Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial. Lancet. 2009 Nov 07; 374(9701):1597-605. PMID: 19854499; PMCID: PMC4492302.
  75. Kikuchi H, Pino MS, Zeng M, Shirasawa S, Chung DC. Oncogenic KRAS and BRAF differentially regulate hypoxia-inducible factor-1alpha and -2alpha in colon cancer. Cancer Res. 2009 Nov 01; 69(21):8499-506. PMID: 19843849; PMCID: PMC2811371.
  76. Xu L, Duda DG, di Tomaso E, Ancukiewicz M, Chung DC, Lauwers GY, Samuel R, Shellito P, Czito BG, Lin PC, Poleski M, Bentley R, Clark JW, Willett CG, Jain RK. Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer. Cancer Res. 2009 Oct 15; 69(20):7905-10. PMID: 19826039; PMCID: PMC2859041.
  77. Revere KE, Chung DC. Recent breakthroughs in gene therapy for inherited retinal degeneration. Discov Med. 2009 Oct; 8(42):125-9. PMID: 19833058.
    View in: PubMed
  78. Greenblatt WH, Hur C, Knudsen AB, Evans JA, Chung DC, Gazelle GS. Cost-effectiveness of prophylactic surgery for duodenal cancer in familial adenomatous polyposis. Cancer Epidemiol Biomarkers Prev. 2009 Oct; 18(10):2677-84. PMID: 19789369; PMCID: PMC2759853.
  79. Chung DC, Lee V, Maguire AM. Recent advances in ocular gene therapy. Curr Opin Ophthalmol. 2009 Sep; 20(5):377-81. PMID: 19667988.
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  80. Grover S, Stoffel EM, Mercado RC, Ford BM, Kohlman WK, Shannon KM, Conrad PG, Blanco AM, Terdiman JP, Gruber SB, Chung DC, Syngal S. Colorectal cancer risk perception on the basis of genetic test results in individuals at risk for Lynch syndrome. J Clin Oncol. 2009 Aug 20; 27(24):3981-6. PMID: 19620492; PMCID: PMC2734398.
  81. Benita Y, Kikuchi H, Smith AD, Zhang MQ, Chung DC, Xavier RJ. An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia. Nucleic Acids Res. 2009 Aug; 37(14):4587-602. PMID: 19491311; PMCID: PMC2724271.
  82. Willett CG, Duda DG, di Tomaso E, Boucher Y, Ancukiewicz M, Sahani DV, Lahdenranta J, Chung DC, Fischman AJ, Lauwers GY, Shellito P, Czito BG, Wong TZ, Paulson E, Poleski M, Vujaskovic Z, Bentley R, Chen HX, Clark JW, Jain RK. Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study. J Clin Oncol. 2009 Jun 20; 27(18):3020-6. PMID: 19470921; PMCID: PMC2702234.
  83. Bertagnolli MM, Eagle CJ, Zauber AG, Redston M, Breazna A, Kim K, Tang J, Rosenstein RB, Umar A, Bagheri D, Collins NT, Burn J, Chung DC, Dewar T, Foley TR, Hoffman N, Macrae F, Pruitt RE, Saltzman JR, Salzberg B, Sylwestrowicz T, Hawk ET. Five-year efficacy and safety analysis of the Adenoma Prevention with Celecoxib Trial. Cancer Prev Res (Phila). 2009 Apr; 2(4):310-21. PMID: 19336730; PMCID: PMC2976587.
  84. Pino MS, Mino-Kenudson M, Wildemore BM, Ganguly A, Batten J, Sperduti I, Iafrate AJ, Chung DC. Deficient DNA mismatch repair is common in Lynch syndrome-associated colorectal adenomas. J Mol Diagn. 2009 May; 11(3):238-47. PMID: 19324997; PMCID: PMC2671341.
  85. Imamura T, Kikuchi H, Herraiz MT, Park DY, Mizukami Y, Mino-Kenduson M, Lynch MP, Rueda BR, Benita Y, Xavier RJ, Chung DC. HIF-1alpha and HIF-2alpha have divergent roles in colon cancer. Int J Cancer. 2009 Feb 15; 124(4):763-71. PMID: 19030186; PMCID: PMC2682346.
  86. Chung DC. Stool DNA testing and colon cancer prevention: another step forward. Ann Intern Med. 2008 Oct 07; 149(7):509-10. PMID: 18838731.
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  87. Modlin IM, Moss SF, Chung DC, Jensen RT, Snyderwine E. Priorities for improving the management of gastroenteropancreatic neuroendocrine tumors. J Natl Cancer Inst. 2008 Sep 17; 100(18):1282-9. PMID: 18780869; PMCID: PMC2538549.
  88. Fujiki K, Duerr EM, Kikuchi H, Ng A, Xavier RJ, Mizukami Y, Imamura T, Kulke MH, Chung DC. Hoxc6 is overexpressed in gastrointestinal carcinoids and interacts with JunD to regulate tumor growth. Gastroenterology. 2008 Sep; 135(3):907-16, 916.e1-2. PMID: 18655788; PMCID: PMC3777410.
  89. Hernandez JC, Reicher S, Chung D, Pham BV, Tsai F, Disibio G, French S, Eysselein VE. Pilot series of radiofrequency ablation of Barrett's esophagus with or without neoplasia. Endoscopy. 2008 May; 40(5):388-92. PMID: 18459075.
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  90. Yamazaki M, Nakamura K, Mizukami Y, Ii M, Sasajima J, Sugiyama Y, Nishikawa T, Nakano Y, Yanagawa N, Sato K, Maemoto A, Tanno S, Okumura T, Karasaki H, Kono T, Fujiya M, Ashida T, Chung DC, Kohgo Y. Sonic hedgehog derived from human pancreatic cancer cells augments angiogenic function of endothelial progenitor cells. Cancer Sci. 2008 Jun; 99(6):1131-8. PMID: 18422746.
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  91. Duerr EM, Mizukami Y, Ng A, Xavier RJ, Kikuchi H, Deshpande V, Warshaw AL, Glickman J, Kulke MH, Chung DC. Defining molecular classifications and targets in gastroenteropancreatic neuroendocrine tumors through DNA microarray analysis. Endocr Relat Cancer. 2008 Mar; 15(1):243-56. PMID: 18310291.
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  92. Stoffel EM, Ford B, Mercado RC, Punglia D, Kohlmann W, Conrad P, Blanco A, Shannon KM, Powell M, Gruber SB, Terdiman J, Chung DC, Syngal S. Sharing genetic test results in Lynch syndrome: communication with close and distant relatives. Clin Gastroenterol Hepatol. 2008 Mar; 6(3):333-8. PMID: 18258490; PMCID: PMC2536607.
  93. Bennicelli J, Wright JF, Komaromy A, Jacobs JB, Hauck B, Zelenaia O, Mingozzi F, Hui D, Chung D, Rex TS, Wei Z, Qu G, Zhou S, Zeiss C, Arruda VR, Acland GM, Dell'Osso LF, High KA, Maguire AM, Bennett J. Reversal of blindness in animal models of leber congenital amaurosis using optimized AAV2-mediated gene transfer. Mol Ther. 2008 Mar; 16(3):458-65. PMID: 18209734; PMCID: PMC2842085.
  94. Modlin IM, Oberg K, Chung DC, Jensen RT, de Herder WW, Thakker RV, Caplin M, Delle Fave G, Kaltsas GA, Krenning EP, Moss SF, Nilsson O, Rindi G, Salazar R, Ruszniewski P, Sundin A. Gastroenteropancreatic neuroendocrine tumours. Lancet Oncol. 2008 Jan; 9(1):61-72. PMID: 18177818.
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  95. Sakamoto H, Friel AM, Wood AW, Guo L, Ilic A, Seiden MV, Chung DC, Lynch MP, Serikawa T, Munro E, Oliva E, Orsulic S, Kirley SD, Foster R, Zukerberg LR, Rueda BR. Mechanisms of Cables 1 gene inactivation in human ovarian cancer development. Cancer Biol Ther. 2008 Feb; 7(2):180-88. PMID: 18059193.
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  96. Park DY, Sakamoto H, Kirley SD, Ogino S, Kawasaki T, Kwon E, Mino-Kenudson M, Lauwers GY, Chung DC, Rueda BR, Zukerberg LR. The Cables gene on chromosome 18q is silenced by promoter hypermethylation and allelic loss in human colorectal cancer. Am J Pathol. 2007 Nov; 171(5):1509-19. PMID: 17982127; PMCID: PMC2043512.
  97. Manne SL, Chung DC, Weinberg DS, Vig HS, Catts Z, Cabral MK, Shannon K, Meropol NJ. Knowledge and attitudes about microsatellite instability testing among high-risk individuals diagnosed with colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2007 Oct; 16(10):2110-7. PMID: 17932359.
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  98. Mizukami Y, Kohgo Y, Chung DC. Hypoxia inducible factor-1 independent pathways in tumor angiogenesis. Clin Cancer Res. 2007 Oct 01; 13(19):5670-4. PMID: 17908955.
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  99. Chung D, Ghossein RA, Lin O. Macrofollicular variant of papillary carcinoma: a potential thyroid FNA pitfall. Diagn Cytopathol. 2007 Sep; 35(9):560-4. PMID: 17703452.
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  100. Choi MY, Lauwers GY, Hur C, Willett CG, Chung DC. Microsatellite instability is frequently observed in rectal cancer and influenced by neoadjuvant chemoradiation. Int J Radiat Oncol Biol Phys. 2007 Aug 01; 68(5):1584. PMID: 17674996.
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  101. Chung DC, Yoon SS, Lauwers GY, Patel D. Case records of the Massachusetts General Hospital. Case 22-2007. A woman with a family history of gastric and breast cancer. N Engl J Med. 2007 Jul 19; 357(3):283-91. PMID: 17634464.
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  102. Kaurah P, MacMillan A, Boyd N, Senz J, De Luca A, Chun N, Suriano G, Zaor S, Van Manen L, Gilpin C, Nikkel S, Connolly-Wilson M, Weissman S, Rubinstein WS, Sebold C, Greenstein R, Stroop J, Yim D, Panzini B, McKinnon W, Greenblatt M, Wirtzfeld D, Fontaine D, Coit D, Yoon S, Chung D, Lauwers G, Pizzuti A, Vaccaro C, Redal MA, Oliveira C, Tischkowitz M, Olschwang S, Gallinger S, Lynch H, Green J, Ford J, Pharoah P, Fernandez B, Huntsman D. Founder and recurrent CDH1 mutations in families with hereditary diffuse gastric cancer. JAMA. 2007 Jun 06; 297(21):2360-72. PMID: 17545690.
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  103. Duerr EM, Chung DC. Molecular genetics of neuroendocrine tumors. Best Pract Res Clin Endocrinol Metab. 2007 Mar; 21(1):1-14. PMID: 17382262.
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  104. Ruszniewski P, Delle Fave G, Cadiot G, Komminoth P, Chung D, Kos-Kudla B, Kianmanesh R, Hochhauser D, Arnold R, Ahlman H, Pauwels S, Kwekkeboom DJ, Rindi G. Well-differentiated gastric tumors/carcinomas. Neuroendocrinology. 2006; 84(3):158-64. PMID: 17312375.
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  105. Hur C, Chung DC, Schoen RE, Gazelle GS. The management of small polyps found by virtual colonoscopy: results of a decision analysis. Clin Gastroenterol Hepatol. 2007 Feb; 5(2):237-44. PMID: 17296532.
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  106. Herraiz M, Barbesino G, Faquin W, Chan-Smutko G, Patel D, Shannon KM, Daniels GH, Chung DC. Prevalence of thyroid cancer in familial adenomatous polyposis syndrome and the role of screening ultrasound examinations. Clin Gastroenterol Hepatol. 2007 Mar; 5(3):367-73. PMID: 17258512.
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  107. Endo M, Zoltick PW, Chung DC, Bennett J, Radu A, Muvarak N, Flake AW. Gene transfer to ocular stem cells by early gestational intraamniotic injection of lentiviral vector. Mol Ther. 2007 Mar; 15(3):579-87. PMID: 17245352.
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  108. Kwak EL, Chung DC. Hereditary colorectal cancer syndromes: an overview. Clin Colorectal Cancer. 2007 Jan; 6(5):340-4. PMID: 17311698.
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  109. O'Keefe SJ, Chung D, Mahmoud N, Sepulveda AR, Manafe M, Arch J, Adada H, van der Merwe T. Why do African Americans get more colon cancer than Native Africans? J Nutr. 2007 Jan; 137(1 Suppl):175S-182S. PMID: 17182822.
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  110. Chung DC, Maher MM, Faquin WC. Case records of the Massachusetts General Hospital. Case 37-2006. A 19-year-old woman with thyroid cancer and lower gastrointestinal bleeding. N Engl J Med. 2006 Nov 30; 355(22):2349-57. PMID: 17135589.
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  111. Lauwers GY, Chung DC. The serrated polyp comes of age. Gastroenterology. 2006 Nov; 131(5):1631-4. PMID: 17067594.
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  112. Bertagnolli MM, Eagle CJ, Zauber AG, Redston M, Solomon SD, Kim K, Tang J, Rosenstein RB, Wittes J, Corle D, Hess TM, Woloj GM, Boisserie F, Anderson WF, Viner JL, Bagheri D, Burn J, Chung DC, Dewar T, Foley TR, Hoffman N, Macrae F, Pruitt RE, Saltzman JR, Salzberg B, Sylwestrowicz T, Gordon GB, Hawk ET. Celecoxib for the prevention of sporadic colorectal adenomas. N Engl J Med. 2006 Aug 31; 355(9):873-84. PMID: 16943400.
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  113. Melamud A, Shen GQ, Chung D, Xi Q, Simpson E, Li L, Peachey NS, Zegarra H, Hagstrom SA, Wang QK, Traboulsi EI. Mapping a new genetic locus for X linked retinitis pigmentosa to Xq28. J Med Genet. 2006 Jun; 43(6):e27. PMID: 16740911; PMCID: PMC2593026.
  114. Bidinost C, Matsumoto M, Chung D, Salem N, Zhang K, Stockton DW, Khoury A, Megarbane A, Bejjani BA, Traboulsi EI. Heterozygous and homozygous mutations in PITX3 in a large Lebanese family with posterior polar cataracts and neurodevelopmental abnormalities. Invest Ophthalmol Vis Sci. 2006 Apr; 47(4):1274-80. PMID: 16565358.
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  115. Mizukami Y, Fujiki K, Duerr EM, Gala M, Jo WS, Zhang X, Chung DC. Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-kinase/Rho/ROCK and c-Myc. J Biol Chem. 2006 May 19; 281(20):13957-63. PMID: 16543245.
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  116. Hung KE, Chung DC. Colorectal cancer screening: today and tomorrow. South Med J. 2006 Mar; 99(3):240-6; quiz 247-9. PMID: 16553098.
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  117. Syngal S, Stoffel E, Chung D, Willett C, Schoetz D, Schroy P, Jagadeesh D, Morel K, Ross M. Detection of stool DNA mutations before and after treatment of colorectal neoplasia. Cancer. 2006 Jan 15; 106(2):277-83. PMID: 16342248.
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  118. Gostjeva EV, Zukerberg L, Chung D, Thilly WG. Bell-shaped nuclei dividing by symmetrical and asymmetrical nuclear fission have qualities of stem cells in human colonic embryogenesis and carcinogenesis. Cancer Genet Cytogenet. 2006 Jan 01; 164(1):16-24. PMID: 16364758.
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  119. Hung KE, Chung DC. New insights into the molecular pathogenesis of colorectal cancer. Drug Discov Today Dis Mech. 2006; 3(4):439. PMID: 20151020.
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  120. Jo WS, Mizukami Y, Duerr EM, Zukerberg LR, Chung DC. Wnt signaling can repress thrombospondin-1 expression in colonic tumorigenesis. Cancer Biol Ther. 2005 Dec; 4(12):1361-6. PMID: 16258261.
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  121. Willett CG, Boucher Y, Duda DG, di Tomaso E, Munn LL, Tong RT, Kozin SV, Petit L, Jain RK, Chung DC, Sahani DV, Kalva SP, Cohen KS, Scadden DT, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Shellito PC, Mino-Kenudson M, Lauwers GY. Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients. J Clin Oncol. 2005 Nov 01; 23(31):8136-9. PMID: 16258121.
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  122. Korzenik J, Chung DC, Digumarthy S, Badizadegan K. Case records of the Massachusetts General Hospital. Case 33-2005. A 43-year-old man with lower gastrointestinal bleeding. N Engl J Med. 2005 Oct 27; 353(17):1836-44. PMID: 16251540.
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  123. Jo WS, Bandipalliam P, Shannon KM, Niendorf KB, Chan-Smutko G, Hur C, Syngal S, Chung DC. Correlation of polyp number and family history of colon cancer with germline MYH mutations. Clin Gastroenterol Hepatol. 2005 Oct; 3(10):1022-8. PMID: 16234049.
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  125. Kirley SD, D'Apuzzo M, Lauwers GY, Graeme-Cook F, Chung DC, Zukerberg LR. The Cables gene on chromosome 18Q regulates colon cancer progression in vivo. Cancer Biol Ther. 2005 Aug; 4(8):861-3. PMID: 16210915.
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  126. Kirley SD, Rueda BR, Chung DC, Zukerberg LR. Increased growth rate, delayed senescense and decreased serum dependence characterize cables-deficient cells. Cancer Biol Ther. 2005 Jun; 4(6):654-8. PMID: 15908791.
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  127. Li J, Mizukami Y, Zhang X, Jo WS, Chung DC. Oncogenic K-ras stimulates Wnt signaling in colon cancer through inhibition of GSK-3beta. Gastroenterology. 2005 Jun; 128(7):1907-18. PMID: 15940626.
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  128. Costa-Guda J, Rosen ED, Jensen RT, Chung DC, Arnold A. Mutational analysis of PPARG as a candidate tumour suppressor gene in enteropancreatic endocrine tumours. Clin Endocrinol (Oxf). 2005 May; 62(5):603-6. PMID: 15853832.
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  129. Velayos FS, Allen BA, Conrad PG, Gum J, Kakar S, Chung DC, Truta B, Sleisenger MH, Kim YS, Terdiman JP. Low rate of microsatellite instability in young patients with adenomas: reassessing the Bethesda guidelines. Am J Gastroenterol. 2005 May; 100(5):1143-9. PMID: 15842591.
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  130. Zhang X, Gaspard JP, Mizukami Y, Li J, Graeme-Cook F, Chung DC. Overexpression of cyclin D1 in pancreatic beta-cells in vivo results in islet hyperplasia without hypoglycemia. Diabetes. 2005 Mar; 54(3):712-9. PMID: 15734847.
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  131. Jo WS, Chung DC. Genetics of hereditary colorectal cancer. Semin Oncol. 2005 Feb; 32(1):11-23. PMID: 15726502.
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  132. Traboulsi EI, Chung D, Koors JM. Polychromasia capsulare (multicolored capsule): report of three families. Trans Am Ophthalmol Soc. 2005; 103:93-7; discussion 97. PMID: 17057792; PMCID: PMC1447563.
  133. Wong WT, Rex TS, Auricchio A, Maguire AM, Chung D, Tang W, Bennett J. Effect of over-expression of pigment epithelium derived factor (PEDF) on developing retinal vasculature in the mouse. Mol Vis. 2004 Nov 08; 10:837-44. PMID: 15547489.
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  134. Chung DC. Cyclin D1 in human neuroendocrine: tumorigenesis. Ann N Y Acad Sci. 2004 Apr; 1014:209-17. PMID: 15153436.
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  135. Mizukami Y, Li J, Zhang X, Zimmer MA, Iliopoulos O, Chung DC. Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer. Cancer Res. 2004 Mar 01; 64(5):1765-72. PMID: 14996738.
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  136. Willett CG, Boucher Y, di Tomaso E, Duda DG, Munn LL, Tong RT, Chung DC, Sahani DV, Kalva SP, Kozin SV, Mino M, Cohen KS, Scadden DT, Hartford AC, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Chen HX, Shellito PC, Lauwers GY, Jain RK. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med. 2004 Feb; 10(2):145-7. PMID: 14745444; PMCID: PMC2693485.
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  138. Yazdani A, Chung DC, Abbaszadegan MR, Al-Khayer K, Chan WM, Yazdani M, Ghodsi K, Engle EC, Traboulsi EI. A novel PHOX2A/ARIX mutation in an Iranian family with congenital fibrosis of extraocular muscles type 2 (CFEOM2). Am J Ophthalmol. 2003 Nov; 136(5):861-5. PMID: 14597037.
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  139. Chung DC, Mino M, Shannon KM. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 34-2003. A 45-year-old woman with a family history of colonic polyps and cancer. N Engl J Med. 2003 Oct 30; 349(18):1750-60. PMID: 14585944.
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  140. Hwang JM, Chung DC, Traboulsi EI. A new syndrome of hereditary congenital corneal opacities, cornea guttata, and corectopia. Arch Ophthalmol. 2003 Jul; 121(7):1053-4. PMID: 12860817.
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  141. Chung DC, Rustgi AK. The hereditary nonpolyposis colorectal cancer syndrome: genetics and clinical implications. Ann Intern Med. 2003 Apr 01; 138(7):560-70. PMID: 12667026.
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  142. Marmorstein LY, Munier FL, Arsenijevic Y, Schorderet DF, McLaughlin PJ, Chung D, Traboulsi E, Marmorstein AD. Aberrant accumulation of EFEMP1 underlies drusen formation in Malattia Leventinese and age-related macular degeneration. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):13067-72. PMID: 12242346; PMCID: PMC130587.
  143. Shattuck TM, Costa J, Bernstein M, Jensen RT, Chung DC, Arnold A. Mutational analysis of Smad3, a candidate tumor suppressor implicated in TGF-beta and menin pathways, in parathyroid adenomas and enteropancreatic endocrine tumors. J Clin Endocrinol Metab. 2002 Aug; 87(8):3911-4. PMID: 12161532.
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  144. Yoo LI, Chung DC, Yuan J. LKB1--a master tumour suppressor of the small intestine and beyond. Nat Rev Cancer. 2002 Jul; 2(7):529-35. PMID: 12094239.
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  145. Wu CL, Kirley SD, Xiao H, Chuang Y, Chung DC, Zukerberg LR. Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers. Cancer Res. 2001 Oct 01; 61(19):7325-32. PMID: 11585773.
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  146. Zhang X, Gaspard JP, Chung DC. Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia. Cancer Res. 2001 Aug 15; 61(16):6050-4. PMID: 11507052.
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  147. Chung DC, Brown SB, Graeme-Cook F, Seto M, Warshaw AL, Jensen RT, Arnold A. Overexpression of cyclin D1 occurs frequently in human pancreatic endocrine tumors. J Clin Endocrinol Metab. 2000 Nov; 85(11):4373-8. PMID: 11095482.
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  148. Chung DC. The genetic basis of colorectal cancer: insights into critical pathways of tumorigenesis. Gastroenterology. 2000 Sep; 119(3):854-65. PMID: 10982779.
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  149. Syngal S, Schrag D, Falchuk M, Tung N, Farraye FA, Chung D, Wright M, Whetsell A, Miller G, Garber JE. Phenotypic characteristics associated with the APC gene I1307K mutation in Ashkenazi Jewish patients with colorectal polyps. JAMA. 2000 Aug 16; 284(7):857-60. PMID: 10938175.
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  150. Nakata H, Wang SL, Chung DC, Westwick JK, Tillotson LG. Oncogenic ras induces gastrin gene expression in colon cancer. Gastroenterology. 1998 Nov; 115(5):1144-53. PMID: 9797369.
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  151. Perez VM, Huang GJ, Musselman PW, Chung D. Lower gastrointestinal bleeding as the initial presenting symptom of renal cell carcinoma. Am J Gastroenterol. 1998 Nov; 93(11):2293-4. PMID: 9820422.
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  152. Chung DC, Brown SB, Graeme-Cook F, Tillotson LG, Warshaw AL, Jensen RT, Arnold A. Localization of putative tumor suppressor loci by genome-wide allelotyping in human pancreatic endocrine tumors. Cancer Res. 1998 Aug 15; 58(16):3706-11. PMID: 9721882.
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  153. Chung DC. Molecular prognostic markers and colorectal cancer: the search goes on. Gastroenterology. 1998 Jun; 114(6):1330-2. PMID: 9618651.
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  154. Chung DC, Smith AP, Louis DN, Graeme-Cook F, Warshaw AL, Arnold A. Analysis of the retinoblastoma tumour suppressor gene in pancreatic endocrine tumours. Clin Endocrinol (Oxf). 1997 Nov; 47(5):523-8. PMID: 9425391.
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  155. Chung DC, Smith AP, Louis DN, Graeme-Cook F, Warshaw AL, Arnold A. A novel pancreatic endocrine tumor suppressor gene locus on chromosome 3p with clinical prognostic implications. J Clin Invest. 1997 Jul 15; 100(2):404-10. PMID: 9218518; PMCID: PMC508204.
  156. Chung DC, Niranjan SC, Clark JW, Bidani A, Johnston WE, Zwischenberger JB, Traber DL. A dynamic model of ventricular interaction and pericardial influence. Am J Physiol. 1997 Jun; 272(6 Pt 2):H2942-62. PMID: 9227574.
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  157. Chung DC, Stasior DS, Friedman LS. Acute Pancreatitis. Quick-consult manual of evidence-based medicine (Lee BW, Hsu SI, Stasior DS). 1997; 295-310.
  158. Sullivan DM, Chung DC, Anglade E, Nussenblatt RB, Csaky KG. Adenovirus-mediated gene transfer of ornithine aminotransferase in cultured human retinal pigment epithelium. Invest Ophthalmol Vis Sci. 1996 Apr; 37(5):766-74. PMID: 8603861.
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  159. Chung DC, Rustgi AK. DNA mismatch repair and cancer. Gastroenterology. 1995 Nov; 109(5):1685-99. PMID: 7557155.
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  160. Chung DC, Brand SJ, Tillotson LG. Mutually exclusive interactions between factors binding to adjacent Sp1 and AT-rich elements regulate gastrin gene transcription in insulinoma cells. J Biol Chem. 1995 Apr 14; 270(15):8829-36. PMID: 7721790.
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  161. Chui PT, Mainland P, Chung SC, Chung DC. Anaesthesia for three-stage thoracoscopic oesophagectomy: an initial experience. Anaesth Intensive Care. 1994 Oct; 22(5):593-6. PMID: 7818066.
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  162. Yang X, Chung D, Cepko CL. Molecular cloning of the murine JAK1 protein tyrosine kinase and its expression in the mouse central nervous system. J Neurosci. 1993 Jul; 13(7):3006-17. PMID: 8331382.
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  163. Mendrick DL, Chung DC, Rennke HG. Heymann antigen GP330 demonstrates affinity for fibronectin, laminin, and type I collagen and mediates rat proximal tubule epithelial cell adherence to such matrices in vitro. Exp Cell Res. 1990 May; 188(1):23-35. PMID: 1691715.
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  164. Chung DC, Ko YC, Pai HH. [A study on the prevalence and risk factors of muscular fibrotic contracture in Jia-Dong Township, Pingtung County, Taiwan]. Gaoxiong Yi Xue Ke Xue Za Zhi. 1989 Feb; 5(2):91-5. PMID: 2786573.
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  165. Chung DC, Ko YC, Chen CJ, Wu CC, Chen ER, Liaw YF, Hwang SJ. Seroepidemiological studies on hepatitis B and D viruses infection among five ethnic groups in southern Taiwan. J Med Virol. 1988 Dec; 26(4):411-8. PMID: 3209993.
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  166. Millman RP, Knight H, Kline LR, Shore ET, Chung DC, Pack AI. Changes in compartmental ventilation in association with eye movements during REM sleep. J Appl Physiol (1985). 1988 Sep; 65(3):1196-202. PMID: 3182489.
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  167. Pack AI, Silage DA, Millman RP, Knight H, Shore ET, Chung DC. Spectral analysis of ventilation in elderly subjects awake and asleep. J Appl Physiol (1985). 1988 Mar; 64(3):1257-67. PMID: 3366740.
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  168. Kerr CR, Cooper J, Chung DC, Lai-Wah JA. Termination of sustained ventricular tachycardia by transesophageal atrial pacing. Am J Cardiol. 1988 Feb 15; 61(6):463-4. PMID: 3341230.
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  169. Chung DC, Zetter BR, Brodt P. Lewis lung carcinoma variants with differing metastatic specificities adhere preferentially to different defined extracellular matrix molecules. Invasion Metastasis. 1988; 8(2):103-17. PMID: 3360591.
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